The 2023 MDPI Annual Report has
been released!
 
21 pages, 1970 KiB  
Review
A Systematic Review of Semaglutide’s Influence on Cognitive Function in Preclinical Animal Models and Cell-Line Studies
by Raluca Oana Tipa, Daniela-Gabriela Balan, Mihai-Teodor Georgescu, Luciana Angela Ignat, Ileana Adela Vacaroiu, Dragos Eugen Georgescu, Laura Raducu, Doina Andrada Mihai, Liviu-Vasile Chiperi and Andra-Elena Balcangiu-Stroescu
Int. J. Mol. Sci. 2024, 25(9), 4972; https://doi.org/10.3390/ijms25094972 (registering DOI) - 02 May 2024
Abstract
Since we aim to test new options to find medication for cognitive disorders, we have begun to assess the effect of semaglutide and to conduct a review gathering studies that have attempted this purpose. This systematic review focuses on the cognitive effects of [...] Read more.
Since we aim to test new options to find medication for cognitive disorders, we have begun to assess the effect of semaglutide and to conduct a review gathering studies that have attempted this purpose. This systematic review focuses on the cognitive effects of semaglutide, a glucagon-like peptide 1 receptor agonist (GLP-1 RA), in the context of neurological and cognitive impairment. Semaglutide, a synthetic GLP-1 analog, showcased neuroprotective effects beyond metabolic regulation. It mitigated apoptosis and improved cognitive dysfunction in cerebrovascular disease, suggesting broader implications for neurological well-being. Also, studies highlighted GLP-1 RAs’ positive impact on olfactory function in obese individuals with type 2 diabetes, on neurodegenerative disorders, multiple sclerosis, and endotoxemia. In order to analyze current studies that assess the impact of semaglutide on cognitive function, a literature search was conducted up to February 2024 on two online databases, MEDLINE (via PubMed) and Web of Science Core Collection, as well as various websites. Fifteen studies on mice populations and two studies on cell lines were included, analyzed, and assessed with bias-specific tools. The neuroprotective and anti-apoptotic properties of GLP-1 and its analogs were emphasized, with animal models and cell line studies demonstrating enhanced cognitive function. While promising, limitations include fewer studies, highlighting the need for extensive research, particularly in the human population. Even though this medication seems promising, there are significant limitations, one of which is the lack of studies on human subjects. Therefore, this review aims to gather current evidence. Full article
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
17 pages, 416 KiB  
Article
Evaluating Ghana’s Youth-Centered Food-Security Policies: A Collaborative Governance Approach
by Evans Sakyi Boadu
Sustainability 2024, 16(9), 3830; https://doi.org/10.3390/su16093830 (registering DOI) - 02 May 2024
Abstract
Food-security issues remain essential for decision-makers at all levels in sub-Saharan Africa (SSA), and youth-oriented food-security policies in Ghana are no exception. While there are no “one-size-fits-all” policy pathways to eradicate poverty and hunger, various governments, civil society, youth groups, and citizens can [...] Read more.
Food-security issues remain essential for decision-makers at all levels in sub-Saharan Africa (SSA), and youth-oriented food-security policies in Ghana are no exception. While there are no “one-size-fits-all” policy pathways to eradicate poverty and hunger, various governments, civil society, youth groups, and citizens can afford to ignore the present food policies’ status quo. This paper examines the perspective of sustainability when collaborative and open governance approaches are adopted by central governments and their sub-national departments, institutions, and agencies in youth-oriented food-security policymaking, implementation, and evaluation. The extent to which active stakeholder participation and collaboration, or the lack thereof, has either negatively or positively impacted food-security policies is another tangent this paper explores, including the sustainability of the youth-centered food-security policies in Ghana. Using qualitative documentary analysis technique through collaborative and open governance frameworks and drawing on the literature on multisectoral governance and youth-focused food-security policies, this paper identifies several disjointed youth-focused food-security intervention policies in Ghana with hazy institutional arrangements that have failed to ensure adequate implementation and assessment to promote cooperation, accountability, and transparency. The paper suggests the need for collaborative governance, effective policy monitoring, and evaluation strategies that involve government institutions, departments, agencies, civic societies, youth organizations, and citizens’ commitments to food security. This research finds that collaborative strategies and active youth participation in all food-security-related policies are essential for Ghana to achieve Sustainable Development Goals (SDGs) 1 and 2. Full article
29 pages, 1630 KiB  
Article
Forecasting Oil Prices with Non-Linear Dynamic Regression Modeling
by Pedro Moreno, Isabel Figuerola-Ferretti and Antonio Muñoz
Energies 2024, 17(9), 2182; https://doi.org/10.3390/en17092182 (registering DOI) - 02 May 2024
Abstract
The recent energy crisis has renewed interest in forecasting crude oil prices. This paper focuses on identifying the main drivers determining the evolution of crude oil prices and proposes a statistical learning forecasting algorithm based on regression analysis that can be used to [...] Read more.
The recent energy crisis has renewed interest in forecasting crude oil prices. This paper focuses on identifying the main drivers determining the evolution of crude oil prices and proposes a statistical learning forecasting algorithm based on regression analysis that can be used to generate future oil price scenarios. A combination of a generalized additive model with a linear transfer function with ARIMA noise is used to capture the existence of combinations of non-linear and linear relationships between selected input variables and the crude oil price. The results demonstrate that the physical market balance or fundamental is the most important metric in explaining the evolution of oil prices. The effect of the trading activity and volatility variables are significant under abnormal market conditions. We show that forecast accuracy under the proposed model supersedes benchmark specifications, including the futures prices and analysts’ forecasts. Four oil price scenarios are considered for expository purposes. Full article
(This article belongs to the Topic Energy Market and Energy Finance)
11 pages, 2554 KiB  
Article
Enhancement of perovskite photodetector using MAPbI3 with formamidinium bromide
by DongJae Shin and HyungWook Choi
Energies 2024, 17(9), 2183; https://doi.org/10.3390/en17092183 (registering DOI) - 02 May 2024
Abstract
In this study, a perovskite-based mixed cation/anion ultraviolet photodetector with an added halide material is fabricated using perovskite combined with an ABX_3 structure. Mixed cation/anion perovskite thin films of MAPbI3/FABr are manufactured through a relatively simple solution process and employed as [...] Read more.
In this study, a perovskite-based mixed cation/anion ultraviolet photodetector with an added halide material is fabricated using perovskite combined with an ABX_3 structure. Mixed cation/anion perovskite thin films of MAPbI3/FABr are manufactured through a relatively simple solution process and employed as light-absorption layers. In the produced thin film, SnO2–sodium dodecylbenzenesulfonate acts as an electron transport layer and spiro-OMeTAD acts as a hole injection layer. Compared to a single cation/anion perovskite, the fabricated device exhibits phase stability and optoelectronic properties, and demonstrates a responsivity of 72.2 mA/W and a detectability of 4.67 × 1013 Jones. In addition, the films show an external quantum efficiency of 56%. This suggests that mixed cation/anion films can replace single cation/anion perovskite films. Thus, photodetectors based on lead halides that can be applied in various fields have recently been manufactured. Full article
13 pages, 2982 KiB  
Article
Oil Quality Prediction in Olive Oil by Near-Infrared Spectroscopy: Applications in Olive Breeding
by Hande Yılmaz-Düzyaman, Raúl de la Rosa, Leonardo Velasco, Nieves Núñez-Sánchez and Lorenzo León
Agriculture 2024, 14(5), 721; https://doi.org/10.3390/agriculture14050721 (registering DOI) - 02 May 2024
Abstract
The oxidative stability index (OSI) and fatty acid (FA) composition of extra virgin olive oils (EVOOs) are key parameters in the characterization of new varieties in breeding programs. Their determination through traditional methods (Rancimat and gas chromatography, respectively) is expensive and time-consuming. Therefore, [...] Read more.
The oxidative stability index (OSI) and fatty acid (FA) composition of extra virgin olive oils (EVOOs) are key parameters in the characterization of new varieties in breeding programs. Their determination through traditional methods (Rancimat and gas chromatography, respectively) is expensive and time-consuming. Therefore, there is a need to develop rapid and cost-effective analytical procedures. This study aimed to evaluate the potential use of near-infrared spectroscopy (NIRS) for analyzing OSI and FA composition in EVOOs. A total of 318 samples sourced from different origins were evaluated using both FT-NIR MPA and MicroNIR instruments in transmittance mode, with wavelengths ranging from 1100 to 2500 nm and 908 to 1676 nm, respectively. Different accuracies were obtained in the models developed for the different evaluated traits, with simpler models (using a lower number of latent variables) for the MPA analyzer in all cases. Additionally, consistent results between instruments for the partitioning of the variance and heritability estimation, and the reliable ranking of genotypes were obtained from one of the sample sets tested. In summary, models derived from PLS regression using spectroscopic data of both instruments demonstrated promising results in determining these EVOO traits, facilitating their evaluation and selection of genotypes, particularly in breeding programs. Full article
(This article belongs to the Special Issue Feature Papers in Genotype Evaluation and Breeding)
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14 pages, 1562 KiB  
Article
Detailed Insight into the Behaviour of Chlorophyll a Fluorescence Transient Curves and Parameters during Different Times of Dark Adaptation in Sunflower Leaves
by Antonela Markulj Kulundžić, Aleksandra Sudarić, Maja Matoša Kočar, Tomislav Duvnjak, Ivica Liović, Anto Mijić, Ivana Varga and Marija Viljevac Vuletić
Agronomy 2024, 14(5), 954; https://doi.org/10.3390/agronomy14050954 (registering DOI) - 02 May 2024
Abstract
The reason for this examination is today’s wide usage of chlorophyll a fluorescence (ChlF) among researchers worldwide to measure photosynthetic efficiency. Although the instructions of the ChlF measuring device clearly emphasize the need for methodology adjustments, depending on the specific plant species, many [...] Read more.
The reason for this examination is today’s wide usage of chlorophyll a fluorescence (ChlF) among researchers worldwide to measure photosynthetic efficiency. Although the instructions of the ChlF measuring device clearly emphasize the need for methodology adjustments, depending on the specific plant species, many researchers use the usual 30 min of dark adaptation before measurement. Namely, before any ChlF measurement, it is necessary to determine the specific duration of the leaf adaptation to the conditions of darkness of each plant tissue. Because of the numerous uses of the ChlF measurements, we decided to conduct this research to determine whether the appearance of the curves and parameter values depend on the time of sunflower leaf tissue adaptation to dark conditions. Therefore, this research aimed to examine the optimal adaptation time of sunflower tissue to dark conditions to obtain timely precise measurements and credible appearance of ChlF transient curves as well as accurate parameter values. The research was carried out on the sunflower hybrid Luka with 0, 15, 30, 45, 60, 75 and 90 min of dark adaptation in the vegetative, budding and flowering stages in the field conditions. According to the analyzed transient curves and parameters, it was determined that sunflower leaves should be kept in dark conditions for at least 15 min before the measurement of ChlF, which leads to the complete oxidation of PSII and the electron transport chain prior to a saturating pulse of light. Full article
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21 pages, 5915 KiB  
Article
YOLOv8-LMG: An Improved Bearing Defect Detection Algorithm Based on YOLOv8
by Minggao Liu, Ming Zhang, Xinlan Chen, Chunting Zheng and Haifeng Wang
Processes 2024, 12(5), 930; https://doi.org/10.3390/pr12050930 (registering DOI) - 02 May 2024
Abstract
In industrial manufacturing, bearings are crucial for machinery stability and safety. Undetected wear or cracks can lead to severe operational and financial setbacks. Thus, accurately identifying bearing defects is essential for maintaining production safety and equipment reliability. This research introduces an improved bearing [...] Read more.
In industrial manufacturing, bearings are crucial for machinery stability and safety. Undetected wear or cracks can lead to severe operational and financial setbacks. Thus, accurately identifying bearing defects is essential for maintaining production safety and equipment reliability. This research introduces an improved bearing defect detection model, YOLOv8-LMG, which is based on the YOLOv8n framework and incorporates four innovative technologies: the VanillaNet backbone network, the Lion optimizer, the CFP-EVC module, and the Shape-IoU loss function. These enhancements significantly increase detection efficiency and accuracy. YOLOv8-LMG achieves a [email protected] of 86.5% and a [email protected]–0.95 of 57.0% on the test dataset, surpassing the original YOLOv8n model while maintaining low computational complexity. Experimental results reveal that the YOLOv8-LMG model boosts accuracy and efficiency in bearing defect detection, showcasing its significant potential and practical value in advancing industrial inspection technologies. Full article
(This article belongs to the Special Issue Fault Diagnosis Process and Evaluation in Systems Engineering)
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22 pages, 624 KiB  
Article
Let Them Shine: Associations of Schools’ Support for Strengths Use with Teachers’ Sense of Meaning, Engagement, and Satisfaction
by Shiri Lavy, Marian Abu Ahmad and Eman Naama
Sustainability 2024, 16(9), 3832; https://doi.org/10.3390/su16093832 (registering DOI) - 02 May 2024
Abstract
The present research builds on the psychology of sustainability and sustainable development and on research demonstrating the contribution of perceived organizational support for strengths use (POSSU) to the quality of employees’ work life. Specifically, we focus on teachers, whose training and development in [...] Read more.
The present research builds on the psychology of sustainability and sustainable development and on research demonstrating the contribution of perceived organizational support for strengths use (POSSU) to the quality of employees’ work life. Specifically, we focus on teachers, whose training and development in schools often aim to narrow competence gaps and correct deficits. We propose that focusing on the development of their strengths may more positively impact their engagement, satisfaction, and sense of meaning at work. A total of 47 school principals (30 women; Mage = 48.37, SD = 7.31) and 235 of their teachers (197 women; Mage = 40.73, SD = 7.78) reported perceptions of their schools’ organizational support for strengths use (POSSU), and of their school support for deficit correction (POSDC). In addition, teachers completed measures of their strengths use, sense of meaning at work, work engagement, and job satisfaction. Teachers’ POSSU was associated (more strongly than POSDC) with teachers’ strength use and positive work-related well-being. Teachers’ strengths use mediated the associations of POSSU with the other variables. Principals’ POSSU was not associated with teachers’ POSSU or with teachers’ strengths use, but was associated with teachers’ sense of meaning and satisfaction at work. The findings highlight the potential benefits of a strengths-supporting school culture to teachers’ work-life quality. Full article
(This article belongs to the Section Psychology of Sustainability and Sustainable Development)
21 pages, 7968 KiB  
Article
Choosing the Most Suitable Working Fluid for a CTEC
by Aliet Achkienasi, Rodolfo Silva, Edgar Mendoza and Luis D. Luna
Energies 2024, 17(9), 2181; https://doi.org/10.3390/en17092181 (registering DOI) - 02 May 2024
Abstract
This study aims to explore additional fluids beneficial for coastal thermal energy converter (CTEC) operation. Ammonia’s thermodynamic properties, characterized by higher condensation temperatures and pressures, demand significantly elevated operating pressures, resulting in a substantial energy load for efficient operation. Thus, exploring alternatives such [...] Read more.
This study aims to explore additional fluids beneficial for coastal thermal energy converter (CTEC) operation. Ammonia’s thermodynamic properties, characterized by higher condensation temperatures and pressures, demand significantly elevated operating pressures, resulting in a substantial energy load for efficient operation. Thus, exploring alternatives such as R134a becomes crucial, particularly considering its potential as a better working fluid for power generation in a Rankine cycle. The research methodology involves employing computational fluid dynamics (CFD) simulations alongside experimental investigations to examine the performance of an axial turbine concept under different working fluids. The results obtained indicate that R134a is the most appropriate working fluid for an axial turbine within a CTEC, outperforming ammonia, thereby implying significantly better operational efficiency. Full article
(This article belongs to the Section A3: Wind, Wave and Tidal Energy)
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23 pages, 5508 KiB  
Review
Research Progress on Molecularly Imprinted Materials for the Screening and Identification of Organic Pollutants
by Jialing Song, Xuanhao Lin, Liang Ying Ee and Sam F. Y. Li
Chemosensors 2024, 12(5), 72; https://doi.org/10.3390/chemosensors12050072 (registering DOI) - 02 May 2024
Abstract
Organic pollutants, distinguished by their persistence and bioaccumulation in the environment, pose significant ecological and health threats that surpass those of traditional pollutants. Crucial to understanding their environmental behavior, health risks, and mitigation strategies, is the screening and identification of these pollutants. This [...] Read more.
Organic pollutants, distinguished by their persistence and bioaccumulation in the environment, pose significant ecological and health threats that surpass those of traditional pollutants. Crucial to understanding their environmental behavior, health risks, and mitigation strategies, is the screening and identification of these pollutants. This process indispensably employs functional materials, among which molecularly imprinted polymers (MIPs) prove to be particularly advantageous because of their specific recognition capabilities and extensive application range. This review presents cutting-edge techniques and strategies for the fabrication of MIPs, including surface imprinting techniques and dummy molecular strategies. It encapsulates the last five years’ advancements in MIP research within the domains of sample pretreatment, as well as optical and electrochemical sensing analysis. The objective of this discourse is to potentially foster the evolution of MIP technology and establish the groundwork for its transition from lab-scale to commercial production. Full article
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10 pages, 1551 KiB  
Article
Antibacterial Effect of Ozone on Cariogenic Bacteria and Its Potential Prejudicial Effect on Dentin Bond Strength—An In Vitro Study
by Marta Santos, Flávia Leandro, Helena Barroso, António H. S. Delgado, Luís Proença, Mário Polido and Joana Vasconcelos e Cruz
Pharmaceutics 2024, 16(5), 614; https://doi.org/10.3390/pharmaceutics16050614 (registering DOI) - 02 May 2024
Abstract
Ozone is increasingly utilized in dental caries treatment due to its antibacterial properties. In a context of limited studies and no consensus on protocols, this research aims to assess ozone’s antibacterial efficacy on cariogenic bacteria and its potential adverse impact on dentin bond [...] Read more.
Ozone is increasingly utilized in dental caries treatment due to its antibacterial properties. In a context of limited studies and no consensus on protocols, this research aims to assess ozone’s antibacterial efficacy on cariogenic bacteria and its potential adverse impact on dentin bond strength. Streptococcus mutans, Streptococcus sobrinus, Lactobacillus casei, and Actinomyces naeslundii suspensions were exposed to 40 μg/mL of ozone gas and 60 μg/mL of ozonated water (80 s) via a medical ozone generator. Negative and positive control groups (chlorhexidine 2%) were included, and UFC/mL counts were recorded. To examine microtensile bond strength (µTBS), 20 human molars were divided into four groups, and class I cavities were created. After ozone application, samples were restored using an etch-and-rinse and resin composite, then sectioned for testing. The SPSS v. 28 program was used with a significance level of 5%. The µTBS results were evaluated using one-way ANOVA, Tukey HSD, and Games-Howell. Bacterial counts reduced from 106 to 101, but dentin µTBS was significantly impacted by ozone (ANOVA, p < 0.001). Despite ozone’s attractive antibacterial activity, this study emphasizes its detrimental effect on dentin adhesion, cautioning against its use before restorative treatments. Full article
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16 pages, 4432 KiB  
Article
Intermodal Fiber Interferometer with Spectral Interrogation and Fourier Analysis of Output Signals for Sensor Application
by Aleksandr Petrov, Andrey Golovchenko, Mikhail Bisyarin, Nikolai Ushakov and Oleg Kotov
Photonics 2024, 11(5), 423; https://doi.org/10.3390/photonics11050423 (registering DOI) - 02 May 2024
Abstract
Interferometric fiber-optic sensors provide very high measurement accuracy and come with many other benefits. As such, the study of signal processing techniques for fiber-optic interferometers in order to extract information about external perturbation is an important area of research. In this work, the [...] Read more.
Interferometric fiber-optic sensors provide very high measurement accuracy and come with many other benefits. As such, the study of signal processing techniques for fiber-optic interferometers in order to extract information about external perturbation is an important area of research. In this work, the method of Fourier analysis was applied to extract information from the output signals of an intermodal fiber interferometer with spectral interrogation. It is shown that the external perturbation can be measured by obtaining the phase spectrum of the spectral transfer function of an intermodal fiber interferometer and determining the phase difference of a certain pair of mode groups. A mathematical model of this approach was developed, taking into account the parameters of the laser and the optical fiber, the number of excited mode groups, and the parameters of external perturbation. The theoretically considered method of Fourier analysis was experimentally verified, and it was proved to provide a linear response to external perturbation in a wide dynamic range. Full article
(This article belongs to the Special Issue Fiber Optic Sensors: Science and Applications)
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24 pages, 7045 KiB  
Article
Phenotyping Wheat Kernel Symmetry as a Consequence of Different Agronomic Practices
by Tatiana S. Aniskina, Kirill A. Sudarikov, Nikita A. Prisazhnoy, Ishen N. Besaliev, Alexander A. Panfilov, Nelli S. Reger, Tatyana Kormilitsyna, Antonina A. Novikova, Alexander A. Gulevich, Svyatoslav V. Lebedev, Pyotr A. Vernik and Ekaterina N. Baranova
Symmetry 2024, 16(5), 548; https://doi.org/10.3390/sym16050548 (registering DOI) - 02 May 2024
Abstract
The use of instrumental methods of analysis in the assessment of indices that record changes in symmetry in the structure of grains to evaluate the quality of durum and soft wheat grain is currently considered a search tool that will allow us to [...] Read more.
The use of instrumental methods of analysis in the assessment of indices that record changes in symmetry in the structure of grains to evaluate the quality of durum and soft wheat grain is currently considered a search tool that will allow us to obtain previously unavailable data by finding correlations associated with differences in the shape and ratio of starch granules in conditionally symmetrical and asymmetrical wheat fruits (kernels) formed in different field conditions and with different genotypes. Indicators that had previously shown their effectiveness were used to analyze the obviously complex unique material obtained as a result of growing under critically unique sowing conditions in 2022, which affected the stability of grain development and filling. For the evaluation, a typical agronomic comparative experiment was chosen, which was used to evaluate the soil tillage practices (fallow, non-moldboard loosening, and plowing) and sowing dates (early and after excessive rainfalls), which made it possible to analyze a wider range of factors influencing the studied indices. The soil tillage methods were found to affect the uniformity of kernel fullness and their symmetry, and the sowing dates did not lead to significant differences. This study presents detailed changes in the shape of the middle cut of a wheat kernel, associated with assessing the efficiency of kernel filling and the symmetrical distribution of storage substances under the influence of external and internal physical factors that affect the formation of the wheat kernel. The data obtained may be of interest to breeders and developers of predictive phenotyping programs for cereal grain and seeds of other crops, as well as plant physiologists. Full article
(This article belongs to the Special Issue Symmetry/Asymmetry in Life Sciences: Feature Papers 2024)
16 pages, 1031 KiB  
Review
Applications of Photovoice-Based Entrepreneurial-Minded Pedagogical Interventions in the Engineering Classroom
by Bhavana Kotla and Lisa Bosman
Trends High. Educ. 2024, 3(2), 308-323; https://doi.org/10.3390/higheredu3020019 (registering DOI) - 02 May 2024
Abstract
The recent emergence of generative AI technologies is beginning to shape workforce hiring practices. The shift towards skills-based hiring over degree-based hiring has sparked concerns over the ability of college graduates to be prepared for their career roles. One approach to equip students [...] Read more.
The recent emergence of generative AI technologies is beginning to shape workforce hiring practices. The shift towards skills-based hiring over degree-based hiring has sparked concerns over the ability of college graduates to be prepared for their career roles. One approach to equip students to work with technology and adapt to rapidly changing environments is the development of an entrepreneurial mindset. One way to cultivate entrepreneurial thinking is through the participatory action research methodology, photovoice. This study explores how photovoice promotes discovery, evaluation, and exploitation of opportunities in university engineering classrooms. For this study, a literature review was conducted to identify, evaluate, and interpret available research. For the review, a five-step process was used. This process included defining a search criterion, constructing a Boolean logic search query, inserting the query into multiple academic search engines/databases, screening and selecting articles, and categorizing and mapping the literature. The review’s findings were organized based on the type of study, participants, duration of study and photovoice interventions used, study outcomes, and entrepreneurial mindset development. The results discussed in this paper offer insights, guidance, recommendations, and future directions for engineering education research. Full article
21 pages, 11491 KiB  
Article
FIWARE-Compatible Smart Data Models for Satellite Imagery and Flood Risk Assessment to Enhance Data Management
by Ioannis-Omiros Kouloglou, Gerasimos Antzoulatos, Georgios Vosinakis, Francesca Lombardo, Alberto Abella, Marios Bakratsas, Anastasia Moumtzidou, Evangelos Maltezos, Ilias Gialampoukidis, Eleftherios Ouzounoglou, Stefanos Vrochidis, Angelos Amditis, Ioannis Kompatsiaris and Michele Ferri
Information 2024, 15(5), 257; https://doi.org/10.3390/info15050257 (registering DOI) - 02 May 2024
Abstract
The increasing rate of adoption of innovative technological achievements along with the penetration of the Next Generation Internet (NGI) technologies and Artificial Intelligence (AI) in the water sector are leading to a shift to a Water-Smart Society. New challenges have emerged in terms [...] Read more.
The increasing rate of adoption of innovative technological achievements along with the penetration of the Next Generation Internet (NGI) technologies and Artificial Intelligence (AI) in the water sector are leading to a shift to a Water-Smart Society. New challenges have emerged in terms of data interoperability, sharing, and trustworthiness due to the rapidly increasing volume of heterogeneous data generated by multiple technologies. Hence, there is a need for efficient harmonization and smart modeling of the data to foster advanced AI analytical processes, which will lead to efficient water data management. The main objective of this work is to propose two Smart Data Models focusing on the modeling of the satellite imagery data and the flood risk assessment processes. The utilization of those models reinforces the fusion and homogenization of diverse information and data, facilitating the adoption of AI technologies for flood mapping and monitoring. Furthermore, a holistic framework is developed and evaluated via qualitative and quantitative performance indicators revealing the efficacy of the proposed models concerning the usage of the models in real cases. The framework is based on the well-known and compatible technologies on NGSI-LD standards which are customized and applicable easily to support the water data management processes effectively. Full article
12 pages, 885 KiB  
Article
A Multiple Scattering-Based Technique for Isotopic Identification in Cosmic Rays
by Francesco Dimiccoli and Francesco Maria Follega
Particles 2024, 7(2), 477-488; https://doi.org/10.3390/particles7020027 (registering DOI) - 02 May 2024
Abstract
Analyzing the isotopic composition of cosmic rays (CRs) provides valuable insights into the galactic environment and helps refine existing propagation models. A particular interest is devoted to secondary-to-primary ratios of light isotopic components of CRs, the measurement of which can provide complementary information [...] Read more.
Analyzing the isotopic composition of cosmic rays (CRs) provides valuable insights into the galactic environment and helps refine existing propagation models. A particular interest is devoted to secondary-to-primary ratios of light isotopic components of CRs, the measurement of which can provide complementary information with respect to secondary-to-primary ratios like B/C. Given the complexity of the concurrent measurement of velocity and momentum required to differentiate isotopes of the same Z, a task typically accomplished using magnetic spectrometers, existing measurements of these ratios only effectively characterize the low-energy region (below 1 GeV/nucl). This study introduces a novel technique for isotopic distinction in CRs at high energies up to 100 GeV/nucl based on multiple scattering, which, combined with the proposed measurement of velocity, represent an interesting alternative to magnetic spectrometers. The performance of this technique was assessed through a dedicated simulation using the GEANT4 package, with specific emphasis on Z = 1 isotopes. Full article
(This article belongs to the Special Issue Innovative Techniques for Particle Physics in Space)
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17 pages, 884 KiB  
Article
Impact of Lactic Acid Bacteria Fermentation on (Poly)Phenolic Profile and In Vitro Antioxidant and Anti-Inflammatory Properties of Herbal Infusions
by Tarik Ozturk, María Ángeles Ávila-Gálvez, Sylvie Mercier, Fernando Vallejo, Alexis Bred, Didier Fraisse, Christine Morand, Ebru Pelvan, Laurent-Emmanuel Monfoulet and Antonio González-Sarrías
Antioxidants 2024, 13(5), 562; https://doi.org/10.3390/antiox13050562 (registering DOI) - 02 May 2024
Abstract
Recently, the development of functional beverages has been enhanced to promote health and nutritional well-being. Thus, the fermentation of plant foods with lactic acid bacteria can enhance their antioxidant capacity and others like anti-inflammatory activity, which may depend on the variations in the [...] Read more.
Recently, the development of functional beverages has been enhanced to promote health and nutritional well-being. Thus, the fermentation of plant foods with lactic acid bacteria can enhance their antioxidant capacity and others like anti-inflammatory activity, which may depend on the variations in the total content and profile of (poly)phenols. The present study aimed to investigate the impact of fermentation with two strains of Lactiplantibacillus plantarum of several herbal infusions from thyme, rosemary, echinacea, and pomegranate peel on the (poly)phenolic composition and whether lacto-fermentation can contribute to enhance their in vitro antioxidant and anti-inflammatory effects on human colon myofibroblast CCD18-Co cells. HPLC-MS/MS analyses revealed that fermentation increased the content of the phenolics present in all herbal infusions. In vitro analyses indicated that pomegranate infusion showed higher antioxidant and anti-inflammatory effects, followed by thyme, echinacea, and rosemary, based on the total phenolic content. After fermentation, despite increasing the content of phenolics, the antioxidant and anti-inflammatory effects via reduction pro-inflammatory markers (IL-6, IL-8 and PGE2) were similar to those of their corresponding non-fermented infusions, with the exception of a greater reduction in lacto-fermented thyme. Overall, the findings suggest that the consumption of lacto-fermented herbal infusions could be beneficial in alleviating intestinal inflammatory disorders. Full article
(This article belongs to the Special Issue Antioxidant Activity of Fermented Foods and Food Microorganisms)
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13 pages, 1053 KiB  
Review
Exploring Salivary Epithelial Dysfunction in Sjögren’s Disease
by Braxton Noll, Micaela Beckman, Farah Bahrani Mougeot and Jean-Luc Mougeot
Int. J. Mol. Sci. 2024, 25(9), 4973; https://doi.org/10.3390/ijms25094973 (registering DOI) - 02 May 2024
Abstract
Sjögren’s Disease (SjD) is an autoimmune disease of the exocrine tissues. Etiological events result in the loss of epithelial homeostasis alongside extracellular matrix (ECM) destruction within the salivary and lacrimal glands, followed by immune cell infiltration. In this review, we have assessed the [...] Read more.
Sjögren’s Disease (SjD) is an autoimmune disease of the exocrine tissues. Etiological events result in the loss of epithelial homeostasis alongside extracellular matrix (ECM) destruction within the salivary and lacrimal glands, followed by immune cell infiltration. In this review, we have assessed the current understanding of epithelial–mesenchymal transition (EMT)-associated changes within the salivary epithelium potentially involved in salivary dysfunction and SjD pathogenesis. We performed a PubMed literature review pertaining to the determination of pathogenic events that lead to EMT-related epithelial dysfunction and signaling in SjD. Molecular patterns of epithelial dysfunction in SjD salivary glands share commonalities with EMT mediating wound healing. Pathological changes altering salivary gland integrity and function may precede direct immune involvement while perpetuating MMP9-mediated ECM destruction, inflammatory mediator expression, and eventual immune cell infiltration. Dysregulation of EMT-associated factors is present in the salivary epithelium of SjD and may be significant in initiating and perpetuating the disease. In this review, we further highlight the gap regarding mechanisms that drive epithelial dysfunction in salivary glands in the early or subclinical pre-lymphocytic infiltration stages of SjD. Full article
14 pages, 3847 KiB  
Article
Dielectric Elastomer Actuators with Enhanced Durability by Introducing a Reservoir Layer
by Sumin Jung, Minchae Kang and Min-Woo Han
Polymers 2024, 16(9), 1277; https://doi.org/10.3390/polym16091277 (registering DOI) - 02 May 2024
Abstract
A Dielectric Elastomer Actuator (DEA) consists of electrodes with a dielectric layer between them. By controlling the design of the electrodes, voltage, and frequency, the operating range and speed of the DEA can be adjusted. These DEAs find applications in biomimetic robots, artificial [...] Read more.
A Dielectric Elastomer Actuator (DEA) consists of electrodes with a dielectric layer between them. By controlling the design of the electrodes, voltage, and frequency, the operating range and speed of the DEA can be adjusted. These DEAs find applications in biomimetic robots, artificial muscles, and similar fields. When voltage is applied to the DEA, the dielectric layer undergoes compression and expansion due to electrostatic forces, which can lead to electrical breakdown. This phenomenon is closely related to the performance and lifespan of the DEA. To enhance stability and improve dielectric properties, a DEA Reservoir layer is introduced. Here, stability refers to the ability of the DEA to perform its functions even as the applied voltage increases. The Reservoir layer delays electrical breakdown and enhances stability due to its enhanced thickness. The proposed DEA in this paper is composed of a Reservoir layer and electrode layer. The Reservoir layer is placed between the electrode layers and is independently configured, not subjected to applied voltage like the electrode layers. The performance of the DEA was evaluated by varying the number of polymer layers in the Reservoir and electrode designs. Introducing the Reservoir layer improved the dielectric properties of the DEA and delayed electrical breakdown. Increasing the dielectric constant through the DEA Reservoir can enhance output characteristics in response to electrical signals. This approach can be utilized in various applications in wearable devices, artificial muscles, and other fields. Full article
(This article belongs to the Section Polymer Applications)
12 pages, 412 KiB  
Article
Exploring Risk Factors for Predicting 30-Day Postoperative Morbidity in Musculoskeletal Tumor Surgery
by Philip Heesen, Maria Elyes, Jan Domanski, Georg Schelling, Sören Könneker and Bruno Fuchs
J. Clin. Med. 2024, 13(9), 2681; https://doi.org/10.3390/jcm13092681 (registering DOI) - 02 May 2024
Abstract
Background: This study investigates the risk factors associated with postoperative complications in musculoskeletal tumor surgeries and evaluates the impact of benchmarking in enhancing surgical outcomes. Methods: Conducted at a tertiary referral center, this retrospective analysis included 196 patients who underwent surgeries [...] Read more.
Background: This study investigates the risk factors associated with postoperative complications in musculoskeletal tumor surgeries and evaluates the impact of benchmarking in enhancing surgical outcomes. Methods: Conducted at a tertiary referral center, this retrospective analysis included 196 patients who underwent surgeries for various musculoskeletal tumors, ranging from soft tissue to bone sarcomas. Patient and tumor characteristics, along with surgical interventions and outcomes, were comprehensively assessed using the Charlson Comorbidity Index and the Clavien-Dindo classification. Results: Key findings indicate that surgical reconstruction, ASA 3 status, bone tumor presence, and the need for multiple erythrocyte transfusions significantly increase postoperative morbidity. Notably, no significant correlation was found between the Charlson Comorbidity Index scores and the occurrence or severity of complications, challenging the utility of this index in predicting short-term surgical outcomes. Conclusions: This study highlights the importance of tailored surgical approaches and emphasizes rigorous preoperative assessments to mitigate risks and enhance patient care. Despite its insights, limitations include its retrospective nature and single-center scope, suggesting a need for broader, multicenter studies to generalize findings. Overall, our results underscore the necessity of integrating clinical assessments with benchmarking data to optimize outcomes in the complex field of musculoskeletal tumor surgery. Full article
(This article belongs to the Special Issue Clinical Management and Treatment of Orthopedic Oncology)
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35 pages, 5505 KiB  
Review
Ecdysterone and Turkesterone—Compounds with Prominent Potential in Sport and Healthy Nutrition
by Velislava Todorova, Stanislava Ivanova, Dzhevdet Chakarov, Krasimir Kraev and Kalin Ivanov
Nutrients 2024, 16(9), 1382; https://doi.org/10.3390/nu16091382 (registering DOI) - 02 May 2024
Abstract
The naturally occurring compounds ecdysterone and turkesterone, which are present in plants, including Rhaponticum carthamoides Willd. (Iljin), Spinacia oleracea L., Chenopodium quinoa Willd., and Ajuga turkestanica (Regel) Briq, are widely recognized due to their possible advantages for both general health and athletic [...] Read more.
The naturally occurring compounds ecdysterone and turkesterone, which are present in plants, including Rhaponticum carthamoides Willd. (Iljin), Spinacia oleracea L., Chenopodium quinoa Willd., and Ajuga turkestanica (Regel) Briq, are widely recognized due to their possible advantages for both general health and athletic performance. The current review investigates the beneficial biological effects of ecdysterone and turkesterone in nutrition, highlighting their roles not only in enhancing athletic performance but also in the management of various health problems. Plant-based diets, associated with various health benefits and environmental sustainability, often include sources rich in phytoecdysteroids. However, the therapeutic potential of phytoecdysteroid-rich extracts extends beyond sports nutrition, with promising applications in treating chronic fatigue, cardiovascular diseases, and neurodegenerative disorders. Full article
(This article belongs to the Section Sports Nutrition)
12 pages, 2271 KiB  
Article
Production of Margarine Fat Containing Medium- and Long-Chain Triacylglycerols by Enzymatic Interesterification of Peony Seed Oil, Palm Stearin and Coconut Oil Blends
by Man Zhang, Baocheng Xu, Dongkun Zhao, Mengqi Shen, Mengjie Li, Donghao Liu and Lili Liu
Foods 2024, 13(9), 1405; https://doi.org/10.3390/foods13091405 (registering DOI) - 02 May 2024
Abstract
This paper reports the preparation of margarine fat using Lipozyme TL IM as a catalyst and peony seed oil (PSO), palm stearin (PS) and coconut oil (CO) as raw materials. The results indicate that there were no significant changes in fatty acid composition [...] Read more.
This paper reports the preparation of margarine fat using Lipozyme TL IM as a catalyst and peony seed oil (PSO), palm stearin (PS) and coconut oil (CO) as raw materials. The results indicate that there were no significant changes in fatty acid composition before or after interesterification of the oil samples. However, the total amount of medium- and long-chain triglycerides (MLCTs) increased from 2.92% to 11.38% in sample E1 after interesterification, mainly including LaLaO, LaMO, LaPM, LaOO, LaPO and LaPP. Moreover, the slip melting point (SMP) of sample E1 decreased from 45.9 °C (B1) to 33.5 °C. The solid fat content (SFC) of all the samples at 20 °C was greater than 10%, indicating that they could effectively prevent oil exudation. After interesterification, the samples exhibited a β′ crystal form and could be used to prepare functional margarine. Full article
(This article belongs to the Special Issue Healthy Lipids for Food Processing)
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40 pages, 1889 KiB  
Review
Exotic Tetraquarks at the HL-LHC with : A High-Energy Viewpoint
by Francesco Giovanni Celiberto
Symmetry 2024, 16(5), 550; https://doi.org/10.3390/sym16050550 (registering DOI) - 02 May 2024
Abstract
We review the semi-inclusive hadroproduction of a neutral hidden-flavor tetraquark with light and heavy quark flavor at the HL-LHC, accompanied by another heavy hadron or a light-flavored jet. We make use of the novel TQHL1.0 determinations of leading-twist fragmentation functions to describe the [...] Read more.
We review the semi-inclusive hadroproduction of a neutral hidden-flavor tetraquark with light and heavy quark flavor at the HL-LHC, accompanied by another heavy hadron or a light-flavored jet. We make use of the novel TQHL1.0 determinations of leading-twist fragmentation functions to describe the formation mechanism of a tetraquark state within the next-to-leading order perturbative QCD. This framework builds on the basis of a spin physics-inspired model, taken as a proxy for the lowest-scale input of the constituent heavy-quark fragmentation channel. Then, all parton-to-tetraquark fragmentation functions are consistently obtained via the above-threshold DGLAP evolution in a variable-flavor number scheme. We provide predictions for a series of differential distributions calculated by the hands of the method, well-adapted to NLL/NLO+ hybrid-factorization studies, where the resummation of next-to-leading energy logarithms and beyond is included in the collinear picture. We provide corroborating evidence that high-energy observables sensitive to semi-inclusive tetraquark emissions at the HL-LHC exhibit a fair stability under radiative corrections, as well as MHOU studies. Our analysis constitutes a prime contact point between QCD resummations and the exotic matter. Full article

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