The 2023 MDPI Annual Report has
been released!
 
28 pages, 7943 KiB  
Article
Systemic Risk and Bank Networks: A Use of Knowledge Graph with ChatGPT
by Ren-Yuan Lyu, Ren-Raw Chen, San-Lin Chung and Yilu Zhou
FinTech 2024, 3(2), 274-301; https://doi.org/10.3390/fintech3020016 (registering DOI) - 16 May 2024
Abstract
In this paper, we study the networks of financial institutions using textual data (i.e., news). We draw knowledge graphs after the textual data has been processed via various natural language processing and embedding methods, including use of the most recent version of ChatGPT [...] Read more.
In this paper, we study the networks of financial institutions using textual data (i.e., news). We draw knowledge graphs after the textual data has been processed via various natural language processing and embedding methods, including use of the most recent version of ChatGPT (via OpenAI api). Our final graphs represent bank networks and further shed light on the systemic risk of the financial institutions. Financial news reflects live how financial institutions are connected, via graphs which provide information on conditional dependencies among the financial institutions. Our results show that in the year 2016, the chosen 22 top U.S. financial firms are not closely connected and, hence, present no systemic risk. Full article
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8 pages, 2251 KiB  
Article
Mineralization of Octacalcium Phosphate under Magnetic Field
by Wenhao He, Bingyu Xue, Qi Qian, Shenye Chen, Zhengyi Fu and Kun Wang
Crystals 2024, 14(5), 463; https://doi.org/10.3390/cryst14050463 (registering DOI) - 16 May 2024
Abstract
The mineralization of octacalcium phosphate (OCP) crystals in gel media was studied in the presence of a magnetic field. OCP crystal growth was found to be dependent on mineralization temperature, mineralization time, and the magnetic field. Higher temperatures significantly reduced the mineralization time, [...] Read more.
The mineralization of octacalcium phosphate (OCP) crystals in gel media was studied in the presence of a magnetic field. OCP crystal growth was found to be dependent on mineralization temperature, mineralization time, and the magnetic field. Higher temperatures significantly reduced the mineralization time, which is crucial for directional growth of OCP crystals. The growth of OCP crystals was accelerated by the applied magnetic field, while OCP crystals generated in the presence of a magnetic field exhibited increased length and width of oriented growth. This study provides valuable insights into the influence of mineralization factors in bioprocessing-inspired manufacturing processes. Full article
(This article belongs to the Section Mineralogical Crystallography and Biomineralization)
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11 pages, 1005 KiB  
Article
The Incidence of Thyroid Cancer in Bethesda III Thyroid Nodules: A Retrospective Analysis at a Single Endocrine Surgery Center
by Iyad Hassan, Lina Hassan, Nahed Balalaa, Mohamad Askar, Hussa Alshehhi and Mohamad Almarzooqi
Diagnostics 2024, 14(10), 1026; https://doi.org/10.3390/diagnostics14101026 (registering DOI) - 16 May 2024
Abstract
Background: Fine-needle aspiration cytology (FNAC) is widely used to diagnose and monitor thyroid nodules. The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) is the standard for interpreting FNAC specimens. The risk of malignancy in Bethesda III nodules, also known as Atypia of Undetermined [...] Read more.
Background: Fine-needle aspiration cytology (FNAC) is widely used to diagnose and monitor thyroid nodules. The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) is the standard for interpreting FNAC specimens. The risk of malignancy in Bethesda III nodules, also known as Atypia of Undetermined Significance (AUS), varies significantly throughout several studies published worldwide. This retrospective study examines the risk of cancer in thyroid FNAC categorized as Bethesda III as identified in the final histopathology of thyroidectomy specimens at a single endocrine surgery center. Methods: This retrospective cohort analysis included 1038 consecutive patients who underwent elective thyroid surgery with complete follow-up data between January 2020 and March 2024. Preoperative data on clinical and pathological characteristics have been collected. The final histopathology report from the thyroidectomy specimen was compared to the results of the preoperative FNAC on nodules that were judged to be Bethesda category III. Statistical methods were performed using SPSS version 29. Results: A total of 670 ultrasound-guided FNACs (64.5%) performed during the study period were included in the final analysis. The study population was predominantly female, represented by 79.6% of patients with a mean age of 42.5 (SD 12.1), while 20.4% were male and significantly older with mean age of 45.13 years (p = 0.02). The FNAC inadequacy rate was 5.1%, which was associated with a high risk of malignancy (6 out of 34; 17.6%). Out of the total sample size of 170 patients classified as group III, 57 were found to have malignancies in final surgical histopathology, representing 33.5% of the cases within this category. The secondary gender-related outcome analysis showed that female patients classified under the Bethesda II category had a significantly higher risk of malignancy, with a rate of 21.2%, compared to males who had a malignancy rate of 3.4% in the same Bethesda category (p = 0.001, chi-square test). However, the female patients exhibited prognostically superior non-invasive tumors compared to male individuals (p = 0.02, chi-square test). Conclusion: This study’s results indicate that Bethesda categories II and III are associated with a higher risk of malignancy in comparison to the reports of the first and third editions of the TBSRTC, particularly for female patients classified under category II. Full article
(This article belongs to the Special Issue Cyto-Histological Correlations in Pathology Diagnosis)
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14 pages, 1195 KiB  
Article
Acute Kidney Injury in the Context of COVID-19: An Analysis in Hospitalized Mexican Patients
by Juan Carlos Borrego-Moreno, María Julieta Cárdenas-de Luna, José Carlos Márquez-Castillo, José Manuel Reyes-Ruiz, Juan Fidel Osuna-Ramos, Moisés León-Juárez, Rosa María del Ángel, Adrián Rodríguez-Carlos, Bruno Rivas-Santiago, Carlos Noe Farfan-Morales, Ana Cristina García-Herrera and Luis Adrián De Jesús-González
Infect. Dis. Rep. 2024, 16(3), 458-471; https://doi.org/10.3390/idr16030034 (registering DOI) - 16 May 2024
Abstract
During the COVID-19 pandemic, a considerable proportion of patients developed a severe condition that included respiratory failure, shock, or multiple organ dysfunction. Acute Kidney Injury (AKI) has been recognized as a possible cause of severe COVID-19 development. Given this, this study investigates the [...] Read more.
During the COVID-19 pandemic, a considerable proportion of patients developed a severe condition that included respiratory failure, shock, or multiple organ dysfunction. Acute Kidney Injury (AKI) has been recognized as a possible cause of severe COVID-19 development. Given this, this study investigates the occurrence and consequences of AKI in Mexican patients to contribute to better knowledge and management of this problem. Methods: Using a retrospective observational cohort methodology, we investigated 313 cases from a cohort of 1019 patients diagnosed with COVID-19 at the IMSS Zacatecas General Hospital of Zone No. 1 in 2020. The prevalence of AKI was determined using the AKIN criteria based on serum creatinine levels and a detailed review of demographic characteristics, medical history, comorbidities, and clinical development. Results: The data showed a 25.30% prevalence of AKI among patients infected with severe COVID-19. Remarkably, these patients with AKI exhibited an advanced age (>65 years), arterial hypertension, a higher number of white blood cells during admission and the hospital stay, and elevated levels of C-reactive protein, serum creatinine, and blood urea nitrogen (BUN). Clinically, patients with AKI had signs of prostration, pneumonia, and the requirement for ventilatory assistance when compared to those without AKI. Finally, those diagnosed with AKI and COVID-19 had a 74% death rate. Relative risk analyses indicated that age (>65 years), arterial hypertension, high creatinine levels, endotracheal intubation, and pneumonia are associated with the development of AKI. On the other hand, among the protective factors against AKI, high hemoglobin levels and the consumption of statins during COVID-19 were found. Conclusions: The findings of this study underscore the significance of promptly identifying and effectively managing AKI to potentially alleviate the negative consequences of this complication within the Mexican population during COVID-19. Full article
(This article belongs to the Section Infection Prevention and Control)
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13 pages, 4092 KiB  
Article
Photoperiod-Dependent Nutrient Accumulation in Rice Cultivated in Plant Factories: A Comparative Metabolomic Analysis
by Jingyao Yu, Yu Yang, Lanjun Luo, Fang Feng, Sana Saeed, Jie Luo, Chuanying Fang, Junjie Zhou and Kang Li
Foods 2024, 13(10), 1544; https://doi.org/10.3390/foods13101544 (registering DOI) - 16 May 2024
Abstract
Plant factories offer a promising solution to some of the challenges facing traditional agriculture, allowing for year-round rapid production of plant-derived foods. However, the effects of conditions in plant factories on metabolic nutrients remain to be explored. In this study, we used three [...] Read more.
Plant factories offer a promising solution to some of the challenges facing traditional agriculture, allowing for year-round rapid production of plant-derived foods. However, the effects of conditions in plant factories on metabolic nutrients remain to be explored. In this study, we used three rice accessions (KongYu131, HuangHuaZhan, and Kam Sweet Rice) as objectives, which were planted in a plant factory with strict photoperiods that are long-day (12 h light/12 h dark) or short-day (8 h light/16 h dark). A total of 438 metabolites were detected in the harvested rice grains. The difference in photoperiod leads to a different accumulation of metabolites in rice grains. Most metabolites accumulated significantly higher levels under the short-day condition than the long-day condition. Differentially accumulated metabolites were enriched in the amino acids and vitamin B6 pathway. Asparagine, pyridoxamine, and pyridoxine are key metabolites that accumulate at higher levels in rice grains harvested from the short-day photoperiod. This study reveals the photoperiod-dependent metabolomic differences in rice cultivated in plant factories, especially the metabolic profiling of taste- and nutrition-related compounds. Full article
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11 pages, 376 KiB  
Article
Prognostic Value of Fibrosis 4 (FIB-4) Index in Sepsis Patients
by Tuna Albayrak and Beyza Yuksel
J. Pers. Med. 2024, 14(5), 531; https://doi.org/10.3390/jpm14050531 (registering DOI) - 16 May 2024
Abstract
Background: Sepsis remains a major health challenge worldwide, characterized by a dysregulated host response to infection, leading to high mortality and morbidity in intensive care units (ICUs). The Fibrosis 4 (FIB-4) index, originally developed to assess liver fibrosis in hepatitis C patients, has [...] Read more.
Background: Sepsis remains a major health challenge worldwide, characterized by a dysregulated host response to infection, leading to high mortality and morbidity in intensive care units (ICUs). The Fibrosis 4 (FIB-4) index, originally developed to assess liver fibrosis in hepatitis C patients, has recently been explored for its potential prognostic value in sepsis patients. Method: this study retrospectively analyzed 309 sepsis patients admitted to the Internal Medicine and An-aesthesia ICUs between 12 December 2021 and 15 December 2023 to investigate the relationship between FIB-4 levels, the Acute Physiology and Chronic Health Evaluation (APACHE), the Sequential Organ Failure Assessment (SOFA), and clinical outcomes. Results: This study found that higher FIB-4 measurements were statistically significantly associated with increased 28-day mortality, with a cut-off value of 4.9, providing a sensitivity of 54.92% and specificity of 74.25%. Logistic regression analysis indicated that elevated FIB-4 levels were a significant predictor of early mortality, suggesting that the FIB-4 index could serve as a valuable prognostic tool in assessing the severity and prognosis of sepsis patients. Conclusions: by elucidating the potential role of the FIB-4 index in sepsis prognosis, this study contributes to the ongoing efforts to improve risk stratification and enhance patient care in sepsis management. Full article
(This article belongs to the Special Issue Personalized Medicine in the ICU—2nd Edition)
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18 pages, 252 KiB  
Article
Integrating Climate Change Risks and Sustainability Goals into Saudi Arabia’s Financial Regulation: Pathways to Green Finance
by Mohammad Omar Alhejaili
Sustainability 2024, 16(10), 4159; https://doi.org/10.3390/su16104159 (registering DOI) - 16 May 2024
Abstract
This study examines the integration of climate change risks and sustainability goals within Saudi Arabia’s financial regulatory framework to enhance green finance initiatives aligned with Vision 2030. A qualitative research design synthesises insights from a comprehensive literature review, semi-structured interviews with domain experts, [...] Read more.
This study examines the integration of climate change risks and sustainability goals within Saudi Arabia’s financial regulatory framework to enhance green finance initiatives aligned with Vision 2030. A qualitative research design synthesises insights from a comprehensive literature review, semi-structured interviews with domain experts, and a detailed analysis of critical Saudi green finance frameworks and legislation. This research identifies mechanisms for embedding sustainability in the financial sector and addresses the challenges, opportunities, and strategic directions essential for Saudi Arabia within the global context of sustainable finance. The findings reveal a robust foundation laid by Vision 2030 initiatives yet underscore the need for enhanced regulatory frameworks, increased market readiness, and greater societal engagement. This study highlights a significant literature gap in understanding Saudi Arabia’s unique approach to green finance amid its economic diversification and sustainability goals. Contributing to original insights, this research underscores the critical role of Saudi Arabia in the global energy market and its substantial economic and environmental transformations. It offers detailed analyses and recommendations that enrich the discourse on sustainable finance, impacting policymakers, financial practitioners, and scholars. Full article
(This article belongs to the Special Issue Green Finance, Economics and SDGs)
8 pages, 557 KiB  
Review
The Influence of Behavioral Sciences on Adherence to Physical Activity and Weight Loss in Overweight and Obese Patients: A Systematic Review of Randomized Controlled Trials
by Rafael Corrêa and Benjamin Miranda Tabak
Int. J. Environ. Res. Public Health 2024, 21(5), 630; https://doi.org/10.3390/ijerph21050630 (registering DOI) - 16 May 2024
Abstract
In recent years, weight gain and reduced physical activity in the general population have contributed to the development of obesity and other health problems; on the other hand, studies in behavioral sciences have been used to modify behaviors for a healthier life, so [...] Read more.
In recent years, weight gain and reduced physical activity in the general population have contributed to the development of obesity and other health problems; on the other hand, studies in behavioral sciences have been used to modify behaviors for a healthier life, so the objective of this study was to identify the evidence of interventions in behavioral sciences on adherence to physical activity and weight loss in obese patients. This systematic review study is based on a search of the electronic databases PubMed, Web of Science, Scopus, and Cochrane. Studies assessed the evidence from intervention studies that assessed the influence of intervention studies of behavioral sciences on public health. The articles were published between 2013 and 2023. The systematic search of the databases identified 2951 articles. The review analyzed 10 studies. Behavioral science interventions presented evidence through strategies such as multicomponent interventions, lottery and financial incentives, message framing, message framing with financial incentive and physical activity, and psychological satisfaction, demonstrating results in weight loss and maintenance and increased physical activity. This study presents scientific evidence through healthy behavior change methodologies, and future studies can explore these strategies in conjunction with public health technologies in the search for public–private partnerships to promote physical activity in adults. Full article
(This article belongs to the Special Issue Exercise and Physical Activity in Health Promotion)
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16 pages, 521 KiB  
Article
“I Thought It Was Beautiful; I Just Wish I Could Understand It”: The Awkward Dance of Multilingual Worship
by Marcell Silva Steuernagel
Religions 2024, 15(5), 611; https://doi.org/10.3390/rel15050611 (registering DOI) - 16 May 2024
Abstract
This article explores strategies for planning and leading multilingual worship. It offers an overview of translation and multilingualism for readers unfamiliar with the growing body of scholarship in these fields and connects them to the role of translation and multilingualism in Christian worship, [...] Read more.
This article explores strategies for planning and leading multilingual worship. It offers an overview of translation and multilingualism for readers unfamiliar with the growing body of scholarship in these fields and connects them to the role of translation and multilingualism in Christian worship, leveraging decolonial perspectives to critique its history. This article draws from a data set of approximately 40 liturgies designed for the Course of Study School of the United Methodist Church at Perkins School of Theology, Southern Methodist University. It uses selections from these liturgies to demonstrate how issues of translation and multilingualism might be dealt with in worship planning and leadership. Finally, the article points to possibilities for further exploration at the intersection between Christian worship and multilingualism. Full article
(This article belongs to the Special Issue Multilingualism in Religious Musical Practice)
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12 pages, 339 KiB  
Article
Mediatised Participation: Citizen Journalism and the Decline in User-Generated Content in Online News Media
by Simón Peña-Fernández, Ainara Larrondo-Ureta and Irati Agirreazkuenaga
Soc. Sci. 2024, 13(5), 266; https://doi.org/10.3390/socsci13050266 (registering DOI) - 16 May 2024
Abstract
The second generation of web tools shook the journalist profession approximately two decades ago with the proactive incorporation of audiences into the media. Citizen journalism and user-generated content arose as an object of interest due to the democratising value of participation attributed to [...] Read more.
The second generation of web tools shook the journalist profession approximately two decades ago with the proactive incorporation of audiences into the media. Citizen journalism and user-generated content arose as an object of interest due to the democratising value of participation attributed to them, with empowered citizens who could emulate the professional and institutional practises of journalists. However, difficulties soon came to the surface, and audience participation in news media began to be limited. Within this context, this article conducts a critical review of studies on audience participation in news media based on a systematic literature review. The results indicate that, in general, audiences showed low interest in the creation of informative content and that their participation has grown increasingly problematic. In addition, journalists are reticent as they defend their professional role above all else, while company strategies have prioritised making participation profitable. For this reason, the idea of citizen journalism that offers user-created content through the media appears to be a thing of the past, with many characteristics that could define it as a failed innovation. Therefore, the text concludes that audience participation in the media could be defined as mediatised participation. Full article
(This article belongs to the Special Issue Contemporary Digital Journalism: Issues and Challenges)
11 pages, 7293 KiB  
Article
An Elbow Patch Reconstruction Technique for Narrowed Remnant Portal Veins during Right Lobe Living Donor Hepatectomy: A Rescue Surgery
by Sertac Usta, Sami Akbulut, Kemal Baris Sarici, Ibrahim Umar Garzali, Fatih Ozdemir, Fatih Gonultas, Adil Baskiran, Burak Isik and Sezai Yilmaz
J. Clin. Med. 2024, 13(10), 2924; https://doi.org/10.3390/jcm13102924 (registering DOI) - 16 May 2024
Abstract
Background: Treatment of established portal vein narrowing after living donor hepatectomy is challenging. We aimed to present a new approach termed the “elbow patch reconstruction technique” to correct the narrowed remnant portal vein just or late after right lobe living donor hepatectomy. Methods: [...] Read more.
Background: Treatment of established portal vein narrowing after living donor hepatectomy is challenging. We aimed to present a new approach termed the “elbow patch reconstruction technique” to correct the narrowed remnant portal vein just or late after right lobe living donor hepatectomy. Methods: Demographic and clinical data of 12 living liver donors with narrowed remnant portal veins and treated with the “elbow patch reconstruction technique” were prospectively collected and retrospectively evaluated. Anatomic variation of the portal vein was defined in accordance with the Nakamura classification; six of the living liver donors had type A, three had type B, and the remaining three had type C. In eight of the living liver donors with a narrowed remnant portal vein, diagnosis was detected by intraoperative Doppler ultrasonography and visual inspection by experienced transplant surgeons in the living donor hepatectomy procedure. In the remaining four living liver donors, diagnosis was performed postoperatively when elevation of liver enzymes was noticed during the routine liver function test and Doppler US. The diagnosis was confirmed by multidetector computed tomography. Results: Data from nine males and three females aged 18 to 54 years were analyzed. All of the living liver donors were followed up for a median of 1710 days (min-max: 1178–4447 days; IQR: 1516 days), and none of the living liver donors had any structural or functional complications in the portal vein. Conclusions: Narrowing remnant portal veins are rare, but they are a life-threatening complication in living liver donors, and this condition requires urgent management. Image guided interventions and narrowed segment resection with end-to-end anastomosis using a vascular graft carried a potential risk for thrombosis and restenosis. To avoid these complications, we shared a technique named “elbow patch reconstruction technique”. This technique can be very effective in relieving the narrowing of the remnant portal vein after right lobe living donor hepatectomy. Full article
(This article belongs to the Section General Surgery)
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12 pages, 3086 KiB  
Article
Percutaneous Fluoroscopic-Guided Celiac Plexus Approach: Results in a Pig Cadaveric Model
by Francesco Aprea, Yolanda Millan, Anna Tomás, Gemma Sempere Campello, Rocio Navarrete Calvo and Maria del Mar Granados
Animals 2024, 14(10), 1478; https://doi.org/10.3390/ani14101478 (registering DOI) - 16 May 2024
Abstract
Celiac plexus block (CPB) and neurolysis (CPN) are used for pain management in people suffering from abdominal tumours or chronic pancreatitis. The fluoroscopically guided approach common in human medicine has not been described in veterinary settings. The aim of this study was to [...] Read more.
Celiac plexus block (CPB) and neurolysis (CPN) are used for pain management in people suffering from abdominal tumours or chronic pancreatitis. The fluoroscopically guided approach common in human medicine has not been described in veterinary settings. The aim of this study was to describe a fluoroscopic approach to the celiac plexus (CP) in fresh pig cadavers. Twelve animals were included in the procedure. Cadavers were positioned in sternal position and, under fluoroscopic guidance, a Chiba needle was inserted parasagittal at 6 cm from the spinal midline at the level of the last thoracic vertebra. From the left side, the needle was directed medio-ventrally with a 45° angle towards the T15 vertebral body; once the vertebral body was contacted, the needle was advanced 1 cm ventrally towards the midline. Iodinated contrast was injected to confirm the location. Following this, 2 mL of dye (China ink) was injected. A laparotomy was performed, and dyed tissue was dissected and prepared for both histochemical and immunohistochemical techniques. In 10 out of 12 samples submitted for histological evaluation, nervous tissue belonging to CP was observed. Fluoroscopy guidance allows for feasible access to the CP in swine cadavers in this study. Further studies are warranted to determine the efficacy of this technique in swine and other veterinary species. Full article
(This article belongs to the Special Issue Second Edition: Loco-Regional Anaesthesia in Veterinary Medicine)
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17 pages, 1238 KiB  
Article
Assessment of Adoption and Acceptance of Building Information Modeling for Building Construction among Industries in Qatar
by Louiesito S. Vitente, Ardvin Kester S. Ong and Josephine D. German
Buildings 2024, 14(5), 1433; https://doi.org/10.3390/buildings14051433 (registering DOI) - 16 May 2024
Abstract
Building information modeling (BIM) has become a vital tool in the construction industry, especially in Qatar, where remarkable infrastructural growth and innovation have taken place. This study looked into the factors influencing the adoption and acceptability of BIM in the Qatari construction industry [...] Read more.
Building information modeling (BIM) has become a vital tool in the construction industry, especially in Qatar, where remarkable infrastructural growth and innovation have taken place. This study looked into the factors influencing the adoption and acceptability of BIM in the Qatari construction industry using the Information System Success Model (ISSM), the Technology Acceptability Model (TAM), and structural equation modeling (SEM). Survey information gathered from project managers, contractors, engineers, architects, suppliers, and BIM specialists with direct BIM expertise was examined. The results showed that intentions to adopt BIM have a significant influence on its Perceived Usefulness and ease of use. The adoption of BIM is also significantly impacted by ISSM elements, including the Total Quality, Organizational Efficiency, Innovativeness, and Financial Aspects. This study illustrates the complex interactions between organizational influences and personal perspectives by demonstrating the direct and indirect effects of these factors on BIM adoption. These results provide a complete picture of the dynamics influencing BIM adoption in Qatar’s construction sector. As a result, this study makes connections between individual technology acceptance and the larger socio-technical environment of BIM implementation, providing essential information for building sector stakeholders, policymakers, and industry leaders. By using these insights to create strategies to boost BIM’s adoption and acceptability, the construction industries may be further aligned with global best practices in project management and delivery. Full article
(This article belongs to the Special Issue Building Information Management (BIM) toward Construction 5.0)
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10 pages, 3346 KiB  
Article
Correlation between CO2 Sensitivity and Channel-Layer Thickness in In2O3 Thin-Film Transistor Gas Sensors
by Ayumu Nodera, Ryota Kobayashi, Tsubasa Kobayashi and Shinya Aikawa
Electronics 2024, 13(10), 1947; https://doi.org/10.3390/electronics13101947 (registering DOI) - 16 May 2024
Abstract
CO2 monitoring is important for achieving net-zero emissions. Here, we report on a CO2 gas sensor based on an In2O3 thin-film transistor (TFT), which is expected to realize both low-temperature operation and high sensitivity. The effect of channel [...] Read more.
CO2 monitoring is important for achieving net-zero emissions. Here, we report on a CO2 gas sensor based on an In2O3 thin-film transistor (TFT), which is expected to realize both low-temperature operation and high sensitivity. The effect of channel thickness on TFT performance is well known; however, its effect on CO2 sensitivity has not been fully investigated. We fabricated In2O3 TFTs of various thicknesses to evaluate the effect of channel thickness on CO2 sensitivity. Consequently, TFT gas sensors with thinner channels exhibited higher CO2 sensitivity. This is because the surface effect is more prominent for a thinner film, suggesting that charge transfer between gas molecules and the channel surface through gas adsorption has a significant impact on changes in the TFT parameters in the subthreshold region. The results showed that the In2O3 TFT in thin channels is a promising candidate for CO2-sensitive TFT gas sensors and is useful for understanding an effect of gas adsorption in oxide TFTs with a very thin channel as well. Full article
(This article belongs to the Special Issue Feature Papers in Semiconductor Devices)
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4 pages, 1068 KiB  
Interesting Images
TAFRO Syndrome on 18F-FDG-PET/CT: An Appealing Diagnostic Tool
by Ayoub Jaafari, Nadim Taheri, Sohaïb Mansour, Saïf-Eddine El Bouhali and Rachid Attou
Diagnostics 2024, 14(10), 1025; https://doi.org/10.3390/diagnostics14101025 (registering DOI) - 16 May 2024
Abstract
TAFRO syndrome (TS) is a recently recognized and heterogenous systemic disease characterized by a confluence of symptoms: thrombocytopenia (T), anasarca (A), fever (F), reticulin myelofibrosis (R), and organomegaly (O). First described in Japan in 2010, the pathogenesis remains unclear and includes various clinical [...] Read more.
TAFRO syndrome (TS) is a recently recognized and heterogenous systemic disease characterized by a confluence of symptoms: thrombocytopenia (T), anasarca (A), fever (F), reticulin myelofibrosis (R), and organomegaly (O). First described in Japan in 2010, the pathogenesis remains unclear and includes various clinical conditions such as malignancies, rheumatologic disorders, infections, and “Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal plasma cell disorder, and Skin changes” (POEMS) syndrome. Due to its heterogeneous presentation and potential life-threatening delays in diagnosis, accurate diagnosis is crucial. According to the literature, no specific imaging modality has been recommended for the work-up of patients with suspected TS. Here, we report a case of TS and its management using 18F-FDG-PET/CT imaging as an attractive complementary diagnostic tool. Full article
(This article belongs to the Section Medical Imaging and Theranostics)
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17 pages, 5850 KiB  
Article
Regulatory Mechanisms of Pollen Development: Transcriptomic and Bioinformatic Insights into the Role of β-1,3 Glucanase Gene (LbGlu1) in Lycium barbarum
by Xin Zhang, Zhanlin Bei, Jinglong Li, Haijun Ma, Cuiping Wang, Wendi Xu, Yufeng Ren, Jun Zhou and Xingfu Yan
Horticulturae 2024, 10(5), 512; https://doi.org/10.3390/horticulturae10050512 (registering DOI) - 16 May 2024
Abstract
Pollen fertility is a critical factor in seed development and crop breeding. Extensive studies have explored the mechanisms of pollen fertility in model plants and economic crops. However, the mechanisms of pollen abortion in medicinal and edible plants, including Lycium barbarum, remain [...] Read more.
Pollen fertility is a critical factor in seed development and crop breeding. Extensive studies have explored the mechanisms of pollen fertility in model plants and economic crops. However, the mechanisms of pollen abortion in medicinal and edible plants, including Lycium barbarum, remain elusive. This study utilized transcriptome analysis to identify key genes and regulatory networks implicated in pollen fertility in L. barbarum. The results demonstrated differential expression of 12,185 genes (DEGs) between the sterile and fertile lines, encompassing 489 genes that exhibited variation across the five stages of pollen development. Additionally, GO and KEGG enrichment analyses indicated that the DEGs were predominantly associated with energy metabolism, carbohydrate metabolism, and notably, hydrolase activity. Co-expression network analysis unveiled two modules intimately associated with fertility, each comprising 908 and 756 hub genes, incorporating β-1,3-glucanase genes (Glu) and co-expressed transcription factors (TFs). Phylogenetic analysis implied that LbGlu1 was a potential candidate gene implicated in regulating pollen abortion in L. barbarum. This work advances a novel understanding of pollen abortion in L. barbarum and offers theoretical support for the utilization of sterility genes to enhance crop improvement. Full article
(This article belongs to the Special Issue Horticultural Crops Genetics and Genomics)
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31 pages, 3619 KiB  
Article
The Holistic Advantage: Unified Quantitative Modeling for Less-Biased, In-Depth Insights into (Socio)Linguistic Variation
by Wilkinson Daniel Wong Gonzales
Languages 2024, 9(5), 182; https://doi.org/10.3390/languages9050182 (registering DOI) - 16 May 2024
Abstract
What happens when recognized and diverse conditioning factors of linguistic variation are omitted from analysis and/or are not analyzed under a single analytical procedure? This paper explores the consequences of such a choice on data interpretation and, consequently, (socio)linguistic theorization. Utilizing Twitter-style English [...] Read more.
What happens when recognized and diverse conditioning factors of linguistic variation are omitted from analysis and/or are not analyzed under a single analytical procedure? This paper explores the consequences of such a choice on data interpretation and, consequently, (socio)linguistic theorization. Utilizing Twitter-style English in the Philippines (EngPH) as a case study, I employ the Twitter Corpus of Philippine Englishes (TCOPE) primarily to investigate and elucidate variations in three morphosyntactic variables that have been previously examined using a piecemeal approach. I propose a holistic quantitative approach that incorporates documented linguistic, social, diachronic, and stylistic factors in a unified analysis. The paper illustrates the impacts of adopting this holistic approach through two statistical procedures: Bayesian regression modeling and Boruta feature selection with random forest modeling. In contrast to earlier research findings, my overall results reveal biases in non-unified quantitative analyses, where the confidence in the effects of certain factors diminishes in light of others during analysis. The adoption of a unified analysis or modeling also enhances the resolution at which variations have been examined in EngPH. For instance, it highlights that presumed ‘universals’, such as the hierarchy of linguistic > stylistic > diachronic > social factors in explaining variation in some domains, is contingent on the specific variable under examination. Overall, I argue that unified analyses reduce data distortion and introduce more nuanced interpretations and insights that are critical for establishing a well-grounded empirical theory of EngPH variation and language variation as a whole. Full article
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18 pages, 541 KiB  
Article
Based on Symmetric Jump Risk Market: Study on the Ruin Problem of a Risk Model with Liquid Reserves and Proportional Investment
by Chunwei Wang, Shujing Wang, Jiaen Xu and Shaohua Li
Symmetry 2024, 16(5), 612; https://doi.org/10.3390/sym16050612 - 15 May 2024
Abstract
In order to deal with complex risk scenarios involving claims, uncertainty, and investments, we consider the ruin problems in a compound Poisson risk model with liquid reserves and proportional investments and study the expected discounted penalty function under threshold dividend strategies. Firstly, the [...] Read more.
In order to deal with complex risk scenarios involving claims, uncertainty, and investments, we consider the ruin problems in a compound Poisson risk model with liquid reserves and proportional investments and study the expected discounted penalty function under threshold dividend strategies. Firstly, the integral differential equation of the expected discounted penalty function is derived. Secondly, since the closed-form solution of the equation cannot be obtained, a sinc method is used to obtain the numerical approximation solution of the equation. Finally, the feasibility and superiority of the sinc method are illustrated by error analysis. In addition, based on a symmetric jump risk market, we discuss the influence of some parameters on the ruin probability with some examples. This study can help actuaries develop more robust risk management strategies and ensure the long-term stability and profitability of insurance companies. It provides a theoretical basis for actuaries to carry out risk management. Full article
(This article belongs to the Section Mathematics)
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15 pages, 6936 KiB  
Article
Effect of Overheating on the Tensile Properties of Nickel-Based Superalloy GH4720Li
by Anqi Wang, Zhicheng Liu, Ruoyao Cui, Yangyang Wu, Di Zhang and Xiaogang Wang
Materials 2024, 17(10), 2351; https://doi.org/10.3390/ma17102351 - 15 May 2024
Abstract
Aero-engines can be exposed to One Engine Inoperative (OEI) conditions during service, and the resulting overheating effect may significantly impact their structural integrity and flight safety. This paper focuses on the influence of overheating on the microstructural evolution and tensile properties of the [...] Read more.
Aero-engines can be exposed to One Engine Inoperative (OEI) conditions during service, and the resulting overheating effect may significantly impact their structural integrity and flight safety. This paper focuses on the influence of overheating on the microstructural evolution and tensile properties of the GH4720Li alloy, a nickel-based polycrystalline superalloy commonly used in turbine disks. Based on the typical OEI operating conditions of a real aero-engine, a series of non-isothermal high-temperature tensile tests involving an OEI stage of 800 °C were conducted. The effects of OEI-induced overheating on the microstructure and tensile properties of the GH4720Li alloy were investigated. The results showed that, after OEI treatment, the primary γ′ phase in this alloy was partially dissolved. The GH4720Li superalloy also exhibited numerous microcracks at the grain boundaries, resulting in complex effects on its tensile properties. The alloy’s yield strength and ultimate tensile strength were slightly decreased, whereas its ductility decreased considerably. The OEI-induced embrittlement phenomenon was mainly caused by the non-uniform distribution of the tertiary γ′ phase within grains. The formation of microcracks nucleated at the interfaces between the primary γ′ precipitates and γ matrix phase was another key factor. Full article
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40 pages, 2668 KiB  
Article
Ethnomedicinal Plants and Herbal Preparations Used by Rural Communities in Tehsil Hajira (Poonch District of Azad Kashmir, Pakistan)
by Tahira Jabeen, Muhammad Shoaib Amjad, Khalid Ahmad, Rainer W. Bussmann, Huma Qureshi and Ivana Vitasović-Kosić
Plants 2024, 13(10), 1379; https://doi.org/10.3390/plants13101379 (registering DOI) - 15 May 2024
Abstract
The present study emphasizes the importance of documenting ethnomedicinal plants and herbal practices of the local rural communities of Tehsil Hajira (Pakistan). The aim was to document, explore and quantify the traditional ethnomedicinal knowledge. Ethnobotanical data were collected using semi-structured questionnaires and analyzed [...] Read more.
The present study emphasizes the importance of documenting ethnomedicinal plants and herbal practices of the local rural communities of Tehsil Hajira (Pakistan). The aim was to document, explore and quantify the traditional ethnomedicinal knowledge. Ethnobotanical data were collected using semi-structured questionnaires and analyzed using various quantitative indices. The results showed that 144 medicinal plant species from 70 families and 128 genera play an important role in herbal preparations. The most common type of preparation was powder (19.0%), followed by paste (16.7%), aqueous extract (15.7%), decoction (14.7%) and juice (11.0%). Fragaria nubicola (0.94) and Viola canescens (0.93) had the highest relative frequency of mention (RFC), while Berberis lycium (1.22) and Fragaria nubicola (1.18) had the highest use value (UV). Geranium wallichianum (85.5), Ligustrum lucidum (83) and Indigofera heterantha (71.5) were the most important species in the study area with the highest relative importance (RI) value. The diseases treated were categorized into 17 classes, with diseases of the digestive system and liver having the highest Informant Consensus Factor (ICF) value, followed by diseases of the oropharynx and musculoskeletal system. Important plants mentioned for the treatment of various diseases of the gastrointestinal tract are Zanthoxylum alatum, Berberis lycium, Mentha longifolia, Punica granatum, Rubus ellipticus and Viola canescens. New applications of rarely documented plants from this area are: Oxalis corniculata paste of the whole plant to treat vitiligo, Carthamus tinctorius flowers to treat chicken pox, Dioscorea deltoidea tuber powder to treat productive cough, Inula cappa root decoction to treat miscarriage, Habenaria digitata tuber juice for the treatment of fever, Viola canescens leaves and flowers for the treatment of sore throat and Achillea millefolium root and leaf juice for the treatment of pneumonia. These plants may contain interesting biochemical compounds and should be subjected to further pharmacological studies to develop new drugs. Traditional medicinal knowledge in the area under study is mainly limited to the elderly, traditional healers and midwives. Therefore, resource conservation strategies and future pharmacological studies are strongly recommended. Full article
(This article belongs to the Special Issue New Insights into Ethnobotany and Ethnoecology)
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14 pages, 7189 KiB  
Article
DNA Microarray and Bioinformatic Analysis Reveals the Potential of Whale Oil in Enhancing Hair Growth in a C57BL/6 Mice Dorsal Skin Model
by Junko Shibato, Fumiko Takenoya, Ai Kimura, Michio Yamashita, Satoshi Hirako, Randeep Rakwal and Seiji Shioda
Genes 2024, 15(5), 627; https://doi.org/10.3390/genes15050627 (registering DOI) - 15 May 2024
Abstract
Much research has been conducted to determine how hair regeneration is regulated, as this could provide therapeutic, cosmetic, and even psychological interventions for hair loss. The current study focused on the hair growth effect and effective utilization of fatty oil obtained from Bryde’s [...] Read more.
Much research has been conducted to determine how hair regeneration is regulated, as this could provide therapeutic, cosmetic, and even psychological interventions for hair loss. The current study focused on the hair growth effect and effective utilization of fatty oil obtained from Bryde’s whales through a high-throughput DNA microarray approach in conjunction with immunohistochemical observations. The research also examined the mechanisms and factors involved in hair growth. In an experiment using female C57BL/6J mice, the vehicle control group (VC: propylene glycol: ethanol: water), the positive control group (MXD: 3% minoxidil), and the experimental group (WO: 20% whale oil) were topically applied to the dorsal skin of the mouse. The results showed that 3% MXD and 20% WO were more effective than VC in promoting hair growth, especially 20% WO. Furthermore, in hematoxylin and eosin-stained dorsal skin tissue, an increase in the number of hair follicles and subcutaneous tissue thickness was observed with 20% WO. Whole-genome transcriptome analysis also confirmed increases for 20% WO in filaggrin (Flg), a gene related to skin barrier function; fibroblast growth factor 21 (Fgf21), which is involved in hair follicle development; and cysteine-rich secretory protein 1 (Crisp1), a candidate gene for alopecia areata. Furthermore, the results of KEGG pathway analysis indicated that 20% WO may have lower stress and inflammatory responses than 3% MXD. Therefore, WO is expected to be a safe hair growth agent. Full article
(This article belongs to the Section Molecular Genetics and Genomics)
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14 pages, 3841 KiB  
Article
Synthesis of Submicron CaCO3 Particles in 3D-Printed Microfluidic Chips Supporting Advection and Diffusion Mixing
by Ivan Reznik, Ekaterina Kolesova, Anna Pestereva, Konstantin Baranov, Yury Osin, Kirill Bogdanov, Jacobus Swart, Stanislav Moshkalev and Anna Orlova
Micromachines 2024, 15(5), 652; https://doi.org/10.3390/mi15050652 (registering DOI) - 15 May 2024
Abstract
Microfluidic technology provides a solution to the challenge of continuous CaCO3 particle synthesis. In this study, we utilized a 3D-printed microfluidic chip to synthesize CaCO3 micro- and nanoparticles in vaterite form. Our primary focus was on investigating a continuous one-phase synthesis [...] Read more.
Microfluidic technology provides a solution to the challenge of continuous CaCO3 particle synthesis. In this study, we utilized a 3D-printed microfluidic chip to synthesize CaCO3 micro- and nanoparticles in vaterite form. Our primary focus was on investigating a continuous one-phase synthesis method tailored for the crystallization of these particles. By employing a combination of confocal and scanning electron microscopy, along with Raman spectroscopy, we were able to thoroughly evaluate the synthesis efficiency. This evaluation included aspects such as particle size distribution, morphology, and polymorph composition. The results unveiled the existence of two distinct synthesis regimes within the 3D-printed microfluidic chips, which featured a channel cross-section of 2 mm2. In the first regime, which was characterized by chaotic advection, particles with an average diameter of around 2 μm were produced, thereby displaying a broad size distribution. Conversely, the second regime, marked by diffusion mixing, led to the synthesis of submicron particles (approximately 800–900 nm in diameter) and even nanosized particles (70–80 nm). This research significantly contributes valuable insights to both the understanding and optimization of microfluidic synthesis processes, particularly in achieving the controlled production of submicron and nanoscale particles. Full article
(This article belongs to the Special Issue Microfluidics and 3D Printing for Biomedical Applications)
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18 pages, 984 KiB  
Article
The Application of Probiotic Bacteria from Strawberry (Fragaria ananassa × Duch.) in the Fermentation of Strawberry Tree Fruit (Arbutus unedo L.) Extract
by Deni Kostelac, Filip Dolenec, Anica Bebek Markovinović, Ksenija Markov, Danijela Bursać Kovačević and Jadranka Frece
Microorganisms 2024, 12(5), 1000; https://doi.org/10.3390/microorganisms12051000 (registering DOI) - 15 May 2024
Abstract
The search for unexplored plant resources that would provide a good basis for the development of novel probiotic functional foods is rapidly increasing. In this context, the strawberry tree fruit (Arbutus unedo L.) is particularly interesting, as it is rich in numerous [...] Read more.
The search for unexplored plant resources that would provide a good basis for the development of novel probiotic functional foods is rapidly increasing. In this context, the strawberry tree fruit (Arbutus unedo L.) is particularly interesting, as it is rich in numerous antioxidant bioactive compounds that have been shown to be beneficial to health, but have not yet found industrial applications. In this work, the probiotic characterization of lactic acid bacteria strain Lactiplantibacillus plantarum DB2, isolated from strawberries (Fragaria ananassa × Duch.), was performed. The tested strain proved to be safe to use, displaying no antibiotic resistance or hemolytic activity. Due to its proven probiotic potential during simulated gastrointestinal transit, its antimicrobial activity, and its coaggregation with pathogens, it was selected for fermentation of an aqueous Arbutus unedo L. extract, which was subsequently microencapsulated and freeze-dried to extend its shelf life and preserve its functional properties. The antioxidant activity of the ferment obtained was maintained (80%), while after microencapsulation and freeze-drying, about 50% and 20% of the antioxidant activity was retained, respectively. In conclusion, this study demonstrates for the first time the application of probiotics isolated from strawberries in the fermentation of strawberry tree extract and monitors the antioxidant activity during post-fermentation formulation, paving the way for a potential industrial application of this underutilized plant. Full article
(This article belongs to the Special Issue Microorganisms in Functional Foods)
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