Ti–Ta impedance-graded coatings were prepared using cold spraying combined with hot isostatic pressing. Compared to the general Ti–Ta binary diffusion couple, the interdiffusion coefficient of as-sprayed Ti–Ta can be increased by approximately 25 times at 1100 °C due to grain refinement at the interface of the cold-sprayed particles. By the control of interdiffusion, pure Ta and pure Ti regions can remain in the materials after hot isostatic pressing at 900 °C. Hot isostatic pressing with capsulate reduced the porosity of the material efficiently to less than 0.02%. The strength of the as-sprayed Ti–Ta composite coating was significantly improved to 990.1 MPa, and the fracture strain reached 11.5%. The strengthening mechanism of Ti–Ta composite coatings relies primarily on the hindrance of dislocation slip by phase interfaces between α and β. Moreover, the macroscopic interfacial bonding strength of the graded material exceeds 881 MPa, which is comparable to that of bulk materials. Full article

Smart cities are now embracing the new frontier of urban living, with advanced technology being used to enhance the quality of life for residents. Many of these cities have developed transportation systems that improve efficiency and sustainability, as well as quality. Integrating cutting-edge transportation technology and data-driven solutions improves safety, reduces environmental impact, optimizes traffic flow during peak hours, and reduces congestion. Intelligent transportation systems consist of many systems, one of which is traffic sign detection. This type of system utilizes many advanced techniques and technologies, such as machine learning and computer vision techniques. A variety of traffic signs, such as yield signs, stop signs, speed limits, and pedestrian crossings, are among those that the traffic sign detection system is trained to recognize and interpret. Ensuring accurate and robust traffic sign recognition is paramount for the safe deployment of self-driving cars in diverse and challenging environments like the Arab world. However, existing methods often face many challenges, such as variability in the appearance of signs, real-time processing, occlusions that can block signs, low-quality images, and others. This paper introduces an advanced Lightweight and Efficient Convolutional Neural Network (LE-CNN) architecture specifically designed for accurate and real-time Arabic traffic sign classification. The proposed LE-CNN architecture leverages the efficacy of depth-wise separable convolutions and channel pruning to achieve significant performance improvements in both speed and accuracy compared to existing models. An extensive evaluation of the LE-CNN on the Arabic traffic sign dataset that was carried out demonstrates an impressive accuracy of 96.5% while maintaining superior performance with a remarkably low inference time of 1.65 s, crucial for real-time applications in self-driving cars. It achieves high accuracy with low false positive and false negative rates, demonstrating its potential for real-world applications like autonomous driving and advanced driver-assistance systems. Full article

A new quinazolinone alkaloid named peniquinazolinone A (1), as well as eleven known compounds, 2-(2-hydroxy-3-phenylpropionamido)-N-methylbenzamide (2), viridicatin (3), viridicatol (4), (±)-cyclopeptin (5a/5b), dehydrocyclopeptin (6), cyclopenin (7), cyclopenol (8), methyl-indole-3-carboxylate (9), 2,5-dihydroxyphenyl acetate (10), methyl m-hydroxyphenylacetate (11), and conidiogenone B (12), were isolated from the endophytic Penicillium sp. HJT-A-6. The chemical structures of all the compounds were elucidated by comprehensive spectroscopic analysis, including 1D and 2D NMR and HRESIMS. The absolute configuration at C-13 of peniquinazolinone A (1) was established by applying the modified Mosher’s method. Compounds 2, 3, and 7 exhibited an optimal promoting effect on the seed germination of Rhodiola tibetica at a concentration of 0.01 mg/mL, while the optimal concentration for compounds 4 and 9 to promote Rhodiola tibetica seed germination was 0.001 mg/mL. Compound 12 showed optimal seed-germination-promoting activity at a concentration of 0.1 mg/mL. Compared with the positive drug 6-benzyladenine (6-BA), compounds 2, 3, 4, 7, 9, and 12 could extend the seed germination period of Rhodiola tibetica up to the 11th day. Full article

Heart failure (HF) remains a major medical and social problem. The NT-pro-brain natriuretic peptide (NT-proBNP) and its active form, brain-type natriuretic peptide (BNP), in a simple blood test are the gold-standard biomarkers for HF diagnosis. However, even good biomarkers such as natriuretic peptides fail to predict all the risks associated with HF due to the diversity of the mechanisms involved. The pathophysiology of HF is determined by numerous factors, including oxidative stress, inflammation, neuroendocrine activation, pathological angiogenesis, changes in apoptotic pathways, fibrosis and vascular remodeling. High readmission and mortality rates prompt a search for new markers for the diagnosis, prognosis and treatment of HF. Oxidative-stress-mediated inflammation plays a crucial role in the development of subsequent changes in the failing heart and provides a new insight into this complex mechanism. Oxidative stress and inflammatory biomarkers appear to be a promising diagnostic and prognostic tool in patients with HF. This systematic review provides an overview of the current knowledge about oxidative stress and inflammation parameters as markers of HF. Full article

Recognizing and categorizing items in weather-adverse environments poses significant challenges for autonomous vehicles. To improve the robustness of object-detection systems, this paper introduces an innovative approach for detecting objects at different levels by leveraging sensors and deep learning-based solutions within a traffic circle. The suggested approach improves the effectiveness of single-stage object detectors, aiming to advance the performance in perceiving autonomous racing environments and minimizing instances of false detection and low recognition rates. The improved framework is based on the one-stage object-detection model, incorporating multiple lightweight backbones. Additionally, attention mechanisms are integrated to refine the object-detection process further. Our proposed model demonstrates superior performance compared to the state-of-the-art method on the DAWN dataset, achieving a mean average precision (mAP) of 99.1%, surpassing the previous result of 84.7%. Full article

Epithelial–mesenchymal transition (EMT) is a process during which epithelial cells lose epithelial characteristics and gain mesenchymal features. Here, we used several cell models to study migratory activity and redistribution of cell–cell adhesion proteins in cells in different EMT states: EGF-induced EMT of epithelial IAR-20 cells; IAR-6-1 cells with a hybrid epithelial–mesenchymal phenotype; and their more mesenchymal derivatives, IAR-6-1-DNE cells lacking adherens junctions. In migrating cells, the cell–cell adhesion protein α-catenin accumulated at the leading edges along with ArpC2/p34 and α-actinin. Suppression of α-catenin shifted cell morphology from fibroblast-like to discoid and attenuated cell migration. Expression of exogenous α-catenin in MDA-MB-468 cells devoid of α-catenin drastically increased their migratory capabilities. The Y654 phosphorylated form of β-catenin was detected at integrin adhesion complexes (IACs). Co-immunoprecipitation studies indicated that α-catenin and pY654-β-catenin were associated with IAC proteins: vinculin, zyxin, and α-actinin. Taken together, these data suggest that in cells undergoing EMT, catenins not participating in assembly of adherens junctions may affect cell migration. Full article

Fresh-cut fruits, renowned for their convenience and nutritional value, are susceptible to rapid deterioration, compromising their quality and shelf life. In this study, a sustainable and environmentally friendly edible coating was developed based on sodium alginate (SA; 1% w/v), cedar mucilage (CM; 4% w/v), and calcium chloride (2% w/v), applied using a layer-by-layer technique to preserve the quality and prolong the shelf life of fresh-cut melon. Fruits were cut into cubes coated or uncoated by dipping and subsequently packaged in a polyethylene terephthalate container and stored for 15 days at 4 °C. Physicochemical traits and qualitative features such as polyphenol, flavonoid, carotenoid, ascorbic acid content, as well as antioxidant activity, were assessed. Furthermore, the enzymatic antioxidant system and the ascorbate–glutathione cycle were investigated. The coating reduced weight loss and enhanced polyphenol, flavonoid, and ascorbic acid content and antioxidant activity during cold storage. Edible coating (SA + CM) represents a valid tool to extend the postharvest life, improve the storability, and enhance the physicochemical and qualitative traits of fresh-cut melon. Further research is required to optimize coating formulations and application techniques to maximize their effectiveness and commercial viability in the food industry. Full article

In patients with end-stage renal failure requiring hemodialysis, autogenous arteriovenous fistula (AVF) is preferred over tunneled dialysis catheters due to lower complications and costs. However, AVF maturation failure remains a common issue due to small vein size, multiple venipunctures, and other factors. Guidelines recommend using vessels of >2 mm for forearm AVFs and >3 mm for upper arm AVFs. This study investigates the use of intraoperative Doppler ultrasound (DUS)-guided Balloon-Assisted Maturation (BAM) with drug-eluting balloons (DEB) during initial AVF creation. Data from 114 AVF procedures, of which 27.2% underwent BAM, were analyzed. BAM was performed in 25 distal radio-cephalic and 6 proximal brachio-cephalic AVFs. With DUS guidance, vein stenosis was identified and treated using DEB. Technical success was achieved in all cases, with no early mortality. Early BAM-related complications were minimal, and no AVF thrombosis occurred. AVF maturation time was 15 days (SD: 3), and no further complications were reported during a mean follow-up of 10.38 months. Using BAM with DEB during AVF creation led to successful maturation and dialysis use without the need for secondary procedures. This study emphasizes the importance of identifying AVF failure risk early and utilizing DUS-guided procedures to enhance AVF outcomes. A more liberal use of intraoperative BAM could limit reinterventions in patients undergoing AVFs. Full article

Madagascar is globally recognized as an important producer of high-quality flaky graphite. However, current research on graphite deposits in Madagascar remains insufficient. Previous studies have linked the genesis of Madagascan graphite deposits to the metamorphism of sedimentary organic matter. Here, we provide a case study of graphite deposits in Madagascar, combining new data from the Ambahita graphite deposit (AMG) in southern Madagascar with data from the Antanisoa graphite deposit (ANG) in central Madagascar and the Vohitasara graphite deposit (VOG) on the east coast of Madagascar. We note that the mineral assemblages of graphite-bearing rocks in the AMG, ANG, and VOG are not typical of metamorphic mineral assemblages but rather the results of filling and metasomatism by mantle-derived fluids that occurred after peak metamorphism. Electron microprobe analysis indicates that the graphite of the AMG, VOG, and ANG is usually associated with phlogopite or Mg-biotite; the phlogopite shares a common genesis with other widespread phlogopite deposits across Madagascar. We reveal that the distribution of graphite deposits in Madagascar is primarily controlled by ductile shear zones between blocks. Ductile shear zones that extend deep into the mantle can provide an ideal migration channel and architecture for the emplacement of mantle-derived fluids. The graphite mineralization formed no earlier than the peak metamorphism (490 Ma) and no later than the intrusion of pegmatite veins (389 ± 5 Ma). The distribution of graphite deposits, graphite orebody morphologies, mineral associations, and geochemical data suggest that the genesis of graphite deposits in Madagascar is linked to mantle-derived fluid filling rather than the metamorphism of sediments, as previously suggested. These findings have important implications for similar deposits in Madagascar and potentially globally. Full article

Artificial intelligence (AI)-based generative imaging systems such as DALL·E, Midjourney, Stable Diffusion, and Adobe Firefly, which work by transforming natural language descriptions into images, are revolutionizing computer vision. In this exploratory and qualitative research, we have replicated requests for images of women in different professions by comparing these representations in previous studies with DALL·E, observing that this model continues to provide in its last version, DALL·E 3, inequitable results in terms of gender. In addition, Bing Image Creator, Microsoft’s free tool that is widely used among the population and runs under DALL·E, has been tested for the first time. It also presents a sexualization of women and stereotypical children’s representations. The results reveal the following: 1. A slight improvement in terms of the presence of women in professions previously shown only with men. 2. They continue to offer biased results in terms of the objectification of women by showing sexualized women. 3. The representation of children highlights another level of gender bias, reinforcing traditional stereotypes associated with gender roles from childhood, which can impact future decisions regarding studies and occupations. Full article

Cardiac resynchronization therapy (CRT) significantly improves clinical outcomes in patients with ventricular systolic dysfunction and dyssynchrony. Biventricular pacing (BVP) has a class IA recommendation for patients with symptomatic heart failure with reduced ejection fraction (HFrEF) and left bundle branch block (LBBB). However, approximately 30% of patients have a poor therapeutic response and do not achieve real clinical benefit. Pre-implant imaging, together with tailored programming and dedicated device algorithms, have been proposed as possible tools to improve success rate but have shown inconsistent results. Over the last few years, conduction system pacing (CSP) is becoming a real and attractive alternative to standard BVP as it can restore narrow QRS in patients with bundle branch block (BBB) by stimulating and recruiting the cardiac conduction system, thus ensuring true resynchronization. It includes His bundle pacing (HBP) and left bundle branch area pacing (LBBAP). Preliminary data coming from small single-center experiences are very promising and have laid the basis for currently ongoing randomized controlled trials comparing CSP with BVP. The purpose of this review is to delve into the emerging role of CSP as an alternative method of achieving CRT. After framing CSP in a historical perspective, the pathophysiological rationale and available clinical evidence will be examined, and crucial technical aspects will be discussed. Finally, evidence gaps and future perspectives on CSP as a technique of choice to deliver CRT will be summarized. Full article

Sport injuries, including the anterior crucial ligament rupture (ACLR) seem to be related to complex genetic backgrounds, including the genes responsible for inflammatory response. This review and meta-analysis investigated the contribution of the polymorphisms of genes encoding inflammatory cytokines and their receptors to the risk of ACLR. The scientific databases Science Direct, EBSCO host, Scopus, PubMed, and Google Scholar were screened (completed on 14^th June 2023) according to the established inclusion/exclusion criteria (only fully accessible, original, human case–control studies written in English concerning the effect of interleukin genes’ polymorphisms on the occurrence of ACL injury were included) and statistical meta-analysis using R version 4.0.3 was performed. The PRISMA methodology was used to review articles. The review protocol was registered under the number CRD42024514316 in the Prospero database. Eighty-nine studies were identified and narrowed down to three original case–control studies used for the meta-analysis. The studies analyzed Polish, South African, and Swedish cohorts, altogether 1282 participants. The candidate polymorphisms indicated in the studies involved IL6 rs1800795, IL6R rs2228145 and IL1B rs16944. The systematic review showed the relationships between IL6 rs1800795 polymorphism and ACLR in the Polish subpopulation, and IL6R rs2228145 and IL1B rs16944 in the South African subpopulations. The meta-analysis revealed that the IL6 rs1800795 CG genotype was over-represented (OR = 1.30, 95% CI 1.02–1.66), while the CC genotype was under-represented (OR = 0.75, 95% CI 0.54–1.03) in ACLR subjects, but no significant impact of IL6R rs2228145 was shown. Additionally, a tendency of the IL1B rs16944 CT genotype to be protective (OR 0.89, 95% CI 0.70–1.14), while the TT to be a risk genotype (OR 1.19, 95% CI 0.84–1.68) was observed. Thus, the relationship between the interleukin receptor IL6R rs2228145 and ACLR risk was not confirmed. however, the impact of genes coding pleiotropic IL6 rs1800795 on the incidences of ACLR was clear and the effect of pro-inflammatory IL1B rs16944 was possible. Full article

Imaging spectroscopy allows us to identify surface materials by analyzing the spectra resulting from the light–material interaction. In this preliminary study, we analyze a pair of hyperspectral cubes acquired by PRISMA (on 20 April 2021) and EO1- Hyperion (on 4 July 2015) over the Indonesian Lusi mud eruption. We show the potential suitability of using the two sensors for characterizing the mineralogical features in demanding “wet and muddy” environments such as Lusi. We use spectral library reflectance spectra like Illite Chlorite from the USGS spectral library, which are known to be associated with Lusi volcanic products, to identify minerals. In addition, we have measured the reflectance spectra and composition of Lusi sampled mud collected in November 2014. Finally, we compare them with reflectance spectra from EO1-Hyperion and PRISMA. The use of hyperspectral sensors at improved SNR, such as PRISMA, has shown the potential to determine the mineral composition of Lusi PRISMA data, which allowed the distinction of areas with different turbidities as well. Artifacts in the VNIR spectral region of the L2 PRISMA reflectance product were found, suggesting that future work needs to take into account an independent atmospheric correction rather than using the L2D PRISMA product. Full article

The combined heating method of seat heating and air conditioning (A/C) was applied in the passenger compartment under different experiment conditions, using thermocouples to continuously measure the wall surfaces and air temperatures in the passenger compartment and the passengers’ skin temperatures of 17 segments. Meanwhile, a subjective evaluation questionnaire survey was conducted using a nine-point evaluation scale on the local and overall thermal sensation and thermal comfort of the passengers, and the data from the questionnaire were analyzed with the ANOVA method. The results showed that the use of the heating pad directly affected the changes in human skin temperature, which in turn affected the local and overall thermal sensation and thermal comfort. For the two thermally stimulated segments of the back and under the thighs, the skin temperature of the back was higher than that of the thighs. Using the heating pad resulted in a rapid increase in the mean skin temperature in the early period of the experiment. Thermal sensation of the back and under-thighs shifted rapidly towards the hot zone in the first 10 min, and then settled around +3, with even more significant differences between the groups. Thermal sensations in non-thermally stimulated segments changed in relation to their position on the heating pad, with slower changes in those at the “distal” end of the body, the head and the feet. Continued use of the heating pads at lower ambient temperatures maintained overall thermal comfort at a neutral level in the range of 0–1, whereas at higher ambient temperatures there was a gradual deterioration of local and overall thermal comfort. Full article

Hepatocellular carcinoma (HCC) is a heterogeneous malignancy with complex carcinogenesis. Although there has been significant progress in the treatment of HCC over the past decades, drug resistance to chemotherapy remains a major obstacle in its successful management. In this study, we were able to reduce chemoresistance in cisplatin-resistant HepG2 cells by either silencing the expression of transglutaminase type 2 (TG2) using siRNA or by the pre-treatment of cells with the TG2 enzyme inhibitor cystamine. Further analysis revealed that, whereas the full-length TG2 isoform (TG2-L) was almost completely cytoplasmic in its distribution, the majority of the short TG2 isoform (TG2-S) was membrane-associated in both parental and chemoresistant HepG2 cells. Following the induction of cisplatin toxicity in non-chemoresistant parental cells, TG2-S, together with cisplatin, quickly relocated to the cytosolic fraction. Conversely, no cytosolic relocalisation of TG2-S or nuclear accumulation cisplatin was observed, following the identical treatment of chemoresistant cells, where TG2-S remained predominantly membrane-associated. This suggests that the deficient subcellular relocalisation of TG2-S from membranous structures into the cytoplasm may limit the apoptic response to cisplatin toxicity in chemoresistant cells. Structural analysis of TG2 revealed the presence of binding motifs for interaction of TG2-S with the membrane scaffold protein LC3/LC3 homologue that could contribute to a novel mechanism of chemotherapeutic resistance in HepG2 cells Full article

This review outlines the evolutionary journey from traditional two-dimensional (2D) cell culture to the revolutionary field of organ-on-a-chip technology. Organ-on-a-chip technology integrates microfluidic systems to mimic the complex physiological environments of human organs, surpassing the limitations of conventional 2D cultures. This evolution has opened new possibilities for understanding cell–cell interactions, cellular responses, drug screening, and disease modeling. However, the design and manufacture of microchips significantly influence their functionality, reliability, and applicability to different biomedical applications. Therefore, it is important to carefully consider design parameters, including the number of channels (single, double, or multi-channels), the channel shape, and the biological context. Simultaneously, the selection of appropriate materials compatible with the cells and fabrication methods optimize the chips’ capabilities for specific applications, mitigating some disadvantages associated with these systems. Furthermore, the success of organ-on-a-chip platforms greatly depends on the careful selection and utilization of cell resources. Advances in stem cell technology and tissue engineering have contributed to the availability of diverse cell sources, facilitating the development of more accurate and reliable organ-on-a-chip models. In conclusion, a holistic perspective of in vitro cellular modeling is provided, highlighting the integration of microfluidic technology and meticulous chip design, which play a pivotal role in replicating organ-specific microenvironments. At the same time, the sensible use of cell resources ensures the fidelity and applicability of these innovative platforms in several biomedical applications. Full article

The naturally occurring compounds ecdysterone and turkesterone, which are present in plants, including Rhaponticum carthamoides Willd. (Iljin), Spinacia oleracea L., Chenopodium quinoa Willd., and Ajuga turkestanica (Regel) Briq, are widely recognized due to their possible advantages for both general health and athletic performance. The current review investigates the beneficial biological effects of ecdysterone and turkesterone in nutrition, highlighting their roles not only in enhancing athletic performance but also in the management of various health problems. Plant-based diets, associated with various health benefits and environmental sustainability, often include sources rich in phytoecdysteroids. However, the therapeutic potential of phytoecdysteroid-rich extracts extends beyond sports nutrition, with promising applications in treating chronic fatigue, cardiovascular diseases, and neurodegenerative disorders. Full article

The transport properties of molecular devices based on carbon chains are systematically investigated using a combination of non-equilibrium Green’s function (NEGF) and density functional theory (DFT) first-principle methods. In single-carbon-chain molecular devices, a distinct even–odd behavior of the current emerges, primarily influenced by the density of states (DOS) within the chain channel. Additionally, linear, monotonic currents exhibit Ohmic contact characteristics. In ladder-shaped carbon-chain molecular devices, a notable current stabilization behavior is observed, suggesting their potential utility as current stabilizers within circuits. We provide a comprehensive analysis of the transport properties of molecular devices featuring ladder-shaped carbon chains connecting benzene-ring molecules. The occurrence of negative differential resistance (NDR) in the low-bias voltage region is noted, with the possibility of manipulation by adjusting the position of the benzene-ring molecule. These findings offer a novel perspective on the potential applications of atom chains. Full article

Aiming at the problem that silicon-controlled rectifiers (SCR) and pulse width modulation (PWM) rectifiers cannot balance high power levels, high hydrogen production efficiency, and high grid connected quality in the current research on rectifier power supplies for electrolytic hydrogen production, a new hybrid rectifier topology based on a modular multilevel converter (MMC) is proposed. The hybrid topology integrates a silicon-controlled rectifier (SCR) with an auxiliary power converter, wherein the SCR is designated as the primary power source for electrolytic hydrogen production. The auxiliary converter employs a cascaded modular multilevel converter (MMC) and an input-series-output-parallel (ISOP) phase-shifted full-bridge (PSFB) arrangement. This configuration allows the auxiliary converter to effectively mitigate AC-side harmonics and minimize DC-side ripple, concurrently transmitting a small amount of power. The effectiveness of the hybrid rectifier in achieving low ripple and harmonic distortion outputs was substantiated through hardware-in-the-loop experiments. Notably, the hybrid topology is characterized by its enhanced electric-to-hydrogen conversion efficiency, elevated power density, cost efficiency, and improved grid compatibility. Full article

The concept of sustainable healthcare is the subject of an increasingly intense, captivating, forward-looking, yet sometimes still overly theoretical debate. The aim of this contribution is to analyze the current scenarios of ecological and digital transition in the healthcare sector, considering its high energy consumption. In particular, we adopt a holistic and convergent vision of the energy mix and its infrastructure, moving beyond the ideological dichotomy of energy sources. Renewable sources, digital innovations, and the circular economy are seen as playing key roles in the future of the energy sector. In this research, a mixed methodology was employed, combining a questionnaire consisting of 31 questions with semi-structured interviews conducted with the top management of a major player in the private healthcare sector located in southern Italy in 2023. Consequently, we examine the main macro-guidelines of technological development, encompassing enabling technologies, new business models, roles, and professional skills. Based on the analyses conducted, we provide some insights to inform governmental policies and industrial strategies in the near future. Digitalization represents an opportunity to enhance the efficiency of healthcare services, reducing waste and ensuring quality. For instance, digital healthcare solutions enable personalized care on a global scale and offer decision support systems that can enhance overall healthcare performance. However, to maximize the benefits of digital transformation, it is essential to integrate new technologies effectively and sustainably into the existing healthcare ecosystem. A promising example is telemedicine, which can help reduce carbon emissions by decreasing healthcare workers’ travel. Full article

Simplified methods are often used for load estimations during the initial design of the foundations of offshore wind turbines (OWTs). However, the reliability of simplified methods for designing different OWTs needs to be studied. This paper provides a comparative study to evaluate the reliability of simplified approaches. The foundation loads are calculated for OWTs at the mudline level using a simplified approach and OpenFAST simulations and compared. Three OWTs, NREL 5 MW, DTU 10 MW, and IEA 15 MW, are used as reference models. An Extreme Turbulence Model wind load at a rated wind speed, combined with a 50-year Extreme Wave Height (EWH) and Extreme Operating Gust (EOG) wind load and a 1-year maximum wave height are used as the load combinations in this study. In addition, the extreme loads are calculated using both approaches for various metocean data from five different wind farms. Further, the pile penetration lengths calculated using the mudline loads via two methods are compared. The results show that the simplified method provides conservative results for the estimated loads compared to the OpenFAST results, where the extent of conservativism is studied. For example, the bending moment and shear force at the mudline using the simplified approach are 23% to 69% and 32% to 53% higher compared to the OpenFAST results, respectively. In addition, the results show that the simplified approach can be effectively used during the initial phases of monopile foundation design by using factors such as 1.5 and 2 for the shear force and bending moment, respectively. Full article

Knee injuries represent a significant health concern for young male football players in Saudi Arabia. Despite global research on football-related injuries, there is a distinct lack of studies focusing on this demographic in the Saudi context. This research aims to fill this gap, offering insights into injury prevalence and risk factors, thereby contributing to athlete well-being and informing tailored interventions. This study aimed to investigate the prevalence of knee injuries among youth male football players in Saudi Arabia, with a focus on injury patterns, risk factors, and associated factors. A cross-sectional study was conducted, involving 104 male football players who represent five Saudi clubs and are aged 18.82 ± 0.68 years. Injury data, including severity, timing, and mechanisms, were collected. Logistic regression analyses were performed to assess the impact of various factors on the likelihood of knee injuries. The study revealed that 37.5% of participants reported prior knee injuries, predominantly muscle injuries (61.5%) occurring during training. Ligamentous injuries, particularly anterior cruciate ligament injuries, were also notable (25.6%). Logistic regression analyses indicated that factors such as age, weight, height, body mass index, playing position, duration of playing football, and playing surface significantly influenced the odds of sustaining a knee injury. This study provides insights into the prevalence and patterns of knee injuries among youth male football players in the central region of Saudi Arabia. Muscle injuries are common. Factors such as age, weight, and playing position contribute to the risk of knee injuries. The findings underscore the need for targeted injury prevention strategies and player education programs. Full article