The 2023 MDPI Annual Report has
been released!
 
15 pages, 13835 KiB  
Article
Wdr17 Regulates Cell Proliferation, Cell Cycle Progression and Apoptosis in Mouse Spermatocyte Cell Line
by Xin Zhao, Taili Jin, Xi Ji, Qiuyan Zhang, Xianyu Zhang, Zhenfang Wu, Zicong Li and Huaqiang Yang
Animals 2024, 14(10), 1418; https://doi.org/10.3390/ani14101418 (registering DOI) - 9 May 2024
Abstract
We identified Wdr17 as a highly expressed gene in pachytene spermatocytes by transcriptomic analysis of mouse testis. Germ cell-deficient infertile mouse models had significantly reduced Wdr17 expression. We performed gene interference and overexpression in the mouse spermatocyte cell line GC-2spd(ts) and investigated how [...] Read more.
We identified Wdr17 as a highly expressed gene in pachytene spermatocytes by transcriptomic analysis of mouse testis. Germ cell-deficient infertile mouse models had significantly reduced Wdr17 expression. We performed gene interference and overexpression in the mouse spermatocyte cell line GC-2spd(ts) and investigated how Wdr17 affects spermatocyte growth and development. Our results showed that Wdr17 suppression significantly decreased cell growth rate and increased cell apoptosis in GC-2spd(ts) cells. Wdr17 suppression also arrested the cell cycle at the G1 phase. On the contrary, Wdr17 overexpression significantly promoted cell proliferation and inhibited cell apoptosis in GC-2spd(ts) cells. More cells were enriched at the S stage with a concomitant reduction of cells at the G1 stage. Wdr17 promotes mouse spermatocyte proliferation by advancing cell cycle progression and inhibiting cell apoptosis, indicating its potential role in regulating spermatogenesis in the mouse. Full article
(This article belongs to the Section Animal Reproduction)
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25 pages, 30056 KiB  
Article
Bio-Inspired Intelligent Swarm Confrontation Algorithm for a Complex Urban Scenario
by He Cai, Yaoguo Luo, Huanli Gao and Guangbin Wang
Electronics 2024, 13(10), 1848; https://doi.org/10.3390/electronics13101848 (registering DOI) - 9 May 2024
Abstract
This paper considers the confrontation problem for two tank swarms of equal size and capability in a complex urban scenario. Based on the Unity platform (2022.3.20f1c1), the confrontation scenario is constructed featuring multiple crossing roads. Through the analysis of a substantial amount of [...] Read more.
This paper considers the confrontation problem for two tank swarms of equal size and capability in a complex urban scenario. Based on the Unity platform (2022.3.20f1c1), the confrontation scenario is constructed featuring multiple crossing roads. Through the analysis of a substantial amount of biological data and wildlife videos regarding animal behavioral strategies during confrontations for hunting or food competition, two strategies are been utilized to design a novel bio-inspired intelligent swarm confrontation algorithm. The first one is the “fire concentration” strategy, which assigns a target for each tank in a way that the isolated opponent will be preferentially attacked with concentrated firepower. The second one is the “back and forth maneuver” strategy, which makes the tank tactically retreat after firing in order to avoid being hit when the shell is reloading. Two state-of-the-art swarm confrontation algorithms, namely the reinforcement learning algorithm and the assign nearest algorithm, are chosen as the opponents for the bio-inspired swarm confrontation algorithm proposed in this paper. Data of comprehensive confrontation tests show that the bio-inspired swarm confrontation algorithm has significant advantages over its opponents from the aspects of both win rate and efficiency. Moreover, we discuss how vital algorithm parameters would influence the performance indices. Full article
(This article belongs to the Topic Agents and Multi-Agent Systems)
14 pages, 585 KiB  
Article
Identification of Potential Therapeutics of Mentha Essential Oil Content as Antibacterial MDR Agents against AcrAB-TolC Multidrug Efflux Pump from Escherichia coli: An In Silico Exploration
by Rawaf Alenazy
Life 2024, 14(5), 610; https://doi.org/10.3390/life14050610 (registering DOI) - 9 May 2024
Abstract
Multidrug-resistant bacterial pathogens, such as E. coli, represent a major human health threat. Due to the critical need to overcome this dilemma, since the drug efflux pump has a vital function in the evolution of antimicrobial resistance in bacteria, we have investigated [...] Read more.
Multidrug-resistant bacterial pathogens, such as E. coli, represent a major human health threat. Due to the critical need to overcome this dilemma, since the drug efflux pump has a vital function in the evolution of antimicrobial resistance in bacteria, we have investigated the potential of Mentha essential oil major constituents (119) as antimicrobial agents via their ability to inhibit pathogenic DNA gyrase and, in addition, their potential inhibition of the E. coli AcrB-TolC efflux pump, a potential target to inhibit MDR pathogens. The ligand docking approach was conducted to analyze the binding interactions of Mentha EO constituents with the target receptors. The obtained results proved their antimicrobial activity through the inhibition of DNA gyrase (1kzn) with binding affinity ΔG values between −4.94 and −6.49 kcal/mol. Moreover, Mentha EO constituents demonstrated their activity against MDR E. coli by their ability to inhibit AcrB-TolC (4dx7) with ΔG values ranging between −4.69 and −6.39 kcal/mol. The antimicrobial and MDR activity of Mentha EOs was supported via hydrogen bonding and hydrophobic interactions with the key amino acid residues at the binding site of the active pocket of the targeted receptors. Full article
(This article belongs to the Topic Plant Extracts and Their Therapeutic Effects)
11 pages, 490 KiB  
Article
A Statistical and AI Analysis of the Frequency Spectrum in the Measurement of the Center of Pressure Track in the Seated Position in Healthy Subjects and Subjects with Low Back Pain CoP-T
by Jan Jens Koltermann, Philipp Floessel, Franziska Hammerschmidt and Alexander C. Disch
Sensors 2024, 24(10), 3011; https://doi.org/10.3390/s24103011 (registering DOI) - 9 May 2024
Abstract
Measuring postural control in an upright standing position is the standard method. However, this diagnostic method has floor or ceiling effects and its implementation is only possible to a limited extent. Assessing postural control directly on the trunk in a sitting position and [...] Read more.
Measuring postural control in an upright standing position is the standard method. However, this diagnostic method has floor or ceiling effects and its implementation is only possible to a limited extent. Assessing postural control directly on the trunk in a sitting position and consideration of the results in the spectrum in conjunction with an AI-supported evaluation could represent an alternative diagnostic method quantifying neuromuscular control. In a prospective cross-sectional study, 188 subjects aged between 18 and 60 years were recruited and divided into two groups: “LowBackPain” vs. “Healthy”. Subsequently, measurements of postural control in a seated position were carried out for 60 s using a modified balance board. A spectrum per trail was calculated using the measured CoP tracks in the range from 0.01 to 10 Hz. Various algorithms for data classification and prediction of these classes were tested for the parameter combination with the highest proven static influence on the parameter pain. The best results were found in a frequency spectrum of 0.001 Hz and greater than 1 Hz. After transforming the track from the time domain to the image domain for representation as power density, the influence of pain was highly significant (effect size 0.9). The link between pain and gender (p = 0.015) and pain and height (p = 0.012) also demonstrated significant results. The assessment of postural control in a seated position allows differentiation between “LowBackPain” and “Healthy” subjects. Using the AI algorithm of neural networks, the data set can be correctly differentiated into “LowBackPain” and “Healthy” with a probability of 81%. Full article
(This article belongs to the Special Issue Advanced Sensors in Biomechanics and Rehabilitation)
15 pages, 1104 KiB  
Article
Characterization of Culturable Mycobiome of Newly Excavated Ancient Wooden Vessels from the Archeological Site of Viminacium, Serbia
by Ivana Djokić, Aleksandar Knežević, Željko Savković, Milica Ljaljević Grbić, Ivica Dimkić, Danka Bukvički, Dragana Gavrilović and Nikola Unković
J. Fungi 2024, 10(5), 343; https://doi.org/10.3390/jof10050343 (registering DOI) - 9 May 2024
Abstract
Two ancient wooden vessels, specifically a monoxyle (1st century BCE to 1st century CE) and shipwreck (15th to 17th century CE), were excavated in a well-preserved state east of the confluence of the old Mlava and the Danube rivers (Serbia). The vessels were [...] Read more.
Two ancient wooden vessels, specifically a monoxyle (1st century BCE to 1st century CE) and shipwreck (15th to 17th century CE), were excavated in a well-preserved state east of the confluence of the old Mlava and the Danube rivers (Serbia). The vessels were found in the ground that used to be river sediment and were temporarily stored within the semi-underground exhibition space of Mammoth Park. As part of the pre-conservation investigations, the primary aim of the research presented was to characterize the culturable mycobiomes of two excavated wooden artifacts so that appropriate conservation procedures for alleviating post-excavation fungal infestation could be formulated. Utilizing culture-based methods, a total of 32 fungi from 15 genera were identified, mainly Ascomycota and to a lesser extent Mucoromycota sensu stricto. Soft-rot Ascomycota of genus Penicillium, followed by Aspergillus and Cephalotrichum species, were the most diverse of the isolated fungi. Out of a total of 38 isolates, screened on 7 biodegradation plate assays, 32 (84.21%) demonstrated at least one degradative property. Penicillium solitum had the highest deterioration potential, with a positive reaction in 5 separate plate assays. The obtained results further broaden the limited knowledge on the peculiarities of post-excavation soft-rot decay of archaeological wood and indicate the biochemical mechanisms at the root of post-excavation fungal deterioration. Full article
19 pages, 1321 KiB  
Article
Design and Parameter Optimization of Rotary Double-Insertion Device for Small Arched Insertion Machine
by Jianling Hu, Yan Gong and Xiao Chen
Agriculture 2024, 14(5), 739; https://doi.org/10.3390/agriculture14050739 (registering DOI) - 9 May 2024
Abstract
China’s small arched shed-building machinery suffers from a low degree of mechanization, building efficiency, and qualification rate for frame insertion. Therefore, we designed a rotary double-insertion device and established the equation for its motion trajectory. The analysis shows that in the rotary insertion [...] Read more.
China’s small arched shed-building machinery suffers from a low degree of mechanization, building efficiency, and qualification rate for frame insertion. Therefore, we designed a rotary double-insertion device and established the equation for its motion trajectory. The analysis shows that in the rotary insertion process, a better point of entry into the soil exists. A simulation model was constructed in ADAMS, and the static and dynamic trajectories were analyzed. Additionally, the optimal planting and insertion speed ratios were determined. Considering the qualified rate of the insertion frame as the evaluation index to establish a regression model, we adopted a three-factor three-level experimental design and established the planting speed ratio, center distance of the planting arm, and length of the pressing rod arm as the main influencing factors. We used Design-Expert 13 to perform the analysis of variance and determined the optimal parameter combinations. The experimental results show that the planting speed ratio was 0.7, the center distance of the planting arm group was 554 mm, the length of the pressing rod arm was 923 mm, and the qualification rate of trellis planting at this time was 98.05%. The bench was adjusted and tested based on the optimal parameter combination. The average value of the measured trellis qualification rate was 96.73%, and the relative error between the test value and the theoretical optimization value was 1.32%, thereby verifying the reliability of the optimal parameter combination. Field verification test results show that the rotary double-insertion device had a planting speed ratio of 0.7 and a trellis qualified rate of 95.74% compared with the theoretical optimization value of 2.31%. Conforming to the design requirements of small arch shed-building machinery, the prototype operation performance was stable. Full article
(This article belongs to the Section Agricultural Technology)
14 pages, 960 KiB  
Review
The Role of Wheatgrass in Colorectal Cancer: A Review of the Current Evidence
by Magie Tamraz, Najib Al Ghossaini and Sally Temraz
Int. J. Mol. Sci. 2024, 25(10), 5166; https://doi.org/10.3390/ijms25105166 (registering DOI) - 9 May 2024
Abstract
The etiology of colon cancer is either genetic in nature or results from inflammatory bowel diseases such as ulcerative colitis and Crohn’s disease; nevertheless, dietary habits play a crucial role in the disease. Wheatgrass is a dietary supplement that is rich in vitamins, [...] Read more.
The etiology of colon cancer is either genetic in nature or results from inflammatory bowel diseases such as ulcerative colitis and Crohn’s disease; nevertheless, dietary habits play a crucial role in the disease. Wheatgrass is a dietary supplement that is rich in vitamins, minerals, and antioxidants which contribute to health promotion in cardiovascular diseases, liver disease, blood diseases, diabetes, and inflammatory bowel diseases, as well as in several types of cancers, such as oral squamous cell cancer, cervical cancer, and breast cancer. In colorectal cancer (CRC), the prospect that wheatgrass possesses anti-inflammatory, antioxidant, and anticancer properties, and its use as an adjunctive therapy, have been minimally investigated and evidence is still limited. In this review, we compiled the available evidence pertaining to wheatgrass and its likely impact on CRC, described the pathways of inflammation in which wheatgrass could possibly play a role, and identified future research needs on the subject. Full article
(This article belongs to the Special Issue Novel Molecular Pathways in Oncology 2.0)
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14 pages, 4451 KiB  
Article
Discrete-Time Adaptive Control for Three-Phase PWM Rectifier
by Bo Hou, Jiayan Qi and Huan Li
Sensors 2024, 24(10), 3010; https://doi.org/10.3390/s24103010 (registering DOI) - 9 May 2024
Abstract
This paper proposes a dual-loop discrete-time adaptive control (DDAC) method for three-phase PWM rectifiers, which considers inductance-parameter-mismatched and DC load disturbances. A discrete-time model of the three-phase PWM rectifier is established using the forward Euler discretization method, and a dual-loop discrete-time feedback linearization [...] Read more.
This paper proposes a dual-loop discrete-time adaptive control (DDAC) method for three-phase PWM rectifiers, which considers inductance-parameter-mismatched and DC load disturbances. A discrete-time model of the three-phase PWM rectifier is established using the forward Euler discretization method, and a dual-loop discrete-time feedback linearization control (DDFLC) is given. Based on the DDFLC, the DDAC is designed. Firstly, an adaptive inductance disturbance observer (AIDO) based on the gradient descent method is proposed in the current control loop. The AIDO is used to estimate lump disturbances caused by mismatched inductance parameters and then compensate for these disturbances in the current controller, ensuring its strong robustness to inductance parameters. Secondly, a load parameter adaptive law (LPAL) based on the discrete-time Lyapunov theory is proposed for the voltage control loop. The LPAL estimates the DC load parameter in real time and subsequently adjusts it in the voltage controller, achieving DC load adaptability. Finally, simulation and experimental results show that the DDAC exhibits better steady and dynamic performances, less current harmonic content than the DDFLC and the dual-loop discrete-time PI control (DDPIC), and a stronger robustness to inductance parameters and DC load disturbances. Full article
(This article belongs to the Section Physical Sensors)
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24 pages, 8780 KiB  
Article
Digitization of AEC Industries Based on BIM and 4.0 Technologies
by Karol Zawada, Kinga Rybak-Niedziółka, Mikołaj Donderewicz and Agnieszka Starzyk
Buildings 2024, 14(5), 1350; https://doi.org/10.3390/buildings14051350 (registering DOI) - 9 May 2024
Abstract
BIM and 4.0 technologies are currently the leading branches of digitization in construction. The aim of this article is to confront theses on building information modeling (BIM) and coexisting technologies, and to present an analysis along with conclusions regarding the digitization process of [...] Read more.
BIM and 4.0 technologies are currently the leading branches of digitization in construction. The aim of this article is to confront theses on building information modeling (BIM) and coexisting technologies, and to present an analysis along with conclusions regarding the digitization process of AEC industries using BIM methodology and advanced digital technologies within the scope of 4.0 technologies. Key aspects of BIM and 4.0 technology integration were discussed, including artificial intelligence (AI) or big data and data science analytics. The impact of these fields on design processes, as well as on data management, monitoring of design and construction progress, and overall efficiency of AEC industries, was analyzed. The article pays particular attention to the synergy between BIM and 4.0 technology, identifying benefits, challenges, and development perspectives. Conclusions indicate the growing importance of interdisciplinarity for improving AEC industry processes and the need to adapt to the changing digital landscape in the field of design and construction. A survey was conducted, where respondents’ answers were presented in the form of charts. Questions focused on the issue of the use of BIM methodology along with coexisting technologies in the design process by the Polish engineering staff. The research results indicate that the use of the latest technological solutions in Poland is still rare, and the digital potential of these solutions is not fully utilized. The article can make a significant contribution to the discussion on technological evolution in AEC industries, identifying development directions in the context of digitization and the use of the latest achievements of 4.0 technology. Previous research has not included such a wide spectrum of BIM use in Poland. An analysis was conducted comparing Poland in a global context with other countries in BIM adoption. Full article
(This article belongs to the Special Issue BIM-Based Construction Management: Trends and Prospects)
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22 pages, 6258 KiB  
Review
Contact Dermatitis Due to Hair Care Products: A Comprehensive Review
by Marta Cebolla-Verdugo, Juan Pablo Velasco-Amador and Francisco José Navarro-Triviño
Cosmetics 2024, 11(3), 78; https://doi.org/10.3390/cosmetics11030078 (registering DOI) - 9 May 2024
Abstract
Hair cosmetics are in fashion. Numerous products are commonly used in combination. Frequent allergens are present in hair cosmetics, which, with almost daily use, increase the risk of sensitization. Familiarity with the clinical distribution of the eczematous rash is necessary to seriously consider [...] Read more.
Hair cosmetics are in fashion. Numerous products are commonly used in combination. Frequent allergens are present in hair cosmetics, which, with almost daily use, increase the risk of sensitization. Familiarity with the clinical distribution of the eczematous rash is necessary to seriously consider patch testing. Not all the products on the market are haptens. It is necessary to know how to patch your own products. When avoidance of the allergen is not possible, new treatments are evaluated to combat allergic contact dermatitis, mainly of the occupational type. In this manuscript, a complete and practical review of the main allergens and contact sources of hair cosmetic origin has been carried out. Full article
17 pages, 2537 KiB  
Article
Joint Phase Shift Design and Resource Management for a Non-Orthogonal Multiple Access-Enhanced Internet of Vehicle Assisted by an Intelligent Reflecting Surface-Equipped Unmanned Aerial Vehicle
by Lijuan Wang, Yixin He, Bin Chen, Abual Hassan, Dawei Wang, Lina Yang and Fanghui Huang
Drones 2024, 8(5), 188; https://doi.org/10.3390/drones8050188 (registering DOI) - 9 May 2024
Abstract
This paper integrates intelligent reflecting surfaces (IRS) with unmanned aerial vehicles (UAV) to enhance the transmission performance of the Internet of Vehicles (IoV) through non-orthogonal multiple access (NOMA). It focuses on strengthening the signals from cell edge vehicles (CEVs) to the base station [...] Read more.
This paper integrates intelligent reflecting surfaces (IRS) with unmanned aerial vehicles (UAV) to enhance the transmission performance of the Internet of Vehicles (IoV) through non-orthogonal multiple access (NOMA). It focuses on strengthening the signals from cell edge vehicles (CEVs) to the base station by optimizing the wireless propagation environment via an IRS-equipped UAV. The primary goal is to maximize the sum data rate of CEVs while satisfying the constraint of the successive interference cancellation (SIC) decoding threshold. The challenge lies in the non-convex nature of jointly considering the power control, subcarrier allocation, and phase shift design, making the problem difficult to optimally solve. To address this, the problem is decomposed into two independent subproblems, which are then solved iteratively. Specifically, the optimal phase shift design is achieved using the deep deterministic policy gradient (DDPG) algorithm. Furthermore, the graph theory is applied to determine the subcarrier allocation policy and derive a closed-form solution for optimal power control. Finally, the simulation results show that the proposed joint phase shift and resource management scheme significantly enhances the sum data rate compared to the state-of-the-art schemes, thereby demonstrating the benefits of integrating the IRS-equipped UAV into NOMA-enhanced IoV. Full article
(This article belongs to the Section Drone Communications)
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20 pages, 3077 KiB  
Article
Spectral Superresolution Using Transformer with Convolutional Spectral Self-Attention
by Xiaomei Liao, Lirong He, Jiayou Mao and Meng Xu
Remote Sens. 2024, 16(10), 1688; https://doi.org/10.3390/rs16101688 (registering DOI) - 9 May 2024
Abstract
Hyperspectral images (HSI) find extensive application across numerous domains of study. Spectral superresolution (SSR) refers to reconstructing HSIs from readily available RGB images using the mapping relationships between RGB images and HSIs. In recent years, convolutional neural networks (CNNs) have become widely adopted [...] Read more.
Hyperspectral images (HSI) find extensive application across numerous domains of study. Spectral superresolution (SSR) refers to reconstructing HSIs from readily available RGB images using the mapping relationships between RGB images and HSIs. In recent years, convolutional neural networks (CNNs) have become widely adopted in SSR research, primarily because of their exceptional ability to extract features. However, most current CNN-based algorithms are weak in terms of extracting the spectral features of HSIs. While certain algorithms can reconstruct HSIs through the fusion of spectral and spatial data, their practical effectiveness is hindered by their substantial computational complexity. In light of these challenges, we propose a lightweight network, Transformer with convolutional spectral self-attention (TCSSA), for SSR. TCSSA comprises a CNN-Transformer encoder and a CNN-Transformer decoder, in which the convolutional spectral self-attention blocks (CSSABs) are the basic modules. Multiple cascaded encoding and decoding modules within TCSSA facilitate the efficient extraction of spatial and spectral contextual information from HSIs. The convolutional spectral self-attention (CSSA) as the basic unit of CSSAB combines CNN with self-attention in the transformer, effectively extracting both spatial local features and global spectral features from HSIs. Experimental validation of TCSSA’s effectiveness is performed on three distinct datasets: GF5 for remote sensing images along with CAVE and NTIRE2022 for natural images. The experimental results demonstrate that the proposed method achieves a harmonious balance between reconstruction performance and computational complexity. Full article
22 pages, 9676 KiB  
Article
Modeling- and Simulation-Driven Methodology for the Deployment of an Inland Water Monitoring System
by Giordy A. Andrade, Segundo Esteban, José L. Risco-Martín, Jesús Chacón and Eva Besada-Portas
Information 2024, 15(5), 267; https://doi.org/10.3390/info15050267 (registering DOI) - 9 May 2024
Abstract
In response to the challenges introduced by global warming and increased eutrophication, this paper presents an innovative modeling and simulation (M&S)-driven model for developing an automated inland water monitoring system. This system is grounded in a layered Internet of Things (IoT) architecture and [...] Read more.
In response to the challenges introduced by global warming and increased eutrophication, this paper presents an innovative modeling and simulation (M&S)-driven model for developing an automated inland water monitoring system. This system is grounded in a layered Internet of Things (IoT) architecture and seamlessly integrates cloud, fog, and edge computing to enable sophisticated, real-time environmental surveillance and prediction of harmful algal and cyanobacterial blooms (HACBs). Utilizing autonomous boats as mobile data collection units within the edge layer, the system efficiently tracks algae and cyanobacteria proliferation and relays critical data upward through the architecture. These data feed into advanced inference models within the cloud layer, which inform predictive algorithms in the fog layer, orchestrating subsequent data-gathering missions. This paper also details a complete development environment that facilitates the system lifecycle from concept to deployment. The modular design is powered by Discrete Event System Specification (DEVS) and offers unparalleled adaptability, allowing developers to simulate, validate, and deploy modules incrementally and cutting across traditional developmental phases. Full article
(This article belongs to the Special Issue Internet of Things and Cloud-Fog-Edge Computing)
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11 pages, 2236 KiB  
Article
Na and K Intake from Lunches Served in a Japanese Company Cafeteria and the Estimated Improvement in the Dietary Na/K Ratio Using Low-Na/K Seasonings and Dairy to Prevent Hypertension
by Nagako Okuda, Aya Higashiyama, Kozo Tanno, Yuki Yonekura, Makoto Miura, Hiroshi Kuno, Toru Nakajima, Tomomi Nagahata, Hirokazu Taniguchi, Koki Kosami, Kyoko Kojima and Akira Okayama
Nutrients 2024, 16(10), 1433; https://doi.org/10.3390/nu16101433 (registering DOI) - 9 May 2024
Abstract
The excessive intake of sodium (Na) and insufficient intake of potassium (K) are major concerns in the prevention of hypertension. Using low-Na/K seasonings (reducing 25% of the NaCl and adding K salt) may improve the dietary Na/K ratio and help prevent hypertension. To [...] Read more.
The excessive intake of sodium (Na) and insufficient intake of potassium (K) are major concerns in the prevention of hypertension. Using low-Na/K seasonings (reducing 25% of the NaCl and adding K salt) may improve the dietary Na/K ratio and help prevent hypertension. To devise an intervention study using low-Na/K seasonings at a company cafeteria, we calculated the Na and K contents of the meals served at the cafeteria and estimated changes in the intakes when suitable low-Na/K seasonings were used. We also considered using milk as a good source of K. We used an ingredient list of a company cafeteria and calculated Na and K contents in each dish. The average amounts of NaCl and K per use were 5.04 g and 718 mg, respectively. Seasonings contributed 70.9% of the NaCl. With the use of low-Na/K seasonings, an estimated reduction in NaCl of 0.8 g/day and an estimated increase in K of 308 mg/day was achieved. With an additional serving (200 mL) of milk, NaCl was reduced by 0.57 g/day and K was increased by 610 mg/day, with an overall decrease in the dietary Na/K ratio from 3.20 to 2.40. The use of low-Na/K seasonings and dairy may improve the dietary Na/K ratio among cafeteria users and help prevent hypertension. Full article
(This article belongs to the Section Nutrition and Public Health)
17 pages, 543 KiB  
Article
Exploring the Relationship between Built Environment Attributes and Physical Activity in Lower-Income Aging Adults: Preliminary Insights from a Multi-Level Trial
by Arjan S. Walia, Abby C. King, Maria I. Campero, Dulce M. Garcia, Rebecca E. Lee and Astrid N. Zamora
Int. J. Environ. Res. Public Health 2024, 21(5), 607; https://doi.org/10.3390/ijerph21050607 (registering DOI) - 9 May 2024
Abstract
The built environment has been linked to physical activity (PA) behaviors, yet there is limited knowledge of this association among lower-income midlife and older adults who are insufficiently active. The present cross-sectional study utilized baseline data collected between October 2017 and November 2019 [...] Read more.
The built environment has been linked to physical activity (PA) behaviors, yet there is limited knowledge of this association among lower-income midlife and older adults who are insufficiently active. The present cross-sectional study utilized baseline data collected between October 2017 and November 2019 from a clustered randomized controlled trial to determine how built environment attributes were associated with PA behaviors among midlife and older adults (n = 255) residing in or near affordable housing sites (n = 10). At each site, perceptions of the built environment were collected and scored at the participant level via the abbreviated Neighborhood Environment Walkability Survey (NEWS-A), while objective built environment attributes were measured and scored by trained research staff using the Physical Activity Resource Assessment (PARA). Multiple PA behaviors—walking, total PA, and moderate-to-vigorous PA (MVPA) (min/wk)—were measured using the validated Community Healthy Activities Model Program for Seniors (CHAMPS) questionnaire. Adjusted linear regression models examined associations between NEWS-A measures and PA behaviors, and site-level correlations between PARA measures and PA behaviors were examined using Spearman’s rank correlations. At the participant level, adjusted models revealed that a one point increase in the NEWS-A aesthetics score was associated with a 57.37 min/wk increase in walking (β = 57.37 [95% CI: 20.84, 93.91], p = 0.002), with a similar association observed for street connectivity and MVPA (β = 24.31 min/wk [95% CI: 3.22, 45.41], p = 0.02). At the site level, MVPA was positively correlated with the quality of the features of local, PA-supportive environmental resources (ρ = 0.82, p = 0.004). Findings indicate that participant- and site-level measures of the built environment may play a role in promoting PA behavior among this demographic and similar populations. Results also suggest that improvements in aesthetic attributes and street connectivity, along with enhancing the quality of local, PA-supportive environmental resources, may be effective strategies for promoting physical activity among lower-income midlife and older adults. Full article
(This article belongs to the Section Environmental Health)
14 pages, 1142 KiB  
Review
New Insight into Utilization of Fish By-Product Proteins and Their Skin Health Promoting Effects
by Dongcheng Liu, Yongxin Ren, Saiyi Zhong and Baojun Xu
Mar. Drugs 2024, 22(5), 215; https://doi.org/10.3390/md22050215 (registering DOI) - 9 May 2024
Abstract
In regions reliant on fisheries for livelihoods, a significant number of fish by-products are generated annually due to processing. These discarded parts contain valuable biological resources, such as proteins, fish oils, and trace elements, thus holding enormous potential for reutilization. In recent years, [...] Read more.
In regions reliant on fisheries for livelihoods, a significant number of fish by-products are generated annually due to processing. These discarded parts contain valuable biological resources, such as proteins, fish oils, and trace elements, thus holding enormous potential for reutilization. In recent years, fish by-product proteins have been widely utilized in skincare products due to their rich collagen content, biosafety, and biocompatibility. This review summarizes the research into and applications of fish by-product proteins in skin health, including alleviating oxidative stress and skin inflammation, reducing DNA damage, mitigating melanin production, improving skin hydration, slowing skin matrix degradation, and promoting synthesis. Additionally, the possibility of improving skin health by improving the abundance of gut microbiota is also discussed. This review underscores the importance of fish by-product proteins in the fisheries, food processing, cosmetics, and biomedical industries. Full article
12 pages, 564 KiB  
Article
Dynamics Behavior of a Predatorg-Prey Diffusion Model Incorporating Hunting Cooperation and Predator-Taxis
by Huisen Zhang
Mathematics 2024, 12(10), 1474; https://doi.org/10.3390/math12101474 (registering DOI) - 9 May 2024
Abstract
In this paper, we consider a predator-prey diffusion model incorporating hunting cooperation and predator-taxis. Firstly, we establish the global existence of a classical solution for the model in any spatial dimension. Secondly, we analyze the stability/instability caused by predator-taxis, and we observe that [...] Read more.
In this paper, we consider a predator-prey diffusion model incorporating hunting cooperation and predator-taxis. Firstly, we establish the global existence of a classical solution for the model in any spatial dimension. Secondly, we analyze the stability/instability caused by predator-taxis, and we observe that predator-taxis play a key role in inducing stability changes. Specifically, if the positive equilibrium is stable for the corresponding reaction-diffusion model, the attractive predator-taxis can further stabilize the system, while the repulsive predator-taxis may lead to a change in spatial stability, if the positive equilibrium is unstable for the corresponding reaction-diffusion model, the attractive predator-taxis makes the model remain unstable, while the repulsive predator-taxis has a stabilizing effect. Finally, numerical simulations are employed to validate the obtained results. Full article
27 pages, 2982 KiB  
Review
Advancements in Biochar Modification for Enhanced Phosphorus Utilization in Agriculture
by Nazir Ahmed, Lifang Deng, Chuan Wang, Zia-ul-Hassan Shah, Lansheng Deng, Yongquan Li, Juan Li, Sadaruddin Chachar, Zaid Chachar, Faisal Hayat, Bilquees Bozdar, Filza Ansari, Rashid Ali, Lin Gong and Panfeng Tu
Land 2024, 13(5), 644; https://doi.org/10.3390/land13050644 (registering DOI) - 9 May 2024
Abstract
The role of modified biochar in enhancing phosphorus (P) availability is gaining attention as an environmentally friendly approach to address soil P deficiency, a global agricultural challenge. Traditional phosphatic fertilizers, while essential for crop yield, are costly and environmentally detrimental owing to P [...] Read more.
The role of modified biochar in enhancing phosphorus (P) availability is gaining attention as an environmentally friendly approach to address soil P deficiency, a global agricultural challenge. Traditional phosphatic fertilizers, while essential for crop yield, are costly and environmentally detrimental owing to P fixation and leaching. Modified biochar presents a promising alternative with improved properties such as increased porosity, surface area, and cation exchange capacity. This review delves into the variability of biochar properties based on source and production methods and how these can be optimized for effective P adsorption. By adjusting properties such as pH levels and functional groups to align with the phosphate’s zero point of charge, we enhance biochar’s ability to adsorb and retain P, thereby increasing its bioavailability to plants. The integration of nanotechnology and advanced characterization techniques aids in understanding the structural nuances of biochar and its interactions with phosphorus. This approach offers multiple benefits: it enables farmers to use phosphorus more efficiently, reducing the need for traditional fertilizers and thereby minimizing environmental impacts, such as greenhouse gas emissions and P leaching. This review also identifies existing research gaps and future opportunities for further biochar modifications. These findings emphasize the significant potential of modified biochar in sustainable agriculture. Full article
(This article belongs to the Special Issue Plant-Soil Interactions in Agricultural Systems)
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20 pages, 987 KiB  
Review
Is Collaborative Care the Future of Medicine? Lessons Learned from the Care of Children with Colorectal Conditions
by Julie M. Choueiki, Stephen Sales, Susan Callicott, David Ashman, Katherine Worst, Andrea Badillo, Briony K. Varda, Allison Mayhew, Thomas O. Xu and Marc A. Levitt
Children 2024, 11(5), 570; https://doi.org/10.3390/children11050570 (registering DOI) - 9 May 2024
Abstract
The treatment of patients with colorectal disorders requires care from a wide variety of medical and surgical specialties over the course of their lifetime. This is ideally handled by a collaborative center which facilitates the assessment and development of patient care among multiple [...] Read more.
The treatment of patients with colorectal disorders requires care from a wide variety of medical and surgical specialties over the course of their lifetime. This is ideally handled by a collaborative center which facilitates the assessment and development of patient care among multiple specialties which can enhance the quality and implementation of treatment plans, improve communication among different specialties, decrease morbidity, and improve patient satisfaction and outcomes. This collaborative approach can serve as a model for other parts of medicine requiring a similar multi-disciplinary and integrated method of care delivery. We describe the process, as well as the lessons learned in developing such a program. Full article
(This article belongs to the Special Issue Recent Advances in Pediatric Colorectal Surgery)
18 pages, 1840 KiB  
Article
Correlations of the CNR1 Gene with Personality Traits in Women with Alcohol Use Disorder
by Filip Maciocha, Aleksandra Suchanecka, Krzysztof Chmielowiec, Jolanta Chmielowiec, Andrzej Ciechanowicz and Agnieszka Boroń
Int. J. Mol. Sci. 2024, 25(10), 5174; https://doi.org/10.3390/ijms25105174 (registering DOI) - 9 May 2024
Abstract
Alcohol use disorder (AUD) is a significant issue affecting women, with severe consequences for society, the economy, and most importantly, health. Both personality and alcohol use disorders are phenotypically very complex, and elucidating their shared heritability is a challenge for medical genetics. Therefore, [...] Read more.
Alcohol use disorder (AUD) is a significant issue affecting women, with severe consequences for society, the economy, and most importantly, health. Both personality and alcohol use disorders are phenotypically very complex, and elucidating their shared heritability is a challenge for medical genetics. Therefore, our study investigated the correlations between the microsatellite polymorphism (AAT)n of the Cannabinoid Receptor 1 (CNR1) gene and personality traits in women with AUD. The study group included 187 female subjects. Of these, 93 were diagnosed with alcohol use disorder, and 94 were controls. Repeat length polymorphism of microsatellite regions (AAT)n in the CNR1 gene was identified with PCR. All participants were assessed with the Mini-International Neuropsychiatric Interview and completed the NEO Five-Factor and State-Trait Anxiety Inventories. In the group of AUD subjects, significantly fewer (AAT)n repeats were present when compared with controls (p = 0.0380). While comparing the alcohol use disorder subjects (AUD) and the controls, we observed significantly higher scores on the STAI trait (p < 0.00001) and state scales (p = 0.0001) and on the NEO Five-Factor Inventory Neuroticism (p < 0.00001) and Openness (p = 0.0237; insignificant after Bonferroni correction) scales. Significantly lower results were obtained on the NEO-FFI Extraversion (p = 0.00003), Agreeability (p < 0.00001) and Conscientiousness (p < 0.00001) scales by the AUD subjects when compared to controls. There was no statistically significant Pearson’s linear correlation between the number of (AAT)n repeats in the CNR1 gene and the STAI and NEO Five-Factor Inventory scores in the group of AUD subjects. In contrast, Pearson’s linear correlation analysis in controls showed a positive correlation between the number of the (AAT)n repeats and the STAI state scale (r = 0.184; p = 0.011; insignificant after Bonferroni correction) and a negative correlation with the NEO-FFI Openness scale (r = −0.241; p = 0.001). Interestingly, our study provided data on two separate complex issues, i.e., (1) the association of (AAT)n CNR1 repeats with the AUD in females; (2) the correlation of (AAT)n CNR1 repeats with anxiety as a state and Openness in non-alcohol dependent subjects. In conclusion, our study provided a plethora of valuable data for improving our understanding of alcohol use disorder and anxiety. Full article
(This article belongs to the Section Molecular Biology)
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20 pages, 4578 KiB  
Article
Distinctiveness of Femoral and Acetabular Mesenchymal Stem and Progenitor Populations in Patients with Primary and Secondary Hip Osteoarthritis Due to Developmental Dysplasia
by Mihovil Plečko, Nataša Kovačić, Danka Grčević, Alan Šućur, Andreja Vukasović Barišić, Tea Duvančić, Ivan Bohaček and Domagoj Delimar
Int. J. Mol. Sci. 2024, 25(10), 5173; https://doi.org/10.3390/ijms25105173 (registering DOI) - 9 May 2024
Abstract
Primary hip osteoarthritis (pOA) develops without an apparent underlying reason, whereas secondary osteoarthritis arises due to a known cause, such as developmental dysplasia of the hips (DDH-OA). DDH-OA patients undergo total hip arthroplasty at a much younger age than pOA patients (50.58 vs. [...] Read more.
Primary hip osteoarthritis (pOA) develops without an apparent underlying reason, whereas secondary osteoarthritis arises due to a known cause, such as developmental dysplasia of the hips (DDH-OA). DDH-OA patients undergo total hip arthroplasty at a much younger age than pOA patients (50.58 vs. 65 years in this study). Recently, mesenchymal stem and progenitor cells (MSPCs) have been investigated for the treatment of osteoarthritis due to their immunomodulatory and regenerative potential. This study identified cells in subchondral bone expressing common MSPC markers (CD10, CD73, CD140b, CD146, CD164, CD271, GD2, PDPN) in vivo and compared the proportions of these populations in pOA vs. DDH-OA, further correlating them with clinical, demographic, and morphological characteristics. The differences in subchondral morphology and proportions of non-hematopoietic cells expressing MSPC markers were noted depending on OA type and skeletal location. Bone sclerosis was more prominent in the pOA acetabulum (Ac) in comparison to the DDH-OA Ac and in the pOA Ac compared to the pOA femoral head (Fh). Immunophenotyping indicated diagnosis-specific differences, such as a higher proportion of CD164+ cells and their subsets in DDH-OA, while pOA contained a significantly higher proportion of CD10+ and GD2+ cells and subsets, with CD271+ being marginally higher. Location-specific differences showed that CD271+ cells were more abundant in the Fh compared to the Ac in DDH-OA patients. Furthermore, immunohistochemical characterization of stromal bone-adjacent cells expressing MSPC markers (CD10, CD164, CD271, GD2) in the Ac and Fh compartments was performed. This research proved that immunophenotype profiles and morphological changes are both location- and disease-specific. Furthermore, it provided potentially effective targets for therapeutic strategies. Future research should analyze the differentiation potential of subsets identified in this study. After proper characterization, they can be selectively targeted, thus enhancing personalized medicine approaches in joint disease management. Full article
(This article belongs to the Special Issue Osteoarthritis: From Molecular Mechanism to Novel Therapy)
13 pages, 564 KiB  
Article
Asymmetric Exchange Rate Effects on Trade Flows in India
by Niloufer Sohrabji
Economies 2024, 12(5), 114; https://doi.org/10.3390/economies12050114 (registering DOI) - 9 May 2024
Abstract
This paper examines the role of exchange rate changes on India’s trade. The drivers of exports and imports (income, exchange rate including sectoral differences, and exchange rate variability) are estimated for the short and long run including a structural break. Using annual data [...] Read more.
This paper examines the role of exchange rate changes on India’s trade. The drivers of exports and imports (income, exchange rate including sectoral differences, and exchange rate variability) are estimated for the short and long run including a structural break. Using annual data from 1994 to 2022, the results of dynamic fixed effects estimation show that both exports and imports are income-elastic in the short and long run, but income elasticity is far stronger for exports. Moreover, exports are responsive to the real effective exchange rate in the short run but not in the long run, and the reverse is true for imports. Furthermore, exchange rates have asymmetric effects for high-volume and primary sectors for exports and imports. The combined impacts show the ineffectiveness of using currency depreciation to address trade imbalances. Full article
(This article belongs to the Special Issue Exchange Rates: Drivers, Dynamics, Impacts, and Policies)
12 pages, 270 KiB  
Article
Kernel-Based Multivariate Nonparametric CUSUM Multi-Chart for Detection of Abrupt Changes
by Lei Qiao and Bing Wang
Mathematics 2024, 12(10), 1473; https://doi.org/10.3390/math12101473 (registering DOI) - 9 May 2024
Abstract
In many cases, it is difficult to obtain precise distributional information on multivariate sequences. Therefore, there is a need to propose nonparametric methods for monitoring multivariate sequences. This article discusses the multivariate change detection problem and utilizes the kernel function as the statistic [...] Read more.
In many cases, it is difficult to obtain precise distributional information on multivariate sequences. Therefore, there is a need to propose nonparametric methods for monitoring multivariate sequences. This article discusses the multivariate change detection problem and utilizes the kernel function as the statistic to construct the nonparametric Multivariate Cumulative Sum multi-chart, under the assumption that there is prior information about the abrupt changes. Through theoretical and numerical analysis, we show that the proposed control chart is more effective compared to other existing control charts. The good monitoring effect of this method demonstrates a strong potential for application. Full article
(This article belongs to the Special Issue Advances in Statistical Process Monitoring and Wavelet Analysis)

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