The 2023 MDPI Annual Report has
been released!
 
22 pages, 13693 KiB  
Article
A New Insight into the Genesis of Graphite Deposits in Madagascar Using U‒Pb Zircon Dating and Electron Microprobe Analysis
by Ming-Jian Yang, Yong-Jun Di, Da Zhang, Da-Tian Wu, Ye Fang and Xin-Ming Zhang
Minerals 2024, 14(5), 484; https://doi.org/10.3390/min14050484 (registering DOI) - 02 May 2024
Abstract
Madagascar is globally recognized as an important producer of high-quality flaky graphite. However, current research on graphite deposits in Madagascar remains insufficient. Previous studies have linked the genesis of Madagascan graphite deposits to the metamorphism of sedimentary organic matter. Here, we provide a [...] Read more.
Madagascar is globally recognized as an important producer of high-quality flaky graphite. However, current research on graphite deposits in Madagascar remains insufficient. Previous studies have linked the genesis of Madagascan graphite deposits to the metamorphism of sedimentary organic matter. Here, we provide a case study of graphite deposits in Madagascar, combining new data from the Ambahita graphite deposit (AMG) in southern Madagascar with data from the Antanisoa graphite deposit (ANG) in central Madagascar and the Vohitasara graphite deposit (VOG) on the east coast of Madagascar. We note that the mineral assemblages of graphite-bearing rocks in the AMG, ANG, and VOG are not typical of metamorphic mineral assemblages but rather the results of filling and metasomatism by mantle-derived fluids that occurred after peak metamorphism. Electron microprobe analysis indicates that the graphite of the AMG, VOG, and ANG is usually associated with phlogopite or Mg-biotite; the phlogopite shares a common genesis with other widespread phlogopite deposits across Madagascar. We reveal that the distribution of graphite deposits in Madagascar is primarily controlled by ductile shear zones between blocks. Ductile shear zones that extend deep into the mantle can provide an ideal migration channel and architecture for the emplacement of mantle-derived fluids. The graphite mineralization formed no earlier than the peak metamorphism (490 Ma) and no later than the intrusion of pegmatite veins (389 ± 5 Ma). The distribution of graphite deposits, graphite orebody morphologies, mineral associations, and geochemical data suggest that the genesis of graphite deposits in Madagascar is linked to mantle-derived fluid filling rather than the metamorphism of sediments, as previously suggested. These findings have important implications for similar deposits in Madagascar and potentially globally. Full article
(This article belongs to the Special Issue Microbeam Analysis Characterization in Petrogenesis and Ore Deposit)
17 pages, 4187 KiB  
Article
Perpetuation of Gender Bias in Visual Representation of Professions in the Generative AI Tools DALL·E and Bing Image Creator
by Teresa Sandoval-Martin and Ester Martínez-Sanzo
Soc. Sci. 2024, 13(5), 250; https://doi.org/10.3390/socsci13050250 (registering DOI) - 02 May 2024
Abstract
Artificial intelligence (AI)-based generative imaging systems such as DALL·E, Midjourney, Stable Diffusion, and Adobe Firefly, which work by transforming natural language descriptions into images, are revolutionizing computer vision. In this exploratory and qualitative research, we have replicated requests for images of women in [...] Read more.
Artificial intelligence (AI)-based generative imaging systems such as DALL·E, Midjourney, Stable Diffusion, and Adobe Firefly, which work by transforming natural language descriptions into images, are revolutionizing computer vision. In this exploratory and qualitative research, we have replicated requests for images of women in different professions by comparing these representations in previous studies with DALL·E, observing that this model continues to provide in its last version, DALL·E 3, inequitable results in terms of gender. In addition, Bing Image Creator, Microsoft’s free tool that is widely used among the population and runs under DALL·E, has been tested for the first time. It also presents a sexualization of women and stereotypical children’s representations. The results reveal the following: 1. A slight improvement in terms of the presence of women in professions previously shown only with men. 2. They continue to offer biased results in terms of the objectification of women by showing sexualized women. 3. The representation of children highlights another level of gender bias, reinforcing traditional stereotypes associated with gender roles from childhood, which can impact future decisions regarding studies and occupations. Full article
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18 pages, 5757 KiB  
Review
Is Conduction System Pacing a Valuable Alternative to Biventricular Pacing for Cardiac Resynchronization Therapy?
by Davide Castagno, Francesco Zanon, Gianni Pastore, Gaetano Maria De Ferrari and Lina Marcantoni
J. Cardiovasc. Dev. Dis. 2024, 11(5), 144; https://doi.org/10.3390/jcdd11050144 (registering DOI) - 02 May 2024
Abstract
Cardiac resynchronization therapy (CRT) significantly improves clinical outcomes in patients with ventricular systolic dysfunction and dyssynchrony. Biventricular pacing (BVP) has a class IA recommendation for patients with symptomatic heart failure with reduced ejection fraction (HFrEF) and left bundle branch block (LBBB). However, approximately [...] Read more.
Cardiac resynchronization therapy (CRT) significantly improves clinical outcomes in patients with ventricular systolic dysfunction and dyssynchrony. Biventricular pacing (BVP) has a class IA recommendation for patients with symptomatic heart failure with reduced ejection fraction (HFrEF) and left bundle branch block (LBBB). However, approximately 30% of patients have a poor therapeutic response and do not achieve real clinical benefit. Pre-implant imaging, together with tailored programming and dedicated device algorithms, have been proposed as possible tools to improve success rate but have shown inconsistent results. Over the last few years, conduction system pacing (CSP) is becoming a real and attractive alternative to standard BVP as it can restore narrow QRS in patients with bundle branch block (BBB) by stimulating and recruiting the cardiac conduction system, thus ensuring true resynchronization. It includes His bundle pacing (HBP) and left bundle branch area pacing (LBBAP). Preliminary data coming from small single-center experiences are very promising and have laid the basis for currently ongoing randomized controlled trials comparing CSP with BVP. The purpose of this review is to delve into the emerging role of CSP as an alternative method of achieving CRT. After framing CSP in a historical perspective, the pathophysiological rationale and available clinical evidence will be examined, and crucial technical aspects will be discussed. Finally, evidence gaps and future perspectives on CSP as a technique of choice to deliver CRT will be summarized. Full article
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18 pages, 1959 KiB  
Review
Polymorphism of Genes Encoding Inflammatory Interleukins and the Risk of Anterior Cruciate Ligament Injury: A Systematic Review and Meta-Analysis
by Katarzyna Lorenz, Andrzej Mastalerz, Anna Cywińska, Aleksandra Garbacz and Ewelina Maculewicz
Int. J. Mol. Sci. 2024, 25(9), 4976; https://doi.org/10.3390/ijms25094976 (registering DOI) - 02 May 2024
Abstract
Sport injuries, including the anterior crucial ligament rupture (ACLR) seem to be related to complex genetic backgrounds, including the genes responsible for inflammatory response. This review and meta-analysis investigated the contribution of the polymorphisms of genes encoding inflammatory cytokines and their receptors to [...] Read more.
Sport injuries, including the anterior crucial ligament rupture (ACLR) seem to be related to complex genetic backgrounds, including the genes responsible for inflammatory response. This review and meta-analysis investigated the contribution of the polymorphisms of genes encoding inflammatory cytokines and their receptors to the risk of ACLR. The scientific databases Science Direct, EBSCO host, Scopus, PubMed, and Google Scholar were screened (completed on 14th June 2023) according to the established inclusion/exclusion criteria (only fully accessible, original, human case–control studies written in English concerning the effect of interleukin genes’ polymorphisms on the occurrence of ACL injury were included) and statistical meta-analysis using R version 4.0.3 was performed. The PRISMA methodology was used to review articles. The review protocol was registered under the number CRD42024514316 in the Prospero database. Eighty-nine studies were identified and narrowed down to three original case–control studies used for the meta-analysis. The studies analyzed Polish, South African, and Swedish cohorts, altogether 1282 participants. The candidate polymorphisms indicated in the studies involved IL6 rs1800795, IL6R rs2228145 and IL1B rs16944. The systematic review showed the relationships between IL6 rs1800795 polymorphism and ACLR in the Polish subpopulation, and IL6R rs2228145 and IL1B rs16944 in the South African subpopulations. The meta-analysis revealed that the IL6 rs1800795 CG genotype was over-represented (OR = 1.30, 95% CI 1.02–1.66), while the CC genotype was under-represented (OR = 0.75, 95% CI 0.54–1.03) in ACLR subjects, but no significant impact of IL6R rs2228145 was shown. Additionally, a tendency of the IL1B rs16944 CT genotype to be protective (OR 0.89, 95% CI 0.70–1.14), while the TT to be a risk genotype (OR 1.19, 95% CI 0.84–1.68) was observed. Thus, the relationship between the interleukin receptor IL6R rs2228145 and ACLR risk was not confirmed. however, the impact of genes coding pleiotropic IL6 rs1800795 on the incidences of ACLR was clear and the effect of pro-inflammatory IL1B rs16944 was possible. Full article
(This article belongs to the Special Issue The Role of Cytokines in Diseases)
20 pages, 4737 KiB  
Technical Note
Mud Spectral Characteristics from the Lusi Eruption, East Java, Indonesia Using Satellite Hyperspectral Data
by Stefania Amici, Maria Fabrizia Buongiorno, Alessandra Sciarra and Adriano Mazzini
Geosciences 2024, 14(5), 124; https://doi.org/10.3390/geosciences14050124 (registering DOI) - 02 May 2024
Abstract
Imaging spectroscopy allows us to identify surface materials by analyzing the spectra resulting from the light–material interaction. In this preliminary study, we analyze a pair of hyperspectral cubes acquired by PRISMA (on 20 April 2021) and EO1- Hyperion (on 4 July 2015) over [...] Read more.
Imaging spectroscopy allows us to identify surface materials by analyzing the spectra resulting from the light–material interaction. In this preliminary study, we analyze a pair of hyperspectral cubes acquired by PRISMA (on 20 April 2021) and EO1- Hyperion (on 4 July 2015) over the Indonesian Lusi mud eruption. We show the potential suitability of using the two sensors for characterizing the mineralogical features in demanding “wet and muddy” environments such as Lusi. We use spectral library reflectance spectra like Illite Chlorite from the USGS spectral library, which are known to be associated with Lusi volcanic products, to identify minerals. In addition, we have measured the reflectance spectra and composition of Lusi sampled mud collected in November 2014. Finally, we compare them with reflectance spectra from EO1-Hyperion and PRISMA. The use of hyperspectral sensors at improved SNR, such as PRISMA, has shown the potential to determine the mineral composition of Lusi PRISMA data, which allowed the distinction of areas with different turbidities as well. Artifacts in the VNIR spectral region of the L2 PRISMA reflectance product were found, suggesting that future work needs to take into account an independent atmospheric correction rather than using the L2D PRISMA product. Full article
(This article belongs to the Special Issue Remote Sensing Monitoring of Geomorphological Hazards)
23 pages, 10262 KiB  
Article
Experimental Study on Thermal Environment and Thermal Comfort of Passenger Compartment in Winter with Personal Comfort System
by Yuxin Hu, Lanping Zhao, Xin Xu, Guomin Wu and Zhigang Yang
Energies 2024, 17(9), 2190; https://doi.org/10.3390/en17092190 (registering DOI) - 02 May 2024
Abstract
The combined heating method of seat heating and air conditioning (A/C) was applied in the passenger compartment under different experiment conditions, using thermocouples to continuously measure the wall surfaces and air temperatures in the passenger compartment and the passengers’ skin temperatures of 17 [...] Read more.
The combined heating method of seat heating and air conditioning (A/C) was applied in the passenger compartment under different experiment conditions, using thermocouples to continuously measure the wall surfaces and air temperatures in the passenger compartment and the passengers’ skin temperatures of 17 segments. Meanwhile, a subjective evaluation questionnaire survey was conducted using a nine-point evaluation scale on the local and overall thermal sensation and thermal comfort of the passengers, and the data from the questionnaire were analyzed with the ANOVA method. The results showed that the use of the heating pad directly affected the changes in human skin temperature, which in turn affected the local and overall thermal sensation and thermal comfort. For the two thermally stimulated segments of the back and under the thighs, the skin temperature of the back was higher than that of the thighs. Using the heating pad resulted in a rapid increase in the mean skin temperature in the early period of the experiment. Thermal sensation of the back and under-thighs shifted rapidly towards the hot zone in the first 10 min, and then settled around +3, with even more significant differences between the groups. Thermal sensations in non-thermally stimulated segments changed in relation to their position on the heating pad, with slower changes in those at the “distal” end of the body, the head and the feet. Continued use of the heating pads at lower ambient temperatures maintained overall thermal comfort at a neutral level in the range of 0–1, whereas at higher ambient temperatures there was a gradual deterioration of local and overall thermal comfort. Full article
(This article belongs to the Section B: Energy and Environment)
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20 pages, 2658 KiB  
Article
Membrane Association of the Short Transglutaminase Type 2 Splice Variant (TG2-S) Modulates Cisplatin Resistance in a Human Hepatocellular Carcinoma (HepG2) Cell Line
by Dipak D. Meshram, Cristina Fanutti, Claire V. S. Pike and Peter J. Coussons
Curr. Issues Mol. Biol. 2024, 46(5), 4251-4270; https://doi.org/10.3390/cimb46050259 (registering DOI) - 02 May 2024
Abstract
Hepatocellular carcinoma (HCC) is a heterogeneous malignancy with complex carcinogenesis. Although there has been significant progress in the treatment of HCC over the past decades, drug resistance to chemotherapy remains a major obstacle in its successful management. In this study, we were able [...] Read more.
Hepatocellular carcinoma (HCC) is a heterogeneous malignancy with complex carcinogenesis. Although there has been significant progress in the treatment of HCC over the past decades, drug resistance to chemotherapy remains a major obstacle in its successful management. In this study, we were able to reduce chemoresistance in cisplatin-resistant HepG2 cells by either silencing the expression of transglutaminase type 2 (TG2) using siRNA or by the pre-treatment of cells with the TG2 enzyme inhibitor cystamine. Further analysis revealed that, whereas the full-length TG2 isoform (TG2-L) was almost completely cytoplasmic in its distribution, the majority of the short TG2 isoform (TG2-S) was membrane-associated in both parental and chemoresistant HepG2 cells. Following the induction of cisplatin toxicity in non-chemoresistant parental cells, TG2-S, together with cisplatin, quickly relocated to the cytosolic fraction. Conversely, no cytosolic relocalisation of TG2-S or nuclear accumulation cisplatin was observed, following the identical treatment of chemoresistant cells, where TG2-S remained predominantly membrane-associated. This suggests that the deficient subcellular relocalisation of TG2-S from membranous structures into the cytoplasm may limit the apoptic response to cisplatin toxicity in chemoresistant cells. Structural analysis of TG2 revealed the presence of binding motifs for interaction of TG2-S with the membrane scaffold protein LC3/LC3 homologue that could contribute to a novel mechanism of chemotherapeutic resistance in HepG2 cells Full article
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
20 pages, 2199 KiB  
Article
Organ-on-a-Chip: Ubi sumus? Fundamentals and Design Aspects
by Ana Sofia Morais, Maria Mendes, Marta Agostinho Cordeiro, João J. Sousa, Alberto Canelas Pais, Silvia M. Mihăilă and Carla Vitorino
Pharmaceutics 2024, 16(5), 615; https://doi.org/10.3390/pharmaceutics16050615 (registering DOI) - 02 May 2024
Abstract
This review outlines the evolutionary journey from traditional two-dimensional (2D) cell culture to the revolutionary field of organ-on-a-chip technology. Organ-on-a-chip technology integrates microfluidic systems to mimic the complex physiological environments of human organs, surpassing the limitations of conventional 2D cultures. This evolution has [...] Read more.
This review outlines the evolutionary journey from traditional two-dimensional (2D) cell culture to the revolutionary field of organ-on-a-chip technology. Organ-on-a-chip technology integrates microfluidic systems to mimic the complex physiological environments of human organs, surpassing the limitations of conventional 2D cultures. This evolution has opened new possibilities for understanding cell–cell interactions, cellular responses, drug screening, and disease modeling. However, the design and manufacture of microchips significantly influence their functionality, reliability, and applicability to different biomedical applications. Therefore, it is important to carefully consider design parameters, including the number of channels (single, double, or multi-channels), the channel shape, and the biological context. Simultaneously, the selection of appropriate materials compatible with the cells and fabrication methods optimize the chips’ capabilities for specific applications, mitigating some disadvantages associated with these systems. Furthermore, the success of organ-on-a-chip platforms greatly depends on the careful selection and utilization of cell resources. Advances in stem cell technology and tissue engineering have contributed to the availability of diverse cell sources, facilitating the development of more accurate and reliable organ-on-a-chip models. In conclusion, a holistic perspective of in vitro cellular modeling is provided, highlighting the integration of microfluidic technology and meticulous chip design, which play a pivotal role in replicating organ-specific microenvironments. At the same time, the sensible use of cell resources ensures the fidelity and applicability of these innovative platforms in several biomedical applications. Full article
(This article belongs to the Section Pharmaceutical Technology, Manufacturing and Devices)
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35 pages, 5505 KiB  
Review
Ecdysterone and Turkesterone—Compounds with Prominent Potential in Sport and Healthy Nutrition
by Velislava Todorova, Stanislava Ivanova, Dzhevdet Chakarov, Krasimir Kraev and Kalin Ivanov
Nutrients 2024, 16(9), 1382; https://doi.org/10.3390/nu16091382 (registering DOI) - 02 May 2024
Abstract
The naturally occurring compounds ecdysterone and turkesterone, which are present in plants, including Rhaponticum carthamoides Willd. (Iljin), Spinacia oleracea L., Chenopodium quinoa Willd., and Ajuga turkestanica (Regel) Briq, are widely recognized due to their possible advantages for both general health and athletic [...] Read more.
The naturally occurring compounds ecdysterone and turkesterone, which are present in plants, including Rhaponticum carthamoides Willd. (Iljin), Spinacia oleracea L., Chenopodium quinoa Willd., and Ajuga turkestanica (Regel) Briq, are widely recognized due to their possible advantages for both general health and athletic performance. The current review investigates the beneficial biological effects of ecdysterone and turkesterone in nutrition, highlighting their roles not only in enhancing athletic performance but also in the management of various health problems. Plant-based diets, associated with various health benefits and environmental sustainability, often include sources rich in phytoecdysteroids. However, the therapeutic potential of phytoecdysteroid-rich extracts extends beyond sports nutrition, with promising applications in treating chronic fatigue, cardiovascular diseases, and neurodegenerative disorders. Full article
(This article belongs to the Section Sports Nutrition)
14 pages, 5780 KiB  
Article
Exploring the Odd–Even Effect, Current Stabilization, and Negative Differential Resistance in Carbon-Chain-Based Molecular Devices
by Lijun Wang, Liping Zhou, Xuefeng Wang and Wenlong You
Electronics 2024, 13(9), 1764; https://doi.org/10.3390/electronics13091764 (registering DOI) - 02 May 2024
Abstract
The transport properties of molecular devices based on carbon chains are systematically investigated using a combination of non-equilibrium Green’s function (NEGF) and density functional theory (DFT) first-principle methods. In single-carbon-chain molecular devices, a distinct even–odd behavior of the current emerges, primarily influenced by [...] Read more.
The transport properties of molecular devices based on carbon chains are systematically investigated using a combination of non-equilibrium Green’s function (NEGF) and density functional theory (DFT) first-principle methods. In single-carbon-chain molecular devices, a distinct even–odd behavior of the current emerges, primarily influenced by the density of states (DOS) within the chain channel. Additionally, linear, monotonic currents exhibit Ohmic contact characteristics. In ladder-shaped carbon-chain molecular devices, a notable current stabilization behavior is observed, suggesting their potential utility as current stabilizers within circuits. We provide a comprehensive analysis of the transport properties of molecular devices featuring ladder-shaped carbon chains connecting benzene-ring molecules. The occurrence of negative differential resistance (NDR) in the low-bias voltage region is noted, with the possibility of manipulation by adjusting the position of the benzene-ring molecule. These findings offer a novel perspective on the potential applications of atom chains. Full article
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14 pages, 4656 KiB  
Article
Research on Hybrid Rectifier for High Power Electrolytic Hydrogen Production Based on Modular Multilevel Converter
by Cheng Huang, Yang Tan and Xin Meng
Energies 2024, 17(9), 2188; https://doi.org/10.3390/en17092188 (registering DOI) - 02 May 2024
Abstract
Aiming at the problem that silicon-controlled rectifiers (SCR) and pulse width modulation (PWM) rectifiers cannot balance high power levels, high hydrogen production efficiency, and high grid connected quality in the current research on rectifier power supplies for electrolytic hydrogen production, a new hybrid [...] Read more.
Aiming at the problem that silicon-controlled rectifiers (SCR) and pulse width modulation (PWM) rectifiers cannot balance high power levels, high hydrogen production efficiency, and high grid connected quality in the current research on rectifier power supplies for electrolytic hydrogen production, a new hybrid rectifier topology based on a modular multilevel converter (MMC) is proposed. The hybrid topology integrates a silicon-controlled rectifier (SCR) with an auxiliary power converter, wherein the SCR is designated as the primary power source for electrolytic hydrogen production. The auxiliary converter employs a cascaded modular multilevel converter (MMC) and an input-series-output-parallel (ISOP) phase-shifted full-bridge (PSFB) arrangement. This configuration allows the auxiliary converter to effectively mitigate AC-side harmonics and minimize DC-side ripple, concurrently transmitting a small amount of power. The effectiveness of the hybrid rectifier in achieving low ripple and harmonic distortion outputs was substantiated through hardware-in-the-loop experiments. Notably, the hybrid topology is characterized by its enhanced electric-to-hydrogen conversion efficiency, elevated power density, cost efficiency, and improved grid compatibility. Full article
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20 pages, 474 KiB  
Review
Shaping the Future of Healthcare: Integrating Ecology and Digital Innovation
by Domenico Bevere and Nicola Faccilongo
Sustainability 2024, 16(9), 3835; https://doi.org/10.3390/su16093835 (registering DOI) - 02 May 2024
Abstract
The concept of sustainable healthcare is the subject of an increasingly intense, captivating, forward-looking, yet sometimes still overly theoretical debate. The aim of this contribution is to analyze the current scenarios of ecological and digital transition in the healthcare sector, considering its high [...] Read more.
The concept of sustainable healthcare is the subject of an increasingly intense, captivating, forward-looking, yet sometimes still overly theoretical debate. The aim of this contribution is to analyze the current scenarios of ecological and digital transition in the healthcare sector, considering its high energy consumption. In particular, we adopt a holistic and convergent vision of the energy mix and its infrastructure, moving beyond the ideological dichotomy of energy sources. Renewable sources, digital innovations, and the circular economy are seen as playing key roles in the future of the energy sector. In this research, a mixed methodology was employed, combining a questionnaire consisting of 31 questions with semi-structured interviews conducted with the top management of a major player in the private healthcare sector located in southern Italy in 2023. Consequently, we examine the main macro-guidelines of technological development, encompassing enabling technologies, new business models, roles, and professional skills. Based on the analyses conducted, we provide some insights to inform governmental policies and industrial strategies in the near future. Digitalization represents an opportunity to enhance the efficiency of healthcare services, reducing waste and ensuring quality. For instance, digital healthcare solutions enable personalized care on a global scale and offer decision support systems that can enhance overall healthcare performance. However, to maximize the benefits of digital transformation, it is essential to integrate new technologies effectively and sustainably into the existing healthcare ecosystem. A promising example is telemedicine, which can help reduce carbon emissions by decreasing healthcare workers’ travel. Full article
(This article belongs to the Section Economic and Business Aspects of Sustainability)
19 pages, 649 KiB  
Article
A Comparative Study on Load Assessment Methods for Offshore Wind Turbines Using a Simplified Method and OpenFAST Simulations
by Satish Jawalageri, Subhamoy Bhattacharya, Soroosh Jalilvand and Abdollah Malekjafarian
Energies 2024, 17(9), 2189; https://doi.org/10.3390/en17092189 (registering DOI) - 02 May 2024
Abstract
Simplified methods are often used for load estimations during the initial design of the foundations of offshore wind turbines (OWTs). However, the reliability of simplified methods for designing different OWTs needs to be studied. This paper provides a comparative study to evaluate the [...] Read more.
Simplified methods are often used for load estimations during the initial design of the foundations of offshore wind turbines (OWTs). However, the reliability of simplified methods for designing different OWTs needs to be studied. This paper provides a comparative study to evaluate the reliability of simplified approaches. The foundation loads are calculated for OWTs at the mudline level using a simplified approach and OpenFAST simulations and compared. Three OWTs, NREL 5 MW, DTU 10 MW, and IEA 15 MW, are used as reference models. An Extreme Turbulence Model wind load at a rated wind speed, combined with a 50-year Extreme Wave Height (EWH) and Extreme Operating Gust (EOG) wind load and a 1-year maximum wave height are used as the load combinations in this study. In addition, the extreme loads are calculated using both approaches for various metocean data from five different wind farms. Further, the pile penetration lengths calculated using the mudline loads via two methods are compared. The results show that the simplified method provides conservative results for the estimated loads compared to the OpenFAST results, where the extent of conservativism is studied. For example, the bending moment and shear force at the mudline using the simplified approach are 23% to 69% and 32% to 53% higher compared to the OpenFAST results, respectively. In addition, the results show that the simplified approach can be effectively used during the initial phases of monopile foundation design by using factors such as 1.5 and 2 for the shear force and bending moment, respectively. Full article
(This article belongs to the Special Issue Offshore Wind Support Structure Design)
10 pages, 555 KiB  
Article
Unveiling the Knee Injury Landscape: A Comprehensive Study of Youth Male Football Players in the Central Region of Saudi Arabia
by Latifah Almansour, Walaa Sayed Mohammad, Walaa Elsais, Asma Alonazi and Danah Alyahya
Appl. Sci. 2024, 14(9), 3895; https://doi.org/10.3390/app14093895 (registering DOI) - 02 May 2024
Abstract
Knee injuries represent a significant health concern for young male football players in Saudi Arabia. Despite global research on football-related injuries, there is a distinct lack of studies focusing on this demographic in the Saudi context. This research aims to fill this gap, [...] Read more.
Knee injuries represent a significant health concern for young male football players in Saudi Arabia. Despite global research on football-related injuries, there is a distinct lack of studies focusing on this demographic in the Saudi context. This research aims to fill this gap, offering insights into injury prevalence and risk factors, thereby contributing to athlete well-being and informing tailored interventions. This study aimed to investigate the prevalence of knee injuries among youth male football players in Saudi Arabia, with a focus on injury patterns, risk factors, and associated factors. A cross-sectional study was conducted, involving 104 male football players who represent five Saudi clubs and are aged 18.82 ± 0.68 years. Injury data, including severity, timing, and mechanisms, were collected. Logistic regression analyses were performed to assess the impact of various factors on the likelihood of knee injuries. The study revealed that 37.5% of participants reported prior knee injuries, predominantly muscle injuries (61.5%) occurring during training. Ligamentous injuries, particularly anterior cruciate ligament injuries, were also notable (25.6%). Logistic regression analyses indicated that factors such as age, weight, height, body mass index, playing position, duration of playing football, and playing surface significantly influenced the odds of sustaining a knee injury. This study provides insights into the prevalence and patterns of knee injuries among youth male football players in the central region of Saudi Arabia. Muscle injuries are common. Factors such as age, weight, and playing position contribute to the risk of knee injuries. The findings underscore the need for targeted injury prevention strategies and player education programs. Full article
(This article belongs to the Section Applied Biosciences and Bioengineering)
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22 pages, 4285 KiB  
Article
Formal Analysis and Detection for ROS2 Communication Security Vulnerability
by Shuo Yang, Jian Guo and Xue Rui
Electronics 2024, 13(9), 1762; https://doi.org/10.3390/electronics13091762 (registering DOI) - 02 May 2024
Abstract
Robotic systems have been widely used in various industries, so the security of communication between robots and their components has become an issue that needs to be focused on. As a framework for developing robotic systems, the security of ROS2 (Robot Operating System [...] Read more.
Robotic systems have been widely used in various industries, so the security of communication between robots and their components has become an issue that needs to be focused on. As a framework for developing robotic systems, the security of ROS2 (Robot Operating System 2) can directly affect the security of the upper-level robotic systems. Therefore, it is a worthwhile research topic to detect and analyze the security of ROS2. In this study, we adopted a formal approach to analyze the security of the communication mechanism of ROS2. First, we used a state transition system to model the potential vulnerabilities of ROS2 based on the ROS2 communication mechanism and the basic process of penetration testing. Secondly, we introduced a CIA model based on the established vulnerability model and used linear temporal logic to define its security properties. Then, we designed and implemented a vulnerability detection tool for ROS2 applications based on the vulnerability model and security properties. Finally, we experimentally tested some ROS2-based applications, and the results show that ROS2 has vulnerabilities without additional protection safeguards. Full article
(This article belongs to the Special Issue Cybersecurity Issues in the Internet of Things)
20 pages, 11622 KiB  
Article
Actin Cytoskeleton Remodeling Accompanied by Redistribution of Adhesion Proteins Drives Migration of Cells in Different EMT States
by Alla S. Ilnitskaya, Nikita I. Litovka, Svetlana N. Rubtsova, Irina Y. Zhitnyak and Natalya A. Gloushankova
Cells 2024, 13(9), 780; https://doi.org/10.3390/cells13090780 (registering DOI) - 02 May 2024
Abstract
Epithelial–mesenchymal transition (EMT) is a process during which epithelial cells lose epithelial characteristics and gain mesenchymal features. Here, we used several cell models to study migratory activity and redistribution of cell–cell adhesion proteins in cells in different EMT states: EGF-induced EMT of epithelial [...] Read more.
Epithelial–mesenchymal transition (EMT) is a process during which epithelial cells lose epithelial characteristics and gain mesenchymal features. Here, we used several cell models to study migratory activity and redistribution of cell–cell adhesion proteins in cells in different EMT states: EGF-induced EMT of epithelial IAR-20 cells; IAR-6-1 cells with a hybrid epithelial–mesenchymal phenotype; and their more mesenchymal derivatives, IAR-6-1-DNE cells lacking adherens junctions. In migrating cells, the cell–cell adhesion protein α-catenin accumulated at the leading edges along with ArpC2/p34 and α-actinin. Suppression of α-catenin shifted cell morphology from fibroblast-like to discoid and attenuated cell migration. Expression of exogenous α-catenin in MDA-MB-468 cells devoid of α-catenin drastically increased their migratory capabilities. The Y654 phosphorylated form of β-catenin was detected at integrin adhesion complexes (IACs). Co-immunoprecipitation studies indicated that α-catenin and pY654-β-catenin were associated with IAC proteins: vinculin, zyxin, and α-actinin. Taken together, these data suggest that in cells undergoing EMT, catenins not participating in assembly of adherens junctions may affect cell migration. Full article
(This article belongs to the Special Issue Cytoskeletal Remodeling in Health and Disease)
15 pages, 12574 KiB  
Article
Electrochemical and Mechanical Properties of Hexagonal Titanium Dioxide Nanotubes Formed by Sonoelectrochemical Anodization
by Katarzyna Arkusz, Aleksandra Jędrzejewska, Piotr Siwak and Mieczysław Jurczyk
Materials 2024, 17(9), 2138; https://doi.org/10.3390/ma17092138 (registering DOI) - 02 May 2024
Abstract
This study aimed to investigate the fabrication and characterization of hexagonal titanium dioxide nanotubes (hTNTs) compared to compact TiO2 layers, focusing on their structural, electrochemical, corrosion, and mechanical properties. The fabrication process involved the sonoelectrochemical anodization of titanium foil in various electrolytes [...] Read more.
This study aimed to investigate the fabrication and characterization of hexagonal titanium dioxide nanotubes (hTNTs) compared to compact TiO2 layers, focusing on their structural, electrochemical, corrosion, and mechanical properties. The fabrication process involved the sonoelectrochemical anodization of titanium foil in various electrolytes to obtain titanium oxide layers with different morphologies. Scanning electron microscopy revealed the formation of well-ordered hexagonal TNTs with diagonals in the range of 30–95 nm and heights in the range of 3500–4000 nm (35,000–40,000 Å). The electrochemical measurements performed in 3.5% NaCl and Ringer’s solution confirmed a more positive open-circuit potential, a lower impedance, a higher electrical conductivity, and a higher corrosion rate of hTNTs compared to the compact TiO2. The data revealed a major drop in the impedance modulus of hTNTs, with a diagonal of 46 ± 8 nm by 97% in 3.5% NaCl and 96% in Ringer’s solution compared to the compact TiO2. Nanoindentation tests revealed that the mechanical properties of the hTNTs were influenced by their diagonal size, with decreasing hardness and Young’s modulus observed with an increasing diagonal size of the hTNTs, accompanied by increased plastic deformation. Overall, these findings suggest that hTNTs exhibit promising structural and electrochemical properties, making them potential candidates for various applications, including biosensor platforms. Full article
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15 pages, 1255 KiB  
Article
Selection of Appropriate Criteria for Optimization of Ventilation Element for Protective Clothing Using a Numerical Approach
by Sanjay Rajni Vejanand, Alexander Janushevskis and Ivo Vaicis
Computation 2024, 12(5), 90; https://doi.org/10.3390/computation12050090 (registering DOI) - 02 May 2024
Abstract
While there are multiple methods to ventilate protective clothing, there is still room for improvement. In our research, we are using ventilation elements that are positioned at the ventilation holes in the air space between the body and clothing. These ventilation elements allow [...] Read more.
While there are multiple methods to ventilate protective clothing, there is still room for improvement. In our research, we are using ventilation elements that are positioned at the ventilation holes in the air space between the body and clothing. These ventilation elements allow air to flow freely while preventing sun radiation, rain drops, and insects from directly accessing the body. Therefore, the shape of the ventilation element is crucial. This led us to study the shape optimization of ventilation elements through the utilization of metamodels and numerical approaches. In order to accomplish the objective, it is crucial to thoroughly evaluate and choose suitable criteria for the optimization process. We know from prior research that the toroidal cut-out shape element provides better results. In a previous study, we optimized the shape of this element based on the minimum pressure difference as a criterion. In this study, we are using different criteria for the shape optimization of ventilation elements to determine which are most effective. This study involves a metamodeling strategy that utilizes local and global approximations with different order polynomials, as well as Kriging approximations, for the purpose of optimizing the geometry of ventilation elements. The goal was achieved by a sequential process. (1) Planning the position of control points of Non-Uniform Rational B-Splines (NURBS) in order to generate elements with a smooth shape. (2) Constructing geometric CAD models based on the design of experiments. (3) Compute detailed model solutions using SolidWorks Flow Simulation. (4) Developing metamodels for responses using computer experiments. (5) Optimization of element shape using metamodels. The procedure is repeated for six criteria, and subsequently, the results are compared to determine the most efficient criteria for optimizing the design of the ventilation element. Full article
(This article belongs to the Section Computational Engineering)
18 pages, 15686 KiB  
Article
From Point Cloud to BIM: A New Method Based on Efficient Point Cloud Simplification by Geometric Feature Analysis and Building Parametric Objects in Rhinoceros/Grasshopper Software
by Massimiliano Pepe, Alfredo Restuccia Garofalo, Domenica Costantino, Federica Francesca Tana, Donato Palumbo, Vincenzo Saverio Alfio and Enrico Spacone
Remote Sens. 2024, 16(9), 1630; https://doi.org/10.3390/rs16091630 (registering DOI) - 02 May 2024
Abstract
The aim of the paper is to identify an efficient method for transforming the point cloud into parametric objects in the fields of architecture, engineering and construction by four main steps: 3D survey of the structure under investigation, generation of a new point [...] Read more.
The aim of the paper is to identify an efficient method for transforming the point cloud into parametric objects in the fields of architecture, engineering and construction by four main steps: 3D survey of the structure under investigation, generation of a new point cloud based on feature extraction and identification of suitable threshold values, geometry reconstruction by semi-automatic process performed in Rhinoceros/Grasshopper and BIM implementation. The developed method made it possible to quickly obtain geometries that were very realistic to the original ones as shown in the case study described in the paper. In particular, the application of ShrinkWrap algorithm on the simplify point cloud allowed us to obtain a polygonal mesh model without errors such as holes, non-manifold surfaces, compenetrating surfaces, etc. Full article
(This article belongs to the Special Issue Remote Sensing in Geomatics)
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15 pages, 3011 KiB  
Article
Recovery of Elemental Arsenic from Acidic As-Containing Wastewater by a Hypophosphite Reduction Process
by Qian Li, Shiyu Zhao, Yan Zhang, Yong Li, Xiaoliang Liu and Yongbin Yang
Water 2024, 16(9), 1301; https://doi.org/10.3390/w16091301 (registering DOI) - 02 May 2024
Abstract
Biological oxidation is a low-carbon technology for the treatment of As-containing gold ores, but it causes a large amount of acidic As-containing wastewater that is harmful to the environment. This paper proposed a novel, eco-friendly method to treat this wastewater. Thermodynamic analysis, H [...] Read more.
Biological oxidation is a low-carbon technology for the treatment of As-containing gold ores, but it causes a large amount of acidic As-containing wastewater that is harmful to the environment. This paper proposed a novel, eco-friendly method to treat this wastewater. Thermodynamic analysis, H2PO2 reduction, and wastewater recycling tests were conducted. Thermodynamic analysis indicates the feasibility of the reduction of As(V)/As(III) by H2PO2 or H3PO2 to As0 under acidic conditions. Experimental results confirmed the thermodynamic prediction and showed that H2PO2 could efficiently convert the As (i.e., As(V)/As(III)) in the wastewater to high value-added As0. Under the optimal conditions, 99.61% of As precipitated out, and the obtained As0 had a high purity of 98.5%. Kinetic results showed that the reaction order of H2PO2 concentration was 0.6399, and the activation energy of the H2PO2 reduction process was 34.33 kJ/mol, which is indicative of a mixed-controlled process (20–40 kJ/mol). Wastewater recycling results showed that after recovering As, the wastewater could be reused as a bacterial culture medium. Based on the thermodynamic analysis and experimental and analytical results, hypophosphite reduction mechanisms for removing and recovering As from its acidic wastewater were proposed. The results presented in this paper suggest the feasibility of this one-step H2PO2 reduction approach, which may be promising in treating acidic As-containing wastewater. Full article
(This article belongs to the Section Wastewater Treatment and Reuse)
22 pages, 931 KiB  
Article
A Hybrid MCDM Approach Using the BWM and the TOPSIS for a Financial Performance-Based Evaluation of Saudi Stocks
by Abdulrahman T. Alsanousi, Ammar Y. Alqahtani, Anas A. Makki and Majed A. Baghdadi
Information 2024, 15(5), 258; https://doi.org/10.3390/info15050258 (registering DOI) - 02 May 2024
Abstract
This study presents a hybrid multicriteria decision-making approach for evaluating stocks in the Saudi Stock Market. The objective is to provide investors and stakeholders with a robust evaluation methodology to inform their investment decisions. With a market value of USD 2.89 trillion dollars [...] Read more.
This study presents a hybrid multicriteria decision-making approach for evaluating stocks in the Saudi Stock Market. The objective is to provide investors and stakeholders with a robust evaluation methodology to inform their investment decisions. With a market value of USD 2.89 trillion dollars in September 2022, the Saudi Stock Market is of significant importance for the country’s economy. However, navigating the complexities of stock market performance poses investment challenges. This study employs the best–worst method and the technique for order preference by similarity to identify an ideal solution to address these challenges. Utilizing data from the Saudi Stock Market (Tadawul), this study evaluates stock performance based on financial criteria, including return on equity, return on assets, net profit margin, and asset turnover. The findings reveal valuable insights, particularly in the banking sector, which exhibited the highest net profit margin ratios among sectors. The hybrid multicriteria decision-making-based approach enhances investment decisions. This research provides a foundation for future investigations, facilitating a deeper exploration and analysis of additional aspects of the Saudi Stock Market’s performance. The developed methodology and findings have implications for investors and stakeholders, aiding their investment decisions and maximizing returns. Full article
(This article belongs to the Special Issue New Applications in Multiple Criteria Decision Analysis II)
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21 pages, 1088 KiB  
Article
The Case of Renewable Methane by and with Green Hydrogen as the Storage and Transport Medium for Intermittent Wind and Solar PV Energy
by John G. Ingersoll
Hydrogen 2024, 5(2), 209-229; https://doi.org/10.3390/hydrogen5020013 (registering DOI) - 02 May 2024
Abstract
Long-duration energy storage is the key challenge facing renewable energy transition in the future of well over 50% and up to 75% of primary energy supply with intermittent solar and wind electricity, while up to 25% would come from biomass, which requires traditional [...] Read more.
Long-duration energy storage is the key challenge facing renewable energy transition in the future of well over 50% and up to 75% of primary energy supply with intermittent solar and wind electricity, while up to 25% would come from biomass, which requires traditional type storage. To this end, chemical energy storage at grid scale in the form of fuel appears to be the ideal option for wind and solar power. Renewable hydrogen is a much-considered fuel along with ammonia. However, these fuels are not only difficult to transport over long distances, but they would also require totally new and prohibitively expensive infrastructure. On the other hand, the existing natural gas pipeline infrastructure in developed economies can not only transmit a mixture of methane with up to 20% hydrogen without modification, but it also has more than adequate long-duration storage capacity. This is confirmed by analyzing the energy economies of the USA and Germany, both possessing well-developed natural gas transmission and storage systems. It is envisioned that renewable methane will be produced via well-established biological and/or chemical processes reacting green hydrogen with carbon dioxide, the latter to be separated ideally from biogas generated via the biological conversion of biomass to biomethane. At the point of utilization of the methane to generate power and a variety of chemicals, the released carbon dioxide would be also sequestered. An essentially net zero carbon energy system would be then become operational. The current conversion efficiency of power to hydrogen/methane to power on the order of 40% would limit the penetration of wind and solar power. Conversion efficiencies of over 75% can be attained with the on-going commercialization of solid oxide electrolysis and fuel cells for up to 75% penetration of intermittent renewable power. The proposed hydrogen/methane system would then be widely adopted because it is practical, affordable, and sustainable. Full article
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24 pages, 6221 KiB  
Article
Assessing the Impact of Genotype-Specific Caprifig Fruit Storage on the Pollination Efficacy and Fruit Quality of “Bursa Siyahı” Cultivar: A Multivariate Analysis Approach
by Dilan Ahi Koşar and Ümran Ertürk
Agronomy 2024, 14(5), 958; https://doi.org/10.3390/agronomy14050958 (registering DOI) - 02 May 2024
Abstract
Fig types such as “Smyrna” and “San Pedro” require pollination (called caprification in fig cultivation) to produce a commercial crop, based on the crop and pollination characteristics of figs. Caprification is the process of hanging caprifig (male fig) fruits on female fig trees [...] Read more.
Fig types such as “Smyrna” and “San Pedro” require pollination (called caprification in fig cultivation) to produce a commercial crop, based on the crop and pollination characteristics of figs. Caprification is the process of hanging caprifig (male fig) fruits on female fig trees to ensure the transfer of pollen from the female fig to the caprifig by a wasp (Blastophaga psenes) that lives within the caprifig. It is necessary to extend the caprification period by using caprifig genotypes that ripen at different times, as female fig fruits ripen gradually. However, as caprifigs may not be continuously available for pollinating female figs, storing suitable caprifigs is necessary. The aim of this study was to assess changes in Blastophaga psenes, the duration of Blastophaga’s exit, and the viability of pollen from caprifigs of different genotypes (16 08 05, 16 08 09, 16 08 10, 16 09 10, and 16 ZF 08) stored for caprification. These stored caprifig genotypes were subsequently used for pollination three times at 8-day intervals, after which their impact on the set and quality of the edible fig fruits was evaluated. According to the average data, at the end of storage, the least B.psenes loss was obtained from the 16 08 05 (61.03%) genotype, and the highest was obtained from the 16 09 10 (67.00%) genotype. Pollen germination tended to increase with the storage of caprifig fruits, but this increase was not linear. After storage, the 16 08 09 and 16 09 10 genotypes exhibited greater pollen germination. The highest fruit set and quality were obtained when the 16 08 09 and 16 09 10 genotypes were used as pollen sources. Furthermore, since the 16 08 10 genotype is the latest ripening caprifig genotype, it has been determined that it can pollinate late-ripening “Bursa Siyahı” fruits. Principal component and path analysis demonstrated that pollen viability and germination rate were crucial in selecting caprifig genotypes for fruit set and quality. Full article
(This article belongs to the Special Issue Reproductive Biology of Mediterranean, Subtropical and Tropical Crops)

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