The 2023 MDPI Annual Report has
been released!
 
14 pages, 1184 KiB  
Article
Low Bone Mineral Density on Computed Tomography: Association with Poor Survival after Transcatheter Aortic Valve Replacement
by Caglayan Demirel, Kseniya Halavina, Kevin Hamzaraj, Johanna Klement, Manar El-Shaer, Rayyan Hemetsberger, Max Paul Winter, Sophia Koschatko, Charlotte Jantsch, Martin Andreas, Christian Loewe, Andreas Kammerlander, Christian Hengstenberg and Philipp E. Bartko
J. Clin. Med. 2024, 13(9), 2698; https://doi.org/10.3390/jcm13092698 (registering DOI) - 03 May 2024
Abstract
Background: Transcatheter aortic valve replacement (TAVR) has evolved as first-line therapy for severe aortic valve stenosis (AS), with pre-procedural computed tomography (CT) providing critical anatomical information. While primarily used for anatomical planning, TAVR-CT also offers an opportunity to assess low bone mineral density [...] Read more.
Background: Transcatheter aortic valve replacement (TAVR) has evolved as first-line therapy for severe aortic valve stenosis (AS), with pre-procedural computed tomography (CT) providing critical anatomical information. While primarily used for anatomical planning, TAVR-CT also offers an opportunity to assess low bone mineral density (BMD), a known indicator of frailty. Despite this, the prognostic role of BMD in TAVR patients remains unknown. This study aimed to evaluate BMD on routine TAVR-CT and its impact on long-term survival. Methods: In this retrospective study, 770 consecutive TAVR patients (mean age 80.7 ± 6.7 years, 54.0% males) between November 2015 and March 2022 were included. BMD was measured from a single axial image at the thoracic vertebral level on unenhanced CT scans. Cox regression models assessed the impact of BMD on mortality, and Restricted Cubic Spline models identified potential mortality thresholds. Results: The mean BMD value, as measured on non-contrast CT, was 147.5 ± 5.4 Hounsfield units, demonstrating a noteworthy association with mortality (adjusted hazard ratio per 100 HU decrease: 1.27 [95% CI: 1.01–1.59], p = 0.041). Restricted cubic spline analysis indicated that BMD below 200 HU was linked to a substantial increase in mortality risk. Upon crude Cox regression analysis, every 100 HU decrease was associated with a 32% increase in risk for death (HR 1.32 [95%CI: 1.068–1.65)], p = 0.010). Conclusions: In conclusion, low BMD on TAVR-CT is independently associated with reduced survival, suggesting its potential as a tool for comprehensive frailty assessment and improved risk prediction in TAVR patients. Full article
(This article belongs to the Special Issue Valvular Heart Disease: Challenges and New Opportunities)
27 pages, 9009 KiB  
Article
Temporal Variations in Land Surface Temperature within an Urban Ecosystem: A Comprehensive Assessment of Land Use and Land Cover Change in Kharkiv, Ukraine
by Gareth Rees, Liliia Hebryn-Baidy and Vadym Belenok
Remote Sens. 2024, 16(9), 1637; https://doi.org/10.3390/rs16091637 (registering DOI) - 03 May 2024
Abstract
Remote sensing technologies are critical for analyzing the escalating impacts of global climate change and increasing urbanization, providing vital insights into land surface temperature (LST), land use and cover (LULC) changes, and the identification of urban heat island (UHI) and surface urban heat [...] Read more.
Remote sensing technologies are critical for analyzing the escalating impacts of global climate change and increasing urbanization, providing vital insights into land surface temperature (LST), land use and cover (LULC) changes, and the identification of urban heat island (UHI) and surface urban heat island (SUHI) phenomena. This research focuses on the nexus between LULC alterations and variations in LST and air temperature (Tair), with a specific emphasis on the intensified SUHI effect in Kharkiv, Ukraine. Employing an integrated approach, this study analyzes time-series data from Landsat and MODIS satellites, alongside Tair climate records, utilizing machine learning techniques and linear regression analysis. Key findings indicate a statistically significant upward trend in Tair and LST during the summer months from 1984 to 2023, with a notable positive correlation between Tair and LST across both datasets. MODIS data exhibit a stronger correlation (R2 = 0.879) compared to Landsat (R2 = 0.663). The application of a supervised classification through Random Forest algorithms and vegetation indices on LULC data reveals significant alterations: a 70.3% increase in urban land and a decrement in vegetative cover comprising a 15.5% reduction in dense vegetation and a 62.9% decrease in sparse vegetation. Change detection analysis elucidates a 24.6% conversion of sparse vegetation into urban land, underscoring a pronounced trajectory towards urbanization. Temporal and seasonal LST variations across different LULC classes were analyzed using kernel density estimation (KDE) and boxplot analysis. Urban areas and sparse vegetation had the smallest average LST fluctuations, at 2.09 °C and 2.16 °C, respectively, but recorded the most extreme LST values. Water and dense vegetation classes exhibited slightly larger fluctuations of 2.30 °C and 2.24 °C, with the bare land class showing the highest fluctuation 2.46 °C, but fewer extremes. Quantitative analysis with the application of Kolmogorov-Smirnov tests across various LULC classes substantiated the normality of LST distributions p > 0.05 for both monthly and annual datasets. Conversely, the Shapiro-Wilk test validated the normal distribution hypothesis exclusively for monthly data, indicating deviations from normality in the annual data. Thresholded LST classifies urban and bare lands as the warmest classes at 39.51 °C and 38.20 °C, respectively, and classifies water at 35.96 °C, dense vegetation at 35.52 °C, and sparse vegetation 37.71 °C as the coldest, which is a trend that is consistent annually and monthly. The analysis of SUHI effects demonstrates an increasing trend in UHI intensity, with statistical trends indicating a growth in average SUHI values over time. This comprehensive study underscores the critical role of remote sensing in understanding and addressing the impacts of climate change and urbanization on local and global climates, emphasizing the need for sustainable urban planning and green infrastructure to mitigate UHI effects. Full article
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22 pages, 56171 KiB  
Article
Growing in Scarcity: Pre-Hispanic Rain-Fed Agriculture in the Semi-Arid and Frost-Prone Andean Altiplano (Bolivia)
by Pablo Cruz, Richard Joffre, Thibault Saintenoy and Jean-Joinville Vacher
Land 2024, 13(5), 619; https://doi.org/10.3390/land13050619 (registering DOI) - 03 May 2024
Abstract
Ancient Andean agricultural landscapes have been the subject of a large number of archaeological and agro-ecological studies, which generally refer to regions with favourable environmental conditions or, in the case of arid and semi-arid environments, those with irrigation facilities. The aim of this [...] Read more.
Ancient Andean agricultural landscapes have been the subject of a large number of archaeological and agro-ecological studies, which generally refer to regions with favourable environmental conditions or, in the case of arid and semi-arid environments, those with irrigation facilities. The aim of this article is to present and analyse the pre-Hispanic rain-fed farming systems widely represented in two adjacent regions of Bolivia’s arid and cold southern Altiplano. The search for archaeological agricultural areas combined aerial analysis and field surveys. Agro-ecological characterisation was based on historical and ethnographic studies of the region’s present-day populations. Despite their geographical proximity, similar environmental conditions, and same agropastoral way of life, the typology of cultivated areas developed in the southern altiplano differs significantly. Within this same framework of adaptation and resilience, the sectorisation of agricultural systems observed in these two regions reveals a regional productive specialisation that favoured internal exchanges and exchanges with other regions. These differences are related to two models of non-centralised, low-inequality societies—one strongly based on cohesion and the other characterised by greater fragmentation and social conflict—underlining the limits of strict environmental determinism in shaping agricultural landscapes. These results provide new food for thought in the debate on the use and value of rain-fed agricultural practices and more broadly on the diversity of adaptations by human societies in extreme and unstable environmental contexts. Full article
15 pages, 1301 KiB  
Review
The Role of Galectins in Asthma Pathophysiology: A Comprehensive Review
by Andrea Portacci, Ilaria Iorillo, Leonardo Maselli, Monica Amendolara, Vitaliano Nicola Quaranta, Silvano Dragonieri and Giovanna Elisiana Carpagnano
Curr. Issues Mol. Biol. 2024, 46(5), 4271-4285; https://doi.org/10.3390/cimb46050260 (registering DOI) - 03 May 2024
Abstract
Galectins are a group of β-galactoside-binding proteins with several roles in immune response, cellular adhesion, and inflammation development. Current evidence suggest that these proteins could play a crucial role in many respiratory diseases such as pulmonary fibrosis, lung cancer, and respiratory infections. From [...] Read more.
Galectins are a group of β-galactoside-binding proteins with several roles in immune response, cellular adhesion, and inflammation development. Current evidence suggest that these proteins could play a crucial role in many respiratory diseases such as pulmonary fibrosis, lung cancer, and respiratory infections. From this standpoint, an increasing body of evidence have recognized galectins as potential biomarkers involved in several aspects of asthma pathophysiology. Among them, galectin-3 (Gal-3), galectin-9 (Gal-9), and galectin-10 (Gal-10) are the most extensively studied in human and animal asthma models. These galectins can affect T helper 2 (Th2) and non-Th2 inflammation, mucus production, airway responsiveness, and bronchial remodeling. Nevertheless, while higher Gal-3 and Gal-9 concentrations are associated with a stronger degree of Th-2 phlogosis, Gal-10, which forms Charcot–Leyden Crystals (CLCs), correlates with sputum eosinophilic count, interleukin-5 (IL-5) production, and immunoglobulin E (IgE) secretion. Finally, several galectins have shown potential in clinical response monitoring after inhaled corticosteroids (ICS) and biologic therapies, confirming their potential role as reliable biomarkers in patients with asthma. Full article
(This article belongs to the Section Molecular Medicine)
15 pages, 11625 KiB  
Article
Non-Linear Dynamics of Simple Elastic Systems Undergoing Friction-Ruled Stick–Slip Motions
by Riccardo Barsotti, Stefano Bennati and Giovanni Migliaccio
CivilEng 2024, 5(2), 420-434; https://doi.org/10.3390/civileng5020021 (registering DOI) - 03 May 2024
Abstract
The stick–slip phenomenon is a jerking motion that can occur while two objects slide over each other with friction. There are several situations in which this phenomenon can be observed: between the slabs of the friction dampers used to mitigate vibrations in buildings, [...] Read more.
The stick–slip phenomenon is a jerking motion that can occur while two objects slide over each other with friction. There are several situations in which this phenomenon can be observed: between the slabs of the friction dampers used to mitigate vibrations in buildings, as well as between the components of the base isolation systems used for seismic protection. The systems of this kind are usually designed to work in a smooth and flawless manner, but under particular conditions undesired jerking motions may develop, yielding complex dynamic behavior even when only a few degrees of freedom are involved. A simplified approach to the problems of this kind leads to the mechanical model of a rigid block connected elastically to a rigid support and at the same time with friction to a second rigid support, both the supports having a prescribed motion. Despite the apparent simplicity of this model, it is very useful for studying important features of the non-linear dynamics of many physical systems. In this work, after a suitable formulation of the problem, the equations of motion are solved analytically in the sticking and sliding phases, and the influence of the main parameters of the system on its dynamics and limit cycles is investigated and discussed. Full article
(This article belongs to the Special Issue "Stability of Structures", in Memory of Prof. Marcello Pignataro)
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11 pages, 4167 KiB  
Article
Hydrogen Formation from Water with Various Reducing Metals Catalyzed by In Situ-Generated Nickel Nanoparticles
by Ron Shirman and Yoel Sasson
Hydrogen 2024, 5(2), 230-240; https://doi.org/10.3390/hydrogen5020014 (registering DOI) - 03 May 2024
Abstract
Water is a potential green source for the generation of clean elemental hydrogen without contaminants. One of the most convenient methods for hydrogen generation is based on the oxidation of different metals by water. The inspection of the catalytic activity toward hydrogen formation [...] Read more.
Water is a potential green source for the generation of clean elemental hydrogen without contaminants. One of the most convenient methods for hydrogen generation is based on the oxidation of different metals by water. The inspection of the catalytic activity toward hydrogen formation from water performed in this study was carried out using four different metals, namely, zinc, magnesium, iron, and manganese. The process is catalyzed by in situ-generated nickel nanoparticles. The zinc–water system was found to be the most effective and exhibited 94% conversion in 4 h. The solid phase in the latter system was characterized by PXRD and SEM techniques. Several blank tests provided a fundamental understanding of the role of each constituent within the system, and a molecular mechanism for the catalytic cycle was proposed. Full article
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19 pages, 9357 KiB  
Article
Quantification of Fundamental Textile Properties of Electronic Textiles Fabricated Using Different Techniques
by Arash M. Shahidi, Kalana Marasinghe, Parvin Ebrahimi, Jane Wood, Zahra Rahemtulla, Philippa Jobling, Carlos Oliveira, Tilak Dias and Theo Hughes-Riley
Textiles 2024, 4(2), 218-236; https://doi.org/10.3390/textiles4020013 (registering DOI) - 03 May 2024
Abstract
Electronic textiles (E-textiles) have experienced an increase in interest in recent years leading to a variety of new concepts emerging in the field. Despite these technical innovations, there is limited literature relating to the testing of E-textiles for some of the fundamental properties [...] Read more.
Electronic textiles (E-textiles) have experienced an increase in interest in recent years leading to a variety of new concepts emerging in the field. Despite these technical innovations, there is limited literature relating to the testing of E-textiles for some of the fundamental properties linked to wearer comfort. As such, this research investigates four fundamental properties of E-textiles: air permeability, drape, heat transfer, and moisture transfer. Three different types of E-textiles were explored: an embroidered electrode, a knitted electrode, and a knitted structure with an embedded electronic yarn. All of the E-textiles utilized the same base knitted fabric structure to facilitate a comparative study. The study used established textile testing practices to evaluate the E-textiles to ascertain the suitability of these standards for these materials. The study provides a useful point of reference to those working in the field and highlights some limitations of existing textile testing methodologies when applied to E-textiles. Full article
(This article belongs to the Special Issue Advances in Smart Textiles)
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14 pages, 1596 KiB  
Article
An Analysis of the Main Nutrient Components of the Fruits of Different Macadamia (Macadamia integrifolia) Cultivars in Rocky Desertification Areas and a Comprehensive Evaluation of the Mineral Element Contents
by Zhuanmiao Kang, Guangzheng Guo, Fengping He, Hui Zeng, Xinghao Tu and Wenlin Wang
Horticulturae 2024, 10(5), 468; https://doi.org/10.3390/horticulturae10050468 (registering DOI) - 03 May 2024
Abstract
This study aims to understand the main nutrient composition and comprehensively evaluate the differences in the mineral element contents of fruits of different macadamia cultivars, as well as screen good cultivars that are suitable for use in rocky desert mountains. Nine macadamia nut [...] Read more.
This study aims to understand the main nutrient composition and comprehensively evaluate the differences in the mineral element contents of fruits of different macadamia cultivars, as well as screen good cultivars that are suitable for use in rocky desert mountains. Nine macadamia nut cultivars were selected as test materials in rocky desert mountain orchards. The contents of crude fat, crude protein, and total soluble sugar in kernels and N, P, K, Ca, Mg, Fe, Mn, Cu, Zn, and B in peels and kernels were determined, respectively. Then, the kernels’ mineral element contents were comprehensively evaluated based on principal component analysis. The results showed that the kernels were rich in crude fat, protein, and soluble sugar, with the crude fat content reaching 75% or greater, and the variation among cultivars was small. However, the variation in soluble sugar content was extensive. The content of mineral elements varied in different cultivars and parts of the fruit, with the average macronutrient content being K > N > Ca > P > Mg in the pericarp and N > K > P > Mg > Ca in the kernel, and the content of micronutrients in the pericarp and the kernel being Mn > Fe > Zn > Cu > B. By principal component analysis, the 10 mineral nutrient indexes were calculated as four principal components, with a cumulative contribution rate of 88.051%. Using the affiliation function value method and the calculation of the comprehensive evaluation value, the nine cultivars could be classified into three categories. The cultivar with the highest comprehensive evaluation value of the mineral element content was O.C. The one with the lowest value was H2, which indicated that O.C is a suitable variety for popularization in rocky desert mountainous areas. Stepwise regression analysis concluded that P, K, Fe, Mn, and Cu were the indicators significantly influencing the mineral element content of macadamia nuts and fruits in rocky desert mountains. Full article
(This article belongs to the Special Issue Fertilizer Usage and Nutrient Management in Horticultural Crops)
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13 pages, 2526 KiB  
Article
Toe Box Shape of Running Shoes Affects In-Shoe Foot Displacement and Deformation: A Randomized Crossover Study
by Chengyuan Zhu, Yang Song, Yufan Xu, Aojie Zhu, Julien S. Baker, Wei Liu and Yaodong Gu
Bioengineering 2024, 11(5), 457; https://doi.org/10.3390/bioengineering11050457 (registering DOI) - 03 May 2024
Abstract
Background: Long-distance running is popular but associated with a high risk of injuries, particularly toe-related injuries. Limited research has focused on preventive measures, prompting exploration into the efficacy of raised toe box running shoes. Purpose: This study aimed to investigate the effect of [...] Read more.
Background: Long-distance running is popular but associated with a high risk of injuries, particularly toe-related injuries. Limited research has focused on preventive measures, prompting exploration into the efficacy of raised toe box running shoes. Purpose: This study aimed to investigate the effect of running shoes with raised toe boxes on preventing toe injuries caused by distance running. Methods: A randomized crossover design involved 25 male marathon runners (height: 1.70 ± 0.02 m, weight: 62.6 + 4.5 kg) wearing both raised toe box (extended by 8 mm along the vertical axis and 3 mm along the sagittal axis) and regular toe box running shoes. Ground reaction force (GRF), in-shoe displacement, and degree of toe deformation (based on the distance change between the toe and the metatarsal head) were collected. Results: Wearing raised toe box shoes resulted in a significant reduction in vertical (p = 0.001) and antero–posterior (p = 0.015) ground reaction forces during the loading phase, with a notable increase in vertical ground reaction force during the toe-off phase (p < 0.001). In-shoe displacement showed significant decreased movement in the forefoot medial (p < 0.001) and rearfoot (medial: p < 0.001, lateral: p < 0.001) and significant increased displacement in the midfoot (medial: p = 0.002, lateral: p < 0.001). Impact severity on the hallux significantly decreased (p < 0.001), while impact on the small toes showed no significant reduction (p = 0.067). Conclusions: Raised toe box running shoes offer an effective means of reducing toe injuries caused by long-distance running. Full article
(This article belongs to the Special Issue Multiscale Modeling in Computational Biomechanics)
13 pages, 2028 KiB  
Article
Ionic Conductivity Analysis of NASICON Solid Electrolyte Coated with Polyvinyl-Based Polymers
by Tiago Afonso Salgueiro, Rita Carvalho Veloso, João Ventura, Federico Danzi and Joana Oliveira
Batteries 2024, 10(5), 157; https://doi.org/10.3390/batteries10050157 (registering DOI) - 03 May 2024
Abstract
The global environmental crisis necessitates reliable, sustainable, and safe energy storage solutions. The current systems are nearing their capacity limits due to the reliance on conventional liquid electrolytes, which are fraught with stability and safety concerns, prompting the exploration of solid-state electrolytes, which [...] Read more.
The global environmental crisis necessitates reliable, sustainable, and safe energy storage solutions. The current systems are nearing their capacity limits due to the reliance on conventional liquid electrolytes, which are fraught with stability and safety concerns, prompting the exploration of solid-state electrolytes, which enable the integration of metal electrodes. Solid-state sodium-ion batteries emerge as an appealing option by leveraging the abundance, low cost, and sustainability of sodium. However, low ionic conductivity and high interfacial resistance currently prevent their widespread adoption. This study explores polyvinyl-based polymers as wetting agents for the NASICON-type NZSP (Na3Zr2Si2PO12) solid electrolyte, resulting in a combined system with enhanced ionic conductivity suitable for Na-ion solid-state full cells. Electrochemical impedance spectroscopy (EIS) performed on symmetric cells employing NZSP paired with different wetting agent compositions demonstrates a significant reduction in interfacial resistance with the use of poly(vinyl acetate)—(PVAc-) based polymers, achieving an impressive ionic conductivity of 1.31 mS cm−1 at room temperature, 63.8% higher than the pristine material, notably reaching 7.36 mS cm−1 at 90 °C. These results offer valuable insights into the potential of PVAc-based polymers for advancing high-performance solid-state sodium-ion batteries by reducing their total internal resistance. Full article
(This article belongs to the Collection Advances in Battery Materials)
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18 pages, 5269 KiB  
Article
Combining Transcriptome- and Metabolome-Analyzed Differentially Expressed Genes and Differential Metabolites in Development Period of Caoyuanheimo-1 (Agaricus sp.) from Inner Mongolia, China
by Hai-yan Wang, Ya-nan Lu, Ya-jiao Li, Guo-qin Sun, Yuan Wu, Rui-qing Ji and Wei Yan
Horticulturae 2024, 10(5), 469; https://doi.org/10.3390/horticulturae10050469 (registering DOI) - 03 May 2024
Abstract
Caoyuanheimo-1 (Agaricus sp.) is a delectable mushroom native to Inner Mongolia, China, belonging to the Agaricus genus and valued for both its edible and medicinal properties. Although it has been cultivated to a certain extent, the molecular mechanisms regulating its development remain [...] Read more.
Caoyuanheimo-1 (Agaricus sp.) is a delectable mushroom native to Inner Mongolia, China, belonging to the Agaricus genus and valued for both its edible and medicinal properties. Although it has been cultivated to a certain extent, the molecular mechanisms regulating its development remain poorly understood. Building on our understanding of its growth and development conditions at various stages, we conducted transcriptomic and metabolomic studies to identify the differentially expressed genes (DEGs) and metabolites throughout its growth cycle. Simultaneously, we analyzed the synthesis pathways and identified several key genes involved in the production of terpenoids, which are secondary metabolites with medicinal value widely found in mushrooms. A total of 6843 unigenes were annotated, and 449 metabolites were detected in our study. Many of these metabolites and differentially expressed genes (DEGs) are involved in the synthesis and metabolism of amino acids, such as arginine, cysteine, methionine, and other amino acids, which indicates that the genes related to amino acid metabolism may play an important role in the fruiting body development of Caoyuanheimo-1. Succinic acid also showed a significant positive correlation with the transcriptional level changes of nine genes, including laccase-1 (TRINITY_DN5510_c0_g1), fruiting body protein SC3 (TRINITY_DN3577_c0_g1), and zinc-binding dihydrogenase (TRINITY_DN2099_c0_g1), etc. Additionally, seventeen terpenoids and terpenoid-related substances were identified, comprising five terpenoid glycosides, three monoterpenoids, two diterpenoids, one sesquiterpenoid, one sesterterpenoid, two terpenoid lactones, and three triterpenoids. The expression levels of the genes related to terpenoid synthesis varied across the three developmental stages. Full article
27 pages, 15086 KiB  
Article
Vision-Guided Tracking and Emergency Landing for UAVs on Moving Targets
by Yisak Debele, Ha-Young Shi, Assefinew Wondosen, Henok Warku, Tae-Wan Ku and Beom-Soo Kang
Drones 2024, 8(5), 182; https://doi.org/10.3390/drones8050182 (registering DOI) - 03 May 2024
Abstract
This paper presents a vision-based adaptive tracking and landing method for multirotor Unmanned Aerial Vehicles (UAVs), designed for safe recovery amid propulsion system failures that reduce maneuverability and responsiveness. The method addresses challenges posed by external disturbances such as wind and agile target [...] Read more.
This paper presents a vision-based adaptive tracking and landing method for multirotor Unmanned Aerial Vehicles (UAVs), designed for safe recovery amid propulsion system failures that reduce maneuverability and responsiveness. The method addresses challenges posed by external disturbances such as wind and agile target movements, specifically, by considering maneuverability and control limitations caused by propulsion system failures. Building on our previous research in actuator fault detection and tolerance, our approach employs a modified adaptive pure pursuit guidance technique with an extra adaptation parameter to account for reduced maneuverability, thus ensuring safe tracking of moving objects. Additionally, we present an adaptive landing strategy that adapts to tracking deviations and minimizes off-target landings caused by lateral tracking errors and delayed responses, using a lateral offset-dependent vertical velocity control. Our system employs vision-based tag detection to ascertain the position of the Unmanned Ground Vehicle (UGV) in relation to the UAV. We implemented this system in a mid-mission emergency landing scenario, which includes actuator health monitoring of emergency landings. Extensive testing and simulations demonstrate the effectiveness of our approach, significantly advancing the development of safe tracking and emergency landing methods for UAVs with compromised control authority due to actuator failures. Full article
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15 pages, 28321 KiB  
Article
Study of Orifice Design on Oleo-Pneumatic Shock Absorber
by Paulo A. S. F. Silva, Ahmed A. Sheikh Al-Shabab, Panagiotis Tsoutsanis and Martin Skote
Fluids 2024, 9(5), 108; https://doi.org/10.3390/fluids9050108 (registering DOI) - 03 May 2024
Abstract
Aircraft oil-strut shock absorbers rely on orifice designs to control fluid flow and optimize damping performance. However, the complex nature of cavitating flows poses significant challenges in predicting the influence of orifice geometry on energy dissipation and system reliability. This study presents a [...] Read more.
Aircraft oil-strut shock absorbers rely on orifice designs to control fluid flow and optimize damping performance. However, the complex nature of cavitating flows poses significant challenges in predicting the influence of orifice geometry on energy dissipation and system reliability. This study presents a comprehensive computational fluid dynamics (CFD) analysis of the effects of circular, rectangular, semicircular, and cutback orifice profiles on the internal flow characteristics and damping behavior of oleo-pneumatic shock absorbers. High-fidelity simulations reveal that the rectangular orifice generates higher damping pressures and velocity magnitude than those generated by others designs, while the semicircular shape reduces cavitation inception and exhibits a more gradual pressure recovery. Furthermore, the study highlights the importance of considering both geometric and thermodynamic factors in the design and analysis of cavitating flow systems, as liquid properties and vapor pressure significantly impact bubble growth and collapse behavior. Increasing the orifice length had a negligible impact on damping but moderately raised orifice velocities. This research provides valuable insights for optimizing shock absorber performance across a range of operating conditions, ultimately enhancing vehicle safety and passenger comfort. Full article
(This article belongs to the Special Issue Turbulent Flow, 2nd Edition)
14 pages, 815 KiB  
Article
Developing the Physical Performance in Youth Soccer: Short-Term Effect of Dynamic–Ecological Versus Traditional Training Approach for Sub-Elite U13 Players—An Ecological Exploratory Cluster Randomised Trial
by Italo Sannicandro, Samuel Agostino, Massimiliano Abate Daga, Franco Veglio and Federico Abate Daga
J. Funct. Morphol. Kinesiol. 2024, 9(2), 83; https://doi.org/10.3390/jfmk9020083 (registering DOI) - 03 May 2024
Abstract
Currently, research in youth soccer consists of methodological choices that can raise activity volumes and exercise intensity to promote proper training for youth soccer demands. Therefore, the present cluster randomised trial aims to evaluate the effects of the dynamic–ecological approach on the physical [...] Read more.
Currently, research in youth soccer consists of methodological choices that can raise activity volumes and exercise intensity to promote proper training for youth soccer demands. Therefore, the present cluster randomised trial aims to evaluate the effects of the dynamic–ecological approach on the physical performance parameters compared with a traditional one in a group of sub-elite U13 players. Thirty-five male children (age 12.16 ± 0.55 years; weight 45.59 ± 7.15 kg; height 145.5 ± 4.2 cm; BMI 15.8 ± 2.1 kg·m−2) were recruited for this trial from two teams belonging to sub-elite soccer schools and randomly assigned to a dynamic–ecological approach (DEA) or a traditional training (TTG) group. The training program lasted six weeks and consisted of 18 training sessions of 90 min each (3 sessions per week). The sample was evaluated by the standing long jump (SLJ), hop test (HT), 10 m sprint (10 m), 10 × 5 m shuttle run test (SRT), and leg raise test (LR). The DEA group showed significantly higher results in the SLJ (p < 0.001), HT left leg (p < 0.001), 10 m sprint (p < 0.001), and SRT (p < 0.001). In conclusion, the dynamic–ecological approach provides higher performance adaptations. Therefore, this approach can be considered a suitable method to optimise pre-pubertal player training, mainly when no fitness or strength coach is available. Full article
(This article belongs to the Section Athletic Training and Human Performance)
17 pages, 1576 KiB  
Review
The Preventive Role of Glutamine Supplementation in Cardiac Surgery-Associated Kidney Injury from Experimental Research to Clinical Practice: A Narrative Review
by Anca Drăgan and Adrian Ştefan Drăgan
Medicina 2024, 60(5), 761; https://doi.org/10.3390/medicina60050761 (registering DOI) - 03 May 2024
Abstract
Acute kidney injury represents a significant threat in cardiac surgery regarding complications and costs. Novel preventive approaches are needed, as the therapeutic modalities are still limited. As experimental studies have demonstrated, glutamine, a conditionally essential amino acid, might have a protective role in [...] Read more.
Acute kidney injury represents a significant threat in cardiac surgery regarding complications and costs. Novel preventive approaches are needed, as the therapeutic modalities are still limited. As experimental studies have demonstrated, glutamine, a conditionally essential amino acid, might have a protective role in this setting. Moreover, the levels of glutamine after the cardiopulmonary bypass are significantly lower. In clinical practice, various trials have investigated the effects of glutamine supplementation on cardiac surgery with encouraging results. However, these studies are heterogeneous regarding the selection criteria, timing, dose, outcomes studied, and way of glutamine administration. This narrative review aims to present the potential role of glutamine in cardiac surgery-associated acute kidney injury prevention, starting from the experimental studies and guidelines to the clinical practice and future directions. Full article
(This article belongs to the Collection Interdisciplinary Medicine – The Key For Personalized Medicine)
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22 pages, 10574 KiB  
Article
Rats Orally Administered with Ethyl Alcohol for a Prolonged Time Show Histopathology of the Epididymis and Seminal Vesicle Together with Changes in the Luminal Metabolite Composition
by Chayakorn Taoto, Nareelak Tangsrisakda, Wipawee Thukhammee, Jutarop Phetcharaburanin, Sitthichai Iamsaard and Nongnuj Tanphaichitr
Biomedicines 2024, 12(5), 1010; https://doi.org/10.3390/biomedicines12051010 (registering DOI) - 03 May 2024
Abstract
Prolonged ethanol (EtOH) consumption is associated with male infertility, with a decreased spermatogenesis rate as one cause. The defective maturation and development of sperm during their storage in the cauda epididymis and transit in the seminal vesicle can be another cause, possibly occurring [...] Read more.
Prolonged ethanol (EtOH) consumption is associated with male infertility, with a decreased spermatogenesis rate as one cause. The defective maturation and development of sperm during their storage in the cauda epididymis and transit in the seminal vesicle can be another cause, possibly occurring before the drastic spermatogenesis disruption. Herein, we demonstrated that the cauda epididymis and seminal vesicle of rats, orally administered with EtOH under a regimen in which spermatogenesis was still ongoing, showed histological damage, including lesions, a decreased height of the epithelial cells and increased collagen fibers in the muscle layer, which implicated fibrosis. Lipid peroxidation (shown by malondialdehyde (MDA) levels) was observed, indicating that reactive oxygen species (ROS) were produced along with acetaldehyde during EtOH metabolism by CYP2E1. MDA, acetaldehyde and other lipid peroxidation products could further damage cellular components of the cauda epididymis and seminal vesicle, and this was supported by increased apoptosis (shown by a TUNEL assay and caspase 9/caspase 3 expression) in these two tissues of EtOH-treated rats. Consequently, the functionality of the cauda epididymis and seminal vesicle in EtOH-treated rats was impaired, as demonstrated by a decreases in 1H NMR-analyzed metabolites (e.g., carnitine, fructose), which were important for sperm development, metabolism and survival in their lumen. Full article
(This article belongs to the Special Issue Molecular Regulation of Spermatozoa)
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15 pages, 2439 KiB  
Article
Assessment of Anti-Prostate Cancer Activity among Four Seaweeds, with Focus on Caulerpa lentillifera J.Agardh
by Guan-James Wu and Pei-Wen Hsiao
Foods 2024, 13(9), 1411; https://doi.org/10.3390/foods13091411 (registering DOI) - 03 May 2024
Abstract
In response to a global shift towards health-conscious and environmentally sustainable food choices, seaweed has emerged as a focus for researchers due to its large-scale cultivation potential and the development of bioactive substances. This research explores the potential anticancer properties of seaweed extracts, [...] Read more.
In response to a global shift towards health-conscious and environmentally sustainable food choices, seaweed has emerged as a focus for researchers due to its large-scale cultivation potential and the development of bioactive substances. This research explores the potential anticancer properties of seaweed extracts, focusing on analyzing the impact of four common edible seaweeds in Taiwan on prostate cancer (PCa) cells’ activity. The study used bioassay-guided fractionation to extract Cl80 from various seaweeds with androgen receptor (AR)-inhibitory activity. Cl80 demonstrated effective suppression of 5α-dihydrotestosterone (DHT)-induced AR activity in 103E cells and attenuated the growth and prostate-specific antigen (PSA) protein expression in LNCaP and 22Rv1 cells. Additionally, Cl80 exhibited differential effects on various PCa cell lines. Concentrations above 5 μg/mL significantly inhibited LNCaP cell proliferation, while 22Rv1 cells were more resistant to Cl80. PC-3 cell proliferation was inhibited at 5 μg/mL but not completely at 50 μg/mL. A clonogenic assay showed that at a concentration of 0.5 μg/mL, the colony formation in LNCaP and PC-3 cells was significantly reduced, with a dose-dependent effect. Cl80 induced apoptosis in all PCa cell types, especially in LNCaP cells, with increased apoptotic cells observed at higher concentrations. Cl80 also decreased the mitochondrial membrane potential (ΔΨm) in a dose-dependent manner in all PCa cell lines. Furthermore, Cl80 suppressed the migration ability of PCa cells, with significant reductions observed in LNCaP, 22Rv1, and PC-3 cells at various concentrations. These compelling findings highlight the promising therapeutic potential of C. lentillifera J.Agardh and its isolated compound Cl80 in the treatment of PCa. Full article
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25 pages, 19602 KiB  
Article
Real-Time EtherCAT-Based Control Architecture for Electro-Hydraulic Humanoid
by Maysoon Ghandour, Subhi Jleilaty, Naima Ait Oufroukh, Serban Olaru and Samer Alfayad
Mathematics 2024, 12(9), 1405; https://doi.org/10.3390/math12091405 (registering DOI) - 03 May 2024
Abstract
Electro-hydraulic actuators have witnessed significant development over recent years due to their remarkable abilities to perform complex and dynamic movements. Integrating such an actuator in humanoids is highly beneficial, leading to a humanoid capable of performing complex tasks requiring high force. This highlights [...] Read more.
Electro-hydraulic actuators have witnessed significant development over recent years due to their remarkable abilities to perform complex and dynamic movements. Integrating such an actuator in humanoids is highly beneficial, leading to a humanoid capable of performing complex tasks requiring high force. This highlights the importance of safety, especially since high power output and safe interaction seem to be contradictory; the greater the robot’s ability to generate high dynamic movements, the more difficult it is to achieve safety, as this requires managing a large amount of motor energy before, during, and after the collision. No matter what technology or algorithm is used to achieve safety, none can be implemented without a stable control system. Hence, one of the main parameters remains the quality and reliability of the robot’s control architecture through handling a huge amount of data without system failure. This paper addresses the development of a stable control architecture that ensures, in later stages, that the safety algorithm is implemented correctly. The optimum control architecture to utilize and ensure the maximum benefit of electro-hydraulic actuators in humanoid robots is one of the important subjects in this field. For a stable and safe functioning of the humanoid, the development of the control architecture and the communication between the different components should adhere to some requirements such as stability, robustness, speed, and reduced complexity, ensuring the easy addition of numerous components. This paper presents the developed control architecture for an underdeveloped electro-hydraulic actuated humanoid. The proposed solution has the advantage of being a distributed, real-time, open-source, modular, and adaptable control architecture, enabling simple integration of numerous sensors and actuators to emulate human actions and safely interact with them. The contribution of this paper is an enhancement of the updated rate compared to other humanoids by 20% and by 40 % in the latency of the master. The results demonstrate the potential of using EtherCAT fieldbus and open-source software to develop a stable robot control architecture capable of integrating safety and security algorithms in later stages. Full article
(This article belongs to the Special Issue Dynamic Modeling and Simulation for Control Systems, 2nd Edition)
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19 pages, 635 KiB  
Review
Circulating Biomarkers in Pulmonary Arterial Hypertension: An Update
by Michele Correale, Lucia Tricarico, Ester Maria Lucia Bevere, Francesco Chirivì, Francesca Croella, Paolo Severino, Valentina Mercurio, Damiano Magrì, Frank Dini, Roberto Licordari, Matteo Beltrami, Giuseppe Dattilo, Andrea Salzano and Alberto Palazzuoli
Biomolecules 2024, 14(5), 552; https://doi.org/10.3390/biom14050552 (registering DOI) - 03 May 2024
Abstract
Pulmonary arterial hypertension (PAH) is a rare subtype of group 1 pulmonary hypertension (PH) diseases, characterized by high pulmonary artery pressure leading to right ventricular dysfunction and potential life-threatening consequences. PAH involves complex mechanisms: vasoconstriction, vascular remodeling, endothelial dysfunction, inflammation, oxidative stress, fibrosis, [...] Read more.
Pulmonary arterial hypertension (PAH) is a rare subtype of group 1 pulmonary hypertension (PH) diseases, characterized by high pulmonary artery pressure leading to right ventricular dysfunction and potential life-threatening consequences. PAH involves complex mechanisms: vasoconstriction, vascular remodeling, endothelial dysfunction, inflammation, oxidative stress, fibrosis, RV remodeling, cellular hypoxia, metabolic imbalance, and thrombosis. These mechanisms are mediated by several pathways, involving molecules like nitric oxide and prostacyclin. PAH diagnosis requires clinical evaluation and right heart catheterization, confirming a value of mPAP ≥ 20 mmHg at rest and often elevated pulmonary vascular resistance (PVR). Even if an early and accurate diagnosis is crucial, PAH still lacks effective biomarkers to assist in its diagnosis and prognosis. Biomarkers could contribute to arousing clinical suspicion and serve for prognosis prediction, risk stratification, and dynamic monitoring in patients with PAH. The aim of the present review is to report the main novelties on new possible biomarkers for the diagnosis, prognosis, and treatment monitoring of PAH. Full article
(This article belongs to the Special Issue Molecular Biomarkers In Cardiology 2022–2023)
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16 pages, 12496 KiB  
Article
Enhanced Surface Properties of TiO2-Based Coatings via Stevia-Assisted Spark Suppression: Insights from Density Functional Theory Calculations
by Mosab Kaseem, Ananda Repycha Safira and Arash Fattah-alhosseini
Inorganics 2024, 12(5), 134; https://doi.org/10.3390/inorganics12050134 (registering DOI) - 03 May 2024
Abstract
This study investigates the enhancement of surface properties in TiO2-based coatings on the Ti-6Al-4V alloy through micro-arc oxidation (MAO), employing stevia sugar as a novel additive. By incorporating stevia sugar into acetate–glycerophosphate–tetraethoxysilane solutions used in MAO treatment, the porous morphology of [...] Read more.
This study investigates the enhancement of surface properties in TiO2-based coatings on the Ti-6Al-4V alloy through micro-arc oxidation (MAO), employing stevia sugar as a novel additive. By incorporating stevia sugar into acetate–glycerophosphate–tetraethoxysilane solutions used in MAO treatment, the porous morphology of TiO2-based oxide layers is regulated. The incorporation of stevia moderates plasma discharge intensity, facilitating the formation of a uniform silicon-rich structure characterized by reduced porosity and pore size. This effect is attributed to the interaction between stevia and tetraethyl orthosilicate (TEOS), which modifies the TEOS hydrolysis process, thereby enhancing structural uniformity and stability while concurrently reducing plasma discharge intensity. Additionally, theoretical calculations offer a valuable understanding of the reactivity and interactions of stevia, TEOS, and their complex during the MAO process, laying the groundwork for further research and optimization in this promising field. Full article
(This article belongs to the Section Inorganic Materials)
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15 pages, 549 KiB  
Article
Fearlessness as an Underlying Mechanism Leading to Conduct Problems: Testing the INTERFEAR Model in a Community Sample in Spain
by Kostas A. Fanti, Ioannis Mavrommatis, Beatriz Díaz-Vázquez, Laura López-Romero, Estrella Romero, María Álvarez-Voces, Olivier F. Colins, Henrik Andershed and Nicholas Thomson
Children 2024, 11(5), 546; https://doi.org/10.3390/children11050546 (registering DOI) - 03 May 2024
Abstract
Conduct problems (CP) in childhood and adolescence have a significant impact on the individual, family, and community. To improve treatment for CP, there is a need to improve the understanding of the developmental pathways leading to CP in boys and girls. Prior research [...] Read more.
Conduct problems (CP) in childhood and adolescence have a significant impact on the individual, family, and community. To improve treatment for CP, there is a need to improve the understanding of the developmental pathways leading to CP in boys and girls. Prior research has linked the child’s fearlessness and callous–unemotional (CU) traits, as well as experiences of parental warmth and punitive parenting, to CP. However, few studies have tested the interplay of these factors in contributing to future CP development. The present study aimed to test the InterFear model, which suggests that fearlessness in early childhood leads to CP through an indirect pathway involving low positive parenting, high negative/punitive parenting, and callous–unemotional (CU) traits. The sample included 2467 Spanish children (48.1% girls; Mage = 4.25; SD = 0.91), followed up across a five-year period. Besides a direct association between fearlessness in early childhood and future CP, the results found an indirect pathway whereby fearlessness reduces positive parenting and increases punitive parenting, which contributes to the development of CU traits and sets the stage for CP in later childhood. The specific indirect effect from fearlessness to CP via CU traits accounted for most of the variance, suggesting the existence of a temperamental pathway independent of parental variables. Further, two additional indirect pathways, exclusive of fearlessness, were identified, which started with low parental warmth and positive parenting, leading to CP via CU traits. These findings support the InterFear model, demonstrating multiple pathways to CP with the involvement of fearlessness, parenting practices, and CU traits. This model might play a pivotal role in the development of targeted prevention and intervention strategies for CP. Full article
(This article belongs to the Section Child and Adolescent Psychiatry)
14 pages, 12042 KiB  
Article
Tightly Trapped Atom Interferometer inside a Hollow-Core Fiber
by Yitong Song, Wei Li, Xiaobin Xu, Rui Han, Chengchun Gao, Cheng Dai and Ningfang Song
Photonics 2024, 11(5), 428; https://doi.org/10.3390/photonics11050428 (registering DOI) - 03 May 2024
Abstract
We demonstrate a fiber-guided atom interferometer in a far-off-resonant trap (FORT) of 100 μK. The differential light shift (DLS) introduced by the FORT leads to the inhomogeneous dephasing of the tightly trapped atoms inside a hollow-core fiber. The DLS-induced dephasing is greatly suppressed [...] Read more.
We demonstrate a fiber-guided atom interferometer in a far-off-resonant trap (FORT) of 100 μK. The differential light shift (DLS) introduced by the FORT leads to the inhomogeneous dephasing of the tightly trapped atoms inside a hollow-core fiber. The DLS-induced dephasing is greatly suppressed in π/2-π-π/2 Doppler-insensitive interferometry. The spin coherence time is extended to 13.4 ms by optimizing the coupling of the trapping laser beam into a quasi-single-mode hollow-core anti-resonant fiber. The Doppler-sensitive interferometry shows a much shorter coherence time, indicating that the main limits to our fiber-guided atom interferometer are the wide axial velocity distribution and the irregular modes of the Raman laser beams inside the fiber. This work paves the way for portable and miniaturized quantum devices, which have advantages for inertial sensing at arbitrary orientations and in dynamic environments. Full article
(This article belongs to the Special Issue The Integration of Quantum Communication and Quantum Sensors)
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12 pages, 2756 KiB  
Article
Polarization Diffraction Gratings in PAZO Polymer Thin Films Recorded with Digital Polarization Holography: Polarization Properties and Surface Relief Formation
by Nataliya Berberova-Buhova, Lian Nedelchev, Georgi Mateev, Ludmila Nikolova, Elena Stoykova, Branimir Ivanov, Velichka Strijkova, Keehoon Hong and Dimana Nazarova
Photonics 2024, 11(5), 425; https://doi.org/10.3390/photonics11050425 (registering DOI) - 03 May 2024
Abstract
In this work, we study the polarization properties of diffraction gratings recorded in thin films of the azopolymer PAZO (poly[1-[4-(3-carboxy-4-hydroxyphenylazo)benzene sulfonamido]-1,2-ethanediyl, sodium salt]) using digital polarization holography. Using two quarter-wave plates, the phase retardation of each pixel of the SLM is converted into [...] Read more.
In this work, we study the polarization properties of diffraction gratings recorded in thin films of the azopolymer PAZO (poly[1-[4-(3-carboxy-4-hydroxyphenylazo)benzene sulfonamido]-1,2-ethanediyl, sodium salt]) using digital polarization holography. Using two quarter-wave plates, the phase retardation of each pixel of the SLM is converted into the azimuth rotation of linearly polarized light. When recording from the azopolymer side of the sample, significant surface relief amplitude is observed with atomic force microscopy. In contrast, recording from the substrate side of the sample allows the reduction of the surface relief modulation and the obtaining of polarization gratings with characteristics close to an ideal grating, recorded with two orthogonal circular polarizations. This can be achieved even with a four-pixel period of grating, as demonstrated by our results. Full article
(This article belongs to the Special Issue Technologies and Applications of Digital Holography)
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