A grammatical construction resembling Present-Day English locative inversion has already been found in Old English, with a fronted prepositional phrase prompting V2 word order, both in main and subordinate clauses. It has been demonstrated that several discourse-related factors influence the positioning of objects, fronted locatives, finite verbs and subjects in subordinate clauses. One of the main aims of the present paper is to provide a quantitative and qualitative analysis of the locative inversion construction in Old English subordinate clauses. The Old English data for this study were obtained from the York–Toronto–Helsinki Parsed Corpus of Old English Prose, and they were analysed using Corpus Studio. The results were compared with those for main clauses, and discourse-related factors such as PP anaphoricity or subject type were analysed in order to find the motivation for the existence of this alternation of word orders. PP anaphoricity proved not to be a determining factor in triggering finite verb inversion, while other factors such as subject weight and subject type do seem to motivate finite verb inversion, thus yielding an embedded PP-V-S word order. Full article

Background: Appendiceal neuroendocrine tumors (NETs) rank as the third most frequent neoplasm affecting the appendix, originating from enterochromaffin cells. This study aims to evaluate the influence of various prognostic factors on the mortality rates of patients diagnosed with NETs of the appendix. Methods: Conducted retrospectively, the study involved 3346 patients, utilizing data sourced from the Surveillance, Epidemiology, and End Results (SEER) database. Our analysis centered on investigating demographic characteristics, clinical features, overall mortality (OM), and cancer-specific mortality (CSM) among the cohort. Variables showing a p-value < 0.1 in the univariate Cox regression were incorporated into the multivariate Cox regression analysis. A Hazard Ratio (HR) > 1 indicated an unfavorable prognosis. Results: In the multivariate analysis, higher OM and CSM were observed in males, older age groups, tumors with distant metastasis, poorly differentiated tumors, and those who underwent chemotherapy. Non-Hispanic Black individuals showed elevated mortality rates. Conclusion: Delayed diagnosis may contribute to the increased mortality in this community. Improved access to healthcare and treatment is crucial for addressing these disparities. Larger prospective studies are needed to pinpoint the underlying causes of elevated mortality in non-Hispanic Black populations, and randomized controlled trials (RCTs) are warranted to evaluate therapies for advanced-stage appendix NETs. Full article

Spatial planning, a policy instrument for creating sustainable environments that meet the needs of the current and future generations, has been implemented extensively worldwide. However, it is difficult for urban planners to thoroughly determine the spatial value of a territory and make informed decisions regarding the efficient utilization of regional resources in the real world. This study proposes a novel methodological framework for spatial pattern optimization that can guide future land use by integrating Minimum Spanning Tree (MST) clustering with a comprehensive evaluation system (dual evaluation). Furthermore, the validity of this framework is demonstrated through a case study of territorial spatial planning in Deyang, China. The findings indicate that (1) the methodological framework presented in this study offers valuable guidance for the spatial arrangement of territorial resources, especially in practical projects; and (2) the combination of dual evaluation and MST clustering can facilitate automatic regionalization to identify spatial clusters exhibiting functional similarity in terms of land use. By focusing on methodological advancements, this study concludes that the integration of dual evaluation (DE) and MST clustering not only simplifies the identification of optimal land-use patterns but also promotes a more systematic and efficient approach to support spatial planning. Full article

HBV infection is challenging to cure due to the persistence of viral covalently closed circular viral DNA (cccDNA). The dedicator of cytokinesis 11 (DOCK11) is recognized as a guanine nucleotide exchange factor (GEF) for CDC42 that has been reported to be required for HBV persistence. DOCK11 is expressed in both the cytoplasm and nucleus of human hepatocytes and is functionally associated with retrograde trafficking proteins Arf-GAP with GTPase domain, ankyrin repeat, and pleckstrin homology domain-containing protein 2 (AGAP2), and ADP-ribosylation factor 1 (ARF1), together with the HBV capsid, in the trans-Golgi network (TGN). This opens an alternative retrograde trafficking route for HBV from early endosomes (EEs) to the TGN and then to the endoplasmic reticulum (ER), thereby avoiding lysosomal degradation. DOCK11 also facilitates the association of cccDNA with H3K4me3 and RNA Pol II for activating cccDNA transcription. In addition, DOCK11 plays a crucial role in the host DNA repair system, being essential for cccDNA synthesis. This function can be inhibited by 10M-D42AN, a novel DOCK11-binding peptide, leading to the suppression of HBV replication both in vitro and in vivo. Treatment with a combination of 10M-D42AN and entecavir may represent a promising therapeutic strategy for patients with chronic hepatitis B (CHB). Consequently, DOCK11 may be seen as a potential candidate molecule in the development of molecularly targeted drugs against CHB. Full article

This study examines fiscal sustainability in Latin American countries from a unique time–frequency perspective, focusing on Brazil, Chile, Colombia, Peru, and Mexico from 1997 to 2022. Using wavelet coherence analysis, it uncovers dynamic relationships between government revenue and expenditure over different time horizons, revealing varying causality patterns across countries and periods. The findings underscore the importance of balanced fiscal planning and resource allocation to ensure fiscal sustainability and support economic growth. This research contributes to a deeper understanding of Latin America’s economic landscape and provides valuable insights for policymakers, economists, and stakeholders concerned with the region’s economic stability and development. Full article

Over the last two decades, the invasiveness of thoracic surgery has decreased along with technological advances and better diagnostic tools, whereas the patient’s comorbidities and frailty patterns have increased, as well as the number of early cancer stages that could benefit from curative resection. Poor aerobic fitness, nutritional defects, sarcopenia and “toxic” behaviors such as sedentary behavior, smoking and alcohol consumption are modifiable risk factors for major postoperative complications. The process of enhancing patients’ physiological reserve in anticipation for surgery is referred to as prehabilitation. Components of prehabilitation programs include optimization of medical treatment, prescription of structured exercise program, correction of nutritional deficits and patient’s education to adopt healthier behaviors. All patients may benefit from prehabilitation, which is part of the enhanced recovery after surgery (ERAS) programs. Faster functional recovery is expected in low-risk patients, whereas better clinical outcome and shorter hospital stay have been demonstrated in higher risk and physically unfit patients. Full article

An efficient and accurate estimation of wheat growth and yield is important for wheat assessment and field management. To improve the accuracy and stability of wheat growth and yield estimation, an estimation method based on a genetic algorithm-improved support vector regression (GA-SVR) algorithm was proposed in this study. The correlation analysis between vegetation indices calculated from spectral data and wheat growth phenotypes and yields was performed to obtain the optimal combination of vegetation indices with high correlation and good estimation performance. At the same time, the optimal model for wheat growth monitoring was screened and constructed in experiments with 12 wheat varieties and 3 gradient nitrogen fertilizer application levels. Then, the yield estimation model was established and its applicability was verified under different nitrogen fertilizer application levels. The results showed that the constructed models for the leaf area index, plant height, and yield estimation performed well, with coefficients of determination of 0.82, 0.71, and 0.70, and root mean square errors of 0.09, 2.7, and 68.5, respectively. This study provided an effective UAV remote sensing technique for monitoring wheat growth status and estimating yield. This study provides an effective unmanned aerial remote sensing technique for monitoring wheat growth and estimating yield, and provides technical support for wheat yield assessment and field management. Full article

A three-degree-of-freedom (3-DOF) piezoelectric ultrasonic transducer is a critical component in elliptical and longitudinal ultrasonic vibration-assisted cutting processes, with its geometric structure directly influencing its performance. This paper proposes a structural optimization method based on a convolutional neural network (CNN) and non-dominated sorting genetic algorithm II (NSGA2). This method establishes a transducer lumped model to obtain the electromechanical coupling coefficients (X-$k_e$ and Z-$k_e$) and thermal power (X-P) indicators, evaluating the bending and longitudinal vibration performance of the transducer. By creating a finite element model of the transducer with mechanical losses, a dataset of different transducer performance parameters, including the tail mass, piezoelectric stack, and dimensions of the horn, is obtained. Training a CNN model with this dataset yields objective functions for the relationship between different transducer geometric structures and performance parameters. The NSGA2 algorithm solves the X-$k_e$ and Z-$k_e$ objective functions, obtaining the Pareto set of the transducer geometric dimensions and determining the optimal transducer geometry in conjunction with X-P. This method achieves simultaneous improvements in X-$k_e$ and Z-$k_e$ of the transducer by 22.33% and 25.89% post-optimization and reduces X-P to 18.97 W. Furthermore, the finite element simulation experiments of the transducer validate the effectiveness of this method. Full article

A link between bisphenol A (BPA) exposure and cognitive disorders has been suggested. However, the differences in BPA concentrations between subjects with and without cognitive impairment have not been analysed. Therefore, this observational study aimed to compare urine BPA levels in subjects with normal cognitive function (NCF) and mild cognitive impairment (MCI). A total of 89 MCI subjects and 89 well-matched NCF individuals were included in this study. Cognitive functions were assessed using the Montreal Cognitive Assessment (MOCA) scale. Urine BPA concentrations were evaluated by gas chromatography–mass spectrometry and adjusted for creatinine levels. Moreover, anthropometric parameters, body composition, sociodemographic factors, and physical activity were also assessed. Creatinine-adjusted urine BPA levels did not differ between the NCF and MCI groups (1.8 (1.4–2.7) vs. 2.2 (1.4–3.6) µg/g creatinine, p = 0.1528). However, there were significant differences in MOCA results between groups when the study population was divided into tertiles according to BPA concentrations (p = 0.0325). Nevertheless, multivariate logistic regression demonstrated that only education levels were independently associated with MCI. In conclusion, urine BPA levels are not significantly different between subjects with MCI and NCF, but these findings need to be confirmed in further studies. Full article

In recent years, the intensity and frequency of droughts have been increasing with the advent of the climate crisis. Agricultural droughts have a significant economic and social impact. Agricultural drought is not only a natural disaster but also leads to food security threats and reduced economic activities, such as decreased productivity. Therefore, it is very important to specify the scale of agricultural drought and quantitatively estimate the economic damage. In this study, we developed an analytical methodology to quantitatively assess the economic damage of agricultural drought and estimated the damage of agricultural drought in 2018 and 2019 for the Republic of Korea. The 2018 agricultural drought was estimated to have caused USD 4.438 million in damage cost and USD 5.180 million in recovery cost. The 2019 drought was less damaging than the previous year, with an estimated damage cost of USD 286,000 and recovery costs of USD 218,000. The results suggest that the economic impact of agricultural drought varies by region depending on the frequency and intensity of the drought and confirm the importance of regional strategies for effective drought management and response. The impacts of agricultural drought go beyond short-term agricultural losses and lead to long-term economic burdens. Therefore, the results of this study are expected to be used as a basis for understanding the impacts of agricultural drought on national economies and for developing policies and strategies to minimize impacts. Full article

Background: Postoperative de novo atrial fibrillation (POAF) is one of the most frequently encountered complications following cardiac surgery. Despite the identification of several risk factors, the link between sleep-disordered breathing (SDB) and POAF has barely been examined. The objective of this prospective observational study was to determine whether severe SDB is associated with POAF in patients after elective coronary artery bypass grafting (CABG) surgery. Study design and methods: The incidence and preoperative predictors of in-hospital POAF were assessed in 272 patients undergoing CABG surgery at the University Medical Center Regensburg (Germany). In-hospital POAF was detected by continuous telemetry-ECG monitoring and 12-lead resting ECGs within the first seven postoperative days. POAF that occurred after hospital discharge within 60 days post CABG surgery was classified as post-hospital POAF and was ascertained by standardized phone interviews together with the patients’ medical files, including routinely performed Holter-ECG monitoring at 60 days post CABG surgery. The night before surgery, portable SDB monitoring was used to assess the presence and type of severe SDB, defined by an apnea–hypopnea index ≥ 30/h. Results: The incidence of in-hospital POAF was significantly higher in patients with severe SDB compared to those without severe SDB (30% vs. 15%, p = 0.009). Patients with severe SDB suffered significantly more often from POAF at 60 days post CABG surgery compared to patients without severe SDB (14% vs. 5%, p = 0.042). Multivariable logistic regression analysis showed that severe SDB (odds ratio, OR [95% confidence interval, CI]: 2.23 [1.08; 4.61], p = 0.030), age ≥ 65 years (2.17 [1.04; 4.53], p = 0.038), and diabetes mellitus (2.27 [1.15; 4.48], p = 0.018) were significantly associated with in-hospital POAF. After additional adjustment for heart failure, the association between sleep apnea and postoperative atrial fibrillation was attenuated (1.99 [0.92; 4.31], p = 0.081). Conclusions: Amongst established risk factors, severe SDB was significantly associated with in-hospital POAF in patients undergoing CABG surgery. Whether SDB contributes to POAF independently of heart failure and whether risk for POAF may be alleviated by proper treatment of SDB merits further investigation. Full article

As companies increasingly undergo digital transformation, the role of talent management processes becomes pivotal in enhancing overall organizational performance. The objective of this research is to assess the extent to which greater digitalization in the talent management process is linked to company size. The research has addressed four research questions in order to explore the significance of talent management in corporate digital transformation, examining whether variations in the digitalization of these processes can be attributed to company size. A qualitative approach was employed, utilizing a questionnaire, and collecting responses from 202 organizations across diverse sectors. The findings reveal disparities in digitalization throughout the talent management process, with pronounced presence in the attracting, selecting, and rewarding phases, but diminishing in deployment and development, and further declining in planning. A positive correlation between company size and the adoption of specific digital platforms was observed. Larger enterprises exhibit greater utilization of digital platforms in talent deployment and development. Moreover, corporate communication tools are consistently utilized in the rewarding phase, irrespective of company size. These findings offer practical insights for organizations aiming to optimize their digitalization strategies based on their scale, thereby contributing to more effective and tailored digitalization endeavours. The uniqueness of this research lies in its exploration of the influence of company size on the digitalization of talent management processes and its potential to explain variations across different stages of these processes. Full article

Bicyclic peptides have attracted the interest of pharmaceutical companies because of their remarkable properties, putting them on a new path in medicine. Their conformational rigidity improves proteolytic stability and leads to rapid penetration into tissues via any possible route of administration. Moreover, elimination of renal metabolism is of great importance, for example, for people with a history of liver diseases. In addition, each ring can function independently, making bicyclic peptides extremely versatile molecules for further optimization. In this paper, we compared the potentiometric and spectroscopic properties studied by UV–vis, MCD, and EPR of four synthetic analogues of the bi-cyclic peptide c(PKKHP-c(CFWKTC)-PKKH) (BCL). In particular, we correlated the structural and spectral properties of complexes with coordinating abilities toward Cu(II) ions of MCL1 (Ac-PKKHPc(CFWKTC)PKKH-NH₂) that contains the unbinding cycle and N- and C-terminal linear parts with two histidine residues, one per part; two monocyclic ligands containing one histidine residue, both in the N-terminal position, i.e., MCL2 (Ac-PKKHPc(CFWKTC)PKKS-NH₂) and in the C-terminal position, i.e., MCL3 (Ac-PKKSPc(CFWKTC)PKKH-NH₂), respectively; and the linear structure LNL (Ac-PKKHPSFWKTSPKKH-NH₂). Potentiometric results have shown that the bicyclic structure promotes the involvement of the side chain imidazole donors in Cu(II) binding. On the other hand, the results obtained for the mono-cyclic analogues lead to the conclusion that the coordination of the histidine moiety as an anchoring group is promoted by its location in the peptide sequence further from the nonbinding cycle, strongly influencing the involvement of the amide donors in Cu(II) coordination. Full article

The application of superamphiphobic coatings improves the surface’s ability to repel fluids, thereby greatly enhancing its various functions, including anti-fouling, anti-corrosion, anti-icing, anti-bacterial, and self-cleaning properties. This maximizes the material’s potential for industrial applications. This work utilized the agglomeration phenomenon exhibited by nano-spherical titanium dioxide (TiO₂) particles to fabricate 1H,1H,2H,2H-perfluorodecyltriethoxysilane (PFDTES) modified TiO₂ (TiO₂@fluoroPOS) fillers with low surface energy. This was achieved through the in-situ formation of protective armor on the surface of the agglomerates using the sol-gel method and fluorination modification. Polyvinylidene fluoride-tetrafluoropropylene (PVDF-HFP) and TiO₂@fluoroPOS fillers were combined using a spraying technique to prepare P/TiO₂@fluoroPOS coatings with superamphiphobicity. Relying on the abundance of papillae, micropores, and other tiny spaces on the surface, the coating can capture a stable air film and reject a variety of liquids. When the coatings were immersed in solutions of 2 mol/L HCl, NaCl, and NaOH for a duration of 12 h, they retained their exceptional superamphiphobic properties. Owing to the combined influence of the armor structure and the organic binder, the coating exhibited good liquid repellency during water jetting and sandpaper abrasion tests. Furthermore, the coating has shown exceptional efficacy in terms of its ability to be anti-icing, anti-waxing, and self-cleaning. Full article

The article analyses knowledge control and evaluation methods in higher education, focusing on both standardized and non-standardized testing. It explores fundamental quality criteria and the perspectives of lecturers and students on the roles of these methods in assessing knowledge. The study evaluates attitudes towards both testing types, considering factors such as efficiency, usability, reliability, objectivity, accuracy, and content relevance. The findings suggest that combining standardized and non-standardized tests with problem-solving tasks significantly enhances knowledge assessment in technical disciplines, demonstrating the methods’ interdependence and complementarity. Data shows that both testing types achieve high scores, with standardized tests receiving an integral index of 0.72 and non-standardized tests scoring 0.69. Respondents positively evaluate the effectiveness and convenience of standardized tests, attributing their reliability, objectivity, accuracy, and practical orientation. Although there is a clear preference for standardized tests among participants, the benefits of non-standardized tests are also acknowledged. The study thus recommends a balanced approach, incorporating both methods to ensure an effective and high-quality assessment and knowledge control strategy in higher education. Full article

Among the methods of 3D reconstruction, the automatic generation of 3D models from building documentation is one of the most accessible and inexpensive. For 30 years, researchers have proposed multiple methods to automatically generate 3D models from 2D drawings. This study compiles this research and discusses the different methods used to generate 3D models from 2D drawings. It offers a critical review of these methods, focusing on the coverage and completeness of the reconstruction process. This review allows us to identify the research gaps in the literature, and opportunities for improvement are identified for future research. Full article

Considering the Friedmann–Lemaître–Robertson–Walker (FLRW) metric and the Einstein scalar field system as an underlying gravitational model to construct fractional cosmological models has interesting implications in both classical and quantum regimes. Regarding the former, we just review the most fundamental approach to establishing an extended cosmological model. We demonstrate that employing new methodologies allows us to obtain exact solutions. Despite the corresponding standard models, we cannot use any arbitrary scalar potentials; instead, it is determined from solving three independent fractional field equations. This article concludes with an overview of a fractional quantum/semi-classical model that provides an inflationary scenario. Full article

Background and Objectives: Cellulite, or edemato-fibro-sclerotic panniculopathy (EFP), is characterized by dermal and hypodermal changes leading to adipose tissue accumulation and compromised venous circulation. This study investigates the efficacy of a hypertonic cream containing concentrated sodium chloride (Jovita Osmocell^®) in addressing water retention and structural alterations in adipose tissue, aiming to interrupt the cellulite formation process. Materials and Methods: A 12-week, prospective, monocentric, double-blind, placebo-controlled study enrolled 30 female subjects with grade II or III cellulite. Patients were randomized to receive hypertonic cream or a placebo. Thigh circumference, ultrasound evaluations, and standardized photographs were collected at baseline, intermediate, and endpoint visits. Adverse events were monitored. Results: After 84 days, the hypertonic cream group exhibited a significant reduction in thigh circumference compared to the placebo group (p = 0.0037). B-mode ultrasound examinations revealed significant changes in the parameters studied, such as the thickness of the subcutaneous tissue. No statistically significant changes were noticed in the placebo group. Volunteers reported the investigational product’s pleasantness and good anti-cellulite activity, with no reported adverse events. Conclusions: The hypertonic cream demonstrated efficacy in reducing thigh circumference, addressing water retention and structural alterations in adipose tissue. The proposed mechanism involves osmosis, releasing accumulated fluids between fat cells, supporting drainage, and reducing inflammation. This study supports the efficacy and safety of hypertonic sodium chloride emulsions in cellulite treatment and confirms safety and user satisfaction. Full article

In the cement concrete manufacturing industry, mixers are critical pieces of equipment that play an essential role. Mixers ensure, by mechanically mixing the materials that make up the concrete, the homogeneity of the mixture. Since the active elements of the mixer in the concrete industry—the mixing blades—come into permanent contact with the mineral aggregates in the mixture formed by water and cement, they are permanently subjected to a strong abrasive–erosive wear process. The authors of this article were concerned with the establishment of tribological models for studying the wear of mixing blades, in order to identify the influence of their constructive parameters on the wear intensity. A complex model (Kraghelsky–Nepomnyashchi model) was adopted for the study. The modeling results revealed that the wear intensity decreases with an increasing blade angle of attack and increases linearly with increasing speed, as well as with an increasing friction coefficient. The modeling results confirm that the wear intensity is lowest when the mixing blade is inclined at a 60° angle, while the highest value is recorded for 30°. By identifying the angle at which the greatest wear of blades occurs, interventions can be made in the design of a more durable mixer (with the optimal installation angle of the mixer blades), thus requiring fewer corrective maintenance interventions. Based on these findings, we conclude that the complex model used in the experiment can provide a convenient and efficient tool for the study of erosive–abrasive phenomena. Full article

We present existing results and properties for the solutions of some vector equilibrium problems with set-valued functions in the case of a vector space ordered by a cone with some “interiority” properties. Some applications concerning the existence of equilibrium for abstract economies and vector optimization problems are given. Full article

(1) Background: A simple approach to map irrigated landcover has been introduced by using measures derived from the optical spectral range as an alternative to the thermal range. It has been demonstrated that substituting surface temperature (Ts, ‘thermal approach’) with SWIR-transformed reflectance (STR, ‘optical approach’) to detect surface moisture is feasible with comparable results. (2) Methods: Using an iterative thresholding procedure to minimize within-class variance, the bilevel segmentation of variables derived from Landsat-8 representing surface moisture and vegetation cover was achieved for the 2020–2021 summer for a key irrigation district in Australia. (3) Results: The results of irrigated landcover by the optical approach were found to be comparable with those obtained by the thermal approach. The classification accuracy was assessed using water delivery records at the farm level. Although the overall accuracy was high in both cases, the optical approach (97.6%) performed slightly better than the thermal approach (93.9%). (4) Conclusions: The feasibility of using STR to map irrigated landcover has been confirmed by a high-level overall accuracy assessment. This has broader implications in terms of irrigated landcover assessment, as the use of satellite imagery in these applications may not necessarily be limited to microwave or thermal sensors. Full article

The coal loading operation of the coal preparation plant of an open pit coal mine causes chaos in coal mine vehicle scheduling due to the unreasonable arrival times of outgoing and container transportation vehicles. To further reduce the length of time that vehicle transportation equipment waits for each other and to reduce the total cost of container transportation, the optimisation model of container transportation vehicle scheduling in an open pit coal mine is constructed to minimise the minimum sum of the shortest time of container reversal and the lowest cost of container transportation. To accurately measure the total cost of container backward transportation, waiting time and unit waiting time cost parameters are introduced, and the total cost of container transportation is measured using the transportation cost and the waiting time cost transformation method. An improved grey wolf algorithm is proposed to speed up the convergence of the algorithm and improve the quality of the solution. When employing the genetic algorithm (GA) and grey wolf optimisation algorithm (GWO) for optimising the scheduling of container transport vehicles in coal mines, it is noted that while the GA can achieve the global optimum, its convergence speed is relatively slow. Conversely, the GWO converges more quickly, but it tends to be trapped in local optima. To accelerate the convergence speed of the algorithm and improve the solution quality, a hybrid GA−GWO algorithm is proposed, which introduces three genetic operations of selection, crossover, and mutation of GA into the GWO algorithm to prevent the algorithm from falling into the local optimum due to the fall; at the same time, it introduces hunting and attacking operations into the elite retention strategy of GA, which improves the stability of the algorithm’s global convergence. Analysis indicates that, compared to SA, GWO, and GA, the hybrid algorithm enhances optimisation speed by 43.1%, 46.2%, and 43.7%, increases optimisation accuracy by 4.12%, 6.1%, and 3.2%, respectively, and reduces the total container reversal time by 35.46, 22, and 31 h. The total cost of container transportation is reduced by 2437 RMB, 3512 RMB, and 1334 RMB, respectively. Full article