In real estate valuation using the Hedonic Price Model (HPM) estimated via Ordinary Least Squares (OLS) regression, subjectivity and measurement errors in the independent variables violate the Gauss–Markov theorem assumption of a non-random coefficient matrix, leading to biased parameter estimates and incorrect precision assessments. In this contribution, the Errors-in-Variables model equipped with Total Least Squares (TLS) estimation is proposed to address these issues. It fully considers random errors in both dependent and independent variables. An iterative algorithm is provided, and posterior accuracy estimates are provided to validate its effectiveness. Monte Carlo simulations demonstrate that TLS provides more accurate solutions than OLS, significantly improving the root mean square error by over 70%. Empirical experiments on datasets from Boston and Wuhan further confirm the superior performance of TLS, which consistently yields a higher coefficient of determination and a lower posterior variance factor, which shows its more substantial explanatory power for the data. Moreover, TLS shows comparable or slightly superior performance in terms of prediction accuracy. These results make it a compelling and practical method to enhance the HPM. Full article

Background: Despite the encouragement of early initiation and titration of guideline-di-rected medical therapy (GDMT) for the treatment of heart failure (HF), most patients do not receive an adequate type and dose of pharmacotherapy in the real world. Objectives: This study aimed to determine the efficacy of titrating composite GDMT in patients with HF with reduced and mildly reduced ejection fraction and to identify patient conditions that may benefit from titration of GDMT. Methods: This was a two-center, retrospective study of consecutive patients hospitalized with acute decompensated heart failure (ADHF). Patients were classified into two groups according to a scoring scale determined by combination and doses of four types of HF agents (ACEis/ARBs/ARNis, BBs, MRAs, and SGLT2is) at discharge. A score of 5 or greater was defined as titrated GDMT, and a score of 4 or less was regarded as sub-optimal medical therapy (MT). Results: A total of 979 ADHF patients were screened. After 553 patients were excluded based on exclusion criteria, 426 patients (90 patients in the titrated GDMT group and 336 patients in the sub-optimal MT group) were enrolled for the analysis. The median follow-up period was 612 (453–798) days. Following statistical adjustment using the propensity score weighting method, the 2-year composite endpoint (composite of cardiac death and HF rehospitalization) rate was significantly lower in the titrated GDMT group, at 19%, compared with the sub-optimal MT group: 31% (score 3–4 points) and 43% (score 0–2 points). Subgroup analysis indicated a marked benefit of titrated GDMT in particular patient subgroups: age < 80 years, BMI 19.0–24.9, eGFR > 20 mL/min/1.73 m², and serum potassium level ≤ 5.5 mmol/L. Conclusions: Prompt initiation and dose adjustment of multiple HF medications, with careful monitoring of the patient’s physiologic and laboratory values, is a prerequisite for improving the prognosis of patients with heart failure. Full article

Due to its variety of signs and symptoms, there have been numerous attempts to treat fibromyalgia (FM), but a cure has yet to be established. The aim of this study was to evaluate the effects of a complex kinetic therapy program and a combined physical modality program on pain and other common symptoms of FM. Patients and methods: A total of 78 female patients were included in this study; 39 subjects underwent a kinesiotherapy (KT) intervention (combining aerobic and Pilates exercises), and 39 participated in a physical modality (PM) program (including electrotherapy (TENS and low-laser therapy) and thermotherapy). Results: Regarding the parameter of pain assessment, kinesiotherapy demonstrated its superiority both during the treatment period and in the evaluation 3 months after therapy cessation. Both in terms of patient-reported pain (inter-group comparisons: p = 0.000 at T3) and the examination of tender points (inter-group comparisons: p = 0.000 at T3), as well as the algometric assessment, pain was alleviated by the two forms of applied kinetic therapy. The observed functional impairment was statistically significantly influenced (p = 0.001) at the end of the kinetic program application, while for the perceived functional impairment, neither therapy proved superiority over the other at any point of evaluation (inter-group comparisons: p = 0.715 at T3). Regarding the influence of the emotional consequences implied by fibromyalgia, neither the forms of kinesiotherapy nor the chosen physical modalities proved superiority at any point of evaluation (HAQ anxiety inter-group comparisons: p = 0.000 at T3). In conclusion, even though kinesiotherapy had superior influences on fibromyalgia pain in the studied group, the current research lends credence to the significance of non-pharmacological therapy in managing fibromyalgia. Participants demonstrated positive advancements in subjective and objective pain assessments, as well as improvements in functional and emotional well-being. Full article

This study aimed to assess the viability of utilizing lime–fly ash (LF) and red mud (RM) in the modification of silty soil (LF-RMS) for subgrade filling. The primary objective of this research was to analyze the mechanical characteristics and examine the curing mechanisms associated with said modified materials. Different curing times were utilized in the analysis of mechanical properties (e.g., via unconfined compression testing), microstructure (via scanning electron microscopy, X-ray diffraction, and thermogravimetric-differential thermal analysis), and environmental indices (via assessment of corrosivity, heavy metal concentration, and radioactivity) with various dosages of red mud (D_RM) and Lime–fly ash (D_LF). Analyses of the curing mechanisms, failure modes, microstructures, and degrees of environmental impact associated with LF-RMS were also undertaken. The tests indicated that the unconfined compressive strength (UCS) exhibited an initial increase followed by a decrease as the D_RM and D_LF levels increased. Additionally, the strength of LF-RMS increased with an increase in curing time. It is worth noting that the specimen composed of 20% LF and 23% RM (D_20%LF+23%RM) demonstrated a maximum UCS value of 4.72 MPa after 90 days of curing, which indicates that it has the strongest ability to resist deformation. The strength of the specimen cured for 90 days was 1.4 times higher than that of the specimen cured for 7 days (1.97 MPa). Furthermore, the toxic concentration and radionuclide index of LF-RMS were significantly reduced compared to those of pure RM. The overall concentration of heavy metals in the D_20%LF+23%RM specimen decreased by more than 60% after curing for 28 days. The internal irradiation index and the external irradiation index decreased by 1.63 and 1.69, respectively. The hydration products in LF-RMS play a key role in the solidification of heavy metals, and the alkaline environment provided by RM also contributes to the precipitation and replacement of heavy metals. In this study, red mud, fly ash and lime were used to modify silty soil. The central tenets of sustainable development may be achieved through the reuse of RM as a road filler. Full article

The flowability and mechanical properties are increasingly crucial in the filling process of deep metal mines with mining depths exceeding 1000 m. The rheological properties of filling slurry in the pipeline were analyzed through rheological tests, L-tube self-flow tests, and semi-industrial loop tests. The results revealed that with an increase in the cement-to-tailings mass ratio (c/t ratio) and mass concentration, the slurry exhibited a higher flow resistance and decreased stowing gradient. During slurry transportation, the pressure loss in the straight pipe was positively correlated with the slurry flow rate, c/t ratio, and mass concentration. A uniaxial compressive strength (UCS) test was conducted to analyze the mechanical properties of the cemented paste backfill containing BMC (CCPB) in both standard and deep-underground curing environments. The UCS of the CCPB showed an increasing trend with the rise in curing age, mass concentration, and the c/t ratio. The comprehensive analysis concluded that when the c/t ratio is 1:4, and the mass concentration is approximately 74%, and parameters such as the slump, bleeding rate, and flowability of the filling slurry meet the criteria for conveying and goaf filling, resulting in a high-strength filling body. Full article

In 2013, during Typhoon Soulik, wind data were collected at various heights above the ground (15, 27, 53, 67, and 82 m) on the 550 kV 52# pole transmission tower in Ningde City, Fujian Province. The wind speed profile, turbulence intensity, gust factor, crest factor, and power spectrum were analyzed using 10 min interval wind speed records. The results show the following: (1) the average wind velocity of Typhoon Soulik varies in accordance with both the power law and the logarithmic law, but the Deaves–Harris model exhibits significant discrepancies; (2) the turbulence intensity in $u$, $v$, and $w$ orientations decreases with the average wind velocity at each height. Exponential fitting is conducted on the strength of turbulence and gust factor profiles in each direction based on the standards of different countries, resulting in the derivation of empirical expressions; (3) the integral scale components of turbulence in $u$, $v$, and $w$ orientations exhibit a positive correlation with both average wind velocity and height. The turbulence integral scale ratios in the longitudinal, transverse, and vertical directions at heights of 15, 53, and 82 m are 1:0.68:0.11, 1:0.67:0.27, and 1:0.67:0.30, respectively; (4) the Von Karman empirical spectrum and the modified Kaimal cross-spectrum model closely match the observed wind power spectrum of Typhoon Soulik. The presented results contribute to furthering references for wind-resistant design of structures in typhoon-prone areas and prevention of typhoon-related disasters. Full article

The number of battery systems is also growing significantly along with the rise in electric and hybrid car sales. Different vehicles use different types and numbers of batteries. Furthermore, the layout and operation of the control and protection electronics units may also differ. The research aims to develop an approach that can autonomously detect and localize the weakest cells. The method was validated by testing the battery systems of three different VW e-Golf electric vehicles. A wide-range discharge test was performed to examine the condition assessment and select the appropriate state of charge (SoC) for all three vehicles. On the one hand, the analysis investigated the cell voltage deviations from the average; the tests cover deviations of 0 mV, 12 mV, 60 mV, 120 mV, and 240 mV. On the other hand, the mean value calculation was used to filter out possible erroneous values. Another important aspect was examining the relationship between the state of charges (SoC) and the deviations. Therefore, the 10% step changes were tested to see which SoC level exhibited more significant voltage deviations. Based on the results, it was observed that there are differences between the cases, and the critical range is not necessarily at the lowest SoC level. Furthermore, the load rate (current) and time of its occurrence play an important role in the search for a faulty cell. An additional advantage of this approach is that the process currently being tested on the VW e-Golf can be relatively simply transferred to other types of vehicles. It can also be a very useful addition for autonomous vehicles, as it can self-test the cells in the system at low power consumption. Full article

Mechanical stimulation is prevalent within organisms, and appropriate regulation of such stimulation can significantly enhance cellular functions. Consequently, the in vitro construction and simulation of mechanical stimulation have emerged as a research hotspot in biomechanics. In recent years, a class of artificial muscles named electroactive polymers (EAPs), especially ionic EAPs, have shown promising applications in biomechanics. While several techniques utilizing ionic EAPs for cell mechanical stimulation have been reported, further research is needed to advance and enhance their practical applications. Here, we prepared a microactuator array based on ionic EAP artificial muscles for cell mechanical stimulation. As a preliminary effort, we created a 5 × 5 microactuator array on a supporting membrane by employing laser cutting. We evaluated the electro-actuation performance of the microactuators through experimental testing and numerical simulations, affirming the potential use of the microactuator array for cell mechanical stimulation. The devised approach could inspire innovative design concepts in the development of miniaturized intelligent electronic devices, not only in biomechanics and biomimetics but also in other related fields. Full article

Alcohol is toxic to neurons and can trigger alcohol-related brain damage, neuronal loss, and cognitive decline. Neuronal cells may be vulnerable to alcohol toxicity and damage from oxidative stress after differentiation. To consider this further, the toxicity of alcohol to undifferentiated SH-SY5Y cells was compared with that of cells that had been acutely differentiated. Cells were exposed to alcohol over a concentration range of 0‒200 mM for up to 24 h and alcohol effects on cell viability were evaluated via MTT and LDH assays. Effects on mitochondrial morphology were examined via transmission electron microscopy, and mitochondrial functionality was examined using measurements of ATP and the production of reactive oxygen species (ROS). Alcohol reduced cell viability and depleted ATP levels in a concentration- and exposure duration-dependent manner, with undifferentiated cells more vulnerable to toxicity. Alcohol exposure resulted in neurite retraction, altered mitochondrial morphology, and increased the levels of ROS in proportion to alcohol concentration; these peaked after 3 and 6 h exposures and were significantly higher in differentiated cells. Protein carbonyl content (PCC) lagged behind ROS production and peaked after 12 and 24 h, increasing in proportion to alcohol concentration, with higher levels in differentiated cells. Carbonylated proteins were characterised by their denatured molecular weights and overlapped with those from adult post-mortem brain tissue, with levels of PCC higher in alcoholic subjects than matched controls. Hence, alcohol can potentially trigger cell and tissue damage from oxidative stress and the accumulation of oxidatively damaged proteins. Full article

Robot-assisted surgical systems have been widely applied for minimally invasive needle biopsies thanks to their excellent accuracy and superior stability compared to manual surgical operations, which lead to possible fatigue and misoperation due to long procedures. Current needle biopsy robots are normally customed designed for specific application scenarios, and only position-level kinematics are derived, preventing advanced speed control or singularity analysis. As a step forward, this paper aims to design a universal needle biopsy robot platform which features 6 DoF 3-RRRS (Revolute–Revolute–Revolute–Spherical) parallel structure. The analytical solutions to its nonlinear kinematic problems, including forward kinematics, inverse kinematics, and differential kinematics are derived, allowing fast and accurate feedback control calculations. A multibody simulation platform and a first-generation prototype are established next to provide comprehensive verifications for the derived robotic model. Finally, simulated puncture experiments are carried out to illustrate the effectiveness of the proposed method. Full article

In trainable wireless communications systems, the use of deep learning for over-the-air training aims to address the discontinuity in backpropagation learning caused by the channel environment. The primary methods supporting this learning procedure either directly approximate the backpropagation gradients using techniques derived from reinforcement learning, or explicitly model the channel environment by training a generative channel model. In both cases, over-the-air training of transmitter and receiver requires a feedback channel to sound the channel environment and obtain measurements of the learning objective. The use of continuous feedback not only demands extra system resources but also makes the training process more susceptible to adversarial attacks. Conversely, opting for a feedback-free approach to train the models over the forward link, exclusively on the receiver side, could pose challenges to reliably end the training process without intermittent testing over the actual channel environment. In this article, we propose a novel method for the over-the-air training of wireless communication systems that does not require a feedback channel to train the transmitter and receiver. Random samples are transmitted through the channel environment to train a mixture density network to approximate the channel distribution on the receiver side of the network. The transmitter and receiver models are trained with the resulting channel model, and the transmitter can be deployed after training. We show that the block error rate measurements obtained with the simulated channel are suitable for monitoring as a stopping criterion during the training process. The resulting method is demonstrated to have equivalent performance to the end-to-end autoencoder training on small message sequences. Full article

Olmesartan medoxomil (OLM) is a selective angiotensin II receptor antagonist used in the treatment of hypertension. Its therapeutic potential is limited by its poor water solubility, leading to poor bioavailability. Encapsulation of the drug substance by two methylated cyclodextrins, namely randomly methylated β-cyclodextrin (RM-β-CD) and heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin (TM-β-CD), was carried out to overcome the limitation related to OLM solubility, which, in turn, is expected to result in an improved biopharmaceutical profile. Supramolecular entities were evaluated by means of thermoanalytical techniques (TG—thermogravimetry; DTG—derivative thermogravimetry), spectroscopic methods including powder X-ray diffractometry (PXRD), universal-attenuated total reflectance Fourier-transform infrared (UATR-FTIR) and UV spectroscopy, saturation solubility studies, and by a theoretical approach using molecular modeling. The phase solubility method reveals an A_L-type diagram for both inclusion complexes, indicating a stoichiometry ratio of 1:1. The values of the apparent stability constant indicate the higher stability of the host–guest system OLM/RM-β-CD. The physicochemical properties of the binary systems are different from those of the parent compounds, emphasizing the formation of inclusion complexes between the drug and CDs when the kneading method was used. The molecular encapsulation of OLM in RM-β-CD led to an increase in drug solubility, thus the supramolecular adduct can be the subject of further research to design a new pharmaceutical formulation containing OLM, with improved bioavailability. Full article

Ergonomic risks critically impact workers’ occupational health, safety, and productivity, and thereby the sustainability of a workforce. In the construction industry, the physical demands and dynamic environment exposes workers to various ergonomic hazards. While previous research has mainly focused on postural risks, there is a need to broaden the scope to include more relevant factors and assess them systematically. This study introduces a multi-criteria decision framework integrating the Spherical Fuzzy Sets (SFSs) and Alternative Queuing Method (AQM) to evaluate and prioritize ergonomic hazards. First, SFSs are employed to quantify the linguistic expressions of experts, addressing the inherent vagueness and uncertainty. Then, an entropy-based objective weighting method is adopted to determine the criteria weights. Finally, AQM is utilized to generate the risk priority. The proposed method has been implemented in a real-life construction project, where “overexertion due to unreasonable task organization”, “hypertension and heart diseases”, and “existing WMSD record” are identified as the top three ergonomic hazards. Then, a thorough discussion of intervention strategies regarding different risk categories is presented to facilitate ergonomic interventions. This proposed decision support system can promote effective ergonomic risk management, benefiting workers’ health and well-being and contributing to the sustainable workforce development of the construction industry. Full article

Diarrhea is the most common issue in sheep farms, typically due to pathogenic Escherichia coli (E. coli) infections, such as E. coli F17. microRNA, a primary type of non-coding RNA, has been shown to be involved in diarrhea caused by pathogenic E. coli. To elucidate the profound mechanisms of miRNA in E. coli F17 infections, methods such as E. coli F17 adhesion assay, colony counting assay, relative quantification of bacterial E. coli fimbriae gene expression, indirect immune fluorescence (IF), Cell Counting Kit-8 (CCK-8), 5-ethynyl-2′-deoxyuridine (EdU), Western blotting (WB), and scratch assay were conducted to investigate the effect of miR-329b-5p overexpression/knock-down on E. coli F17 susceptibility of sheep intestinal epithelial cells (IECs). The findings indicated that miR-329b-5p enhances the E. coli F17 resistance of sheep IECs to E.coli F17 by promoting adhesion between E. coli F17 and IEC, as well as IEC proliferation and migration. In summary, miR-329b-5p plays a crucial role in the defense of sheep IECs against E. coli F17 infection, providing valuable insights into its mechanism of action. Full article

The act of land transfer in rural areas is an important decision-making mechanism for farmers, to enhance resource allocation efficiency and promote capital mobility, and this act is of strategic importance in promoting the level of agricultural scale and mechanization, land system change, and, thus, the sustainable development of livelihoods and production in China. This study aims to explore farmers’ decision-making mechanisms in the process of land transfer in rural areas, by constructing a theoretical framework. Structural equation modeling was used, based on data from a survey of rural families in the Liaoning Province area of Northeastern China. The main findings are as follows: (1) The seven types of exogenous latent variables, including environmental vulnerability, policy, and five main livelihood assets (natural capital, physical capital, financial capital, human capital, and social capital), are intermediary in farmers’ land transfer behavior, which then positively affect farmers’ livelihood outcomes. (2) Among the exogenous latent variables affecting farmers’ land transfer, human assets have the most significant positive effect, followed by social assets and physical assets, family labor force share, frequency of work information exchange, and number of production tools, greatly affect the corresponding variable. (3) Natural assets play the most important role and have a negative effect on farmers’ land transfer decision; contracted area of land per family is the greatest impacted measurable variable of this. The results of the study suggest that the government should strengthen skills training for farmers, improve the land transfer policy system, and provide appropriate subsidies in a regionally targeted manner. Thus, it can promote the transformation of Chinese-style agricultural modernization and achieve rural revitalization. Full article

The generation of images from electroencephalography (EEG) signals has become a popular research topic in recent research because it can bridge the gap between brain signals and visual stimuli and has wide application prospects in neuroscience and computer vision. However, due to the high complexity of EEG signals, the reconstruction of visual stimuli through EEG signals continues to pose a challenge. In this work, we propose an EEG-ConDiffusion framework that involves three stages: feature extraction, fine-tuning of the pretrained model, and image generation. In the EEG-ConDiffusion framework, classification features of EEG signals are first obtained through the feature extraction block. Then, the classification features are taken as conditions to fine-tune the stable diffusion model in the image generation block to generate images with corresponding semantics. This framework combines EEG classification and image generation means to enhance the quality of generated images. Our proposed framework was tested on an EEG-based visual classification dataset. The performance of our framework is measured by classification accuracy, 50-way top-k accuracy, and inception score. The results indicate that the proposed EEG-Condiffusion framework can extract effective classification features and generate high-quality images from EEG signals to realize EEG-to-image conversion. Full article

In this study, an Al₂O₃-40TiO₂ coating was deposited on 20MnNiMo steel via atmospheric plasma spraying. The corrosion behavior of the coating was investigated in both artificial seawater and a simulated environment with hydrogen sulfide and high pressure. Additionally, ion dissolution experiments were conducted to evaluate the coating’s bio-friendliness. In artificial seawater, the corrosion rate (based on the corrosion current) of the Al₂O₃-40TiO₂ coating initially decreased before increasing. It was speculated that the blocking of corrosion products in the defect channels was helpful in delaying the progress of corrosion in the early stage. The coating had a corrosion current on the order of 10⁻⁶ A/cm² in artificial seawater, suggesting good protection in conventional seawater environments. In the simulated environment, the corrosion rate (based on the weight loss) of the Al₂O₃-40TiO₂ coating showed a continuously declining trend. It was deduced that, unlike corrosion products in artificial seawater, the corrosion products in the simulated environment (e.g., metal sulfide) might be more chemically stable, leading to a longer blocking effect. Therefore, a minimal corrosion rate of 0.0030 mm/a was obtained after the coating was immersed for 30 days. The amount of dissolved coated elements was negligible and there were only small amounts of dissolved non-coated elements such as Ni and Mo. The developed coating can be considered to be highly biofriendly if the non-coated area of the specimen is well sealed. Full article

Motorcycle motion is largely influenced by the road geometry, which alters the allowable accelerations in longitudinal and lateral directions and influences the vertical wheel loads. Recently, a method for three-dimensional road reconstruction and its incorporation into transient and quasi-steady-state (QSS) minimum lap time simulations (MLTSs) has been proposed. The main purpose of this work is to demonstrate how significantly different results from a minimum lap time optimal control problem can be obtained when using inappropriate elevation data sources in the track reconstruction problem, and how the road model reconstructed using poor input data can lead to misleading conclusions when analyzing real vehicle and driver performances. Two road models derived from high- and low-resolution digital elevation models (DEMs) are compared and their impact on the optimal maneuver of a racing motorcycle is examined. The essentials of track identification are presented, as well as vehicle positioning on the 3D road and the generalized QSS motorcycle model. Obtained 3D and 2D road models are analyzed in detail, on a case example of the Road Atlanta racetrack, and used in minimum lap time simulations, which are validated by the experimental data recorded on the Supersport motorcycle. The comparative analysis showed that great care should be taken when selecting the elevation dataset in the track reconstruction process, and that the 1 m resolution local DEMs seem to be sufficient to obtain MLTS results close to the measured ones. The example of using the 3D free-trajectory QSS minimum lap time problem to localize the track segments where real driver actions can be improved is also presented. The differences between simulation results on different road models of the same racetrack can be large and influence the interpretation of optimal maneuver. Full article

The use of color dyes in modern society presents a great challenge to the environment. Thus, extensive studies have been conducted in the last 30 years on the removal of color dyes from aqueous solutions such industrial wastewater. In this study, the removal of alizarin red S (ARS), an anionic dye, from solution by raw calcite (Cal) and heat-treated calcite (HCal) was conducted and compared under different physico-chemical conditions. Based on the isotherm study, the ARS removal capacities increased from 167 to 251 mmol/kg after the Cal was heated to 1000 °C for 3 h. The X-ray diffraction analyses showed no difference in the calcite phase between Cal and HCal after ARS sorption. Fourier-transform infrared results also showed no change in the calcite phase after ARS sorption, except a slightly increase in wavenumber from 713 to 727 cm⁻¹ for the OCO bending of HCal at high ARS sorption levels. SEM observations showed about the same particle size and morphology before and after ARS sorption. The TGA data showed the formation of CaO after Cal was heated, and CaO converted back into calcite after being in contact with water or ARS solution for 24 h and then being air-dried. Thus, the high ARS removal could be due to CaO produced after Cal being heated. The findings from this research proved that there is great potential in the use of calcite, a low-cost and readily available Earth material, after heat treatment for the removal of contaminants from water. Full article

Every year, new compounds contained in consumer products, such as detergents, paints, products for personal hygiene, and drugs for human and veterinary use, are identified in wastewater and are added to the list of molecules that need monitoring. These compounds are indicated with the term emerging contaminants (or Contaminants of Emerging Concern, CECs) since they are potentially dangerous for the environment and human health. To date, among the most widely used methodologies for the removal of CECs from the aquatic environment, adsorption processes play a role of primary importance, as they have proven to be characterized by high removal efficiency, low operating and management costs, and an absence of undesirable by-products. In this paper, the adsorption of ibuprofen (IBU), a nonsteroidal anti-inflammatory drug widely used for treating inflammation or pain, was performed for the first time using two different types of geopolymer-based materials, i.e., a metakaolin-based (GMK) and an organic–inorganic hybrid (GMK-S) geopolymer. The proposed adsorbing matrices are characterized by a low environmental footprint and have been easily obtained as powders or as highly porous filters by direct foaming operated directly into the adsorption column. Preliminary results demonstrated that these materials can be effectively used for the removal of ibuprofen from contaminated water (showing a concentration decrease of IBU up to about 29% in batch, while an IBU removal percentage of about 90% has been reached in continuous), thus suggesting their potential practical application. Full article

The Notch pathway is a key cancer driver and is important in tumor progression. Early research suggested that Notch activity was highly dependent on the expression of the intracellular cleaved domain of Notch-1 (NICD). However, recent insights into Notch signaling reveal the presence of Notch pathway signatures, which may vary depending on different cancer types and tumor microenvironments. Herein, we perform a comprehensive investigation of the Notch signaling pathway in adult T-cell leukemia (ATL) primary patient samples. Using gene arrays, we demonstrate that the Notch pathway is constitutively activated in ATL patient samples. Furthermore, the activation of Notch in ATL cells remains elevated irrespective of the presence of activating mutations in Notch itself or its repressor, FBXW7, and that ATL cells are dependent upon Notch-1 expression for proliferation and survival. We demonstrate that ATL cells exhibit the expression of pivotal Notch-related genes, including notch-1, hes1, c-myc, H19, and hes4, thereby defining a critical Notch signature associated with ATL disease. Finally, we demonstrate that lncRNA H19 is highly expressed in ATL patient samples and ATL cells and contributes to Notch signaling activation. Collectively, our results shed further light on the Notch pathway in ATL leukemia and reveal new therapeutic approaches to inhibit Notch activation in ATL cells. Full article

Breastfeeding is the most appropriate source of a newborn’s nutrition; among the plethora of its benefits, its modulation of circadian rhythmicity with melatonin as a potential neuroendocrine transducer has gained increasing interest. Transplacental transfer assures melatonin provision for the fetus, who is devoid of melatonin secretion. Even after birth, the neonatal pineal gland is not able to produce melatonin rhythmically for several months (with an even more prolonged deficiency following preterm birth). In this context, human breast milk constitutes the main natural source of melatonin: diurnal dynamic changes, an acrophase early after midnight, and changes in melatonin concentrations according to gestational age and during the different stages of lactation have been reported. Understudied thus far are the factors impacting on (changes in) melatonin content in human breast milk and their clinical significance in chronobiological adherence in the neonate: maternal as well as environmental aspects have to be investigated in more detail to guide nursing mothers in optimal feeding schedules which probably means a synchronized instead of mistimed feeding practice. This review aims to be thought-provoking regarding the critical role of melatonin in chrononutrition during breastfeeding, highlighting its potential in circadian entrainment and therefore optimizing (neuro)developmental outcomes in the neonatal setting. Full article