Since the beginning of the COVID-19 pandemic, different viral vector-based and mRNA vaccines directed against the SARS-CoV-2 “S” spike glycoprotein have been developed and have shown a good profile in terms of safety and efficacy. Nevertheless, an unbiased comparison of vaccination efficiency, including post-vaccination neutralizing activity, between the different vaccines remains largely unavailable. This study aimed to compare the efficacy of one mRNA (BNT162b2) and two non-replicating adenoviral vector vaccines (ChAdOx1 nCoV-19 and Sputnik V) in a cohort of 1120 vaccinated Palestinian individuals who received vaccines on an availability basis and which displayed a unique diversity of genetic characteristics. We assessed the level of anti-S antibodies and further determined the antibody neutralizing activity in 261 of those individuals vaccinated with BNT162b2a (121), ChAdOx1 (72) or Sputnik V (68). Our results showed no significant difference in the distribution of serum-neutralizing activity or S-antibody serum levels for the three groups of vaccines, proving equivalence in efficacy for the three vaccines under real-life conditions. In addition, none of the eight demographic parameters tested had an influence on vaccination efficacy. Regardless of the vaccine type, the vaccination campaign ultimately played a pivotal role in significantly reducing the morbidity and mortality associated with COVID-19 in Palestine. Full article

The reversibility of the covalent interaction between boronic acids and 1,2- or 1,3-diols has put the spotlight on this reaction for its potential in the development of sensors and for the fishing of bioactive glycoconjugates. In this work, we describe the investigation of this reaction for the reversible functionalization of the surface of CdSe/ZnS Quantum Rods (QRs). With this in mind, we have designed a turn-off Förster resonance energy transfer (FRET) system that ensures monitoring the extent of the reaction between the phenyl boronic residue at the meso position of a BODIPY probe and the solvent-exposed 1,2-diols on QRs’ surface. The reversibility of the corresponding boronate ester under oxidant conditions has also been assessed, thus envisioning the potential sensing ability of this system. Full article

In this paper, I examine the iconography, religious function and text–image relationship of one of the earliest illustrations of the apocryphal Visualization Sūtra, namely, the mural painting on the left (south) wall of Cave 20 at the Toyok Grottoes in Turfan created in the late sixth century. I study this mural with a structuralist approach to situate it within the overall pictorial program of the cave temple. I argue that this wall painting was designed as a visual and verbal cue to assist the meditating monks in situ to separately visualize the different individual visions constituting the “Thirteen Visualizations” taught in the sutra, excluding the five visions directly related to the Amitāyus Triad, namely, the eighth, ninth, tenth, eleventh and thirteenth visualizations. These five visualizations were likely facilitated by icons of the Amitāyus Triad placed in the center of the cave. The meditators started from the contemplations of the impure represented on the right (north) wall as preparational practices to eliminate their sins, improve their karma and thereby enhance their spiritual purity to a level appropriate for performing the Pure Land visualizations. They then turned to the left wall to perform the Pure Land visualizations represented there that end with the twelfth visualization: imagining oneself being reborn in Sukhāvatī. Continuing from the twelfth visualization, the meditators, in a state of meditational concentration, turned their faces to the rear wall to enter the Western Pure Land via the various lotus ponds represented on the rear wall. Full article

Persistent dizziness and balance deficits are common, often with unknown etiology. Persistent Postural-Perceptual Dizziness (3PD) is a relatively new diagnosis with symptoms that may include dizziness, unsteadiness, or non-vertiginous dizziness and be persistent the majority of time over a minimum of 90 days. The purpose of this case series was to investigate short-term outcomes of reducing dizziness symptoms using a manual therapy intervention focused on restoring mobility in the fascia using a pragmatically applied biomechanical approach, the Fascial Manipulation^® method (FM^®), in patients with 3PD. The preliminary prospective case series consisted of twelve (n = 12) patients with persistent complaints of dizziness who received systematic application of manual therapy to improve fascial mobility after previously receiving vestibular rehabilitation. The manual therapy consisted of strategic assessment and palpation based on the model proposed in the FM^® Stecco Method. This model utilizes tangential oscillations directed toward the deep fascia at strategic points. Six males (n = 6) and females (n = 6) were included with a mean age of 68.3 ± 19.3 years. The average number of interventions was 4.5 ± 0.5. Nonparametric paired sample t-tests were performed. Significant improvements were observed toward the resolution of symptoms and improved outcomes. The metrics included the Dizziness Handicap Inventory and static and dynamic balance measures. The Dizziness Handicap Inventory scores decreased (i.e., improved) by 43.6 points (z = −3.1 and p = 0.002). The timed up and go scores decreased (i.e., improved) by 3.2 s (z = −2.8 and p = 0.005). The tandem left increased (i.e., improved) by 8.7 s (z = 2.8 and p = 0.005) and the tandem right increased (i.e., improved) by 7.5 s (z = 2.8 and p = 0.005). Four to five manual therapy treatment sessions appear to be effective for short-term improvements in dizziness complaints and balance in those with 3PD. These results should be interpreted with caution as future research using rigorous methods and a control group must be conducted. Full article

In many countries, some form of genetic screening is offered to all or part of the population, either in the form of well-organized screening programs or in a less formalized way. Screening can be offered at different phases of life, such as preconception, prenatal, neonatal and later in life. Screening should only be offered if the advantages outweigh the disadvantages. Technical innovations in testing and treatment are driving changes in the field of prenatal and neonatal screening, where many jurisdictions have organized population-based screening programs. As a result, a greater number and wider range of conditions are being added to the programs, which can benefit couples’ reproductive autonomy (preconception and prenatal screening) and improve early diagnosis to prevent irreversible health damage in children (neonatal screening) and in adults (cancer and cascade screening). While many developments in screening are technology-driven, citizens may also express a demand for innovation in screening, as was the case with non-invasive prenatal testing. Relatively new emerging issues for genetic screening, especially if testing is performed using DNA sequencing, relate to organization, data storage and interpretation, benefit–harm ratio and distributive justice, information provision and follow-up, all connected to acceptability in current healthcare systems. Full article

The widespread application of CAD/CAM technology in contemporary dentistry led to the development of promising restorative materials, such as resin composite blocks (RCBs). Thus, the present study aims to evaluate the mechanical properties of RCBs, comparing this material to the direct composite resin from the same manufacturer. Samples retrieved from three CAD/CAM resin composite blocks (Tetric CAD (TC), Ivoclar Vivadent, Grandio blocs (GB), VOCO GmbH and Brilliant Crios (BC), Coltene/Whaledent) and four direct composite resins (Tetric EvoCeram (TEC), Ivoclar Vivadent, GrandioSO (GS), VOCO GmbH, Brilliant EverGlow Translucent (BET) and Universal Shade (BEU), Coltene/Whaledent) were submitted to three-point bending flexural test and Vickers microhardness test. The resulting data of the flexural strength were analyzed using one-way ANOVA considering Bonferroni correction for post hoc tests (α = 0.05). The flexural modulus and Vickers microhardness results were analyzed using Welch’s ANOVA considering Games–Howell correction for post hoc tests (α = 0.05). Regarding results, flexural strength and flexural modulus values ranged from 81.1 MPa (BEU) to 246.5 MPa (GB) and 10.6 GPa (BEU) to 20.3 GPa (GB), respectively. GS (121.2) and GB (136.2) groups were associated with the highest microhardness values. According to the post hoc tests, statistically significant differences in flexure strength were found in RCBs (BC, GB, and TC) compared to all direct composite resins. Flexural modulus and Vickers microhardness of RCBs (BC, GB, TC) were also significantly different from the direct composite resin (BET, BED, and TEC), except when comparing GS and GB for microhardness. In conclusion, differences between RCBs and direct composite resins were observed regarding flexural strength, flexural modulus, and microhardness, revealing that RCBs have enhanced mechanical properties compared to direct composite resins. Full article

Using an optimality theoretic analysis, this study offers a conception of the problem of plural realization in Eastern Andalusian Spanish (EAS) where plural suffix /s/ was deleted diachronically that differs from other accounts that assign the EAS plural an underlying suffixal /s/ synchronically. Using alignment constraints, we argue that plural /s/ does not appear in the underlying form synchronically in EAS, but that instead the plural morpheme is represented by a floating [–ATR]PL feature that aligns to the right edge of the word and spreads left. The [–ATR] feature, represented phonetically as a laxing or opening of vowels, applies to all mid vowels, low vowels in word final position, and combines with vowel epenthesis to explain Eastern Andalusian pluralization tendencies in words with final consonants. We discuss the behavior of high vowels, which can be transparent to harmony, and focus in particular on the plural of words that end in a final stressed vowel that have been rarely discussed in the EAS literature. We develop an optimality-theoretic analysis on the Granada variety and extend that analysis to other varieties with somewhat different patterns. Full article

Organic soil amendments are a sustainable option for modifying soil structure and improving plant performance in the face of abiotic stressors such as drought and soil salinity. Of these amendments, biochar and compost have the added benefits of carbon sequestration and waste recycling. Establishment studies were conducted on tall fescue (Festuca arundinacea Schreb.) (syn., Schedonorus arundinaceus (Schreb.) Dumort and Lolium arundinaceum (Scop.) Holub) to assess the potential inhibition of establishment by compost and biochar products. Both green waste and biosolid compost impaired establishment rates, while biochar did not. In the field study, the green waste treatments were slower to reach 50% coverage than the untreated control or when biochar was added to the soil, but all treatments reached 75% and final coverage at a similar rate. Field application of compost had a positive effect on final root length and volume but a negative effect on tall fescue roots in the greenhouse. The negative effect of higher salts and volatiles in the biosolids compost was reduced when biosolids and biochar were incorporated into the soil simultaneously. This work represents one of the only large-scale field studies on turfgrass establishment comparing the impact of biochar and compost products on turfgrass establishment. Full article

Scientific research on romantic love has been relatively sparse but is becoming more prevalent, as it should. Unfortunately, several misconceptions about romantic love are becoming entrenched in the popular media and/or the scientific community, which hampers progress. Therefore, I refute six misconceptions about romantic love in this article. I explain why (1) romantic love is not necessarily dyadic, social, or interpersonal, (2) love is not an emotion, (3) romantic love does not just have positive effects, (4) romantic love is not uncontrollable, (5) there is no dedicated love brain region, neurotransmitter, or hormone, and (6) pharmacological manipulation of romantic love is not near. To increase progress in our scientific understanding of romantic love, I recommend that we study the intrapersonal aspects of romantic love including the intensity of love, that we focus our research questions and designs using a component process model of romantic love, and that we distinguish hypotheses and suggestions from empirical findings when citing previous work. Full article

Despite the high prevalence of mental health difficulties during the period of emerging adulthood and the availability of mental health resources, young adults are reluctant to seek professional psychological help. A significant contributor to this treatment gap is the inadequate levels of mental health literacy (MHL). The present study aimed to investigate the association between MHL with attitudes toward mental illness and the self-stigma of seeking psychological treatment among university students. The sample consisted of 485 university students (24.5% males, 75.5% females) with a mean age of 19.54 years (SD = 1.45) drawn from a regional university in Greece. MHL, attitudes towards severe mental illness, and self-stigma of help-seeking were assessed using the Mental Health Literacy Scale (MHLS), the Attitudes towards Severe Mental Illness (ASMI), and the Self-Stigma of Seeking Help Scale (SSOSH), respectively. MHLS was positively correlated with three out of four subscales of ASMI, namely stereotyping, optimism, and coping, and negatively related to SSOSH. Multivariate linear regression analysis adjusting for various confounders showed that students with higher MHL were more likely to report non-stigmatizing attitudes towards mental illness and lower self-stigma of help-seeking from mental health professionals. According to our findings, higher MHL was related to more positive views regarding mental illness and lower self-stigma of help-seeking. To lessen the self-stigma of seeking professional help, MHL must be addressed as an important component of psychoeducational interventions at universities aiming to support students’ help-seeking intentions and practices. Full article

This study explores STEM students’ perspectives on service-learning and story-telling activities to enhance community engagement and advance gender equality, investigating their impact on students’ perceptions, experiences, and understanding of gender dynamics within rural communities. Through qualitative analysis of interviews, reflective journals, and participatory videos, this study explores the transformative potential of service-learning and storytelling initiatives in empowering rural women, challenging traditional societal roles, and advocating for equal opportunities, particularly in STEM disciplines. Findings reveal the multifaceted benefits of these activities, including the development of empathy, cultural awareness, leadership skills, and a commitment to social justice among participating students. This study highlights the importance of integrating service-learning and storytelling into STEM education to cultivate inclusive practices, promote community development, and advance gender equality in rural settings. Full article

The recent emergence of generative AI technologies is beginning to shape workforce hiring practices. The shift towards skills-based hiring over degree-based hiring has sparked concerns over the ability of college graduates to be prepared for their career roles. One approach to equip students to work with technology and adapt to rapidly changing environments is the development of an entrepreneurial mindset. One way to cultivate entrepreneurial thinking is through the participatory action research methodology, photovoice. This study explores how photovoice promotes discovery, evaluation, and exploitation of opportunities in university engineering classrooms. For this study, a literature review was conducted to identify, evaluate, and interpret available research. For the review, a five-step process was used. This process included defining a search criterion, constructing a Boolean logic search query, inserting the query into multiple academic search engines/databases, screening and selecting articles, and categorizing and mapping the literature. The review’s findings were organized based on the type of study, participants, duration of study and photovoice interventions used, study outcomes, and entrepreneurial mindset development. The results discussed in this paper offer insights, guidance, recommendations, and future directions for engineering education research. Full article

Wildfires pose a direct threat to the property, life, and well-being of the population of Montana, USA, and indirectly to their health through hazardous smoke and gases emitted into the atmosphere. Studies have shown that elevated levels of particulate matter cause impacts to human health ranging from early death, to neurological and immune diseases, to cancer. Although there is currently a network of ground-based air quality sensors (n = 20) in Montana, the geographically sparse network has large gaps and lacks the ability to make accurate predictions for air quality in many areas of the state. Using the random forest method, a predictive model was developed in the Google Earth Engine (GEE) environment to estimate PM2.5 concentrations using satellite-based aerosol optical depth (AOD), dewpoint temperature (DPT), relative humidity (RH), wind speed (WIND), wind direction (WDIR), pressure (PRES), and planetary-boundary-layer height (PBLH). The validity of the prediction model was evaluated using 10-fold cross validation with a R² value of 0.572 and RMSE of 9.98 µg/m³. The corresponding R² and RMSE values for ‘held-out data’ were 0.487 and 10.53 µg/m³. Using the validated prediction model, daily PM2.5 concentration maps (1 km-resolution) were estimated from 2012 to 2023 for the state of Montana. These concentration maps are accessible via an application developed using GEE. The product provides valuable insights into spatiotemporal trends of PM2.5 concentrations, which will be useful for communities to take appropriate mitigation strategies and minimize hazardous PM2.5 exposure. Full article

Document-oriented databases, a type of Not Only SQL (NoSQL) database, are gaining popularity owing to their flexibility in data handling and performance for large-scale data. MongoDB, a typical document-oriented database, is a database that stores data in the JSON format, where the upper field involves lower fields and fields with the same related parent. One feature of this
document-oriented database is that data are dynamically stored in an arbitrary location without explicitly defining a schema in advance. This flexibility violates the above property and causes difficulties for application program readability and database maintenance. To address these issues, we propose a reconstruction support method for document structures in MongoDB. The method uses the strength of the Has-A relationship between the parent and child fields, as well as the similarity of field names in the MongoDB documents in natural language processing, to reconstruct the data structure in MongoDB. As a result, the method transforms the parent and child fields into more
coherent data structures. We evaluated our methods using real-world data and demonstrated their MongoDBeffectiveness. Full article

In our study, we investigate the phenomenon of information loss, as measured by the Kullback–Leibler divergence, in a many-fermion system, such as the Lipkin model. Information loss is introduced as the number N of particles increases, particularly when the system is in a mixed state. We find that there is a significant loss of information under these conditions. However, we observe that this loss nearly disappears when the system is in a pure state. Our analysis employs tools from information theory to quantify and understand these effects. Full article

This paper presents a novel deep-learning network designed to detect intervals of jump discontinuities in single-variable piecewise smooth functions from their noisy samples. Enhancing the accuracy of jump discontinuity estimations can be used to find a more precise overall approximation of the function, as traditional approximation methods often produce significant errors near discontinuities. Detecting intervals of discontinuities is relatively straightforward when working with exact function data, as finite differences in the data can serve as indicators of smoothness. However, these smoothness indicators become unreliable when dealing with highly noisy data. In this paper, we propose a deep-learning network to pinpoint the location of a jump discontinuity even in the presence of substantial noise. Full article

Demographic changes have led to an increase in older people in prisons. Whereas the rehabilitative process of younger offenders is geared towards their reintegration into the labour market, successful ageing should be a policy aim for older prisoners. This study explores how older incarcerated persons view their ageing. A qualitative study using a written survey with only the single question What does ageing in prison mean to you? was conducted in Bavaria, Germany. A total of 64 prisoners (61 male, 3 female) supplied answers varying in length from a few words to several pages. The thematic analysis revealed that together with health concerns, social relations and everyday activities, the uncertainty of the future was a central focus point for the older adults in prison. The authors propose that a positive vision of the future needs to be included in any model of successful ageing. If successful ageing is used as an aim for older prisoners, more attention needs to be paid to support interventions during and after the release process. Full article

This study endeavors to automate the assessment of competencies within the domain of entrepreneurship, specifically targeting the augmentation of entrepreneurial cognition and conduct within universities in German rural regions, like Lower Franconia. Employing methods, including literature analyses and expert interviews, we formulated and validated an entrepreneurship competence profile and accompanying self-assessment tool. The ensuing evaluative framework is poised for seamless integration into learning management systems, thereby facilitating intelligent competence monitoring within educational environments. Purpose: The aim of this thesis is to develop an automated competence assessment procedure in the field of entrepreneurship. This can be used in the university environment in the long term to promote and teach entrepreneurial thinking and behavior in order to sustainably improve the quality of learning outcomes and achieve targeted promotion of entrepreneurship. Methodology: Based on a relevant literature analysis, four guideline-based expert interviews were created and conducted. The results of the interviews were compiled and validated in a structured competence profile (entrepreneurship competence profile). Based on this competence catalog for entrepreneurs, an empirically valid self-test was created using standard psychometric questionnaire construction methods. Results: The entrepreneurship competence profile and a consequential empirically validated self-test for competence assessment were created. This test provides the basis for the long-term competence development of students and can further be embedded automatically into a learning management system (LMS) as part of intelligent competence monitoring, which allows for the recording of competencies for each student and the individual incorporation of gap closure into the curriculum. Originality/value: In previous research, there were no competence profiles or competence assessment procedures in the field of entrepreneurship that derived relevant competencies directly from actors within this environment. This work illustrates the development of a competence assessment procedure for entrepreneurs and shows which methods can be used to close prevailing research gaps in the field of intelligent competence monitoring. Full article

A lot of time and effort is put into reducing waiting times in organizational life. However, jobs can include phases of waiting. The aim of this conceptual paper is to analyze waiting on the job level and provide a theoretical rationale for individual management of waiting times of employees. Wait crafting is introduced based on (job) crafting and its advantages for individuals and organizations outlined. Steps towards integrating the possibility of job crafting and needs for future research are indicated. Full article