Late type II endoleaks (T2ELs) arising from the internal iliac artery (IIA) may present during follow-up after endovascular aortic repair (EVAR) of aortoiliac aneurysm and may warrant embolization if enlargement of the aneurysmal sac is demonstrated. When coverage of the IIA ostium has been made due to extensive iliac disease, access options can be challenging. Different treatment options have been reported over recent years, and a careful selection of the best one must be made based on the characteristics of each case. The present study reports a simple and reproducible sheathless percutaneous superior gluteal artery (SGA) access and provides a discussion based on a review of the existing literature on this topic. Full article

In order to identify the source and bioavailability of soil Cd in the alluvial geological high background area, 3799 topsoil samples and 140 root soil samples were collected from the Jiulong area on the south bank of Poyang Lake, Jiangxi Province. The results confidently indicate that the range of topsoil Cd content is 0.02~8.12 ppm, with an exceedance rate of 14.6%. It is noteworthy that exceedance points were mostly distributed in quaternary sediments. The geostatistical analysis clearly shows that the spatial distribution characteristic of topsoil Cd is higher in the north and lower in the south. The area with extremely high values (>90% quantile) is predominantly located in the tidal flat and low-lying areas of the mainstream of the Xinjiang River. The PCA analysis confirms that the main source of topsoil Cd is man-made activities related to industry and mining. Soil Cd is primarily derived from upstream industrial and mining discharge (58.5%), as revealed by the PMF model analysis. The active Cd content in root soil is 77 ppb, with higher levels observed in the north and lower levels in the south. These findings suggest a significant risk of Cd diffusion along the upstream stream and deposition in the low-lying parts of the north. It is worth noting that Cd’s bioavailability and active forms in paddy fields are the highest, which can have a detrimental effect on food security. The correlation analysis suggests that genetic sources primarily control the bioavailability of soil Cd, followed by soil physicochemical properties such as SOC, Fe-Al oxides, and soil texture. Preventing source pollution and cutting off water system transmission are effective methods for preventing and controlling soil Cd pollution. These methods ensure the safety of cultivated land in the lakeside area of Poyang Lake Plain. Full article

Food plants are the basis of human nutrition, but, in contaminated places, they can uptake contaminants. Environmental contamination and climate change can modify food quality; generally, they have a negative impact on and imply risks to human health. Heavy metals, like lead, arsenic, cadmium, and chromium, can be present at various environmental levels (soil, water, and atmosphere), and they are widely distributed in the world. Food plants can carry out heavy metal bioaccumulation, a defense pathway for plants, which is different for every plant species. Accumulation is frequent in the roots and the leaves, and heavy metals can be present in fruits and seeds; As and Cd are always present. In addition, other contaminants can bioaccumulate in food plants, including emerging contaminants, like persistent organic pollutants (POPs), pesticides, and microplastics. In food plants, these are present in the roots but also in the leaves and fruits, depending on their chemical structure. The literature published in recent years was examined to understand the distribution of contaminants among food plants. In the literature, old agronomical practices and new integrated technology to clean the water, control the soil, and monitor the crops have been proposed to mitigate contamination and produce high food quality and high food safety. Full article

To reveal the mechanism of hydraulic fracture initiation and propagation under the conditions of multiple perforations during horizontal well fracturing, we creatively conducted dual-hole fracturing experiments on small rock samples and established a two-dimensional model of a single cluster with multiple perforations in a horizontal well based on the extended finite element method using the fluid–solid coupling equation, which was combined with the basic theory of damage mechanics. The biggest difference from previous research is that this model does not consider the hypothesis of stress shadows and only focuses on studying the initiation and propagation of multiple perforations in one cluster. We studied the effects of perforation parameters, stress state, and injection flow rate on the initiation and propagation of hydraulic fractures using this model. The experimental and simulation results indicate that under multi-perforation conditions, the number of fractures depends on the number of perforations. The simulation results show that when the spacing between perforations increases or the number of perforations reduces, the initiation time of perforation is advanced and the interference between fractures weakens, which is conducive to the initiation and propagation of hydraulic fractures. As the stress difference increases, the initiation time of perforation becomes earlier and the deflection angle of the outermost fractures becomes smaller, which is conducive to the parallel expansion of the fractures. Moreover, although this has little impact on the morphology of fractures with the rise in flow rate in simulation, it is beneficial for improving the initiation and propagation speed of fractures. The length of fractures also increases significantly at the same time point. In addition, both the experiments and simulations revealed that an increase in the flow rate could accelerate the initiation time of fractures. The proposed model can guide fracturing construction to optimize the design of perforation spacing during horizontal well fracturing, which can contribute to reducing development costs and improving the final production. Full article

Swallowing disorders, or dysphagia, can lead to bolus aspiration in the airway, causing serious adverse health effects. Current clinical interventions for dysphagia are mainly empirical and often based on symptoms rather than etiology, of which a thorough understanding is still lacking. However, it is challenging to study the swallowing process that involves sequential structural motions and is inaccessible to standard visualization instruments. This study proposed an in vitro method to visualize swallowing hydrodynamics and identify the fundamental mechanisms underlying overflow aspirations. An anatomically accurate pharynx–epiglottis model was developed from patient-specific CT images of 623 µm isotropic resolution. A compliant half-pharynx cast was prepared to incorporate dynamic structures and visualize the flow dynamics in the mid-sagittal plane. Three locations of frequent overflow aspiration were identified: the epiglottis base, cuneiform tubular recesses, and the interarytenoid notch. Water had a consistently higher aspiration risk than a 1% w/v methylcellulose (MC) solution. The contracting–relaxing pharynx and flapping epiglottis spread the liquid film, causing a delayed esophageal entry and increased vallecular residual, which was more pronounced with the MC solution. Dispensing the liquid too slowly resulted in water aspiration, whereas this was not observed with the MC solution. An incomplete epiglottis inversion, such as horizontal or down-tilt 45°, aggravated the aspiration risks of water. This study suggests that it is practical to use anatomically accurate respiratory–digestive models to study the swallowing process by incorporating varying physiological details. Full article

This paper examines the tractability of multivariate approximation problems under the normalized error criterion for a zero-mean Gaussian measure in an average-case setting. The Gaussian measure is associated with a covariance kernel, which is represented by the tensor product of one-dimensional kernels corresponding to Euler and Wiener integrated processes with non-negative and nondecreasing smoothness parameters ${\left\{r_d\right\}}_{d\in \mathbb{N}}$. We give matching sufficient and necessary conditions for various concepts of tractability in terms of the asymptotic properties of the regularity parameters, except for (s, 0)-WT. Full article

This study investigated the impacts of students’ mood states and background sound levels on students’ sound perceptions and academic performance in four library rooms. The background sound level was measured for five days. Meanwhile, around 300 students were invited to participate in a survey of questions about their acoustic perceptions and mood states and a concentration test. Pearson correlation, one-way ANOVA, and two-way ANOVA were applied to establish the relationships between the LAeq, students’ mood states, acoustic perceptions, and concentration levels on both the individual level and the room level and to identify the interaction effect between the background sound levels and mood states on students’ acoustic perception and concentration. The results indicated that LAeq in learning spaces significantly impacted students’ acoustic satisfaction, but only at the room level. In contrast, mood states mainly influenced students’ sound perception and concentration at the individual level. Furthermore, this study reports significant interaction effects between mood state and LAeq on students’ sound perceptions and reveals different impacts of mood states due to different sound levels. These results could help improve occupants’ acoustic perceptions and performance in learning spaces in the future. Full article

Currently, in the digital era, critical infrastructure is increasingly exposed to cyber threats to their operation and security. This study explores the use of blockchain technology to address these challenges, highlighting its immutability, decentralization, and transparency as keys to strengthening the resilience of these vital structures. Through a methodology encompassing literature review, use-case analysis, and the development and evaluation of prototypes, the effective implementation of the blockchain in the protection of critical infrastructure is investigated. The experimental results reveal the positive impact of the blockchain on security and resilience, presenting a solid defense against cyber-attacks due to its immutable and decentralized structure, with a 40% reduction in security incidents. Despite the observed benefits, blockchain integration faces significant challenges in scalability, interoperability, and regulations. This work demonstrates the potential of the blockchain to strengthen critical infrastructure. It marks progress towards the blockchain’s practical adoption, offering a clear direction for future research and development in this evolving field. Full article

Human malignancies are one of the major health-related issues throughout the world and are anticipated to rise in the future. Despite huge investments made in anticancer drug development, limited success has been obtained and the average number of FDA approvals per year is declining. So, an increasing interest in drug repurposing exists. Metformin (MET) and aspirin (ASP) possess anticancer properties. This work aims to test the effect of these two drugs in combination on colorectal cancer (CRC) cells in vitro. The effects of MET and/or ASP on cell proliferation, viability, migratory ability, anchorage-independent growth ability (colony formation), and nutrient uptake were determined in two (HT-29 and Caco-2) human CRC cell lines. Individually, MET and ASP possessed antiproliferative, cytotoxic, and antimigratory effects and reduced colony formation in HT-29 cells (BRAF- and phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit α (PI3KCA)-mutant), although MET did not affect either ³H-deoxy-D-glucose or ¹⁴C-butyrate uptake and lactate production, and ASP caused only a small decrease in ¹⁴C-butyrate uptake. Moreover, in these cells, the combination of MET and ASP resulted in a tendency to an increase in the cytotoxic effect and in a potentiation of the inhibitory effect on colony formation, although no additive antiproliferative and antimigratory effects, and no effect on nutrient uptake and lactate production were observed. In contrast, MET and ASP, both individually and in combination, were almost devoid of effects on Caco-2 cells (BRAF- and PI3KCA-wild type). We suggest that inhibition of PI3K is the common mechanism involved in the anti-CRC effect of both MET, ASP and their combination and, therefore, that the combination of MET + ASP may especially benefit PI3KCA-mutant CRC cases, which currently have a poor prognostic. Full article

In the contemporary era, conventional energy sources like oil, coal, and natural gas overwhelmingly contribute 89.6% to global CO₂ emissions, intensifying environmental challenges. Recognizing the urgency of addressing climate concerns, a pivotal shift towards renewable energy, encompassing solar, wind, and biofuels, is crucial for bolstering environmental sustainability. Bioethanol, a globally predominant biofuel, offers a versatile solution, replacing gasoline or integrating into gasoline–ethanol blends while serving as a fundamental building block for various valuable compounds. This review investigates the dynamic landscape of biomass generations, drawing insightful comparisons between the first, second, third, and fourth generations. Amid the drive for sustainability, the deliberate focus on the initial generation of biomass, particularly corn, in bioethanol production is grounded in the current dependence on edible crops. The established utilization of first-generation biomass, exemplified by corn, underscores the necessity for a comprehensive examination of its advantages and challenges, allowing for a nuanced exploration of existing infrastructure and practices. To produce bioethanol from corn feedstock, various milling methods can be employed. Thus, this paper delves into a comparative assessment of dry-milling and wet-milling processes scrutinizing their efficiency, environmental impact, and economic feasibility. Full article

Background and Objectives: This study aimed to evaluate the mid-term effectiveness and safety of a combined ultrasound (US) and fluoroscopy (FL)-guided approach in comparison to US-guided and FL-guided caudal epidural steroid injections (CESI) for treating unilateral lower lumbar radicular pain. Materials and Methods: A total of 154 patients who underwent CESI between 2018 and 2022 were included. Patients were categorized into three groups based on the guidance method: combined US and FL (n = 51), US-guided (n = 51), and FL-guided (n = 52). The study design was retrospective case-controlled, utilizing patient charts and standardized forms to assess clinical outcomes, adverse events, complications during the procedures. Results: In all groups, Oswestry Disability Index and Verbal Numeric Scale scores improved at 1, 3, and 6 months after the last injection, with no significant differences between groups (p < 0.05). The treatment success rate at all time points was also similar among the groups. Logistic regression analysis showed that injection method, cause, sex, age, number of injections, and pain duration did not independently predict treatment success. Blood was aspirated before injection in 2% (n = 1), 13.5% (n = 7), and 4% (n = 2) of patients in the combined US and FL groups, FL-guided groups, and US-guided groups, respectively. Intravascular contrast spread was detected in one patient in the combined method groups and seven in the FL-guided groups. Conclusions: When comparing pain reduction and functional improvement, there was no significant difference between the three methods. The combined method took less time compared to using FL alone. The combined approach also showed a lower occurrence of intravascular injection compared to using FL alone. Moreover, blood vessels at the injection site can be identified with an ultrasound using the combined method. Given these advantages, it might be advisable to prioritize the combined US- and FL-guided therapy when administering CESI for patients with unilateral lumbar radicular pain. Full article

Patient-Reported Outcome Measures (PROMs), such as the six-item International Knee Documentation Committee Subjective Knee Form (IKDC-6), play a crucial role in assessing health conditions and guiding clinical decisions. Latent Growth Modeling (LGM) can be employed to understand recovery trajectories in patients post-operatively. Therefore, the purpose of this study was to assess LGM properties of the IKDC-6 in patients with knee pathologies that require surgical intervention and to assess differences between subgroups (i.e., sex and age). A cross-sectional study was conducted using the Surgical Outcome System (SOS) database with patients who had undergone knee arthroscopy. Our results found that preoperative scores did not influence the rate of change overtime. Perceived knee health improved over time, with varying rates among individuals. The adolescent age subgroup and male subgroup exhibited faster recovery rates compared to the older age subgroup and female subgroup. While initial hypotheses suggested IKDC-6 could serve as a prognostic tool, results did not support this. However, results indicated favorable outcomes irrespective of preoperative perceived knee impairment levels. This study provides valuable insights into recovery dynamics following knee surgery, emphasizing the need for personalized rehabilitation strategies tailored to individual patient characteristics. Full article

Peptides possessing antihypertensive attributes via inhibiting the angiotensin-converting enzyme (ACE) were derived through the enzymatic degradation of Trichiurus lepturus (ribbonfish) using alkaline protease. The resulting mixture underwent filtration using centrifugation, ultrafiltration tubes, and Sephadex G-25 gels. Peptides exhibiting ACE-inhibitory properties and DPPH free-radical-scavenging abilities were isolated and subsequently purified via LC/MS-MS, leading to the identification of over 100 peptide components. In silico screening yielded five ACE inhibitory peptides: FAGDDAPR, QGPIGPR, IFPRNPP, AGFAGDDAPR, and GPTGPAGPR. Among these, IFPRNPP and AGFAGDDAPR were found to be allergenic, while FAGDDAPRR, QGPIGPR, and GPTGPAGP showed good ACE-inhibitory effects. IC₅₀ values for the latter peptides were obtained from HUVEC cells: FAGDDAPRR (IC₅₀ = 262.98 μM), QGPIGPR (IC₅₀ = 81.09 μM), and GPTGPAGP (IC₅₀ = 168.11 μM). Peptide constituents derived from ribbonfish proteins effectively modulated ACE activity, thus underscoring their therapeutic potential. Molecular docking and modeling corroborated these findings, emphasizing the utility of functional foods as a promising avenue for the treatment and prevention of hypertension, with potential ancillary health benefits and applications as substitutes for synthetic drugs. Full article

The delivery of therapeutical molecules through the skin, particularly to its deeper layers, is impaired due to the stratum corneum layer, which acts as a barrier to foreign substances. Thus, for the past years, scientists have focused on the development of more efficient methods to deliver molecules to skin distinct layers. Microneedles, as a new class of biomedical devices, consist of an array of microscale needles. This particular biomedical device has been drawing attention due to its ability to breach the stratum corneum, forming micro-conduits to facilitate the passage of therapeutical molecules. The microneedle device has several advantages over conventional methods, such as better medication adherence, easiness, and painless self-administration. Moreover, it is possible to deliver the molecules swiftly or over time. Microneedles can vary in shape, size, and composition. The design process of a microneedle device must take into account several factors, like the location delivery, the material, and the manufacturing process. Microneedles have been used in a large number of fields from drug and vaccine application to cosmetics, therapy, diagnoses, tissue engineering, sample extraction, cancer research, and wound healing, among others. Full article

The study of extreme events (EEs) in photonics has expanded significantly due to straightforward implementation conditions. EEs have not been discussed systematically, to the best of our knowledge, in the chaotic dynamics of a Fabry–Perot laser with optical feedback, so we address this in the current contribution. Herein, we not only find EEs in all modes but also divide the EEs in total output into two categories for further discussion. The two types of EEs have similar statistical features to conventional rogue waves. The occurrence probability of EEs undergoes a saturation effect as the feedback strength increases. Additionally, we analyze the influence of feedback strength, feedback delay, and pump current on the probability of EEs defined by two criteria of EEs and find similar trends. We hope that this work contributes to a deep understanding and serves as inspiration for further research into various multimode semiconductor laser systems. Full article

The aim of this paper is to analyze the formative and evaluative activities involving statistical graphs in the new textbooks for Chilean rural multigrade education. The methodology is qualitative, at a descriptive level and uses the content analysis technique. The sample is made up of the six primary education textbooks distributed by the Ministry of Education for rural multigrade schools. The results show the predominance of the bar chart, semiotic level 3, the task of calculating and the personal context in both types of activities, although with respect to the reading level, it is evident that level 4 predominates in the formative activities and level 2 in the evaluative ones. According to the results, it is recommended to incorporate graphs proposed by the curricular guidelines of the Ministry of Education, which are absent in textbooks as well as to include evaluative activities that require reflection on the nature of the data, context, representation and conclusions obtained from them. Full article

Background: The diagnosis of depression in dementia patients leads to an increase in the burden of the disease. To treat depression in this patient group, antidepressants are frequently used; however, there is not any proof of their therapeutic effectiveness, and their use may be potentially harmful. This narrative review aims to summarize the existing evidence regarding the role of antidepressants in treating depression in dementia patients. Main text: A search was conducted in the PubMed, Excerpta Medica database (EMBASE), and Cochrane databases for randomized controlled trials and meta-analyses wherein antidepressants were given to dementia sufferers to address depression. Fifteen randomized controlled trials and seven meta-analyses were identified. Most well-designed blinded placebo-controlled trials reported a lack of effectiveness of antidepressants in treating depression in dementia patients. Among the seven metanalyses, two reported good efficacy of Selective serotonin reuptake inhibitors (SSRIs). However, two major Cochrane reviews reported little or no effectiveness and increased side effects of antidepressants in dementia patients. Conclusion: There is robust evidence regarding the lack of efficacy of antidepressants in treating depression in dementia patients. However, further well-designed Randomized controlled trials (RCTs,) using scales with good validity and reliability to diagnose depression in dementia patients, sufficient sample sizes, and detailed adverse effect profiles may help determine the rationale for their use. Full article

Astragalus polysaccharide (APS) derived from A. membranaceus plays a crucial role in traditional Chinese medicine. These polysaccharides have shown antitumor effects and are considered safe. Thus, they have become increasingly important in cancer immunotherapy. APS can limit the spread of cancer by influencing immune cells, promoting cell death, triggering cancer cell autophagy, and impacting the tumor microenvironment. When used in combination with other therapies, APS can enhance treatment outcomes and reduce toxicity and side effects. APS combined with immune checkpoint inhibitors, relay cellular immunotherapy, and cancer vaccines have broadened the application of cancer immunotherapy and enhanced treatment effectiveness. By summarizing the research on APS in cancer immunotherapy over the past two decades, this review elaborates on the anticancer mechanism of APS and its use in cancer immunotherapy and clinical trials. Considering the multiple roles of APS, this review emphasizes the importance of using APS as an adjunct to cancer immunotherapy and compares other polysaccharides with APS. This discussion provides insights into the specific mechanism of action of APS, reveals the molecular targets of APS for developing effective clinical strategies, and highlights the wide application of APS in clinical cancer therapy in the future. Full article

The article describes the selection of a permanent magnet synchronous machine design that could be implemented in a small wind turbine designed by the GUST student organization together with researchers working at the Technical University of Lodz. Based on measurements of the characteristics of available machines, eight initial designs of machines with different rotor designs were proposed. The size of the stator, the number of pairs of poles, and the dimensions of the magnets were used as initial parameters of the designed machines. The analysis was carried out about the K-index, the so-called index of benefits. The idea was to make the selected design as efficient as possible while keeping production costs and manufacturing time low. This paper describes how to select the best design of a permanent magnet synchronous generator intended to work with a small wind turbine. All generator parameters were selected keeping in mind the competition requirements, as the designed generator will be used in the author’s wind turbine. Based on the determined characteristics of the generator variants and the value of the K-index, a generator with a latent magnet rotor was selected as the best solution. The aforementioned K-index is a proprietary concept developed for the selection of the most suitable generator design. This paper did not use optimization methods; the analysis was only supported by the K-index. Full article

African American (AA) populations present with notably higher incidence and mortality rates from lung cancer in comparison to other racial groups. Here, we elucidated the contribution of long non-coding RNAs (lncRNAs) in the racial disparities and their potential clinical applications in both diagnosis and therapeutic strategies. AA patients had elevated plasma levels of MALAT1 and PVT1 compared with cancer-free smokers. Incorporating these lncRNAs as plasma biomarkers, along with smoking history, achieved 81% accuracy in diagnosis of lung cancer in AA patients. We observed a rise in MALAT1 expression, correlating with increased levels of monocyte chemoattractant protein-1 (MCP-1) and CD68, CD163, CD206, indicative of tumor-associated macrophages in lung tumors of AA patients. Forced MALAT1 expression led to enhanced growth and invasiveness of lung cancer cells, both in vitro and in vivo, accompanied by elevated levels of MCP-1, CD68, CD163, CD206, and KI67. Mechanistically, MALAT1 acted as a competing endogenous RNA to directly interact with miR-206, subsequently affecting MCP-1 expression and macrophage activity, and enhanced the tumorigenesis. Targeting MALAT1 significantly reduced tumor sizes in animal models. Therefore, dysregulated MALAT1 contributes to lung cancer disparities in AAs by modulating the tumor immune microenvironment through its interaction with miR-206, thereby presenting novel diagnostic and therapeutic targets. Full article

Life Cycle Assessment (LCA) and Life Cycle Cost Assessment (LCCA) are essential tools for environmental and economic assessment and decision-making in an evolving world with continuous climate change. In the same conditions, one of the most used and assessed solutions for facing climate change is using pervious pavements, with many papers proving its benefits. However, the literature has shown a need for more research on the LCA methodological aspects in the context of new green infrastructure. This research aims to review pervious pavements, LCA and LCCA combined, while discussing possible differences in boundaries, functional units, and other parameters. Thus, a string search was performed, leading to 89 documents. The main results indicate LCA is usually scope-bounded in the field of pervious pavements, with different benefits and characteristics, such as traffic impact, urban heat island effects, and carbonation. As for LCCA, private and public cost differentiation provide a scope definition and monetisation difficulties. In conclusion, both tools offer promising applications in pervious pavements. As a significant deliverable and recommendation of this paper, both LCA and LCCA theoretical frameworks were provided based on the benefits and specific characteristics included in the literature. These frameworks introduce novel ideas and perspectives, inviting further exploration and discussion. Full article