The 2023 MDPI Annual Report has
been released!
 
20 pages, 2748 KiB  
Article
A Multidisciplinary Evaluation of Three-Dimensional Polycaprolactone Bioactive Glass Scaffolds for Bone Tissue Engineering Purposes
by Gregorio Marchiori, Devis Bellucci, Alessandro Gambardella, Mauro Petretta, Matteo Berni, Marco Boi, Brunella Grigolo, Gianluca Giavaresi, Nicola Baldini, Valeria Cannillo and Carola Cavallo
Materials 2024, 17(10), 2413; https://doi.org/10.3390/ma17102413 (registering DOI) - 17 May 2024
Abstract
In the development of bone graft substitutes, a fundamental step is the use of scaffolds with adequate composition and architecture capable of providing support in regenerative processes both on the tissue scale, where adequate resistance to mechanical stress is required, as well as [...] Read more.
In the development of bone graft substitutes, a fundamental step is the use of scaffolds with adequate composition and architecture capable of providing support in regenerative processes both on the tissue scale, where adequate resistance to mechanical stress is required, as well as at the cellular level where compliant chemical–physical and mechanical properties can promote cellular activity. In this study, based on a previous optimization study of this group, the potential of a three-dimensional construct based on polycaprolactone (PCL) and a novel biocompatible Mg- and Sr-containing glass named BGMS10 was explored. Fourier-transform infrared spectroscopy and scanning electron microscopy showed the inclusion of BGMS10 in the scaffold structure. Mesenchymal stem cells cultured on both PCL and PCL-BGMS10 showed similar tendencies in terms of osteogenic differentiation; however, no significant differences were found between the two scaffold types. This circumstance can be explained via X-ray microtomography and atomic force microscopy analyses, which correlated the spatial distribution of the BGMS10 within the bulk with the elastic properties and topography at the cell scale. In conclusion, our study highlights the importance of multidisciplinary approaches to understand the relationship between design parameters, material properties, and cellular response in polymer composites, which is crucial for the development and design of scaffolds for bone regeneration. Full article
14 pages, 524 KiB  
Article
Sedenion Algebra Model as an Extension of the Standard Model and Its Link to SU(5)
by Qiang Tang and Jau Tang
Symmetry 2024, 16(5), 626; https://doi.org/10.3390/sym16050626 (registering DOI) - 17 May 2024
Abstract
In the Standard Model, ad hoc hypotheses assume the existence of three generations of point-like leptons and quarks, which possess a point-like structure and follow the Dirac equation involving four anti-commutative matrices. In this work, we consider the sedenion hypercomplex algebra as an [...] Read more.
In the Standard Model, ad hoc hypotheses assume the existence of three generations of point-like leptons and quarks, which possess a point-like structure and follow the Dirac equation involving four anti-commutative matrices. In this work, we consider the sedenion hypercomplex algebra as an extension of the Standard Model and show its close link to SU(5), which is the underlying symmetry group for the grand unification theory (GUT). We first consider the direct-product quaternion model and the eight-element octonion algebra model. We show that neither the associative quaternion model nor the non-associative octonion model could generate three fermion generations. Instead, we show that the sedenion model, which contains three octonion sub-algebras, leads naturally to precisely three fermion generations. Moreover, we demonstrate the use of basis sedenion operators to construct twenty-four 5 × 5 generalized lambda matrices representing SU(5) generators, in analogy to the use of octonion basis operators to generate Gell-Mann’s eight 3 × 3 lambda-matrix generators for SU(3). Thus, we provide a link between the sedenion algebra and Georgi and Glashow’s SU(5) GUT model that unifies the electroweak and strong interactions for the Standard Model’s elementary particles, which obey SU(3)SU(2)U(1) symmetry. Full article
(This article belongs to the Special Issue Symmetry in Geometric Mechanics and Mathematical Physics)
12 pages, 728 KiB  
Article
Effects of Laser Scanning Strategy on Bending Behavior and Microstructure of DP980 Steel
by Wenbin Dong, Yajing Zhang, Le Bao and Kyoosik Shin
Materials 2024, 17(10), 2415; https://doi.org/10.3390/ma17102415 (registering DOI) - 17 May 2024
Abstract
Laser bending is a kind of cumulative forming technology and bending efficiency is one of its most important indexes. This study investigates the bending behavior and the microstructure of DP980 steel plates under different laser scanning strategies, using an IPG laser system. Two [...] Read more.
Laser bending is a kind of cumulative forming technology and bending efficiency is one of its most important indexes. This study investigates the bending behavior and the microstructure of DP980 steel plates under different laser scanning strategies, using an IPG laser system. Two sets of experiments varied the accumulated line energy density (AED) by altering the laser scanning velocity and number of scans. The results show that, for the single laser scanning process, the bending angle of the plate increases with AED, due to a larger temperature gradient through the thickness direction; however, this relationship is nonlinear. A higher AED led to a sharper initial increase in bending angle, which then plateaued. Under the same AED conditions, the bending angle of the plate undergoing multiple laser scans increases by at least 26% compared to the single one, due to the microstructure changes. It is revealed that the bending efficiency is affected by both the AED and the resultant microstructure evolution in the DP980 steel. Higher AED values and appropriate peak temperatures facilitate better bending behavior due to the formation of uniform martensite and grain refinement. Conversely, excessive peak temperatures can hinder bending due to grain growth. Full article
23 pages, 1336 KiB  
Article
A Transcriptomic Analysis Sheds Light on the Molecular Regulation of Wood Formation in Populus trichocarpa during Drought Stress
by Lijuan Dai, Bhavana Chaudhari, Tianyi Wang, Xiang Li, Dong Zeng, Chunming Li and Guanzheng Qu
Forests 2024, 15(5), 873; https://doi.org/10.3390/f15050873 (registering DOI) - 17 May 2024
Abstract
Wood is an abundant and essential renewable resource whose production is threatened in some parts of the world by drought. A better understanding of the molecular mechanisms underlying wood formation during drought is critical to maintaining wood production under increasingly adverse environmental conditions. [...] Read more.
Wood is an abundant and essential renewable resource whose production is threatened in some parts of the world by drought. A better understanding of the molecular mechanisms underlying wood formation during drought is critical to maintaining wood production under increasingly adverse environmental conditions. In this study, we investigated wood formation in black cottonwood (Populus trichocarpa) during drought stress. The morphological changes during drought stress in P. trichocarpa included the wilting and drooping of leaves, stem water loss, and a reduction in whole plant biomass. The water embolism rate indicated that the water transport in stems was blocked under drought conditions. An anatomical analysis of the xylem and cambium revealed that drought stress changed the structure of vessel cells, increased lignin accumulation, and decreased the cambium cell layers. We subsequently identified 12,438 and 9156 differentially expressed genes from stem xylem and cambium tissues under well-watered and drought conditions, respectively. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses revealed that these genes were mainly involved in hormone signal transduction and amino sugar and nucleotide sugar metabolism. To further explore the molecular mechanism of wood formation in response to drought, we analyzed the expression patterns of the genes involved in lignin, cellulose, and hemicellulose biosynthesis in xylem and the genes involved in cambial activity in the cambium. To better understand the regulatory networks governing xylem development and cambium activity in response to drought, we analyzed the MYB (138), AP2 (130), bHLH (89), and NAC (81) transcription factor families to shed light on the interactions between the TFs in these families and the genes they regulate. Identifying the key genes that regulate wood formation in P. trichocarpa during drought provides a genetic foundation for further research on the molecular regulatory networks and physiology underpinning wood formation during drought stress. Full article
(This article belongs to the Section Genetics and Molecular Biology)
40 pages, 1284 KiB  
Review
Cultural Competence Interventions in European Healthcare: A Scoping Review
by Berta De-María, Gabriela Topa and M. Angeles López-González
Healthcare 2024, 12(10), 1040; https://doi.org/10.3390/healthcare12101040 (registering DOI) - 17 May 2024
Abstract
Europe is undergoing rapid social change and is distinguished by its cultural superdiversity. Healthcare is facing an increasing need for professionals to adapt to this environment. Thus, the promotion of cultural competence in healthcare has become a priority. However, the training being developed [...] Read more.
Europe is undergoing rapid social change and is distinguished by its cultural superdiversity. Healthcare is facing an increasing need for professionals to adapt to this environment. Thus, the promotion of cultural competence in healthcare has become a priority. However, the training being developed and their suitability for the European context are not well known. The aim of this qualitative study has been to map the scientific literature in order to comprehend the current state of research on this topic. For this purpose, we conducted a systematic scoping review of the empirical publications focused on cultural competence interventions for healthcare professionals in European countries. The search was conducted in eight thematic (PsycINFO, MedLine, and PubPsych) and multidisciplinary databases (Academic Search Ultimate, E-Journals, Scopus, ProQuest, and Web of Science) to identify relevant publications up to 2023. Results were presented qualitatively. Out of the initial 6506 records screened, a total of 63 publications were included. Although the interventions were implemented in 23 different European countries, cultural competence interventions have not been widely adopted in Europe. Significant heterogeneity was observed in the conception and operacionalización of cultural competence models and in the implementation of the interventions. The interventions have mostly aimed at improving healthcare for minority population groups and have focused on the racial and ethnic dimensions of the individual. Future research is needed to contribute to the conceptual development of cultural competence to design programs tailored to European superdiversity. This scoping review has been registered in OSF and is available for consultation. Full article
17 pages, 2175 KiB  
Article
Use of the Sociogram in Participatory Planning in Contexts of Social Exclusion: A Comparative Case Study in Cordoba Neighbourhoods, Spain
by Antonio Delgado-Baena and Antonio Sianes
Land 2024, 13(5), 706; https://doi.org/10.3390/land13050706 (registering DOI) - 17 May 2024
Abstract
Urban regeneration and spatial planning have adopted a new participatory approach in recent decades, highlighting the importance of integrating the community in urban decision-making processes, especially in disadvantaged and socially excluded areas. In this context, the sociogram emerges as an essential tool for [...] Read more.
Urban regeneration and spatial planning have adopted a new participatory approach in recent decades, highlighting the importance of integrating the community in urban decision-making processes, especially in disadvantaged and socially excluded areas. In this context, the sociogram emerges as an essential tool for collaborative governance, allowing the visualization and analysis of the dynamics between the different actors involved. This study employs a comparative case study approach in three disadvantaged neighbourhoods in Córdoba, Spain, to examine how the sociogram can facilitate more effective and democratic participation in urban planning. Using heat maps, scatter plots and average analysis, relationships between actors are identified and characterized, providing a solid basis for more inclusive and equitable planning decisions. This analysis not only reveals the practical utility of the sociogram in participatory research but also underscores its theoretical relevance in building resilient and cohesive communities. Findings confirm the sociogram’s effectiveness in mapping stakeholder dynamics and enhancing participatory governance, ultimately fostering more informed and inclusive urban planning processes. Full article
(This article belongs to the Special Issue Participatory Land Planning: Theory, Methods, and Case Studies)
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38 pages, 522 KiB  
Article
Static Spherically Symmetric Perfect Fluid Solutions in Teleparallel F(T) Gravity
by Alexandre Landry
Axioms 2024, 13(5), 333; https://doi.org/10.3390/axioms13050333 (registering DOI) - 17 May 2024
Abstract
In this paper, we investigate static spherically symmetric teleparallel F(T) gravity containing a perfect isotropic fluid. We first write the field equations and proceed to find new teleparallel F(T) solutions for perfect isotropic and linear fluids. By [...] Read more.
In this paper, we investigate static spherically symmetric teleparallel F(T) gravity containing a perfect isotropic fluid. We first write the field equations and proceed to find new teleparallel F(T) solutions for perfect isotropic and linear fluids. By using a power-law ansatz for the coframe components, we find several classes of new non-trivial teleparallel F(T) solutions. We also find a new class of teleparallel F(T) solutions for a matter dust fluid. After, we solve the field equations for a non-linear perfect fluid. Once again, there are several new exact teleparallel F(T) solutions and also some approximated teleparallel F(T) solutions. All these classes of new solutions may be relevant for future cosmological and astrophysical applications. Full article
(This article belongs to the Special Issue Advances in Differential Geometry and Mathematical Physics)
15 pages, 2524 KiB  
Article
Jasmonates Play an Important Role in Differential Accumulation of Key Oolong Tea Aromas in Two Tea Varieties (Camellia sinensis)
by Xin-Lei Li, Hui-Li Deng, Yu-Cheng Zheng, Xiang-Rui Kong, Qiu-Sheng Zhong, Xiao-Mei You, Rui-Yang Shan, Zheng-He Lin, Zhi-Hui Chen and Chang-Song Chen
Horticulturae 2024, 10(5), 520; https://doi.org/10.3390/horticulturae10050520 (registering DOI) - 17 May 2024
Abstract
Aroma is an important factor in the measurement of the quality and market value of oolong tea. However, it is hard to develop an oolong tea with good aroma quality using unsuitable tea varieties. To explore the key factors of tea varieties in [...] Read more.
Aroma is an important factor in the measurement of the quality and market value of oolong tea. However, it is hard to develop an oolong tea with good aroma quality using unsuitable tea varieties. To explore the key factors of tea varieties in the formation of oolong tea aromas, the fresh leaves of the Chungui variety (CG, suitable for oolong tea, Camellia sinensis (L.) O. Kuntze) and the Fuyun No. 6 variety (F6, unsuitable for oolong tea, Camellia sinensis (L.) O. Kuntze) were harvested and treated by withering and mechanical stress in order. Then, aroma, transcriptome, and jasmonate (JA) contents, and weighted gene co-expression network analysis (WGCNA), of samples were investigated. The contents of characteristic oolong tea aromas, including indole, (E)-β-ocimene, (E)-nerolidol, α-farnesene, and jasmine lactone, were all accumulated in much higher quantities in the CG variety after withering and mechanical stress. Accordingly, the coding genes of aroma formation synthases TSB2, OCS, NES, AFS, and LOX1, and related genes in MVA, MEP, and ALA pathways, were all much more highly activated. These differential reactions are mainly caused by the higher accumulation of jasmonates, especially methyl jasmonate, a type of important plant signal chemical, in CG after mechanical stress. WGCNA analysis indicated 34 different transcription factors from different families are predicted to be involved in this jasmonate-responsive reaction. Full article
(This article belongs to the Section Medicinals, Herbs, and Specialty Crops)
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23 pages, 1208 KiB  
Review
Intraoperative Neurophysiological Monitoring in Neurosurgery
by Giusy Guzzi, Riccardo Antonio Ricciuti, Attilio Della Torre, Erica Lo Turco, Angelo Lavano, Federico Longhini and Domenico La Torre
J. Clin. Med. 2024, 13(10), 2966; https://doi.org/10.3390/jcm13102966 (registering DOI) - 17 May 2024
Abstract
Intraoperative neurophysiological monitoring (IONM) is a crucial advancement in neurosurgery, enhancing procedural safety and precision. This technique involves continuous real-time assessment of neurophysiological signals, aiding surgeons in timely interventions to protect neural structures. In addition to inherent limitations, IONM necessitates a detailed anesthetic [...] Read more.
Intraoperative neurophysiological monitoring (IONM) is a crucial advancement in neurosurgery, enhancing procedural safety and precision. This technique involves continuous real-time assessment of neurophysiological signals, aiding surgeons in timely interventions to protect neural structures. In addition to inherent limitations, IONM necessitates a detailed anesthetic plan for accurate signal recording. Given the growing importance of IONM in neurosurgery, we conducted a narrative review including the most relevant studies about the modalities and their application in different fields of neurosurgery. In particular, this review provides insights for all physicians and healthcare professionals unfamiliar with IONM, elucidating commonly used techniques in neurosurgery. In particular, it discusses the roles of IONM in various neurosurgical settings such as tumoral brain resection, neurovascular surgery, epilepsy surgery, spinal surgery, and peripheral nerve surgery. Furthermore, it offers an overview of the anesthesiologic strategies and limitations of techniques essential for the effective implementation of IONM. Full article
(This article belongs to the Section Clinical Neurology)
14 pages, 534 KiB  
Article
Sex Pheromone Receptor Ste2 Orchestrates Chemotropic Growth towards Pine Root Extracts in the Pitch Canker Pathogen Fusarium circinatum
by Jane B. Ramaswe, Emma T. Steenkamp, Lieschen De Vos, Felix F. Fru, Omotayo O. Adegeye and Brenda D. Wingfield
Pathogens 2024, 13(5), 425; https://doi.org/10.3390/pathogens13050425 (registering DOI) - 17 May 2024
Abstract
In ascomycetous fungi, sexual mate recognition requires interaction of the Ste2 receptor protein produced by one partner with the α-factor peptide pheromone produced by the other partner. In some fungi, Ste2 is further needed for chemotropism towards plant roots to allow for subsequent [...] Read more.
In ascomycetous fungi, sexual mate recognition requires interaction of the Ste2 receptor protein produced by one partner with the α-factor peptide pheromone produced by the other partner. In some fungi, Ste2 is further needed for chemotropism towards plant roots to allow for subsequent infection and colonization. Here, we investigated whether this is also true for the pine pitch canker fungus, Fusarium circinatum, which is a devastating pathogen of pine globally. Ste2 knockout mutants were generated for two opposite mating-type isolates, after which all strains were subjected to chemotropism assays involving exudates from pine seedling roots and synthetic α-factor pheromone, as well as a range of other compounds for comparison. Our data show that Ste2 is not required for chemotropism towards any of these other compounds, but, in both wild-type strains, Ste2 deletion resulted in the loss of chemotropism towards pine root exudate. Also, irrespective of mating type, both wild-type strains displayed positive chemotropism towards α-factor pheromone, which was substantially reduced in the deletion mutants and not the complementation mutants. Taken together, these findings suggest that Ste2 likely has a key role during the infection of pine roots in production nurseries. Our study also provides a strong foundation for exploring the role of self-produced and mate-produced α-factor pheromone in the growth and overall biology of the pitch canker pathogen. Full article
(This article belongs to the Special Issue Fungal Pathogens of Crops)
12 pages, 37783 KiB  
Article
Microscopic Image Dataset with Segmentation and Detection Labels for Microplastic Analysis in Sewage: Enhancing Research and Environmental Monitoring
by Gwanghee Lee, Jaeheon Jung, Sangjun Moon, Jihyun Jung and Kyoungson Jhang
Microplastics 2024, 3(2), 264-275; https://doi.org/10.3390/microplastics3020016 (registering DOI) - 17 May 2024
Abstract
We introduce a novel microscopic image dataset augmented with segmentation and detection labels specifically designed for microplastic analysis in sewage environments. Recognizing the increasing concern over microplastics—particles of synthetic polymers smaller than 5 mm—and their detrimental effects on marine ecosystems and human health, [...] Read more.
We introduce a novel microscopic image dataset augmented with segmentation and detection labels specifically designed for microplastic analysis in sewage environments. Recognizing the increasing concern over microplastics—particles of synthetic polymers smaller than 5 mm—and their detrimental effects on marine ecosystems and human health, our research focuses on enhancing detection and analytical methodologies through advanced computer vision and deep learning techniques. The dataset comprises high-resolution microscopic images of microplastics collected from sewage, meticulously labeled for both segmentation and detection tasks, aiming to facilitate accurate and efficient identification and quantification of microplastic pollution. In addition to dataset development, we present example deep learning models optimized for segmentation and detection of microplastics within complex sewage samples. The models demonstrate significant potential in automating the analysis of microplastic contamination, offering a scalable solution to environmental monitoring challenges. Furthermore, we ensure the accessibility and reproducibility 12 of our research by making the dataset and model codes publicly available, accompanied by detailed 13 documentation on GitHub and LabelBox. Full article
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24 pages, 9936 KiB  
Article
Carbon Emissions and Vegetation Dynamics: Assessing the Spatiotemporal Environmental Impacts of Hydropower Dams in the Lancang River Basin
by Yu Liu, Xiaomao Wang, Gang Ma, Wei Zhou and Xiang Cheng
Forests 2024, 15(5), 872; https://doi.org/10.3390/f15050872 (registering DOI) - 17 May 2024
Abstract
Recent decades in the Lancang River Basin have witnessed extensive construction of hydropower dams, profoundly impacting the local environment. Utilizing high-precision satellite data, we conducted a comprehensive analysis of vegetation cover and carbon emissions, integrating data-driven time series and spatial analysis models to [...] Read more.
Recent decades in the Lancang River Basin have witnessed extensive construction of hydropower dams, profoundly impacting the local environment. Utilizing high-precision satellite data, we conducted a comprehensive analysis of vegetation cover and carbon emissions, integrating data-driven time series and spatial analysis models to capture both temporal and spatial dynamics. Our findings reveal that hydropower dam construction in the Lancang River Basin has significantly promoted vegetation restoration and growth, concurrently facilitating a reduction in regional carbon emissions. Employing deep learning models for time-series prediction, we observed a substantial increase in the sum of the local normalized difference vegetation index (NDVI) post-construction, with an average rise of from 16.15% to a maximum of 20.12% during the pivotal hydropower dams’ operational phase. Between 2001 and 2020, the construction of hydropower dams in the basin corresponded to notable changes in ecological and carbon metrics. Specifically, vegetation cover expansion intensity (VCEI) reversed from a negative mean of −0.009 to a positive mean of 0.008. Additionally, the carbon emission intensity (CEI) around these dams drastically reduced, shifting from an average of 0.877 to 0.052. Importantly, the Global Moran’s I for VCEI significantly increased from 0.288 pre-2016 to 0.679 post-2015, reflecting a stronger spatial autocorrelation in vegetation patterns. Accordingly, these findings illustrate the complex interplay between hydropower dams and environmental outcomes, underscoring the critical role of pivotal hydropower dam construction in ecological improvement. The research results have improved and complemented those of previous studies on the environmental impact of hydraulic engineering, providing valuable insights for the construction management and policy formulation of hydropower dams in other similar river basins around the world. Full article
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23 pages, 5265 KiB  
Article
LEO-Enhanced GNSS/INS Tightly Coupled Integration Based on Factor Graph Optimization in the Urban Environment
by Shixuan Zhang, Rui Tu, Zhouzheng Gao, Decai Zou, Siyao Wang and Xiaochun Lu
Remote Sens. 2024, 16(10), 1782; https://doi.org/10.3390/rs16101782 (registering DOI) - 17 May 2024
Abstract
Precision point positioning (PPP) utilizing the Global Navigation Satellite System (GNSS) is a traditional and widely employed technology. Its performance is susceptible to observation discontinuities and unfavorable geometric configurations. Consequently, the integration of the Inertial Navigation System (INS) and GNSS makes full use [...] Read more.
Precision point positioning (PPP) utilizing the Global Navigation Satellite System (GNSS) is a traditional and widely employed technology. Its performance is susceptible to observation discontinuities and unfavorable geometric configurations. Consequently, the integration of the Inertial Navigation System (INS) and GNSS makes full use of their respective advantages and effectively mitigates the limitations of GNSS positioning. However, the GNSS/INS integration faces significant challenges in complex and harsh urban environments. In recent years, the geometry between the user and the satellite has been effectively improved with the advent of lower-orbits and faster-speed Low Earth Orbit (LEO) satellites. This enhancement provides more observation data, opening up new possibilities and opportunities for high-precision positioning. Meanwhile, in contrast to the traditional extended Kalman filter (EKF) approach, the performance of the LEO-enhanced GNSS/INS tightly coupled integration (TCI) can be significantly improved by employing the factor graph optimization (FGO) method with multiple iterations to achieve stable estimation. In this study, LEO data and the FGO method were employed to enhance the GNSS/INS TCI. To validate the effectiveness of the method, vehicle data and simulated LEO observations were subjected to thorough analysis. The results suggest that the integration of LEO data significantly enhances the positioning accuracy and convergence speed of the GNSS/INS TCI. In contrast to the FGO GNSS/INS TCI without LEO enhancement, the average enhancement effect of the LEO is 22.16%, 7.58%, and 10.13% in the north, east, and vertical directions, respectively. Furthermore, the average root mean square error (RMSE) of the LEO-enhanced FGO GNSS/INS TCI is 0.63 m, 1.21 m, and 0.85 m in the north, east, and vertical directions, respectively, representing an average improvement of 41.91%, 13.66%, and 2.52% over the traditional EKF method. Meanwhile, the simulation results demonstrate that LEO data and the FGO method effectively enhance the positioning and convergence performance of GNSS/INS TCI in GNSS-challenged environments (tall buildings, viaducts, underground tunnels, and wooded areas). Full article
14 pages, 1732 KiB  
Article
A Comparative Study of Composition and Soluble Polysaccharide Content between Brewer’s Spent Yeast and Cultured Yeast Cells
by Hyun Ji Lee, Bo-Ram Park and Legesse Shiferaw Chewaka
Foods 2024, 13(10), 1567; https://doi.org/10.3390/foods13101567 (registering DOI) - 17 May 2024
Abstract
Yeast, crucial in beer production, holds great potential owing - to its ability to transform into a valuable by-product resource, known as brewer’s spent yeast (BSY), with potentially beneficial physiological effects. This study aimed to compare the composition and soluble polysaccharide content of [...] Read more.
Yeast, crucial in beer production, holds great potential owing - to its ability to transform into a valuable by-product resource, known as brewer’s spent yeast (BSY), with potentially beneficial physiological effects. This study aimed to compare the composition and soluble polysaccharide content of Brewer’s spent yeast with those of cultured yeast strains, namely Saccharomyces cerevisiae (SC) and S. boulardii (SB), to facilitate the utilization of BSY as an alternative source of functional polysaccharides. BSY exhibited significantly higher carbohydrate content and lower crude protein content than SC and SB cells. The residues recovered through autolysis were 53.11%, 43.83%, and 44.99% for BSY, SC, and SB, respectively. Notably, the polysaccharide content of the BSY residue (641.90 μg/mg) was higher than that of SC (553.52 μg/mg) and SB (591.56 μg/mg). The yields of alkali-extracted water-soluble polysaccharides were 33.62%, 40.76%, and 42.97% for BSY, SC, and SB, respectively, with BSY comprising a comparable proportion of water-soluble saccharides made with SC and SB, including 49.31% mannan and 20.18% β-glucan. Furthermore, BSY demonstrated antioxidant activities, including superoxide dismutase (SOD), ABTS, and DPPH scavenging potential, suggesting its ability to mitigate oxidative stress. BSY also exhibited a significantly higher total phenolic compound content, indicating its potential to act as an effective functional food material. Full article
(This article belongs to the Section Food Biotechnology)
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21 pages, 1561 KiB  
Article
A High-Resolution Time Reversal Method for Target Localization in Reverberant Environments
by Huiying Ma, Tao Shang, Gufeng Li and Zhaokun Li
Sensors 2024, 24(10), 3196; https://doi.org/10.3390/s24103196 (registering DOI) - 17 May 2024
Abstract
Reverberation in real environments is an important factor affecting the high resolution of target sound source localization (SSL) methods. Broadband low-frequency signals are common in real environments. This study focuses on the localization of this type of signal in reverberant environments. Because the [...] Read more.
Reverberation in real environments is an important factor affecting the high resolution of target sound source localization (SSL) methods. Broadband low-frequency signals are common in real environments. This study focuses on the localization of this type of signal in reverberant environments. Because the time reversal (TR) method can overcome multipath effects and realize adaptive focusing, it is particularly suitable for SSL in a reverberant environment. On the basis of the significant advantages of the sparse Bayesian learning algorithm in the estimation of wave direction, a novel SSL is proposed in reverberant environments. First, the sound propagation model in a reverberant environment is studied and the TR focusing signal is obtained. We then use the sparse Bayesian framework to locate the broadband low-frequency sound source. To validate the effectiveness of the proposed method for broadband low-frequency targeting in a reverberant environment, simulations and real data experiments were performed. The localization performance under different bandwidths, different numbers of microphones, signal-to-noise ratios, reverberation times, and off-grid conditions was studied in the simulation experiments. The practical experiment was conducted in a reverberation chamber. Simulation and experimental results indicate that the proposed method can achieve satisfactory spatial resolution in reverberant environments and is robust. Full article
(This article belongs to the Collection Sensors and Systems for Indoor Positioning)
20 pages, 760 KiB  
Article
Impact of Reward Mechanisms on Consumers’ Willingness to Use Intelligent Express Packaging Recycling Cabinets: A Case Study in China
by Ying Zhan, Yue Sun and Junfei Xu
Sustainability 2024, 16(10), 4225; https://doi.org/10.3390/su16104225 (registering DOI) - 17 May 2024
Abstract
The use of express packaging and its recycling produces large amounts of carbon dioxide. In order to achieve China’s “dual carbon” goal, this study adopted a literature research method to explore the idea of intelligent express packaging recycling cabinets. Based on the current [...] Read more.
The use of express packaging and its recycling produces large amounts of carbon dioxide. In order to achieve China’s “dual carbon” goal, this study adopted a literature research method to explore the idea of intelligent express packaging recycling cabinets. Based on the current design and use of intelligent express packaging recycling cabinets, new ideas for their improvement are proposed. This study also explored methods for improving people’s willingness to use intelligent express packaging recycling cabinets through experimental research and quantitative analysis. The results show that a reward mechanism has a significant effect on people’s willingness to use intelligent express packaging recycling cabinets. Of the two types of rewards, immediate rewards, compared to delayed rewards, can further increase people’s use of intelligent express packaging recycling cabinets. Gain and loss trade-offs play a mediating role between a reward mechanism and people’s willingness to use it, and consumers make that choice after weighing up the advantages and disadvantages. If consumers feel that it is worthwhile to protect the environment, in terms of the rewards they obtain compared to the time and effort they have to spend using intelligent express packaging recycling cabinets, and that the gain outweighs the loss, they will be inclined to use this system. Environmental responsibility plays a moderating role in mediating the trade-off between gains and losses. In the context of low environmental responsibility, cash rewards lead to greater gain and loss trade-offs compared to point rewards, while in the context of high environmental responsibility, there is no difference between cash rewards and point rewards. This study provides ideas for the design and promotion of the use of intelligent express packaging recycling cabinets, with the goal of effectively improving the recycling rate of express packaging waste. Full article
27 pages, 2283 KiB  
Article
Prioritizing Environmental Attributes to Enhance Residents’ Satisfaction in Post-Industrial Neighborhoods: An Application of Machine Learning-Augmented Asymmetric Impact-Performance Analysis
by Xian Ji, Furui Shang, Chang Liu, Qinggong Kang, Rui Wang and Chenxi Dou
Sustainability 2024, 16(10), 4224; https://doi.org/10.3390/su16104224 (registering DOI) - 17 May 2024
Abstract
Post-industrial neighborhoods are valued for their historical and cultural significance but often contend with challenges such as physical deterioration, social instability, and cultural decay, which diminish residents’ satisfaction. Leveraging urban renewal as a catalyst, it is essential to boost residents’ satisfaction by enhancing [...] Read more.
Post-industrial neighborhoods are valued for their historical and cultural significance but often contend with challenges such as physical deterioration, social instability, and cultural decay, which diminish residents’ satisfaction. Leveraging urban renewal as a catalyst, it is essential to boost residents’ satisfaction by enhancing the environmental quality of these areas. This study, drawing on data from Shenyang, China, utilizes the combined strengths of gradient boosting decision trees (GBDTs) and asymmetric impact-performance analysis (AIPA) to systematically identify and prioritize the built-environment attributes that significantly enhance residents’ satisfaction. Our analysis identifies twelve key attributes, strategically prioritized based on their asymmetric impacts on satisfaction and current performance levels. Heritage maintenance, property management, activities, and heritage publicity are marked as requiring immediate improvement, with heritage maintenance identified as the most urgent. Other attributes are categorized based on their potential to enhance satisfaction or their lack of immediate improvement needs, enabling targeted and effective urban revitalization strategies. This research equips urban planners and policymakers with critical insights, supporting informed decisions that markedly improve the quality of life in these distinctive urban settings. Full article
(This article belongs to the Special Issue Sustainable Conservation of Urban and Cultural Heritage)
17 pages, 1103 KiB  
Article
Developing a Tool for Assessing the Process of Seeking Health Information: Online Think-Aloud Method
by Asim Alhejaili, Heather Wharrad and Richard Windle
Healthcare 2024, 12(10), 1039; https://doi.org/10.3390/healthcare12101039 (registering DOI) - 17 May 2024
Abstract
Nursing students can access massive amounts of online health data to drive cutting-edge evidence-based practice in clinical placement, to bridge the theory–practice gap. This activity requires investigation to identify the strategies nursing students apply to evaluate online health information. Online Think-Aloud sessions enabled [...] Read more.
Nursing students can access massive amounts of online health data to drive cutting-edge evidence-based practice in clinical placement, to bridge the theory–practice gap. This activity requires investigation to identify the strategies nursing students apply to evaluate online health information. Online Think-Aloud sessions enabled 14 participants to express their cognitive processes in navigating various educational resources, including online journals and databases, and determining the reliability of sources, indicating their strategies for information-seeking, which helped to create this scoring system. Easy access and user convenience were clearly the instrumental factors in this behavior, which has troubling implications for the lack of use of higher-quality resources (e.g., from peer-reviewed academic journals). The identified challenges encountered during resource access included limited skills in the critical evaluation of information credibility and reliability, signaling a requirement for improved information literacy skills. Participants acknowledged the importance of evidence-based, high-quality information, but faced numerous barriers, such as restricted access to professional and specialty databases, and a lack of academic skills training. This paper develops and critiques a Performative Tool for assessing the process of seeking health information using an online Think-Aloud method, and explores factors and strategies contributing to evidence-based health information access and utilization in clinical practice, aiming to provide insight into individuals’ information-seeking behaviors in online health contexts. Full article
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29 pages, 5510 KiB  
Article
Impact of Aerosols on the Macrophysical and Microphysical Characteristics of Ice-Phase and Mixed-Phase Clouds over the Tibetan Plateau
by Shizhen Zhu, Ling Qian, Xueqian Ma, Yujun Qiu, Jing Yang, Xin He, Junjun Li, Lei Zhu, Jing Gong and Chunsong Lu
Remote Sens. 2024, 16(10), 1781; https://doi.org/10.3390/rs16101781 (registering DOI) - 17 May 2024
Abstract
Using CloudSat/CALIPSO satellite data and ERA5 reanalysis data from 2006 to 2010, the effects of aerosols on ice- and mixed-phase, single-layer, non-precipitating clouds over the Tibetan Plateau during nighttime in the MAM (March to May), JJA (June to August), SON (September to November), [...] Read more.
Using CloudSat/CALIPSO satellite data and ERA5 reanalysis data from 2006 to 2010, the effects of aerosols on ice- and mixed-phase, single-layer, non-precipitating clouds over the Tibetan Plateau during nighttime in the MAM (March to May), JJA (June to August), SON (September to November), and DJF (December to February) seasons were examined. The results indicated the following: (1) The macrophysical and microphysical characteristics of ice- and mixed-phase clouds exhibit a nonlinear trend with increasing aerosol optical depth (AOD). When the logarithm of AOD (lnAOD) was ≤−4.0, with increasing AOD during MAM and JJA nights, the cloud thickness and ice particle effective radius of ice-phase clouds and mixed-phase clouds, the ice water path and ice particle number concentration of ice-phase clouds, and the liquid water path and cloud fraction of mixed-phase clouds all decreased; during SON and DJF nights, the cloud thickness of ice-phase clouds, cloud top height, liquid droplet number concentration, and liquid water path of mixed-phase clouds all decreased. When the lnAOD was > −4.0, with increasing AOD during MAM and JJA nights, the cloud top height, cloud base height, cloud fraction, and ice particle number concentration of ice-phase clouds, and the ice water path of mixed-phase clouds all increased; during SON and DJF nights, the cloud fraction of mixed-phase clouds and the ice water path of ice-phase clouds all increased. (2) Under the condition of excluding meteorological factors, including the U-component of wind, V-component of wind, pressure vertical velocity, temperature, and relative humidity at the atmospheric pressure heights near the average cloud top height, within the cloud, and the average cloud base height, as well as precipitable water vapor, convective available potential energy, and surface pressure. During MAM and JJA nights. When the lnAOD was ≤ −4.0, an increase in aerosols may have led to a decrease in the thickness of ice and mixed-phase cloud layers, as well as a reduction in cloud water path values. In contrast, when the lnAOD was > −4.0, an increase in aerosols may contribute to elevated cloud base and cloud top heights for ice-phase clouds. During SON and DJF nights, changes in various cloud characteristics may be influenced by both aerosols and meteorological factors. Full article
(This article belongs to the Special Issue Remote Sensing of Aerosols, Planetary Boundary Layer, and Clouds)
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13 pages, 7917 KiB  
Article
Research on Laser Cleaning Technology for Aircraft Skin Surface Paint Layer
by Jinxuan Li, Jianjun Yang, Jiaxuan Liu, Hui Chen, Yunfei Duan and Xinjian Pan
Materials 2024, 17(10), 2414; https://doi.org/10.3390/ma17102414 (registering DOI) - 17 May 2024
Abstract
In this study, a pulsed laser operating at a wavelength of 1064 nm and with a pulse width of 100 ns was utilized for the removal of paint from the surface of a 2024 aluminum alloy. The experimental investigation was conducted to analyze [...] Read more.
In this study, a pulsed laser operating at a wavelength of 1064 nm and with a pulse width of 100 ns was utilized for the removal of paint from the surface of a 2024 aluminum alloy. The experimental investigation was conducted to analyze the influence of laser parameters on the efficacy of paint layer removal from the aircraft skin’s surface and the subsequent evolution in the microstructure of the laser-treated aluminum alloy substrate. The mechanism underlying laser cleaning was explored through simulation. The findings revealed that power density and scanning speed significantly affected the quality of cleaning. Notably, there were discernible damage thresholds and optimal cleaning parameters in repetitive frequency, with a power density of 178.25 MW/cm2, scanning speed of 500 mm/s, and repetitive frequency of 40 kHz identified as the primary optimal settings for achieving the desired cleaning effect. Thermal ablation and thermal vibration were identified as the principal mechanisms of cleaning. Moreover, laser processing induced surface dislocations and concentrated stress, accompanied by grain refinement, on the aluminum substrate. Full article
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17 pages, 2021 KiB  
Article
Design and Characterisation of a Read-Out System for Wireless Monitoring of a Novel Implantable Sensor for Abdominal Aortic Aneurysm Monitoring
by Nuno P. Silva, Adnan Elahi, Eoghan Dunne, Martin O’Halloran and Bilal Amin
Sensors 2024, 24(10), 3195; https://doi.org/10.3390/s24103195 (registering DOI) - 17 May 2024
Abstract
Abdominal aortic aneurysm (AAA) is a dilation of the aorta artery larger than its normal diameter (>3 cm). Endovascular aneurysm repair (EVAR) is a minimally invasive treatment option that involves the placement of a graft in the aneurysmal portion of the aorta artery. [...] Read more.
Abdominal aortic aneurysm (AAA) is a dilation of the aorta artery larger than its normal diameter (>3 cm). Endovascular aneurysm repair (EVAR) is a minimally invasive treatment option that involves the placement of a graft in the aneurysmal portion of the aorta artery. This treatment requires multiple follow-ups with medical imaging, which is expensive, time-consuming, and resource-demanding for healthcare systems. An alternative solution is the use of wireless implantable sensors (WIMSs) to monitor the growth of the aneurysm. A WIMS capable of monitoring aneurysm size longitudinally could serve as an alternative monitoring approach for post-EVAR patients. This study has developed and characterised a three-coil inductive read-out system to detect variations in the resonance frequency of the novel Z-shaped WIMS implanted within the AAA sac. Specifically, the spacing between the transmitter and the repeater inductors was optimised to maximise the detection of the sensor by the transmitter inductor. Moreover, an experimental evaluation was also performed for different orientations of the transmitter coil with reference to the WIMS. Finally, the FDA-approved material nitinol was used to develop the WIMS, the transmitter, and repeater inductors as a proof of concept for further studies. The findings of the characterisation from the air medium suggest that the read-out system can detect the WIMS up to 5 cm, regardless of the orientation of the Z-shape WIMS, with the detection range increasing as the orientation approaches 0°. This study provides sufficient evidence that the proposed WIMS and the read-out system can be used for AAA expansion over time. Full article
(This article belongs to the Special Issue Advances in Magnetic Sensors and Their Applications)
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13 pages, 1255 KiB  
Article
Snapshot of Anti-SARS-CoV-2 IgG Antibodies in COVID-19 Recovered Patients in Guinea
by Solène Grayo, Houlou Sagno, Oumar Diassy, Jean-Baptiste Zogbelemou, Sia Jeanne Kondabo, Marilyn Houndekon, Koussay Dellagi, Inès Vigan-Womas, Samia Rourou, Wafa Ben Hamouda, Chaouki Benabdessalem, Melika Ben Ahmed and Noël Tordo
J. Clin. Med. 2024, 13(10), 2965; https://doi.org/10.3390/jcm13102965 (registering DOI) - 17 May 2024
Abstract
Background: Because the regular vaccine campaign started in Guinea one year after the COVID-19 index case, the profile of naturally acquired immunity following primary SARS-CoV-2 infection needs to be deepened. Methods: Blood samples were collected once from 200 patients (90% of African [...] Read more.
Background: Because the regular vaccine campaign started in Guinea one year after the COVID-19 index case, the profile of naturally acquired immunity following primary SARS-CoV-2 infection needs to be deepened. Methods: Blood samples were collected once from 200 patients (90% of African extraction) who were recovered from COVID-19 for at least ~2.4 months (72 days), and their sera were tested for IgG antibodies to SARS-CoV-2 using an in-house ELISA assay against the Receptor Binding Domain (RBD) of the SARS-CoV-2 spike1 protein (RBD/S1-IH kit). Results: Results revealed that 73% of sera (146/200) were positive for IgG to SARS-CoV-2 with an Optical Density (OD) ranging from 0.13 to 1.19 and a median value of 0.56 (IC95: 0.51–0.61). The median OD value at 3 months (1.040) suddenly decreased thereafter and remained stable around OD 0.5 until 15 months post-infection. The OD median value was slightly higher in males compared to females (0.62 vs. 0.49), but the difference was not statistically significant (p-value: 0.073). In contrast, the OD median value was significantly higher among the 60–100 age group (0.87) compared to other groups, with a noteworthy odds ratio compared to the 0–20 age group (OR: 9.69, p-value: 0.044*). Results from the RBD/S1-IH ELISA kit demonstrated superior concordance with the whole spike1 protein ELISA commercial kit compared to a nucleoprotein ELISA commercial kit. Furthermore, anti-spike1 protein ELISAs (whole spike1 and RBD/S1) revealed higher seropositivity rates. Conclusions: These findings underscore the necessity for additional insights into naturally acquired immunity against COVID-19 and emphasize the relevance of specific ELISA kits for accurate seropositivity rates. Full article
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26 pages, 1211 KiB  
Article
A Multiphysics Thermoelastoviscoplastic Damage Internal State Variable Constitutive Model including Magnetism
by M. Malki, M. F. Horstemeyer, H. E. Cho, L. A. Peterson, D. Dickel, L. Capolungo and M. I. Baskes
Materials 2024, 17(10), 2412; https://doi.org/10.3390/ma17102412 (registering DOI) - 17 May 2024
Abstract
We present a macroscale constitutive model that couples magnetism with thermal, elastic, plastic, and damage effects in an Internal State Variable (ISV) theory. Previous constitutive models did not include an interdependence between the internal magnetic (magnetostriction and magnetic flux) and mechanical fields. Although [...] Read more.
We present a macroscale constitutive model that couples magnetism with thermal, elastic, plastic, and damage effects in an Internal State Variable (ISV) theory. Previous constitutive models did not include an interdependence between the internal magnetic (magnetostriction and magnetic flux) and mechanical fields. Although constitutive models explaining the mechanisms behind mechanical deformations caused by magnetization changes have been presented in the literature, they mainly focus on nanoscale structure–property relations. A fully coupled multiphysics macroscale ISV model presented herein admits lower length scale information from the nanoscale and microscale descriptions of the multiphysics behavior, thus capturing the effects of magnetic field forces with isotropic and anisotropic magnetization terms and moments under thermomechanical deformations. For the first time, this ISV modeling framework internally coheres to the kinematic, thermodynamic, and kinetic relationships of deformation using the evolving ISV histories. For the kinematics, a multiplicative decomposition of deformation gradient is employed including a magnetization term; hence, the Jacobian represents the conservation of mass and conservation of momentum including magnetism. The first and second laws of thermodynamics are used to constrain the appropriate constitutive relations through the Clausius–Duhem inequality. The kinetic framework employs a stress–strain relationship with a flow rule that couples the thermal, mechanical, and magnetic terms. Experimental data from the literature for three different materials (iron, nickel, and cobalt) are used to compare with the model’s results showing good correlations. Full article

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