The present study involves the precise identification and safety evaluation of Enterococcus casseliflavus KB1733, previously identified using 16S rRNA analysis, through whole-genome sequencing, phenotypic analysis, and preclinical toxicity studies. Analyses based on the genome sequencing data confirm the identity of KB1733 as E. casseliflavus and show that the genes related to vancomycin resistance are only present on the chromosome, while no virulence factor genes are present on the chromosome or plasmid. Phenotypic analyses of antibiotic resistance and hemolytic activity also indicated no safety concerns. A bacterial reverse mutation test showed there was no increase in revertant colonies of heat-killed KB1733. An acute toxicity test employing heat-killed KB1733 at a dose of 2000 mg/kg body weight in rats resulted in no deaths and no weight gain or other abnormalities in the general condition of the animals, with renal depression foci and renal cysts only occurring at the same frequency as in the control. Taking the background data into consideration, the effects on the kidneys observed in the current study were not caused by KB1733. Our findings suggest that KB1733 is non-pathogenic to humans/animals, although further studies involving repeated oral toxicity tests and/or clinical tests are required. Full article

In Indonesia, plastic constitutes the second largest component of municipal solid waste; however, 58% remains uncollected. Most plastic recycling depends on informal sectors, accounting for only 10% of the total, leaving the remainder to potentially harm the environment. This paper analyzes how cities in Indonesia have tackled their plastic waste problems from the perspective of the integrated sustainable waste management framework. This study focuses on plastic waste management (PWM) in three cities: Bandung, Yogyakarta, and Magelang. Data were collected from 41 semi-structured interviews, a plastic waste composition data analysis, and site visits. The research outcomes include a comprehensive analysis of stakeholder roles, plastic waste flow, plastic waste composition data, and various challenges in PWM. This study identifies three main stakeholders in collecting plastic wastes: the Department of Environment as the main local government body, community-based waste banks, and private waste management companies. Most recyclable plastic waste is recovered through waste banks and private collection services. In 2022, the predominant types of plastic waste in Bandung, Yogyakarta, and Magelang City were soft plastics, thick plastics, and hard plastics, respectively. The challenges for the PWM stem from various aspects in political, legal, and institutional; environmental; financial and technical; and socio-cultural spheres. Positive trends towards an integrated system are observed, although full integration has not yet been achieved. The research recommends a multi-stakeholder cooperative approach involving municipal authorities, waste banks, and private collectors, responsive to local conditions and emphasizing sustainability aspects throughout waste management stages for a sustainable resource recycling in developing countries. Full article

Inflammatory bowel disease (IBD), a chronic inflammatory disease, results from dysregulation of the immune responses. The IBD prevalence rate was 321.2 per 100,000 people in 2021 and, compared with that in 2006 (200 per 100,000 people), had increased at a rate of +46%. Therefore, the development of a safe and new treatment for IBD is urgently needed. Weissella koreensis, a strain of lactic acid bacteria (LABs), was isolated from kimchi and shown to inhibit a pro-inflammatory cytokine, tumor necrosis factor-alpha (TNF-α). Its anti-inflammatory effect was further assessed using a mouse model of colitis induced by 2,4,6-trinitrobenzenesulfonic acid (TNBS). The administration of TNBS significantly increased myeloperoxidase (MPO) expression, macroscopic score, and colonic shortening. Oral administration of W. koreensis KJ suppressed the TNBS-induced response and significantly inhibited the expression of the pro-inflammatory cytokines TNF-α, interleukin (IL)-1β, and IL-6 in the intestinal tissues. In particular, W. koreensis KJ reversed the TNBS-induced decrease in the expression of these tight junction proteins. Therefore, since W. koreensis KJ isolated from kimchi, which increases gut tight junction proteins, attenuating colitis by suppressing inflammatory cytokines, it can be used as a therapeutic candidate for treating colitis such as IBD. Full article

The importance of digital tools for dietary assessment has increased in recent years, both commercially and scientifically. In the field of nutrition research, the digitization of dietary assessment methods presents many opportunities and risks. One of the main challenges is ensuring scientific quality while maintaining good usability. In this context, an evaluation tool was developed based on the guidelines of the European Food Safety Authorization (EFSA; 2009 and 2014), complemented by the usability aspect of health-related applications. This was followed by a literature search concerning the available dietary assessment tools, which were analyzed according to the evaluation criteria. Eight applications were included in the study after reviewing the inclusion and exclusion criteria for the digital tools. A total of thirty-eight requirements in eight main categories were defined for the evaluation, which the best possible dietary assessment tool should meet. The evaluation showed that none of the tested tools currently meet all the defined requirements or categories. The aspects of usability and the accuracy of data collection showed a positive correlation, suggesting a direct link between the two categories and providing an important approach for future developments. Full article

In this study, we systematically explored how changing groove surfaces of iron oxide/water nanofluid could affect the pool boiling heat transfer. We aimed to investigate the effect of three types of grooves, namely rectangular, circular, and triangular, on the boiling heat transfer. The goal was to improve heat transfer performance by consciously changing surface structure. Comparative analyses were conducted with deionized water to provide valuable insights. Notably, the heat transfer coefficient (HTC) exhibited a significant increase in the presence of grooves. For deionized water, the HTC rose by 91.7% and 48.7% on circular and rectangular grooved surfaces, respectively. Surprisingly, the triangular-grooved surface showed a decrease of 32.9% in HTC compared to the flat surface. On the other hand, the performance of the nanofluid displayed intriguing trends. The HTC for the nanofluid diminished by 89.2% and 22.3% on rectangular and triangular grooved surfaces, while the circular-grooved surface exhibited a notable 41.2% increase in HTC. These results underscore the complex interplay between groove geometry, fluid properties, and heat transfer enhancement in nanofluid-based boiling. Hence, we thoroughly examine the underlying mechanisms and elements influencing these observed patterns in this research. The results provide important insights for further developments in this area by shedding light on how surface changes and groove geometry may greatly affect heat transfer in nanofluid-based pool boiling systems. Full article

Background and Objectives: Connexin 43 (Cx43) is involved in the transfer of small signaling molecules between neighboring cells, thereby exerting a major influence on the initiation and progression of tumorigenesis. However, there is a lack of systematic research on Cx43 expression and its predictive role in clinical diagnosis and prognosis in pan-cancer. Materials and Methods: Several biological databases were used to evaluate the expression levels of GJA1 (encoding Cx43) and its diagnostic and prognostic significance in pan-cancer. We targeted kidney renal clear cell carcinoma (KIRC) and investigated the relationship between GJA1 expression and different clinical features of KIRC patients. Then, we performed cell-based experiments to partially confirm our results and predicted several proteins that were functionally related to Cx43. Results: The expression of GJA1 has a high level of accuracy in predicting KIRC. High GJA1 expression was remarkably correlated with a favorable prognosis, and this expression was reduced in groups with poor clinical features in KIRC. Cell experiments confirmed the inhibitory effects of increased GJA1 expression on the migratory capacity of human renal cancer (RCC) cell lines, and protein–protein interaction (PPI) analysis predicted that CDH1 and CTNNB1 were closely related to Cx43. Conclusions: GJA1 could be a promising independent favorable prognostic factor for KIRC, and upregulation of GJA1 expression could inhibit the migratory capacity of renal cancer cells. Full article

Losses from flood disasters are increasing globally due to climate-driven forces and human factors such as migration and land use changes. The risks of such floods involve multiple factors and stakeholders, and frameworks for integrated approaches have attracted a global community of experts. The paper reviews the knowledge base for integrated flood risk management frameworks, including more than twenty bibliometric reviews of their elements. The knowledge base illustrates how integrated strategies for the reduction of flood risk are required at different scales and involve responses ranging from climate and weather studies to the construction of infrastructure, as well as collective action for community resilience. The Integrated Flood Management framework of the Associated Programme on Flood Management of the World Meteorological Organization was developed more than twenty years ago and is explained in some detail, including how it fits within the Integrated Water Resources Management concept that is managed by the Global Water Partnership. The paper reviews the alignment of the two approaches and how they can be used in tandem to reduce flood losses. Success of both integrated management approaches depends on governance and institutional capacity as well as technological advances. The knowledge base for flood risk management indicates how technologies are advancing, while more attention must be paid to social and environmental concerns, as well as government measures to increase participation, awareness, and preparedness. Ultimately, integrated flood management will involve solutions tailored for individual situations, and implementation may be slow, such that perseverance and political commitment will be needed. Full article

The eastern region of the Huang-Huai area is vital for China’s coal production, with high water table mining causing significant surface subsidence and the formation of interconnected coal mining subsidence wetlands. Restoring these wetlands is crucial for biodiversity, environmental quality, and sustainable development. Aquatic vegetation plays a crucial role in wetland ecosystems, underscoring its importance in restoration efforts. Understanding and managing water level fluctuations is essential due to their impact on vegetation. This study examines the Qianshiliying coal mining subsidence wetland in the Yanzhou Mining Area, China, with the goal of devising a water level regulation plan based on the minimum ecological water level to improve the growth and recovery of aquatic vegetation. The research delves into landscape ecological restoration techniques for aquatic vegetation in coal mining subsidence wetlands in the eastern Huang-Huai region, emphasizing the importance of water level management. The results reveal that the minimum ecological water level in the Qianshiliying coal mining subsidence wetland is 32.50 m, and an area of 78.09 hectares is suitable for the reconstruction of aquatic vegetation. This paper utilizes lake morphology, minimum biological space, and water level demand methods for aquatic plants in the landscape to promote restoration of coal mining subsidence wetlands. A notable strength of this approach is its ability to quantitatively predict the survival range and area of aquatic vegetation in these wetlands, enabling a more scientifically informed restoration of ecological balance and promoting landscape ecological restoration in the eastern Huang-Huai region. Full article

As the prime candidate for plasma-facing materials (PFM), the response of tungsten (W) to thermal shock loads is an important research topic for future fusion devices. Under heat loads, the surface of tungsten plasma-facing materials (W-PFM) can experience thermal damage, including brittle cracking and fatigue cracks. Therefore, exploring solutions for thermal damage of W-PFM remains one of the current research focuses. We propose a novel approach to mitigate thermal radiation damage in PFM, namely, the stacked structure W-PFM. The surface thermal stress distribution of the stacked structure W-PFM under heat loads was simulated and analyzed by the finite element method. As the foil thickness decreases, both the peak thermal stresses in the normal direction (ND) and rolling direction (RD) decrease. When the thickness decreases to a certain value, the peak thermal stress in the RD decreases to about 1384 MPa and no longer decreases; while the peak thermal stress in the ND approaches 0 MPa and can be neglected. In the range of approximately 5–100 mm, the accumulated equivalent plastic strain decreases sharply as the thickness decreases; in other thickness ranges, it decreases slowly. Thermal fatigue experiments were conducted on the stacked structure W composed of W foils with different thicknesses and bulk W using an electron beam facility. The samples were applied with a power density of 30 MW/m² for 10,000 and 20,000 pulses. The cracks on the surface of the stacked structure W extended along the ND direction, while on the surface of bulk W, besides the main crack in the ND direction, a crack network also formed. The experimental results were consistent with finite element simulations. When the pulse number was 10,000, as the thickness of the W foil decreased, the number and width of the cracks on the surface of the stacked structure W decreased. Only four small cracks were present on the surface of stacked structure W (0.05 mm). When the pulse number increased to 20,000, the plastic deformation and number of cracks on the surface of all samples increased. However, the stacked structure W (0.05 mm) only added one small crack and had the smallest surface roughness (Ra = 1.536 μm). Quantitative analysis of the fatigue cracks showed that the stacked structure W-PFM (0.05 mm) exhibited superior thermal fatigue performance. Full article

MXenes are a family of two-dimensional nanomaterials. Titanium carbide MXene (Ti₃C₂T_x-MXene), reported in 2011, is the first inorganic compound reported among the MXene family. In the present work, we report on the study of the composition and various physical properties of Ti₃C₂T_x-MXene nanomaterial, as well as their temperature evolution, to consider MXenes for space applications. X-ray diffraction, thermal analysis and mass spectroscopy measurements confirmed the structure and terminating groups of the MXene surface, revealing a predominant single OH layer character. The temperature dependence of the specific heat shows a Debye-like character in the measured range of 2 K–300 K with a linear part below 10 K, characteristic of conduction electrons of metallic materials. The electron density of states (DOS) calculations for Ti₃C₂OH-MXene reveal a significant DOS value at the Fermi level, with a large slope, confirming its metallic character, which is consistent with the experimental findings. The temperature dependence of electrical resistivity of the MXene samples was tested for a wide temperature range (3 K–350 K) and shows a decrease on lowering temperature with an upturn at low temperatures, where negative magnetoresistance is observed. The magnetoresistance versus field is approximately linear and increases its magnitude with decreasing temperature. The magnetization curves are straight lines with temperature-independent positive slopes, indicating Pauli paramagnetism due to conduction electrons. Full article

The S-transform is a fundamental time–frequency (T-F) domain analysis method in ground penetrating radar (GPR) data processing and can be used for identifying targets, denoising, extracting thin layers, and high-resolution imaging. However, the S-transform spectrum experiences energy leakage near the instantaneous frequency. This phenomenon causes frequency components to erroneously spread over a wider range, impacting the accuracy and precision of GPR data processing. Synchrosqueezing is an effective method to prevent spectrum leakage. In this work, we introduce the synchrosqueezing generalized phase-shifting S-transform (SS-GPST). Initially, it resolves the compatibility issue between the S-transform and the synchrosqueezing strategy through phase-shifting. Subsequently, the SS-GPST accomplishes spectral energy focusing and resolution enhancement via a generalized parameter and synchrosqueezing. A synthetic signal test shows that the SS-GPST excels over other methods at focusing degree, spectral resolution, and signal reconstruction accuracy and speed. In actual GPR tunnel detection data processing, we assess the adaptability of the SS-GPST from three aspects: spectral energy distribution, thin layer identification, and data denoising. The results indicate: (1) compared to other methods, the SS-GPST accurately expresses spectral components with a strong focusing degree and fewer interference components; (2) high-frequency slices of the SS-GPST accurately detect the top and bottom interfaces of a 3.0–3.5 cm reinforcement protection layer; and (3) due to fewer interference components in the SS-GPST spectrum, reconstructing GPR profiles through the SS-GPST inverse transform is an efficient denoising technique. The SS-GPST demonstrates adaptability to different data processing purposes, offers high-resolution T-F spectra, and shows potential to supersede the S-transform. Full article

Magnetic nanofluids, also referred to as ferromagnetic particle levitation systems, are materials with highly responsive magnetic properties. Due to their magnetic responsiveness, excellent controllability, favorable thermal characteristics, and versatility, magnetic nanofluids have sparked considerable interest in both industrial manufacturing and scientific research. Magnetic nanofluids have been used and developed in diverse areas such as materials science, physics, chemistry and engineering due to their remarkable characteristics such as rapid magnetic reaction, elastic flow capacities, and tunable thermal and optical properties. This paper provides a full and in-depth introduction to the diverse uses of ferrofluids including material fabrication, fluid droplet manipulation, and biomedicine for the power and machinery sectors. As a result, magnetic nanofluids have shown promising applications and have provided innovative ideas for multidisciplinary research in biology, chemistry, physics and materials science. This paper also presents an overview of the device construction and the latest developments in magnetic-nanofluid-related equipment, as well as possible challenging issues and promising future scenarios. Full article

To model fuzzy numbers with the confidence degree and better account for information uncertainty, Zadeh came up with the notion of Z-numbers, which can effectively combine the objective information of things with subjective human interpretation of perceptive information, thereby improving the human comprehension of natural language. Although many numbers are in fact Z-numbers, their higher computational complexity often prevents their recognition as such. In order to reduce computational complexity, this paper reviews the development and research direction of Z-numbers and deduces the operational rules for symmetric triangular Z-numbers. We first transform them into classical fuzzy numbers. Using linear programming, the extension principle of Zadeh, the convolution formula, and fuzzy number algorithms, we determine the operational rules for the basic operations of symmetric triangular Z-numbers, which are number-multiplication, addition, subtraction, multiplication, power, and division. Our operational rules reduce the complexity of calculation, improve computational efficiency, and effectively reduce the information difference while being applicable to other complex operations. This paper innovatively combines Z-numbers with classical fuzzy numbers in Z-number operations, and as such represents a continuation and innovation of the research on the operational laws of Z-numbers. Full article

In recent years, clustered regularly interspaced short palindromic repeats (CRISPRs) and CRISPR-associated (Cas) protein have emerged as a revolutionary gene editing tool to treat inherited disorders affecting different organ systems, such as blood and muscles. Both hematological and neuromuscular genetic disorders benefit from genome editing approaches but face different challenges in their clinical translation. The ability of CRISPR/Cas9 technologies to modify hematopoietic stem cells ex vivo has greatly accelerated the development of genetic therapies for blood disorders. In the last decade, many clinical trials were initiated and are now delivering encouraging results. The recent FDA approval of Casgevy, the first CRISPR/Cas9-based drug for severe sickle cell disease and transfusion-dependent β-thalassemia, represents a significant milestone in the field and highlights the great potential of this technology. Similar preclinical efforts are currently expanding CRISPR therapies to other hematologic disorders such as primary immunodeficiencies. In the neuromuscular field, the versatility of CRISPR/Cas9 has been instrumental for the generation of new cellular and animal models of Duchenne muscular dystrophy (DMD), offering innovative platforms to speed up preclinical development of therapeutic solutions. Several corrective interventions have been proposed to genetically restore dystrophin production using the CRISPR toolbox and have demonstrated promising results in different DMD animal models. Although these advances represent a significant step forward to the clinical translation of CRISPR/Cas9 therapies to DMD, there are still many hurdles to overcome, such as in vivo delivery methods associated with high viral vector doses, together with safety and immunological concerns. Collectively, the results obtained in the hematological and neuromuscular fields emphasize the transformative impact of CRISPR/Cas9 for patients affected by these debilitating conditions. As each field suffers from different and specific challenges, the clinical translation of CRISPR therapies may progress differentially depending on the genetic disorder. Ongoing investigations and clinical trials will address risks and limitations of these therapies, including long-term efficacy, potential genotoxicity, and adverse immune reactions. This review provides insights into the diverse applications of CRISPR-based technologies in both preclinical and clinical settings for monogenic blood disorders and muscular dystrophy and compare advances in both fields while highlighting current trends, difficulties, and challenges to overcome. Full article

Wave-induced seabed liquefaction significantly jeopardizes the stability of marine structures and the safety of human life. Susceptibility assessment is key to enabling spatial predictions and establishing a solid foundation for effective risk analysis and management. However, the current research encounters various challenges, involving an incomplete evaluation system, poor applicability of methods, and insufficient databases. These issues collectively hinder the accuracy of susceptibility assessments, undermining their utility in engineering projects. To address these challenges, a susceptibility assessment method with the safety factor was developed as the key assessment parameter, allowing for a comprehensive susceptibility assessment across the silt-dominated nearshore environment using Empirical Bayesian Kriging (EBK). The safety factor is determined by combining the cyclic stress ratio (CSR) and the cyclic resistance ratio (CRR), which characterize wave loadings and sediment properties in the study area, respectively. This method was applied in the Chengdao region of the Yellow River Estuary, China, a typical silt-dominated nearshore environment where wave-induced liquefaction events have been reported as being responsible for multiple oil platform and pipeline accidents. By collecting the regional wave and seabed sediment data from cores spanning from 1998 to 2017, the safety factors were calculated, and a zonal map depicting the susceptibility assessment of wave-induced seabed liquefaction was created. This study can serve as a valuable reference for the construction and maintenance of marine engineering in liquefaction-prone areas. Full article

Diabetic foot ulcers (DFUs) significantly affect the lives of patients and increase the risk of hospital stays and amputation. We suggest a remote monitoring platform for better DFU care. This system uses digital health metrics (scaled from 0 to 10, where higher scores indicate a greater risk of slow healing) to provide a comprehensive overview through a visual interface. The platform features smart offloading devices that capture behavioral metrics such as offloading adherence, daily steps, and cadence. Coupled with remotely measurable frailty and phenotypic metrics, it offers an in-depth patient profile. Additional demographic data, characteristics of the wound, and clinical parameters, such as cognitive function, were integrated, contributing to a comprehensive risk factor profile. We evaluated the feasibility of this platform with 124 DFU patients over 12 weeks; 39% experienced unfavorable outcomes such as dropout, adverse events, or non-healing. Digital biomarkers were benchmarked (0–10); categorized as low, medium, and high risk for unfavorable outcomes; and visually represented using color-coded radar plots. The initial results of the case reports illustrate the value of this holistic visualization to pinpoint the underlying risk factors for unfavorable outcomes, including a high number of steps, poor adherence, and cognitive impairment. Although future studies are needed to validate the effectiveness of this visualization in personalizing care and improving wound outcomes, early results in identifying risk factors for unfavorable outcomes are promising. Full article

Epidemiological studies have shown that a diet rich in bioactive components significantly reduces cardiovascular disease incidence and mortality. In this sense, there is a need for meta-analytical research that confirms this phenomenon and increases specific knowledge about certain bioactive compounds such as carotenoids. Thus, this systematic review and meta-analysis aim to disseminate knowledge about the sources of carotenoids in fruit consumed in the north of Brazil which are outside the Brazilian trade balance. A systematic review and a meta-analysis following the PRISMA guidelines were conducted based on a random effects synthesis of multivariable-adjusted relative risks (RRs). Searches of seven sources were carried out, including PubMed, Science Direct from Elsevier, Web of Science, Scielo, Eric Research and Google Scholar databases. The systematic review was guided by a systematic review protocol based on the POT strategy (population, outcome and type of study) adapted for use in this research. Mendeley was a resource used to organize and manage references and exclude duplicates of studies selected for review. In this review, we present the potential bioactive compounds concentrated in little-known fruit species from the Amazon and their benefits. Consuming fruits that are rich in notable constituents such as carotenoids is important for the prevention of chronic non-communicable diseases through anti-inflammatory and anticoagulant properties, as well as antivirals, immunomodulators and antioxidants agents that directly affect the immune response. Full article

Pancreatic cancer (PC) has a poor prognosis and displays resistance to immunotherapy. A better understanding of tumor-derived extracellular vesicle (EV) effects on immune responses might contribute to improved immunotherapy. EVs derived from Capan-2 and BxPC-3 PC cells isolated by ultracentrifugation were characterized by atomic force microscopy, Western blot (WB), nanoparticle tracking analysis, and label-free proteomics. Fresh PBMCs from healthy donors were treated with PC- or control-derived heterologous EVs, followed by flow cytometry analysis of CD8+ and CD4+ lymphocytes. The proteomics of lymphocytes sorted from EV-treated or untreated PBMCs was performed, and the IFN-γ concentration was measured by ELISA. Notably, most of the proteins identified in Capan-2 and BxPC-3 EVs by the proteomic analysis were connected in a single functional network (p = 1 × 10⁻¹⁶) and were involved in the “Immune System” (FDR: 1.10 × 10⁻²⁴ and 3.69 × 10⁻¹⁹, respectively). Interestingly, the treatment of healthy donor-derived PBMCs with Capan-2 EVs but not with BxPC-3 EVs or heterologous control EVs induced early activation of CD8+ and CD4+ lymphocytes. The proteomics of lymphocytes sorted from EV-treated PBMCs was consistent with their activation by Capan-2 EVs, indicating IFN-γ among the major upstream regulators, as confirmed by ELISA. The proteomic and functional analyses indicate that PC-EVs have pleiotropic effects, and some may activate early immune responses, which might be relevant for the development of highly needed immunotherapeutic strategies in this immune-cold tumor. Full article

wetA, one of the conidiation center regulatory genes in many filamentous fungi, plays an important role in promoting asexual spores (conidia) maturation. Our recent research has found that knocking out or overexpressing MrwetA (a homolog of wetA) in Monascus ruber M7 does not affect the development of its asexual spores like other fungi, but both repress the development of its sexual spores (ascospores). However, the mechanism remains unclear. In this study, the function of MrwetA on sexual reproduction and secondary metabolism in M. ruber M7 was confirmed by a complementary experiment. Moreover, the regulatory roles of MrwetA in modulating the expression of genes involved in sexual reproduction, meiosis, and biosynthesis of Monascus pigment and citrinin were analyzed based on the transcriptional data. These results not only contribute to clarifying the regulation of the reproduction and secondary metabolism of Monascus spp., but also to enriching the regulation molecular mechanism of reproduction in filamentous fungi. Full article

This paper studies the problem of minimizing the total cost, including computation cost and communication cost, in the system of two-sided secure distributed matrix multiplication (SDMM) under an arbitrary collusion pattern. In order to perform SDMM, the two input matrices are split into some blocks, blocks of random matrices are appended to protect the security of the two input matrices, and encoded copies of the blocks are distributed to all computing nodes for matrix multiplication calculation. Our aim is to minimize the total cost, overall matrix splitting factors, number of appended random matrices, and distribution vector, while satisfying the security constraint of the two input matrices, the decodability constraint of the desired result of the multiplication, the storage capacity of the computing nodes, and the delay constraint. First, a strategy of appending zeros to the input matrices is proposed to overcome the divisibility problem of matrix splitting. Next, the optimization problem is divided into two subproblems with the aid of alternating optimization (AO), where a feasible solution can be obtained. In addition, some necessary conditions for the problem to be feasible are provided. Simulation results demonstrate the superiority of our proposed scheme compared to the scheme without appending zeros and the scheme with no alternating optimization. Full article

In the UAV swarm, the degradation in the health status of some UAVs often brings negative effects to the system. To compensate for the negative effect, we present a fault-tolerant Multi-Agent Reinforcement Learning Algorithm that can control an unstable Multiple Unmanned Aerial Vehicle (Multi-UAV) system to perform exploration tasks. Different from traditional multi-agent methods that require the agents to remain healthy during task execution, our approach breaks this limitation and allows the agents to change status during the task. In our algorithm, the agent can accept both the adjacency state matrix about the neighboring agents and a kind of healthy status vector to integrate both and generate the communication topology. During this process, the agents with poor health status are given more attention for returning to normal status. In addition, we integrate a temporal convolution module into our algorithm and enable the agent to capture the temporal information during the task. We introduce a scenario regarding Multi-UAV ground exploration, where the health status of UAVs gradually weakens over time before dropping into a fault status; the UAVs require rescues from time to time. We conduct some experiments in this scenario and verify our algorithm. Our algorithm can increase the drone’s survival rate and make the swarm perform better. Full article