The rise in cannabis use prompts significant concerns regarding pharmacy students’ abilities to counsel patients over cannabis use disorder. This study aims to understand pharmacy students’ preparedness to counsel patients with cannabis use disorder (CUD) and evaluate the relationship between knowledge, attitudes towards medical cannabis (MC) and recreational cannabis (RC), and behavior intention (BI) to counsel over CUD. A cross-sectional survey was administered to pharmacy students. Descriptive analyses of sample characteristics were assessed with the t-test and one-way ANOVA test. Pearson correlation and linear regression were conducted, measuring the strength and direction of relationships. The average scores for knowledge, attitudes towards MC use and RC, and behavioral intention were 81% (SD 16%), 4.13 (SD 0.75), 3.28 (0.80), and 2.74 (1.00). Significant correlations were observed between knowledge–attitudes toward MC, knowledge–attitudes towards RC, and attitudes towards RC–behavioral intentions. Linear regression indicated attitudes towards MC use and RC, academic year, awareness of MC use legality, obtained knowledge, and past patient interaction were significantly associated with behavioral intention on confidence in counseling over CUD. There is a gap in students’ behavioral intention to counsel. These findings emphasize the importance of ample preparation that enables student pharmacists to address patient needs related to cannabis use confidently. Full article

This paper is focused on the design and development of the Porcospino Flex, a single-track robot inspired by nature and featuring a meta-material structure. In the earlier version of the Porcospino, the main body was composed of a chain of vertebrae and two end sections linked by flexible joints, but the excessive use of materials in 3D printing and the resulting weight of the robot posed challenges, ultimately leading to a decrease in its overall efficiency and performance. The Porcospino Flex is manufactured through the fused deposition modeling process using acrylonitrile butadiene styrene and thermoplastic polyurethane, featuring a singular meta-material structure vertebral column. The adoption of a lattice structure in the main body of the Porcospino Flex leads to a substantial increase in performance, reducing its weight from 4200 g to 3600 g. Furthermore, the decrease in weight leads to a reduction in material usage and waste, making a substantial contribution to the sustainability of the robot. The discussion focuses on the testing results of the Porcospino Flex prototype, highlighting the enhancements observed compared to its prior version. Full article

Concerns surrounding breast cancer have been increasing, as it leads to the current global cancer incidence and causes a high mortality rate in women. This study investigated the physiological effects of common dietary polyphenols that might prevent breast cancer progression. Quercetin, kaempferol, and rosmarinic acid were selected to explore their potential bioactivities. Each polyphenol was formulated into a microemulsion to improve its bioactivity and bioavailability. In vitro antioxidant and cytotoxicity activities of the selected polyphenols and their microemulsion forms were further investigated. The optimized microemulsion carrier with 1% oleic acid, 3% ethanol, 10% polysorbate 20, and 86% ultrapure water achieved more than 90% polyphenol encapsulation efficiency. The microemulsion was stable for more than 30 days when encapsulating polyphenol in the fluctuating temperature treatment. In vitro studies suggested that rosmarinic acid-loaded microemulsion had the best antioxidant activity compared with other polyphenol-loaded microemulsions (PL-MEs). Blank microemulsion and all PL-MEs significantly inhibited the proliferation of both hormone-dependent (T47D) and hormone-independent (MDA-MB-231) breast cancer cells. More studies are warranted to confirm the contribution of the microemulsion carrier components to the polyphenols’ improved antioxidant activity and high toxicity of PL-MEs on breast cancer cells. Full article

Thermo-vortices (bright spots, blobs, swirls) in cosmic fluids (planetary atmospheres, or even black hole accretion disks) are sometimes observed as clustered into quasi-symmetrical quasi-stationary groups but conceptualized in models as autonomous items. We demonstrate—using the (analytical) Sharp Boundaries Evolution Method and a generic model of a thermo-vorticial field in a rotating “thin” fluid layer in a spacetime that may be curved or flat—that these thermo-vortices may be not independent but represent interlinked parts of a single, coherent, multi-petal macro-structure. This alternative conceptualization may influence the designs of numerical models and image-reconstruction methods. Full article

This review systematizes information about the metabolic features of breast cancer directly related to oxidative stress. It has been shown those redox changes occur at all levels and affect many regulatory systems in the human body. The features of the biochemical processes occurring in breast cancer are described, ranging from nonspecific, at first glance, and strictly biochemical to hormone-induced reactions, genetic and epigenetic regulation, which allows for a broader and deeper understanding of the principles of oncogenesis, as well as maintaining the viability of cancer cells in the mammary gland. Specific pathways of the activation of oxidative stress have been studied as a response to the overproduction of stress hormones and estrogens, and specific ways to reduce its negative impact have been described. The diversity of participants that trigger redox reactions from different sides is considered more fully: glycolytic activity in breast cancer, and the nature of consumption of amino acids and metals. The role of metals in oxidative stress is discussed in detail. They can act as both co-factors and direct participants in oxidative stress, since they are either a trigger mechanism for lipid peroxidation or capable of activating signaling pathways that affect tumorigenesis. Special attention has been paid to the genetic and epigenetic regulation of breast tumors. A complex cascade of mechanisms of epigenetic regulation is explained, which made it possible to reconsider the existing opinion about the triggers and pathways for launching the oncological process, the survival of cancer cells and their ability to localize. Full article

Methane emissions from flooded rice paddies are a major source of atmospheric methane and represent a significant greenhouse gas with high climate-forcing potential due to anthropogenic activities globally. For sustainable agriculture, it is necessary to find effective methods for mitigating greenhouse gas emissions without reducing crop productivity. We investigated mechanisms to reduce methane emissions during rice cultivation by applying rice straw, rice husk biochar, humic acid, and a humic acid–iron complex, assessing greenhouse gases and rice yield over a single season. The results demonstrated that the treatment plots with rice straw and the humic acid–iron complex significantly reduced methane emissions (563 ± 113.9 kg ha⁻¹) by 34.4% compared to plots treated with rice straw alone (859 ± 126.4 kg ha⁻¹). Rice yield was not compromised compared to the control group treated with only NPK fertilizer, and growth in terms of plant height and tiller number was enhanced in the plots treated with rice straw and the humic acid–iron complex. Conversely, the plots treated solely with rice husk biochar and humic acid did not show a methane reduction effect when compared to the NPK treatment. The humic acid–iron complex has demonstrated potential as a methane mitigation agent with practical applicability in the field, warranting further long-term studies to validate its effectiveness. Full article

The advancement of photovoltaic module (PV) enhancer technology shows significant promise due to its rapid growth. Nevertheless, there remains a requirement for ongoing research to refine the evaluation techniques for this technology. In a prior investigation, the concept of the area and cost-effectiveness factor, denoted as ${\mathrm{F}}_{\mathrm{C}\mathrm{A}\mathrm{E}}$, was introduced to analyze the economic impact of enhancing the PV through techniques such as reflectors or coolers. This metric relates the surface area and manufacturing expenses of a PV enhancer to its capacity for improving the PV output power, aiding in the comparison of different enhancer types. However, this assessment approach is costly, requiring a set of PVs without enhancers to be compared with an equal number of modules fitted with enhancers. This paper introduces a modified version of this metric, termed the modified area and cost-effectiveness factor (${\mathrm{F}}_{\mathrm{M}\mathrm{C}\mathrm{A}\mathrm{E}}$), along with its minimum value (${\mathrm{F}}_{\mathrm{M}\mathrm{C}\mathrm{A}\mathrm{E},\min }$), with the aim of reducing the assessment expenses associated with PV enhancers. This modification hinges on knowing the output power from a single solar cell without an enhancer, as well as from a PV with an enhancer containing a known number of solar cells. Additionally, it relies on data regarding the manufacturing cost of the PV enhancer, the cost of one watt of PV power, and the combined surface area of the PV and its enhancer. The equations for computing the total number of solar cells and the associated costs in addition to the expenses cost are also proposed for ${\mathrm{F}}_{\mathrm{CAE}}$ and ${\mathrm{F}}_{\mathrm{MCAE}}$. The results of the present study using ${\mathrm{F}}_{\mathrm{MCAE}}$ show that there is a proportional relationship between the percentage of solar cell saving and the number of solar cells. As the solar cells increase, the percentage of solar sell saving increases. The findings reveal that utilizing ${\mathrm{F}}_{\mathrm{MCAE}}$ leads to a 48.33% increase in the proportion of solar cells saved compared to the existing method. It can be concluded that the proposed method is cost-efficient and holds promise for adoption by PV enhancer designers and manufacturers. Full article

This research investigates the optimal integration of Blockchain Technology (BT) in Supply Chain Management (SCM) within Chile’s maritime ports. Utilizing fuzzy Logarithmic Methodology of Additive Weights (LMAW) and Double Normalization-based Multiple Aggregation Methods (DNMA), the study systematically identifies, prioritizes, and ranks key factors influencing BT adoption in SCM. The study’s findings highlight crucial factors like enhanced transaction security, good supply chain practices, and risk management. Furthermore, it ranks the application of ports as prime candidates for BT integration. The research contributes theoretically by developing a hybrid model combining MCDA methods, and practically by guiding the strategic application of BT in the maritime logistics sector, aligning with the principles of Industry 5.0. This paper presents a novel approach that explores the utilization of BT in maritime supply chain management, incorporating MCDA in a vague environment. The research gap of this study lies in defining new contexts in both theoretical and practical literature reviews for extending the use of BT in SCM in the ports of Chile, according to Industry 5.0, to increase the efficiency and effectiveness of all aspects of operations in these places. The contribution of this research is applying hybrid MCDA methods in an uncertain environment to assist decision-makers (DMs) in better implementing BT in SCM in Chilean ports, according to Industry 5.0. Full article

In recent times, with rapid development in the construction sector, the use of enormous amounts of materials is required for the production of concrete. Fire penetrates concrete, leading to chemical contamination, small cracks, and lightening. These effects can significantly change the properties of concrete’s structure, reduce its strength and durability, and also change the behavior of the structure and lead to effects on the environment. An attempt was made to study the effects of elevated temperature on the mechanical characteristics of self-compacting concrete (SCC) with by-products including fly ash as a partial replacement for cement and waste copper slag as a partial replacement for fine aggregate at 0%, 10%, 20%, 30%, 40%, 50%, 60%, and 70%. The SCC specimens were subjected to elevated temperatures ranging from 200, 400, 600, and 800 °C, respectively, for a steady-state of two hours in a digital muffle furnace. The residual compressive strength, mass loss, ultrasonic pulse velocity, and residual density along with a visual inspection of cracks and color changes were observed. In this study, with over 400 °C temperatures, surface fractures appeared. The residual compressive strength (R-CMS) of all the individual temperatures of the SCC-WCS% mixes exhibited a gain in strength range from 31 to 34 MPa at 400 °C, 26 to 35 MPa at 600 °C, and 22.5 MPa to 33.5 MPa at 800 °C, respectively. Microstructural analysis of SCC-WCS% mixtures subjected to elevated ambient temperatures is carried out with a scanning electron microscope (SEM) and X-ray diffraction (XRD). Full article

In this paper, an enhanced VARTM process is proposed and its pressure effect on resin infusion behavior and composite material performance is studied to reveal the control mechanism of the fiber volume fraction and void content. The molding is vacuumized during the resin injection stage while it is pressurized during the mold filling and curing stages via a VARTM pressure control system designed in this paper. Theoretical calculations and simulation methods are used to reveal the resin’s in-plane, transverse, and three-dimensional flow patterns in multi-layer media. For typical thin-walled components, the infiltration behavior of resin in isotropic porous media is studied, elucidating the control mechanisms of fiber volume fraction and void content. The experiments demonstrate that the enhanced VARTM process significantly improves mold filling efficiency and composite’s performance. Compared to the regular VARTM process, the panel thickness is reduced by 4% from 1.7 mm, the average tensile strength is increased by 7.3% to 760 MPa, the average flexural strength remains at approximately 720 MPa, porosity is decreased from 1.5% to below 1%, and the fiber volume fraction is increased from 55% to 62%. Full article

(1) Background: We reviewed a stem cell-derived therapeutic strategy for advanced neovascular age-related macular degeneration (nAMD) using a human embryonic stem cell-derived retinal pigment epithelium (hESC-RPE) monolayer delivered on a coated, synthetic basement membrane (BM)—the patch—and assessed the presence and distribution of hESC-RPE over 5 years following transplantation, as well as functional outcomes. (2) Methods: Two subjects with acute vision loss due to sub-macular haemorrhage in advanced nAMD received the hESC-RPE patch. Systematic immunosuppression was used peri-operatively followed by local depot immunosuppression. The subjects were monitored for five years with observation of RPE patch pigmentation, extension beyond the patch boundary into surrounding retina, thickness of hESC-RPE and synthetic BM and review for migration and proliferation of hESC-RPE. Visual function was also assessed. (3) Results: The two study participants showed clear RPE characteristics of the patch, preservation of some retinal ultrastructure with signs of remodelling, fibrosis and thinning on optical coherence tomography over the 5-year period. For both participants, there was evidence of pigment extension beyond the patch continuing until 12 months post-operatively, which stabilised and was preserved until 5 years post-operatively. Measurement of hESC-RPE and BM thickness over time for both cases were consistent with predefined histological measurements of these two layers. There was no evidence of distant RPE migration or proliferation in either case beyond the monolayer. Sustained visual acuity improvement was apparent for 2 years in both subjects, with one subject maintaining the improvement for 5 years. Both subjects demonstrated initial improvement in fixation and microperimetry compared to baseline, at year 1, although only one maintained this at 4 years post-intervention. (4) Conclusions: hESC-RPE patches show evidence of continued pigmentation, with extension, to cover bare host basement membrane for up to 5 years post-implantation. There is evidence that this represents functional RPE on the patch and at the patch border where host RPE is absent. The measurements for thickness of hESC-RPE and BM suggest persistence of both layers at 5 years. No safety concerns were raised for the hypothetical risk of RPE migration, proliferation or tumour formation. Visual function also showed sustained improvement for 2 years in one subject and 5 years in the other subject. Full article

The genus Phlomis is one of the largest genera in the Lamiaceae family and includes species used since ancient times in traditional medicine, as flavoring for food and as fragrance in cosmetics. The secretory structures (represented by glandular trichomes) as well as the essential oils produced by them constitute the subject of this review. While representatives of this genus are not typically regarded as large producers of essential oils compared to other species of the Lamiaceae family, the components identified in their essential oils and their biological properties necessitate more investigation of this genus. A comprehensive analysis of the specialized literature was conducted for each of the 93 currently accepted species to identify all the results obtained by researchers regarding the secretory structures and essential oils of this genus up to the present time. Glandular trichomes, still insufficiently studied, present morphological peculiarities that differentiate this genus within the family: they are of two categories: capitate (with a wide distribution in this genus) and dendroid. The peltate trichomes, characteristic of many species of this family, are absent. The essential oils from the species of the genus Phlomis have been much more widely studied than the secretory structures. They show considerable variability depending on the species and the environmental conditions. Full article

The antibacterial and anti-inflammatory effect of thioglycosides has already been established. This study investigates the effects of thioglycosides extracted from white mustard, specifically the “Bamberka” variety, in the context of oral hygiene. The aim of the study is to clarify an evidence-based link between the documented antibacterial and anti-inflammatory effects attributed to thioglycosides and their practical application in oral care. A randomized, single-blinded (patient-blinded) clinical study was performed on 66 patients using mustard-based toothpaste for oral hygiene. The patients were examined at baseline and after 6 and 12 months. The values of the Approximal Plaque Index (API), the Plaque Index (PI), and Bleeding on probing (BOP) were taken into consideration. The results show a significant reduction in plaque accumulation, especially after 6 months of using mustard-based toothpaste in all examined parameters. This suggests that thioglycosides from mustard contribute to a considerable decrease in dental plaque accumulation, confirming their potential in natural oral care solutions, which is indicated in the main conclusions or interpretations. Full article

The aim of this study is to produce a biodegradable food packaging material that reduces environmental pollution and protects food safety. The effects of total solids content, substrate ratio, polyphenol content, and magnetic stirring time on bovine bone gelatin/sodium carboxymethylcellulose nanoemulsion (BBG/SCMC–NE) were investigated using particle size, PDI, turbidity, rheological properties, and zeta potential as evaluation indexes. The micro, structural, antioxidant, encapsulation, and release properties were characterized after deriving its optimal preparation process. The results showed that the nanoemulsion was optimally prepared with a total solids content of 2%, a substrate ratio of 9:1, a polyphenol content of 0.2%, and a magnetic stirring time of 60 min. SEM showed that the nanoemulsion showed a dense and uniform reticulated structure. FTIR and XRD results showed that covalent cross-linking of proteins and polysaccharides altered the structure of gelatin molecular chains to a more compact form but did not change its semi-crystalline structure. DSC showed that the 9:1 BBG/SCMC–NE had a higher thermal denaturation temperature and greater thermal stability, and its DPPH scavenging rate could reach 79.25% and encapsulation rate up to 90.88%, with excellent slow-release performance. The results of the study provide basic guidance for the preparation of stable active food packaging with excellent properties. Full article

The high complexity of the parameter–simulation problem in land surface models over semiarid areas makes it difficult to reasonably estimate the surface simulation conditions that are important for both weather and climate in different regions. In this study, using the dense site datasets of a typical semiarid region over Tibet and the Noah land surface model with the constrained land parameters of multiple sites, an enhanced Kling–Gupta efficiency criterion comprising multiple objectives, including variable and layer dimensions, was obtained, which was then applied to calibration schemes based on two global search algorithms (particle swarm optimization and shuffled complex evaluation) to investigate the site-scale spatial complexities in soil temperature simulations. The calibrations were then compared and further validated. The results show that the Noah land surface model obtained reasonable simulations of soil moisture against the observations with fine consistency, but the negative fit and huge spatial errors compared with the observations indicated its weak ability to simulate the soil temperature over regional semiarid land. Both calibration schemes significantly improved the soil moisture and temperature simulations, but particle swarm optimization generally converged to a better objective than shuffled complex evaluation, although with more parameter uncertainties and less heterogeneity. Moreover, simulations initialized with the optimal parameter tables for the calibrations obtained similarly sustainable improvements for soil moisture and temperature, as well as good consistency with the existing soil reanalysis. In particular, the soil temperature simulation errors for particle swarm optimization were unbiased, while those for the other method were found to be biased around −3 K. Overall, particle swarm optimization was preferable when conducting soil temperature simulations, and it may help mitigate the efforts in surface forecast improvement over semiarid regions. Full article

Soccer athletic performance varies across a soccer season due to training and fatigue. In addition, it is known that core stability is linked with anterior cruciate ligament (ACL) injury risk but their variations over a season are unknown. The aim of the study was to determine the evolution of core stability, athletic performance, and ACL injury risk among young high-level soccer players at four key moments of a season: pre-season (PRE), start of season (START), mid-season (MID), and the end of the season (END). Core stability scores increased until mid-season, while ACL injury risk scores (measured during sidestep cuttings and single-leg landing) decreased thanks to an injury prevention program between START and MID. These results are in line with the literature, which demonstrates that a high level of core stability is linked to a low injury risk. Evolution of athletic performance was not consistent throughout the season, being dependent on the specific phases of training performed by the athletes. Therefore, assessing core stability, athletic performance, and ACL injury risk multiple times across a soccer season could help coaches to adapt their training programs properly. Full article

Assessing indoor environmental quality (IEQ) is fundamental to ensuring health, well-being, and safety. A particular type of indoor compartment, land transport cabins (LTCs), specifically those of trains and buses, was surveyed. The global rise in commute and in-cabin exposure time gives relevance to the current study. This study discusses indoor climate (IC) in LTCs to emphasize the risk to the well-being and comfort of exposed occupants linked to poor IEQ, using objective assessment and a communication method following recommendations of the CEN-EN16798-1 standard. The measurement campaign was carried out on 36 trips of real-time travel on 15 buses and 21 trains, mainly in the EU region. Although the measured operative temperature, relative humidity, CO₂, and VOC levels followed EN16798-1 requirements in most cabins, compliance gaps were found in the indoor climate of these LTCs as per ventilation requirements. Also, the PMV-PPD index evaluated in two indoor velocity ranges of 0.1 and 0.3 m/s showed that 39% and 56% of the cabins, respectively, were thermally inadequate. Also, ventilation parameters showed that indoor air quality (IAQ) was defective in 83% of the studied LTCs. Therefore, gaps exist concerning the IC of the studied LTCs, suggesting potential risks to well-being and comfort and the need for improved compliance with the IEQ and ventilation criteria of EN16798-1. Full article

The challenge of denoising low-dose computed tomography (CT) has garnered significant research interest due to the detrimental impact of noise on CT image quality, impeding diagnostic accuracy and image-guided therapies. This paper introduces an innovative approach termed the Wavelet Domain Dual Forward Denoising Stream Network (WaveletDFDS-Net) to address this challenge. This method ingeniously combines convolutional neural networks and Transformers to leverage their complementary capabilities in feature extraction. Additionally, it employs a wavelet transform for efficient image downsampling, thereby preserving critical information while reducing computational requirements. Moreover, we have formulated a distinctive dual-domain compound loss function that significantly enhances the restoration of intricate details. The performance of WaveletDFDS-Net is assessed by comparative experiments conducted on public CT datasets, and results demonstrate its enhanced denoising effect with an SSIM of 0.9269, PSNR of 38.1343 and RMSE of 0.0130, superior to existing methods. Full article

Failure mode and effects analysis (FMEA) helps to identify the weak points in the processing, manufacturing, and assembly of products and plays an important role in improving product reliability. To address the shortcomings of the existing FMEA methods in terms of the uncertainty treatment of information and not considering the weights and correlations between risk factors, we propose a new FMEA method. In this paper, the Fermatean fuzzy Z-number (FFZN) is proposed by fusing the Fermatean fuzzy number and Z-number. Extending it to the Bonferroni mean (BM) operator, the Fermatean fuzzy Z-number-weighted Bonferroni mean (FFZWBM) operator is proposed. A new FMEA method is proposed based on this operator. In order to overcome the factors not considered in the FMEA method, two new risk factors are proposed and added. The ability of experts to express fuzzy information is enhanced by introducing the FFS. The weights and correlations between the influencing factors can be handled by aggregating the evaluation information using the FFZWBM operator. Finally, the proposed method is applied to an arithmetic example and the accuracy of the proposed method is proved by teaming it with other methods. Full article

Despite the large number of existing varieties of Vitis vinifera L., only few occupy a large niche in today’s highly globalized wine market. The increasing consumer demand for diversified products, as well as the changing climatic conditions, make establishing a process of varietal diversification essential to achieve both challenges. It is for this reason that the study of minority varieties, which have a higher level of adaptation to each area of origin, is of particular interest. With the main objective of achieving an in-depth knowledge of minority varieties in Spain, the national research project ‘Valorization of Minority Grapevine Varieties for their Potential for Wine Diversification and Resilience to Climate Change’ (MINORVIN), has been proposed. Within this extensive project, the present study describes the aroma profiles of 60 single-variety wines, corresponding with 44 different varieties, with 12 of these varieties being studied at the same time in several Spanish regions. Volatile compounds were determined through three consecutive vintages using gas chromatography-mass spectrometry (GC-MS) and gas chromatography–flame ionization detector (GC-FID). Compounds were grouped into major compounds, including alcohols, C₆ compounds, esters, acetates, acids, carbonyl compounds, and other type of compounds, and minor compounds, including lactones, terpenes, and C₁₃-norisoprenoids, according to their concentration in the wines being analyzed. Among this last group of compounds, lactones were quantitatively the most abundant, followed by terpenes. This study reflects that minority variety wines show distinctive aromatic profiles, supporting the importance of valuing and promoting the autochthonous minority grapevine varieties for the Spanish winemaking industry. Full article

Underwater gliders have emerged as effective tools for long-term ocean exploration. Employing aircraft for launching underwater gliders could significantly expand their application. Compared to slender underwater vehicles, the distinctive wing structure of underwater gliders may endure huge impact forces when entering water, leading to more intricate impact load characteristics and potential wing damage. This paper employs a computational fluid dynamics approach to analyze the water entry event of an airdropped underwater glider and its impact load behavior. The results indicate that the glider impact load is enhanced prominently by the wing, and that the extent of enhancement is influenced by the entry attitude. At an entry angle of 80°, the glider exhibits the maximum impact load during different water entry angles. In addition, a larger attack angle indicates a higher glider impact load. Our present study holds significant importance for both the hydrodynamic shape design and water entry strategy control of airdropped underwater gliders. Full article

To investigate the dissolution mechanism of Ti metal, ab initio calculations were conducted to observe the impact of Ti vacancy defects on the O-adsorbed Ti(0001) surface, focusing on the formation energies of Ti vacancy, geometric structures, and electronic structures. The surface structures subsequent to Ti dissolution were simulated by introducing a Ti cavity on both clean and O-adsorbed Ti(0001) surfaces. Our findings indicated that Ti vacancy formation energies and electrochemical dissolution potential on the O-adsorbed Ti(0001) surface surpassed those on the clean surface, and they increased with increasing O coverage. This suggested that O adsorption inhibited Ti dissolution and enhanced O atom interaction with the Ti surface as O coverage increased. Furthermore, at higher O coverage, Ti vacancies contributed to the strengthening of Ti-O bonds on the O-adsorbed Ti(0001) surface, indicating that Ti dissolution aided in stabilizing the Ti surface. The formation of Ti vacancies brought the atomic ratio of Ti to O on the Ti surface closer to that of TiO₂, potentially explaining the increased stability of the structure with Ti vacancies. Full article