The 2023 MDPI Annual Report has
been released!
 
19 pages, 3639 KiB  
Article
Effects of Mactra chinenesis Peptides on Alcohol-Induced Acute Liver Injury and Intestinal Flora in Mice
by Dong Wu, Ming Cheng, Xiangzhou Yi, Guanghua Xia, Zhongyuan Liu, Haohao Shi and Xuanri Shen
Foods 2024, 13(10), 1431; https://doi.org/10.3390/foods13101431 (registering DOI) - 07 May 2024
Abstract
Food-borne bioactive peptides have shown promise in preventing and mitigating alcohol-induced liver injury. This study was the first to assess the novel properties of Mactra chinenesis peptides (MCPs) in mitigating acute alcoholic liver injury in mice, and further elucidated the underlying mechanisms associated [...] Read more.
Food-borne bioactive peptides have shown promise in preventing and mitigating alcohol-induced liver injury. This study was the first to assess the novel properties of Mactra chinenesis peptides (MCPs) in mitigating acute alcoholic liver injury in mice, and further elucidated the underlying mechanisms associated with this effect. The results showed that MCPs can improve lipid metabolism by modulating the AMPK signaling pathway, decreasing fatty acid synthase activity, and increasing carnitine palmitoyltransferase 1a activity. Meanwhile, MCPs ameliorate inflammation by inhibiting the NF-κB activation, leading to reduced levels of pro-inflammatory cytokines (tumor necrosis factor-α and interleukin-1β). Additionally, a 16S rDNA sequencing analysis revealed that MCPs can restore the balance of gut microbiota and increase the relative abundance of beneficial bacteria. These findings suggest that supplementation of MCPs could attenuate alcohol intake-induced acute liver injury, and, thus, may be utilized as a functional dietary supplement for the successful treatment and prevention of acute liver injury. Full article
(This article belongs to the Section Nutraceuticals, Functional Foods, and Novel Foods)
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17 pages, 4881 KiB  
Article
Intelligent Packet Priority Module for a Network of Unmanned Aerial Vehicles Using Manhattan Long Short-Term Memory
by Dino Budi Prakoso, Jauzak Hussaini Windiatmaja, Agus Mulyanto, Riri Fitri Sari and Rosdiadee Nordin
Drones 2024, 8(5), 183; https://doi.org/10.3390/drones8050183 (registering DOI) - 07 May 2024
Abstract
Unmanned aerial vehicles (UAVs) are becoming more common in wireless communication networks. Using UAVs can lead to network problems. An issue arises when the UAVs function in a network-access-limited environment with nodes causing interference. This issue could potentially hinder UAV network connectivity. This [...] Read more.
Unmanned aerial vehicles (UAVs) are becoming more common in wireless communication networks. Using UAVs can lead to network problems. An issue arises when the UAVs function in a network-access-limited environment with nodes causing interference. This issue could potentially hinder UAV network connectivity. This paper introduces an intelligent packet priority module (IPPM) to minimize network latency. This study analyzed Network Simulator–3 (NS-3) network modules utilizing Manhattan long short-term memory (MaLSTM) for packet classification of critical UAV, ground control station (GCS), or interfering nodes. To minimize network latency and packet delivery ratio (PDR) issues caused by interfering nodes, packets from prioritized nodes are transmitted first. Simulation results and evaluation show that our proposed intelligent packet priority module (IPPM) method outperformed previous approaches. The proposed IPPM based on MaLSTM implementation for the priority packet module led to a lower network delay and a higher packet delivery ratio. The performance of the IPPM averaged 62.2 ms network delay and 0.97 packet delivery ratio (PDR). The MaLSTM peaked at 97.5% accuracy. Upon further evaluation, the stability of LSTM Siamese models was observed to be consistent across diverse similarity functions, including cosine and Euclidean distances. Full article
(This article belongs to the Special Issue UAV-Assisted Mobile Wireless Networks and Applications)
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20 pages, 1412 KiB  
Article
Vibration Characteristic Research of 100 m New Polar Exploration Cruise Based on Finite Element Modeling
by Guohe Jiang, Yuhao Yuan, Hao Guo, Gang Wu and Zhenzhen Liu
J. Mar. Sci. Eng. 2024, 12(5), 779; https://doi.org/10.3390/jmse12050779 (registering DOI) - 07 May 2024
Abstract
Luxury cruise ships are high-end passenger ships with facilities on board for the leisure and entertainment of passengers, so the comfort of luxury cruise ships is a matter of great concern. In this paper, a finite element model of a new polar exploration [...] Read more.
Luxury cruise ships are high-end passenger ships with facilities on board for the leisure and entertainment of passengers, so the comfort of luxury cruise ships is a matter of great concern. In this paper, a finite element model of a new polar exploration cruise ship is established, and the wet modes of the whole ship are calculated using the virtual mass method and compared with the principal frequencies of the excitation forces to initially verify the rationality of the design of the structural vibration characteristics of the whole ship. The admittance matrix of the vibration velocity to excitation force was calculated by a frequency response analysis, and the vibration velocities at the stern plate and main engine foundations were tested during sailing. Then, the obtained propeller and main engine excitation forces were loaded into the finite element model; the vibration velocities of each compartment were calculated and compared with the compartment vibration velocity test values. The errors were within the engineering allowable range, verifying the accuracy of the excitation forces. The propeller and main engine excitation forces were loaded separately on the finite element model to calculate the vibration velocity of each cabin, and the contribution of the two excitation sources to the vibration velocity of each cabin was analyzed. It was found that the contribution of the excitation source to the cabin response was related to the relative position between the cabin and the excitation source. When the cabin was located in the cabin adjacent to or directly above a certain excitation source, the contribution of the excitation source to the cabin response was greater. When the cabin was farther away from both excitation sources, the contribution of the propeller excitation was greater. This provides a targeted reference for the preliminary vibration assessment and later vibration control of the new polar expedition cruise ship. Full article
(This article belongs to the Section Marine Hazards)
17 pages, 996 KiB  
Review
Genetic Variants in the ABCB1 and ABCG2 Gene Drug Transporters Involved in Gefitinib-Associated Adverse Reaction: A Systematic Review and Meta-Analysis
by Mariana Vieira Morau, Cecília Souto Seguin, Marília Berlofa Visacri, Eder de Carvalho Pincinato and Patricia Moriel
Genes 2024, 15(5), 591; https://doi.org/10.3390/genes15050591 (registering DOI) - 07 May 2024
Abstract
This systematic review and meta-analysis aimed to verify the association between the genetic variants of adenosine triphosphate (ATP)-binding cassette subfamily B member 1 (ABCB1) and ATP-binding cassette subfamily G member 2 (ABCG2) genes and the presence and severity of [...] Read more.
This systematic review and meta-analysis aimed to verify the association between the genetic variants of adenosine triphosphate (ATP)-binding cassette subfamily B member 1 (ABCB1) and ATP-binding cassette subfamily G member 2 (ABCG2) genes and the presence and severity of gefitinib-associated adverse reactions. We systematically searched PubMed, Virtual Health Library/Bireme, Scopus, Embase, and Web of Science databases for relevant studies published up to February 2024. In total, five studies were included in the review. Additionally, eight genetic variants related to ABCB1 (rs1045642, rs1128503, rs2032582, and rs1025836) and ABCG2 (rs2231142, rs2231137, rs2622604, and 15622C>T) genes were analyzed. Meta-analysis showed a significant association between the ABCB1 gene rs1045642 TT genotype and presence of diarrhea (OR = 5.41, 95% CI: 1.38–21.14, I2 = 0%), the ABCB1 gene rs1128503 TT genotype and CT + TT group and the presence of skin rash (OR = 4.37, 95% CI: 1.51–12.61, I2 = 0% and OR = 6.99, 95%CI: 1.61–30.30, I2= 0%, respectively), and the ABCG2 gene rs2231142 CC genotype and presence of diarrhea (OR = 3.87, 95% CI: 1.53–9.84, I2 = 39%). No ABCB1 or ABCG2 genes were positively associated with the severity of adverse reactions associated with gefitinib. In conclusion, this study showed that ABCB1 and ABCG2 variants are likely to exhibit clinical implications in predicting the presence of adverse reactions to gefitinib. Full article
(This article belongs to the Section Human Genomics and Genetic Diseases)
18 pages, 924 KiB  
Article
Modeling Yield of Irrigated and Rainfed Bean in Central and Southern Sinaloa State, Mexico, Based on Essential Climate Variables
by Omar Llanes Cárdenas, Rosa D. Estrella Gastélum, Román E. Parra Galaviz, Oscar G. Gutiérrez Ruacho, Jeován A. Ávila Díaz and Enrique Troyo Diéguez
Atmosphere 2024, 15(5), 573; https://doi.org/10.3390/atmos15050573 (registering DOI) - 07 May 2024
Abstract
The goal was to model irrigated (IBY) and rainfed (RBY) bean yields in central (Culiacán) and southern (Rosario) Sinaloa state as a function of the essential climate variables soil moisture, temperature, reference evapotranspiration, and precipitation. For Sinaloa, for the period 1982–2013 (October–March), the [...] Read more.
The goal was to model irrigated (IBY) and rainfed (RBY) bean yields in central (Culiacán) and southern (Rosario) Sinaloa state as a function of the essential climate variables soil moisture, temperature, reference evapotranspiration, and precipitation. For Sinaloa, for the period 1982–2013 (October–March), the following were calculated: (a) temperatures, (b) average degree days for the bean, (c) cumulative reference evapotranspiration, and (d) cumulative effective precipitation. For essential climate variables, (e) daily soil moisture obtained from the European Space Agency and (f) IBY and RBY from the Agrifood and Fisheries Information Service were used. Multiple linear regressions were significant for predicting IBY–RBY (dependent variables) as a function of essential climate variables (independent variables). The four models obtained were significantly predictive: IBY–Culiacán (Pearson correlation (PC) = 0.590 > Pearson critical correlation (CPC) = |0.349|), RBY–Culiacán (PC = 0.734 > CPC = |0.349|), IBY–Rosario (PC = 0.621 > CPC = |0.355|), and RBY–Rosario (PC = 0.532 > CPC = |0.349|). Due to the lack of irrigation depth data, many studies only focus on modeling RBY; this study is the first in Sinaloa to predict IBY and RBY based on essential climate variables, contributing to the production of sustainable food. Full article
(This article belongs to the Section Climatology)
14 pages, 674 KiB  
Article
Earliest Mule Remains from Early Bronze Age Central Anatolia
by Can Yümni Gündem
Animals 2024, 14(10), 1397; https://doi.org/10.3390/ani14101397 (registering DOI) - 07 May 2024
Abstract
This paper discusses the discoveries of early donkey and the earliest mule remains in Central Anatolia from the site Derekutuğun. This site represents the remains of a village dating back to the Early Bronze Age and Assyrian Trade Colonies period, associated with mining. [...] Read more.
This paper discusses the discoveries of early donkey and the earliest mule remains in Central Anatolia from the site Derekutuğun. This site represents the remains of a village dating back to the Early Bronze Age and Assyrian Trade Colonies period, associated with mining. The archaeofaunal assemblage was studied by the author and his team using classical archaeozoological methods. The dental remains of the Equidae found at Derekutuğun have been re-examined and are described in this article. The dental evidence indicates that donkeys, and possibly the earliest mules ever found in Central Anatolia, were kept at this site. Although the paper is based on the archaeozoological remains, written sources from the period also support the faunal identification. Derekutuğun was a small settlement that specialized in processing copper ore, and which was an important hub for a trade network because of its extensive mining and extraction operations. Full article
28 pages, 2589 KiB  
Review
AI-Driven Sensing Technology: Review
by Long Chen, Chenbin Xia, Zhehui Zhao, Haoran Fu and Yunmin Chen
Sensors 2024, 24(10), 2958; https://doi.org/10.3390/s24102958 (registering DOI) - 07 May 2024
Abstract
Machine learning and deep learning technologies are rapidly advancing the capabilities of sensing technologies, bringing about significant improvements in accuracy, sensitivity, and adaptability. These advancements are making a notable impact across a broad spectrum of fields, including industrial automation, robotics, biomedical engineering, and [...] Read more.
Machine learning and deep learning technologies are rapidly advancing the capabilities of sensing technologies, bringing about significant improvements in accuracy, sensitivity, and adaptability. These advancements are making a notable impact across a broad spectrum of fields, including industrial automation, robotics, biomedical engineering, and civil infrastructure monitoring. The core of this transformative shift lies in the integration of artificial intelligence (AI) with sensor technology, focusing on the development of efficient algorithms that drive both device performance enhancements and novel applications in various biomedical and engineering fields. This review delves into the fusion of ML/DL algorithms with sensor technologies, shedding light on their profound impact on sensor design, calibration and compensation, object recognition, and behavior prediction. Through a series of exemplary applications, the review showcases the potential of AI algorithms to significantly upgrade sensor functionalities and widen their application range. Moreover, it addresses the challenges encountered in exploiting these technologies for sensing applications and offers insights into future trends and potential advancements. Full article
(This article belongs to the Section State-of-the-Art Sensors Technologies)
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19 pages, 1580 KiB  
Article
Change in Dental Arch Parameters—Perimeter, Width and Length after Treatment with a Printed RME Appliance
by Vladimir Bogdanov, Greta Yordanova and Gergana Gurgurova
Appl. Sci. 2024, 14(10), 3959; https://doi.org/10.3390/app14103959 (registering DOI) - 07 May 2024
Abstract
One of the important parameters in orthodontics is the perimeter of the dental arch. Precise assessment is necessary in cases of maxillary constriction treated with a rapid maxillary expander (RME). The orthodontic software allows customization of the processes from diagnosis to manufacturing of [...] Read more.
One of the important parameters in orthodontics is the perimeter of the dental arch. Precise assessment is necessary in cases of maxillary constriction treated with a rapid maxillary expander (RME). The orthodontic software allows customization of the processes from diagnosis to manufacturing of the treatment device. The aim of the present study is to evaluate a relationship between the parameters of the dental arch—perimeter, width, and length—and to follow the changes during treatment. The study is based on the digital measurements of 3D models of 33 patients treated with a digitally planned and printed RME. In the results an increase of 3.99 mm in perimeter was achieved. The rest of the parameters were changed as follows: The width of the dental arch was increased in the premolar area by an average of 3.3 mm; in the area of the first molars, the increase was 4.41 mm; the length of the dental arch in the anterior segment was reduced by an average of 0.54 mm; and the whole length by 0.52 mm. Correlation between the studied variables was described by linear equations. In conclusion, rapid maxillary expansion is a reliable method for gaining predictable space in the dental arch. Full article
(This article belongs to the Special Issue Applications of Digital Dental Technology in Orthodontics)
20 pages, 1720 KiB  
Article
Integrating Cognitive Competency, Social Competency and Risk Propensity with the Theory of Planned Behaviour to Attain Sustainable-Development-Goal-8-Driven Sustainable Entrepreneurial Intentions
by Simpi Malhotra and Ravi Kiran
Sustainability 2024, 16(10), 3888; https://doi.org/10.3390/su16103888 (registering DOI) - 07 May 2024
Abstract
This paper empirically examines whether integrating entrepreneurial abilities with the theory of perceived behaviour positively influences Sustainable-Development-Goal-8-driven sustainable entrepreneurial intentions (SDG-8 SEIs). The data used in this study were gathered from 540 students from top-ranked Indian engineering colleges that offer entrepreneurship courses and [...] Read more.
This paper empirically examines whether integrating entrepreneurial abilities with the theory of perceived behaviour positively influences Sustainable-Development-Goal-8-driven sustainable entrepreneurial intentions (SDG-8 SEIs). The data used in this study were gathered from 540 students from top-ranked Indian engineering colleges that offer entrepreneurship courses and have access to company incubators. According to the theory of planned behaviour (TPB), perceived behavioural control, subjective norms, and entrepreneurial drive are the three elements of perceived entrepreneurial behaviour. The TPB’s dimensions in this study have entrepreneurial competencies as their antecedents. Cognitive competency, risk propensity, and social competency and resilience are antecedents of the TPB’s dimensions. One entrepreneurial viewpoint uses sustainable UNDP-SDG-8 as a metric for assessing intentions; its objectives are the promotion of inclusive and sustainable economic growth, full and productive employment, and decent work for all. This study used partial least squares structural equation modelling (PLS-SEM). According to the findings, engineering students in India are more likely to have entrepreneurial-focused intentions based on sustainability if they adhere to the TPB’s dimensions along with additional constructs. Using an expanded TPB model, we show that the TPB has learnable and stimulating antecedents, with these having a positive effect on SDG-8 SEIs, thus extending entrepreneurial activity in India. Policymakers, universities, and students will find these results very intriguing. The TPB’s dimensions and three additional dimensions are proposed as antecedents in a new conceptual model aimed at sustainable entrepreneurship in this study. Full article
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12 pages, 422 KiB  
Article
Superinfections of the Spine: A Single-Institution Experience
by Anthony K. Chiu, Bibhas Amatya, Idris Amin, Amit S. Ratanpal, Alexandra Baker Lutz, Brian M. Shear, Ivan B. Ye, Robin Fencel, Louis J. Bivona, Eugene Y. Koh, Julio J. Jauregui, Steven C. Ludwig and Daniel L. Cavanaugh
J. Clin. Med. 2024, 13(10), 2739; https://doi.org/10.3390/jcm13102739 (registering DOI) - 07 May 2024
Abstract
Background/Objectives: A superinfection occurs when a new, secondary organism colonizes an existing infection. Spine infections are associated with high patient morbidity and sometimes require multiple irrigations and debridements (I&Ds). When multiple I&Ds are required, the risk of complications increases. The purpose of this [...] Read more.
Background/Objectives: A superinfection occurs when a new, secondary organism colonizes an existing infection. Spine infections are associated with high patient morbidity and sometimes require multiple irrigations and debridements (I&Ds). When multiple I&Ds are required, the risk of complications increases. The purpose of this study was to report our experience with spine superinfections and determine which patients are typically affected. Methods: A retrospective case series of spine superinfections and a retrospective case–control analysis were conducted. Data were collected manually from electronic medical records. Spine I&Ds were identified. Groups were created for patients who had multiple I&Ds for (1) a recurrence of the same causative organism or (2) a superinfection with a novel organism. Preoperative demographic, clinical, and microbiologic data were compared between these two outcomes. A case series of superinfections with descriptive data was constructed. Lastly, two illustrative cases were provided in a narrative format. Results: A total of 92 patients were included in this analysis. Superinfections occurred after 6 out of the 92 (7%) initial I&Ds and were responsible for 6 out of the 24 (25%) repeat I&Ds. The preoperative erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) of the patients with a superinfection were significantly lower than those in the control group (p = 0.022 and p = 0.032). Otherwise, the observed differences in the preoperative variables were not statistically different. In the six cases of superinfection, the presence of high-risk comorbidities, a history of substance abuse, or a lack of social support were commonly observed. The superinfecting organisms included Candida, Pseudomonas, Serratia, Klebsiella, Enterobacter, and Staphylococcus species. Conclusions: Superinfections are a devastating complication requiring reoperation after initial spine I&D. Awareness of the possibility of superinfection and common patient archetypes can be helpful for clinicians and care teams. Future work is needed to examine how to identify, help predict, and prevent spine superinfections. Full article
(This article belongs to the Special Issue Neurosurgery and Spine Surgery: From Up-to-Date Practitioners)
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20 pages, 1737 KiB  
Article
CosUKG: A Representation Learning Framework for Uncertain Knowledge Graphs
by Qiuhui Shen and Aiyan Qu
Mathematics 2024, 12(10), 1419; https://doi.org/10.3390/math12101419 (registering DOI) - 07 May 2024
Abstract
Knowledge graphs have been extensively studied and applied, but most of these studies assume that the relationship facts in the knowledge graph are correct and deterministic. However, in the objective world, there inevitably exist uncertain relationship facts. The existing research lacks effective representation [...] Read more.
Knowledge graphs have been extensively studied and applied, but most of these studies assume that the relationship facts in the knowledge graph are correct and deterministic. However, in the objective world, there inevitably exist uncertain relationship facts. The existing research lacks effective representation of such uncertain information. In this regard, we propose a novel representation learning framework called CosUKG, which is specifically designed for uncertain knowledge graphs. This framework models uncertain information by measuring the cosine similarity between transformed vectors and actual target vectors, effectively integrating uncertainty into the embedding process of the knowledge graph while preserving its structural information. Through multiple experiments on three public datasets, the superiority of the CosUKG framework in representing uncertain knowledge graphs is demonstrated. It achieves improved representation accuracy of uncertain information without increasing model complexity or weakening structural information. Full article
(This article belongs to the Section Mathematics and Computer Science)
16 pages, 9570 KiB  
Review
Investigating the Balance between Structural Conservation and Functional Flexibility in Photosystem I
by Nathan Nelson
Int. J. Mol. Sci. 2024, 25(10), 5073; https://doi.org/10.3390/ijms25105073 (registering DOI) - 07 May 2024
Abstract
Photosynthesis, as the primary source of energy for all life forms, plays a crucial role in maintaining the global balance of energy, entropy, and enthalpy in living organisms. Among its various building blocks, photosystem I (PSI) is responsible for light-driven electron transfer, crucial [...] Read more.
Photosynthesis, as the primary source of energy for all life forms, plays a crucial role in maintaining the global balance of energy, entropy, and enthalpy in living organisms. Among its various building blocks, photosystem I (PSI) is responsible for light-driven electron transfer, crucial for generating cellular reducing power. PSI acts as a light-driven plastocyanin-ferredoxin oxidoreductase and is situated in the thylakoid membranes of cyanobacteria and the chloroplasts of eukaryotic photosynthetic organisms. Comprehending the structure and function of the photosynthetic machinery is essential for understanding its mode of action. New insights are offered into the structure and function of PSI and its associated light-harvesting proteins, with a specific focus on the remarkable structural conservation of the core complex and high plasticity of the peripheral light-harvesting complexes. Full article
(This article belongs to the Special Issue New Insights into Photosystem I)
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31 pages, 3425 KiB  
Article
Production and Optimisation of Fermented Pumpkin-Based Mature Coconut Water Kefir Beverage Using Response Surface Methodology
by Wee Yin Koh, Xiao Xian Lim, Ban Hock Khor, Babak Rasti, Thuan Chew Tan, Rovina Kobun and Utra Uthumporn
Beverages 2024, 10(2), 34; https://doi.org/10.3390/beverages10020034 (registering DOI) - 07 May 2024
Abstract
Fermentation of pumpkin puree and mature coconut water using water kefir grains is a potential method for producing a novel functional non-dairy-based probiotic drink. In the present study, response surface methodology based on Box–Behnken design (RSM-BBD) was used to optimise fermentation temperature and [...] Read more.
Fermentation of pumpkin puree and mature coconut water using water kefir grains is a potential method for producing a novel functional non-dairy-based probiotic drink. In the present study, response surface methodology based on Box–Behnken design (RSM-BBD) was used to optimise fermentation temperature and substrates’ concentrations. The optimised fermentation temperature, pumpkin puree, and brown sugar concentrations of pumpkin-based mature coconut water kefir beverage (PWKC) were 27 °C, 20%, and 10% w/v, respectively. The optimised PWKC (PWKCopt) obtained an overall acceptability (OA) score of 4.03, with a desirable Lactobacillus count (6.41 Log CFU/mL), 0.68% v/v lactic acid content, 31% of water kefir grains’ biomass growth rate, and fermentation time (to reach pH 4.5) of 4.5 h. The optimized beverage, PWKCopt, contained 3.26% proteins, 2.75% dietary fibre, 2186.33 mg/L of potassium, 180.67 mg/L phosphorus, and 137.33 mg/L calcium and had a total phenolic content of 89.93 mg GAE/100 mL, flavonoid content of 49.94 mg QE/100 mL, and carotenoid content of 33.24 mg/100 mL, with antioxidant activity (FRAP: 169.17 mM Fe(II)/100 mL, IC50 value of DPPH free radicals scavenging activity: 27.17 mg/mL). Water kefir microorganisms in PWKCopt remained stable for at least 56 days at 4 °C. Therefore, PWKCopt might potentially serve as a value-added product, offering a basis for sustainable development within both the coconut and pumpkin industries. Full article
(This article belongs to the Topic Advances in Analysis of Food and Beverages)
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21 pages, 944 KiB  
Review
A Review of Intelligent Airfoil Aerodynamic Optimization Methods Based on Data-Driven Advanced Models
by Liyue Wang, Haochen Zhang, Cong Wang, Jun Tao, Xinyue Lan, Gang Sun and Jinzhang Feng
Mathematics 2024, 12(10), 1417; https://doi.org/10.3390/math12101417 (registering DOI) - 07 May 2024
Abstract
With the rapid development of artificial intelligence technology, data-driven advanced models have provided new ideas and means for airfoil aerodynamic optimization. As the advanced models update and iterate, many useful explorations and attempts have been made by researchers on the integrated application of [...] Read more.
With the rapid development of artificial intelligence technology, data-driven advanced models have provided new ideas and means for airfoil aerodynamic optimization. As the advanced models update and iterate, many useful explorations and attempts have been made by researchers on the integrated application of artificial intelligence and airfoil aerodynamic optimization. In this paper, many critical aerodynamic optimization steps where data-driven advanced models are employed are reviewed. These steps include geometric parameterization, aerodynamic solving and performance evaluation, and model optimization. In this way, the improvements in the airfoil aerodynamic optimization area led by data-driven advanced models are introduced. These improvements involve more accurate global description of airfoil, faster prediction of aerodynamic performance, and more intelligent optimization modeling. Finally, the challenges and prospect of applying data-driven advanced models to aerodynamic optimization are discussed. Full article
(This article belongs to the Special Issue Advanced Model Optimization and Data Fusion Methods in Aircraft)
20 pages, 923 KiB  
Article
Assessing the Potential of Onboard LiDAR-Based Application to Detect the Quality of Tree Stems in Cut-to-Length (CTL) Harvesting Operations
by Anwar Sagar, Kalle Kärhä, Kalle Einola and Anssi Koivusalo
Forests 2024, 15(5), 818; https://doi.org/10.3390/f15050818 (registering DOI) - 07 May 2024
Abstract
This paper investigated the integration of LiDAR technology in cut-to-length (CTL) harvesting machines to enhance tree selection accuracy and efficiency. In the evolution of CTL forest machines towards improving operational efficiency and operator conditions, challenges persist in manual tree selection during thinning operations, [...] Read more.
This paper investigated the integration of LiDAR technology in cut-to-length (CTL) harvesting machines to enhance tree selection accuracy and efficiency. In the evolution of CTL forest machines towards improving operational efficiency and operator conditions, challenges persist in manual tree selection during thinning operations, especially under unmarked conditions and complex environments. These can be improved due to advances in technology. We studied the potential of LiDAR systems in assisting harvester operators, aiming to mitigate workload, reduce decision errors, and optimize the harvesting workflow. We used both synthetic and real-world 3D point cloud data sets for tree stem defect analysis. The former was crafted using a 3D modelling engine, while the latter originated from forest observations using 3D LiDAR on a CTL harvester. Both data sets contained instances of tree stem defects that should be detected. We demonstrated the potential of LiDAR technology: The analysis of synthetic data yielded a Root Mean Square Error (RMSE) of 0.00229 meters (m) and an RMSE percentage of 0.77%, demonstrating high detection accuracy. The real-world data also showed high accuracy, with an RMSE of 0.000767 m and an RMSE percentage of 1.39%. Given these results, we recommend using on-board LiDAR sensor technologies for collecting and analyzing data on tree/forest quality in real-time. This will help overcome existing barriers and drive forest operations toward enhanced efficiency and sustainability. Full article
(This article belongs to the Section Forest Operations and Engineering)
20 pages, 5088 KiB  
Article
Building Information Modeling/Building Energy Simulation Integration Based on Quantitative and Interpretative Interoperability Analysis
by Carolina Fernandes Vaz, Luísa Lopes de Freitas Guilherme, Ana Carolina Fernandes Maciel, André Luis De Araujo, Bruno Barzellay Ferreira Da Costa and Assed Naked Haddad
Infrastructures 2024, 9(5), 84; https://doi.org/10.3390/infrastructures9050084 (registering DOI) - 07 May 2024
Abstract
The integration between the building information modeling (BIM) methodology and the building energy simulation (BES) can contribute to a thermo-energetic analysis since the model generated and fed into BIM is exported to simulation software. This integration, also called interoperability, is satisfactory when the [...] Read more.
The integration between the building information modeling (BIM) methodology and the building energy simulation (BES) can contribute to a thermo-energetic analysis since the model generated and fed into BIM is exported to simulation software. This integration, also called interoperability, is satisfactory when the information flow is carried out without the loss of essential information. Several studies point out interoperability flaws between the methodologies; however, most of them occur in low-geometry-complexity models during quantitative experiments. The purpose of this research was to analyze the BIM/BES integration based on a quantitative and interpretative interoperability analysis of two buildings with complex geometries located on the UFU Campus (library and Building 5T) in Uberlândia, Brazil. To accomplish this, two geometries of each building were modeled, detailed, and simplified to analyze the data import, workflow, and model correction in the BES software. In the case of the library, the integration of Revit with DesignBuilder and IES-VE was analyzed, and in Block 5T, Revit was used with DesignBuilder and eQUEST. The BES software that presented the best integration with Revit for complex geometries was DesignBuilder, with the best performance being in the interpretative criteria. It was concluded that the simplification of complex geometries is essential for better data transfers. To determine the BES software that has better integration with BIM, a comprehensive evaluation is necessary, considering not only data transfers but also ease of working within BES software, the possibility of corrections in these, as well as the availability of tutorials and developer support. Full article
(This article belongs to the Special Issue Smart, Sustainable and Resilient Infrastructures, 2nd Edition)
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25 pages, 2921 KiB  
Article
Optimization of an IPMSM for Constant-Angle Square-Wave Control of a BLDC Drive
by Mitja Garmut, Simon Steentjes and Martin Petrun
Mathematics 2024, 12(10), 1418; https://doi.org/10.3390/math12101418 (registering DOI) - 07 May 2024
Abstract
Interior permanent magnet synchronous machines (IPMSMs) driven with a square-wave control (i.e., six-step, block, or 120 control), known commonly as brushless direct current (BLDC) drives, are used widely due to their high power density and control simplicity. The advance firing (AF) angle [...] Read more.
Interior permanent magnet synchronous machines (IPMSMs) driven with a square-wave control (i.e., six-step, block, or 120 control), known commonly as brushless direct current (BLDC) drives, are used widely due to their high power density and control simplicity. The advance firing (AF) angle is employed to achieve improved operation characteristics of the drive. The AF angle is, in general, applied to compensate for the commutation effects. In the case of an IPMSM, the AF angle can also be adjusted to exploit reluctance torque. In this paper, a detailed study was performed to understand its effect on the drive’s performance in regard to reluctance torque. Furthermore, a multi-objective optimization of the machine’s cross-section using neural network models was conducted to enhance performance at a constant AF angle. The reference and improved machine designs were evaluated in a system-level simulation, where the impact was considered of the commutation of currents. A significant improvement in the machine performance was achieved after optimizing the geometry and implementing a fixed AF angle of 10. Full article
32 pages, 1552 KiB  
Article
Mechanics 4.0 and Mechanical Engineering Education
by Eusebio Jiménez López, Pablo Alberto Limon Leyva, Armando Ambrosio López, Francisco Javier Ochoa Estrella, Juan José Delfín Vázquez, Baldomero Lucero Velázquez and Víctor Manuel Martínez Molina
Machines 2024, 12(5), 320; https://doi.org/10.3390/machines12050320 (registering DOI) - 07 May 2024
Abstract
Industry 4.0 is an industrial paradigm that is causing changes in form and substance in factories, companies and businesses around the world and is impacting work and education in general. In fact, the disruptive technologies that frame the Fourth Industrial Revolution have the [...] Read more.
Industry 4.0 is an industrial paradigm that is causing changes in form and substance in factories, companies and businesses around the world and is impacting work and education in general. In fact, the disruptive technologies that frame the Fourth Industrial Revolution have the potential to improve and optimize manufacturing processes and the entire value chain, which could lead to an exponential evolution in the production and distribution of goods and services. All these changes imply that the fields of engineering knowledge must be oriented towards the concept of Industry 4.0, for example, Mechanical Engineering. The development of various physical assets that are used by cyber-physical systems and digital twins is based on mechanics. However, the specialized literature on Industry 4.0 says little about the importance of mechanics in the new industrial era, and more importance is placed on the evolution of Information and Communication Technologies and artificial intelligence. This article presents a frame of reference for the importance of Mechanical Engineering in Industry 4.0 and proposes an extension to the concept of Mechanics 4.0, recently defined as the relationship between mechanics and artificial intelligence. To analyze Mechanical Engineering in Industry 4.0, the criteria of the four driving forces that defined mechanics in the Third Industrial Revolution were used. An analysis of Mechanical Engineering Education in Industry 4.0 is presented, and the concept of Mechanical Engineering 4.0 Education is improved. Finally, the importance of making changes to the educational models of engineering education is described. Full article
(This article belongs to the Section Robotics, Mechatronics and Intelligent Machines)
17 pages, 2769 KiB  
Article
Osteosarcoma-Induced Pain Is Mediated by Glial Cell Activation in the Spinal Dorsal Horn, but Not Capsaicin-Sensitive Nociceptive Neurons: A Complex Functional and Morphological Characterization in Mice
by Noémi Bencze, Bálint Scheich, Éva Szőke, Imola Wilhelm, Sándor Körmöndi, Bálint Botz and Zsuzsanna Helyes
Cancers 2024, 16(10), 1788; https://doi.org/10.3390/cancers16101788 (registering DOI) - 07 May 2024
Abstract
Bone cancer and its related chronic pain are huge clinical problems since the available drugs are often ineffective or cannot be used long term due to a broad range of side effects. The mechanisms, mediators and targets need to be identified to determine [...] Read more.
Bone cancer and its related chronic pain are huge clinical problems since the available drugs are often ineffective or cannot be used long term due to a broad range of side effects. The mechanisms, mediators and targets need to be identified to determine potential novel therapies. Here, we characterize a mouse bone cancer model induced by intratibial injection of K7M2 osteosarcoma cells using an integrative approach and investigate the role of capsaicin-sensitive peptidergic sensory nerves. The mechanical pain threshold was assessed by dynamic plantar aesthesiometry, limb loading by dynamic weight bearing, spontaneous pain-related behaviors via observation, knee diameter with a digital caliper, and structural changes by micro-CT and glia cell activation by immunohistochemistry in BALB/c mice of both sexes. Capsaicin-sensitive peptidergic sensory neurons were defunctionalized by systemic pretreatment with a high dose of the transient receptor potential vanilloid 1 (TRPV1) agonist resiniferatoxin (RTX). During the 14- and 28-day experiments, weight bearing on the affected limb and the paw mechanonociceptive thresholds significantly decreased, demonstrating secondary mechanical hyperalgesia. Signs of spontaneous pain and osteoplastic bone remodeling were detected both in male and female mice without any sex differences. Microglia activation was shown by the increased ionized calcium-binding adapter molecule 1 (Iba1) immunopositivity on day 14 and astrocyte activation by the enhanced glial fibrillary acidic protein (GFAP)-positive cell density on day 28 in the ipsilateral spinal dorsal horn. Interestingly, defunctionalization of the capsaicin-sensitive afferents representing approximately 2/3 of the nociceptive fibers did not alter any functional parameters. Here, we provide the first complex functional and morphological characterization of the K7M2 mouse osteosarcoma model. Bone-cancer-related chronic pain and hyperalgesia are likely to be mediated by central sensitization involving neuroinflammation via glial cell activation in the spinal dorsal horn, but not the capsaicin-sensitive sensory neuronal system. Full article
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27 pages, 1366 KiB  
Article
A Set of Accurate Dispersive Nonlinear Wave Equations
by Hongwei Bian, Jie Xu and Zhili Zou
J. Mar. Sci. Eng. 2024, 12(5), 778; https://doi.org/10.3390/jmse12050778 (registering DOI) - 07 May 2024
Abstract
In this study, a set of accurate dispersive nonlinear wave equations is established, using the wave velocity and free surface elevation as variables. These equations improve upon previous equations in which the velocity potential is used as a variable by considering the rotational [...] Read more.
In this study, a set of accurate dispersive nonlinear wave equations is established, using the wave velocity and free surface elevation as variables. These equations improve upon previous equations in which the velocity potential is used as a variable by considering the rotational wave motion and by adding a second-order bottom slope term that applies to general situations, allowing the equations to consider the influence of rapidly changing, horizontal, two-dimensional bottom topographies. The problem of the inaccuracy of the integral calculations used in previous equations in nearshore areas is solved by approximating the integral calculations into differential calculations, and a set of coupled wave equations is established by keeping the free surface elevation and the horizontal velocity constant, thus allowing the calculation of nearshore wave-generated currents. The benefits of the current model are confirmed through comparisons with corresponding laboratory experimental findings and are illustrated through a comparison with the numerical outcomes of other pertinent models. Full article
(This article belongs to the Section Ocean Engineering)
19 pages, 2614 KiB  
Article
Numerical Simulation and Deformation Prediction of Deep Pit Based on PSO-BP Neural Network Inversion of Soil Parameters
by Qingwang Li, Feng Cheng and Xinran Zhang
Sensors 2024, 24(10), 2959; https://doi.org/10.3390/s24102959 (registering DOI) - 07 May 2024
Abstract
The finite element numerical simulation results of deep pit deformation are greatly influenced by soil layer parameters, which are crucial in determining the accuracy of deformation prediction results. This study employs the orthogonal experimental design to determine the combinations of various soil layer [...] Read more.
The finite element numerical simulation results of deep pit deformation are greatly influenced by soil layer parameters, which are crucial in determining the accuracy of deformation prediction results. This study employs the orthogonal experimental design to determine the combinations of various soil layer parameters in deep pits. Displacement values at specific measurement points were calculated using PLAXIS 3D under these varying parameter combinations to generate training samples. The nonlinear mapping ability of the Back Propagation (BP) neural network and Particle Swarm Optimization (PSO) were used for sample global optimization. Combining these with actual onsite measurements, we inversely calculate soil layer parameter values to update the input parameters for PLAXIS 3D. This allows us to conduct dynamic deformation prediction studies throughout the entire excavation process of deep pits. The results indicate that the use of the PSO-BP neural network for inverting soil layer parameters effectively enhances the convergence speed of the BP neural network model and avoids the issue of easily falling into local optimal solutions. The use of PLAXIS 3D to simulate the excavation process of the pit accurately reflects the dynamic changes in the displacement of the retaining structure, and the numerical simulation results show good agreement with the measured values. By updating the model parameters in real-time and calculating the pile displacement under different working conditions, the absolute errors between the measured and simulated values of pile top vertical displacement and pile body maximum horizontal displacement can be effectively reduced. This suggests that inverting soil layer parameters using measured values from working conditions is a feasible method for dynamically predicting the excavation process of the pit. The research results have some reference value for the selection of soil layer parameters in similar areas. Full article
(This article belongs to the Section Smart Agriculture)
19 pages, 545 KiB  
Review
An Overview of Approaches and Methods for the Cognitive Workload Estimation in Human–Machine Interaction Scenarios through Wearables Sensors
by Sabrina Iarlori, David Perpetuini, Michele Tritto, Daniela Cardone, Alessandro Tiberio, Manish Chinthakindi, Chiara Filippini, Luca Cavanini, Alessandro Freddi, Francesco Ferracuti, Arcangelo Merla and Andrea Monteriù
BioMedInformatics 2024, 4(2), 1155-1173; https://doi.org/10.3390/biomedinformatics4020064 (registering DOI) - 07 May 2024
Abstract
Background: Human-Machine Interaction (HMI) has been an important field of research in recent years, since machines will continue to be embedded in many human actvities in several contexts, such as industry and healthcare. Monitoring in an ecological mannerthe cognitive workload (CW) of users, [...] Read more.
Background: Human-Machine Interaction (HMI) has been an important field of research in recent years, since machines will continue to be embedded in many human actvities in several contexts, such as industry and healthcare. Monitoring in an ecological mannerthe cognitive workload (CW) of users, who interact with machines, is crucial to assess their level of engagement in activities and the required effort, with the goal of preventing stressful circumstances. This study provides a comprehensive analysis of the assessment of CW using wearable sensors in HMI. Methods: this narrative review explores several techniques and procedures for collecting physiological data through wearable sensors with the possibility to integrate these multiple physiological signals, providing a multimodal monitoring of the individuals’CW. Finally, it focuses on the impact of artificial intelligence methods in the physiological signals data analysis to provide models of the CW to be exploited in HMI. Results: the review provided a comprehensive evaluation of the wearables, physiological signals, and methods of data analysis for CW evaluation in HMI. Conclusion: the literature highlighted the feasibility of employing wearable sensors to collect physiological signals for an ecological CW monitoring in HMI scenarios. However, challenges remain in standardizing these measures across different populations and contexts. Full article
(This article belongs to the Special Issue Feature Papers in Applied Biomedical Data Science)
25 pages, 3629 KiB  
Article
Performance Optimization Design Study of Box-Type Substations Subjected to the Combined Effects of Wind, Snow, and Seismic Loads
by Meixing Guo, Mingzhu Fang, Lingyu Wang, Jie Hu and Jin Qi
Appl. Sci. 2024, 14(10), 3958; https://doi.org/10.3390/app14103958 (registering DOI) - 07 May 2024
Abstract
As a pivotal node in both urban and rural power grids, the box-type substation not only serves the functions of power conversion and distribution but also need to provide structural support and environmental adaptability. However, deficiencies in strength, stiffness, or vibration characteristics may [...] Read more.
As a pivotal node in both urban and rural power grids, the box-type substation not only serves the functions of power conversion and distribution but also need to provide structural support and environmental adaptability. However, deficiencies in strength, stiffness, or vibration characteristics may lead to vibration and noise issues, and extreme environmental changes can pose risks of structural damage. This study aims to verify and optimize the seismic resistance and environmental adaptability of box-type substations through finite element simulation methods. Using SOLIDWORKS, a three-dimensional model of the box-type substation was constructed, and static and dynamic analyses were conducted using Ansys Workbench to comprehensively evaluate the dynamic response of the box-type substation under wind, snow loads, and seismic action. Through iterative simulations and a comparison of multiple design solutions, the structural optimization of the substation was achieved. The optimized structure balances strength and stiffness, significantly reducing the weight of the substation body, with the wall thickness reduced by 60%. Additionally, the phenomenon of stress concentration on the side walls was eliminated, ensuring that the equivalent stress is below the material yield strength. This research provides methods and empirical results for enhancing the performance and reliability of box-type substations under seismic conditions, confirming the feasibility of a lightweight design, while ensuring structural safety. Full article

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