Electroplated diamond wire sawing is widely used as a processing method to cut hard and brittle difficult-to-machine materials. Currently, obtaining the sawing capability of diamond wire saw through the wire bow is still difficult. In this paper, a method for calculating the sawing capability of diamond wire saw in real-time based on the wire bow is proposed. The influence of the renewed length per round trip, crystal orientation of sapphire, wire speed, and feed rate on the wire sawing capability has been revealed via slicing experiments. The results indicate that renewing the diamond wire saw, and reducing the wire speed and feed rate can delay the reduction in sawing capability. Furthermore, controlling the value of renewed length per round trip can make the diamond wire saw enter a stable cutting state, in which the capability of the wire saw no longer decreases. The sawing capability of diamond wire saw cutting in the A-plane of the sapphire is smaller than that of the C-plane, and a suitable feed rate or wire speed within the range of sawing parameters studied in this study can avoid a rapid decrease in the sawing capability of the wire saw during the cutting process. The knowledge obtained in this study provides a theoretical basis for monitoring the performance of the wire saw, and guidance for the wire cutting process in semiconductor manufacturing. In the future, it may even be possible to provide real-time performance parameters of diamond wire saw for the digital twin model of wire sawing. Full article

Cold-pressed moringa, milk thistle, and jujube seed oils were investigated in terms of their characteristic profiles, thermal properties, and oxidative stability. The findings proved that the extracted oils were characterized by high nutritional values, which encourages their use in various fields. Results showed significant differences between the obtained oils. Overall, jujube seed oil exhibited the best quality parameters, with acidity equal to 0.762 versus 1% for the moringa and milk thistle seed oils. Milk thistle seed oil showed absorbance in the UV-C (100–290 nm), UV-B (290–320 nm), and UV-A (320–400 nm) ranges, while the moringa and jujube seed oils showed absorbance only in the UV-B and UV-A ranges. Concerning bioactive compounds, jujube seed oil presented the highest content of polyphenols, which promoted a good scavenging capacity (90% at 10 µg/mL) compared to the moringa and milk thistle seed oils. Assessing the thermal properties of the obtained oils showed the presence of four groups of triglycerides in the moringa and milk thistle seed oils, and two groups of triglycerides in the jujube seed oil. The thermograms were constant at temperatures above 10 °C for milk thistle seed oil, 15 °C for jujube seed oil, and 30 °C for moringa seed oil, which corresponded to complete liquefaction of the oils. The extinction coefficients K₂₃₂ and K₂₇₀, monitored during storage for 60 days at 60 °C, proved that jujube seed oil had the highest polyphenols content and was the most stable against thermal oxidation. Full article

Re-expansion pulmonary edema is a rare and potentially life-threatening complication that can occur after the rapid re-expansion of a collapsed lung due to pneumothorax or pleural effusion. It has a multifactorial pathogenesis, and risk factors for re-expansion pulmonary edema, such as chronic lung collapse, rapid re-expansion, and changes in pulmonary vascular permeability, have been identified. Clinical manifestations vary, ranging from almost asymptomatic to a rapidly fatal condition, and its incidence may be more common and less fatal than previously believed. The literature emphasizes the importance of early recognition and management to ensure favorable outcomes. However, there is ongoing debate regarding the indications for ventilatory support and the timing of non-invasive or invasive ventilation. Herein, we report a case series of three paradigmatic examples of massive re-expansion pulmonary edema occurring over a period of 10 years in our institution among a population of 815 patients with spontaneous pneumothorax. We also conducted a literature review on re-expansion pulmonary edema, with a particular focus on diagnosis and management. In each case, despite initially normal clinical parameters, severe respiratory distress developed following the insertion of a thoracic drainage tube for a massive spontaneous pneumothorax. Two patients required High-Flow Nasal Oxygen, and one was addressed to intensive management, including CPAP. In all cases, the patient’s outcome was optimal. Full article

A proton exchange membrane fuel cell (PEMFC) is an efficient and environmentally friendly power production technology that uses hydrogen energy. The cathodic oxygen reduction electrode is a critical component in the development of PEMFC. Most techniques deposit catalyst nanoparticles in areas that are inaccessible for catalytic processes, reducing platinum utilization. The substrate used in this study was carbon paper (CP) with a self-supporting structure. First, electrochemical acidification technology was employed to modify the CP’s surface, followed by nanoparticle manufacturing and fixation on the CP in a single step by electrodeposition. The Pt/C_0.5V_2.24CP catalyst electrode demonstrated high-quality activity in the oxygen reduction reaction (ORR), with a homogeneous particle dispersion and particle size of around 50 nm. The mass activity and electrochemical active surface area (ECSA) of the Pt/C_0.5V_2.24CP catalyst electrode were 1.74 and 3.98 times higher than those of the Pt/C/CP-1 electrodes made with commercial catalysts, respectively. After 5000 cycles of accelerated durability testing (ADT), the mass activity and ECSA were 1.28 times and 6.16 times more than Pt/C/CP-1. This paper successfully proved the viability of electrodepositing Pt nanoparticles on CP following acidification, and that the electrochemical acidification methods have a positive influence on improving electrode ORR activity. Full article

The expectile-based Value at Risk (EVaR) has gained popularity as it is more sensitive to the magnitude of extreme losses than the conventional quantile-based VaR (QVaR). This paper applies the expectile regression approach to evaluate the EVaR of stock market indices of Australia and Japan. We use an expectile regression model that considers lagged returns and common risk factors to calculate the EVaR for each stock market and to evaluate the interdependence of downside risk between the two markets. Our findings suggest that both Australian and Japanese stock markets are affected by their past development and the international stock markets. Additionally, ASX 200 index has significant impact on Nikkei 225 in terms of downside tail risk, while the impact of Nikkei 225 on ASX is not significant. Full article

(1) Background: Carboplatin (CBP) is a chemotherapeutic drug widely used in the treatment of a variety of cancers. Despite its efficiency, CBP is associated with side effects that greatly limit its clinical use. To mitigate these effects, CBP can be encapsulated in targeted delivery systems, such as liposomes. Ensuring the adequate loading and release of CBP from these carriers requires strict control in pharmaceutical formulation development, demanding modern, rapid, and robust analytical methods. The aim of this study was the development of a sensor for the fast and accurate quantification of CBP and its application on proof-of-concept CBP-loaded nanosomes. (2) Methods: Screen-printed electrodes were obtained in-lab and the electrochemical behavior of CBP was tested on the obtained electrodes. (3) Results: The in-lab screen-printed electrodes demonstrated superior properties compared to commercial ones. The novel sensors demonstrated accurate detection of CBP on a dynamic range from 5 to 500 μg/mL (13.5–1350 μM). The method was successfully applied on CBP loaded and released from nanosomes, with strong correlations with a spectrophotometric method used as control. (4) Conclusions: This study demonstrates the viability of electrochemical techniques as alternative options during the initial phases of pharmaceutical formulation development. Full article

Developing high-performance and low-cost protein purification materials is of great importance to meet the demands for highly purified proteins in biotechnological industries. Herein, a facile strategy was developed to design and construct high-efficiency protein absorption and separation media by combining aerogels’ molding techniques and impregnation processes. Poly (ethylene-co-vinyl alcohol) (EVOH) nanofibrous aerogels (NFAs) were modified by grafting butane tetracarboxylic acid (BTCA) over them in situ. This modification was carried out using polyphosphoric acid as a catalyst. The resulting EVOH/BTCA NFAs exhibited favorable comprehensive properties. Benefiting from the highly interconnected porous structure, good underwater compressive properties, and abundant absorption ligands, the obtained EVOH/BTCA NFAs possessed a high static absorption capacity of 1082.13 mg/g to lysozyme and a short absorption equilibrium time of about 6 h. A high saturated dynamic absorption capacity for lysozyme (716.85 mg/g) was also realized solely by gravity. Furthermore, EVOH/BTCA NFAs displayed excellent reusability, good acid and alkaline resistance, and unique absorption selectivity performance. The successful synthesis of such aerogels can provide a potential candidate for next-generation protein absorbents for bio-separation and purification engineering. Full article

Icing on the blades of wind turbines during winter seasons causes a reduction in power and revenue losses. The prediction of icing before it occurs has the potential to enable mitigating actions to reduce ice accumulation. This paper presents a framework for the prediction of icing on wind turbines based on Supervisory Control and Data Acquisition (SCADA) data without requiring the installation of any additional icing sensors on the turbines. A Temporal Convolutional Network is considered as the model to predict icing from the SCADA data time series. All aspects of the icing prediction framework are described, including the necessary data preprocessing, the labeling of SCADA data for icing conditions, the selection of informative icing features or variables in SCADA data, and the design of a Temporal Convolutional Network as the prediction model. Two performance metrics to evaluate the prediction outcome are presented. Using SCADA data from an actual wind turbine, the model achieves an average prediction accuracy of $77.6\%$ for future times of up to 48 h. Full article

This paper presents a low-power, energy-efficient, 12-bit incremental zoom analog-to-digital converter (ADC) for multi-channel bio-signal acquisitions. The ADC consists of a 7-stage ring voltage-controlled oscillator (VCO)-based incremental ΔΣ modulator (I-ΔΣM) and an 8-bit successive approximation register (SAR) ADC. The proposed VCO-based I-ΔΣM can provide fast phase-alignment of the ring-VCO to reduce the interval settling time; thereby, the I-ΔΣM can accommodate time-division-multiplexed input signals without phase leakage between consecutive measurements. The SAR ADC also adopts splitting unit capacitors that can support V_CM-free tri-level switching and prevent invalid states from the phase frequency detector with minimal logic gates and switches. The proposed ADC has been fabricated in a standard 180 nm standard 1P6M CMOS process, exhibiting a 67-dB peak signal-to-noise ratio, a 74-dB dynamic range, and a Walden figure of merit of 19.12 fJ/c-s, while consuming a power of 3.51 μW with a sampling rate of 100 kS/s. Full article

The accurate determination of the Diameter at Breast Height (DBH) of Moso bamboo is crucial for estimating biomass and carbon storage in Moso bamboo forests. In this research, we utilized handheld LiDAR point cloud data to extract the DBH of Moso bamboo and enhanced the accuracy of diameter fitting by optimizing denoising parameters. Specifically, we fine-tuned two denoising parameters, neighborhood point number and standard deviation multiplier, across five gradient levels for denoising. Subsequently, DBH fitting was conducted on data processed with varying denoising parameters, followed by a precision evaluation to investigate the key factors influencing the accuracy of Moso bamboo DBH fitting. The research results indicate that a handheld laser was used to scan six plots, from which 132 single Moso bamboo trees were selected. Out of these, 122 single trees were successfully segmented and identified, achieving an accuracy rate of 92.4% in identifying single Moso bamboo trees, with an average accuracy of 95.64% in extracting DBH for individual plants; the mean error was ±1.8 cm. Notably, setting the minimum neighborhood point to 10 resulted in the highest fitting accuracy for DBH. Moreover, the optimal standard deviation multiplier threshold was found to be 1 in high-density forest plots and 2 in low-density forest plots. Forest condition and slope were identified as the primary factors impacting the accuracy of Moso bamboo DBH fitting. Full article

The Pacific white shrimp, Penaeus vannamei, is highly susceptible to white spot syndrome virus (WSSV). Our study explored the transcriptomic responses of P. vannamei from resistant and susceptible families, uncovering distinct expression patterns after WSSV infection. The analysis revealed a higher number of differentially expressed genes (DEGs) in the susceptible family following WSSV infection compared to the resistant family, when both were evaluated against their respective control groups, indicating that the host resistance of the family line influences the transcriptome. The results also showed that subsequent to an identical duration following WSSV infection, there were more DEGs in P. vannamei with a high viral load than in those with a low viral load. To identify common transcriptomic responses, we profiled DEGs across families at 96 and 228 h post-infection (hpi). The analysis yielded 64 up-regulated and 37 down-regulated DEGs at 96 hpi, with 33 up-regulated and 34 down-regulated DEGs at 228 hpi, showcasing the dynamics of the transcriptomic response over time. Real-time RT-PCR assays confirmed significant DEG expression changes post-infection. Our results offer new insights into shrimp’s molecular defense mechanisms against WSSV. Full article

The evolution of the translation system is a fundamental issue in the quest for the origin of life. A feasible evolutionary scenario necessitates the autonomous emergence of a protoribosome capable of catalyzing the synthesis of the initial peptides. The peptidyl transferase center (PTC) region in the modern ribosomal large subunit is believed to retain a vestige of such a prebiotic non-coded protoribosome, which would have self-assembled from random RNA chains, catalyzed peptide bond formation between arbitrary amino acids, and produced short peptides. Recently, three research groups experimentally demonstrated that several distinct dimeric constructs of protoribosome analogues, derived predicated on the approximate 2-fold rotational symmetry inherent in the PTC region, possess the ability to spontaneously fold, dimerize, and catalyze the formation of peptide bonds and of short peptides. These dimers are examined, aiming at retrieving information concerned with the characteristics of a prebiotic protoribosome. The analysis suggests preconditions for the laboratory re-creation of credible protoribosome analogues, including the preference of a heterodimer protoribosome, contradicting the common belief in the precedence of homodimers. Additionally, it derives a dynamic process which possibly played a role in the spontaneous production of the first bio-catalyzed peptides in the prebiotic world. Full article

As critical equipment in nuclear power systems, the stability of circulating water pumps (CWP) directly impacts the efficiency of power plants. To investigate the impact mechanisms of the unsteady flow characteristics and flow-induced forces on the rotation system, numerical simulation methods were employed to calculate the internal flow of a volute mixed-flow CWP under different flow rates (0.8Q_d, 1.0Q_d, 1.2Q_d). The flow field results indicate that, under the part-load condition, the flow within the volute is chaotic with high energy losses, while under the over-load condition, there is a significant velocity gradient within the impeller, leading to relatively severe flow losses. Additionally, the rotor–stator interface is a major factor in flow-induced pulsations, and the asymmetric pressure distribution within the volute results in radial force imbalance. The finite element method (FEM) results indicate that the position of maximum stress on the pump shaft is closely related to the ratio of radial and axial force. Increasing the flow rate appropriately has been noted to be advantageous in reducing flow-induced forces and their amplitude, consequently diminishing the forces on the rotation system and improving the long-term operational stability of the CWP. Full article

Greece has been malaria-free since 1974, after an intense malaria control program. However, as Greece hosts migrant populations from P. vivax malaria-endemic countries, there is a risk of introducing the disease to specific vulnerable and receptive areas of the country. Knowledge of the genetic diversity of P. vivax populations is essential for understanding the dynamics of malaria disease transmission in a given region. We used nine highly polymorphic markers to genotype 124 P. vivax-infected archived DNA samples from human blood specimens referred to the NMRL from all over Greece throughout 2015–2019. The genotypic variability of the samples studied was noted, as they comprised several unique haplotypes, indicative of the importation of a large number of different P. vivax strains in the country. However, only a few events of local transmission were recorded. Genotyping revealed and confirmed the same clusters as those identified through epidemiological investigation. In only one introduction event was the index case found. No sustained/ongoing malaria transmissions in/between the studied regions or during consecutive years or additional foci of local transmission were observed. Genotyping is an important component in assisting malaria surveillance, as it provides information concerning the patterns of introduction and the effectiveness of implemented malaria control and elimination measures. Full article

Ternary organic solar cells contain a single three-component photoactive layer with a wide absorption window, achieved without the need for multiple stacking. However, adding a third component into a well-known binary blend can influence the energetics, optical window, charge carrier transport, crystalline order and conversion efficiency. In the form of binary blends, the low-bandgap regioregular polymer donor poly(3-hexylthiophene-2,5-diyl), known as P3HT, is combined with the acceptor PC₆₁BM, an inexpensive fullerene derivative. Two different non-fullerene acceptors (ITIC and eh-IDTBR) are added to this binary blend to form ternary blends. A systematic comparison between binary and ternary systems was carried out as a function of the thermal annealing temperature of organic layers (100 °C and 140 °C). The power conversion efficiency (PCE) is improved due to increased fill factor (FF) and open-circuit voltage (V_oc) for thermal-annealed ternary blends at 140 °C. The transport properties of electrons and holes were investigated in binary and ternary blends following a Space-Charge-Limited Current (SCLC) protocol. A favorable balanced hole–electron mobility is obtained through the incorporation of either ITIC or eh-IDTBR. The charge transport behavior is correlated with the bulk heterojunction (BHJ) morphology deduced from atomic force microscopy (AFM), contact water angle (CWA) measurement and 2D grazing-incidence X-ray diffractometry (2D-GIXRD). Full article

Bacterial chondronecrosis with osteomyelitis (BCO) lameness is a bone disease characterized by the translocation of bacteria from the gastrointestinal tract, which colonize microfractures in broiler leg bones caused by rapid animal growth rate and weight gain, resulting in lameness. As such, BCO lameness represents a significant challenge for the poultry industry. This study aims to evaluate the effect of spraying broiler chicks on d0 at hatch with an Enterococcus faecium probiotic on the incidence of BCO-induced lameness, utilizing a Staphylococcus aureus challenge model. There were four treatments: (1) negative control (no probiotic + no challenge, NC); (2) positive control (no probiotic + challenge, PC); (3) low dosage (4.0 × 10⁸ CFU/chick + challenge, LOW); and (4) high dosage (2.0 × 10⁹ CFU/chick + challenge, HIGH). On d5, groups two through four were challenged with Staphylococcus aureus through the drinking water at a concentration of 1.0 × 10⁵ CFU/mL. Cumulative lameness incidence was determined through daily evaluations and necropsies conducted on lame birds starting from d22. Data were subjected to a binomial general regression analysis (significant p < 0.05). On d56, the PC group exhibited the highest cumulative lameness incidence (58.0%; p < 0.05), followed by LOW (36.0%), HIGH (28.7%), and NC groups (25.3%), respectively. These results suggest early probiotic application at day-of-hatch successfully reduced the incidence of lameness in challenged birds, thus contributing to understanding of efficient and sustainable broiler production. Full article

In order to improve the pseudocapacitance performance of metal sulfide electrode materials and obtain supercapacitor energy storage devices with excellent electrochemical reversibility and long-term cycle stability, the synthesis of flower-shaped crystal nickel–cobalt sulfide and its supercapacitor performance were studied. NiCo₂S₄ flower-shaped crystal nickel–cobalt sulfide was prepared by the hydrothermal method with nickel foam as the raw material, and electrode materials were added to prepare supercapacitor electrodes for testing of the supercapacitor performance. The physical properties of flower-shaped crystal nickel–cobalt sulfide were tested by a scanning electron microscope and transmission electron microscope, and the voltammetric cycle and constant current charge and discharge of supercapacitor electrodes prepared from this sulfide were analyzed through experiments. The experimental results showed that the flower crystal microstructure had a positive effect on the electrochemical properties. The capacitance value was always high at different current densities, and the capacity was as high as 3867.8 A/g at pH 12. After 2000 voltage–charge–discharge cycle tests, the petal-like sulfide capacity still had a retention rate of 90.57, the flower crystal nickel–cobalt sulfide still showed an excellent supercapacitor performance and the specific capacity was still high, which demonstrates that this sulfide has excellent cyclic stability and durability in electrochemical applications. Full article

Angelica sinensis (Oliv.) Diels (A. sinensis) is a medicinal and edible values substance, which could promote blood circulation and enrich blood. It possesses rich chemical components and nutrients, which have significant therapeutic effects on cardiovascular and cerebrovascular diseases. It is commonly used for the prevention and treatment of cardiovascular and cerebrovascular diseases in the elderly, especially in improving ischemic damage to the heart and brain, protecting vascular cells, and regulating inflammatory reactions. This article reviews the main pharmacological effects and clinical research of A. sinensis on cardiovascular and cerebrovascular diseases in recent years, explores the effect of its chemical components on cardiovascular and cerebrovascular diseases by regulating the expression of functional proteins and inhibiting inflammation, anti-apoptosis, and antioxidant mechanisms. It provides a reference for further research on A. sinensis and the development of related drugs. It provides a new reference direction for the in-depth research and application of A. sinensis in the prevention, improvement, and treatment of cardiovascular and cerebrovascular diseases. Full article

In animal husbandry applications, segmenting live pigs in complex farming environments faces many challenges, such as when pigs lick railings and defecate within the acquisition environment. The pig’s behavior makes point cloud segmentation more complex because dynamic animal behaviors and environmental changes must be considered. This further requires point cloud segmentation algorithms to improve the feature capture capability. In order to tackle the challenges associated with accurately segmenting point cloud data collected in complex real-world scenarios, such as pig occlusion and posture changes, this study utilizes PointNet++. The SoftPool pooling method is employed to implement a PointNet++ model that can achieve accurate point cloud segmentation for live pigs in complex environments. Firstly, the PointNet++ model is modified to make it more suitable for pigs by adjusting its parameters related to feature extraction and sensory fields. Then, the model’s ability to capture the details of point cloud features is further improved by using SoftPool as the point cloud feature pooling method. Finally, registration, filtering, and extraction are used to preprocess the point clouds before integrating them into a dataset for manual annotation. The improved PointNet++ model’s segmentation ability was validated and redefined with the pig point cloud dataset. Through experiments, it was shown that the improved model has better learning ability across 529 pig point cloud data sets. The optimal mean Intersection over Union (mIoU) was recorded at 96.52% and the accuracy at 98.33%. This study has achieved the automatic segmentation of highly overlapping pigs and pen point clouds. This advancement enables future animal husbandry applications, such as estimating body weight and size based on 3D point clouds. Full article

Composite foundations have been widely used and promoted in practical engineering applications. However, research on the joint-bearing mechanism of piles and soil within composite foundations is still not comprehensive enough. This paper proposes a method for calculating the additional internal forces of piles and soil within composite foundations. Based on a three-dimensional finite element analysis, this study investigates the variation patterns of the stress, displacement, and additional internal forces of piles and soil in the depth direction under the action of upper loads when using friction piles and end-bearing piles. This research aims to reveal the bearing performance of piles and soil. The results showed that, under the same conditions and due to the presence of end-bearing effects, the internal forces experienced by the entire pile body of the end-bearing piles were more uniform, exhibiting significant advantages in resisting deformation and being able to withstand larger loads. Additionally, the diffusion mechanism of the vertical forces, stresses, and displacements of piles and soil is discussed. Due to the negative frictional resistance of soil and the influence of pile end-bearing effects, the distribution of internal forces and the displacements of piles and soil exhibited different characteristics. This study provides a scientific reference for the theoretical analysis and design of composite foundations. Full article

Purpose: We assess the application and advantages of modifying the trans-unco-discal (TUD) approach which we underwent for cervical myelo-radiculopathy. We present the surgical techniques of the modified TUD approach. Materials and Methods: The material was 180 cases where anterior cervical decompression (ACD) was performed by the modified TUD approach. We classified the material into four groups based on the location of the nerve root and/or spinal cord compression: I, compression of the root at intervertebral foramen (IVF); II, compression of the posterior margin of the vertebral body; III, compression of the IVF and posterior margin of the vertebral body; IV, compression of the bilateral IVF and posterior margin of the vertebral body. We applied the modified TUD approach to these four types. We present the surgical procedures and techniques for the modified TUD approach. The Japanese orthopedic association (JOA) score and neuroradiological alignment were examined. Results: The improvement rate of the JOA score was 78.4% at 6 months post-surgery and 77.5% in the most recent examinations. By the modified TUD approach, compressive lesions of the spinal cord and/or nerve roots were removed, and good alignment was acquired and sustained. Conclusions: ACD by the modified TUD approach safely achieved appropriate decompression for the spinal cord and/or nerve roots, and the patients had a high improvement rate and good alignment. Complications were less common than with other surgical procedures. If the TUD approach and endoscopic approaches can be combined, their application to new area is anticipated. Full article