Atherosclerosis is a complex condition that involves the accumulation of lipids and subsequent plaque formation in the arterial intima. There are various stimuli, cellular receptors, and pathways involved in this process, but oxidative modifications of low-density lipoprotein (ox-LDL) are particularly important in the onset and progression of atherosclerosis. Ox-LDLs promote foam-cell formation, activate proinflammatory pathways, and induce smooth-muscle-cell migration, apoptosis, and cell death. One of the major receptors for ox-LDL is LOX-1, which is upregulated in several cardiovascular diseases, including atherosclerosis. LOX-1 activation in endothelial cells promotes endothelial dysfunction and induces pro-atherogenic signaling, leading to plaque formation. The binding of ox-LDLs to LOX-1 increases the generation of reactive oxygen species (ROS), which can induce LOX-1 expression and oxidize LDLs, contributing to ox-LDL generation and further upregulating LOX-1 expression. This creates a vicious circle that is amplified in pathological conditions characterized by high plasma levels of LDLs. Although LOX-1 has harmful effects, the clinical significance of inhibiting this protein remains unclear. Further studies both in vitro and in vivo are needed to determine whether LOX-1 inhibition could be a potential therapeutic target to counteract the atherosclerotic process. Full article

To deal with the challenges posed by generational differences in China’s sustainable consumption transition, this study’s pioneers using a mixed-methods approach with data mining and literature research to classify Chinese residents into four generations based on the sustainable consumption perspective. We developed a conceptual model of generational differences and conducted an empirical study using structured interviews with a multi-stage random sampling approach. The results highlight significant differences and distinct influencing mechanisms among the four generations regarding perceptions of sustainable consumption, lifestyle, and sustainable consumption behavior. Based on this, multi-generational differentiated green marketing strategies, green product development and green marketing practices, as well as consumer education systems and strategies for stakeholders including the government, enterprises, and society are proposed. The findings contribute to advancing theoretical perspectives in sustainable consumption research, serving as a valuable reference for sustainable consumption research worldwide. Full article

Juvenile myasthenia gravis (MG) is a rare autoimmune neuromuscular disease, often treated with anticholinesterases, corticosteroids, and immunosuppressants. However, optimal treatment durations remain unclear. This study investigated the clinical characteristics and treatment of juvenile MG, including medication duration. The administration period for all drugs, immunosuppressants, and prednisolone at doses greater than 0.35 mg/kg daily was extracted retrospectively from medical records. Nineteen participants (8 boys, 11 girls) aged 8 months to 14 years (median, 2.5 years) at onset were identified. Fourteen patients (73.7%) had ocular MG and five (26.3%) had generalized MG. Drug treatment was conducted in 18 cases; however, 7 patients did not complete the treatment. Among the patients who completed drug treatment, the duration of treatment ranged from 11 to 100 months (median, 47 months). In the six patients treated with continuous administration of prednisolone or immunosuppressants, the treatment duration ranged from 33 to 99 months (median, 56 months). No severe adverse effects requiring hospitalization were reported. The patients treated with prednisolone or immunosuppressants required at least 33 months of treatment. These results will help develop protocols for juvenile MG treatment. Full article

Energy management strategies play a crucial role in enhancing the fuel efficiency of hybrid electric vehicles (HEVs) and mitigating greenhouse gas emissions. For the current commonly used time horizon optimization methods that only target the trend curve of the optimal battery state of charge (SOC) trajectory obtained offline, which are only suitable for buses with known future driving conditions, this paper proposed an energy management strategy based on an adaptive network-based fuzzy inference system (ANFIS) that optimizes the time horizon length and enhances adaptability to driving conditions by integrating historical vehicle velocity, accelerations, and battery SOC trajectory. First, the vehicle velocity prediction model based on the radial basis function (RBF) neural network is used to predict the future velocity sequence. After that, ANFIS was used to optimize and update the length of the forecast time horizon based on the historical vehicle velocity sequence. Finally, compared with the fixed time horizon energy management strategy, which is based on model predictive control (MPC), the average calculation time of the energy management strategy is reduced by about 23.5%, and the fuel consumption per 100 km is reduced by about 6.12%. Full article

An interleaved high voltage gain DC-DC converter with winding-cross-coupled inductors (WCCIs) and voltage multiplier cells is proposed for photovoltaic systems. The converter configuration is based on the interleaved boost converter integrating the diode-capacitor clamp circuits, the winding-cross-coupled inductors, and voltage multiplier cells to increase the voltage gain and reduce the semiconductor voltage stresses. The equal current sharing of two phases is achieved with the help of the winding-cross-coupled inductors. The converter achieves high voltage gain while operating at a proper duty ratio. The low-voltage-rated MOSFETs with low on-resistance are available to reduce the conduction losses due to the low switch voltage stress. The leakage energy of the coupled inductors is recycled such that the voltage spikes on the power switches are avoided. The input current ripple is decreased due to the interleaved operation. The operating principle and steady-state analysis of the proposed converter are proposed in detail. The design guidelines of the proposed converter are given. In addition, the closed-loop controlled system of the proposed converter is designed to diminish the effect of the variations in input voltage and load on the output voltage. Finally, the experimental results of a 1000 W converter prototype with 36 V input and 400 V output are given to validate the theoretical analysis and the converter performance. Full article

This study proposes an anti-gravity 3D pulsating heat pipe (PHP) for cooling pouch batteries in electric vehicles. The 3D PHP envelops the battery cells and rapidly transfers heat generated from the batteries to the bottom cold plate. While the batteries generate heat on their frontal surface during charging and discharging, structural characteristics lead to localized heat accumulation at the electrode lead tabs. Therefore, to address frontal heating, Pattern A with a consistent height for the 3D PHP and Pattern B with varying heights to enhance heat transfer in the localized heating area were designed. The target application involved creating a battery simulator for 340 × 100 mm pouch battery cells, considering the battery’s heat generation characteristics. The experiments for the thermal characteristics were conducted, considering factors such as the working fluid (methanol, Novec7100), filling ratio, supplied heat, and orientation. Additionally, to observe internal flow mechanisms, a special experimental apparatus was used, employing transparent fluorine rubber tubes to observe the flow mechanism of the 3D PHP. In the results of the thermal characteristics, the optimal filling ratio was 15% when heat generation levels of 50 W and 100 W were supplied and 20% when 150 W was supplied. The impact of orientation yielded varied results depending on the pattern and working fluid, attributed to the complex interplay of flow momentum due to orientation changes and the influence of the working fluid’s buoyancy under anti-gravity conditions. Pattern B, designed with the goal of applying a localized heat model, exhibited relatively decreased heat transfer performance in areas with varying heights. As the distance from the varying height portion increased, temperature oscillations and heat transfer became more active. These results suggest that variations in the shape of the 3D PHP could be a primary design variable for crafting localized heat models. Observations of internal flow revealed that the 3D PHP, with its unique shape and operation under anti-gravity conditions, exhibits longer and more irregular cycles compared to gravity-assist PHPs, transferring heat through rapid oscillations of internal working fluid liquid/vapor slug/plug. The potential of 3D PHPs for cooling electric vehicle batteries is suggested by these findings, and further experimentation is planned to evaluate the optimal design and applicability. Full article

Chronic obstructive pulmonary disease (COPD) is a progressive lung disease that is commonly considered to be a potent driver of non-small cell lung cancer (NSCLC) development and related mortality. A growing body of evidence supports a role of the immune system, mainly played by alveolar macrophages (AMs), in key axes regulating the development of COPD or NSCLC phenotypes in response to harmful agents. MicroRNAs (miRNAs) are small non-coding RNAs that influence most biological processes and interfere with several regulatory pathways. The purpose of this study was to assess miRNA expression patterns in patients with COPD, NSCLC, and ever- or never-smoker controls to explore their involvement in smoking-related diseases. Bronchoalveolar lavage (BAL) specimens were collected from a prospective cohort of 43 sex-matched subjects to determine the expressions of hsa-miR-223-5p, 16-5p, 20a-5p, -17-5p, 34a-5p and 106a-5p by RT-PCR. In addition, a bioinformatic analysis of miRNA target genes linked to cancer was performed. Distinct and common miRNA expression levels were identified in each pathological group, suggesting their possible role as an index of NSCLC or COPD microenvironment. Moreover, we identified miRNA targets linked to carcinogenesis using in silico analysis. In conclusion, this study identified miRNA signatures in AMs, allowing us to understand the molecular mechanisms underlying smoking-related conditions and potentially providing new insights for diagnosis or pharmacological treatment. Full article

Autonomous robotic teams have been proposed for a variety of lost-person searches in wilderness and urban settings. In the latter scenarios, for missing persons, the application of such teams, however, is more challenging than it would be in the wilderness. This paper, specifically, examines the application of an autonomous team of unmanned aerial vehicles (UAVs) to perform a sparse, mobile-target search in an urban setting. A novel multi-UAV search-trajectory planning method, which relies on the prediction of the missing-person’s motion, given a known map of the search environment, is the primary focus. The proposed method incorporates periodic updates of the estimates of where the lost/missing person may be, allowing for intelligent re-coverage of previously searched areas. Additional significant contributions of this work include a behavior-based motion-prediction method for missing persons and a novel non-parametric estimator for iso-probability-based (missing-person-location) curves. Simulated experiments are presented to illustrate the effectiveness of the proposed search-planning method, demonstrating higher rates of missing-person detection and in shorter times compared to other methods. Full article

The influence of surface modification on the properties of bagasse fibers and asphalt binders/mixtures was investigated. Bagasse fibers were modified by single, binary, and ternary methods with hydrochloric acid, sodium hydroxide, and sodium chlorite, respectively. The physical and chemical properties of bagasse fibers were analyzed by scanning electron microscopy, Fourier transform infrared spectroscopy, and an adsorption test, respectively. The rheological properties of asphalt binders with bagasse fibers or lignin fibers were analyzed by the dynamic shear rheometer test and bending beam rheometer test. In addition, the performance of asphalt mixtures with bagasse fibers or lignin fibers were evaluated by a wheel rutting test, bending test at a low temperature, and water stability test, respectively. In conclusion, the hydrophilic functional groups on the fiber surface were partially eliminated by modification, facilitating the degradation of different fiber components. Furthermore, the degree of fibrillation was improved, and more interfaces with asphalt components were formed, thus enhancing the high-temperature deformation resistance of asphalt binders, but slightly impairing its low-temperature performance. Among all modification methods, the ternary composite modification exerted important influences on fiber structure, oil absorption, and rheological properties of asphalt binders, significantly enhancing the performance of asphalt mixtures. Combined with surface modification methods, bagasse fibers would be promising reinforced pavement materials. Full article

The only reliable factor that reduces the risk of colorectal carcinogenesis is physical activity. However, the underlying mechanisms remain unclear. In this study, we examined the effects of physical activity against gut microbiota, including mucosa-associated microbiota (MAM) on azoxymethane-induced colorectal tumors in obese mice. We divided the subjects into four groups: normal diet (ND), high-fat diet (HFD), ND + exercise (Ex), and HFD + Ex groups. The Ex group performed treadmill exercise for 20 weeks. Thereafter, fecal and colonic mucus samples were extracted for microbiota analysis. DNA was collected from feces and colonic mucosa, and V3–V4 amplicon sequencing analysis of the 16SrRNA gene was performed using MiSeq. The HFD group had significantly more colonic polyps than the ND group (ND 6.5 ± 1.3, HFD 11.4 ± 1.5, p < 0.001), and the addition of Ex suppressed the number of colonic polyps in ND and HFD groups (ND 6.5 ± 1.3, ND + Ex 2.8 ± 2.5, p < 0.05). The HFD group showed significantly lower concentrations of succinic, acetic, butyric, and propionic acids (mg/g) in feces, compared with the ND group (succinic acid HFD 0.59, ND 0.17; acetic acid HFD 0.63, ND 2.41; propionic acid HFD 0.10, ND 0.47; and N-butyric acid HFD 0.31, ND 0.93). In the case of ND, succinic acid and butyric acid tended to decrease with Ex (succinic acid ND 0.17, ND + Ex 0.12; N-butyric acid ND 0.93, ND + Ex 0.74 0.74). Succinic acid, acetic acid, butyric acid, and propionic acid levels in feces were significantly lower in the HFD group than in the ND group; in both feces and mucus samples, Butyricicoccus and Lactobacillus levels were significantly lower in the HFD group. Akkermansia was significantly increased in ND + Ex and HFD + Ex groups. Diet and exercise affected the number of colorectal tumors. Furthermore, diet and exercise alter intestinal MAM, which may be involved in colorectal tumor development. Full article

Artificial intelligence (AI) and blockchain technology have emerged as increasingly prevalent and influential elements shaping global trends in Information and Communications Technology (ICT). Namely, the synergistic combination of blockchain and AI introduces beneficial, unique features with the potential to enhance the performance and efficiency of existing ICT systems. However, presently, the confluence of these two disruptive technologies remains in a rather nascent stage, undergoing continuous exploration and study. In this context, the work at hand offers insight regarding the most significant features of the AI and blockchain intersection. Sixteen outstanding, recent articles exploring the combination of AI and blockchain technology have been systematically selected and thoroughly investigated. From them, fourteen key features have been extracted, including data security and privacy, data encryption, data sharing, decentralized intelligent systems, efficiency, automated decision systems, collective decision making, scalability, system security, transparency, sustainability, device cooperation, and mining hardware design. Moreover, drawing upon the related literature stemming from major digital databases, we constructed a timeline of this technological convergence comprising three eras: emerging, convergence, and application. For the convergence era, we categorized the pertinent features into three primary groups: data manipulation, potential applicability to legacy systems, and hardware issues. For the application era, we elaborate on the impact of this technology fusion from the perspective of five distinct focus areas, from Internet of Things applications and cybersecurity, to finance, energy, and smart cities. This multifaceted, but succinct analysis is instrumental in delineating the timeline of AI and blockchain convergence and pinpointing the unique characteristics inherent in their integration. The paper culminates by highlighting the prevailing challenges and unresolved questions in blockchain and AI-based systems, thereby charting potential avenues for future scholarly inquiry. Full article

The interplay patterns of amino acid residues are pivotal in determining the tertiary structure and flexibility of proteins, which in turn are intricately linked to their functionality and interactions with other molecules. Here, we introduce ARIP, a novel tool designed to identify contact residues within proteins. ARIP employs a modified version of the dr_sasa algorithm and an atomic overlap weighted algorithm to directly calculate the contact area and volume between atoms based on their van der Waals radius. It also allows for the selection of solvent radii, recognizing that not every atom in proteins can interact with water molecules. The solvent parameters were derived from the analysis of approximately 5000 protein and nucleic acid structures with water molecules determined using X-ray crystallography. One advantage of the modified algorithm is its capability to analyze multiple models within a single PDB file, making it suitable for molecular dynamic capture. The contact volume is symmetrically distributed between the interacting atoms, providing more informative results than contact area for the analysis of intra- and intermolecular interactions and the development of scoring functions. Furthermore, ARIP has been applied to four distinct cases: capturing key residue–residue contacts in NMR structures of P4HB, protein–drug binding of CYP17A1, protein–DNA binding of SPI1, and molecular dynamic simulations of BRD4. Full article

While there have been studies on the relationship between higher education institutions and regional economic growth, few have delved into the economic impact of decentralized higher education institutions at the county level and associated reginal disparities in terms of socio-economic development. Utilizing the data of the Chinese universities that started to establish their campuses in counties since the year 1999, this study investigates the influence of rural university campuses on county-level GDP and industrial composition spanning from 2001 to 2020. It also delves into the temporal dynamics and regional discrepancies associated with this impact. The findings of this study show that (a) rural university campuses wield a notable positive influence on the GDP of their respective counties, particularly shaping the structure and ratio of secondary and tertiary industries; (b) the magnitude of this effect is contingent upon the duration of campus establishment and growth, intensifying over time; (c) variations in this impact are evident across the eastern, central, and western regions of China, where there are vast socio-economic differences. This study underscores the significant spillover effect of higher education decentralization on county-level economies and advocates for the pivotal role of rural university campuses in propelling county-level economic progress. Additionally, it proposes coordinated policy support from national, regional, and rural university campus authorities; the establishment of requisite support structures; and the comprehensive consideration of regional nuances. Full article

This paper presents a new multiple-input single-output voltage-mode universal filter employing four multiple-input operational transconductance amplifiers (MI-OTAs) and three grounded capacitors suitable for low-voltage low-frequency applications. The quality factor (Q) of the filter functions can be tuned by both the capacitance ratio and the transconductance ratio. The multiple inputs of the OTA are realized using the bulk-driven multiple-input MOS transistor technique. The MI-OTA-based filter can also offer many filtering functions without additional circuitry requirements, such as an inverting amplifier to generate an inverted input signal. The proposed filter can simultaneously realize low-pass, high-pass, band-pass, band-stop, and all-pass responses, covering both non-inverting and inverting transfer functions in a single topology. The natural frequency and the quality factors of all the filtering functions can be controlled independently. The natural frequency can also be electronically controlled by tuning the transconductances of the OTAs. The proposed filter uses a 1 V supply voltage, consumes 120 μW of power for a 5 μA setting current, offers 40 dB of dynamic range and has a third intermodulation distortion of −43.6 dB. The performances of the proposed circuit were simulated using a 0.18 μm TSMC CMOS process in the Cadence Virtuoso System Design Platform to confirm the performance of the topology. Full article

The integration of heterostructures within electrode materials is pivotal for enhancing electron and Li-ion diffusion kinetics. In this study, we synthesized CoO/MnO heterostructures to enhance the electrochemical performance of MnO using a straightforward electrostatic spinning technique followed by a meticulously controlled carbonization process, which results in embedding heterostructured CoO/MnO nanoparticles within porous nitrogen-doped carbon nanofibers (CoO/MnO/NC). As confirmed by density functional theory calculations and experimental results, CoO/MnO heterostructures play a significant role in promoting Li⁺ ion and charge transfer, improving electronic conductivity, and reducing the adsorption energy. The accelerated electron and Li-ion diffusion kinetics, coupled with the porous nitrogen-doped carbon nanofiber structure, contribute to the exceptional electrochemical performance of the CoO/MnO/NC electrode. Specifically, the as-prepared CoO/MnO/NC exhibits a high reversible specific capacity of 936 mA h g⁻¹ at 0.1 A g⁻¹ after 200 cycles and an excellent high-rate capacity of 560 mA h g⁻¹ at 5 A g⁻¹, positioning it as a competitive anode material for lithium-ion batteries. This study underscores the critical role of electronic and Li-ion regulation facilitated by heterostructures, offering a promising pathway for designing transition metal oxide-based anode materials with high performances for lithium-ion batteries. Full article

Plants’ root properties are closely related to their ecological adaptability. This study aimed to clarify the differences in root properties of Stipa krylovii under different grazing disturbances. The morphological characteristics of root length, root surface area, root volume, root tip number, specific root length, and specific surface area of S. krylovii were compared under no grazing, light grazing, moderate grazing and heavy grazing conditions. The ecological adaptability to grazing pressure was also examined. Results showed that the underground biomass density decreased with the increase in grazing intensity. Grazing disturbance can lead to changes in plant community characteristics, and roots adapt to changes in these environmental factors by adjusting their distribution. Among the six root configuration parameters, those under light grazing were significantly higher than those under the other grazing types. The root length and root surface area were concentrated in the range of 0–2 mm. Mild grazing and moderate grazing were conducive to fine root penetration and contact with soil. Moderate grazing disturbance was beneficial to grassland vegetation productivity and played an important role in the stability and sustainable utilization of grassland ecosystem. Full article

The reprogramming of somatic cells to pluripotent stem cells has immense potential for use in regenerating or redeveloping tissues for transplantation, and the future application of this method is one of the most important research topics in regenerative medicine. These cells are generated from normal cells, adult stem cells, or neoplastic cancer cells. They express embryonic stem cell markers, such as OCT4, SOX2, and NANOG, and can differentiate into all tissue types in adults, both in vitro and in vivo. However, tumorigenicity, immunogenicity, and heterogeneity of cell populations may hamper the use of this method in medical therapeutics. The risk of cancer formation is dependent on mutations of these stemness genes during the transformation of pluripotent stem cells to cancer cells and on the alteration of the microenvironments of stem cell niches at genetic and epigenetic levels. Recent reports have shown that the generation of induced pluripotent stem cells (iPSCs) derived from human fibroblasts could be induced using chemicals, which is a safe, easy, and clinical-grade manufacturing strategy for modifying the cell fate of human cells required for regeneration therapies. This strategy is one of the future routes for the clinical application of reprogramming therapy. Therefore, this review highlights the recent progress in research focused on decreasing the tumorigenic risk of iPSCs or iPSC-derived organoids and increasing the safety of iPSC cell preparation and their application for therapeutic benefits. Full article

The thermal expansion behavior of Cu plays a critical role in the bonding mechanism of Cu/SiO₂ hybrid joints. In this study, artificial voids, which were observed to evolve using a focused ion beam, were introduced at the bonded interfaces to investigate the influence of compressive stress on bonding quality and mechanisms at elevated temperatures of 250 °C and 300 °C. The evolution of interfacial voids serves as a key indicator for assessing bonding quality. We quantified the bonding fraction and void fraction to characterize the bonding interface and found a notable increase in the bonding fraction and a corresponding decrease in the void fraction with increasing compressive stress levels. This is primarily attributed to the Cu film exhibiting greater creep/elastic deformation under higher compressive stress conditions. Furthermore, these experimental findings are supported by the surface diffusion creep model. Therefore, our study confirms that compressive stress affects the Cu–Cu bonding interface, emphasizing the need to consider the depth of Cu joints during process design. Full article

Electrochemical oxygen reduction reaction (ORR) via the 2e⁻ pathway in an acidic media shows great techno-economic potential for the production of hydrogen peroxide. Currently, carbon-based single-atom catalysts (C-SACs) have attracted extensive attention due to their tunable electronic structures, low cost, and sufficient stability in acidic media. This review summarizes recent advances in metal centers and their coordination environment in C-SACs for 2e⁻-ORR. Firstly, the reaction mechanism of 2e⁻-ORR on the active sites of C-SACs is systematically presented. Secondly, the structural regulation strategies for the active sites of 2e⁻-ORR are further summarized, including the metal active center, its species and configurations of nitrogen coordination or heteroatom coordination, and their near functional groups or substitute groups, which would provide available and proper ideas for developing superior acidic 2e⁻-ORR electrocatalysts of C-SACs. Finally, we propose the current challenges and future opportunities regarding the acidic 2e⁻-ORR pathway on C-SACs, which will eventually accelerate the development of the distributed H₂O₂ electrosynthesis process. Full article

1-(3-aryl)-3-(dimethylamino)prop-2-en-1-one (enaminones) derivatives and the diazonium salt of para-chloroaniline were used to synthesize several novel disperse azo dyes with high yield and the use of an environmentally friendly approach. At 100 and 130 °C, we dyed polyester fabrics using the new synthesized disperse dyes. At various temperatures, the dyed fabrics’ color intensity was assessed. The results we obtained showed that dyeing utilizing a high temperature method at 130 °C was enhanced than dyeing utilizing a low temperature method at 100 °C. Reusing dye baths once or twice was a way to achieve two goals at the same time. The first was obtaining a dyed product at no cost, and the second was a way to treat the wastewater of dyeing bath effluents and reuse it again. Good results were obtained for the fastness characteristics of polyester dyed with disperse dyes. When the disperse dyes were tested against certain types of microbes and cancer cells, they demonstrated good and encouraging findings for the potential to be used as antioxidants and antimicrobial agents. Full article

Accurate measurement of steroid hormones is crucial to elucidate new mechanisms of action and diagnose steroid metabolism-related diseases. This study presents a simple, sensitive, and automated analytical method for nine representative steroid hormones. The method involves on-line coupling of in-tube solid-phase microextraction (IT-SPME) with liquid chromatography–tandem mass spectrometry (LC–MS/MS). The steroid hormones were extracted and enriched on a Supel-Q PLOT capillary column using IT-SPME. Subsequently, they were separated and detected within 6 min using a Discovery HS F5-3 column and positive ion mode multiple reaction monitoring system via LC–MS/MS. Calibration curves of these compounds using each stable isotope-labeled internal standard (IS) showed linearity with correlation coefficients greater than 0.9990 in the range of 0.01–40 ng/mL, with limits of detection (S/N = 3) of 0.7–21 pg/mL. Moreover, intra- and inter-day variations were lower than 8.1 and 15% (n = 6), respectively. The recoveries of these compounds from saliva samples were in the range of 82–114%. The developed IT-SPME/LC–MS/MS method of steroid hormones is a highly sensitive, specific, and non-invasive analytical method that allows extraction and enrichment with no organic solvents, and enables direct automated online analysis by simply ultrafiltrating a small sample of saliva. Full article

This study aims to evaluate the process of neonatal phenylketonuria (PKU) screening from birth to admission to the pediatric metabolism polyclinic, determining delays in the screening program and the factors influencing them. This study was conducted during 2021–2023. Blood collection dates, results, and probable parameters causing delays in the screening program were recorded. This study included 118 infants. Admission time to the polyclinic was (mean ± SD) 25.2 ± 12.6 days (min–max: 3.4–78.9 days). Admission time was significantly high for refugees, those whose parents were consanguineous, and those who had more heel-prick blood samples taken (p < 0.001, p = 0.005, and p < 0.001, respectively). The first heel-prick blood phenylalanine (phe) level was significantly negatively correlated with the admission time (p < 0.001). Patients’ admission time whose first blood phe level < 240 μmol/L was statistically significantly higher than in those with ≥240 μmol/L (p < 0.001). We determined that there were delays in PKU screening from birth to admission to the polyclinic. Being a refugee, the presence of consanguineous marriages, the increase in the number of heel-prick tests, and blood phe levels at a range of 120–240 μmol/L were the factors that played a role in this delay. Taking steps to reduce the impact of these parameters can prevent delays in newborn PKU screening and increase the success of the screening program. Full article