The 2023 MDPI Annual Report has
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10 pages, 1115 KiB  
Article
The Precision and Safety of Ultrasound-Guided versus Palpation-Guided Needle Placement on the Plantar Fascia and Flexor Digitorum Brevis Interface: An Anatomical Study
by Miguel Malo-Urriés, Sergio Borrella-Andrés, Carlos López-de-Celis, César Fernández-de-las-Peñas, Albert Pérez-Bellmunt, José L. Arias-Buría, Isabel Albarova-Corral and Jacobo Rodríguez-Sanz
Healthcare 2024, 12(10), 1000; https://doi.org/10.3390/healthcare12101000 (registering DOI) - 13 May 2024
Abstract
Background: Evidence suggests the plantar fascia and its interphase with the flexor digitorum brevis muscle can play a relevant role in plantar heel pain. Needling interventions could offer an appropriate treatment strategy to addressing this interface. Objective: We compared the accuracy and safety [...] Read more.
Background: Evidence suggests the plantar fascia and its interphase with the flexor digitorum brevis muscle can play a relevant role in plantar heel pain. Needling interventions could offer an appropriate treatment strategy to addressing this interface. Objective: We compared the accuracy and safety of ultrasound-guided versus palpation-guided procedures for the proper targeting of the interface between the plantar fascia and the flexor digitorum brevis with a solid needle. Methods: A crossover cadaveric study was conducted. Five experienced therapists performed a series of 20 needle insertions each (n = 100 in total, 10 landmark-guided and 10 ultrasound-guided) on 10 anatomical samples. The therapists were instructed to accurately place the needle on the interface between the plantar fascia and the flexor digitorum brevis muscle. The distance of the tip of the needle to the identified target (accuracy), the surrounding sensitive structures targeted (safety), the time needed for the procedure, the number of needle passes, and the needle length outside the skin were assessed. Results: The ultrasound-guided technique was associated with a significantly higher accuracy (p < 0.001) but without differences in safety (p = 0.249) as compared to the palpation-guided procedure. Conclusion: Our results suggest that ultrasound-guided insertion exhibits greater accuracy but not greater safety than palpation-guided insertion when targeting the interface between the plantar fascia and the flexor digitorum brevis. Full article
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13 pages, 245 KiB  
Article
Evaluating the Efficacy of a Peripheral Nerve Simulator-Guided Brachial Plexus Block in Rabbits Undergoing Orthopaedic Surgery Compared to Systemic Analgesia
by Sophie A. Mead, Matthew J. Allen, Sara Ahmed Hassouna Elsayed and Claudia S. Gittel
Vet. Sci. 2024, 11(5), 213; https://doi.org/10.3390/vetsci11050213 (registering DOI) - 13 May 2024
Abstract
Locoregional anaesthetic techniques are invaluable for providing multimodal analgesia for painful surgical procedures. This prospective, randomised study describes a nerve stimulator-guided brachial plexus blockade (BPB) in rabbits undergoing orthopaedic surgery in comparison to systemic lidocaine. Premedication was provided with intramuscular (IM) medetomidine, fentanyl, [...] Read more.
Locoregional anaesthetic techniques are invaluable for providing multimodal analgesia for painful surgical procedures. This prospective, randomised study describes a nerve stimulator-guided brachial plexus blockade (BPB) in rabbits undergoing orthopaedic surgery in comparison to systemic lidocaine. Premedication was provided with intramuscular (IM) medetomidine, fentanyl, and midazolam. Anaesthesia was induced (propofol IV) and maintained with isoflurane. Nine rabbits received a lidocaine BPB (2%; 0.3 mL kg−1), and eight received a lidocaine constant rate infusion (CRI) (2 mg kg−1 IV, followed by 100 µg kg−1 min−1). Rescue analgesia was provided with fentanyl IV. Carprofen was administered at the end of the surgery. Postoperative pain was determined using the Rabbit Grimace Scale (RGS) and a composite pain scale. Buprenorphine was administered according to the pain score for two hours after extubation. Rabbits were filmed during the first two hours to measure distance travelled and behaviours. Food intake and faeces output were compared. Every rabbit in CRI required intraoperative rescue analgesia compared to none in BPB. However, rabbits in both groups had similar pain scores, and there was no difference in the administration of postoperative analgesia. There were no significant differences in food intake or faeces production over 18 h, and no significant differences in distance travelled or behaviours examined during the first two hours. BPB seems superior for intraoperative analgesia. Postoperatively, both groups were comparable. Full article
(This article belongs to the Special Issue Anesthesia and Pain Management in Veterinary Surgery)
20 pages, 8379 KiB  
Article
Insights into the PYR/PYL/RCAR Gene Family in Pomegranates (Punica granatum L.): A Genome-Wide Study on Identification, Evolution, and Expression Analysis
by Ke Yin, Fan Cheng, Hongfang Ren, Jingyi Huang, Xueqing Zhao and Zhaohe Yuan
Horticulturae 2024, 10(5), 502; https://doi.org/10.3390/horticulturae10050502 (registering DOI) - 13 May 2024
Abstract
The response of plants to abiotic stress is intricately mediated by PYR/PYL/RCARs, key components within the ABA signal transduction pathway. Despite the widespread identification of PYL genes across diverse plant species, the evolutionary history and structural characteristics of these genes within the [...] Read more.
The response of plants to abiotic stress is intricately mediated by PYR/PYL/RCARs, key components within the ABA signal transduction pathway. Despite the widespread identification of PYL genes across diverse plant species, the evolutionary history and structural characteristics of these genes within the pomegranate (Punica granatum L.) remained unexplored. In this study, we uncovered, for the first time, 12 PgPYLs from the whole genome dataset of ‘Tunisia’, mapping them onto five chromosomes and categorizing them into three distinct subgroups (Group I, Group II, and Group III) through phylogenetic analysis. Detailed examination of the composition of these genes revealed similar conserved motifs and exon–intron structures among genes within the same subgroup. Fragment duplication emerged as the primary mechanism driving the amplification of the PYL gene family, as evidenced by intra-species collinearity analysis. Furthermore, inter-species collinearity analysis provided insights into potential evolutionary relationships among the identified PgPYL genes. Cis-acting element analysis revealed a rich repertoire of stress and hormone response elements within the promoter region of PgPYLs, emphasizing their putative roles in diverse signaling pathways. Upon treatment with 100 μmol/L ABA, we investigated the expression patterns of the PgPYL gene family, and the qRT-PCR data indicated a significant up-regulation in the majority of PYL genes. This suggested an active involvement of PgPYL genes in the plant’s response to exogenous ABA. Among them, PgPYL1 was chosen as a candidate gene to explore the function of the gene family, and the CDS sequence of PgPYL1 was cloned from pomegranate leaves with a full length of 657 bp, encoding 218 amino acids. Tobacco transient expression analysis demonstrated a consistent trend in the expression levels of pBI121-PgPYL1 and the related genes of the ABA signaling pathway, both of which increased initially before declining. This study not only contributes to the elucidation of the genomic and structural attributes of PgPYL genes but also provides a foundation for understanding their potential functions in stress responses. The identified conserved motifs, evolutionary relationships, and expression patterns under ABA treatment pave the way for further research into the PgPYL gene family’s role in pomegranate biology, offering valuable insights for future studies on genetic improvement and stress resilience in pomegranate cultivation. Full article
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14 pages, 6427 KiB  
Review
Unraveling TAFRO Syndrome: An In-Depth Look at the Pathophysiology, Management, and Future Perspectives
by Juan Carlos Caballero, Nazaret Conejero, Laura Solan, Francisco Javier Diaz de la Pinta, Raul Cordoba and Alberto Lopez-Garcia
Biomedicines 2024, 12(5), 1076; https://doi.org/10.3390/biomedicines12051076 (registering DOI) - 13 May 2024
Abstract
TAFRO syndrome is a rare and aggressive inflammatory entity characterized by thrombocytopenia, anasarca, fever, renal failure, reticulin fibrosis, and organomegaly. This entity supposes a diagnostic and therapeutic challenge due to its significant overlap with Castleman’s disease. However, distinct clinical and histological features warrant [...] Read more.
TAFRO syndrome is a rare and aggressive inflammatory entity characterized by thrombocytopenia, anasarca, fever, renal failure, reticulin fibrosis, and organomegaly. This entity supposes a diagnostic and therapeutic challenge due to its significant overlap with Castleman’s disease. However, distinct clinical and histological features warrant its classification as a separate subtype of idiopathic multicentric Castleman’s disease (iMCD). While recent modifications have been made to the diagnostic criteria for iMCD, these criteria lack specificity for this particular condition, further complicating diagnosis. Due to its inflammatory nature, several complex molecular signaling pathways are involved, including the JAK-STAT pathway, NF-kB, and signal amplifiers such as IL-6 and VEGF. Understanding the involvement of immune dysfunction, some infectious agents, genetic mutations, and specific molecular and signaling pathways could improve the knowledge and management of the condition, leading to effective treatment strategies. The current therapeutic approaches include corticosteroids, anti-IL6 drugs, rituximab, and chemotherapy, among others, but response rates vary, highlighting the need for personalized strategies. The prognosis is uncertain due to diagnostic difficulties, emphasizing the importance of early intervention and appropriate targeted treatment. This comprehensive review examines the evolving landscape of TAFRO syndrome, including the pathophysiology, diagnostic criteria, treatment strategies, prognosis, and future perspectives. Full article
(This article belongs to the Special Issue Diagnosis, Pathogenesis and Treatment of TAFRO Syndrome)
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23 pages, 7857 KiB  
Article
Second-Life Electric Vehicle Batteries for Home Photovoltaic Systems: Transforming Energy Storage and Sustainability
by Md. Tanjil Sarker, Mohammed Hussein Saleh Mohammed Haram, Siow Jat Shern, Gobbi Ramasamy and Fahmid Al Farid
Energies 2024, 17(10), 2345; https://doi.org/10.3390/en17102345 (registering DOI) - 13 May 2024
Abstract
Solar-based home PV systems are the most amazing eco-friendly energy innovations in the world, which are not only climate-friendly but also cost-effective solutions. The tropical environment of Malaysia makes it difficult to adopt photovoltaic (PV) systems because of the protracted rainy monsoon season, [...] Read more.
Solar-based home PV systems are the most amazing eco-friendly energy innovations in the world, which are not only climate-friendly but also cost-effective solutions. The tropical environment of Malaysia makes it difficult to adopt photovoltaic (PV) systems because of the protracted rainy monsoon season, which makes PV systems useless without backup batteries. Large quantities of lithium-ion battery (LIB) trash are being produced by the electric vehicle (EV) sector. A total of 75% of the highest capacity levels have been discarded. By 2035, it is predicted that the wasted LIBs held as a result of expensive recycling and difficult material separation would carry up to 1200 GWh. An economical and sustainable option is offered by our study, which prototypes a replicated LIB pack that is incorporated into a PV home system. This study investigates the transformational power of second-life electric vehicle batteries (SLEVBs) when incorporated into home photovoltaic (PV) systems. The concept entails reusing existing electric vehicle batteries for stationary applications, offering a unique approach to extending the life of these batteries while meeting the growing need for sustainable domestic energy storage. The study looks at the technological feasibility, economic viability, and environmental effect of introducing SLEVBs into household PV systems, giving vital insight into their role in revolutionizing energy storage techniques and promoting sustainability. In comparison to the Lead–Acid Battery (LAB) system, the SLEVB system has a cheaper total cost of ownership, with savings of 12.62% compared with new LABs. A CO2 emission reduction of at least 20% is achieved by using the SLEVB system compared with LABs. Electricity can be provided in houses in rural areas where there is no electricity. As a result, the security and superiority of the life of rural residents will improve. It is anticipated that the suggested strategy will lower EV pricing, enabling EV adoption for M40 and B40 groups. Consequently, the Malaysian and worldwide EV business will remain viable. Full article
(This article belongs to the Section D2: Electrochem: Batteries, Fuel Cells, Capacitors)
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20 pages, 3360 KiB  
Review
A Review of the Rumen Microbiota and the Different Molecular Techniques Used to Identify Microorganisms Found in the Rumen Fluid of Ruminants
by Éder Bruno Rebelo da Silva, Jamile Andréa Rodrigues da Silva, Welligton Conceição da Silva, Tatiane Silva Belo, Carlos Eduardo Lima Sousa, Maria Roseane Pereira dos Santos, Kedson Alessandri Lobo Neves, Thomaz Cyro Guimarães de Carvalho Rodrigues, Raimundo Nonato Colares Camargo-Júnior and José de Brito Lourenço-Júnior
Animals 2024, 14(10), 1448; https://doi.org/10.3390/ani14101448 (registering DOI) - 13 May 2024
Abstract
Variations in environments, including climate, diet, and agricultural practices, significantly impact the composition and microbial activity. A profound understanding of these adaptations allows for the improvement of nutrition and ruminant production. Therefore, this review aims to compile data from the literature on the [...] Read more.
Variations in environments, including climate, diet, and agricultural practices, significantly impact the composition and microbial activity. A profound understanding of these adaptations allows for the improvement of nutrition and ruminant production. Therefore, this review aims to compile data from the literature on the rumen microbiota and molecular techniques for identifying the different types of microorganisms from the rumen fluid of ruminants. Analyzing the literature on rumen microbiology in different ruminants is complex due to microbial interactions, influenced by the environment and nutrition of these animals. In addition, it is worth noting that the genera of protozoa and fungi most evident in the studies used in this review on the microbiology of rumen fluid were Entodinium spp. and Aspergillus spp., respectively, and Fibrobacter spp. for bacteria. About the techniques used, it can be seen that DNA extraction, amplification, and sequencing were the most cited in the studies evaluated. Therefore, this review describes what is present in the literature and provides an overview of the main microbial agents in the rumen and the molecular techniques used. Full article
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16 pages, 2887 KiB  
Article
A Practical Method for Synthesizing Iptacopan
by Zhiwei Tang, Shaojie Chu, Xuesong Wu, Shaoxin Chen, Likuo Chen, Jiawei Tang and Hongbo Wang
Molecules 2024, 29(10), 2289; https://doi.org/10.3390/molecules29102289 (registering DOI) - 13 May 2024
Abstract
Iptacopan, the first orally available small-molecule complement factor B inhibitor, was developed by Novartis AG of Switzerland. Iptacopan for the treatment of PNH was just approved by the FDA in December 2023. Other indications for treatment are still in phase III clinical trials. [...] Read more.
Iptacopan, the first orally available small-molecule complement factor B inhibitor, was developed by Novartis AG of Switzerland. Iptacopan for the treatment of PNH was just approved by the FDA in December 2023. Other indications for treatment are still in phase III clinical trials. Iptacopan is a small-molecule inhibitor targeting complement factor B, showing positive therapeutic effects in the treatment of PNH, C3 glomerulonephritis, and other diseases. Although Iptacopan is already on the market, there has been no detailed synthesis process or specific parameter report on the intermediates during the synthesis of its compounds except for the original research patent. In this study, a practical synthesis route for Iptacopan was obtained through incremental improvement while a biosynthesis method for ketoreductase was used for the synthesis of the pivotal intermediate 12. Moreover, by screening the existing enzyme library of our research group on the basis of random as well as site-directed mutagenesis methods, an enzyme (M8) proven to be of high optical purity with a high yield for biocatalectic reduction was obtained. This enzyme was used to prepare the compound benzyl (2S,4S)-4-hydroxy-2-(4-(methoxycarbonyl)-phenyl)-piperidine-1-carboxylate) white powder (36.8 g HPLC purity: 98%, ee value: 99%). In the synthesis of intermediate 15, the reaction was improved from two-step to one-step, which indicated that the risk of chiral allosterism was reduced while the scale was expanded. Finally, Iptacopan was synthesized in a seven-step reaction with a total yield of 29%. Since three chiral intermediate impurities were synthesized directionally, this paper lays a solid foundation for the future of pharmaceutical manufacturing. Full article
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18 pages, 836 KiB  
Article
Supporting Sustainable and User-Oriented Educational Technology Innovation with the University Innovation Canvas
by Mia Bangerl, Sebastian Dennerlein, Katharina Maitz, Marie Nitschke, Martin Ebner and Viktoria Pammer-Schindler
Educ. Sci. 2024, 14(5), 528; https://doi.org/10.3390/educsci14050528 (registering DOI) - 13 May 2024
Abstract
Innovating higher education teaching and learning is challenging due to structural, cultural, and resource-related reasons, and research indicates that university innovation benefits from a bottom-up approach as well as strategic alignment with university objectives. In this paper, we investigate such bottom-up innovation processes [...] Read more.
Innovating higher education teaching and learning is challenging due to structural, cultural, and resource-related reasons, and research indicates that university innovation benefits from a bottom-up approach as well as strategic alignment with university objectives. In this paper, we investigate such bottom-up innovation processes within higher education as supported by a specific tool: the University Innovation Canvas (UIC). Adapted from the Business Model Canvas and Lean Canvas, the UIC is designed to promote educational technology innovation and foster alignment of the innovation process with strategic objectives of the university: namely, sustainability and user orientation. An evaluation of the UIC based on interview and questionnaire data shows that its usage differs between innovation teams (on paper vs. digital, individual vs. collaborative, co-located vs. remotely, and synchronous vs. asynchronous). UIC usability is linked with these differences and with teams’ experience in realizing innovations. Overall, the UIC is perceived to be useful by (particularly, less-experienced) innovation teams and is successful at supporting sustainable and user-oriented innovations, as 14/15 innovations are still in use after up to four years since completion. To maximize its potential, more effort needs to be devoted to improving understanding of the UIC and supporting different workflows of innovation teams in the future. Full article
(This article belongs to the Special Issue Digital Learning Innovation)
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14 pages, 7654 KiB  
Article
Diffusion Bonding of Al2O3 Dispersion-Strengthened 316L Composite by Gleeble 3800
by Tétény Baross, Haroune Ben Zine Rachid, Péter Bereczki, Miklós Palánkai, Katalin Balázsi, Csaba Balázsi and Gábor Veres
Materials 2024, 17(10), 2300; https://doi.org/10.3390/ma17102300 (registering DOI) - 13 May 2024
Abstract
The aim of this work is to investigate the bonding properties of the ceramic dispersion-strengthened 316L (CDS-316L) composites with the reference 316L stainless steel (REF-316L) using a Gleeble 3800 physical simulator. In previous works, two different composites, REF-316L and 316L, with 1 wt% [...] Read more.
The aim of this work is to investigate the bonding properties of the ceramic dispersion-strengthened 316L (CDS-316L) composites with the reference 316L stainless steel (REF-316L) using a Gleeble 3800 physical simulator. In previous works, two different composites, REF-316L and 316L, with 1 wt% Al2O3 composite (CDS-316L) have been prepared by spark plasma sintering (SPS). In the present work, these specimens were diffusion-bonded using the following parameters: a temperature range of 950–1000 °C and a uniaxial pressure of 20–30 MPa. It was observed that the deformation of the CDS-316L during the uniaxial bonding process was higher compared to the 316L steel rods. The addition of alumina particles increased the micro-hardness of the 316L steel. The samples were broken in the CDS-316L zones, not at the diffusion-bonded interfaces. No diffusion zones have been observed within the investigated magnification for all composites, where the interfaces between the different specimens were well defined. Full article
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25 pages, 10767 KiB  
Article
A Sand Boil Database for Piping Risk Management in the Po River, Italy
by Laura Tonni, Michela Marchi, Agnese Bassi and Alessandro Rosso
Water 2024, 16(10), 1384; https://doi.org/10.3390/w16101384 (registering DOI) - 13 May 2024
Abstract
Sand boil formation at the toe of river embankments is the typical manifestation of the initiation and progression of an internal erosion process known as backward erosion piping, which is recognized to be a major concern in many river systems worldwide. In Italy, [...] Read more.
Sand boil formation at the toe of river embankments is the typical manifestation of the initiation and progression of an internal erosion process known as backward erosion piping, which is recognized to be a major concern in many river systems worldwide. In Italy, more than 130 sand boils have been detected along the Po River, many of them experiencing recurrent reactivations during high-water events. In recent years, as part of the activities of the European project LIFE SandBoil, the Italian authority responsible for flood protection and flood damage reduction along the Po River has implemented a GIS-based web application to catalogue the sand boils observed in its operating area. The resulting database allows keeping records of a comprehensive and varied set of information, in terms of predisposing factors, initiation conditions and surface effects. Taking as a reference a well-documented cross-section of the Po River prone to piping, this paper describes the main features of this versatile and flexible tool, whose long-term aim is to support vulnerability studies and the development of risk maps against piping. The database, which might also accommodate data from different river basins, is thus meant to help in flood risk management, by suggesting priorities for the implementation of mitigation measures and allowing the monitoring of intervention effectiveness. Full article
(This article belongs to the Section Water Erosion and Sediment Transport)
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16 pages, 2171 KiB  
Article
Winter Hive Debris Analysis Is Significant for Assessing the Health Status of Honeybee Colonies (Apis mellifera)
by Ivana Tlak Gajger, Klara Bakarić, Ivan Toplak, Laura Šimenc, Urška Zajc and Metka Pislak Ocepek
Insects 2024, 15(5), 350; https://doi.org/10.3390/insects15050350 (registering DOI) - 13 May 2024
Abstract
Honeybee diseases are one of the most significant and most common causes of honeybee colonies’ weakness and death. An early diagnosis of subclinical infections is necessary to implement precautionary and control measures. Sampling debris from hive bottom boards is simple, non-invasive, and cheap. [...] Read more.
Honeybee diseases are one of the most significant and most common causes of honeybee colonies’ weakness and death. An early diagnosis of subclinical infections is necessary to implement precautionary and control measures. Sampling debris from hive bottom boards is simple, non-invasive, and cheap. In this study, we collected winter debris samples in apiaries located in the continental part of Croatia. We used molecular methods, PCR and qPCR, for the first time to analyze those samples. Laboratory results were compared with the health condition and strength of honeybee colonies at an apiary in spring. Our study successfully identified the presence and quantity of various pathogens, including the presence of Vairimorpha spp. (Nosema spp.), quintefied Paenibacillus larvae, Acute Bee Paralysis Virus (ABPV), Black Queen Cell Virus (BQCV), Deformed Wing Virus (DWV), and Sacbrood Virus (SBV). However, our analysis did not detect Melissococcus plutonius, Crithidia mellificae, Lotmaria passim, and Aethina tumida. Samples of winter debris were also examined for the presence and quantification of the V. destructor mites, and their natural mite fall was observed in spring. Honeybee colonies were simultaneously infected by an average of four to six pathogens. Some observed honeybee colonies developed characteristic symptoms, while others did not survive the winter. Full article
(This article belongs to the Section Insect Societies and Sociality)
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19 pages, 20244 KiB  
Article
Estimation of Land Deformation and Groundwater Storage Dynamics in Shijiazhuang–Baoding–Cangzhou–Hengshui Using Multi-Temporal Interferometric Synthetic Aperture Radar
by Qiuhong Yang, Xing Zhang, Jun Hu, Rong Gui and Liuming Yang
Remote Sens. 2024, 16(10), 1724; https://doi.org/10.3390/rs16101724 (registering DOI) - 13 May 2024
Abstract
Groundwater resources are crucial to socio-economic development and the ecosystem, and over-extraction can cause the groundwater level to drop, deplete reserves, and trigger geological hazards like land subsidence. The North China Plain (NCP) has experienced both subsidence and groundwater depletion due to over-extraction [...] Read more.
Groundwater resources are crucial to socio-economic development and the ecosystem, and over-extraction can cause the groundwater level to drop, deplete reserves, and trigger geological hazards like land subsidence. The North China Plain (NCP) has experienced both subsidence and groundwater depletion due to over-extraction in the past 70 years. In this study, we used MT-InSAR technology and ascending C-band Sentinel-1 SAR data from 2017 to 2023 to study land deformation in the junction area of Shijiazhuang–Baoding–Cangzhou–Hengshui. We identified multiple subsidence funnels with a maximum rate exceeding −150 mm/year and a total deformation surpassing 600 mm. Seasonal decomposition methods accurately separated seasonal signals in the time-series deformation and groundwater level data. An exponential function model applied to long-term deformation showed no significant decrease in subsidence in severely affected areas. By modeling seasonal deformation and seasonal groundwater levels, we determined the elastic skeletal storage coefficients (Ske) to be in the range of 1.02 × 10−3~6.53 × 10−3 in subsidence areas. We obtained the spatiotemporal evolution of the total groundwater storage (TGWS), irreversible ground storage (IGWS), and recoverable ground storage (RGWS). The TGWS and IGWS decreased annually while the RGWS increased, which is attributable to the implementation of the South-to-North Water Diversion Project (SNWDP) and the issuance of groundwater withdrawal policies in the NCP. Full article
(This article belongs to the Special Issue Monitoring Geohazard from Synthetic Aperture Radar Interferometry)
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15 pages, 230 KiB  
Article
Bruce Springsteen, Rock Poetry, and Spatial Politics of the Promised Land
by Shankhadeep Chattopadhyay
Humanities 2024, 13(3), 75; https://doi.org/10.3390/h13030075 (registering DOI) - 13 May 2024
Abstract
The humanistic-geographical associations of popular music foster the potential to articulate the production and reproduction of an activity-centered politicized ontology of space in the everyday social life of any creative communitarian framework where an alternative set of lifestyles, choices, and tastes engage in [...] Read more.
The humanistic-geographical associations of popular music foster the potential to articulate the production and reproduction of an activity-centered politicized ontology of space in the everyday social life of any creative communitarian framework where an alternative set of lifestyles, choices, and tastes engage in a constant play. A cursory glimpse at the (counter-)cultural artistic productions of the American 1970s shows that the lyrical construction of real and imaginary geographical locales has remained a distinguishing motif in the song-writing techniques of the celebrated rock poets. In the case of Bruce Springsteen, whether it is the ‘badlands,’ constituting the rebellious and notorious young adults, or the ‘promised land,’ which is the desired destination of all his characters, his lyrical oeuvre has numerously provided an alternative sense of place. Springsteen’s lyrical and musical characterization of fleeting urban images like alleys, hotels, engines, streets, neon, pavements, locomotives, cars, etc., have not only captured the American cities under the changing regime of capital accumulation but also contributed to the inseparability of everyday social lives and modern urban experiences. Against the backdrop of this argument, this article seeks to explore how the socio-political and cultural aesthetics of Springsteen’s song stories unfurl distinct spatial poetics through their musical language. Also, the article attempts to delineate how Springsteen’s unabashed celebration of the working-class geography of the American 1970s unveils a site of cultural struggle, wherein existing social values are reconstructed amidst imaginary landscapes and discursive strategies of resistance are weaved. Full article
(This article belongs to the Special Issue Music and the Written Word)
24 pages, 10693 KiB  
Article
A Modified Enthalpic Lattice Boltzmann Method for Simulating Conjugate Heat Transfer Problems in Non-Homogeneous Media
by Vinicius Akyo Matsuda, Ivan Talão Martins, Debora Carneiro Moreira, Luben Cabezas-Gómez and Enio Pedone Bandarra Filho
Inventions 2024, 9(3), 57; https://doi.org/10.3390/inventions9030057 (registering DOI) - 13 May 2024
Abstract
In this study, we introduced modifications to a prior existing enthalpic lattice Boltzmann method (LBM) tailored for simulating the conjugate heat transfer phenomena in non-homogeneous media with time-dependent thermal properties. Our approach is based upon the incorporation of the remaining terms of a [...] Read more.
In this study, we introduced modifications to a prior existing enthalpic lattice Boltzmann method (LBM) tailored for simulating the conjugate heat transfer phenomena in non-homogeneous media with time-dependent thermal properties. Our approach is based upon the incorporation of the remaining terms of a conservative energy equation, excluding only the terms regarding flow compressibility and viscous dissipation, thereby accounting for the local and transient variations in the thermophysical properties. The solutions of verification tests, comprising assessments of both transient and steady-state solutions, validated the accuracy of the proposed model, further bolstering its reliability for analyzing heat transfer processes. The modified model was then used to perform an analysis on structured cavities under free convection, revealing compelling insights, particularly regarding transient regimes, demonstrating that the structured cavities exhibit a beneficial impact on enhancing the heat transfer processes, hence providing insights for potential design enhancements in heat exchangers. These results demonstrate the potential of our modified enthalpic LBM approach for simulating complex heat transfer phenomena in non-homogeneous media and structured geometries, offering valuable results for heat exchanger engineering and optimization. Full article
(This article belongs to the Special Issue Innovations in Heat Exchangers)
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22 pages, 6700 KiB  
Article
Identification of Shipborne VHF Radio Based on Deep Learning with Feature Extraction
by Liang Chen and Jiayu Liu
J. Mar. Sci. Eng. 2024, 12(5), 810; https://doi.org/10.3390/jmse12050810 (registering DOI) - 13 May 2024
Abstract
In the feature identification of maritime VHF radio communication signals, shipborne VHF communication technology follows the same international technical standards formulated by IMO, uses analog communication technology and uses the same communication channel in the same area, and cannot effectively achieve signal feature [...] Read more.
In the feature identification of maritime VHF radio communication signals, shipborne VHF communication technology follows the same international technical standards formulated by IMO, uses analog communication technology and uses the same communication channel in the same area, and cannot effectively achieve signal feature identification by adding feature elements in the process of signal modulation. How to effectively identify the ship using VHF radio has always been a technical difficulty in the field of ship perception. In this paper, based on the convolutional neural network, combined with the feasibility of CAM feature extraction and BiLSTM feature extraction in non-cooperative signal recognition, a deep learning recognition model of shipborne VHF radio communication signals is established, and the deep learning approach is employed to discern the features of VHF signals, thereby accomplishing the identification and classification of transmitting VHF radio stations. Several experiments are designed according to the characteristics of ship communication scenes at sea. The experimental data show that the method proposed in this paper can provide a new feasible path for ship target perception in terms of radio signal characteristics and identification. Full article
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26 pages, 6576 KiB  
Article
ARIMA-Driven Vegetable Pricing and Restocking Strategy for Dual Optimization of Freshness and Profitability in Supermarket Perishables
by Hongliang Li, Jun Liu, Jiangjie Qiu, Yunsen Zhou, Xu Zhang, Yuming Wang and Wei Guo
Sustainability 2024, 16(10), 4071; https://doi.org/10.3390/su16104071 (registering DOI) - 13 May 2024
Abstract
In the evolving landscape of perishable goods management, where the balance between minimizing waste and maximizing profitability is paramount, this work introduces an innovative approach to pricing and inventory decisions for products with limited shelf lives, focusing on vegetables in supermarkets. The contribution [...] Read more.
In the evolving landscape of perishable goods management, where the balance between minimizing waste and maximizing profitability is paramount, this work introduces an innovative approach to pricing and inventory decisions for products with limited shelf lives, focusing on vegetables in supermarkets. The contribution lies in its integration of an automated pricing and restocking decision model that leverages autoregressive integrated moving average (ARIMA) forecasting techniques alongside dynamic pricing strategies tailored to the goods’ freshness and remaining shelf life. The study uses a comprehensive sales, spoilage rates, and customer demand dataset to apply ARIMA forecasting for optimal restocking and adjusts prices dynamically based on product freshness, promoting competitive pricing and waste reduction. The results demonstrate the model’s effectiveness, reducing spoilage rates by up to 30% and increasing profitability margins by about 15%, highlighting its practical utility in real-world scenarios. The research highlights the potential for supermarkets to improve perishable goods inventory management, leading to significant economic benefits and reduced food waste. This study contributes to sustainable retail practices aligning with global responsible consumption and production initiatives, offering a scalable economic efficiency and environmental stewardship solution. Full article
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20 pages, 16805 KiB  
Article
Mineral Assemblages and Ore-Forming Physicochemical Conditions of the La’erma and Qiongmo Au–Se Deposits in the Western Qinling Orogen, Central China
by Jiajun Liu, Guoming Weng, Emmanuel John M. Carranza, Degao Zhai, Yinhong Wang, Fangfang Zhang, Shen Gao and Lei Xu
Minerals 2024, 14(5), 507; https://doi.org/10.3390/min14050507 (registering DOI) - 13 May 2024
Abstract
The La’erma and Qiongmo Au–Se deposits are characterized by a paragenetic Au–Se association hosted in the siliceous formation of the Cambrian Taiyangding Group in the western Qinling Orogen, central China. The La’erma and Qiongmo Au–Se deposits, which are considered to be the Carlin [...] Read more.
The La’erma and Qiongmo Au–Se deposits are characterized by a paragenetic Au–Se association hosted in the siliceous formation of the Cambrian Taiyangding Group in the western Qinling Orogen, central China. The La’erma and Qiongmo Au–Se deposits, which are considered to be the Carlin gold deposits, comprise a variety of selenides, native gold, and stibnite coexisting with baryte. Four stages have been recognized: sage I comprises pyrite and quartz with minor stibnite; stage II is composed mainly of sulfides; stage III is composed mainly of selenides; and stage IV is dominated by quartz–baryte–dickite. Stages II and III are the main metallogenic stages. Based on changes in mineral assemblages, combined with fluid inclusions and thermodynamic data, we evaluated the physicochemical conditions of the main metallogenic stages. The logfS2 values of ore-forming fluids at stage II ranged between −10.44 and −14.60 with logfSe2 being less than −10.70. Comparably, during stage III, which is characterized by numerous selenides, the logfS2 and logfSe2 ranged from −7.13 to −12.20 and −13.98 to −8.82, respectively. The occurrence of baryte during the mineralization suggests a consistently oxidizing condition, which can effectively remove Au from fluids. More importantly, this study emphasizes that the oxidizing condition was only a fundamental prerequisite for the deposition of selenides, and a high ∑Se/S ratio of the fluid ultimately controlled the precipitation of selenides. In the La’erma and Qiongmo deposits, intense water–rock reactions occurred as ore-forming fluids flowed into the Se-rich siliceous formations, resulting in an increase in the ∑Se/S ratio of the fluid and in the precipitation of selenides. Full article
(This article belongs to the Special Issue Selenium, Tellurium and Precious Metal Mineralogy)
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17 pages, 4522 KiB  
Article
Weighted Average Ensemble-Based PV Forecasting in a Limited Environment with Missing Data of PV Power
by Dae-Sung Lee and Sung-Yong Son
Sustainability 2024, 16(10), 4069; https://doi.org/10.3390/su16104069 (registering DOI) - 13 May 2024
Abstract
Photovoltaic (PV) power is subject to variability, influenced by factors such as meteorological conditions. This variability introduces uncertainties in forecasting, underscoring the necessity for enhanced forecasting models to support the large-scale integration of PV systems. Moreover, the presence of missing data during the [...] Read more.
Photovoltaic (PV) power is subject to variability, influenced by factors such as meteorological conditions. This variability introduces uncertainties in forecasting, underscoring the necessity for enhanced forecasting models to support the large-scale integration of PV systems. Moreover, the presence of missing data during the model development process significantly impairs model performance. To address this, it is essential to impute missing data from the collected datasets before advancing with model development. Recent advances in imputation methods, including Multivariate Imputation by Chained Equations (MICEs), K-Nearest Neighbors (KNNs), and Generative Adversarial Imputation Networks (GAINs), have exhibited commendable efficacy. Nonetheless, models derived solely from a single imputation method often exhibit diminished performance under varying weather conditions. Consequently, this study introduces a weighted average ensemble model that combines multiple imputation-based models. This innovative approach adjusts the weights according to “sky status” and evaluates the performance of single-imputation models using criteria such as sky status, root mean square error (RMSE), and mean absolute error (MAE), integrating them into a comprehensive weighted ensemble model. This model demonstrates improved RMSE values, ranging from 74.805 to 74.973, which corresponds to performance enhancements of 3.293–3.799% for KNN and 3.190–4.782% for MICE, thereby affirming its effectiveness in scenarios characterized by missing data. Full article
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19 pages, 1884 KiB  
Article
Exploring Disease Resistance in Pepper (Capsicum spp.) Germplasm Collection Using Fluidigm SNP Genotyping
by Nayoung Ro, Gi-An Lee, Ho-Cheol Ko, Hyeonseok Oh, Sukyeung Lee, Mesfin Haile and Jundae Lee
Plants 2024, 13(10), 1344; https://doi.org/10.3390/plants13101344 (registering DOI) - 13 May 2024
Abstract
This study utilized a diverse Capsicum accessions (5658) sourced from various species and geographical regions, deposited at the National Agrobiodiversity Center, Genebank. We employed 19 SNP markers through a Fluidigm genotyping system and screened these accessions against eight prevalent diseases of pepper. This [...] Read more.
This study utilized a diverse Capsicum accessions (5658) sourced from various species and geographical regions, deposited at the National Agrobiodiversity Center, Genebank. We employed 19 SNP markers through a Fluidigm genotyping system and screened these accessions against eight prevalent diseases of pepper. This study revealed accessions resistant to individual diseases as well as those exhibiting resistance to multiple diseases, including bacterial spot, anthracnose, powdery mildew, phytophthora root rot, and potyvirus. The C. chacoense accessions were identified as resistant materials against bacterial spot, anthracnose, powdery mildew, and phytophthora root rot, underscoring the robust natural defense mechanisms inherent in the wild Capsicum species and its potential uses as sources of resistance for breeding. C. baccatum species also demonstrated to be a promising source of resistance to major pepper diseases. Generally, disease-resistant germplasm has been identified from various Capsicum species. Originating from diverse locations such as Argentina, Bolivia, and the United Kingdom, these accessions consistently demonstrated resistance, indicating the widespread prevalence of disease-resistant traits across varied environments. Additionally, we selected ten pepper accessions based on their resistance to multiple diseases, including CMV, Phytophthora root rot, potyviruses, and TSWV, sourced from diverse geographical regions like Hungary, Peru, the United States, and the Netherlands. This comprehensive analysis provides valuable insights into disease resistance in Capsicum, crucial for fostering sustainable agricultural practices and advancing crop improvement through breeding strategies. Full article
(This article belongs to the Special Issue Molecular Breeding for Plant Disease Resistance)
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34 pages, 9515 KiB  
Review
Reviewing CAM-Based Deep Explainable Methods in Healthcare
by Dan Tang, Jinjing Chen, Lijuan Ren, Xie Wang, Daiwei Li and Haiqing Zhang
Appl. Sci. 2024, 14(10), 4124; https://doi.org/10.3390/app14104124 (registering DOI) - 13 May 2024
Abstract
The use of artificial intelligence within the healthcare sector is consistently growing. However, the majority of deep learning-based AI systems are of a black box nature, causing these systems to suffer from a lack of transparency and credibility. Due to the widespread adoption [...] Read more.
The use of artificial intelligence within the healthcare sector is consistently growing. However, the majority of deep learning-based AI systems are of a black box nature, causing these systems to suffer from a lack of transparency and credibility. Due to the widespread adoption of medical imaging for diagnostic purposes, the healthcare industry frequently relies on methods that provide visual explanations, enhancing interpretability. Existing research has summarized and explored the usage of visual explanation methods in the healthcare domain, providing introductions to the methods that have been employed. However, existing reviews are frequently used for interpretable analysis in the medical field ignoring comprehensive reviews on Class Activation Mapping (CAM) methods because researchers typically categorize CAM under the broader umbrella of visual explanations without delving into specific applications in the healthcare sector. Therefore, this study primarily aims to analyze the specific applications of CAM-based deep explainable methods in the healthcare industry, following the PICO (Population, Intervention, Comparison, Outcome) framework. Specifically, we selected 45 articles for systematic review and comparative analysis from three databases—PubMed, Science Direct, and Web of Science—and then compared eight advanced CAM-based methods using five datasets to assist in method selection. Finally, we summarized current hotspots and future challenges in the application of CAM in the healthcare field. Full article
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15 pages, 216 KiB  
Article
Patient Opinions about Virtual Consultations in Saudi Arabia: A Nationwide Cross-Sectional Study
by Saad Mohammed AlShareef and Abdullah Abdulaziz AlWabel
Healthcare 2024, 12(10), 1001; https://doi.org/10.3390/healthcare12101001 (registering DOI) - 13 May 2024
Abstract
There have been no nationwide studies of patient opinions regarding telehealth in Saudi Arabia to identify the factors that might influence patients’ perceptions and satisfaction. This was a prospective cross-sectional study of adults in the general population who last engaged with a healthcare [...] Read more.
There have been no nationwide studies of patient opinions regarding telehealth in Saudi Arabia to identify the factors that might influence patients’ perceptions and satisfaction. This was a prospective cross-sectional study of adults in the general population who last engaged with a healthcare practitioner via a virtual appointment. The participants were recruited by convenience sampling across Saudi Arabia between November 2023 and January 2024, completing a questionnaire that gathered data on (i) basic demographic and virtual consultation information and (ii) telehealth service delivery and technology based on the Telehealth Usability Questionnaire. Of the 916 participants, 53.7% were female, with a mean age of 47.2 (14.1) years. Nearly half attended primary care appointments, with the remainder attending a range of hospital specialties. Over 90% preferred having a virtual appointment over an in-person visit. About half had telephone consultations, while about a third had video calls through hospital-provided platforms; >90% found virtual appointments useful and convenient, easy to use, effective, reliable, and produced a favorable clinical interaction; and 97.4% were satisfied with their remote consultation experience despite the technical interruptions. The individuals who were less happy with their virtual consultation were significantly younger, lived in urban areas, attended specialty clinics, were seen by a psychologist, preferred in-person appointments, and had consultations by telephone. These data provide momentum to continue with and expand telehealth, especially through video calls, supported by educational initiatives. Full article
(This article belongs to the Section TeleHealth and Digital Healthcare)
32 pages, 866 KiB  
Article
Assessing the Impact of COVID-19 on Subjective Well-Being and Quality of Life in Mexico: Insights from Structural Equation Modeling
by Ignacio Alejandro Mendoza-Martínez, Edmundo Marroquín-Tovar, Jorge Pablo Rivas-Díaz, Araceli Durand, Gustavo Enrique Sauri-Alpuche and Blanca Rosa Garcia-Rivera
COVID 2024, 4(5), 605-636; https://doi.org/10.3390/covid4050041 (registering DOI) - 13 May 2024
Abstract
Amid the backdrop of the COVID-19 pandemic, the living conditions of the population were dramatically altered, with social distancing measures and the looming threat to public health leaving a profound impact on people’s lives. This study aims to assess the influence of COVID-19 [...] Read more.
Amid the backdrop of the COVID-19 pandemic, the living conditions of the population were dramatically altered, with social distancing measures and the looming threat to public health leaving a profound impact on people’s lives. This study aims to assess the influence of COVID-19 on subjective well-being and overall quality of life in Mexico. A structural model with latent variables was used. Data were extracted from the National Self-Reported Well-being Survey (SWLS) from October 2020 and January 2021, featuring a robust sample size of 3615 residents from urban areas in Mexico, all aged 18 and above. Findings revealed that around 38% of the variance in overall life satisfaction in October 2020 and January 2021 could be attributed to Personal well-being (0.231), Personal satisfaction (0.320), Satisfaction with the environment (0.076), and Negative emotional states (−0.116). In comparison, October 2019 to January 2020 saw a lower 20% explained variance, primarily associated with Personal well-being (0.184), Personal satisfaction (0.270), and Satisfaction with the environment (0.052). Reliability assessments, including Cronbach’s Alpha coefficients, Rho_a, and Composite Reliability, all surpassed 0.70 for each subscale. In addition, our study confirmed convergent validity, as the Average Variance Extracted (AVE) consistently exceeded 0.50 across all subscales, while the discriminant coefficient exceeded 0.70. Full article
(This article belongs to the Special Issue Analysis of Modeling and Statistics for COVID-19)
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16 pages, 602 KiB  
Review
Clinical Islet Xenotransplantation: Development of Isolation Protocol, Anti-Rejection Strategies, and Clinical Outcomes
by Shinichi Matsumoto and Kyohei Matsumoto
Cells 2024, 13(10), 828; https://doi.org/10.3390/cells13100828 (registering DOI) - 13 May 2024
Abstract
Allogeneic islet transplantation has become a standard therapy for unstable type 1 diabetes. However, considering the large number of type 1 diabetic patients, the shortage of donors is a serious issue. To address this issue, clinical islet xenotransplantation is conducted. The first clinical [...] Read more.
Allogeneic islet transplantation has become a standard therapy for unstable type 1 diabetes. However, considering the large number of type 1 diabetic patients, the shortage of donors is a serious issue. To address this issue, clinical islet xenotransplantation is conducted. The first clinical islet xenotransplantation was performed by a Swedish team using fetal pancreatic tissue. Thereafter, clinical trials of islet xenotransplantation were conducted in New Zealand, Russia, Mexico, Argentina, and China using neonatal pig islets. In clinical trials, fetal or neonatal pancreata are used because of the established reliable islet isolation methods. These trials demonstrate the method’s safety and efficacy. Currently, the limited number of source animal facilities is a problem in terms of promoting islet xenotransplantation. This limitation is due to the high cost of source animal facilities and the uncertain future of xenotransplantation. In the United States, the first xenogeneic heart transplantation has been performed, which could promote xenotransplantation. In Japan, to enhance xenotransplantation, the ‘Medical Porcine Development Association’ has been established. We hope that xenogeneic transplantation will become a clinical reality, serving to address the shortage of donors. Full article
(This article belongs to the Special Issue Islet Transplantation)
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