Silicon steel (electrical steel) has been used in electric motors that are important components in sustainable new energy Electrical Vehicles (EVs). The Ruhrstahl–Heraeus process is commonly used in the refining process of silicon steel. The refining effect inside the RH degasser is closely related to the flow and mixing of molten steel. In this study, a 260 t RH was used as the prototype, and the transport process of the passive scalar tracer (virtual tracer) and salt tracer (considering density effect) was studied using numerical simulation and water model research methods. The results indicate that the tracer transports from the up snorkel of the down snorkel to the bottom of the ladle, and then upwards from the bottom of the ladle to the top of the ladle. Density and gravity, respectively, play a promoting and hindering role in these two stages. In different areas of the ladle, density and gravity play a different degree of promotion and obstruction. Moreover, in different regions of the ladle, the different circulation strength leads to the different promotion degrees and obstruction degrees of the density. This results in the difference between the concentration growth rate of the salt tracer and the passive scalar in different regions of the ladle top. From the perspective of mixing time, density and gravity have no effect on the mixing time at the bottom of the ladle, and the difference between the passive scalar and NaCl solution tracer is within the range of 1–5%. For a larger dosage of tracer case, the difference range is reduced. However, at the top of the ladle, the average mixing time for the NaCl solution case is significantly longer than that of the passive scalar case, within the range of 3–14.7%. For a larger dosage of tracer case, the difference range is increased to 17.4–41.1%. It indicates that density and gravity delay the mixing of substances at the top area of the ladle, and this should be paid more attention when adding denser alloys in RH degasser. Full article

Humulus lupulus (hop) is a necessary material in beer brewing because its female inflorescences (called hop cones) give a floral aroma, bitterness and foam stability to beer. Various aspects of growth conditions in the cultivation area, especially temperature, strongly affect the yield and quality of hop cones. Recent estimates suggest that climate change accompanied by global warming is negatively impacting hop production, with high temperatures reducing the expression of genes that regulate beneficial secondary metabolites in hops. This underscores the need for techniques to enhance hop tolerance to high temperatures. This study explores the potential of N-acectylglutamic acid (NAG), a non-proteinogenic amino acid, to confer hops with tolerance against oxidative and heat stress by suppressing ROS accumulation. Exogenous NAG treatment activated the expression of HlZAT10/12 and HlHSFA2, which are putative homologues considered master regulators in response to oxidative and heat stress in Arabidopsis thaliana (Arabidopsis). Additionally, histone acetylation, a histone modification associated with transcriptional activation, was increased at these stress-responsive genes in the NAG-treated hops. These findings reveal NAG as a potential chemical compound to mitigate hop production reduction caused by high temperatures and suggest the conservation of epigenetic modification-mediated regulation of gene expression in response to environmental stresses in hops. Full article

Alport Syndrome (AS) is the most common genetic glomerular disease, and it is caused by COL4A3, COL4A4, and COL4A5 pathogenic variants. The classic phenotypic spectrum associated with AS ranges from isolated hematuria to chronic kidney disease (CKD) with extrarenal abnormalities. Atypical presentation of the disorder is possible, and it can mislead the diagnosis. Polycystic kidney disease (PKD), which is most frequently associated with Autosomal Dominant PKD (ADPKD) due to PKD1 and PKD2 heterozygous variants, is emerging as a possible clinical manifestation in COL4A3-A5 patients. We describe a COL4A5 novel familial frameshift variant (NM_000495.5: c.1095dup p.(Leu366ValfsTer45)), which was associated with AS and PKD in the hemizygous proband, as well as with PKD, IgA glomerulonephritis and focal segmental glomerulosclerosis (FSGS) in the heterozygous mother. Establishing the diagnosis of AS can sometimes be difficult, especially in the context of misleading family history and atypical phenotypic features. This case study supports the emerging genotypic and phenotypic heterogeneity in COL4A3-A5-associated disorders, as well as the recently described association between PKD and collagen type IV (Col4) defects. We highlight the importance of the accurate phenotyping of all family members and the relevance of next-generation sequencing in the differential diagnosis of hereditary kidney disease. Full article

With new artificial intelligence (AI) technologies and application scenarios constantly emerging, AI technology has become widely used in astronomy and has promoted notable progress in related fields. A large number of papers have reviewed the application of AI technology in astronomy. However, relevant articles seldom mention telescope intelligence separately, and it is difficult to understand the current development status of and research hotspots in telescope intelligence from these papers. This paper combines the development history of AI technology and difficulties with critical telescope technologies, comprehensively introduces the development of and research hotspots in telescope intelligence, conducts a statistical analysis of various research directions in telescope intelligence, and defines the merits of these research directions. A variety of research directions are evaluated, and research trends in each type of telescope intelligence are indicated. Finally, according to the advantages of AI technology and trends in telescope development, potential future research hotspots in the field of telescope intelligence are given. Full article

Recent techniques for forming thermoplastics, such as welding, automated fibre placement or additive manufacturing, generate successive rapid heating and cooling cycles that cause the partial melting of crystals during the process. The melting of an interface is essential to guarantee a good molecular diffusion across the welded parts. Nevertheless, no model can correctly predict the melting kinetics and consequently the evolution of the crystalline degree during the layers’ deposition process. The purpose of this paper was to define the melting kinetics depending on the crystallization conditions for polyetheretherketone (PEEK). Firstly, a non-isothermal crystallization model was proposed over a wide range of cooling rates from 0.1 K.s⁻¹ to 150 K.s⁻¹. Experimental results have highlighted a dual-mode behaviour of melting and demonstrated the dependence of melting temperatures on crystallization conditions. Based on these observations, a model was developed to predict the melting behaviour after non-isothermal crystallization. The melting model revealed that after high cooling rates, primary and secondary crystals melt separately at low temperatures, while after slow cooling rates, both structures melt simultaneously at higher temperatures. Finally, the melting model was applied to the FFF thermal cycle to illustrate the influence of process parameters on the melting kinetics during deposition. Full article

Neighborhood social vulnerability is a dimension of vulnerability that influences society’s response to external factors, encompassing various social factors tied to socioeconomic and demographic attributes at the neighborhood level. While previous studies have explored the associations between vulnerable neighborhoods and stressors like environmental hazards, understanding of their impact on residents’ social capital remains limited. Moreover, the role of built environments in mitigating these effects is uncertain. This study investigates the impact of neighborhood social vulnerability, alongside streetscape features, on individual social capital in Seoul, South Korea. Using a stratified random sampling method, we surveyed 1000 Seoul residents, assessing their social capital and demographics. In particular, six questionnaires based on a four-point Likert scale were used to measure the individual level of social capital: two questions for social networks, three questions for social participation, and one question for sense of community. Additionally, we employed a deep learning-based model to analyze Google Street View images for detailed streetscape features. Our analysis, utilizing multiple and ordinal logistic regression models, reveals that walkable environments and neighborhood prosperity, indicated by factors like income, education, and street greenery, are linked to higher social capital. Moreover, less urbanized areas with lower land prices and greater openness to the sky also show positive associations. These findings underscore the potential of improving streetscape features to mitigate the negative impacts of neighborhood vulnerability, particularly in neighborhoods where low-income and less-educated residents are concentrated, offering insights for urban planners and community leaders. Full article

Pediatric basilar skull fractures (BSFs) are a rare type of traumatic head injury that can cause debilitating complications without prompt treatment. Here, we sought to review the literature and characterize the clinical features, management, and outcomes of pediatric BSFs. We identified 21 relevant studies, excluding reviews, meta-analyses, and non-English articles. The incidence of pediatric BSFs ranged from 0.0001% to 7.3%, with falls from multi-level heights and traffic accidents being the primary causes (9/21). The median presentation age ranged from 3.2 to 12.8 years, and the mean age of patients across all studies was 8.68 years. Up to 55% of pediatric BSFs presented with intracranial hematoma/hemorrhage, along with pneumocephalus and edema. Cranial nerve palsies were a common complication (9/21), with the facial nerve injured most frequently (7/21). While delayed cranial nerve palsy was reported in a few studies (4/21), most resolved within three months post-admission. Other complications included CSF leaks (10/21) and meningitis (4/21). Management included IV fluids, antiemetics, and surgery (8/21) to treat the fracture directly, address a CSF leak, or achieve cranial nerve compression. Despite their rarity, pediatric skull base fractures are associated with clinical complications, including CSF leaks and cranial nerve palsies. Given that some of these complications may be delayed, patient education is critical. Full article

In the current work, the synergy between natural compounds and conventional chemotherapeutic drugs is comprehensively reviewed in light of current preclinical research findings. The prognosis for lung cancer patients is poor, with a 5-year survival rate of 18.1%. The use of natural compounds in combination with conventional chemotherapeutic drugs has gained significant attention as a potential novel approach in the treatment of lung cancer. The present work highlights the importance of finding more effective therapies to increase survival rates. Chemotherapy is a primary treatment option for lung cancer but it has limitations such as reduced effectiveness because cancer cells become resistant. Natural compounds isolated from medicinal plants have shown promising anticancer or chemopreventive properties and their synergistic effect has been observed when combined with conventional therapies. The combined use of an anti-cancer drug and a natural compound exhibits synergistic effects, enhancing overall therapeutic actions against cancer cells. In conclusion, this work provides an overview of the latest preclinical research on medicinal plants and plant-derived compounds as alternative or complementary treatment options for lung cancer chemotherapy and discusses the potential of natural compounds in treating lung cancer with minimal side effects. Full article

Psychedelic therapy is increasingly acknowledged as a transformative approach to mental health care, much like how Virtual Reality (VR) technology has emerged as a potent tool in the realm of mental health. Hence, there is potential for integrating the benefits derived from both. This review aims to assess the current state of the art concerning the utilization of VR and psychedelic simulations for treating psychological disorders. The findings clarify the potential of an emerging treatment: the simulation of psychedelic states through Virtual Reality. This treatment has been shown to improve cognitive flexibility and executive functions and, as a result, could be used to prevent conditions such as mild cognitive impairment and dementia. Furthermore, this treatment facilitates the activation of other constructs in the subject, such as creativity, joy, pleasure, and relaxation, which can act as mediators in the treatment of various psychopathological disorders. This review attempts to broaden knowledge regarding the simulation of psychedelic states through Virtual Reality, exposing the results in a clinical setting and highlighting the need for further studies. Full article

Stressors are directly related to major events throughout the beef cattle production cycle. Understanding the impact stressors have on productive outcomes is critical for the efficient implementation of management strategies. Such stressors include environmental extremes, nutritional deprivation, and common management procedures. Environmental extremes such as thermal stress can disturb gestating cows’ normal physiological responses, hindering reproductive efficiency. Thermal stress during the breeding season can affect embryo development causing a decrease in conception rates, although adjusting the scheduling of breeding activities can minimize losses. Additionally, suboptimal nutrition may negatively impact reproductive performance if management strategies including modifying seasonal grazing practices are not implemented. As gestation progresses, nutrient requirements increase; thus, without appropriate dietary management, poor calf performance, the loss of the body condition score, and reduced reproductive performance may result. While weaning is a common management procedure, this event is another major stress within the production system. Applying efficient strategies such as creep feeding or two-step weaning to mitigate weaning stress can maximize production efficiency. This review will explore in-depth the stressors associated with production events in the beef cattle industry and give insight into researched management strategies targeting these stressors that will improve the sustainability of the production system. Full article

Background: Previous studies demonstrate an association between metabolic factors and Helicobacter pylori-related gastric cancer. However, the association of gastric atrophy or intestinal metaplasia (IM) with these factors remains unknown. Methods: Data on 1603 Helicobacter pylori-positive patients who underwent esophagogastroduodenoscopy between 2001 and 2021 were evaluated. The outcome measures were endoscopic atrophy, IM grade, and the incidence of endoscopically diagnosed and pathologically confirmed gastric neoplasms. Clinical factors associated with these findings were also determined. Results: Advanced age; successful Helicobacter pylori eradication; and comorbidities including diabetes mellitus (DM), hypertension, dyslipidemia, and fib4 index were significantly associated with endoscopic gastric atrophy grade. Male sex; advanced age; and comorbidities including DM, hypertension, dyslipidemia, hyperuricemia, fatty liver, aortic calcification, and fib4 index were also significantly associated with endoscopic IM grade, whereas advanced age, successful Helicobacter pylori eradication, DM, fatty liver, and fib4 index were significantly associated with the incidence of gastric neoplasms. Conclusion: Several metabolic disorders, including DM, hypertension, dyslipidemia, hyperuricemia, and fatty liver disease, are risk factors for advanced-grade gastric atrophy, intestinal metaplasia, and gastric neoplasms. Risk stratification according to these factors, particularly those with metabolic disorders, would affect EGD surveillance for Helicobacter pylori-positive patients. Full article

While the importance of conversion surgery has increased with the development of systemic chemotherapy for gastric cancer (GC), reports of conversion surgery for patients with GC with distant metastasis and tumor thrombus are extremely scarce, and a definitive surgical strategy has yet to be established. Herein, we report a 67-year-old man with left abdominal pain referred to our hospital following a diagnosis of unresectable GC. Esophagogastroduodenoscopy and contrast-enhanced abdominal computed tomography (CT) revealed advanced GC with splenic metastasis. A splenic vein tumor thrombus (SVTT) and a continuous thrombus to the main trunk of the portal vein were detected. The patient was treated with anticoagulation therapy and systemic chemotherapy comprising S-1 and oxaliplatin. One year following chemotherapy initiation, a CT scan revealed progressive disease (PD); therefore, the chemotherapy regimen was switched to ramucirumab with paclitaxel. After 10 courses of chemotherapy resulting in primary tumor and SVTT shrinkage, the patient underwent laparoscopic total gastrectomy (LTG) and distal pancreaticosplenectomy (DPS). He was discharged without complications and remained alive 6 months postoperatively without recurrence. In summary, the wait-and-see approach was effective in a patient with GC with splenic metastasis and SVTT, ultimately leading to an R0 resection performed via LTG and DPS. Full article

The aim of this study was to evaluate outcomes of transarterial radioembolization (TARE) for hepatocellular carcinoma (HCC) in patients previously treated with transarterial embolization (TAE). In this retrospective study, all HCC patients who received TARE from 1/2012 to 12/2022 for treatment of residual or recurrent disease after TAE were identified. Overall survival (OS) was estimated using the Kaplan–Meier method. Univariate Cox regression was performed to determine significant predictors of OS after TARE. Twenty-one patients (median age 73.4 years, 18 male, 3 female) were included. Median dose to the perfused liver volume was 121 Gy (112–444, range), and 18/21 (85.7%) patients received 112–140 Gy. Median OS from time of HCC diagnosis was 32.9 months (19.4–61.4, 95% CI). Median OS after first TAE was 29.3 months (15.3–58.9, 95% CI). Median OS after first TARE was 10.6 months (6.8–27.0, 95% CI). ECOG performance status of 0 (p = 0.038), index tumor diameter < 4 cm (p = 0.022), and hepatic tumor burden < 25% (p = 0.018) were significant predictors of longer OS after TARE. TARE may provide a survival benefit for appropriately selected patients with HCC who have been previously treated with TAE. Full article

This paper recasts four geodetic curves—the great ellipse, the normal section, the loxodrome, and the curve of alignment—into a parametric form of vector-algebra formula. These formulas allow these curves to be drawn using simple, efficient, and robust algorithms. The curve of alignment, which seems to be quite obscure, ought not to be. Like the great ellipse and the loxodrome, and unlike the normal section, the curve of alignment from point A to point B (both on the same ellipsoid) is the same as the curve of alignment from point B to point A. The algorithm used to draw the curve of alignment is much simpler than any of the others and its shape is quite similar to that of the geodesic, which suggests it would be a practical surrogate when drawing these curves. Full article

Strategic communication can motivate target audiences to take conservation action. Yet, whether audiences are motivated by more information or more influential visuals is unclear. Using online surveys, we compared different visual communication strategies using text, graphics, and photographs for encouraging parrotfish-friendly conservation behaviors to see which one yields greater emotion, interest, and intended action. Experiment 1 explored whether a scientific-oriented poster would be more or less effective in promoting conservation behaviors than a graphical poster using social marketing techniques. Experiment 2 contrasted the two posters with a photograph and graphic icons without text against a blank control. Results revealed how engaging visuals can inspire reactions and behavioral intentions. The posters both elicited positive reactions, but with less text and content to process, the social marketing poster more efficiently inspired the desired reactions. This work highlights that conservation communications can strategically use psychology and graphics to efficiently inspire desired actions. Full article

We have kinetically estimated the enzymatic redox reaction at the horseradish peroxidase (HRP)-modified electrode combined with ionic liquids by adding N-(2-methoxythethyl)-N-methylpyrrolidinium bis(trifluoromethane sulfonyl)imide (MEMPTFSI) to HRP/carbon paste (CP)/Ketjenblack EC600JC (EC). The fluctuation of the steady-state reduction current of HRP at the HRP/CP-modified electrode progressively increased as the applied potential was lowered. The enzymatic redox reaction with hydrogen peroxide as a substrate at the HRP/CP/EC/MEMPTFSI-modified electrode and the HRP/CP-modified electrode could be correlated by the Michaelis–Menten equation. The Michaelis constant of the enzymatic redox reaction at the HRP/CP/EC/MEMPTFSI-modified electrode was the same as that at the HRP/CP-modified electrode. On the other hand, the turnover number of the enzymatic redox reaction at the HRP/CP/EC/MEMPTFSI-modified electrode was six times larger than that at the HRP/CP-modified electrode. Consequently, the specificity constant of the enzymatic redox reaction at the HRP/CP/EC/MEMPTFSI-modified electrode was much higher than that at the HRP/CP-modified electrode. Full article

Refugee and migration crises has been an integral part of the continuous and successive crises that the world has been experiencing. Media has played a crucial role in shaping public opinion over migration and asylum-seeking. Within this context, this paper aims to discuss Greek media coverage of the migrant shipwreck off the Greek coast of Pylos, in June 2023, in which more than 600 people mostly from Syria, Egypt, and Pakistan are thought to have drowned. Based on data from a quantitative content analysis and a sample of news stories stemming from the online version of five Greek news media outlets, representing diverse political spaces, a broader set of criteria for content analysis, including the absence of refugee and migrant voice in media content, dehumanization, absence of solutions and context, among many others, was used in order to explore how the Greek media framed what has been labeled as one of the deadliest migrant shipwrecks in the Mediterranean. Results revealed (i) frames of dehumanization, (ii) insufficient reporting of injustice and discrimination stemming from (state) structures and practices, and an (iii) overemphasis on migrant smuggling. Full article

This article proposes a particular strategy to proceed with a progressive electrification of public transport systems in cities. Starting from a bus operation model, the possible electrification of two routes is analyzed, one urban and another extra-urban in the city of Pisa. An estimate is made of the energy uses associated with certain operating modes. The maximum level of consumption is estimated at approximately 280 kWh per day per bus for the urban route and excluding some special days, less than 215 kWh per day for the extra-urban route, for which a hybrid bus is proposed. Starting from an estimate of the daily consumption for the management of the two routes, the sizing of a photovoltaic (PV) plant distributed on some modular shelters which serves to power the same routes, is carried out. The resulting system has a power of the order of 190–200 kW. The modular solution is also outlined, and an installation is proposed. The analyzed case lends itself to being easily replicated. Full article

Introduction: Currently, there is limited evidence for the relationship of Exosome-based Prostate Intelliscore (EPI) and multiparametric magnetic resonance imaging (mpMRI) in stratifying risk for clinically significant prostate cancer. Using a retrospective cohort study design, we sought to characterize the relationship between these two noninvasive metrics and prostate biopsy outcome. Methods: Data were collected via electronic medical record for all patients who underwent EPI testing from 1 January 2019 to 3 February 2022 and had available medical records at a single mid-western university medical center. Positive test result was defined as >15.6 for EPI, ≥3 PI-RADS score and ≥3 + 4 Gleason Score for biopsy findings. Utility of EPI, mpMRI and combined use was characterized through calculation of sensitivity, specificity, positive predictive value, negative predictive value, and ROC analysis. Results: A total of 226 patients were identified as receiving EPI testing for risk stratification of clinically significant prostate cancer. Sensitivity for EPI was 91%, mpMRI was 90%, and the highest was combined use at 96%. With ROC analysis, AUC for EPI alone was 0.57 (95% CI, 0.47–0.67) and 0.78 (95% CI, 0.70–0.87) for mpMRI alone. With prior positive EPI result, AUC for combined use with mpMRI was 0.80 (95% CI, 0.71–0.89). Further subgroup analysis resulted in increased AUC values of EPI 0.67 (95% CI, 0.48–0.87), mpMRI 0.90 (95% CI, 0.76–1.0), and combined 0.90 (95% CI, 0.75–1.0) in the African American population. Discussion: We observed that the combined use of EPI and mpMRI led to an avoided biopsy in 43% of patients. Using both parameters increased the overall sensitivity and diagnostic accuracy in detecting clinically significant prostate cancer. The best test performance was observed in the African American cohort. Identifying optimal noninvasive tools to assess risk for prostate cancer is crucial to providing accurate and cost-effective care. Future study should utilize a prospective study design to further support the combined use of these metrics. Full article

Among the methods of 3D reconstruction, the automatic generation of 3D models from building documentation is one of the most accessible and inexpensive. For 30 years, researchers have proposed multiple methods to automatically generate 3D models from 2D drawings. This study compiles this research and discusses the different methods used to generate 3D models from 2D drawings. It offers a critical review of these methods, focusing on the coverage and completeness of the reconstruction process. This review allows us to identify the research gaps in the literature, and opportunities for improvement are identified for future research. Full article

Background and Objectives: Bone age determination is a valuable method for forensic and disaster identifications of unknown human remains, as well as for medical and surgical procedural purposes. This retrospective research study aimed to determine the age based on epiphyseal fusion stages and investigate differences related to gender. Materials and Methods: X-rays of the knee were collected from medical imaging centers in hospitals in the south of Jordan and examined by two observers who determined the bone epiphyseal phase of closure for the femur, tibia, and fibula bone ends close to the knee based on a three-stage classification. Results: The main results revealed that females showed earlier epiphyseal union (Stage II) at the lower end of the femur and the upper ends of the tibia and fibula compared to males. In males, the start of complete union (Stage III) at knee bones was seen at the age of 17–18 years, while in females, it was seen at the age of 16–17 years. Additionally, knee bones showed complete union in 100% of males and females in the age groups 21–22 years and 20–21 years, respectively. Although females showed an earlier start and end of epiphyseal complete union than males, analysis of collected data showed no significant age differences between males and females at the three stages of epiphyseal union of the knee bones. Conclusions: Findings of the radiographic analysis of bone epiphyseal fusion at the knee joint are a helpful method for chronological age determination. This study supports the gender and ethnicity variation among different geographical locations. Studies with a high sample number would be needed to validate our findings. Full article

Background and Objectives: Primary malignant bone tumors are rare lesions, and their complex treatment can lead to functional impairment. It is important to have a postoperative assessment tool for patients’ functional outcomes to be evaluated and to consequently adapt future treatments in the pursuit of a continuous improvement of their quality of life. The Musculoskeletal Tumor Society Score (MSTS) is a validated specific system score that is used frequently in the follow-up of these patients. We found no information about a valid translated Romanian version of this score neither for the upper limb nor for the lower limb. We proposed in this study to translate the original version of the MSTS Score into Romanian and to perform validation analysis of the Romanian-language MSTS Score. Materials and Methods: We selected 48 patients who underwent limb-salvage surgery after resection of bone sarcomas. Patients were interrogated twice according to the translated Romanian version of the MSTS Score during their follow-up. The translation was performed according to the recommended guidelines. A total number of 96 questionnaires were valid for statistical analysis. Results: Internal consistency and reliability were good for both sets of questionnaires’ analytic measurements, with Cronbach’s alpha values of 0.848 (test) and 0.802 (retest). The test-retest evaluation proved to be statistically strong for reproducibility and validity with Spearman’s rho = 0.9 (p < 0.01, 95% CI). Conclusions: This study permitted the translation of this score and the validation of psychometric data. Our results showed that the Romanian version of the MSTS is a reliable means of assessment of the functional outcome of patients who received limb-salvage surgery for the upper and lower extremities. Full article