Background: Most people believe that student–athletes experience fewer difficulties related to mental health than non-sport participants. However, several studies have shown high depression levels or emotional difficulties in adolescent athletes. Most secondary school students have access to athletic trainers in their schools. Secondary school athletic trainers (SSATs) are medical professionals who can provide health care for student–athletes, and they could be appropriate supporters in providing mental health management in secondary schools. However, there are no studies that have addressed their preparedness and confidence level to manage potential risk factors and mental health disorders. This study aims to ascertain preparedness and confidence levels from SSATs’ perspectives in handling mental health disorders using a survey based on the mental health management guidelines and consensus statement. Methods: This is a cross-sectional study design. The research team created an online survey questionnaire based on the National Athletic Trainers’ Association (NATA) Mental Health Guidelines for Secondary School and Interassociation Recommendation: A Consensus Statement. Utilizing the NATA Research Survey Service, the online survey was emailed to SSATs who self-categorized as secondary school athletic trainers in the NATA membership system. (n = 171, 65% completion rate). SPSS was used to analyze the survey data. Result: This study found that 29.2% of SSATs reported they have policies or guidelines regarding mental health disorders management for minors. The most frequent policy was mandatory reporting in cases in which an individual is being abused or neglected (80.5%). The highest confidence area was aligned with the most frequent policy. The least frequent policy was considering unique stressors and triggers with student–athletes to recognize the potential mechanisms that may cause a mental illness or exacerbate an existing mental illness (58.5%). Even though the least frequent policy was not aligned with the least confidence area, it was the second lowest confidence level. This study identified significant differences between two different employment structures: school-based employment and hospital-based employment structures. Policies were more common in school-based employment than in hospital-based employment structures. Conclusion: This study demonstrated the gap between organizational and individual preparation. The majority of SSATs respondents expressed moderate to high confidence in their ability to manage mental health disorders, despite the lack of mental health policies or procedures in their secondary schools. This study recommends that SSATs create guidelines or procedures in the areas where they are least confident and prepared to offer mental health management for minor student–athletes. They can use the interassociation recommendations and the NATA guidelines for mental health care to close the gap. Full article

Thinning is a silvicultural process in which trees are both harvested selectively and systematically removed from a stand to enhance forest management and ecosystem dynamics. However, this practice is challenged by the mechanical damage to residual trees, and the nature of this damage, particularly on stand damage during mechanized row-thinning and manual selective thinning, in South Korea is unknown. Therefore, objectives of this study were to compare stand damage levels and wound characteristics between three different thinning operations: manual selective, manual row-, and mechanized row-thinning. After thinning, 12%, 15%, and 10% of the residual damaged trees were observed in manual selective, manual row-, and mechanized row-thinning, respectively. Both types of row-thinning predominantly demonstrated damages at the stem and butt region, whereas in manual selective thinning, the most of the damages occurred on the roots. Manual selective thinning exhibited a slightly larger average wound size (207 cm²) compared to mechanized row- (181 cm²) and manual row-thinning (165 cm²). The wound sizes on the stem in mechanized row-thinning were significantly higher than manual selective (p < 0.05). These results may be helpful in understanding exposure to damage among different thinning types and in managing its occurrence in future practices. Full article

The mechanical characteristics and sliding friction behaviors of AA7075 samples were studied in regard to structural states formed in them by ECAP and depending on the ECAP pass number. In addition, the effect of a counterbody’s material on the tribological characteristics of the samples was investigated by the examples of AISI 52100 steel, alumina Al₂O₃ and silicon nitride Si₃N₄. Vibration acceleration and acoustic emission signals with parameters such as acoustic emission energy and median frequency were used for characterizing the sliding regimes. The structural state and mechanical properties of the ECAPed AA7075 samples significantly affected their wear behaviors in dry sliding. The counterbody material had a significant influence on the formation of a transfer layer and the subsurface deformation of samples. The dynamic behavior of the tribosystem was studied and the relationship between the sliding parameters, vibrometry and acoustic emission signals was established. Full article

Lymphoproliferative diseases are a heterogeneous set of malignant clonal proliferations of lymphocytes. Despite well-established diagnostic criteria, the diagnosis remains difficult due to their variety in clinical presentation and immunophenotypic profile. Lymphoid T-cell disorders are less common than B-cell entities, and the lack of a clear immunophenotypic characteristic makes their identification hard. Flow cytometry turned out to be a useful tool in diagnosing T-cell disorders and to resolve complicated cases, especially if the number of analyzable neoplastic cells is small. We present a case of a 55-year-old man with simultaneous lymphoproliferative neoplastic T-cell clones, one αβ and the other γδ, identified and characterized by flow cytometry (FC), exploiting the variable expression intensity of specific markers. However, the patient’s rapid decline made it impossible to define a differential diagnosis in order to confirm the identity of the γδ clone, which remains uncertain. This case is added to the few other cases already documented in the literature, characterized by the co-existence of T-large granular lymphocytic leukemia (T-LGLL)-αβ and T-LGLL-γδ/Hepatosplenic T-cell lymphoma (HSTCL). Our case underlines the key role of sensitive diagnostic tools in the assessment of potential relationship between the diagnosis, prognosis, and treatment in the two pathologies. Full article

Incense burning is a significant source of indoor air pollution in many Asian regions. There is emerging evidence that maternal prenatal exposure to incense-burning smoke may be a risk factor for childhood obesity. We aimed to extend this new line of research by investigating the independent and joint effect of incense-burning smoke exposure, and children’s outdoor activity in early life, on preschoolers’ obesity. A total of 69,637 mother–child dyads were recruited from all kindergartens in the Longhua District of Shenzhen, China. Information on sociodemographic characteristics, maternal exposure to incense-burning smoke (IBS) during pregnancy, and frequency and duration of outdoor activity at the age of 1–3 years was collected by a self-administered questionnaire. In addition, the heights and weights of the children were measured by the research team. Logistic regression models and cross-over analyses were conducted to investigate the independent and combined effects of maternal exposure to incense-burning smoke during pregnancy and children’s early outdoor activity on obesity in preschoolers. We found that prenatal exposure to incense-burning smoke increased the risk of the presence of obesity in preschoolers’ (AOR = 1.13, 95% CI = 1.03–1.23). Additionally, lower frequencies (<3 times/week) or shorter durations (<60 min/time) of outdoor activity from the age of 1–3 years were significantly associated with the presence of obesity, with AORs of 1.24 (95% CI =1.18–1.32) and 1.11 (95% CI = 1.05–1.17), respectively. Furthermore, the cross-over analysis showed that prenatal exposure to IBS combined with a lower frequency of early outdoor activity (AOR = 1.47, 95% CI = 1.31–1.66) or a shorter duration of outdoor activity during ages of 1–3 years (AOR = 1.22, 95% CI = 1.07–1.39) increased the risk of obesity in preschoolers. Finally, additive interactions between prenatal exposure to IBS and postnatal outdoor activity on obesity were identified. Our study indicates that maternal exposure to incense-burning smoke during pregnancy and early lower postanal outdoor activity may independently and jointly increase the risk of obesity among preschoolers. Full article

We evaluated the persistence and efficacy of two different, in granulometry and content of diatoms, diatomaceous earth (DE) formulations (i.e., DE5 and DE6), against two major beetle species of stored products, i.e., Sitophilus oryzae (L.) (Coleoptera: Curculionidae) and Rhyzopertha dominica (F.) (Coleoptera: Bostrychidae). The formulations were applied as powders in soft wheat and maize in two doses of 500 and 1000 mg kg⁻¹ (ppm). Samples of the treated grains were taken on the day of application and every 30 days until completion of the six-month period of storage. Adults of S. oryzae and R. dominica were exposed to the treated grains at 25 °C and 55% relative humidity, and the mortality was measured after 7, 14, and 21 days of exposure. Rhyzopertha dominica survival was not affected by any combination of DE formulation, dose, and commodity. Contrariwise, the DEs caused significant adult mortality of S. oryzae, in most of the cases tested. We observed that DE6 was equally effective in both wheat and maize, and no considerable variations were observed in S. oryzae mortality during the 6-month experimental period. Furthermore, DE6 was more effective against S. oryzae than DE5, a difference that could have potentially contributed to the variations in the diatom granulometry between these two DEs. Thus, a DE treatment of 1000 ppm was shown to provide long-term protection of wheat and maize against S. oryzae, but this is strongly dependent on the DE formulation, commodity, and insect species. Overall, such natural resource-based inert silicaceous deposits could be used with success in stored-product protection with only some minor modifications, such as sieving and drying of the raw deposit. Full article

Walking encompasses a complex interplay of neuromuscular coordination and cognitive processes. Disruptions in gait can impact personal independence and quality of life, especially among the elderly and neurodegenerative patients. While traditional biomechanical analyses and neuroimaging techniques have contributed to understanding gait control, they often lack the temporal resolution needed for rapid neural dynamics. This study employs a mobile brain/body imaging (MoBI) platform with high-density electroencephalography (hd-EEG) to explore event-related desynchronization and synchronization (ERD/ERS) during overground walking. Simultaneous to hdEEG, we recorded gait spatiotemporal parameters. Participants were asked to walk under usual walking and dual-task walking conditions. For data analysis, we extracted ERD/ERS in α, β, and γ bands from 17 selected regions of interest encompassing not only the sensorimotor cerebral network but also the cognitive and affective networks. A correlation analysis was performed between gait parameters and ERD/ERS intensities in different networks in the different phases of gait. Results showed that ERD/ERS modulations across gait phases in the α and β bands extended beyond the sensorimotor network, over the cognitive and limbic networks, and were more prominent in all networks during dual tasks with respect to usual walking. Correlation analyses showed that a stronger α ERS in the initial double-support phases correlates with shorter step length, emphasizing the role of attention in motor control. Additionally, β ERD/ERS in affective and cognitive networks during dual-task walking correlated with dual-task gait performance, suggesting compensatory mechanisms in complex tasks. This study advances our understanding of neural dynamics during overground walking, emphasizing the multidimensional nature of gait control involving cognitive and affective networks. Full article

Denture stomatitis (DS) is a very common disease in wearers of removable complete and partial dentures with a worldwide prevalence in the range of 20–67%. Both industrially developed and impoverished nations are affected by the illness. DS is often associated with ill-fitting dentures or a fungal infection with Candida spp. Candida is normally found in the oral cavity microbiota, but it can be harmful to the health of elderly people with underlying diseases. Therefore, the purpose of the present study is to offer the most recent information about the epidemiology, etiology, and global distribution of Candida species associated with DS through a systematic review. Several databases, including Medline, Web of Science, and Scopus, were used to conduct an extensive search of the literature published in the previous 20 years. The selection of studies was performed by two authors. The extracted data were as follows: author, year of publication, country, sample, frequency of DS, method of diagnosing stomatitis, species of Candida, risk factors, and etiology of the disease. The JBI Critical appraisal tools were used to assess the quality of the studies. Eventually, twenty-eight studies were included in the systematic review. Twenty-one studies investigated DS, while seven studies examined Candida colonization in patients using removable dentures. The results show that the main causes of DS include the type of dentures, continuous wearing of dentures, and the formation of a Candida biofilm, which is facilitated by poor dental hygiene. Additionally, previous studies have pinpointed the significance of the salivary flow, saliva composition, and salivary pH. The findings of the current review indicate that it is crucial to monitor denture wearers for the appearance of DS, especially the patients whose immunity has been impaired due to a systemic condition. Finally, frequent follow-ups should include a clinical examination and microbial swabs of the palatal mucosa and the mucosal surface of the denture. Full article

A brand strategy is a powerful guarantee for a university to enhance its reputation and sustainable development. An internal brand is the foundation of a university brand. Based on three variables—internal market orientation, teachers’ organizational identity, and teachers’ brand support behavior, a research model is constructed on a university’s internal brand formation mechanisms. To summarize how teachers support the university’s internal brand building, we analyzed the relationship between the three variables. This study used a three-stage sampling survey method to distribute 500 questionnaires and recovered 419 valid samples. The data from the valid questionnaires were statistically analyzed using two software programs—SPSS 24.0 and Mplus 7.2. This survey and analysis found that the three internal market orientation dimensions (internal information collection, internal communication, and feedback) are significantly positively correlated with teachers’ organizational identity and brand support behavior. Teachers’ organizational identity is not only significantly positively correlated with brand support behavior, but also mediates the relationship between the three dimensions of internal market orientation and brand support behavior. Universities should pay attention to the key roles of teachers in brand building and regard internal market orientation as an important tool for internal brand building. Full article

Synthetic aperture radar tomography (TomoSAR) is an extension of synthetic aperture radar (SAR) imaging. It introduces the synthetic aperture principle into the elevation direction to achieve three-dimensional (3-D) reconstruction of the observed target. Compressive sensing (CS) is a favorable technology for sparse elevation recovery. However, for the non-sparse elevation distribution of the forested areas, if CS is selected to reconstruct it, it is necessary to utilize some orthogonal bases to first represent the elevation reflectivity sparsely. The iterative adaptive approach (IAA) is a non-parametric algorithm that enables super-resolution reconstruction with minimal snapshots, eliminates the need for hyperparameter optimization, and requires fewer iterations. This paper introduces IAA to tomographicinversion of the forested areas and proposes a novel multi-polarimetric-channel joint 3-D imaging method. The proposed method relies on the characteristics of the consistent support of the elevation distribution of different polarimetric channels and uses the $L_2$-norm to constrain the IAA-based 3-D reconstruction of each polarimetric channel. Compared with typical spectral estimation (SE)-based algorithms, the proposed method suppresses the elevation sidelobes and ambiguity and, hence, improves the quality of the recovered 3-D image. Compared with the wavelet-based CS algorithm, it reduces computational cost and avoids the influence of orthogonal basis selection. In addition, in comparison to the IAA, it demonstrates greater accuracy in identifying the support of the elevation distribution in forested areas. Experimental results based on BioSAR 2008 data are used to validate the proposed method. Full article

Four types of perfluoroarene-substituted and the corresponding non-fluorinated Pt(II) complexes, [PtCl₂L] (L = 1 and 2), were prepared with 4,4′-bis(pentafluorophenyl)-2,2′-bipyridine (1a), 4,4′-diphenyl-2,2′-bipyridine (1b), 4,4′-bis(2-pentafluorophenylethynyl)-2,2′-bipyridine (2a), and 4,4′-bis(2-phenylethynyl)-2,2′-bipyridine (2b), respectively, to understand the role of perfluoroaromatic substitution and acetylene linkers on molecular structures and their induced supramolecular associations. The pentafluorophenyl groups lead to significant changes in electron distribution within the Pt(II) complexes, notably causing absorption bands to red-shift due to a metal-to-ligand charge transfer from nucleophilic platinum ions and demonstrating stabilization effects on the bands by fluorination in experimental and theoretical studies. The results of altering electron density and reducing the metal’s nucleophilic tendencies through fluorination and the use of an acetylene linker are discussed, accompanied by crystal structures, the corresponding Hirshfeld surface analysis, and DFT calculations. Full article

The contamination of food by microplastics has garnered widespread attention, particularly concerning the health risks associated with small-sized microplastics. However, detecting these smaller microplastics in food poses challenges attributed to the complexity of food matrices and instrumental and method limitations. Here, we employed Raman imaging for visualization and identification of polystyrene particles synthesized in polymerization reactions, ranging from 400 to 2600 nm. We successfully developed a quantitative model of particle size and concentration for polystyrene, exhibiting excellent fit (R² of 0.9946). We established procedures for spiked flavored yogurt using synthesized polystyrene, providing fresh insights into microplastic extraction efficiency. Recovery rates calculated from models validated the method’s feasibility. In practical applications, the assessment of the size, type, shape, and quantity of microplastics in unspiked flavored yogurt was conducted. The most common polymers found were polystyrene, polypropylene, and polyethylene, with the smallest polystyrene sizes ranging from 1 to 10 μm. Additionally, we conducted exposure assessments of microplastics in branded flavored yogurt. This study established a foundation for developing a universal method to quantify microplastics in food, covering synthesis of standards, method development, validation, and application. Full article

Landslides play a significant role in the morpho-evolutional processes of slopes, affecting them globally under various geological conditions. Often unnoticed due to low velocities, they cause diffuse damage and loss of economic resources to the infrastructure or villages built on them. Recognizing and mapping mass movements is crucial for mitigating economic and social impacts. Conventional monitoring techniques prove challenging for large areas, necessitating resource-intensive ground-based networks. Leveraging abundant synthetic aperture radar (SAR) sensors, satellite techniques offer cost-effective solutions. Among the various methods based on SAR products for detecting landslides, multi-temporal differential interferometry SAR techniques (MTInSAR) stand out for their precise measurement capabilities and spatiotemporal evolution analysis. They have been widely used in several works in the last decades. Using information from the official Italian landslide database (IFFI), this study employs Sentinel-1 imagery and two new processing chains, E-PS and E-SBAS algorithms, to detect deformation areas on the slopes of Calitri, a small town in Southern Italy; these algorithms assess the cumulated displacements and their state of activity. Taking into account the non-linear trends of the scatterers, these innovative algorithms have helped to identify a dozen clusters of points that correspond well with IFFI polygons. Full article

The tracking of carbon and aerosol co-emissions is essential for environmental management. Satellite-based atmospheric synoptic observation networks provide large-scale and multifaceted data to help resolve emission behaviors. This study employs a comprehensive analysis of atmospheric dynamics, combustion byproducts, and aerosol characteristics around power plants. Strong correlations between Aerosol Optical Depth (AOD) at 500 nm and the column-averaged dry-air mole fraction of carbon dioxide (XCO${}_2$) were observed, revealing synchronous peaks in their emission patterns. The investigation into combustion completeness utilized metrics such as the ratio of carbon monoxide (CO)/XCO${}_2$ and Black Carbon Extinction (BCEXT)/Total Aerosol Extinction (TOTEXT). Discrepancies in these ratios across cases suggest variations in combustion efficiency and aerosol characteristics. Nitrogen dioxide (NO${}_2$) distributions closely mirrored XCO${}_2$, indicating consistent emission patterns, while variations in sulfur dioxide (SO${}_2$) distributions implied differences in sulfide content in the coal used. The influence of coal composition on AOD/XCO${}_2$ ratios was evident, with sulfide content contributing to variations besides combustion efficiency. This multifactorial analysis underscores the complex interplay of combustion completeness, aerosol composition, and coal components in shaping the air quality around power stations. The findings highlight the need for a nuanced understanding of these factors for effective air quality management. Full article

The described data set contains features from the machine control of a five-axis milling machine. The features were recorded during thirteen series productions. Each series production includes a changeover process in which the machine was set up for the production of a different product. In addition to the timestamps and the twenty recorded features derived from Numerical Control (NC) variables, the data set also contains labels for the different production phases. For this purpose, up to 23 phases were assigned, which are based on a generalized milling process. The data set consists of thirteen .csv files, each representing a series production. The data set was recorded in a production company in the contract manufacturing sector for components with real series orders in ongoing industrial production. Full article

Epidermal growth factor (EGF), an essential factor for the proliferation and survival of renal tubular cells, is expressed by distal tubules and normally excreted via urine. Previous studies in rats demonstrated that acute tubular injury reduces urinary EGF levels. However, it is unclear whether urinary EGF is a suitable monitoring marker of tubular repair status after acute kidney injury (AKI) in humans. To address this question, we measured serum and urinary EGF in patients with AKI (n = 99) using ELISA and investigated whether urinary EGF levels were associated with the severity of tubular injury and renal prognosis. Urinary EGF was abundant in healthy controls but showed a significant decrease in AKI patients (14,522 ± 2190 pg/mL vs. 3201 ± 459.7 pg/mL, p < 0.05). The urinary EGF level in patients with renal AKI was notably lower than that in patients with pre-renal AKI. Furthermore, the urinary EGF level in patients with AKI stage 3 was significantly lower than that in patients with AKI stage 1. Urinary EGF levels were negatively correlated with urinary β-2MG and serum creatinine levels but positively correlated with hemoglobin levels and eGFR. Urinary EGF was not significantly correlated with urinary NAG, α-1MG, L-FABP, NGAL, KIM-1, or urinary protein concentrations. No significant correlation was observed between serum and urinary EGF levels, suggesting that urinary EGF is derived from the renal tubules rather than the blood. In living renal transplantation donors, the urinary EGF/Cr ratio was approximately half the preoperative urinary EGF/Cr ratio after unilateral nephrectomy. Collectively, these data suggest that urinary EGF is a suitable noninvasive indicator of not only the volume of functional normal renal tubules but also the status of tubular repair after AKI. Full article

The recent description of well-defined molecular subtypes of breast cancer has led to the clinical development of a number of successful molecular targets. Particularly, triple-negative breast cancer (TNBC) is an aggressive type of breast cancer with historically poor outcomes, mainly due to the lack of effective targeted therapies. Recent progresses in materials science have demonstrated the impressive properties of metal–organic framework nanoparticles (NPs) as antitumoral drug delivery systems. Here, in a way to achieve efficient bio-interfaces with cancer cells and improve their internalization, benchmarked MIL-100(Fe) NPs were coated with cell membranes (CMs) derived from the human TNBC cell line MDA-MB-468. The prepared CMs-coated metal–organic framework (CMs_MIL-100(Fe)) showed enhanced colloidal stability, cellular uptake, and cytotoxicity in MDA-MB-468 cells compared to non-coated NPs, paving the way for these human CMs-coated MIL-100(Fe) NPs as effective targeted therapies against the challenging TNBC. Full article

This comprehensive review explores the intricate aspects of left ventricular thrombus (LVT), a potential complication in both ischemic and non-ischemic cardiomyopathies. It provides a thorough understanding of left ventricular thrombus, revealing its uncommon incidence in the general population (7 cases per 10,000 patients), predominantly linked to ischemic heart diseases (ICMs) at an 80% prevalence rate. Diagnostic tools, notably transthoracic echocardiography (TTE) and cardiac magnetic resonance imaging (CMR), demonstrate varying sensitivity but remain indispensable in specific clinical contexts related to LVT as non-invasive diagnostic modalities. A detailed comparison between ICM patients and those with non-ischemic cardiomyopathy (NICM) who have left ventricular thrombus reveals subtle distinctions with significant clinical implications. This analysis underscores the importance of these imaging techniques in distinguishing between the two conditions. Additionally, we explored the occurrence of LVT in specific non-ischemic cardiomyopathies, including Takotsubo syndrome, hypertrophic cardiomyopathy, eosinophilic myocarditis, Chagas disease, cardiac amyloidosis, and several other conditions. The article further delves into anticoagulation strategies, thoroughly examining their impact on LVT regression and patient outcomes. Pharmacological interventions, with a focus on direct oral anticoagulants, emerge as promising alternatives; however, there is insufficient information on their efficiency and safety, especially in NICM population. In conclusion, this review highlights the complex nature of LVT, incorporating a range of etiopathogenic factors, diagnostic complexities, and evolving therapeutic approaches. It emphasizes the pressing need for ongoing research in this field. Full article

Smallholder farmers in Malawi largely depend on rainfed agriculture, despite climate change posing serious threats to this form of agriculture. The adoption of climate-smart agricultural practices is pivotal in offsetting the effects of climate change on agriculture. Despite the great potential of climate-smart agricultural practices in combating the effects of climate change on agriculture, smallholder farmers’ adoption of it remains low. Reasons are varied, suggesting that the factors are largely contextual. This study, therefore, explored the determinants of smallholder farmers’ adoption of climate-smart agricultural practices in Zomba, within the framework of the diffusion of innovations. Using a convergent mixed research design, the study purposively selected key informants and randomly selected smallholder farmers. Questionnaires, interviews, and observation guides were used to collect data. Thematic analysis was used to analyse qualitative data, while descriptive analysis was used to analyse quantitative data. Results indicate that only 26% of smallholder farmers have adopted the promoted climate-smart agricultural practices. Compatibility and simplicity are the chief determinants of climate-smart agricultural practice adoption. The majority of smallholder farmers fall under the late majority. Evidence shows that labour and capital intensive climate-smart agricultural practices are less likely to be adopted by smallholder farmers. Implementing agencies, therefore, should first consult the local farmers on the ground to see practices that are already being followed and are suitable before bringing the new ones. This will ensure that the appropriate climate-smart agricultural practices are promoted. Full article

Glioblastoma Multiforme is a brain tumor distinguished by its aggressiveness. We suggested that this aggressiveness leads single-cell RNA-sequence data (scRNA-seq) to span a representative portion of the cancer attractors domain. This conjecture allowed us to interpret the scRNA-seq heterogeneity as reflecting a representative trajectory within the attractor’s domain. We considered factors such as genomic instability to characterize the cancer dynamics through stochastic fixed points. The fixed points were derived from centroids obtained through various clustering methods to verify our method sensitivity. This methodological foundation is based upon sample and time average equivalence, assigning an interpretative value to the data cluster centroids and supporting parameters estimation. We used stochastic simulations to reproduce the dynamics, and our results showed an alignment between experimental and simulated dataset centroids. We also computed the Waddington landscape, which provided a visual framework for validating the centroids and standard deviations as characterizations of cancer attractors. Additionally, we examined the stability and transitions between attractors and revealed a potential interplay between subtypes. These transitions might be related to cancer recurrence and progression, connecting the molecular mechanisms of cancer heterogeneity with statistical properties of gene expression dynamics. Our work advances the modeling of gene expression dynamics and paves the way for personalized therapeutic interventions. Full article

Phytochemical profiling followed by antimicrobial and anthelmintic activity evaluation of the Australian plant Geijera parviflora, known for its customary use in Indigenous Australian ceremonies and bush medicine, was performed. In the present study, seven previously reported compounds were isolated including auraptene, 6′-dehydromarmin, geiparvarin, marmin acetonide, flindersine, and two flindersine derivatives from the bark and leaves, together with a new compound, chlorogeiparvarin, formed as an artifact during the isolation procedure and isolated as a mixture with geiparvarin. Chemical profiling allowed for a qualitative and quantitative comparison of the compounds in the leaves, bark, flowers, and fruit of this plant. Subsequently, a subset of these compounds as well as crude extracts from the plant were evaluated for their antimicrobial and anthelmintic activities. Anthelmintic activity assays showed that two of the isolated compounds, auraptene and flindersine, as well as the dichloromethane and methanol crude extracts of G. parviflora, displayed significant activity against a parasitic nematode (Haemonchus contortus). This is the first report of the anthelmintic activity associated with these compounds and indicates the importance of such fundamental explorations for the discovery of bioactive phytochemicals for therapeutic application(s). Full article

This article is about a framework for determining the degree of realism of any given passenger ride motion discomfort measurement formula. After providing some context and reviewing evidence of deficiency in currently popular ride motion discomfort measurement formulas, the article outlines the research program that needs to be carried out in order to establish such a framework. The research begins with gathering recordings of uncomfortable ride motion episodes encountered in a chosen type of passenger transport service. It then has test subjects compare the episodes via a ride motion simulator and adjust their amplitudes pair wise until they cause equal discomfort. It explains how to take the pair wise amplitude adjustments and determine amplitude adjustments that bring all of the motion episode recordings to a common level of discomfort so that they form a normalized set. Then, the lower the scatter of the scores assigned by any given discomfort measurement formula to the members of that set, the more realistic that formula will be for the chosen service. Full article