The 2023 MDPI Annual Report has
been released!
 
14 pages, 1410 KiB  
Article
Machine Learning Modeling to Predict Atrial Fibrillation Detection in Embolic Stroke of Undetermined Source Patients
by Chua Ming, Geraldine J. W. Lee, Yao Hao Teo, Yao Neng Teo, Emma M. S. Toh, Tony Y. W. Li, Chloe Yitian Guo, Jiayan Ding, Xinyan Zhou, Hock Luen Teoh, Swee-Chong Seow, Leonard L. L. Yeo, Ching-Hui Sia, Gregory Y. H. Lip, Mehul Motani and Benjamin YQ Tan
J. Pers. Med. 2024, 14(5), 534; https://doi.org/10.3390/jpm14050534 (registering DOI) - 16 May 2024
Abstract
Background: In patients with embolic stroke of undetermined source (ESUS), occult atrial fibrillation (AF) has been implicated as a key source of cardioembolism. However, only a minority acquire implantable cardiac loop recorders (ILRs) to detect occult paroxysmal AF, partly due to financial cost [...] Read more.
Background: In patients with embolic stroke of undetermined source (ESUS), occult atrial fibrillation (AF) has been implicated as a key source of cardioembolism. However, only a minority acquire implantable cardiac loop recorders (ILRs) to detect occult paroxysmal AF, partly due to financial cost and procedural inconvenience. Without the initiation of appropriate anticoagulation, these patients are at risk of increased ischemic stroke recurrence. Hence, cost-effective and accurate methods of predicting AF in ESUS patients are highly sought after. Objective: We aimed to incorporate clinical and echocardiography data into machine learning (ML) algorithms for AF prediction on ILRs in ESUS. Methods: This was a single-center cohort study that included 157 consecutive patients diagnosed with ESUS from October 2014 to October 2017 who had ILR evaluation. We developed four ML models, with hyperparameters tuned, to predict AF detection on an ILR. Results: The median age of the cohort was 67 (IQR 59–74) years old and the median monitoring duration was 1051 (IQR 478–1287) days. Of the 157 patients, 32 (20.4%) had occult AF detected on the ILR. Support vector machine predicted for AF with a 95% confidence interval area under the receiver operating characteristic curve (AUC) of 0.736–0.737, multilayer perceptron with an AUC of 0.697–0.708, XGBoost with an AUC of 0.697–0.697, and random forest with an AUC of 0.663–0.674. ML feature importance found that age, HDL-C, and admitting heart rate were important non-echocardiography variables, while peak mitral A-wave velocity and left atrial volume were important echocardiography parameters aiding this prediction. Conclusion: Machine learning modeling incorporating clinical and echocardiographic variables predicted AF in ESUS patients with moderate accuracy. Full article
(This article belongs to the Special Issue New Perspectives and Current Challenges in Myocardial Infarction)
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15 pages, 5040 KiB  
Article
Analysis of Environmental Impact and Mechanical Properties of Inconel 625 Produced Using Wire Arc Additive Manufacturing
by J. Iain Sword, Alexander Galloway and Athanasios Toumpis
Sustainability 2024, 16(10), 4178; https://doi.org/10.3390/su16104178 (registering DOI) - 16 May 2024
Abstract
Inconel 625 is a nickel-based superalloy widely used in industries such as energy, space, and defence, due to its strength and corrosion resistance. It is traditionally time- and resource-intensive to machine, leading to increased environmental impact and material waste. Using additive manufacturing (AM) [...] Read more.
Inconel 625 is a nickel-based superalloy widely used in industries such as energy, space, and defence, due to its strength and corrosion resistance. It is traditionally time- and resource-intensive to machine, leading to increased environmental impact and material waste. Using additive manufacturing (AM) technology enables a reduction in resource consumption during the manufacture of high value components, as material is only deposited where it is required. This study compares the environmental impact of manufacturing an Inconel 625 impeller through machining and wire arc additive manufacturing (WAAM) by employing established life cycle assessment methods. WAAM shows significant advantages, cutting energy consumption threefold and reducing material waste from 85% to 35%. The current work also evaluates the mechanical properties of WAAM-produced components through tensile and axial fatigue testing, in addition to the use of optical and electron microscopy for metallurgical analysis and fractography. This demonstrates yield and ultimate tensile strengths exceeding industrial standards, with comparable or superior fatigue life to other AM methods. The improved fatigue performance extends the service life of components, bolstering sustainability by reducing the need for frequent replacements, thereby lessening associated environmental impacts. These findings underscore the promise of WAAM in enhancing both environmental sustainability and mechanical performance in manufacturing Inconel 625 components. Full article
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17 pages, 3308 KiB  
Article
Fidelity Characterization of Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus and NADC30-like Strain
by Xiang Gao, Ting Bian, Peng Gao, Xinna Ge, Yongning Zhang, Jun Han, Xin Guo, Lei Zhou and Hanchun Yang
Viruses 2024, 16(5), 797; https://doi.org/10.3390/v16050797 (registering DOI) - 16 May 2024
Abstract
The porcine reproductive and respiratory syndrome virus (PRRSV) has significantly impacted the global pork industry for over three decades. Its high mutation rates and frequent recombination greatly intensifies its epidemic and threat. To explore the fidelity characterization of Chinese highly pathogenic PRRSV JXwn06 [...] Read more.
The porcine reproductive and respiratory syndrome virus (PRRSV) has significantly impacted the global pork industry for over three decades. Its high mutation rates and frequent recombination greatly intensifies its epidemic and threat. To explore the fidelity characterization of Chinese highly pathogenic PRRSV JXwn06 and the NADC30-like strain CHsx1401, self-recombination and mutation in PAMs, MARC-145 cells, and pigs were assessed. In vitro, CHsx1401 displayed a higher frequency of recombination junctions and a greater diversity of junction types than JXwn06. In vivo, CHsx1401 exhibited fewer junction types yet maintained a higher junction frequency. Notably, JXwn06 showed more accumulation of mutations. To pinpoint the genomic regions influencing their fidelity, chimeric viruses were constructed, with the exchanged nsp9-10 regions between JXwn06 and CHsx1401. The SJn9n10 strain, which incorporates JXwn06’s nsp9-10 into the CHsx1401 genome, demonstrated reduced sensitivity to nucleotide analogs compared to CHsx1401. Conversely, compared with JXwn06, the JSn9n10 strain showed increased sensitivity to these inhibitors. The swapped nsp9-10 also influences the junction frequency and accumulated mutations as their donor strains. The results indicate a propensity for different types of genetic variations between these two strains and further highlight the nsp9-10 region as a critical determinant of their fidelity. Full article
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13 pages, 2309 KiB  
Article
Reconstruction of Avian Reovirus History and Dispersal Patterns: A Phylodynamic Study
by Giovanni Franzo, Claudia Maria Tucciarone, Giulia Faustini, Francesca Poletto, Riccardo Baston, Mattia Cecchinato and Matteo Legnardi
Viruses 2024, 16(5), 796; https://doi.org/10.3390/v16050796 (registering DOI) - 16 May 2024
Abstract
Avian reovirus (ARV) infection can cause significant losses to the poultry industry. Disease control has traditionally been attempted mainly through vaccination. However, the increase in clinical outbreaks in the last decades demonstrated the poor effectiveness of current vaccination approaches. The present study reconstructs [...] Read more.
Avian reovirus (ARV) infection can cause significant losses to the poultry industry. Disease control has traditionally been attempted mainly through vaccination. However, the increase in clinical outbreaks in the last decades demonstrated the poor effectiveness of current vaccination approaches. The present study reconstructs the evolution and molecular epidemiology of different ARV genotypes using a phylodynamic approach, benefiting from a collection of more than one thousand sigma C (σC) sequences sampled over time at a worldwide level. ARVs’ origin was estimated to occur several centuries ago, largely predating the first clinical reports. The origins of all genotypes were inferred at least one century ago, and their emergence and rise reflect the intensification of the poultry industry. The introduction of vaccinations had only limited and transitory effects on viral circulation and further expansion was observed, particularly after the 1990s, likely because of the limited immunity and the suboptimal and patchy vaccination application. In parallel, strong selective pressures acted with different strengths and directionalities among genotypes, leading to the emergence of new variants. While preventing the spread of new variants with different phenotypic features would be pivotal, a phylogeographic analysis revealed an intricate network of viral migrations occurring even over long distances and reflecting well-established socio-economic relationships. Full article
(This article belongs to the Section Animal Viruses)
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10 pages, 1952 KiB  
Article
Laser Forced Dehydration of Benign Vascular Lesions of the Oral Cavity: A Valid Alternative to Surgical Techniques
by Margherita Gobbo and Luca Guarda-Nardini
Medicina 2024, 60(5), 822; https://doi.org/10.3390/medicina60050822 (registering DOI) - 16 May 2024
Abstract
Background and Objectives: Low-flow vascular lesions are commonly encountered in the oral cavity and may require removal due to aesthetic concerns, repeated bleeding or a cluttering sensation. Laser devices represent an excellent aid due to their affinity with blood and to their [...] Read more.
Background and Objectives: Low-flow vascular lesions are commonly encountered in the oral cavity and may require removal due to aesthetic concerns, repeated bleeding or a cluttering sensation. Laser devices represent an excellent aid due to their affinity with blood and to their biostimulating properties and have been substituting traditional excision in selected cases. Materials and Methods: In this study, 30 patients presenting with low-flow oral vascular lesions were included. The lesions were clinically evaluated as follows: lesion’s site, reason for treatment, lesion’s dimensions, confirmation of positive diascopy via compression with a glass slide and photograph. The lesions were treated with laser forced dehydration (LFD) and then followed-up after 3 weeks, 6 months and 1 year. The laser source was a K-Laser Blu Derma (Eltech, K-Laser S.r.l., Via Castagnole, 20/H, Treviso, Italy). In the case of incomplete healing, a further protocol was performed at the three-week follow-up, and a further follow-up was scheduled for three weeks after. The following aspects were evaluated at each appointment: pain, using a Numeric Rating Scale (NRS) from 0 to 10 (0 = no pain, 10 = worst pain ever); the need to take painkillers (day of intervention and during follow-up); bleeding (yes/no); scar formation. Results: Complete regression was obtained in all patients, with no side effects. Only one patient required a second LFD protocol. NRS was 0 for all patients for the whole duration of the follow-up. None of the patients took painkillers on the day of the intervention and during the follow-up. One patient declared slight bleeding the day of the intervention, which she easily managed at home. One patient showed a small non-retracting and non-painful scar at the three-week follow-up. No recurrences were found after six months and one year. Conclusions: LFD targets endogenous chromophores, minimizing damage to adjacent tissue and limiting side effects. LFD is effective and could be considered a conservative alternative to traditional excision in low-flow lesions. Full article
(This article belongs to the Special Issue Medicine and Dentistry: New Methods and Clinical Approaches)
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5 pages, 194 KiB  
Editorial
Detection, Control, Risk Assessment, and Prevention of Foodborne Microorganisms
by Arícia Possas and Fernando Pérez-Rodríguez
Foods 2024, 13(10), 1551; https://doi.org/10.3390/foods13101551 (registering DOI) - 16 May 2024
Abstract
Despite significant efforts from government and industry, enteric foodborne diseases continue to pose a substantial public health challenge worldwide [...] Full article
16 pages, 4253 KiB  
Article
Properties and Microstructure of a Cement-Based Capillary Crystalline Waterproofing Grouting Material
by Mengjie Wang, Xiaohua Yang, Kunlong Zheng and Rui Chen
Buildings 2024, 14(5), 1439; https://doi.org/10.3390/buildings14051439 (registering DOI) - 16 May 2024
Abstract
Cement grout is traditionally used for treating water leakage distress in tunnels. However, traditional cement grout has the disadvantages of a poor anti-seepage performance, long setting time, and slow strength gain. To this end, a high-performance cement-based capillary crystalline waterproofing (CCCW) grouting material [...] Read more.
Cement grout is traditionally used for treating water leakage distress in tunnels. However, traditional cement grout has the disadvantages of a poor anti-seepage performance, long setting time, and slow strength gain. To this end, a high-performance cement-based capillary crystalline waterproofing (CCCW) grouting material was synthesized using cement, capillary crystalline material, and several admixtures. The influences of the material proportions on the viscosity, bleeding rate, and setting time of the fresh grout, as well as the permeability coefficient of the grouted aggregate and the unconfined compression strength of the hardened grout material, were systematically studied. The mineralogy and microstructure of the CCCW grouting material were examined using X-ray diffraction, industrial computed tomography, and scanning electron microscopy. The results indicated that the capillary crystalline material PNC803 was not suitable for mixing with bentonite, sodium chloride, and triethanolamine in cementitious slurries, but it can produce excellent synergistic effects with sulfate, calcium chloride, and triisopropanolamine. An analysis of the microstructure of the CCCW grouting material showed that the PNC803 and additives can promote the hydration of cement, which yields more hydration products, sealing water passage and filling micro voids and therefore leading to enhanced waterproofing and strengthening effects. These research results could improve the applicability of CCCW material in tunnel engineering. Full article
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16 pages, 4994 KiB  
Article
Time- and Region-Specific Selection of Reference Genes in the Rat Brain in the Lithium–Pilocarpine Model of Acquired Temporal Lobe Epilepsy
by Alexander P. Schwarz, Maria V. Zakharova, Anna A. Kovalenko, Alexandra V. Dyomina, Olga E. Zubareva and Aleksey V. Zaitsev
Biomedicines 2024, 12(5), 1100; https://doi.org/10.3390/biomedicines12051100 (registering DOI) - 16 May 2024
Abstract
Reverse transcription followed by quantitative polymerase chain reaction (RT-qPCR) is a commonly used tool for gene expression analysis. The selection of stably expressed reference genes is required for accurate normalization. The aim of this study was to identify the optimal reference genes for [...] Read more.
Reverse transcription followed by quantitative polymerase chain reaction (RT-qPCR) is a commonly used tool for gene expression analysis. The selection of stably expressed reference genes is required for accurate normalization. The aim of this study was to identify the optimal reference genes for RT-qPCR normalization in various brain regions of rats at different stages of the lithium–pilocarpine model of acquired epilepsy. We tested the expression stability of nine housekeeping genes commonly used as reference genes in brain research: Actb, Gapdh, B2m, Rpl13a, Sdha, Ppia, Hprt1, Pgk1, and Ywhaz. Based on four standard algorithms (geNorm, NormFinder, BestKeeper, and comparative delta-Ct), we found that after pilocarpine-induced status epilepticus, the stability of the tested reference genes varied significantly between brain regions and depended on time after epileptogenesis induction (3 and 7 days in the latent phase, and 2 months in the chronic phase of the model). Pgk1 and Ywhaz were the most stable, while Actb, Sdha, and B2m demonstrated the lowest stability in the analyzed brain areas. We revealed time- and region-specific changes in the mRNA expression of the housekeeping genes B2m, Actb, Sdha, Rpl13a, Gapdh, Hprt1, and Sdha. These changes were more pronounced in the hippocampal region during the latent phase of the model and are thought to be related to epileptogenesis. Thus, RT-qPCR analysis of mRNA expression in acquired epilepsy models requires careful selection of reference genes depending on the brain region and time of analysis. For the time course study of epileptogenesis in the rat lithium–pilocarpine model, we recommend the use of the Pgk1 and Ywhaz genes. Full article
(This article belongs to the Special Issue Epilepsy: From Mechanisms to Therapeutic Approaches)
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13 pages, 1943 KiB  
Article
Fault Location Method Based on Dynamic Operation and Maintenance Map and Common Alarm Points Analysis
by Sheng Wu and Jihong Guan
Algorithms 2024, 17(5), 217; https://doi.org/10.3390/a17050217 (registering DOI) - 16 May 2024
Abstract
Under a distributed information system, the scale of various operational components such as applications, operating systems, databases, servers, and networks is immense, with intricate access relationships. The silo effect of each professional is prominent, and the linkage mechanism is insufficient, making it difficult [...] Read more.
Under a distributed information system, the scale of various operational components such as applications, operating systems, databases, servers, and networks is immense, with intricate access relationships. The silo effect of each professional is prominent, and the linkage mechanism is insufficient, making it difficult to locate the infrastructure components that cause exceptions under a particular application. Current research only plays a role in local scenarios, and its accuracy and generalization are still very limited. This paper proposes a novel fault location method based on dynamic operation maps and alarm common point analysis. During the fault period, various alarm entities are associated with dynamic operation maps, and alarm common points are obtained based on graph search addressing methods, covering deployment relationship common points, connection common points (physical and logical), and access flow common points. This method, compared with knowledge graph approaches, eliminates the complex process of knowledge graph construction, making it more concise and efficient. Furthermore, in contrast to indicator correlation analysis methods, this approach supplements with configuration correlation information, resulting in more precise positioning. Through practical validation, its fault hit rate exceeds 82%, which is significantly better than the existing main methods. Full article
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14 pages, 2234 KiB  
Article
Analyzing Exchange Rate Effects on Trade: Empirical Evidence
by Yosri Nasr Ahmed, Mohammed Alnafissa, Mosatafa M. Negm, Yasmine Mohieeldin Gharieb, Abdullah Algarini and Taghreed Abdel-Aziz Hassouba
Sustainability 2024, 16(10), 4177; https://doi.org/10.3390/su16104177 (registering DOI) - 16 May 2024
Abstract
In this study, we aimed to find a fair exchange rate for Egypt, exploring how exchange rate policies affect the country’s economic growth and food security. We also sought to answer an important question for Egyptian policymakers: “Do current exchange rate policies help [...] Read more.
In this study, we aimed to find a fair exchange rate for Egypt, exploring how exchange rate policies affect the country’s economic growth and food security. We also sought to answer an important question for Egyptian policymakers: “Do current exchange rate policies help reduce Egypt’s trade deficit?”. We used two methods in our research: First, we applied the purchasing power parity (PPP) method to determine the equilibrium real exchange rate (ERER). Then, we combined the computable general equilibrium model (CGE) with the ERER value from the PPP method to observe how different sectors interact with the overall economy and understand how household incomes and poverty levels are related. Our findings showed that the fair exchange rate is EGP 38.5 per US dollar, according to the PPP method. This new exchange rate may significantly impact the Egyptian economy. Some impacts are positive, such as better real GDP, more exports, and fewer imports; however, these are minor and not significant. On the downside, it may lead to higher inflation, increased prices for goods, and reduced consumption. Moreover, this study highlights the importance of having balanced exchange rate policies that consider Egypt’s unique economic situations, and challenges and align with other economic policies. Experience and reality have shown that exchange rates alone are not the only solution. Full article
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16 pages, 327 KiB  
Article
Plato’s Shadow: The Encroaching Doctrine of the Soul’s Immortality in the Early Church
by Matthew Lawrence Chambers
Humanities 2024, 13(3), 77; https://doi.org/10.3390/h13030077 (registering DOI) - 16 May 2024
Abstract
The influence of Plato’s concept of the soul as innately immortal and indestructible had a profoundly unbiblical influence upon many of the early church fathers’ views regarding human nature, the final judgment of the wicked, and God’s gift of immortality to believers. I [...] Read more.
The influence of Plato’s concept of the soul as innately immortal and indestructible had a profoundly unbiblical influence upon many of the early church fathers’ views regarding human nature, the final judgment of the wicked, and God’s gift of immortality to believers. I will argue my thesis by initially defining the nature of the soul according to the Hebrew Bible and the Christian New Testament, with an emphasis on its mortality. I will primarily utilize Scripture itself, although secondary sources—such as commentaries on the Hebrew and Greek versions—are essential due to interpretational differences. This will help to demonstrate how the Biblical view differs significantly from the Platonic view. Likewise, I will explore the Platonic view of the nature of the soul through the use of various primary and secondary sources. Additionally, I will use the writings of many early church fathers to highlight various instances in which the early church adopted the Platonic view of the soul and applied it to areas of their theology. Lastly, I will use both primary and secondary sources to make the case that the adoption of Platonic doctrine on the immortal soul has had an ‘unbiblical’ influence on how many Christians have viewed human nature, which alters the views of the final judgment of the wicked as well as the concept of God’s gift of immortality to believers in Christ. Ultimately, I will argue that this issue is important because it affects how we see the character of God and is, therefore, related to how we worship him. Full article
23 pages, 7242 KiB  
Article
A Multiphysics Simulation Study of the Thermomechanical Coupling Response of Energy Piles
by Chang Xu, Yawen Wang, Xiaolin Meng, Qihang Lv, Hui Chen and Qingdong Wu
Buildings 2024, 14(5), 1440; https://doi.org/10.3390/buildings14051440 (registering DOI) - 16 May 2024
Abstract
The global demand for energy is on the rise, accompanied by increasing requirements for low-carbon environmental protection. In recent years, China’s “double carbon action” initiative has brought about new development opportunities across various sectors. The concept of energy pile foundation aims to harness [...] Read more.
The global demand for energy is on the rise, accompanied by increasing requirements for low-carbon environmental protection. In recent years, China’s “double carbon action” initiative has brought about new development opportunities across various sectors. The concept of energy pile foundation aims to harness geothermal energy, aligning well with green, low-carbon, and sustainable development principles, thus offering extensive application prospects in engineering. Drawing from existing research globally, this paper delves into four key aspects impacting the thermodynamic properties of energy piles: the design of buried pipes, pile structure, heat storage materials within the pipe core, and soil treatment around the pile using carbon fiber urease mineralization. Leveraging the innovative mineralization technique known as urease-induced carbonate mineralization precipitation (EICP), this study employs COMSOL Multiphysics simulation software to analyze heat transfer dynamics and establish twelve sets of numerical models for energy piles. The buried pipe design encompasses two types, U-shaped and spiral, while the pile structure includes concrete solid energy piles and tubular energy piles. Soil conditions around the pile are classified into undisturbed sand and carbon fiber-infused EICP mineralized sand. Different inner core heat storage materials such as air, water, unaltered sand, and carbon fiber-based EICP mineralized sand are examined within tubular piles. Key findings indicate that spiral buried pipes outperform U-shaped ones, especially when filled with liquid thermal energy storage (TES) materials, enhancing temperature control of energy piles. The carbon fiber urease mineralization technique significantly improves heat exchange between energy piles and surrounding soil, reducing soil porosity to 4.9%. With a carbon fiber content of 1.2%, the ultimate compressive strength reaches 1419.4 kPa. Tubular energy piles mitigate pile stress during summer temperature fluctuations. Pile stress distribution varies under load and temperature stresses, with downward and upward friction observed at different points along the pile length. Overall, this research underscores the efficacy of energy pile technologies in optimizing energy efficiency while aligning with sustainable development goals. Full article
(This article belongs to the Special Issue Trends and Prospects in Civil Engineering Structures)
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11 pages, 4729 KiB  
Article
Preparation of Polyaniline-Modified Cellulose/PDMS Composite Triboelectric Material and Application of Its Pretreatment in MOW Pulp
by Xiaoping Sun, Yuhe Wei, Yanfen Sun, Juan Yuan, Haoqiu Chen, Zhuo Chen, Mengyang Wang and Lianxin Luo
Polymers 2024, 16(10), 1413; https://doi.org/10.3390/polym16101413 (registering DOI) - 16 May 2024
Abstract
Self-powered electronic equipment has rapidly developed in the fields of sensing, motion monitoring, and energy collection, posing a greater challenge to triboelectric materials. Triboelectric materials need to enhance their electrical conductivity and mechanical strength to address the increasing demand for stability and to [...] Read more.
Self-powered electronic equipment has rapidly developed in the fields of sensing, motion monitoring, and energy collection, posing a greater challenge to triboelectric materials. Triboelectric materials need to enhance their electrical conductivity and mechanical strength to address the increasing demand for stability and to mitigate unpredictable physical damage. In this study, polyaniline-modified cellulose was prepared by means of in situ polymerization and compounded with polydimethylsiloxane, resulting in a triboelectric material with enhanced strength and conductivity. The material was fabricated into a tubular triboelectric nanogenerator (TENG) (G-TENG), and an electrocatalytic pretreatment of mixed office waste paper (MOW) pulp was performed using papermaking white water as the flowing liquid to improve the deinking performance. The electrical output performance of G-TENG is highest at a flow rate of 400 mL/min, producing a voltage of 22.76 V and a current of 1.024 μA. Moreover, the deinking effect of MOW was enhanced after the electrical pretreatment. This study explores the potential application of G-TENG as a self-powered sensor power supply and emphasizes its prospect as an energy collection device. Full article
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20 pages, 7283 KiB  
Article
Synergistic Enhancement of Targeted Wound Healing by Near-Infrared Photodynamic Therapy and Silver Metal–Organic Frameworks Combined with S- or N-Doped Carbon Dots
by Maja D. Nešić, Iva A. Popović, Jelena Žakula, Lela Korićanac, Jelena Filipović Tričković, Ana Valenta Šobot, Maria Victoria Jiménez, Manuel Algarra, Tanja Dučić and Milutin Stepić
Pharmaceutics 2024, 16(5), 671; https://doi.org/10.3390/pharmaceutics16050671 (registering DOI) - 16 May 2024
Abstract
The literature data emphasize that nanoparticles might improve the beneficial effects of near-infrared light (NIR) on wound healing. This study investigates the mechanisms of the synergistic wound healing potential of NIR light and silver metal–organic frameworks combined with nitrogen- and sulfur-doped carbon dots [...] Read more.
The literature data emphasize that nanoparticles might improve the beneficial effects of near-infrared light (NIR) on wound healing. This study investigates the mechanisms of the synergistic wound healing potential of NIR light and silver metal–organic frameworks combined with nitrogen- and sulfur-doped carbon dots (AgMOFsN-CDs and AgMOFsS-CDs, respectively), which was conducted by testing the fibroblasts viability, scratch assays, biochemical analysis, and synchrotron-based Fourier transform infrared (SR-FTIR) cell spectroscopy and imaging. Our findings reveal that the combined treatment of AgMOFsN-CDs and NIR light significantly increases cell viability to nearly 150% and promotes cell proliferation, with reduced interleukin-1 levels, suggesting an anti-inflammatory response. SR-FTIR spectroscopy shows this combined treatment results in unique protein alterations, including increased α-helix structures and reduced cross-β. Additionally, protein synthesis was enhanced upon the combined treatment. The likely mechanism behind the observed changes is the charge-specific interaction of N-CDs from the AgMOFsN-CDs with proteins, enhanced by NIR light due to the nanocomposite’s optical characteristics. Remarkably, the complete wound closure in the in vitro scratch assay was achieved exclusively with the combined NIR and AgMOFsN-CDs treatment, demonstrating the promising application of combined AgMOFsN-CDs with NIR light photodynamic therapy in regenerative nanomedicine and tissue engineering. Full article
(This article belongs to the Special Issue Advances in Targeted Photodynamic Therapy Based on Nanotechnology)
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18 pages, 4155 KiB  
Article
Optimizing Transport Carrier Free All-Polymer Solar Cells for Indoor Applications: TCAD Simulation under White LED Illumination
by Marwa S. Salem, Mohamed Okil, Ahmed Shaker, Mohamed Abouelatta, Arwa N. Aledaily, Kawther A. Al-Dhlan, Mohammad T. Alshammari, Mostafa M. Salah and Mona El Sabbagh
Polymers 2024, 16(10), 1412; https://doi.org/10.3390/polym16101412 (registering DOI) - 16 May 2024
Abstract
This work inspects the utilization of all-polymer solar cells (APSCs) in indoor applications under LED illumination, with a focus on boosting efficiency through simulation-based design. The study employs a SCAPS TCAD device simulator to investigate the performance of APSCs under white LED illumination [...] Read more.
This work inspects the utilization of all-polymer solar cells (APSCs) in indoor applications under LED illumination, with a focus on boosting efficiency through simulation-based design. The study employs a SCAPS TCAD device simulator to investigate the performance of APSCs under white LED illumination at 1000 lux, with a power density of 0.305 mW/cm2. Initially, the simulator is validated against experimental results obtained from a fabricated cell utilizing CD1:PBN-21 as an absorber blend and PEDOT:PSS as a hole transportation layer (HTL), where the initial measured efficiency is 16.75%. The simulation study includes an examination of both inverted and conventional cell structures. In the conventional structure, where no electron transportation layer (ETL) is present, various materials are evaluated for their suitability as the HTL. NiO emerges as the most promising HTL material, demonstrating the potential to achieve an efficiency exceeding 27%. Conversely, in the inverted configuration without an HTL, the study explores different ETL materials to engineer the band alignment at the interface. Among the materials investigated, ZnS emerges as the optimal choice, recording an efficiency of approximately 33%. In order to reveal the efficiency limitations of these devices, the interface and bulk defects are concurrently investigated. The findings of this study underscore the significance of careful material selection and structural design in optimizing the performance of APSCs for indoor applications. Full article
(This article belongs to the Special Issue Application of Polymer Materials in Optoelectronic Devices)
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16 pages, 5520 KiB  
Article
A Combined Filtering Method for ZigBee Indoor Distance Measurement
by Zhe Wei and Zhanpeng Zhou
Sensors 2024, 24(10), 3164; https://doi.org/10.3390/s24103164 (registering DOI) - 16 May 2024
Abstract
Indoor distance measurement technology utilizing Zigbee’s Received Signal Strength Indication (RSSI) offers cost-effective and energy-efficient advantages, making it widely adopted for indoor distance measurement applications. However, challenges such as multipath effects, signal attenuation, and signal blockage often degrade the accuracy of distance measurements. [...] Read more.
Indoor distance measurement technology utilizing Zigbee’s Received Signal Strength Indication (RSSI) offers cost-effective and energy-efficient advantages, making it widely adopted for indoor distance measurement applications. However, challenges such as multipath effects, signal attenuation, and signal blockage often degrade the accuracy of distance measurements. Addressing these issues, this study proposes a combined filtering approach integrating Kalman filtering, Dixon’s Q-test, Gaussian filtering, and mean filtering. Initially, the method evaluates Zigbee’s transmission power, channel, and other parameters, analyzing their impact on RSSI values. Subsequently, it fits a signal propagation loss model based on actual measured data to understand the filtering algorithm’s effect on distance measurement error. Experimental results demonstrate that the proposed method effectively improves the conversion relationship between RSSI and distance. The average distance measurement error, approximately 0.46 m, substantially outperforms errors derived from raw RSSI data. Consequently, this method offers enhanced distance measurement accuracy, making it particularly suitable for indoor positioning applications. Full article
(This article belongs to the Special Issue Indoor Positioning Technologies for Internet-of-Things)
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21 pages, 23185 KiB  
Article
InSAR-DEM Block Adjustment Model for Upcoming BIOMASS Mission: Considering Atmospheric Effects
by Kefu Wu, Haiqiang Fu, Jianjun Zhu, Huacan Hu, Yi Li, Zhiwei Liu, Afang Wan and Feng Wang
Remote Sens. 2024, 16(10), 1764; https://doi.org/10.3390/rs16101764 (registering DOI) - 16 May 2024
Abstract
The unique P-band synthetic aperture radar (SAR) instrument, BIOMASS, is scheduled for launch in 2024. This satellite will enhance the estimation of subcanopy topography, owing to its strong penetration and fully polarimetric observation capability. In order to conduct global-scale mapping of the subcanopy [...] Read more.
The unique P-band synthetic aperture radar (SAR) instrument, BIOMASS, is scheduled for launch in 2024. This satellite will enhance the estimation of subcanopy topography, owing to its strong penetration and fully polarimetric observation capability. In order to conduct global-scale mapping of the subcanopy topography, it is crucial to calibrate systematic errors of different strips through interferometric SAR (InSAR) DEM (digital elevation model) block adjustment. Furthermore, the BIOMASS mission will operate in repeat-pass interferometric mode, facing the atmospheric delay errors introduced by changes in atmospheric conditions. However, the existing block adjustment methods aim to calibrate systematic errors in bistatic mode, which can avoid possible errors from atmospheric effects through interferometry. Therefore, there is still a lack of systematic error calibration methods under the interference of atmospheric effects. To address this issue, we propose a block adjustment model considering atmospheric effects. Our model begins by employing the sub-aperture decomposition technique to form forward-looking and backward-looking interferograms, then multi-resolution weighted correlation analysis based on sub-aperture interferograms (SA-MRWCA) is utilized to detect atmospheric delay errors. Subsequently, the block adjustment model considering atmospheric effects can be established based on the SA-MRWCA. Finally, we use robust Helmert variance component estimation (RHVCE) to build the posterior stochastic model to improve parameter estimation accuracy. Due to the lack of spaceborne P-band data, this paper utilized L-band Advanced Land Observing Satellite (ALOS)-1 PALSAR data, which is also long-wavelength, to emulate systematic error calibration of the BIOMASS mission. We chose climatically diverse inland regions of Asia and the coastal regions of South America to assess the model’s effectiveness. The results show that the proposed block adjustment model considering atmospheric effects improved accuracy by 72.2% in the inland test site, with root mean square error (RMSE) decreasing from 10.85 m to 3.02 m. Moreover, the accuracy in the coastal test site improved by 80.2%, with RMSE decreasing from 16.19 m to 3.22 m. Full article
(This article belongs to the Special Issue Remote Sensing for Geology and Mapping)
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23 pages, 11127 KiB  
Article
Axial Impact Resistance of High-Strength Engineering Geopolymer Composites: Effect of Polyethylene Fiber Content and Strain Rate
by Yu Ling, Xiafei Zhang, Weiyu Zou, Chang Feng, Huaming Lai, Jialin Yang and Beixin Xie
Buildings 2024, 14(5), 1438; https://doi.org/10.3390/buildings14051438 (registering DOI) - 16 May 2024
Abstract
High-strength engineered geopolymer composite (EGC) materials exhibit excellent mechanical properties under quasistatic loading, thus showing great potential in military and civilian facilities subjected to impact or explosive loading. However, its dynamic mechanical response under high-speed loading is not fully understood. In this study, [...] Read more.
High-strength engineered geopolymer composite (EGC) materials exhibit excellent mechanical properties under quasistatic loading, thus showing great potential in military and civilian facilities subjected to impact or explosive loading. However, its dynamic mechanical response under high-speed loading is not fully understood. In this study, dynamic compressive test was performed on EGC with PE fiber contents of 0%, 0.5%, 1.0%, 1.5%, and 2.0% using the Split Hopkinson Pressure Bar (SHPB) test. The results indicated that EGC reinforced with 1.5% fiber exhibited optimal static and dynamic mechanical performance. In the strain rate range of 181 s−1 to 201 s−1, when the fiber content increased from 1.0% to 1.5% and 2.0%, the dynamic compressive strength of the EGC increased by 24.3%, 28.8%, and 44.0%, respectively, compared to the matrix without fiber. Dynamic parameters of the EGC, including dynamic compressive strength, dynamic increase factor, and impact toughness, showed sensitivity to strain rates and increased with strain rate. A modified model, incorporating the fiber bridging effect, was proposed based on the CEB-FIP model, providing important guidance for practical engineering applications. Full article
(This article belongs to the Special Issue Next-Gen Cementitious Composites for Sustainable Construction)
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15 pages, 2038 KiB  
Review
Use of Commercial Mixed-Mode Stationary Phases and Sorbents in the High-Performance Liquid Chromatography Analysis and Solid-Phase Extraction of Ionized and Hydrophilic Bioactive Compounds
by Takeshi Fukushima, Mikoto Koishi, Tatsuya Sakamoto and Mayu Onozato
Molecules 2024, 29(10), 2341; https://doi.org/10.3390/molecules29102341 (registering DOI) - 16 May 2024
Abstract
Mixed-mode high-performance liquid chromatography (HPLC) is increasingly used for the analysis of ionic and highly hydrophilic drugs, which are difficult to separate by conventional single-mode HPLC. In the former case, chromatographic separation is achieved using one of the several commercially available mixed-mode stationary [...] Read more.
Mixed-mode high-performance liquid chromatography (HPLC) is increasingly used for the analysis of ionic and highly hydrophilic drugs, which are difficult to separate by conventional single-mode HPLC. In the former case, chromatographic separation is achieved using one of the several commercially available mixed-mode stationary phases, typically combinations of reversed and ion-exchange phases. Moreover, mixed-mode stationary phases can be used as solid-phase extraction (SPE) sorbents. This review focuses on the recent applications of mixed-mode stationary phases in the chromatographic analysis of bioactive compounds, such as drugs, herbicides, and pesticides. Specifically, we briefly summarize HPLC methods utilizing mixed-mode stationary phases and SPE pretreatment procedures utilizing mixed-mode sorbents developed in the last decade, thus providing a reference work for overcoming the difficulties in analyzing ionized or hydrophilic drugs by conventional reversed-phase chromatography. Full article
(This article belongs to the Special Issue Review Papers in Analytical Chemistry)
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16 pages, 319 KiB  
Article
Feedback Stabilization of Quasi-One-Sided Lipschitz Nonlinear Discrete-Time Systems with Reduced-Order Observer
by Yanbin Zhao and Wenqiang Dong
Mathematics 2024, 12(10), 1553; https://doi.org/10.3390/math12101553 (registering DOI) - 16 May 2024
Abstract
The feedback stabilization problem for nonlinear discrete-time systems with a reduced-order observer is investigated, in which the nonlinear terms of the systems satisfy the quasi-one-sided Lipschitz condition. First, a discrete-time reduced-order observer for nonlinear systems is designed. Then, a feedback controller with a [...] Read more.
The feedback stabilization problem for nonlinear discrete-time systems with a reduced-order observer is investigated, in which the nonlinear terms of the systems satisfy the quasi-one-sided Lipschitz condition. First, a discrete-time reduced-order observer for nonlinear systems is designed. Then, a feedback controller with a reduced-order observer is designed for realizing the stabilization of nonlinear discrete-time systems. We prove that the design of a feedback controller and reduced-order observer of systems can be carried out independently in the case of discrete-time with nonlinear terms, which largely reduces the computational complexity of the observer and controller. The introduction of the quasi-one-sided Lipschitz condition simultaneously enhances the robustness and stability of nonlinear control systems. Finally, the feasibility and effectiveness of the proposed design approach is verified by a numerical simulation. Full article
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23 pages, 4831 KiB  
Article
Influence of pH on Room-Temperature Synthesis of Zinc Oxide Nanoparticles for Flexible Gas Sensor Applications
by Fazia Mechai, Ahmad Al Shboul, Mohand Outahar Bensidhoum, Hossein Anabestani, Mohsen Ketabi and Ricardo Izquierdo
Chemosensors 2024, 12(5), 83; https://doi.org/10.3390/chemosensors12050083 (registering DOI) - 16 May 2024
Abstract
This research contributes to work on synthesizing zinc oxide nanoparticles (ZnO NPs) at room temperature (RT) and their utilization in flexible gas sensors. RT ZnO NP synthesis with a basicity solution (pH ≈ 13) demonstrates an efficient method for synthesizing well-crystalline ZnO NPs [...] Read more.
This research contributes to work on synthesizing zinc oxide nanoparticles (ZnO NPs) at room temperature (RT) and their utilization in flexible gas sensors. RT ZnO NP synthesis with a basicity solution (pH ≈ 13) demonstrates an efficient method for synthesizing well-crystalline ZnO NPs (RT.pH13) comparable to those synthesized by the hydrothermal method (hyd.C). The RT.pH13 achieved a high thermal stability with minimal organic reside impurities (~4.2 wt%), 30–80 nm particle size distribution, and a specific surface area (14 m2 g−1). The synthesized pre- and post-calcinated RT.pH13 NPs were then incorporated into flexible sensors for gas sensing applications at ambient conditions (RT and relative humidity of 30–50%). The pre-calcinated ZnO-based sensor (RT.pH13) demonstrated superior sensitivity to styrene and acetic acid and lower sensitivity to dimethyl-6-octenal. The calcinated ZnO-based sensor (RT.pH13.C) exhibited lower sensitivity to styrene and acetic acid, but heightened sensitivity to benzene, acetone, and ethanol. This suggests a correlation between sensitivity and structural transformations following calcination. The investigation of the sensing mechanisms highlighted the role of surface properties in the sensors’ affinity for specific gas molecules and temperature and humidity variations. The study further explored the sensors’ mechanical flexibility, which is crucial for flexible Internet of Things (IoT) applications. Full article
(This article belongs to the Special Issue Advances in Gas Sensors and their Application)
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13 pages, 4017 KiB  
Article
Characterization Data for the Establishment of Scale-Up and Process Transfer Strategies between Stainless Steel and Single-Use Bioreactors
by Vincent Bernemann, Jürgen Fitschen, Marco Leupold, Karl-Heinz Scheibenbogen, Marc Maly, Marko Hoffmann, Thomas Wucherpfennig and Michael Schlüter
Fluids 2024, 9(5), 115; https://doi.org/10.3390/fluids9050115 (registering DOI) - 16 May 2024
Abstract
The reliable transfer of bioprocesses from single-use bioreactors (SUBs) of different scales to conventional stainless steel stirred-tank bioreactors is of steadily growing interest. In this publication, a scale-up study for SUBs with volumes of 200 L and 2000 L and the transfer to [...] Read more.
The reliable transfer of bioprocesses from single-use bioreactors (SUBs) of different scales to conventional stainless steel stirred-tank bioreactors is of steadily growing interest. In this publication, a scale-up study for SUBs with volumes of 200 L and 2000 L and the transfer to an industrial-scale conventional stainless steel stirred-tank bioreactor with a volume of 15,000 L is presented. The scale-up and transfer are based on a comparison of mixing times and the modeling of volumetric mass transfer coefficients kLa, measured in all three reactors in aqueous PBS/Kolliphor solution. The mass transfer coefficients are compared with the widely used correlation of van’t Riet at constant stirrer tip speeds. It can be shown that a van’t Riet correlation enables a robust and reliable prediction of mass transfer coefficients on each scale for a wide range of stirrer tip speeds and aeration rates. The process transfer from single-use bioreactors to conventional stainless steel stirred-tank bioreactors is proven to be uncritical concerning mass transfer performance. This provides higher flexibility with respect to bioreactor equipment considered for specific processes. Full article
(This article belongs to the Special Issue Mass Transfer in Multiphase Reactors)
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19 pages, 4375 KiB  
Article
Diatom Biosilica Functionalised with Metabolically Deposited Cerium Oxide Nanoparticles
by Izabela Wojtczak, Weronika Brzozowska, Grzegorz Trykowski and Myroslav Sprynskyy
Materials 2024, 17(10), 2390; https://doi.org/10.3390/ma17102390 (registering DOI) - 16 May 2024
Abstract
This study introduces a novel approach to synthesising a three-dimensional (3D) micro-nanostructured amorphous biosilica. The biosilica is coated with cerium oxide nanoparticles obtained from laboratory-grown unicellular photosynthetic algae (diatoms) doped metabolically with cerium. This unique method utilises the ability of diatom cells to [...] Read more.
This study introduces a novel approach to synthesising a three-dimensional (3D) micro-nanostructured amorphous biosilica. The biosilica is coated with cerium oxide nanoparticles obtained from laboratory-grown unicellular photosynthetic algae (diatoms) doped metabolically with cerium. This unique method utilises the ability of diatom cells to absorb cerium metabolically and deposit it on their silica exoskeleton as cerium oxide nanoparticles. The resulting composite (Ce-DBioSiO2) combines the unique structural and photonic properties of diatom biosilica (DBioSiO2) with the functionality of immobilised CeO2 nanoparticles. The kinetics of the cerium metabolic insertion by diatom cells and the physicochemical properties of the obtained composites were thoroughly investigated. The resulting Ce-DBioSiO2 composite exhibits intense Stokes fluorescence in the violet–blue region under ultraviolet (UV) irradiation and anti-Stokes intense violet and faint green emissions under the 800 nm near-infrared excitation with a xenon lamp at room temperature in an ambient atmosphere. Full article
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