The 2023 MDPI Annual Report has
been released!
 
24 pages, 5210 KiB  
Article
Enhancing Semi-Supervised Few-Shot Hyperspectral Image Classification via Progressive Sample Selection
by Jiaguo Zhao, Junjie Zhang, Huaxi Huang and Jian Zhang
Remote Sens. 2024, 16(10), 1747; https://doi.org/10.3390/rs16101747 (registering DOI) - 15 May 2024
Abstract
Hyperspectral images (HSIs) provide valuable spatial–spectral information for ground analysis. However, in few-shot (FS) scenarios, the limited availability of training samples poses significant challenges in capturing the sample distribution under diverse environmental conditions. Semi-supervised learning has shown promise in exploring the distribution of [...] Read more.
Hyperspectral images (HSIs) provide valuable spatial–spectral information for ground analysis. However, in few-shot (FS) scenarios, the limited availability of training samples poses significant challenges in capturing the sample distribution under diverse environmental conditions. Semi-supervised learning has shown promise in exploring the distribution of unlabeled samples through pseudo-labels. Nonetheless, FS HSI classification encounters the issue of high intra-class spectral variability and inter-class spectral similarity, which often lead to the diffusion of unreliable pseudo-labels during the iterative process. In this paper, we propose a simple yet effective progressive pseudo-label selection strategy that leverages the spatial–spectral consistency of HSI pixel samples. By leveraging spatially aligned ground materials as connected regions with the same semantic and similar spectrum, pseudo-labeled samples were selected based on round-wise confidence scores. Samples within both spatially and semantically connected regions of FS samples were assigned pseudo-labels and joined subsequent training rounds. Moreover, considering the spatial positions of FS samples that may appear in diverse patterns, to fully utilize unlabeled samples that fall outside the neighborhood of FS samples but still belong to certain connected regions, we designed a matching active learning approach for expert annotation based on the temporal confidence difference. We identified samples with the highest training value in specific regions, utilizing the consistency between predictive labels and expert labels to decide whether to include the region or the sample itself in the subsequent semi-supervised iteration. Experiments on both classic and more recent HSI datasets demonstrated that the proposed base model achieved SOTA performance even with extremely rare labeled samples. Moreover, the extended version with active learning further enhances performance by involving limited additional annotation. Full article
(This article belongs to the Special Issue Deep Learning for Spectral-Spatial Hyperspectral Image Classification)
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17 pages, 1662 KiB  
Article
Decentralized Navigation with Optimality for Multiple Holonomic Agents in Simply Connected Workspaces
by Dimitrios Kotsinis and Charalampos P. Bechlioulis
Sensors 2024, 24(10), 3134; https://doi.org/10.3390/s24103134 (registering DOI) - 15 May 2024
Abstract
Multi-agent systems are utilized more often in the research community and industry, as they can complete tasks faster and more efficiently than single-agent systems. Therefore, in this paper, we are going to present an optimal approach to the multi-agent navigation problem in simply [...] Read more.
Multi-agent systems are utilized more often in the research community and industry, as they can complete tasks faster and more efficiently than single-agent systems. Therefore, in this paper, we are going to present an optimal approach to the multi-agent navigation problem in simply connected workspaces. The task involves each agent reaching its destination starting from an initial position and following an optimal collision-free trajectory. To achieve this, we design a decentralized control protocol, defined by a navigation function, where each agent is equipped with a navigation controller that resolves imminent safety conflicts with the others, as well as the workspace boundary, without requesting knowledge about the goal position of the other agents. Our approach is rendered sub-optimal, since each agent owns a predetermined optimal policy calculated by a novel off-policy iterative method. We use this method because the computational complexity of learning-based methods needed to calculate the global optimal solution becomes unrealistic as the number of agents increases. To achieve our goal, we examine how much the yielded sub-optimal trajectory deviates from the optimal one and how much time the multi-agent system needs to accomplish its task as we increase the number of agents. Finally, we compare our method results with a discrete centralized policy method, also known as a Multi-Agent Poli-RRT* algorithm, to demonstrate the validity of our method when it is attached to other research algorithms. Full article
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11 pages, 933 KiB  
Communication
Distinct Expression Profiles of Neuroblastoma-Associated mRNAs in Peripheral Blood and Bone Marrow of Non-High-Risk and High-Risk Neuroblastoma Patients
by Naoko Nakatani, Kaung Htet Nay Win, Cho Yee Mon, Tomoko Fujikawa, Suguru Uemura, Atsuro Saito, Toshiaki Ishida, Takeshi Mori, Daiichiro Hasegawa, Yoshiyuki Kosaka, Shotaro Inoue, Akihiro Nishimura, Nanako Nino, Akihiro Tamura, Nobuyuki Yamamoto, Kandai Nozu and Noriyuki Nishimura
Biology 2024, 13(5), 345; https://doi.org/10.3390/biology13050345 (registering DOI) - 15 May 2024
Abstract
Non-high-risk (non-HR) neuroblastoma (NB) patients have excellent outcomes, with more than a 90% survival rate, whereas HR NB patients expect less than a 50% survival rate. Metastatic disease is the principal cause of death among both non-HR and HR NB patients. Previous studies [...] Read more.
Non-high-risk (non-HR) neuroblastoma (NB) patients have excellent outcomes, with more than a 90% survival rate, whereas HR NB patients expect less than a 50% survival rate. Metastatic disease is the principal cause of death among both non-HR and HR NB patients. Previous studies have reported the significant but limited prognostic value of quantitative PCR (qPCR)-based assays, measuring overlapping but different sets of neuroblastoma-associated mRNAs (NB-mRNAs), to detect metastatic disease in both non-HR and HR patient samples. A droplet digital PCR (ddPCR)-based assay measuring seven NB-mRNAs (CRMP1, DBH, DDC, GAP43, ISL1, PHOX2B, and TH mRNAs) was recently developed and exhibited a better prognostic value for HR patient samples than qPCR-based assays. However, it remained to be tested on non-HR patient samples. In the present study, we employed the ddPCR-based assay to study peripheral blood (PB) and bone marrow (BM) samples collected at diagnosis from eight non-HR and eleven HR cases and characterized the expression profiles of NB-mRNAs. The most highly expressed NB-mRNAs in PB and BM differed between non-HR and HR cases, with the CRMP1 mRNA being predominant in non-HR cases and the GAP43 mRNA in HR cases. The levels of NB-mRNAs in PB and BM were 5 to 1000 times lower in non-HR cases than in HR cases. The PB to BM ratio of NB-mRNAs was 10 to 100 times higher in non-HR cases compared to HR cases. The present case series suggests that non-HR and HR NB patients have the distinct expression profiles of NB-mRNAs in their PB and BM. Full article
(This article belongs to the Section Cancer Biology)
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23 pages, 2979 KiB  
Article
Population Trend of Colonially Nesting Heron Species in Greece
by Savas Kazantzidis, Theodoros Naziridis, Evangelia Katrana, Nikolaos Bukas, Georgios Kazantzidis, Aristidis Christidis and Christos Astaras
Birds 2024, 5(2), 217-239; https://doi.org/10.3390/birds5020015 (registering DOI) - 15 May 2024
Abstract
Heron colonies are dynamic components of wetlands. Therefore, their systematic monitoring is important for the management of both birds and wetlands. During the period 1988–2018, we counted breeding pairs of seven colonial breeding heron species at 65 colonies across 37 wetlands in Greece. [...] Read more.
Heron colonies are dynamic components of wetlands. Therefore, their systematic monitoring is important for the management of both birds and wetlands. During the period 1988–2018, we counted breeding pairs of seven colonial breeding heron species at 65 colonies across 37 wetlands in Greece. We considered as annual variables of a population: (a) years since 1988, (b) Natura 2000 network inclusion, (c) protected area management authority overseeing, (d) wetland type (new or restored), and (e) new colonies (established after 2003). The Cattle Egret Bubulcus ibis and the Squacco Heron Ardeola ralloides had a positive breeding population trend. The Black-crowned Night Heron Nycticorax nycticorax, Little Egret Egretta garzetta, and Grey Heron Ardea cinerea had a negative trend, while the Purple Heron Ardea purpurea population was stable. The Great White Egret Ardea alba bred sporadically at only a few sites which precluded the evaluation of its population trend. The informative population variables differed among species, even of those at the same colony, which suggests trends are also affected by conditions at wintering grounds. The study highlights the need for the systematic monitoring of heron colonies and the protection of foraging/breeding areas in order to reverse the observed negative population trends. Full article
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17 pages, 3676 KiB  
Review
What Role Does Simulation Play in Sustainable Industrial Development?
by Julia Nazarejova and Vladimir Modrak
Processes 2024, 12(5), 1007; https://doi.org/10.3390/pr12051007 (registering DOI) - 15 May 2024
Abstract
Sustainability as a concept is present in most aspects of our everyday life, and industry is no exception. Likewise, there is no doubt that the necessity to produce goods in a sustainable way and to ensure that products are sustainable is gaining more [...] Read more.
Sustainability as a concept is present in most aspects of our everyday life, and industry is no exception. Likewise, there is no doubt that the necessity to produce goods in a sustainable way and to ensure that products are sustainable is gaining more and more attention from producers, customers, governments, and various organizations. Understandably, there are several ways to increase the sustainable development of industrial production. One effective tool is simulation, which can have a significant impact on improving environmental, economic, and social sustainability. This paper explores the role of simulation as a powerful scientific and engineering solution in advancing sustainability within industrial ecosystems. Its main scope is to map the existing literature on the usage of simulation as a supportive tool for achieving this goal. For this purpose, a bibliometric analysis was conducted, allowing for tailored insights into the use of simulation in sustainable production. Full article
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17 pages, 358 KiB  
Review
The Emerging Role of Human Gut Bacteria Extracellular Vesicles in Mental Disorders and Developing New Pharmaceuticals
by Effrosyni Louka and Vassiliki Lila Koumandou
Curr. Issues Mol. Biol. 2024, 46(5), 4751-4767; https://doi.org/10.3390/cimb46050286 (registering DOI) - 15 May 2024
Abstract
In recent years, further evidence has emerged regarding the involvement of extracellular vesicles in various human physiopathological conditions such as Alzheimer’s disease, Parkinson’s disease, irritable bowel syndrome, and mental disorders. The biogenesis and cargo of such vesicles may reveal their impact on human [...] Read more.
In recent years, further evidence has emerged regarding the involvement of extracellular vesicles in various human physiopathological conditions such as Alzheimer’s disease, Parkinson’s disease, irritable bowel syndrome, and mental disorders. The biogenesis and cargo of such vesicles may reveal their impact on human health nd disease and set the underpinnings for the development of novel chemical compounds and pharmaceuticals. In this review, we examine the link between bacteria-derived exosomes in the gastrointestinal tract and mental disorders, such as depression and anxiety disorders. Crucially, we focus on whether changes in the gut environment affect the human mental state or the other way around. Furthermore, the possibility of handling bacteria-derived exosomes as vectors of chemicals to treat such conditions is examined. Full article
(This article belongs to the Special Issue Exosomes and Extracellular Vesicles in Neuroprotection)
19 pages, 6305 KiB  
Article
Deep Reinforcement Learning-Based 3D Trajectory Planning for Cellular Connected UAV
by Xiang Liu, Weizhi Zhong, Xin Wang, Hongtao Duan, Zhenxiong Fan, Haowen Jin, Yang Huang and Zhipeng Lin
Drones 2024, 8(5), 199; https://doi.org/10.3390/drones8050199 (registering DOI) - 15 May 2024
Abstract
To address the issue of limited application scenarios associated with connectivity assurance based on two-dimensional (2D) trajectory planning, this paper proposes an improved deep reinforcement learning (DRL) -based three-dimensional (3D) trajectory planning method for cellular unmanned aerial vehicles (UAVs) communication. By considering the [...] Read more.
To address the issue of limited application scenarios associated with connectivity assurance based on two-dimensional (2D) trajectory planning, this paper proposes an improved deep reinforcement learning (DRL) -based three-dimensional (3D) trajectory planning method for cellular unmanned aerial vehicles (UAVs) communication. By considering the 3D space environment and integrating factors such as UAV mission completion time and connectivity, we develop an objective function for path optimization and utilize the advanced dueling double deep Q network (D3QN) to optimize it. Additionally, we introduce the prioritized experience replay (PER) mechanism to enhance learning efficiency and expedite convergence. In order to further aid in trajectory planning, our method incorporates a simultaneous navigation and radio mapping (SNARM) framework that generates simulated 3D radio maps and simulates flight processes by utilizing measurement signals from the UAV during flight, thereby reducing actual flight costs. The simulation results demonstrate that the proposed approach effectively enable UAVs to avoid weak coverage regions in space, thereby reducing the weighted sum of flight time and expected interruption time. Full article
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14 pages, 788 KiB  
Article
The Association between Cyberbullying Victimization and Depression among Children: A Moderated Mediation Model
by Kuai Song, Feng-Juan Zhou, Geng-Feng Niu, Cui-Ying Fan and Zong-Kui Zhou
Behav. Sci. 2024, 14(5), 414; https://doi.org/10.3390/bs14050414 (registering DOI) - 15 May 2024
Abstract
Cyberbullying victimization is becoming more prevalent and adversely affects mental health. This research explores the relationship between the two variables and the underlying mechanism, especially for children, as the impact of mental health in childhood might last a lifetime. Primary school students ( [...] Read more.
Cyberbullying victimization is becoming more prevalent and adversely affects mental health. This research explores the relationship between the two variables and the underlying mechanism, especially for children, as the impact of mental health in childhood might last a lifetime. Primary school students (N = 344; Mage = 9.90; 43.90% girls) completed self-report questionnaires regarding cyberbullying victimization, self-perceived social competence, optimism, and depression at school. Gender and grade were controlled as covariates. Depression was positively predicted by cyberbullying victimization, while self-perceived social competence played a partially mediating role. In addition, optimism directly and indirectly moderated the effects of cyberbullying victimization on depression. Specifically, the effects were stronger for children with low levels of optimism. Therefore, efforts to enhance children’s self-perceived social competence and optimism may reduce their depression resulting from cyberbullying victimization. Full article
(This article belongs to the Section Child and Adolescent Psychiatry)
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16 pages, 1033 KiB  
Review
Exploring the Complex Interplay of Obesity, Allergic Diseases, and Sleep-Disordered Breathing in Children
by Chiara Voltan, Francesca Concer, Luca Pecoraro, Angelo Pietrobelli, Giorgio Piacentini and Marco Zaffanello
Children 2024, 11(5), 595; https://doi.org/10.3390/children11050595 (registering DOI) - 15 May 2024
Abstract
This narrative review study investigates the correlations between obesity, allergies, and sleep-disordered breathing in pediatric populations. Searches for pertinent articles were conducted on the Medline PubMed Advanced Search Builder, Scopus, and Web of Science databases from unlimited to April 2024. Sleep-disordered breathing causes [...] Read more.
This narrative review study investigates the correlations between obesity, allergies, and sleep-disordered breathing in pediatric populations. Searches for pertinent articles were conducted on the Medline PubMed Advanced Search Builder, Scopus, and Web of Science databases from unlimited to April 2024. Sleep-disordered breathing causes repeated upper airway obstructions, leading to apneas and restless sleep. Childhood obesity, which affects around 20% of children, is often associated with sleep-disordered breathing and allergies such as asthma and allergic rhinitis. It is distinguished between diet-induced obesity (resulting from excess of diet and physical inactivity) and genetic obesity (such as is seen in Down syndrome and Prader–Willi syndrome). In children with diet-induced obesity, chronic inflammation linked to weight can worsen allergies and increase the risk and severity of asthma and rhinitis. Furthermore, the nasal congestion typical of rhinitis can contribute to upper respiratory tract obstruction and obstructive sleep apnea. A vicious circle is created between asthma and sleep-disordered breathing: uncontrolled asthma and sleep-disordered breathing can worsen each other. In children with genetic obesity, despite alterations in the immune system, fewer allergies are observed compared to the broader population. The causes of this reduced allergenicity are unclear but probably involve genetic, immunological, and environmental factors. Additional research is necessary to elucidate the underlying mechanisms. The present narrative review study emphasizes the importance of jointly evaluating and managing allergies, obesity, and obstructive sleep apnea in children considering their close interconnection. Full article
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17 pages, 3160 KiB  
Article
Effect of Curcumin on Hepatic mRNA and lncRNA Co-Expression in Heat-Stressed Laying Hens
by Xinyue Wu, Xubin Du, Huifang Pian and Debing Yu
Int. J. Mol. Sci. 2024, 25(10), 5393; https://doi.org/10.3390/ijms25105393 (registering DOI) - 15 May 2024
Abstract
Heat stress is an important factor affecting poultry production; birds have a range of inflammatory reactions under high-temperature environments. Curcumin has anti-inflammatory and antioxidant effects. The purpose of this experiment was to investigate the effect of dietary curcumin supplementation on the liver transcriptome [...] Read more.
Heat stress is an important factor affecting poultry production; birds have a range of inflammatory reactions under high-temperature environments. Curcumin has anti-inflammatory and antioxidant effects. The purpose of this experiment was to investigate the effect of dietary curcumin supplementation on the liver transcriptome of laying hens under heat stress conditions. In the animal experiment, a total of 240 Hy-Line brown hens aged 280 days were divided randomly into four different experimental diets with four replicates, and each replicate consisted of 15 hens during a 42-D experiment. The ambient temperature was adjusted to 34 ± 2 °C for 8 h per day, transiting to a range of 22 °C to 28 °C for the remaining 16 h. In the previous study of our lab, it was found that supplemental 150 mg/kg curcumin can improve production performance, antioxidant enzyme activity, and immune function in laying hens under heat stress. To further investigate the regulatory mechanism of curcumin on heat stress-related genes, in total, six samples of three liver tissues from each of 0 mg/kg and 150 mg/kg curcumin test groups were collected for RNA-seq analysis. In the transcriptome analysis, we reported for the first time that the genes related to heat stress of mRNA, such as HSPA8, HSPH1, HSPA2, and DNAJA4, were co-expressed with lncRNA such as XLOC010450, XLOC037987, XLOC053511, XLOC061207, and XLOC100318, and all of these genes are shown to be down-regulated. These findings provide a scientific basis for the possible benefits of dietary curcumin addition in heat-stressed laying hens. Full article
(This article belongs to the Section Bioactives and Nutraceuticals)
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14 pages, 3603 KiB  
Article
Xyloglucan–Cellulose Nanocrystals Mixtures: A Case Study of Nanocolloidal Hydrogels and Levers for Tuning Functional Properties
by Géraldine Rangel, Céline Moreau, Ana Villares, Christophe Chassenieux and Bernard Cathala
Gels 2024, 10(5), 334; https://doi.org/10.3390/gels10050334 (registering DOI) - 15 May 2024
Abstract
The development of fully biobased hydrogels obtained by simple routes and in the absence of toxic or environmentally harmful reagents is a major challenge in meeting new societal demands. In this work, we discuss the development of hydrogels made from cellulose nanocrystals (CNCs) [...] Read more.
The development of fully biobased hydrogels obtained by simple routes and in the absence of toxic or environmentally harmful reagents is a major challenge in meeting new societal demands. In this work, we discuss the development of hydrogels made from cellulose nanocrystals (CNCs) and xyloglucan (XG), two non-toxic, renewable, and biobased components. We present three strategies to fine-tune the functional properties. The first one consists in varying the XG/CNC ratio that leads to the modulation of the mechanical properties of hydrogels as well as a better comprehension of the gel mechanism formation. The second relies on tuning the XG chains’ interaction by enzymatic modification to achieve thermoresponsive systems. Finally, the third one is based on the increase in the hydrogel solid content by osmotic concentration. The high-solid-content gels were found to have very high mechanical properties and self-healing properties that can be used for molding materials. Overall, these approaches are a case study of potential modifications and properties offered by biobased nanocolloidal hydrogels. Full article
(This article belongs to the Special Issue Cellulose-Based Gels: Synthesis, Properties, and Applications)
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21 pages, 461 KiB  
Article
EPSOM-Hyb: A General Purpose Estimator of Log-Marginal Likelihoods with Applications in Probabilistic Graphical Models
by Eric Chuu, Yabo Niu, Anirban Bhattacharya and Debdeep Pati
Algorithms 2024, 17(5), 213; https://doi.org/10.3390/a17050213 (registering DOI) - 15 May 2024
Abstract
We consider the estimation of the marginal likelihood in Bayesian statistics, with primary emphasis on Gaussian graphical models, where the intractability of the marginal likelihood in high dimensions is a frequently researched problem. We propose a general algorithm that can be widely applied [...] Read more.
We consider the estimation of the marginal likelihood in Bayesian statistics, with primary emphasis on Gaussian graphical models, where the intractability of the marginal likelihood in high dimensions is a frequently researched problem. We propose a general algorithm that can be widely applied to a variety of problem settings and excels particularly when dealing with near log-concave posteriors. Our method builds upon a previously posited algorithm that uses MCMC samples to partition the parameter space and forms piecewise constant approximations over these partition sets as a means of estimating the normalizing constant. In this paper, we refine the aforementioned local approximations by taking advantage of the shape of the target distribution and leveraging an expectation propagation algorithm to approximate Gaussian integrals over rectangular polytopes. Our numerical experiments show the versatility and accuracy of the proposed estimator, even as the parameter space increases in dimension and becomes more complicated. Full article
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4 pages, 147 KiB  
Editorial
Preface to the Special Issue on Computational Linguistics and Natural Language Processing
by Peter Z. Revesz
Information 2024, 15(5), 281; https://doi.org/10.3390/info15050281 (registering DOI) - 15 May 2024
Abstract
Computational linguistics and natural language processing are at the heart of the AI revolution that is currently transforming our lives [...] Full article
(This article belongs to the Special Issue Computational Linguistics and Natural Language Processing)
15 pages, 2808 KiB  
Article
Evaluation of Immunohistochemical Biomarkers in Diabetic Wistar Rats with Periodontal Disease
by Ioana Scrobota, Ioan Andrei Tig, Andrea Olivia Marcu, Georgiana Ioana Potra Cicalau, Liliana Sachelarie and Gilda Iova
J. Pers. Med. 2024, 14(5), 527; https://doi.org/10.3390/jpm14050527 (registering DOI) - 15 May 2024
Abstract
Background: The association of periodontal disease and diabetes is a subject of intense research in terms of etiopathology and treatment options. This research aimed to evaluate the modulation of the local inflammatory status by two natural extracts, curcumin (Cu) and rutin (R), in [...] Read more.
Background: The association of periodontal disease and diabetes is a subject of intense research in terms of etiopathology and treatment options. This research aimed to evaluate the modulation of the local inflammatory status by two natural extracts, curcumin (Cu) and rutin (R), in an experimentally induced diabetes and periodontal disease in Wistar rats. Methods: Fifty Wistar albino rats were randomly assigned to five groups: Control (C), Diabetes-associated Periodontal Disease (DP), Diabetes-associated Periodontal Disease treated with Curcumin (DPCu), Diabetes-associated Periodontal Disease treated with Rutin (DPR), and Diabetes-associated Periodontal Disease treated with both Curcumin and Rutin (DPCuR). Gingival samples were collected from all rats, and immunohistochemical markers CD3, CD20, and CD34 were evaluated to assess the local inflammatory infiltrate. Descriptive statistics were applied (SPSS24 Software, Armonk, NY, USA). Results: Rutin, alone or combined with Curcumin, reduced CD3-positive cell levels. Curcumin demonstrated superior efficacy in reducing CD20-positive cells. The combination of Curcumin and Rutin had the most important impact on both markers. Curcumin notably increased immature CD34-positive cell levels. Conclusions: Curcumin and Rutin, either alone or together, hold potential for reducing local inflammation in diabetes-induced periodontal disease in Wistar rats. Full article
(This article belongs to the Special Issue Recent Advances in Oral Diseases)
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26 pages, 2694 KiB  
Article
Study on the Evaluation of Urban Park Landscape Pattern Index and Its Driving Mechanisms in Nanchang City
by Xuechun Deng, Yuchen Zhou and Na Sun
Sustainability 2024, 16(10), 4132; https://doi.org/10.3390/su16104132 (registering DOI) - 15 May 2024
Abstract
Urban planning is often influenced by industrial and construction activities, leading to a lack of attention to the planning and construction of urban parks, which results in prominent spatial layout problems. Urban parks, as an important part of the urban green space system, [...] Read more.
Urban planning is often influenced by industrial and construction activities, leading to a lack of attention to the planning and construction of urban parks, which results in prominent spatial layout problems. Urban parks, as an important part of the urban green space system, play a significant role in improving the ecological environment, promoting urban economic development, and enhancing the daily living standards of the people. As a typical representative of China’s second and third-tier cities, Nanchang’s analysis of the evolution process of urban landscape patterns has reference significance for other similar cities in China. This paper is based on the theoretical foundations of landscape ecology, human geography, and urban planning, and analyzes the evolution of the park landscape pattern in the central urban area of Nanchang from 1999 to 2019 from the perspective of urban context, revealing the driving mechanisms. It provides important references and bases for the further optimization and construction development of the park landscape pattern in Nanchang. The results show that the park area and number in the central urban area of Nanchang have significantly increased, with the overall layout evolving from “central aggregation” to “core aggregation in each area”, and from “central scarcity, more on the periphery” to “inward concentration, outward diffusion”. However, the distribution of various types of parks is uneven, and there is a lack of green corridor links between parks. The park landscape pattern is driven by multiple factors such as natural factors of urban context, socio-economic factors, urban construction factors, historical policies, and related planning, which can have positive or negative effects. Incorporating relevant urban factors into the park planning system analysis can promote the benign development of urban context and park landscape layout, thereby achieving the “parkification” of the city. Full article
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19 pages, 10507 KiB  
Article
Triaxial Test and Discrete Element Numerical Simulation of Geogrid-Reinforced Clay Soil
by Xi Wang, Qizhi Hu, Yiming Liu and Gaoliang Tao
Buildings 2024, 14(5), 1422; https://doi.org/10.3390/buildings14051422 (registering DOI) - 15 May 2024
Abstract
Indoor triaxial tests on geogrid-reinforced clay elucidate the macroscopic changes in soil strength indices post-reinforcement, yet the underlying mechanisms of strength enhancement require further investigation. By conducting indoor triaxial tests and establishing a corresponding discrete element numerical model, we can delve into the [...] Read more.
Indoor triaxial tests on geogrid-reinforced clay elucidate the macroscopic changes in soil strength indices post-reinforcement, yet the underlying mechanisms of strength enhancement require further investigation. By conducting indoor triaxial tests and establishing a corresponding discrete element numerical model, we can delve into the fine-scale mechanisms of geogrid-reinforced soil. This includes analyzing changes in fine-scale parameters such as porosity, the coordination number, and contact stress between soil particles. The findings suggest that an increase in the number of geogrid reinforcement layers leads to a more pronounced improvement in peak strength and cohesion, albeit with minimal impact on the internal friction angle of the specimens. Furthermore, analysis of the triaxial test curves of reinforced soils indicates that the stress–strain relationship adheres to the Duncan–Chang model. Parameters derived from this model have been validated against experimental data, confirming their accuracy. The discrete element model was used to analyze the variations in fine-scale parameters such as porosity and coordination number. It revealed that reinforcement reduces the fluctuation amplitude of porosity and significantly increases the number of particle contacts, resulting in a denser soil structure. Further analysis of the change in contact stress between particles in the discrete element model revealed that the contact force between particles increased significantly after reinforcement and that the reinforcement played a role in restraining the soil particles and dispersing the reinforcement stress, which explains the increase in the strength of the mesh-reinforced clays from another perspective. This further elucidates the strength enhancement mechanism in geogrid-reinforced clay, offering a new perspective on the mechanical behavior and strength development of such materials. Full article
(This article belongs to the Section Building Energy, Physics, Environment, and Systems)
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19 pages, 4565 KiB  
Article
Novel Acetamide-Based HO-1 Inhibitor Counteracts Glioblastoma Progression by Interfering with the Hypoxic–Angiogenic Pathway
by Agata Grazia D’Amico, Grazia Maugeri, Luca Vanella, Valeria Consoli, Valeria Sorrenti, Francesca Bruno, Concetta Federico, Antonino Nicolò Fallica, Valeria Pittalà and Velia D’Agata
Int. J. Mol. Sci. 2024, 25(10), 5389; https://doi.org/10.3390/ijms25105389 (registering DOI) - 15 May 2024
Abstract
Glioblastoma multiforme (GBM) represents the deadliest tumor among brain cancers. It is a solid tumor characterized by uncontrolled cell proliferation generating the hypoxic niches in the cancer core. By inducing the transcription of hypoxic inducible factor (HIF), hypoxia triggers many signaling cascades responsible [...] Read more.
Glioblastoma multiforme (GBM) represents the deadliest tumor among brain cancers. It is a solid tumor characterized by uncontrolled cell proliferation generating the hypoxic niches in the cancer core. By inducing the transcription of hypoxic inducible factor (HIF), hypoxia triggers many signaling cascades responsible for cancer progression and aggressiveness, including enhanced expression of vascular endothelial growth factor (VEGF) or antioxidant enzymes, such as heme oxygenase-1 (HO-1). The present work aimed to investigate the link between HO-1 expression and the hypoxic microenvironment of GBM by culturing two human glioblastoma cell lines (U87MG and A172) in the presence of a hypoxic mimetic agent, deferoxamine (DFX). By targeting hypoxia-induced HO-1, we have tested the effect of a novel acetamide-based HO-1 inhibitor (VP18/58) on GBM progression. Results have demonstrated that hypoxic conditions induced upregulation and nuclear expression of HO-1 in a cell-dependent manner related to malignant phenotype. Moreover, our data demonstrated that the HO-1 inhibitor counteracted GBM progression by modulating the HIFα/HO-1/VEGF signaling cascade in cancer cells bearing more malignant phenotypes. Full article
(This article belongs to the Special Issue Molecular Progression of Genome-Related Diseases)
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23 pages, 5802 KiB  
Article
Assessing the Legibility of Arabic Road Signage Using Eye Gazing and Cognitive Loading Metrics
by Mohammad Lataifeh, Naveed Ahmed, Shaima Elbardawil and Somayeh Gordani
Computers 2024, 13(5), 123; https://doi.org/10.3390/computers13050123 (registering DOI) - 15 May 2024
Abstract
This research study aimed to evaluate the legibility of Arabic road signage using an eye-tracking approach within a virtual reality (VR) environment. The study was conducted in a controlled setting involving 20 participants who watched two videos using the HP Omnicept Reverb G2. [...] Read more.
This research study aimed to evaluate the legibility of Arabic road signage using an eye-tracking approach within a virtual reality (VR) environment. The study was conducted in a controlled setting involving 20 participants who watched two videos using the HP Omnicept Reverb G2. The VR device recorded eye gazing details in addition to other physiological data of the participants, providing an overlay of heart rate, eye movement, and cognitive load, which in combination were used to determine the participants’ focus during the experiment. The data were processed through a schematic design, and the final files were saved in .txt format, which was later used for data extraction and analysis. Through the execution of this study, it became apparent that employing eye-tracking technology within a VR setting offers a promising method for assessing the legibility of road signs. The outcomes of the current research enlightened the vital role of legibility in ensuring road safety and facilitating effective communication with drivers. Clear and easily comprehensible road signs were found to be pivotal in delivering timely information, aiding navigation, and ultimately mitigating accidents or confusion on the road. As a result, this study advocates for the utilization of VR as a valuable platform for enhancing the design and functionality of road signage systems, recognizing its potential to contribute significantly to the improvement of road safety and navigation for drivers. Full article
(This article belongs to the Special Issue Extended or Mixed Reality (AR + VR): Technology and Applications)
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18 pages, 6101 KiB  
Article
The Effect of Green Stormwater Infrastructures on Urban-Tier Human Thermal Comfort—A Case Study in High-Density Urban Blocks
by Haishun Xu, Jianhua Liao and Yating Hong
Forests 2024, 15(5), 862; https://doi.org/10.3390/f15050862 (registering DOI) - 15 May 2024
Abstract
Green stormwater infrastructure (GSI) is a key approach to greening and cooling high-density blocks. Previous studies have focused on the impact of a single GSI on thermal comfort on sunny days, ignoring rainwater’s role and GSI combinations. Therefore, based on measured data of [...] Read more.
Green stormwater infrastructure (GSI) is a key approach to greening and cooling high-density blocks. Previous studies have focused on the impact of a single GSI on thermal comfort on sunny days, ignoring rainwater’s role and GSI combinations. Therefore, based on measured data of a real urban area in Nanjing, China, this study utilized 45 single-GSI and combination simulation scenarios, as well as three local climate zone (LCZ) baseline scenarios to compare and analyze three high-density blocks within the city. Among the 32 simulations specifically conducted in LCZ1 and LCZ2, 2 of them were dedicated to baseline scenario simulations, whereas the remaining 30 simulations were evenly distributed across LCZ1 and LCZ2, with 15 simulations allocated to each zone. The physiological equivalent temperature (PET) was calculated using the ENVI-met specification to evaluate outdoor thermal comfort. The objective of this research was to determine the optimal GSI combinations for different LCZs, their impact on pedestrian thermal comfort, GSI response to rainwater, and the effect of GSI on pedestrian recreation areas. Results showed that GSI combinations are crucial for improving thermal comfort in compact high-rise and mid-rise areas, while a single GSI suffices in low-rise areas. In extreme heat, rainfall is vital for GSI’s effectiveness, and complex GSI can extend the thermal comfort improvement time following rainfall by more than 1 h. Adding shading and trees to GSI combinations maximizes thermal comfort in potential crowd activity areas, achieving up to 54.23% improvement. Future GSI construction in high-density blocks should focus on different combinations of GSI based on different LCZs, offering insights for GSI planning in Southeast Asia. Full article
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17 pages, 7523 KiB  
Article
In Vitro Evaluation of Mechanical, Surface, and Optical Properties of Restorative Materials Applied with Different Techniques
by Merve Nezir and Suat Özcan
J. Funct. Biomater. 2024, 15(5), 128; https://doi.org/10.3390/jfb15050128 (registering DOI) - 15 May 2024
Abstract
(1) Background: currently, the advantages of bulk-fill resin composite and high-viscosity glass ionomer materials have increased their use in dentistry; accordingly, their mechanical, surface, and optical properties have become more important. This study aimed to evaluate the mechanical, surface, and optical properties of [...] Read more.
(1) Background: currently, the advantages of bulk-fill resin composite and high-viscosity glass ionomer materials have increased their use in dentistry; accordingly, their mechanical, surface, and optical properties have become more important. This study aimed to evaluate the mechanical, surface, and optical properties of three different restorative materials (a high-viscosity bulk-fill resin composite (TNC), a flowable bulk-fill resin composite (EBF), and a high-viscosity glass ionomer (FIX)) after application using different techniques (control, heat application, and ultrasonic activation). (2) Methods: specimens were prepared to assess the color stability and surface roughness (n = 12). The specimens were immersed in two different solutions for 14 days. For the compressive strength test, specimens were prepared using a Teflon mold (n = 12). (3) Results: among the specimens applied according to the manufacturer’s instructions and immersed in distilled water, it was observed that the surface roughness values of FIX on the 7th day were statistically significantly higher than the other materials (p < 0.05). The compressive strength values of EBF applied using ultrasonic activation were significantly lower than those of EBF applied using the other techniques (p < 0.05). (4) Conclusions: coffee can negatively affect the color stability of restorative materials, but discoloration may vary depending on differences in the content of the material. All materials evaluated in this study exhibited clinically acceptable surface roughness values. It can be concluded that flowable bulk-fill resin composite is the most durable material in terms of compressive strength, so it can be used in the restoration of posterior teeth, especially those exposed to intensive stress. Full article
(This article belongs to the Section Dental Biomaterials)
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22 pages, 6656 KiB  
Article
Changes in Black Truffle (Tuber melanosporum) Aroma during Storage under Different Conditions
by Ruben Epping, Jan Lisec and Matthias Koch
J. Fungi 2024, 10(5), 354; https://doi.org/10.3390/jof10050354 (registering DOI) - 15 May 2024
Abstract
The enticing aroma of truffles is a key factor for their culinary value. Although all truffle species tend to be pricy, the most intensely aromatic species are the most sought after. Research into the aroma of truffles encompasses various disciplines including chemistry, biology, [...] Read more.
The enticing aroma of truffles is a key factor for their culinary value. Although all truffle species tend to be pricy, the most intensely aromatic species are the most sought after. Research into the aroma of truffles encompasses various disciplines including chemistry, biology, and sensory science. This study focusses on the chemical composition of the aroma of black truffles (Tuber melanosporum) and the changes occurring under different storage conditions. For this, truffle samples were stored under different treatments, at different temperatures, and measured over a total storage time of 12 days. Measurements of the truffle aroma profiles were taken with SPME/GC–MS at regular intervals. To handle the ample data collected, a systematic approach utilizing multivariate data analysis techniques was taken. This approach led to a vast amount of data which we made publicly available for future exploration. Results reveal the complexity of aroma changes, with 695 compounds identified, highlighting the need for a comprehensive understanding. Principal component analyses offer initial insights into truffle composition, while individual compounds may serve as markers for age (formic acid, 1-methylpropyl ester), freshness (2-Methyl-1-propanal; 1-(methylthio)-propane), freezing (tetrahydrofuran), salt treatment (1-chloropentane), or heat exposure (4-hydroxy-3-methyl-2-butanone). This research suggests that heat treatment or salt contact significantly affects truffle aroma, while freezing and cutting have less pronounced effects in comparison. The enrichment of compounds showing significant changes during storage was investigated with a metabolomic pathway analysis. The involvement of some of the enriched compounds on the pyruvate/glycolysis and sulfur pathways was shown. Full article
(This article belongs to the Special Issue New Perspectives on Tuber Fungi)
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21 pages, 4311 KiB  
Review
Biochar: From Laboratory to Industry Scale—An Overview of Scientific and Industrial Advances, Opportunities in the Brazilian Context, and Contributions to Sustainable Development
by Fernando Duarte Prochnow, Matheus Cavali, Aline Perin Dresch, Igor Marcon Belli, Nelson Libardi, Junior and Armando Borges de Castilhos, Junior
Processes 2024, 12(5), 1006; https://doi.org/10.3390/pr12051006 (registering DOI) - 15 May 2024
Abstract
Waste treatment and valorization have become crucial for sustainable development towards a circular economy. As an alternative, biochar production is a promising process to convert wastes into a valuable product that presents several potential applications to cope with environmental problems. Biochar in recent [...] Read more.
Waste treatment and valorization have become crucial for sustainable development towards a circular economy. As an alternative, biochar production is a promising process to convert wastes into a valuable product that presents several potential applications to cope with environmental problems. Biochar in recent years has been the subject of many studies, which have leveraged the number of patents and the industrial interest in this process. Against this background, this overview aimed: (i) to identify the advances in biochar research; (ii) to assess the number of patents on biochar over the years; (iii) to look at the industrial production of biochar worldwide; (iv) to detect the potential for biochar production in Brazil regarding waste biomass availability; and (v) to discuss the potential of biochar in contributing to reach some Sustainable Development Goals (SDGs). The holistic analysis presented here suggests that progress has been made in research, patent development, and industrial implementation of biochar, and that its potential role in achieving certain SDGs is noteworthy. Therefore, this overview can be useful in guiding future research about biochar to improve the knowledge of the different branches in this field. Full article
(This article belongs to the Special Issue High-Value Products from Biomass and Wastes)
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20 pages, 10406 KiB  
Article
A Simplified Model to Predict the Repeated Shear Strain during the Cyclic Triaxial Test by Using an Elastic Coefficient-Damping Ratio System
by Darn-Horng Hsiao, Yao-Wen Liang and Chia-Sheng Hsieh
Appl. Sci. 2024, 14(10), 4178; https://doi.org/10.3390/app14104178 (registering DOI) - 15 May 2024
Abstract
Some researchers in past years have tried to develop a simplified method for analyzing soil liquefaction. However, the correctness of the pore water pressure in the model will affect the results. In addition, the formulas derived are not easy, and the exact parameters [...] Read more.
Some researchers in past years have tried to develop a simplified method for analyzing soil liquefaction. However, the correctness of the pore water pressure in the model will affect the results. In addition, the formulas derived are not easy, and the exact parameters of the model are difficult to obtain. This study used a mass-spring-damping system to simulate the repeated strain of liquefaction cyclic triaxial tests. Because the model is simple and the parameters are easy to understand and obtain, it also shows the extensibility of this model. During the parameter study, damping coefficient c and spring coefficient k parameters decreased with the increasing cyclic number. Preliminary results of the research show that this model can further simulate the repeated strain obtained by cyclic triaxial tests without considering the variation of effective stress during cyclic loading. Four samples were used to verify the model’s correctness, and their boring sites were found in Yunlin areas, Taiwan. Simulation results show that the spring-damping system is feasible for simulated cyclic triaxial tests because the simulated results correlate to the testing results in trend. Generally, the first cycle number simulation will be less accurate because the pore water pressure of the specimen changes rapidly when the performance has just started. In contrast, the increase in subsequent cycles may be biased due to cyclic stress variation and soil plasticity during simulation. In the future, pure sand specimens created in the laboratory will be suggested for simulation. Full article
(This article belongs to the Special Issue Soil Liquefaction in Geotechnical Engineering)
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