The 2023 MDPI Annual Report has
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27 pages, 6171 KiB  
Article
Economic and Accessible Portable Homemade Magnetic Hyperthermia System: Influence of the Shape, Characteristics and Type of Nanoparticles in Its Effectiveness
by Teresa Castelo-Grande, Paulo A. Augusto, Lobinho Gomes, Ana Rita Castro Lopes, João Pedro Araújo and Domingos Barbosa
Materials 2024, 17(10), 2279; https://doi.org/10.3390/ma17102279 (registering DOI) - 11 May 2024
Abstract
Currently, one of the main causes of death in the world is cancer; therefore, it is urgent to obtain a precocious diagnosis, as well as boost research and development of new potential treatments, which should be more efficient and much less invasive for [...] Read more.
Currently, one of the main causes of death in the world is cancer; therefore, it is urgent to obtain a precocious diagnosis, as well as boost research and development of new potential treatments, which should be more efficient and much less invasive for the patient. Magnetic hyperthermia (MH) is an emerging cancer therapy using nanoparticles, which has proved to be effective when combined with chemotherapy, radiotherapy and/or surgery, or even by itself, depending on the type and location of the tumor’s cells. This article presents the results obtained by using a previously developed economic homemade hyperthermia device with different types of magnetite nanoparticles, with sizes ranging between 12 ± 5 and 36 ± 11 nm and presenting different shapes (spherical and cubic particles). These magnetic nanoparticles (MNPs) were synthesized by three different methods (co-precipitation, solvothermal and hydrothermal processes), with their final form being naked, or possessing different kinds of covering layers (polyethylene glycol (PEG) or citric acid (CA)). The parameters used to characterize the heating by magnetic hyperthermia, namely the Specific Absorption Rate (SAR) and the intrinsic loss power (ILP), have been obtained by two different methods. Among other results, these experiments allowed for the determination of which synthesized MNPs showed the best performance concerning hyperthermia. From the results, it may be concluded that, as expected, the shape of MNPs is an important factor, as well as the time that the MNPs can remain suspended in solution (which is directly related to the concentration and covering layer of the MNPs). The MNPs that gave the best results in terms of the SAR were the cubic particles covered with PEG, while in terms of total heating the spherical particles covered with citric acid proved to be better. Full article
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35 pages, 779 KiB  
Review
Deep Time Series Forecasting Models: A Comprehensive Survey
by Xinhe Liu and Wenmin Wang
Mathematics 2024, 12(10), 1504; https://doi.org/10.3390/math12101504 (registering DOI) - 11 May 2024
Abstract
Deep learning, a crucial technique for achieving artificial intelligence (AI), has been successfully applied in many fields. The gradual application of the latest architectures of deep learning in the field of time series forecasting (TSF), such as Transformers, has shown excellent performance and [...] Read more.
Deep learning, a crucial technique for achieving artificial intelligence (AI), has been successfully applied in many fields. The gradual application of the latest architectures of deep learning in the field of time series forecasting (TSF), such as Transformers, has shown excellent performance and results compared to traditional statistical methods. These applications are widely present in academia and in our daily lives, covering many areas including forecasting electricity consumption in power systems, meteorological rainfall, traffic flow, quantitative trading, risk control in finance, sales operations and price predictions for commercial companies, and pandemic prediction in the medical field. Deep learning-based TSF tasks stand out as one of the most valuable AI scenarios for research, playing an important role in explaining complex real-world phenomena. However, deep learning models still face challenges: they need to deal with the challenge of large-scale data in the information age, achieve longer forecasting ranges, reduce excessively high computational complexity, etc. Therefore, novel methods and more effective solutions are essential. In this paper, we review the latest developments in deep learning for TSF. We begin by introducing the recent development trends in the field of TSF and then propose a new taxonomy from the perspective of deep neural network models, comprehensively covering articles published over the past five years. We also organize commonly used experimental evaluation metrics and datasets. Finally, we point out current issues with the existing solutions and suggest promising future directions in the field of deep learning combined with TSF. This paper is the most comprehensive review related to TSF in recent years and will provide a detailed index for researchers in this field and those who are just starting out. Full article
17 pages, 2213 KiB  
Article
Genetic Variants Underlying Plasticity in Natural Populations of Spadefoot Toads: Environmental Assessment versus Phenotypic Response
by Andrew J. Isdaner, Nicholas A. Levis, Ian M. Ehrenreich and David W. Pfennig
Genes 2024, 15(5), 611; https://doi.org/10.3390/genes15050611 (registering DOI) - 11 May 2024
Abstract
Many organisms facultatively produce different phenotypes depending on their environment, yet relatively little is known about the genetic bases of such plasticity in natural populations. In this study, we describe the genetic variation underlying an extreme form of plasticity––resource polyphenism––in Mexican spadefoot toad [...] Read more.
Many organisms facultatively produce different phenotypes depending on their environment, yet relatively little is known about the genetic bases of such plasticity in natural populations. In this study, we describe the genetic variation underlying an extreme form of plasticity––resource polyphenism––in Mexican spadefoot toad tadpoles, Spea multiplicata. Depending on their environment, these tadpoles develop into one of two drastically different forms: a carnivore morph or an omnivore morph. We collected both morphs from two ponds that differed in which morph had an adaptive advantage and performed genome-wide association studies of phenotype (carnivore vs. omnivore) and adaptive plasticity (adaptive vs. maladaptive environmental assessment). We identified four quantitative trait loci associated with phenotype and nine with adaptive plasticity, two of which exhibited signatures of minor allele dominance and two of which (one phenotype locus and one adaptive plasticity locus) did not occur as minor allele homozygotes. Investigations into the genetics of plastic traits in natural populations promise to provide novel insights into how such complex, adaptive traits arise and evolve. Full article
(This article belongs to the Special Issue Genomics of Evolution and Adaptation in Animals)
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11 pages, 10190 KiB  
Review
Diagnostics of Exercise-Induced Laryngeal Obstruction Using Machine Learning: A Narrative Review
by Rune Mæstad, Haakon Kristian Kvidaland, Hege Clemm, Ola Drange Røksund and Reza Arghandeh
Electronics 2024, 13(10), 1880; https://doi.org/10.3390/electronics13101880 (registering DOI) - 11 May 2024
Abstract
Objective: This paper explores machine learning methods for exercise-induced laryngeal obstruction (EILO) diagnostics. Traditional diagnostic approaches like CLE scoring face subjectivity, limiting precise objective assessments. Machine learning is introduced as a theoretical solution to potentially overcome these limitations and improve diagnostic precision. Methods: [...] Read more.
Objective: This paper explores machine learning methods for exercise-induced laryngeal obstruction (EILO) diagnostics. Traditional diagnostic approaches like CLE scoring face subjectivity, limiting precise objective assessments. Machine learning is introduced as a theoretical solution to potentially overcome these limitations and improve diagnostic precision. Methods: A narrative review was conducted to explore the integration of machine learning techniques in the diagnostics of EILO. Result: Three machine learning methods for the segmentation of laryngeal images were discovered: fully convolutional network, Mask R-CNN, and 3D VOSNet. Our findings reveal that the integration of machine learning with EILO diagnostics remains a largely untapped research domain, providing significant room for further exploration. Conclusions: The integration of ML techniques for EILO diagnostics has the potential to be a helpful tool for clinicians. The application of computer vision ML methods, such as image segmentation, to delineate laryngeal structures paves the way for a more objective assessment. While challenges persist, especially in differences in patients’ laryngeal anatomy, the synergy of ML and medical expertise is an important field to explore in the years to come. Full article
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19 pages, 1035 KiB  
Review
Review on Dust Control Technologies in Coal Mines of China
by Rongting Huang, Yichun Tao, Jianglin Chen, Shihang Li and Shiyuan Wang
Sustainability 2024, 16(10), 4038; https://doi.org/10.3390/su16104038 (registering DOI) - 11 May 2024
Abstract
China faces a challenge in the sustainable development of the coal industry due to pneumoconiosis problems. Dust control technologies are crucial for safe production and miners’ health, ensuring the industry’s longevity. This article reviews the development process of dust prevention and control in [...] Read more.
China faces a challenge in the sustainable development of the coal industry due to pneumoconiosis problems. Dust control technologies are crucial for safe production and miners’ health, ensuring the industry’s longevity. This article reviews the development process of dust prevention and control in underground coal mines in China, summarizes various technologies, and divides them into dust suppression, open-space dust reduction, and mine dust collectors according to different stages and environments of use. In dust suppression technologies, coal-seam water injection can reduce total dust generation by 60%, wet rock drilling can reduce drilling dust in the presence of stable water sources and high-pressure bearing equipment, and water-seal blasting can reduce blasting dust by 50–70%. In open-space dust reduction technologies, spray dust suppression can remove total dust by 50–95% and the removal efficiencies of foam dedusting for total and respirable dust are reported to reach 95% and 85% under the right conditions, respectively. In dust collector technologies, dry collectors can remove 80–95% of total dust. Wet collectors achieve up to 90% efficiency, dependent on water supply and waste processing. This article also discusses vapor heterogeneous condensation technology as a promising method for improving respirable dust removal in humid mine environments. Full article
19 pages, 9180 KiB  
Article
In-Situ Grown Nanohydroxyapatite on Graphene Oxide Nanoscrolls for Modulated Physicochemical Properties of Poly (Caprolactone) Composites
by Lillian Tsitsi Mambiri, Gabrielle Broussard, Ja’Caleb Smith and Dilip Depan
Macromol 2024, 4(2), 285-303; https://doi.org/10.3390/macromol4020017 (registering DOI) - 11 May 2024
Abstract
Polymer composites with exceptional bioactivity and controlled in vitro degradation are crucial in tissue engineering. A promising approach involves combining graphene oxide nanoscrolls (GONSs) and nanohydroxyapatite (nHA) with polycaprolactone (PCL). The synergy of these components enables the mineralization of nHA within GONSs through [...] Read more.
Polymer composites with exceptional bioactivity and controlled in vitro degradation are crucial in tissue engineering. A promising approach involves combining graphene oxide nanoscrolls (GONSs) and nanohydroxyapatite (nHA) with polycaprolactone (PCL). The synergy of these components enables the mineralization of nHA within GONSs through a two-step process: first, oxygen-containing anionic groups in the GONSs anchor Ca2+ ions, followed by the formation of dispersed nHA through chelation with CaHPO42− via electrovalent bonding. A thermal analysis of the scaffolds’ morphology and microstructure was conducted via DSC and SEM imaging. Its enhanced physical properties are attributed to interactions between PCL and nHA–GONSs, as confirmed by an FTIR analysis showing strong interfacial bonding. Enzymatic degradation studies demonstrated reduced weight loss in PCL–nHA–GONS composites over 21 days, highlighting GONSs’ role in enhancing dimensional stability and reinforcement. An EDS analysis post-degradation revealed increased Ca2+ deposition on scaffolds with nHA–GONSs, indicating improved biopolymer–bioceramic interaction facilitated by the GONSs’ scrolled structure. This research offers a straightforward yet effective method for functionalizing GONSs with biologically beneficial nHA, potentially advancing graphene-based biomaterial development. Full article
(This article belongs to the Collection Advances in Biodegradable Polymers)
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15 pages, 7222 KiB  
Article
Recycled-Textile-Waste-Based Sustainable Bricks: A Mechanical, Thermal, and Qualitative Life Cycle Overview
by Hafsa Jamshaid, Ambar Shah, Muhammad Shoaib and Rajesh Kumar Mishra
Sustainability 2024, 16(10), 4036; https://doi.org/10.3390/su16104036 (registering DOI) - 11 May 2024
Abstract
The textile industry, renowned for its comfort-providing role, is undergoing a significant transformation to address its environmental impact. The escalating environmental impact of the textile industry, characterised by substantial contributions to global carbon emissions, wastewater, and the burgeoning issue of textile waste, demands [...] Read more.
The textile industry, renowned for its comfort-providing role, is undergoing a significant transformation to address its environmental impact. The escalating environmental impact of the textile industry, characterised by substantial contributions to global carbon emissions, wastewater, and the burgeoning issue of textile waste, demands urgent attention. This study aims at identifying the feasibility of the future use of textile scraps in the construction and architecture industry by analysing the effect of different binders. In this study, synthetic knitted post-consumer-waste fabrics were taken from a waste market for use as a reinforcement, and different binders were used as the matrix. In the experiment phase, the waste fabrics were mixed with synthetic binders and hydraulic binders to form brick samples. The mechanical and thermal properties of these samples were tested and compared with those of clay bricks. In terms of mechanical properties, unsaturated polyester resin (UPR) samples showed the highest mechanical strength, while acrylic glue (GL) samples had the lowest mechanical strength. White cement (WC) samples showed moderate mechanical properties. Through several tests, it was observed that UPR samples showed the highest values of tensile, bending, and compressive strengths, i.e., 0.111 MPa, 0.134 MPa, and 3.114 MPa, respectively. For WC, the tensile, bending, and compressive strengths were 0.064 MPa, 0.106 MPa, and 2.670 MPa, respectively. For GL, the least favourable mechanical behaviour was observed, i.e., 0.0162 MPa, 0.0492 MPa, and 1.542 MPa, respectively. In terms of thermal conductivity, WC samples showed exceptional resistance to heat transfer. They showed a minimum temperature rise of 54.3 °C after 15 min, as compared to 57.3 °C for GL-based samples and 58.1 °C for UPR. When it comes to polymeric binders, UPR showed better thermal insulation properties, whereas GL allowed for faster heat transfer for up to 10 min of heating. This study explores a circular textile system by assessing the potential of using textile waste as a building material, contributing to greener interior design. This study demonstrated the usefulness of adding short, recycled PET fibres as a reinforcement in UPR composites. The use of the PET fibre avoids the need to use a surface treatment to improve interfacial adhesion to the UPR matrix because of the chemical affinity between the two polyesters, i.e., the PET fibre and the unsaturated polyester resin. This can find application in the construction field, such as in the reinforcement of wooden structural elements, infill walls, and partition walls, or in furniture or for decorative purposes. Full article
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13 pages, 972 KiB  
Article
The Impact of Technological Innovation on Agricultural Green Total Factor Productivity: The Mediating Role of Environmental Regulation in China
by Lihuan Huang and Ying Ping
Sustainability 2024, 16(10), 4035; https://doi.org/10.3390/su16104035 (registering DOI) - 11 May 2024
Abstract
This study delves into the effects of agricultural technological innovation on agricultural green total factor productivity (AGTFP) and the intermediating role of environmental regulation (ER) in 30 Chinese provinces from 2010 to 2021. Employing mediation analysis methods such as the three-step approach, Sobel–Goodman [...] Read more.
This study delves into the effects of agricultural technological innovation on agricultural green total factor productivity (AGTFP) and the intermediating role of environmental regulation (ER) in 30 Chinese provinces from 2010 to 2021. Employing mediation analysis methods such as the three-step approach, Sobel–Goodman test, and Bootstrap methods, the findings are robust: technological innovation significantly enhances AGTFP, as evidenced by a 1% level significant coefficient of 0.030. Additionally, ER acts as a potent mediator, where its inclusion as an independent variable alongside agricultural technological innovation (AST) boosts the coefficient to 0.031, further confirming its synergistic effect on AGTFP. These data points underline the importance of innovation in agricultural sustainability and the reinforcing role of environmental regulation. Consequently, this study advocates for intensified agricultural innovation support, tailored environmental regulation policies, augmented environmental education, and a meticulous evaluation system for environmental legislation to foster sustainable agricultural practices. Full article
16 pages, 4869 KiB  
Article
Channel Knowledge Map Construction Based on a UAV-Assisted Channel Measurement System
by Yanheng Qiu, Xiaomin Chen, Kai Mao, Xuchao Ye, Hanpeng Li, Farman Ali, Yang Huang and Qiuming Zhu
Drones 2024, 8(5), 191; https://doi.org/10.3390/drones8050191 (registering DOI) - 11 May 2024
Abstract
With the fast development of unmanned aerial vehicles (UAVs), reliable UAV communication is becoming increasingly vital. The channel knowledge map (CKM) is a crucial bridge connecting the environment and the propagation channel that may visually depict channel characteristics. This paper presents a comprehensive [...] Read more.
With the fast development of unmanned aerial vehicles (UAVs), reliable UAV communication is becoming increasingly vital. The channel knowledge map (CKM) is a crucial bridge connecting the environment and the propagation channel that may visually depict channel characteristics. This paper presents a comprehensive scheme based on a UAV-assisted channel measurement system for constructing the CKM in real-world scenarios. Firstly, a three-dimensional (3D) CKM construction scheme for real-world scenarios is provided, which involves channel knowledge extraction, mapping, and completion. Secondly, an algorithm of channel knowledge extraction and completion is proposed. The sparse channel knowledge is extracted based on the sliding correlation and constant false alarm rate (CFAR) approaches. The 3D Kriging interpolation is used to complete the sparse channel knowledge. Finally, a UAV-assisted channel measurement system is developed and CKM measurement campaigns are conducted in campus and farmland scenarios. The path loss (PL) and root mean square delay spread (RMS-DS) are measured at different heights to determine CKMs. The measured and analyzed results show that the proposed construction scheme can effectively and accurately construct the CKMs in real-world scenarios. Full article
39 pages, 15198 KiB  
Review
Recent Advances in Manganese(III)-Assisted Radical Cyclization for the Synthesis of Natural Products: A Comprehensive Review
by Emre Biçer and Mehmet Yılmaz
Molecules 2024, 29(10), 2264; https://doi.org/10.3390/molecules29102264 (registering DOI) - 11 May 2024
Abstract
Natural products play an important part in synthetic chemistry since they have many pharmacological properties and are used as active drug compounds in pharmaceutical chemistry. However, synthesis of these complex molecules is difficult due to the requirement of various synthetic steps, which include [...] Read more.
Natural products play an important part in synthetic chemistry since they have many pharmacological properties and are used as active drug compounds in pharmaceutical chemistry. However, synthesis of these complex molecules is difficult due to the requirement of various synthetic steps, which include highly regio- and stereoselectivity. Therefore, oxidative radical cyclization assisted by manganese(III) acetate serves as an important step in obtaining spiro-, tricyclic, tetracyclic, and polycyclic derivatives of these compounds. Manganese(III)-based reactions offer a single-step regio- and stereoselective cyclizations and α-acetoxidations, reducing the number of synthetic steps. Also, the manganese(III)-mediated oxidative free radical cyclization method has been successfully applied for the synthesis of cyclic structures found in many natural products. This article presents a broad overview of manganese(III)-based radical reactions of natural products as a key step in overall synthesis. The authors have classified natural product synthesis processes assisted by manganese(III) acetate as intermolecular, intramolecular, oxidation, acetoxidation, aromatization, and polymerization reactions, respectively. Full article
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12 pages, 1641 KiB  
Article
The Development of a Sensitive Droplet Digital Polymerase Chain Reaction Test for Quantitative Detection of Goose Astrovirus
by Jianzhou Shi, Qianyue Jin, Xiaozhan Zhang, Jinbing Zhao, Na Li, Bingxue Dong, Jinran Yu and Lunguang Yao
Viruses 2024, 16(5), 765; https://doi.org/10.3390/v16050765 (registering DOI) - 11 May 2024
Abstract
(1) Goose astrovirus (GAstV) is a novel emerging pathogen that causes significant economic losses in waterfowl farming. A convenient, sensitive, and specific detection method for GAstV in field samples is important in order to effectively control GAstV. Droplet digital polymerase chain reaction (ddPCR) [...] Read more.
(1) Goose astrovirus (GAstV) is a novel emerging pathogen that causes significant economic losses in waterfowl farming. A convenient, sensitive, and specific detection method for GAstV in field samples is important in order to effectively control GAstV. Droplet digital polymerase chain reaction (ddPCR) is a novel, sensitive, good-precision, and absolute quantitation PCR technology which does not require calibration curves. (2) In this study, we developed a ddPCR system for the sensitive and accurate quantification of GAstV using the conserved region of the ORF2 gene. (3) The detection limit of ddPCR was 10 copies/µL, ~28 times greater sensitivity than quantitative real-time PCR (qPCR). The specificity of the test was determined by the failure of amplification of other avian viruses. Both ddPCR and qPCR tests showed good repeatability and linearity, and the established ddPCR method had high sensitivity and good specificity to GAstV. Clinical sample test results showed that the positive rate of ddPCR (88.89%) was higher than that of qPCR (58.33%). (4) As a result, our results suggest that the newly developed ddPCR method might offer improved analytical sensitivity and specificity in its GAstV measurements. The ddPCR could be widely applied in clinical tests for GAstV infections. Full article
(This article belongs to the Special Issue Viral Diseases of Livestock and Diagnostics)
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12 pages, 3863 KiB  
Article
Insights into the Origin of Activity Enhancement via Tuning Electronic Structure of Cu2O towards Electrocatalytic Ammonia Synthesis
by Meimei Kou, Ying Yuan, Ruili Zhao, Youkui Wang, Jiamin Zhao, Qing Yuan and Jinsheng Zhao
Molecules 2024, 29(10), 2261; https://doi.org/10.3390/molecules29102261 (registering DOI) - 11 May 2024
Abstract
The insight of the activity phase and reaction mechanism is vital for developing high-performance ammonia synthesis electrocatalysts. In this study, the origin of the electronic-dependent activity for the model Cu2O catalyst toward ammonia electrosynthesis with nitrate was probed. The modulation of [...] Read more.
The insight of the activity phase and reaction mechanism is vital for developing high-performance ammonia synthesis electrocatalysts. In this study, the origin of the electronic-dependent activity for the model Cu2O catalyst toward ammonia electrosynthesis with nitrate was probed. The modulation of the electronic state and oxygen vacancy content of Cu2O was realized by doping with halogen elements (Cl, Br, I). The electrocatalytic experiments showed that the activity of the ammonia production depends strongly on the electronic states in Cu2O. With increased electronic state defects in Cu2O, the ammonia synthesis performance increased first and then decreased. The Cu2O/Br with electronic defects in the middle showed the highest ammonia yield of 11.4 g h−1 g−1 at −1.0 V (vs. RHE), indicating that the pattern of change in optimal ammonia activity is consistent with the phenomenon of volcano curves in reaction chemistry. This work highlights a promising route for designing NO3RR to NH3 catalysts. Full article
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22 pages, 1952 KiB  
Review
The Role of Autophagy in Vascular Endothelial Cell Health and Physiology
by Meghan Hu, Joseph M. Ladowski and He Xu
Cells 2024, 13(10), 825; https://doi.org/10.3390/cells13100825 (registering DOI) - 11 May 2024
Abstract
Autophagy is a highly conserved cellular recycling process which enables eukaryotes to maintain both cellular and overall homeostasis through the catabolic breakdown of intracellular components or the selective degradation of damaged organelles. In recent years, the importance of autophagy in vascular endothelial cells [...] Read more.
Autophagy is a highly conserved cellular recycling process which enables eukaryotes to maintain both cellular and overall homeostasis through the catabolic breakdown of intracellular components or the selective degradation of damaged organelles. In recent years, the importance of autophagy in vascular endothelial cells (ECs) has been increasingly recognized, and numerous studies have linked the dysregulation of autophagy to the development of endothelial dysfunction and vascular disease. Here, we provide an overview of the molecular mechanisms underlying autophagy in ECs and our current understanding of the roles of autophagy in vascular biology and review the implications of dysregulated autophagy for vascular disease. Finally, we summarize the current state of the research on compounds to modulate autophagy in ECs and identify challenges for their translation into clinical use. Full article
(This article belongs to the Special Issue Autophagy and Inflammasome)
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12 pages, 2645 KiB  
Article
Dedicated Echoendoscope for Interventional Endoscopic Ultrasound: Comparison with a Conventional Echoendoscope
by Toshio Fujisawa, Shigeto Ishii, Yousuke Nakai, Hirofumi Kogure, Ko Tomishima, Yusuke Takasaki, Koichi Ito, Sho Takahashi, Akinori Suzuki and Hiroyuki Isayama
J. Clin. Med. 2024, 13(10), 2840; https://doi.org/10.3390/jcm13102840 (registering DOI) - 11 May 2024
Abstract
Interventional endoscopic ultrasound (I-EUS) is technically difficult and has risks of severe adverse events due to the scarcity of dedicated endoscopes and tools. A new EUS scope was developed for I-EUS and was modified to increase the puncture range, reduce the blind area, [...] Read more.
Interventional endoscopic ultrasound (I-EUS) is technically difficult and has risks of severe adverse events due to the scarcity of dedicated endoscopes and tools. A new EUS scope was developed for I-EUS and was modified to increase the puncture range, reduce the blind area, and overcome guidewire difficulties. We evaluated the usefulness and safety of a new EUS scope compared to a conventional EUS scope. Methods: All I-EUS procedures were performed at Juntendo University Hospital from April 2020 to April 2022. The primary outcomes included the procedure time and fluoroscopy time. The secondary outcomes included the technical success rate and the rates of procedure-related adverse events. Clinical data were retrospectively reviewed and statistically analyzed between the new and conventional EUS scopes. Results: In total, 143 procedures in 120 patients were analyzed. The procedure time was significantly shorter with the new EUS scope, but the fluoroscopy time was not different. Among the patients only undergoing EUS-guided biliary drainage (EUS-BD), 79 procedures in 74 patients were analyzed. Both the procedure time and fluoroscopy time were significantly shorter with the new EUS scope. Multivariate analysis revealed that a new EUS scope and use of covered metal stents could reduce the fluoroscopy time. The technical success rate and the adverse event rate were not significantly different between the total I-EUS and the EUS-BD only groups. However, the conventional scope showed stent deviation during stent placement, which did not happen with the new scope. Conclusions: The new EUS scope reduced procedure time for total I-EUS and fluoroscopy time for EUS-BD compared to a conventional EUS scope because of the improvement suitable for I-EUS. Full article
12 pages, 470 KiB  
Article
Fundamental Stability Skills: Reliability Analysis Using the Alfamov Assessment Tool
by Eva Santos-Miranda, Aida Carballo-Fazanes, Ezequiel Rey, Inés Piñeiro-García-Tuñón and Cristian Abelairas-Gómez
Children 2024, 11(5), 583; https://doi.org/10.3390/children11050583 (registering DOI) - 11 May 2024
Abstract
Fundamental movement skills (FMS), considered as building blocks of movement, have received growing interest due to their significant impact on both present and future health. FMS are categorized into locomotor, object control and stability skills. While there has been extensive research on assessing [...] Read more.
Fundamental movement skills (FMS), considered as building blocks of movement, have received growing interest due to their significant impact on both present and future health. FMS are categorized into locomotor, object control and stability skills. While there has been extensive research on assessing the proficiency and reliability of locomotor and object control skills, stability skills have received comparatively less attention. For this reason, this study aimed to assess the test–retest, intrarater and interrater reliability of five stability skills included in the Alfamov app. The performance of eighty-four healthy primary school children (60.8% girls), aged 6 to 12 years (mean ± standard deviation of 8.7 ± 1.8 years), in five stability skills was evaluated and scored by four raters, including two experts and two novices. The Alfamov tool, integrating various process-oriented tests, was used for the assessment. Reliability analyses were conducted through the computation of the intraclass correlation coefficient (ICC) along with the corresponding 95% confidence intervals. Good-to-excellent intrarater reliability, excellent interrater reliability and moderate-to-good reliability in the test–retest were achieved. The results proved that Alfamov is a robust test for evaluating stability skills and can be suitable for use by different professionals with less experience in assessing children’s motor competence. Full article
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41 pages, 2238 KiB  
Article
Unveiling University Groupings: A Clustering Analysis for Academic Rankings
by George Matlis, Nikos Dimokas and Petros Karvelis
Data 2024, 9(5), 67; https://doi.org/10.3390/data9050067 (registering DOI) - 11 May 2024
Abstract
The evaluation and ranking of educational institutions are of paramount importance to a wide range of stakeholders, including students, faculty members, funding organizations, and the institutions themselves. Traditional ranking systems, such as those provided by QS, ARWU, and THE, have offered valuable insights [...] Read more.
The evaluation and ranking of educational institutions are of paramount importance to a wide range of stakeholders, including students, faculty members, funding organizations, and the institutions themselves. Traditional ranking systems, such as those provided by QS, ARWU, and THE, have offered valuable insights into university performance by employing a variety of indicators to reflect institutional excellence across research, teaching, international outlook, and more. However, these linear rankings may not fully capture the multifaceted nature of university performance. This study introduces a novel clustering analysis that complements existing rankings by grouping universities with similar characteristics, providing a multidimensional perspective on global higher education landscapes. Utilizing a range of clustering algorithms—K-Means, GMM, Agglomerative, and Fuzzy C-Means—and incorporating both traditional and unique indicators, our approach seeks to highlight the commonalities and shared strengths within clusters of universities. This analysis does not aim to supplant existing ranking systems but to augment them by offering stakeholders an alternative lens through which to view and assess university performance. By focusing on group similarities rather than ordinal positions, our method encourages a more nuanced understanding of institutional excellence and facilitates peer learning among universities with similar profiles. While acknowledging the limitations inherent in any methodological approach, including the selection of indicators and clustering algorithms, this study underscores the value of complementary analyses in enriching our understanding of higher educational institutions’ performance. Full article
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13 pages, 269 KiB  
Article
Intrauterine Infusion and Hysteroscopic Injection of Autologous Platelet-Rich Plasma for Patients with a Persistent Thin Endometrium: A Prospective Case–Control Study
by Tzu-Ning Yu, Tsung-Hsien Lee, Maw-Sheng Lee, Yi-Chun Chen, Chung-I Chen, En-Hui Cheng, Pin-Yao Lin, Chun-Chia Huang and Chun-I Lee
J. Clin. Med. 2024, 13(10), 2838; https://doi.org/10.3390/jcm13102838 (registering DOI) - 11 May 2024
Abstract
To evaluate the effect of intrauterine infusion and hysteroscopic injection of autologous platelet-rich plasma (PRP) in patients with a persistent thin endometrium (EM) undergoing euploid frozen embryo transfer (EFET) cycles. Methods: This prospective case–control study enrolled 116 infertile women with thin EM [...] Read more.
To evaluate the effect of intrauterine infusion and hysteroscopic injection of autologous platelet-rich plasma (PRP) in patients with a persistent thin endometrium (EM) undergoing euploid frozen embryo transfer (EFET) cycles. Methods: This prospective case–control study enrolled 116 infertile women with thin EM (<7 mm) who underwent hormone replacement therapy (HRT) for EFET. These women had experienced at least one previous unsuccessful EFET cycle, which either resulted in the cancellation of the cycle or failure of pregnancy. A total of 55 women received an intrauterine infusion of PRP before FET, 38 received a hysteroscopic injection of PRP, and 23 received standard HRT treatment without PRP (control group). Only euploid embryos were transferred in these cycles. The primary outcomes were the implantation rate (IR) and clinical pregnancy rate (CPR) after EFET. Results: After receiving intrauterine infusion and hysteroscopic injection of PRP, 78.2% and 55.3% of patients, respectively, showed an EM thickness exceeding 7 mm, followed by embryo transfer. The hysteroscopic injection group demonstrated significantly higher IR (52%), a higher trend of CPR (52%), and a higher live birth rate (38%) than the control group (18%, 22%, and 4%). Conclusions: Intrauterine infusion and hysteroscopic injection of autologous PRP may be effective methods to increase EM thickness in HRT cycles. According to our results, both methods could increase EM thickness, while hysteroscopic injection appeared to provide more significant assistance in increasing IR, CPR, and live birth rate after EFET in patients with persistent thin EM. Full article
(This article belongs to the Special Issue Assisted Reproductive Technology: Clinical Advances and Challenges)
11 pages, 3602 KiB  
Article
Enhanced Catalytic Hydrogenation of Olefins in Sulfur-Rich Naphtha Using Molybdenum Carbide Supported on γ-Al2O3 Spheres under Steam Conditions: Simulating the Hot Separator Stream Process
by Hadj Abbas Abbas, Zahra Asgar Pour, Mohammed S. Alnafisah, Pablo Gonzalez Cortes, Mustapha El Hariri El Nokab, Ahmed Elshewy and Khaled O. Sebakhy
Materials 2024, 17(10), 2278; https://doi.org/10.3390/ma17102278 (registering DOI) - 11 May 2024
Abstract
Spheres comprising 10 wt.% Mo2C/γ-Al2O3, synthesized through the sucrose route, exhibited unprecedented catalytic activity for olefin hydrogenation within an industrial naphtha feedstock that contained 23 wt.% olefins, as determined by supercritical fluid chromatography (SFC). The catalyst demonstrated [...] Read more.
Spheres comprising 10 wt.% Mo2C/γ-Al2O3, synthesized through the sucrose route, exhibited unprecedented catalytic activity for olefin hydrogenation within an industrial naphtha feedstock that contained 23 wt.% olefins, as determined by supercritical fluid chromatography (SFC). The catalyst demonstrated resilience to sulfur, exhibiting no discernible deactivation signs over a tested 96 h operational period. The resultant hydrogenated naphtha from the catalytic process contained only 2.5 wt.% olefins when the reaction was conducted at 280 °C and 3.44 × 106 Pa H2, subsequently blended with Athabasca bitumen to meet pipeline specifications for oil transportation. Additionally, the carbide catalyst spheres effectively hydrogenated olefins under steam conditions without experiencing any notable hydrogenation in the aromatics. We propose the supported carbide catalyst as a viable alternative to noble metals, serving as a selective agent for olefin elimination from light petroleum distillates in the presence of steam and sulfur, mitigating the formation of gums and deposits during the transportation of diluted bitumen (dilbit) through pipelines. Full article
(This article belongs to the Special Issue Design and Applications of Functional Materials, Volume II)
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18 pages, 646 KiB  
Review
Untangling Structural and Functional Diversity of Prokaryotic Microbial Assemblage on Mangrove Pneumatophores
by Varsha Bohra, Nora Fung-Yee Tam, Luzhen Chen, Kaze King-Yip Lai, Winnie Lam, Steven Jing-Liang Xu, Hai-Chao Zhou, Tao Lang, Chak-Lam Lee and Fred Wang-Fat Lee
J. Mar. Sci. Eng. 2024, 12(5), 802; https://doi.org/10.3390/jmse12050802 (registering DOI) - 11 May 2024
Abstract
Mangroves are important coastal wetlands along tropical and subtropical regions. Pneumatophore, a kind of aerial root, is among the prominent components of a mangrove ecosystem, which provides microhabitats for a range of prokaryotic (bacteria and cyanobacteria) microbial assemblages, whose role in the maintenance [...] Read more.
Mangroves are important coastal wetlands along tropical and subtropical regions. Pneumatophore, a kind of aerial root, is among the prominent components of a mangrove ecosystem, which provides microhabitats for a range of prokaryotic (bacteria and cyanobacteria) microbial assemblages, whose role in the maintenance of mangrove ecology often remains neglected. Very few studies are available on pneumatophore-associated prokaryotic microorganisms (PAPMs). The majority of them are related to the microscopic identification of cyanobacteria, with very limited research on the bacterial population, even though they demand more attention. Also, very scarce information is available on biotic and abiotic factors shaping the PAPMs. The objective of this review is to highlight the structural and functional importance of prokaryotic organisms associated with pneumatophores. This review begins with a brief introduction of what mangrove pneumatophores are, then focuses on the PAPMs, accentuating the breadth and depth of information gained from previous research. We further discuss how a combination of a traditional cultivable approach and a newly developed omics approach can be efficaciously employed to untangle PAPMs. This review provides updated information on PAPMs, which will intensify the visibility and necessity of pneumatophore-associated microbial community research. Full article
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18 pages, 2942 KiB  
Review
The Functional Roles of the Src Homology 2 Domain-Containing Inositol 5-Phosphatases SHIP1 and SHIP2 in the Pathogenesis of Human Diseases
by Spike Murphy Müller and Manfred Jücker
Int. J. Mol. Sci. 2024, 25(10), 5254; https://doi.org/10.3390/ijms25105254 (registering DOI) - 11 May 2024
Abstract
The src homology 2 domain-containing inositol 5-phosphatases SHIP1 and SHIP2 are two proteins involved in intracellular signaling pathways and have been linked to the pathogenesis of several diseases. Both protein paralogs are well known for their involvement in the formation of various kinds [...] Read more.
The src homology 2 domain-containing inositol 5-phosphatases SHIP1 and SHIP2 are two proteins involved in intracellular signaling pathways and have been linked to the pathogenesis of several diseases. Both protein paralogs are well known for their involvement in the formation of various kinds of cancer. SHIP1, which is expressed predominantly in hematopoietic cells, has been implicated as a tumor suppressor in leukemogenesis especially in myeloid leukemia, whereas SHIP2, which is expressed ubiquitously, has been implicated as an oncogene in a wider variety of cancer types and is suggested to be involved in the process of metastasis of carcinoma cells. However, there are numerous other diseases, such as inflammatory diseases as well as allergic responses, Alzheimer’s disease, and stroke, in which SHIP1 can play a role. Moreover, SHIP2 overexpression was shown to correlate with opsismodysplasia and Alzheimer’s disease, as well as metabolic diseases. The SHIP1-inhibitor 3-α-aminocholestane (3AC), and SHIP1-activators, such as AQX-435 and AQX-1125, and SHIP2-inhibitors, such as K161 and AS1949490, have been developed and partly tested in clinical trials, which indicates the importance of the SHIP-paralogs as possible targets in the therapy of those diseases. The aim of this article is to provide an overview of the current knowledge about the involvement of SHIP proteins in the pathogenesis of cancer and other human diseases and to create awareness that SHIP1 and SHIP2 are more than just tumor suppressors and oncogenes. Full article
(This article belongs to the Special Issue Latest Review Papers in Molecular Immunology 2024)
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13 pages, 992 KiB  
Article
Racial Disparities in Cardiovascular and Cerebrovascular Adverse Events in Patients with Non-Hodgkin Lymphoma: A Nationwide Analysis
by Kanishka Uttam Chandani, Siddharth Pravin Agrawal, Maharshi Raval, Sajid Siddiq, Ahmed Nadeem, Ashish V. Chintakuntlawar and Shahrukh K. Hashmi
Medicina 2024, 60(5), 800; https://doi.org/10.3390/medicina60050800 (registering DOI) - 11 May 2024
Abstract
Background and Objectives: Non-Hodgkin lymphoma (NHL) has the sixth-highest malignancy-related mortality in the United States (US). However, inequalities exist in access to advanced care in specific patient populations. We aim to study the racial disparities in major adverse cardiovascular and cerebrovascular events [...] Read more.
Background and Objectives: Non-Hodgkin lymphoma (NHL) has the sixth-highest malignancy-related mortality in the United States (US). However, inequalities exist in access to advanced care in specific patient populations. We aim to study the racial disparities in major adverse cardiovascular and cerebrovascular events (MACCEs) in NHL patients. Materials and Methods: Using ICD-10 codes, patients with NHL were identified from the US National Inpatient Sample 2016–2019 database. Baseline characteristics, comorbidities, and MACCE outcomes were studied, and results were stratified based on the patient’s race. Results: Of the 777,740 patients with a diagnosis of NHL, 74.22% (577,215) were White, 9.15% (71,180) were Black, 9.39% (73,000) were Hispanic, 3.33% (25,935) were Asian/Pacific Islander, 0.36% (2855) were Native American, and 3.54% (27,555) belonged to other races. When compared to White patients, all-cause mortality (ACM) was significantly higher in Black patients (aOR 1.27, 95% CI 1.17–1.38, p < 0.001) and in Asian/Pacific Islander patients (aOR 1.27, 95% CI 1.12–1.45, p < 0.001). Sudden cardiac death was found to have a higher aOR in all racial sub-groups as compared to White patients; however, it was statistically significant in Black patients only (aOR 1.81, 95% CI 1.52–2.16, p < 0.001). Atrial fibrillation (AF) risk was significantly lower in patients who were Black, Hispanic, and of other races compared to White patients. Acute myocardial infarction (AMI) was noted to have a statistically significantly lower aOR in Black patients (0.70, 95% CI 0.60–0.81, p < 0.001), Hispanic patients (0.69, 95% CI 0.59–0.80, p < 0.001), and patients of other races (0.57, 95% CI 0.43–0.75, p < 0.001) as compared to White patients. Conclusions: Racial disparities are found in MACCEs among NHL patients, which is likely multifactorial, highlighting the need for healthcare strategies stratified by race to mitigate the increased risk of MACCEs. Further research involving possible epigenomic influences and social determinants of health contributing to poorer outcomes in Black and Asian/Pacific Islander patients with NHL is imperative. Full article
(This article belongs to the Section Neurology)
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26 pages, 3432 KiB  
Article
Adaptability and Interconnectedness in Latin American Innerburbs: An Assessment of the Public/Private Interface in Informal Settlements
by Carlos Augusto Martínez Muñoz and Francisco Javier Maroto Ramos
Buildings 2024, 14(5), 1378; https://doi.org/10.3390/buildings14051378 (registering DOI) - 11 May 2024
Abstract
An “Innerburb” is an urban structure that emerged between the 1950s and 1980s, settled in rural areas, and is considered the first periphery of the Latin American city. This structure results from socio-spatial and territorial evolutionary processes, constituting the pinnacle of informal evolution. [...] Read more.
An “Innerburb” is an urban structure that emerged between the 1950s and 1980s, settled in rural areas, and is considered the first periphery of the Latin American city. This structure results from socio-spatial and territorial evolutionary processes, constituting the pinnacle of informal evolution. However, despite offering a comprehensive perspective on the informal problem, innerburbs have been scarcely reviewed in the literature. This article explores the Latin American innerburb by adopting as a method a comparative study of the public/private interface in the cases of San Cosme in Lima, Villa Rodolfo Ricciardelli in Buenos Aires and Vila Heliopolis in São Paulo, evaluating their adaptation and interconnection with the city through morphological indicators, using morphological mapping through satellite images as an analytical tool, and using Space Syntax as a topological approach in the analysis of connectivity and visibility indicators. The objective of the research is the detection of morphological patterns that alter the functioning of the public/private interface in innerburbs. The results show that the existence of impermeable facades, the lack of public spaces and the illegal appropriation in the development of informal practices are transgressive adaptability patterns at the micro-scale that affect the interface, drastically limiting the interconnection between the innerburb and the formal fabric, restricting its morphological openness and affecting the development of socioeconomic activities. As a discussion and conclusion, corrective measures for progressive improvement in innerburbs are established, focusing on the adaptability of housing and road space as a means of interconnection between the innerburb and the city. Full article
(This article belongs to the Special Issue Advanced Studies in Urban and Regional Planning)
12 pages, 1926 KiB  
Article
Dual-Message QR Codes
by Kuo-Chien Chou and Ran-Zan Wang
Sensors 2024, 24(10), 3055; https://doi.org/10.3390/s24103055 (registering DOI) - 11 May 2024
Abstract
A novel dual-message QR code is proposed for carrying two individual messages that can be read by standard QR code readers: one from a close range and the other from a large distance. By exploring the module value determining the rule of typical [...] Read more.
A novel dual-message QR code is proposed for carrying two individual messages that can be read by standard QR code readers: one from a close range and the other from a large distance. By exploring the module value determining the rule of typical QR code readers, we designed two-state module blocks that can be recognized as different module values through changing the distance from which the QR code is scanned, and applied them to construct the proposed dual-message QR code. Experiments were conducted to test the readability of the two messages within a dual-message QR code, with the results demonstrating the high feasibility of the proposed method. The dual-message QR code can be applied for designing creative applications. For example, an interactive wedding card that can access the growing film of the groom and that of the bride interchangeably, which bring the viewers a higher-quality experience. Full article
(This article belongs to the Special Issue Data Engineering in the Internet of Things—Second Edition)

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