A SiC fin-channel MOSFET structure (Fin-MOS) is proposed for an enhanced gate shielding effect. The gates are placed on each side of the narrow fin-channel region, while grounded p-shield regions below the gates provide a strong shielding effect. The device is investigated using Sentaurus TCAD. For a narrow fin-channel region, there is difficulty in forming an Ohmic contact to the p-base; a floating p-base might potentially store negative charges upon high drain voltage, and, thus, causes threshold voltage instabilities. The simulation reveals that, for a fin-width of 0.2 μm, the p-shield regions provide a stringent shielding effect against high drain voltage, and the dynamic threshold voltage shift (∆V_th) is negligible. Compared to conventional trench MOSFET (Trench-MOS) and asymmetric trench MOSFET (Asym-MOS), the proposed Fin-MOS boasts the lowest OFF-state oxide field and reverse transfer capacitance (C_rss), while maintaining a similar low ON-resistance. Full article

To enhance the resistant starch (RS) content of corn starch, in this work, carboxymethyl chitosan/corn starch/sodium alginate microcapsules (CMCS/CS/SA) with varying concentrations of SA in a citric acid (CA) solution were designed. As the SA concentration increased from 0.5% to 2%, the swelling of the CMCS/CS/SA microcapsule decreased from 15.28 ± 0.21 g/g to 3.76 ± 0.66 g/g at 95 °C. Comparatively, the onset, peak, and conclusion temperatures (T_o, T_p, and T_c) of CMCS/CS/SA microcapsules were higher than those of unencapsulated CS, indicating that the dense network structure of microcapsules reduced the contact area between starch granules and water, thereby improving thermal stability. With increasing SA concentration, the intact and dense network of CMCS/CS/SA microcapsules remained less damaged after 120 min of digestion, suggesting that the microcapsules with a high SA concentration provided better protection to starch, thereby reducing amylase digestibility. Moreover, as the SA concentration increased from 0.5% to 2%, the RS content of the microcapsules during in vitro digestion rose from 42.37 ± 0.07% to 57.65 ± 0.45%, attributed to the blocking effect of the microcapsule shell on amylase activity. This study offers innovative insights and strategies to develop functional starch with glycemic control properties, holding significant scientific and practical value in preventing diseases associated with abnormal glucose metabolism. Full article

Background: Spontaneous orbital cephaloceles are a rare condition. The purpose of this study is to provide a description of a clinical case and to carry out a systematic literature review. Methods: A systematic review of the English literature published on the Pubmed, Scopus, and Web of Science databases was conducted, according to the PRISMA recommendations. Results: A 6-year-old patient was admitted for right otomastoiditis and thrombosis of the sigmoid and transverse sinuses, as well as the proximal portion of the internal jugular vein. Radiological examinations revealed a left orbital mass (22 × 14 mm) compatible with asymptomatic orbital meningocele (MC) herniated from the superior orbital fissure (SOF). The child underwent a right mastoidectomy. After the development of symptoms and signs of intracranial hypertension (ICH), endovascular thrombectomy and transverse sinus stenting were performed, with improvement of the clinical conditions and reduction of the orbital MC. The systematic literature review encompassed 29 publications on 43 patients with spontaneous orbital MC. In the majority of cases, surgery was the preferred treatment. Conclusions: The present case report and systematic review highlight the importance of ICH investigation and a pathophysiological-oriented treatment approach. The experiences described in the literature are limited, making the collection of additional data paramount. Full article

The Upper Permian Longtan Formation in the Laoshan Uplift of the South Yellow Sea Basin hosts thick and distinctive tight sandstones. However, a comprehensive understanding of its pore structure and reservoir classification remains lacking. This study investigates the fully cored well, CSDP-2, utilizing thin section analysis, scanning electron microscopy, energy spectrum analysis, X-ray diffraction, high-pressure mercury intrusion, and nuclear magnetic resonance to characterize its petrophysical properties, pore space, and movable fluid characteristics. Additionally, fractal principles are further employed to examine reservoir heterogeneity and conduct a quantitative assessment, considering the complexity of tight sandstone pore structures. The findings reveal that the sandstones predominantly comprise feldspathic litharenites, with an average porosity of 1.567% and permeability of 0.099 mD, primarily containing intragranular pores. Two distinct sets of pores with significantly different sizes (r < 2 μm; r > 6 μm) were identified, displaying relatively high fractal dimensions and discrete distribution. Movable fluids primarily occupy pores with radii > 0.019 μm, reflecting pronounced overall heterogeneity. The reservoir was classified into three categories utilizing permeability, median radius, and movable fluid saturation as key evaluation parameters, with Class I representing a relatively high-quality reservoir. These findings advance our understanding of the pore development mechanism of tight sandstone reservoirs and provide geological evidence for further hydrocarbon exploration in this study area. Full article

Antibiotics are commonly used to prevent and control aquaculture diseases. However, long-term overuse of antibiotics not only leaves residues but also leads to changes in the nitrogen cycle in water, which threatens the survival of aquaculture organisms. The current results showed that sulfamethoxazole had no significant effect on the nitrogen cycle process in the actual aquaculture concentration. The inhibitory effect of 1.05 mg/L norfloxacin on ammonia-oxidizing bacteria was significantly greater than that on ammonia-oxidizing archaea, and the gene abundance of AOB amoA on the 14th day increased by 2.48 times compared with the 7th day. Under the influence of 3.9 mg/L oxytetracycline, the gene abundance of AOB amoA decreased significantly, while the number of AOA amoA genes increased, suggesting that there may be functional redundancy between AOA and AOB. At the genus level in the norfloxacin group, the relative abundance of Sva0485 increased by 14.0% on the 7th day compared with the control group but decreased 12.77% in the addition group. The relative abundance of Firmicutes, another dominant species in the oxytetracycline group, was 25.9%. This study shows that the addition of antibiotics may have a negative effect on the nitrogen-cycling microorganisms in aquaculture water. Full article

The surface modification of amorphous carbon nanospheres (ACNs) through templates has attracted great attention due to its great success in improving the electrochemical properties of lithium storage materials. Herein, a safe methodology with toluene as a soft template is employed to tailor the nanostructure, resulting in ACNs with tunable surface pores. Extensive characterizations through transmission electron microscopy (TEM), scanning electron microscopy (SEM), Raman spectroscopy, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and nitrogen adsorption/desorption isotherms elucidate the impact of surface pore modifications on the external structure, morphology, and surface area. Electrochemical assessments reveal the enhanced performance of the surface-pore-modified carbon nanospheres, particularly ACNs-100 synthesized with the addition of 100 μL toluene, in terms of the initial discharge capacity, rate performance, and cycling stability. The interesting phenomenon of persistent capacity increase is ascribed to lithium ion movement within the graphite-like interlayer, resulting in ACNs-100 experiencing a capacity upswing from an initial 320 mAh g⁻¹ to a zenith of 655 mAh g⁻¹ over a thousand cycles at a rate of 2 C. The findings in this study highlight the pivotal role of tailored nanostructure engineering in optimizing energy storage materials. Full article

In this study, a material based on polyethylene (PE) and microcrystalline cellulose (MC) was developed as a breathable packaging film. Surface functionalization of MC with 3-aminopropyltriethoxysilane (APTES) has been shown to be an efficient option to tailor their properties and increase opportunities for the application of MC on the reinforcement of polymers such as polyethylene (PE). The functionalization of MC with the mentioned silane derivative was achieved using a green method and later used in the development of composites with PE in three percentages (1, 3, and 5%). All the materials were prepared by melt blending and characterized in terms of structural properties (ATR-FTIR and FTIR in transmittance mode, EDX, and SEM), thermal properties (DSC and TGA), thermomechanical properties (DMA), contact angle measurements and permeability to water vapor. The materials demonstrated the potential to be used as breathable film packaging for fresh products. Full article

This paper investigates the structure and phase composition of Al–TiB₂ metal matrix composites prepared from the Al–Ti–B system powder using self-propagating high-temperature synthesis (SHS) in semi-industrial conditions (the amount of the initial powder mixture was 1000 g). The samples produced in semi-industrial conditions do not differ from the laboratory samples, and consist of the aluminum matrix and TiB₂ ceramic particles. The temperature rise leads to the growth in the average size of TiB₂ particles from 0.4 to 0.6 µm as compared to the laboratory samples. SHS-produced composites are milled to the average particle size of 42.3 µm. The powder particles are fragmented, their structure is inherited from the SHS-produced Al–TiB₂ metal matrix composite. The obtained powder can be used as the main raw material and additive in selective laser sintering, vacuum sintering, and hot pressing products. It is worth noting that these products can find their own application in the automotive industry: brake pads, drums, rail discs, etc. Full article

Incorporating sustainability principles into university and college course offerings is pivotal in molding future leaders and innovators. This study focuses on the Philippines, where higher education institutions (HEIs) increasingly embed sustainability into their academic and operational frameworks. This study aims to quantitatively assess the level of teacher intention to integrate sustainability into curricula in higher education. Utilizing the expanded Theory of Planned Behavior (TPB), it examines the relationships between sustainability knowledge, concern for sustainability, perceived behavioral control, subjective norms, attitude towards sustainability integration, and the intention to integrate sustainability. The methodology involves a cross-sectional study using a web-based survey disseminated through multiple platforms. The sample size was determined through a priori calculation and proportional stratified sampling, with 227 respondents. Utilizing Structural Equation Modeling (SEM) and the Theory of Planned Behavior (TPB), this study uncovers that educators’ attitudes notably shape intentions to integrate sustainability into curricula. While the direct effect of perceived behavioral control is limited, institutional support is deemed to be crucial. Additionally, sustainability concerns strongly influence educators’ intentions, emphasizing the necessity for environmental awareness. These findings inform policymaking and underscore the significance of fostering sustainable practices in higher education through institutional support and awareness initiatives. Finally, this study aims to enhance the effectiveness of sustainability education in the Philippines and contribute to global sustainability efforts. Full article

Background: Cytomegalovirus (CMV) infection represents a major issue worldwide, since it constitutes the most common viral congenital infection, with a prevalence of 0.58% and 1–5% in developed and developing countries, respectively. According to recent studies, prenatal treatment significantly decreases the risk of vertical CMV transmission, and early intervention may even prevent the termination of pregnancy. This study aimed to investigate the level of awareness of CMV among pregnant patients through a semi-systematic review. Methods: We included all of the original articles investigating knowledge and awareness about CMV infection among pregnant women. Our research included the PubMed database. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 statement, the Covidence system automatically guided us to screen the titles and/or abstracts, and then full-texts, followed by data extraction from the eligible studies. Results: We screened 764 studies altogether, with 13 studies included in this analysis. Knowledge about the existence of CMV infection risk varied between the articles, ranging from 11.4% in a study performed in Ireland to 60% reported in a study on the French population. Studies analyzing the impact of educational interventions on patients’ knowledge about preventive measures reported significant improvement compared to their level of awareness before the intervention. Conclusions: Patients’ awareness and knowledge about CMV seemed to be generally low or very low during the last decade before the development of effective secondary prevention methods. Educational interventions seem to be effective, and therefore their wide use could be of potential benefit. In the era of available secondary prevention of vertical transmission, it is crucial to concentrate the efforts of different stakeholders to increase the awareness of cCMV among pregnant women. Full article

Magnetization reduction roasting is an important method for the utilization of oolitic magnetite. In this study, the magnetization reduction behavior and kinetics of oolitic hematite in gas-based roasting were systematically investigated by X-ray photoelectron spectroscopy (XPS). The results revealed that under optimal roasting conditions of 650 °C, a roasting time of 60 min, and a CO concentration of 30%, the magnetization reduction rate of the roasted product reached 44.34%. Furthermore, the weak magnetic separation concentrate presented a TFe of 58.09% and a concentrate iron recovery of 94.3%. The results of the XPS spectrum indicated that the peak area ratio (Fe²⁺/Fe³⁺) gradually increased with an increase in roasting temperature, roasting time, and CO concentration, while over-reduction occurred when the roasting temperature exceeded 750 °C. The investigation of magnetization roasting kinetics for varying particle sizes demonstrated that the magnetization reduction process is controlled by chemical reaction, with a corresponding activation energy range of 42.96 kJ/mol to 63.29 kJ/mol, indicating the particle size has little effect on the magnetization reduction of oolitic hematite. Full article

Chronic myeloid leukemia (CML) is a hematopoietic stem cell disorder characterized by the presence of the Philadelphia chromosome, a product of the reciprocal translocation t(9;22)(q34;q11), in the BCR and ABL genes. These rearrangements in both genes lead to the formation of various fusion mRNA products, with preferential expression of b2a2, b3a2, and other BCR::ABL1 mRNA variants, combined with additional chromosomal abnormalities. Notably, the distribution and frequency of different mRNA variants vary in different populations. However, studies concerning this in Mexico are limited, and the results have been inconclusive. This study therefore aimed to determine the distribution of BCR::ABL1 mRNA variants in different clinical phases of CML and their effect on hematological parameters and patient survival. This study included 33 patients, whose demographic, clinical, and molecular data on BCR::ABL1 mRNA variants and hematological parameters were collected to identify potential associations. A total of 84.8% (n = 28) of patients had BCR::ABL1 translocation and increased platelet and basophil counts. The most frequent mRNA variant was b3a2 (64.3%), followed by b2a2 (28.6%) and e1a2 (3.6%). Concerning the clinical phases of CML, 75.8% (n = 25), 21.2% (n = 7), and 3% (n = 1) of patients were in the chronic, blast, and accelerated phases, respectively. Moreover, the b3a2 mRNA variant was more commonly identified in patients in the chronic phase. No correlation was observed between mRNA variant expression and patient survival. However, b2a2 was indicative of patients with longer survival as well as those treated with imatinib or nilotinib. Additionally, platelet count could be a marker of BCR::ABL1 translocation. Full article

The realization of a BRST cohomology of the 4D topological gauge-affine gravity is established in terms of a superconnection formalism. The identification of fields in the quantized theory occurs directly as is usual in terms of superconnection and its supercurvature components with the double covering of the general affine group $\overline{GA}(4,\mathbb{R})$. Then, by means of an appropriate decomposition of the metalinear double-covering group $\overline{SL}(5,\mathbb{R})$ with respect to the general linear double-covering group $\overline{GL}(4,\mathbb{R})$, one can easily obtain the enlargements of the fields while remaining consistent with the BRST algebra. This leads to the descent equations, allowing us to build the observables of the theory by means of the BRST algebra constructed using a $\overline{sa}(5,\mathbb{R})$ algebra-valued superconnection. In particular, we discuss the construction of topological invariants with torsion. Full article

Given the ever-changing world of technological advances, and due to the fact that business entities strive for efficiency and cost reduction, open innovation (OI) has become the focus of academic and scholarly discussions. Furthermore, to increase their competitiveness, small and medium enterprises (SMEs) have started implementing OI practices. This study aims to investigate the impact of SMEs’ internal organizational practices on OI and the impact of the latter on SMEs’ business performance. This quantitative study, which was based on gathering insights from SMEs, sought to answer two research questions related to the effects of organizational practices on the adoption and management of OI processes in SMEs and the role of OI in accelerating the business performance of SMEs. The findings revealed that not all SMEs’ internal organizational practices have a positive impact on both OI and SMEs’ business performance. This study is among the earliest studies in the UAE and GCC region to explore the impact of specific internal organizational practices on SME OI adoption and its business performance. The present study contributes theoretically and practically to OI literature and assists SME managers in evaluating their internal organizational practices’ suitability for OI adoption. Full article

Background: The periodization of physical exercise to optimize objectives is common in competitive sports. However, physical exercise programs for older adults only sometimes present periodization in their programming. Therefore, this article aims to research the results of applying the sports periodized method to older adults. Methods: A total of 137 participants over 60 years old performed a physical exercise program; 71 participated in a multi-component non-periodized program as the Control Group (CG), and 66 participated in a program periodized in blocks as the Experimental Group (EG). The block periodization program was oriented to the development of strength and was carried out in 86 sessions thrice weekly for eight months. Anthropometric assessments were made using weight, height, Body Mass Index, and electrical bioimpedance; and functional evaluations were made through standardized tests: Short Performance Physical Battery (SPPB), Timed Up & Go (TUG), handgrip, and a two-minute stair test. Results: After the intervention, the EG significantly improved TUG, weight, and BMI. On the other hand, the CG showed significant improvements in fat weight, BMI, and the 2 min stair test. The SPPB did not show changes after the intervention. Conclusion: The periodization of physical exercise for older adults does not significantly impact functional capacity in this population group. Full article

This paper reviews the dynamics of a single isotropic and homogeneous scalar field $\phi \left(t\right)$ in the context of cosmological models. A non-standard approach to the solution of the Einstein–Klein–Gordon equations is described which uses the scalar field as the evolution parameter for cosmic dynamics. General conclusions about the qualitative behaviour of the solutions can be drawn, and examples of how to obtain explicit solutions for some cosmological models of interest are given. For arbitrary potentials, analytical results can be obtained from the slow-roll approximation by using a series expansion for the Hubble parameter $H\left[\phi \right]$, from which a quantitative estimate for the number of e-folds of expansion is obtained. This approach is illustrated with the examples of quadratic potentials and hilltop models, with special consideration of Higgs-type potentials. The GUT-scale is shown to come out of such a model quite naturally. Finally, it is discussed how to find scalar potentials giving rise to a predetermined scalar-field behaviour and the associated evolution of the scale factor. Full article

In many (remote) rural areas of Europe and the world, rural communities are facing various challenges. One response is residents leaving their communities. However, there are also many empirical examples of residents staying, launching project initiatives, developing new solutions and experimenting with new practices. This is what we call social innovation. What experiences do actors have in these processes? Can we speak of empowerment? To what extent can such initiatives have an impact on community development? In this article, we explore these questions, for which there is little related empirical research. By applying a multi-sited individualising comparison to case studies in three European countries (Germany, Ireland and Portugal), we obtain empirical evidence of the following dimensions of empowerment that Avelino et al. outline conceptually: the achievement of autonomy, competence and relatedness and also impact, meaning and resilience. Often, however, it is not the individual actors for whom such effects can be reported. Rather, the social initiative as such or the local administration has acquired new skills and autonomy. Regarding community development, ‘pathways to impact’, such as infrastructure improvements and/or the creation of new employment opportunities and/or the influx of new residents, could be identified. However, this development often depended on both opportunity and the cooperation and goodwill of many stakeholders. Full article

Medical education acknowledges our need to teach our physicians about “social determinants of health” and “health care disparities”. However, educators often lack actionable training to address this need. We describe a faculty development activity, a health disparities journal club, using the jigsaw strategy with the intent of increasing awareness, encouraging self-directed learning, and inspiring future teaching of the subject to health professional learners. We completed six workshops at six individual hospitals, with 95 total attendees in medicine and numerous other health professions. Our evaluation asked trainees to: report the number of journal articles about health disparities they had read, excluding the assigned journal club articles, in the past 12 months, and to predict future plans for reading about health disparities. In total, 28.9% responded they had “never read” a prior article on health or healthcare disparities, while 54.2% responded “1–5 articles”. Many (60%) reported they would continue to investigate this topic. Our experience has demonstrated the utility and positive impact of a “flipped classroom” jigsaw method, showing it can be used successfully in Inter-Professional (IPE) Faculty Development to increase active exposure and discussion of the content. Additionally, this method promotes individual reflection and enhances continued collective engagement. Full article

This article attempts to answer the following question: why did the author of the apocryphon called 1 Apocryphal Apocalypse of John choose to efface himself and adopt John as his pseudonym? Why not Peter or Paul? This paper argues that the author of 1 Apocryphal Apocalypse of John intended to harness the audience attached to John, the seer of Revelation, by taking his name as a pseudonym. This paper sustains this claim by demonstrating that, in antiquity, each author had a specific pool of readers, often made out of friends and accolades of the author. Thus, authors’ names evoke an audience attached to them. When an author takes another person’s name to write under, he does so out of necessity, because he does not have an audience. But, when he takes another’s person name, he does so hoping to trick the audience of the impersonated into reading him. Based on this insight, this article concludes that the author of 1 Apocr. Apoc. John wanted the readers of canonical Revelation to engage with his work and that he achieved his purpose as evinced by the fact that the titles of both works share an uncanny resemblance, ranging from identical titles to similar wording. Since titles in antiquity were given to the works by their readers, the most logical explanation for canonical Revelation and 1 Apocr. Apoc. John having the same titles is that they both shared the same readers. Finally, this article argues that, in line with recent research on the use of pseudepigraphy in Jewish, Christian, and Roman contexts, the author of 1 Apocr. Apoc. John wanted to be read by CR’s readers because he wanted to expand, criticize, rework, and update CR’s eschatological discourse, exemplified by a close reading of how 1 Apocr. Apoc. John criticized, reworked, and updated CR’s presentation of the resurrection to bring it in harmony with late Christian reflection on the subject. Full article

Integrin α₄β₇+ T cells perpetuate tissue injury in chronic inflammatory diseases, yet their role in hepatic fibrosis progression remains poorly understood. Here, we report increased accumulation of α₄β₇+ T cells in the liver of people with cirrhosis relative to disease controls. Similarly, hepatic fibrosis in the established mouse model of CCl₄-induced liver fibrosis was associated with enrichment of intrahepatic α₄β₇+ CD4 and CD8 T cells. Monoclonal antibody (mAb)-mediated blockade of α₄β₇ or its ligand mucosal addressin cell adhesion molecule (MAdCAM)-1 attenuated hepatic inflammation and prevented fibrosis progression in CCl₄-treated mice. Improvement in liver fibrosis was associated with a significant decrease in the infiltration of α₄β₇+ CD4 and CD8 T cells, suggesting that α₄β₇/MAdCAM-1 axis regulates both CD4 and CD8 T cell recruitment to the fibrotic liver, and α₄β₇+ T cells promote hepatic fibrosis progression. Analysis of hepatic α₄β₇+ and α₄β₇- CD4 T cells revealed that α₄β₇+ CD4 T cells were enriched for markers of activation and proliferation, demonstrating an effector phenotype. The findings suggest that α₄β₇+ T cells play a critical role in promoting hepatic fibrosis progression, and mAb-mediated blockade of α₄β₇ or MAdCAM-1 represents a promising therapeutic strategy for slowing hepatic fibrosis progression in chronic liver diseases. Full article

Pancreatic cancer is one of the most aggressive, heterogeneous, and fatal types of human cancer; therefore, more effective therapeutic drugs are urgently needed. Human epidermal growth factor receptor 2 (HER2) overexpression and amplification have been identified as a cornerstone in this pathology. The aim of this review is to identify HER2 membrane overexpression in relation to pancreatic cancer pathways that can be used in order to develop a targeted therapy. After searching the keywords, 174 articles were found during a time span of 10 years, between 2013 and 2023, but only twelve scientific papers were qualified for this investigation. The new era of biomolecular research found a significant relationship between HER2 overexpression and pancreatic cancer cells in 25–30% of cases. The variables are dependent on tumor-derived cells, with differences in receptor overexpression between PDAC (pancreatic ductal adenocarcinoma), BTC (biliary tract cancer), ampullary carcinoma, and PNETs (pancreatic neuroendocrine tumors). HER2 overexpression is frequently encountered in human pancreatic carcinoma cell lines, and the ERBB family is one of the targets in the near future of therapy, with good results in phase I, II, and III studies evaluating downregulation and tumor downstaging, respectively. Full article