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The control of irrigation volume is of significant importance in arid regions of northwest China. Particularly, it has a crucial impact on the salinization of shallow groundwater areas. In 2022 and 2023, field experiments were conducted to test three distinct under-membrane irrigation treatments.
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The control of irrigation volume is of significant importance in arid regions of northwest China. Particularly, it has a crucial impact on the salinization of shallow groundwater areas. In 2022 and 2023, field experiments were conducted to test three distinct under-membrane irrigation treatments. These treatments were assigned water quotas of HW (27 mm), MW (22.5 mm), and LW (18 mm). The HYDRUS-2D model was integrated with a field experiment to accurately simulate the dynamic fluctuations of soil water and salt in the sunflower root zone. The model’s performance was assessed and verified using real-field data from 2022 and 2023, and the simulation results closely matched the measured values. This research also used stable hydroxide isotopes to assess the water supply from various soil layers at different time intervals in sunflower plants. The results indicated that the three different levels of irrigation applied under the membrane had a significant impact on soil water content. Specifically, there was a significant difference in soil water content at a depth of 0–40 cm (p <0.05), while there was little effect on the water content at a depth of 40–60 cm (p >0.05). After irrigation, the average salt content in the top 0–20 cm of soil decreased by 7.0% compared to the medium and low irrigation levels, and by 10.8% compared to the medium irrigation level. Additionally, the medium irrigation level resulted in a 10.8% decrease in salt content compared to the low irrigation level, and a 4.1% decrease compared to the medium irrigation level. During the same period, the soil salinity levels at depths of 0–20 cm, 20–40 cm, 40–60 cm, and 60–100 cm in the area outside the membrane were measured to be 2.7~4.8 g·kg−1, 2.8~4.0 g·kg−1, 2.7~3.4 g·kg−1, and 1.7~2.6 g·kg−1, respectively. These levels decreased by 13.1~55.5%, 0.7~42.8%, −0.4~16.2%, and −72.7~7.5%, respectively. Following irrigation, the HW treatment mostly absorbed water in the 0–40 cm soil layer, while the MW and LW treatments absorbed water in both the 0–40 cm and 60–80 cm soil levels. The results indicated that the most optimal drip irrigation method beneath the membrane in this location was achieved when the amount of water applied was between 25–30 mm. This method demonstrated a combination of water conservation, high crop yield, and effective salt suppression.
Full article
The long-term record of ecological, limnological and climatological parameters that were documented in the Kinneret drainage basin was statistically evaluated. The dependent relations between environmental parameters and a change in climate conditions open a consequence dispute between three optional definitions: long-term instability, climate
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The long-term record of ecological, limnological and climatological parameters that were documented in the Kinneret drainage basin was statistically evaluated. The dependent relations between environmental parameters and a change in climate conditions open a consequence dispute between three optional definitions: long-term instability, climate change impact and ecosystem resiliency. The Kinneret drainage basin during the Anthropocene era is marked by intensive anthropogenic involvement: Increase in population size, drainage of the wetlands and old lake Hula, agricultural development, enhancement of lake Kinneret utilization for water supply, hydrological management, fishery and recreation. Therefore, the impact of a combination of natural and anthropogenic environmental factors confounded each other, and the uniqueness of climate change is unclear.
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Maria Laura Sollini, Chiara Pellegrino, Giulia Barone, Maria Luisa Capitanucci, Antonio Maria Zaccara, Leonardo Crescentini, Enrico Castelli, Gessica Della Bella, Federico Scorletti, Laura Papetti, Gabriele Monte, Michela Ada Noris Ferilli, Massimiliano Valeriani and Giovanni Mosiello
Children2024, 11(5), 601; https://doi.org/10.3390/children11050601 (registering DOI) - 16 May 2024
Background: Multiple sclerosis (MS) is increasing in the pediatric population and, as in adults, symptoms vary among patients. In children the first manifestations can sometimes overlap with acute neurological symptoms. Urological symptoms have not been much studied in childhood. We shared our experience
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Background: Multiple sclerosis (MS) is increasing in the pediatric population and, as in adults, symptoms vary among patients. In children the first manifestations can sometimes overlap with acute neurological symptoms. Urological symptoms have not been much studied in childhood. We shared our experience with MS urological manifestation in children. Methods: This article is a retrospective evaluation of all children with MS, according to the Krupp criteria, who also present with urological symptoms. We collected demographic and clinical history, the MR localization of demyelinating lesions, urological symptoms, and exams. Results: We report on six MS pediatric cases with urological manifestation. Urinary symptoms, characterized by urinary incontinence in five patients and urinary retention in one patient, appeared in a different time frame from MS diagnosis. Urodynamic exams showed both overactive and underactive bladder patterns. Treatment was defined according to lower urinary tract dysfunction, using clean intermittent catheterization, oxybutynin, and intradetrusor Onabotulinum Toxin-A injection. A low acceptance rate of invasive evaluation and urological management was observed. Conclusions: The MS diagnosis was traumatic for all our patients. We believe it is important to address urological care in young people from the time of diagnosis for prompt management; it could be useful to include a pediatric urologist in multidisciplinary teams.
Full article
The combination of anti-angiogenesis agents with immune-checkpoint inhibitors is a promising treatment for patients with advanced hepatocellular carcinoma (HCC); however, therapeutic resistance caused by cancer stem cells present in tumor microenvironments remains to be overcome. In this study, we report for the first
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The combination of anti-angiogenesis agents with immune-checkpoint inhibitors is a promising treatment for patients with advanced hepatocellular carcinoma (HCC); however, therapeutic resistance caused by cancer stem cells present in tumor microenvironments remains to be overcome. In this study, we report for the first time that the Kringle 1 domain of human hepatocyte growth-factor α chain (HGFK1), a previously described anti-angiogenesis peptide, repressed the sub-population of CD90+ cancer stem cells (CSCs) and promoted their differentiation and chemotherapy sensitivity mainly through downregulation of pre-Met protein expression and inhibition of Wnt/β-catenin and Notch pathways. Furthermore, we showed that the i.p. injection of PH1 (a tumor-targeted and biodegradable co-polymer), medicated plasmids encoding Endostatin (pEndo), HGFK1 genes (pEndo), and a combination of 50% pEndo + 50% pHGFK1 all significantly suppressed tumor growth and prolonged the survival of the HCC-bearing mice. Importantly, the combined treatment produced a potent synergistic effect, with 25% of the mice showing the complete clearance of the tumor via a reduction in the microvessel density (MVD) and the number of CD90+ CSCs in the tumor tissues. These results suggest for the first time that HGFK1 inhibits the CSCs of HCC. Furthermore, the combination of two broad-spectrum anti-angiogenic factors, Endo and HGFK1, is the optimal strategy for the development of effective anti-HCC drugs.
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In an era focused on deepening green sustainable development, improving corporate ESG performance has become a theoretical focal point. Starting from the positional attributes of the interlocking director network, this study investigates the influence of a company’s position within this network on its
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In an era focused on deepening green sustainable development, improving corporate ESG performance has become a theoretical focal point. Starting from the positional attributes of the interlocking director network, this study investigates the influence of a company’s position within this network on its ESG performance among China’s A-share-listed companies from 2009 to 2022. It utilizes Huazheng ESG ratings from the Wind database and employs regression models, analyses, endogeneity, and propensity score matching tests via Stata15.0 to probe the internal mechanisms at play. Research findings indicate that corporations at the core of the interlocking director network exhibit significantly better ESG performance compared to those in peripheral positions. The interlocking director network enhances corporate ESG performance by improving internal control levels. Media attention positively influences the effect of the interlocking director network on corporate ESG performance. Further analysis reveals that the beneficial impact of the interlocking director network on ESG performance is more pronounced in highly marketized corporations, those outside of heavy pollution industries, and those with a higher proportion of female directors. Economically, the positive effect of the interlocking director network on ESG performance enhances both earnings per share and total factor productivity. This study offers a novel pathway for enhancing corporate sustainability in emerging economies through the lens of the interlocking director network, drawing on China’s experience. It aims to guide emerging markets in fostering ESG practices among corporations, thus offering theoretical insights for enhancing ESG performance.
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This review focuses on the emerging evidence for the association between non-exercise fitness testing, estimated cardiorespiratory fitness (eCRF), and metabolic risk factors. Given the challenges associated with directly measuring cardiorespiratory fitness (CRF) in large populations, eCRF presents a practical alternative for predicting metabolic
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This review focuses on the emerging evidence for the association between non-exercise fitness testing, estimated cardiorespiratory fitness (eCRF), and metabolic risk factors. Given the challenges associated with directly measuring cardiorespiratory fitness (CRF) in large populations, eCRF presents a practical alternative for predicting metabolic health risks. A literature search identified seven relevant cohort studies from 2020 to 2024 that investigated the association of eCRF with hypertension, hyperglycemia, dyslipidemia, and obesity. This review consistently demonstrates an inverse relationship between higher eCRF and a lower incidence of metabolic risks, which is in line with CRF cohort studies. It highlights the importance of low eCRF as a primordial indicator for metabolic risks and underscores the potential for broader application. Future research directions should include exploring eCRF’s predictive ability across diverse populations and health outcomes and testing its real-world applicability in healthcare and public health settings.
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Various conjugates with rhodamines were prepared by starting with betulinic acid (BA) and platanic acid (PA). The molecules homopiperazine and piperazine, which were identified in earlier research, served as linkers between the rhodamine and the triterpene. The pentacyclic triterpene’s
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Various conjugates with rhodamines were prepared by starting with betulinic acid (BA) and platanic acid (PA). The molecules homopiperazine and piperazine, which were identified in earlier research, served as linkers between the rhodamine and the triterpene. The pentacyclic triterpene’s ring A was modified with two acetyloxy groups in order to possibly boost its cytotoxic activity. The SRB assays’ cytotoxicity data showed that conjugates 13–22, derived from betulinic acid, had a significantly higher cytotoxicity. Of these hybrids, derivatives 19 (containing rhodamine B) and 22 (containing rhodamine 101) showed the best values with EC50 = 0.016 and 0.019 μM for A2780 ovarian carcinoma cells. Additionally, based on the ratio of EC50 values, these two compounds demonstrated the strongest selectivity between malignant A2780 cells and non-malignant NIH 3T3 fibroblasts. A375 melanoma cells were used in cell cycle investigations, which showed that the cells were halted in the G1/G0 phase. Annexin V/FITC/PI staining demonstrated that the tumor cells were affected by both necrosis and apoptosis.
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In the midst of China’s ongoing rural–urban integration and development, a pivotal transformation involving the realignment of labour dynamics and land utilisation is underway. This paradigm shift has substantial implications for rural land use and agricultural productivity. Drawing from the field survey conducted
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In the midst of China’s ongoing rural–urban integration and development, a pivotal transformation involving the realignment of labour dynamics and land utilisation is underway. This paradigm shift has substantial implications for rural land use and agricultural productivity. Drawing from the field survey conducted in Zhejiang Province in 2019, this study puts non-agricultural employment, land transfer, and land efficiency into one econometric model and establishes a comprehensive framework to explain the mechanisms. Unlike existing research, this paper delves into the impact of different land-transfer behaviours, namely inflow and outflow, on land efficiency. The findings indicate that non-agricultural employment has no significant impact on land efficiency. Rural households acquiring land significantly enhance land efficiency, whereas relinquishing land shows no significance, thus addressing the gap in existing literature regarding the study of different transfer behaviours. Furthermore, to explore the underlying mechanisms, we investigate the mediating effect of land inflows on land efficiency, finding that it operates through plot size. In light of this, we propose that, in guiding land inflows, more emphasis should be placed on the integration and reorganisation of fragmented land rather than simply expanding the total land area, aiming to create large, well-managed areas of arable land by achieving concentrated and contiguous transferable land parcels.
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Background: Allergen immunotherapy remains a widely recognized and widely used method for the treatment of selected allergic diseases. Currently, according to the European Academy Of Allergy and Clinical Immunology (EAACI) guidelines, venom immunotherapy (VIT) may be considered for patients over 60. Nevertheless, no
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Background: Allergen immunotherapy remains a widely recognized and widely used method for the treatment of selected allergic diseases. Currently, according to the European Academy Of Allergy and Clinical Immunology (EAACI) guidelines, venom immunotherapy (VIT) may be considered for patients over 60. Nevertheless, no separate studies have confirmed the efficacy and safety of this therapy. This study aimed to evaluate the short-term effectiveness of VIT against wasp allergens in an ultra-rush protocol for older patients compared to young patients. Methods: Among the 113 patients included in this study, 51 were older than 60 years (Group A), and 62 formed the control “young group” (age range: 18–35 years). All patients were desensitized to wasp venom using the ultra-rush protocol according to Muller and aqueous solutions of vaccines containing wasp venom. A basophil activation test (Basotest, Orpegen Pharma, Germany) and intracutaneous tests with dilutions of wasp allergen and specific IgE to extract wasp venom were performed at the start and after six months of VIT. The safety of VIT was assessed on the basis of the international Mueller scale. Results: One hundred and eleven patients with confirmed wasp allergies completed six months of VIT: 51 participants over 60 years of age (Group A) and 60 young people (Group B). No systemic adverse reactions were observed during the VIT induction phase. However, large local reactions were noted in 17% of older patients and 20% of young patients at a similar level (p > 0.05). During maintenance VIT, two mild grade I systemic reactions were confirmed in young patients. These symptoms resolved spontaneously. There were no such reactions in older patients. The effectiveness of VIT was tested using BAT. There was a statistically significant reduction in CD63 reactivity in 86% of patients in Group A, and a comparable and substantial decrease in 84% of young patients in Group B. According to the BAT test, the mean reductions in the area under the curve (AUC) after six months of VIT were significant (p < 0.05) and comparable between Groups A and B: −6.52 vs. 7.21. Conclusions: VIT against wasp venom is safe and effective in short-term observation, and is comparable to that used for young patients.
Full article
Ancient trade routes significantly influenced political structures, cultural exchanges, economic development, and landscape transformations across diverse regions. The Ancient Tea Horse Road, a prominent historical commercial pathway in China, is crucial for ecosystem and cultural heritage conservations. This study uses content and comparative
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Ancient trade routes significantly influenced political structures, cultural exchanges, economic development, and landscape transformations across diverse regions. The Ancient Tea Horse Road, a prominent historical commercial pathway in China, is crucial for ecosystem and cultural heritage conservations. This study uses content and comparative analysis, Geographic Information System (GIS) technology, and spatial analysis to examine the spatiotemporal relationships between 13,026 settlement points identified via Google Earth and 445 recorded settlement names within the Dali Bai Autonomous Prefecture, Yunnan Province. The findings indicate that the Ancient Tea Horse Road evolved from a simple linear form to a complex radial network, reflecting its growth from local to broad regional connectivity. Settlements related to administrative, postal, and commercial functions emerged in its vicinity, underscoring the route’s impact on social structures and economic activities. The development of settlements, mainly within a 10 km radius of the route, was closely linked to its expansion, alteration, and decline, offering insights into contemporary settlement distribution patterns. This research not only enhances the understanding of the Ancient Tea Horse Road and its surrounding settlements but also supports the protection of ancient trade routes and their cultural heritage. It contributes to sustainable development by integrating ecological preservation with the safeguarding of ancient trade routes and their cultural legacies.
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Sweetness in food delivers a delightful sensory experience, underscoring the crucial role of sweeteners in the food industry. However, the widespread use of sweeteners has sparked health concerns. This underscores the importance of developing and screening natural, health-conscious sweeteners. Our study represents a
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Sweetness in food delivers a delightful sensory experience, underscoring the crucial role of sweeteners in the food industry. However, the widespread use of sweeteners has sparked health concerns. This underscores the importance of developing and screening natural, health-conscious sweeteners. Our study represents a groundbreaking venture into the discovery of such sweeteners derived from egg and soy proteins. Employing virtual hydrolysis as a novel technique, our research entailed a comprehensive screening process that evaluated biological activity, solubility, and toxicity of the derived compounds. We harnessed cutting-edge machine learning methodologies, specifically the latest graph neural network models, for predicting the sweetness of molecules. Subsequent refinements were made through molecular docking screenings and molecular dynamics simulations. This meticulous research approach culminated in the identification of three promising sweet peptides: DCY(Asp-Cys-Tyr), GGR(Gly-Gly-Arg), and IGR(Ile-Gly-Arg). Their binding affinity with T1R2/T1R3 was lower than −15 kcal/mol. Using an electronic tongue, we verified the taste profiles of these peptides, with IGR emerging as the most favorable in terms of taste with a sweetness value of 19.29 and bitterness value of 1.71. This study not only reveals the potential of these natural peptides as healthier alternatives to traditional sweeteners in food applications but also demonstrates the successful synergy of computational predictions and experimental validations in the realm of flavor science.
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Zainab Dahrouch, Giuliana Malta, Moreno d’Ambrosio, Angelo Alberto Messina, Mattia Musolino, Alessandro Sitta, Michele Calabretta and Salvatore Patanè
Micro-Raman spectroscopy was carried out to evaluate the localized residual stresses in commercial Gallium-Nitride-based devices, specifically, AlGaN/GaN high-electron-mobility Transistors (HEMTs) with a novel packaging design provided by STMicroelectronics S.r.l. (Catania, Italy). The packaging plays a key role in protecting the device core against
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Micro-Raman spectroscopy was carried out to evaluate the localized residual stresses in commercial Gallium-Nitride-based devices, specifically, AlGaN/GaN high-electron-mobility Transistors (HEMTs) with a novel packaging design provided by STMicroelectronics S.r.l. (Catania, Italy). The packaging plays a key role in protecting the device core against the external environment, thus minimizing damages caused by mechanical shocks, exposure to light, and contact with chemicals, conjointly achieving an efficient heat dissipation rate. Even though the packaging is a required step for the proper functioning of ready-to-use electronic devices, its application typically may introduce mechanical stress to AlGaN/GaN HEMTs, which can result in various reliability issues. In this paper, we investigate the impact of packaging on residual stress by analyzing the frequency shift of the E2 Raman peak along GaN layers and at the GaN/Si interface. An extensive evaluation was conducted using both a packaged device and a wafer-level device. The correlation between Raman frequency shifts of the E2 mode was accurately quantified, revealing a stress mitigation of approximately 0.1 GPa. This reduction is ascribed to the compressive stress introduced by the packaging, which partially offsets the intrinsic tensile stress of the wafer-level device. The proposed methodology could, in principle, be implemented to improve the development of packaging.
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In this paper, an analysis of existing models for describing surfaces of various types is performed, and the possibilities of their application at the level of mathematical modeling are analyzed. Moreover, due to the large number of models and the complexity of selecting
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In this paper, an analysis of existing models for describing surfaces of various types is performed, and the possibilities of their application at the level of mathematical modeling are analyzed. Moreover, due to the large number of models and the complexity of selecting the appropriate model, e.g., when conducting a practical experiment, an algorithm for choosing a specific model depending on the initial data is proposed. According to the algorithm, a software prototype that implements this algorithm (written in Python) is proposed.
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Pithiness is one of the physiological diseases of radishes, which is accompanied by the accumulation of reactive oxygen species (ROS) during the sponging of parenchyma tissue in the fleshy roots. A respiratory burst oxidase homolog (Rboh, also known as NADPH oxidase) is a
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Pithiness is one of the physiological diseases of radishes, which is accompanied by the accumulation of reactive oxygen species (ROS) during the sponging of parenchyma tissue in the fleshy roots. A respiratory burst oxidase homolog (Rboh, also known as NADPH oxidase) is a key enzyme that catalyzes the production of ROS in plants. To understand the role of Rboh genes in radish pithiness, herein, 10 RsRboh gene families were identified in the genome of Raphanus sativus using Blastp and Hmmer searching methods and were subjected to basic functional analyses such as phylogenetic tree construction, chromosomal localization, conserved structural domain analysis, and promoter element prediction. The expression profiles of RsRbohs in five stages (Pithiness grade = 0, 1, 2, 3, 4, respectively) of radish pithiness were analyzed. The results showed that 10 RsRbohs expressed different levels during the development of radish pithiness. Except for RsRbohB and RsRbohE, the expression of other members increased and reached the peak at the P2 (Pithiness grade = 2) stage, among which RsRbohD1 showed the highest transcripts. Then, the expression of 40 genes related to RsRbohD1 and pithiness were analyzed. These results can provide a theoretical basis for improving pithiness tolerance in radishes.
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Advancements in contact mechanics play an important role in the design of modern mechanical and bio-medical systems, enhancing their efficiency, power density, and reliability [...]
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Ejector-cleaning devices for abrasive jet machining have various practical applications. The working nozzle is one of the device’s key elements affecting the treated surface quality. There arises the necessity for new approaches to achieving an efficiency increase in abrasive jet equipment nozzles, namely
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Ejector-cleaning devices for abrasive jet machining have various practical applications. The working nozzle is one of the device’s key elements affecting the treated surface quality. There arises the necessity for new approaches to achieving an efficiency increase in abrasive jet equipment nozzles, namely their design improvement and further development of a new, relatively cheap but effective technology for their manufacturing and maintenance. This technology should allow for the high durability of nozzles without being essential for the hardness or wear resistance parameters of the material used for manufacturing. The nozzle should be designed as a long-length perforated insert to allow for radial airflow, forcing the abrasive material (river sand) from the inner walls of the nozzle’s working surface to reduce its friction with the abrasive material. This will result in new wear-out conditions, providing an essential decrease in the wear-out of a nozzle’s working surface. The article aims to develop a more effective design for the working nozzle based on the perforated insert application. The task was set to provide a more detailed experimental and theoretical study of the processes in perforated nozzles to improve their effectiveness. The research resulted in a new design for nozzles with higher efficiency.
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Egypt has the potential to generate a significant amount of energy from renewable technologies, in particular solar PV, concentrated solar power (CSP), and onshore and offshore wind. The energy sector is reliant on fossil fuels, particularly natural gas, for electricity production and is
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Egypt has the potential to generate a significant amount of energy from renewable technologies, in particular solar PV, concentrated solar power (CSP), and onshore and offshore wind. The energy sector is reliant on fossil fuels, particularly natural gas, for electricity production and is at risk of locking itself into a high carbon pathway. Globally, reducing greenhouse gas (GHG) emissions associated with national energy sectors is a target outlined in the UN’s Paris Agreement. To reduce carbon dioxide (CO2) emissions associated with a higher dependence on fossil fuels, Egypt must consider upscaling renewable energy technologies (RETs) to achieve a clean energy transition (CET). This research modelled six scenarios using clicSAND for OSeMOSYS to identify the technologies and policy target improvements that are needed to upscale RETs within Egypt’s energy sector. The results showed that solar PV and onshore wind are key technologies to be upscaled to contribute towards Egypt’s CET. The optimal renewable target is the International Renewable Energy Agency’s (IRENA) target of 53% of electricity being sourced from RETs by 2030, which will cost USD 16.4 billion more up to 2035 than Egypt’s current Integrated Sustainable Energy Strategy (ISES) target of 42% by 2035; it also saves 732.0 MtCO2 over the entire modelling period to 2070. Socio-economic barriers to this transition are considered, such as recent discoveries of natural gas reserves combined with a history of energy insecurity, political instability impacting investor confidence, and a lack of international climate funding. The paper concludes with policy recommendations that would enable Egypt to progress towards achieving a CET.
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The filling efficiency during the hot embossing process at micro scale is essential for micro-component replication. The presence of the unfilled area is often due to the inadequate behavior law applied to the embossed materials. This research consists of the identification of viscoplastic
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The filling efficiency during the hot embossing process at micro scale is essential for micro-component replication. The presence of the unfilled area is often due to the inadequate behavior law applied to the embossed materials. This research consists of the identification of viscoplastic law (two-layer viscoplastic model) of polymers and the optimization of processing parameters. Mechanical tests have been performed for two polymers at 20 °C and 30 °C above their glass transition temperature. The viscoplastic parameters are characterized based on stress–strain curves from the compression tests. The influences of imposed displacement, temperature, and friction on mold filling are investigated. The processing parameters are optimized to achieving the complete filling of micro cavities. The replication of a micro-structured cavity has been effectuated using this process and the experimental observations validate the results in the simulation, which confirms the efficiency of the proposed numerical approach.
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The developments in manufacturing technologies are expected to reduce energy input without compromising product quality. Regarding the material densification process, numerical simulation methods are applied to achieve this goal. In this case, relevant material models are built using functions that describe the variation
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The developments in manufacturing technologies are expected to reduce energy input without compromising product quality. Regarding the material densification process, numerical simulation methods are applied to achieve this goal. In this case, relevant material models are built using functions that describe the variation in mechanical parameters of the material in question due to its deformation. The literature review conducted for this research has revealed a shortage of experimental research methods allowing a determination of the coefficient of friction at low temperatures, approximately 200 K. This article proposes a method for determining the friction coefficient of dry ice sliding against steel. The experimental results were analysed to obtain several functions describing the variation in the coefficient of friction. These functions were then compared using goodness-of-fit indexes. Finally, two functions with similar goodness-of-fit values were chosen. The findings of this research project will complement the already available information and may be used in various research and implementation projects related to the development or improvement of currently used crystallised carbon dioxide conversion processes.
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Access control systems are part of the overall protection of objects. It is often the first system with which it is necessary to start the contact system; therefore, it is necessary to ensure its proper functioning. In the event of a malfunction, it
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Access control systems are part of the overall protection of objects. It is often the first system with which it is necessary to start the contact system; therefore, it is necessary to ensure its proper functioning. In the event of a malfunction, it can cause downtime in production, and it is triggered by a bad replacement of workers. Access control systems have their own specificities that need to be considered when designing security. Poor selection of access control devices can cause inefficient system functionality, resulting in downtime and loss. Based on experimental testing and related work in access control systems, this paper discusses the possibilities of testing the throughput of access control systems. The manuscript presents the design of a unique test device that can be used in the assessment of the reliability and throughput of access control systems. With the help of tests, we were able to determine the probability of downtime due to inappropriately set time intervals for changing employees on a work shift.
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This study was conducted to compare and analyze whether Pilates exercise and yoga exercise help improve the performance of female fencers and prevent injury, and the dynamic balance test (LQ-YBT) and functional movement screening (FMS) test score of the elite adult female fencers
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This study was conducted to compare and analyze whether Pilates exercise and yoga exercise help improve the performance of female fencers and prevent injury, and the dynamic balance test (LQ-YBT) and functional movement screening (FMS) test score of the elite adult female fencers were compared and analyzed as evaluation indicators. Participants were randomly classified into Pilates (n = 10) and yoga groups (n = 10), members of which took part in 50 min of exercise (5 min of warm-up, 40 min of main exercise, and 5 min of cool-down) twice weekly for eight weeks. The results obtained from this study were analyzed via independent t-test and 2-way ANOVA. The results were as follows: LQ-YBT measures (reaching distance) increased significantly for both groups, as did FMS scores (deep squat, hurdle step, inline lunge, shoulder mobility, active straight-leg raise, trunk-stability push-up, and rotary stability). These results suggest that Pilates exercise and yoga exercise might be likely effective in improving the performance of adult female fencers and injury prevention by increasing their dynamic balance ability and functional movement.
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This study examines the effect of the ethical climate on job satisfaction in the nursing profession and how this effect occurs through trust in colleagues. A survey design was used to collect data from 407 nurses working in hospitals in Mersin City, Turkey.
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This study examines the effect of the ethical climate on job satisfaction in the nursing profession and how this effect occurs through trust in colleagues. A survey design was used to collect data from 407 nurses working in hospitals in Mersin City, Turkey. The study used self-report questionnaires to measure the ethical climate, job satisfaction, and trust. The data were analyzed using SPSS 22 software, which incorporated confirmatory factor analysis to assess construct validity and the bootstrap method to examine mediation effects. Ethical protocols were rigorously observed. The study clearly demonstrated a significant positive relationship between the ethical climate and job satisfaction. The trust variable fully mediates the relationship between the ethical climate and job satisfaction. The findings make a strong case for the importance of an ethical climate in nursing, synthesizing findings from the previous literature. The findings of this study demonstrate the necessity of assessing different attitudes and behaviors in order to promote expected behaviors in the unique and intense working environment of nurses. These behaviors may diverge from theoretical predictions. The results of this study also revealed that an ethical climate and positive work attitudes among nurses have a significant effect on job satisfaction, which is an important input for productivity.
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Lavinia Balan, Anca Maria Cimpean, Prashant Sunil Nandarge, Bogdan Sorop, Catalin Balan, Madalina Alexandra Balica, Felix Bratosin, Simona Brasoveanu, Madalina Boruga and Laurentiu Pirtea
Biomedicines2024, 12(5), 1109; https://doi.org/10.3390/biomedicines12051109 (registering DOI) - 16 May 2024
This systematic review evaluates the clinical outcomes and molecular predictors of response to pembrolizumab in patients with advanced and metastatic cervical cancer. We adhered to the PRISMA guidelines for systematic reviews, conducting a database search in PubMed, Scopus, and Embase. The eligibility criteria
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This systematic review evaluates the clinical outcomes and molecular predictors of response to pembrolizumab in patients with advanced and metastatic cervical cancer. We adhered to the PRISMA guidelines for systematic reviews, conducting a database search in PubMed, Scopus, and Embase. The eligibility criteria centered on clinical outcomes, including the overall survival (OS), progression-free survival (PFS), and immune-related biomarkers post-pembrolizumab therapy. We included both prospective and retrospective studies that detailed clinical outcomes and molecular characteristics predictive of therapeutic response. Our search yielded six studies involving 846 patients treated with pembrolizumab from 2017 to 2022. The meta-analysis of these studies showed that pembrolizumab, used as monotherapy or in combination with chemotherapy, extended the OS by a weighted median of 10.35 months and the PFS by 8.50 months. The treatment demonstrated a pooled objective response rate (ORR) of 22.39%, although the I2 test result of 67.49% showed a high heterogeneity among the studies. Notably, patients with high PD-L1 expression (CPS ≥ 10) experienced improved outcomes in terms of the PFS and OS. The most common complications were fatigue, diarrhea, and immune-related adverse events. Pembrolizumab significantly enhances clinical outcomes in metastatic cervical cancer, particularly among patients with high PD-L1 expression. The drug maintains a good safety profile, reinforcing its treatment potential for patients with advanced and metastatic cervical cancer. Future studies should explore long-term effects and strategies to integrate pembrolizumab optimally into current treatment regimens, aiming to maximize patient benefits and effectively manage side effects.
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