Thermal barrier coatings (TBCs) are widely used to improve the oxidation resistance and high-temperature performance of nickel-based superalloys operating in aggressive environments. Among the TBCs, aluminide coatings (ACs) are commonly utilized to protect the structural parts of jet engines against high-temperature oxidation and corrosion. They can be deposited by different techniques, including pack cementation (PC), slurry aluminizing or chemical vapor deposition (CVD). Although the mentioned deposition techniques have been known for years, the constant developments in materials sciences and processing stimulates progress in terms of ACs. Therefore, this review paper aims to summarize recent advances in the AC field that have been reported between 2019 and 2023. The review focuses on recent advances involving improved corrosion resistance in salty environments as well as against high temperatures ranging between 1000 °C and 1200 °C under both continuous isothermal high-temperature exposure for up to 1000 h and cyclic oxidation resulting from AC application. Additionally, the beneficial effects of enhanced mechanical properties, including hardness, fatigue performance and wear, are discussed. Full article

The effects of rare earth Ce on the microstructure and properties of cast pure copper were investigated through thermodynamic calculations, XRD analysis, mechanical testing, metallographic microscopy, and scanning electron microscopy (SEM). The experimental results demonstrate that the reaction between rare earth Ce and oxygen as well as sulfur in copper exhibits a significantly negative Gibbs free energy value, indicating a strong thermodynamic driving force for deoxidation and desulfurization reactions. Ce is capable of removing trace amounts of O and S from copper. Moreover, the maximum solid solubility of Ce in Cu falls within the range of 0.009% to 0.01%. Furthermore, Ce can refine columnar grains while enlarging equiaxed grains in as-cast copper. Upon the addition of rare earth Ce, the tensile strength increased by 8.45%, elongation increased by 12.1%, and microhardness rose from 73.5 HV to 81.2 HV—an increase of 10.5%. Overall, rare earth Ce has been found to enhance both the microstructure and mechanical properties of cast pure copper. Full article

This paper presents the design and development of an electronic controller for accurate temperature management for the storage of biological and chemical samples in healthcare applications. In the introduction, some important application aspects related to the use of temperature control devices in healthcare are discussed. Keeping these aspects in mind, a brief overview of some related works is presented. The findings are then translated to specific requirements for an electronic controller, which is to be used in a temperature control device. These requirements made necessary the development of a custom controller, as no readily available solutions could be obtained. The paper proceeds with the design of a suitable architecture and discusses some of the design choices. Then, some implementation details are presented and the prototype controller, together with its user interface, is illustrated. Experiments are conducted and several points for improvement are identified. Overall, the main task of keeping accurate, traceable temperature at all times is accomplished successfully, and the electronic controller proves to be a viable solution that conforms to the identified requirements. Future versions will improve the speed of the temperature adaptation and include better user interface and wireless connectivity for remote monitoring and control. Full article

Solid–liquid two-phase flowmeters are widely used in critical sectors, such as petrochemicals, energy, manufacturing, the environment, and various other fields. They are indispensable devices for measuring flow. Currently, research has primarily focused on gas–liquid two-phase flow within the flowmeter, giving limited attention to the impact of solid phases. In practical applications, crude oil frequently contains solid particles and other impurities, leading to equipment deformation and a subsequent reduction in measuring accuracy. This paper investigates how particle dynamic parameters affect the erosion evolution characteristics of flowmeters operating in solid–liquid two-phase conditions, employing the dynamic boundary erosion prediction method. The results indicate that the erosion range and peak erosion position on the overcurrent wall of the solid–liquid two-phase flowmeter vary with different particle dynamic parameters. Erosion mainly occurs at the contraction section of the solid–liquid two-phase flowmeter. When the particle inflow velocity increases, the erosion range shows no significant change, but the peak erosion position shifts to the right, primarily due to the evolution of the erosion process. With an increase in particle diameter, the erosion range expands along the inlet direction due to turbulent diffusion, as particles with lower kinetic energy exhibit better followability. There is no significant change in the erosion range and peak erosion position with an increase in particle volume fraction and particle sphericity. With a particle inflow velocity of 8.4 m/s, the maximum erosion depth reaches 750 μm. In contrast, at a particle sphericity of 0.58, the minimum erosion depth is 251 μm. Furthermore, a particle volume fraction of 0.5 results in a maximum flow coefficient increase of 1.99 × 10⁻³. Full article

This paper proposes the design of virtual antenna arrays with frequency diversity for radar systems in fifth-generation flying ad hoc networks. These virtual arrays permit us to detect targets from the sky with flying drones. Each array element is composed of a microstrip antenna mounted on quadcopter drones and is virtually connected with the other elements. The antennas are tuned to work at the lower fifth-generation frequency band of 3.5 GHz. The design process considers the optimization of frequency offsets and positions for each element to obtain a side lobe level reduction. This methodology is carried out by particle swarm optimization. Several design examples are presented with random frequency offsets and non-uniform positions. These designs are compared to uniform-spaced arrays excited with Hamming frequency offsets. The simulation results show that using random frequency offsets and non-uniform positions provides a minor side lobe level reduction. This research demonstrates the feasibility of using virtual arrays for radar systems in fifth-generation flying ad hoc networks. Full article

Proton exchange membrane fuel cells (PEMFCs), as an important utilization of hydrogen energy, contribute to the sustainable development of global energy. Pulsed ejectors have a high potential for improving the hydrogen utilization of PEMFCs in the full operating range by circulating unconsumed hydrogen. In this study, a pulsed ejector applied to a 120 kW fuel cell was designed, and the flow characteristics were analysed using computational fluid dynamics (CFD). Based on the data from the CFD model, the global optimization of the ejector was carried out using the Gaussian process regression (GPR) surrogate model and the grey wolf optimization (GWO) algorithm. The local structure was then further optimized using an adjoint method coupling streamlining modification that takes into account the local flow characteristics. The CFD results showed that, under a fixed structure, increasing the pressure difference between the secondary flow and the ejector outlet would promote boundary layer separation, shorten the shockwave chain length, change the effective flow area of the secondary flow, and lower the entrainment ratio (ER). The analytical results from the GPR model indicated significant interactions among the structural parameters. The globally optimized ejector using GPR and GWO improved the hydrogen entrainment ratio from 1.42 to 3.12 at the design point. Furthermore, the results of streamlining local optimization show that the entrainment ratio increased by 1.67% at the design point and increased by up to 3.99% over the full operating range compared to the optimized ejector by global optimization. Full article

To solve the short working distance and small measurement range of an all-fibre interferometer, we proposed a Mach–Zehnder Fabry–Perot hybrid fibre-optic interferometry system based on sinusoidal phase modulation. In this paper, a low-finesse fibre interferometer with a larger linear operating range for displacement measurement is realised using a self-collimating probe and incorporating a Kalman filter-based phase demodulation algorithm. Through experimental comparisons, it is demonstrated that the interferometer proposed in this paper can effectively reduce the phase delay, compensate for the depth of modulation drift, and correct the error due to parasitic interference introduced by the optical path structure through the algorithm. A linear large measurement working range of 20 cm is realised. Full article

A general procedure to prepare gold nanourchins (GNUs) via a seed-mediated method was followed using dopamine hydrochloride as a reducing agent and silver nitrate salt (AgNO₃) as a shape-directing agent. The novelty of this study comes from the successful incorporation of the prepared gold urchins as an aqueous suspension in a nasal pressurized metered dose inhaler (pMDI) formulation and the investigation of their potential for olfactory targeting for direct nose-to-brain drug delivery (NTBDD). The developed pMDI formulation was composed of 0.025% w/w GNUs, 2% w/w Milli-Q water, and 2% w/w EtOH, with the balance of the formulation being HFA134a propellant. Particle integrity and aerosolization performance were examined using an aerosol exposure system, whereas the nasal deposition profile was tested in a sectioned anatomical replica of human nasal airways. The compatibility of the gold dispersion with the nasal epithelial cell line RPMI 2650 was also investigated in this study. Colloidal gold was found to be stable following six-month storage at 4 °C and during the lyophilization process utilizing a pectin matrix for complete re-dispersibility in water. The GNUs were intact and discrete following atomization via a pMDI, and 13% of the delivered particles were detected beyond the nasal valve, the narrowest region in the nasal cavity, out of which 5.6% was recovered from the olfactory region. Moreover, the formulation was found to be compatible with the human nasal epithelium cell line RPMI 2650 and excellent cell viability was observed. The formulated GNU-HFA-based pMDI is a promising approach for intranasal drug delivery, including deposition in the olfactory region, which could be employed for NTBDD applications. Full article

Random polypropylene is considered an alternative material to regular polypropylene for applications where improved impact and creep resistance, as well as stiffness, are required. Random polypropylene nanocomposites reinforced with dimethyldichlorosilane-treated silica particles were prepared using meltmixing. The effect of varying the nanoparticles’ content on the structural, mechanical, damping and thermal behavior of the nanocomposites was investigated. The results indicated the improved deformation potential, fracture toughness, and energy storage capacity of the matrix with increasing the filler content. It was observed that the use of high filler fractions limited the reinforcing efficiency of the SiO₂ nanoparticles due to the formation of large agglomerates. The nanoparticles’ segregation was initially advised by modeling Young’s modulus but was also confirmed by electron imaging. Examination of the thermal properties of the nanocomposites indicated the limited effect of the nanoparticles on the melting behavior along with the thermal stability of the matrix. These results confirmed the usage of silica nanoparticles as a way of further improving the mechanical and thermomechanical properties of random polypropylene. Full article

The paper presents a proposed methodology for designing and planning research on driver behavior at pedestrian crossings using whole-vehicle simulators. It was assumed that dedicated research should be conducted in specific problem contexts. The problems identified were the identification of hazards and the risk of accidents involving vulnerable road users. The purpose of this identification is to determine the determinants of safety at pedestrian crossings, which should constitute guidance when designing new solutions for safety support systems at pedestrian crossings. A number of hazard factors were identified; divided into categories, including types of crossings, location, and surroundings; behavior of vulnerable road users; and attention (focus) distractors, both inside and outside the vehicle. A method for defining and selecting research scenarios and selecting a group of research participants was proposed. Additionally, it was proposed to conduct repeatable test scenarios for different driving speeds and different weather conditions. With respect to the publications on this topic, this work focuses on the process of designing and planning dedicated simulation studies, which may provide a source of guidance and good practices for other researchers. This is an example of how interdisciplinary research involving human factors, traffic organization, and ITS systems can be planned and implemented. Full article

Sinonasal intestinal-type adenocarcinoma (ITAC) is a very rare, closely occupational-related tumor with strong histological similarities to colorectal cancer (CRC). In the latter, tumor budding (TB) is widely recognized as a negative prognostic parameter. The aim of this study was to evaluate the prognostic role of TB in ITAC and to correlate it with other established or emerging biomarkers of the disease, such as p53 and deficient DNA mismatch repair (MMR) system status/microsatellite instability (MSI). We retrospectively analyzed 32 consecutive specimens of patients with ITAC diagnosis treated in two institutions in Northern Italy. We reviewed surgical specimens for TB evaluation (low-intermediate/high); p53 expression and MMR proteins were evaluated via immunohistochemistry. Results were retrospectively stratified using clinical data and patients’ outcomes. According to bud counts, patients were stratified into two groups: intermediate/high budding (>4 TB) and low budding (≤4 TB). Patients with high TB (>4) have an increased risk of recurrence and death compared to those with low TB, with a median survival of 13 and 54 months, respectively. On multivariate analysis, considering TB, therapy, and stage as covariates, TB emerged as an independent prognostic factor net of the stage of disease or type of therapy received. No impact of p53 status as a biomarker of prognosis was observed and no alterations regarding MMR proteins were identified. The results of the present work provide further significant evidence on the prognostic role of TB in ITAC and underline the need for larger multicenter studies to implement the use of TB in clinical practice. Full article

Background: Surgical aortic valve replacement (SAVR) is often complicated by acute kidney injury (AKI). Identifying patients at risk of AKI is important to start nephroprotective strategies or renal replacement therapy (RRT). This study investigated the incidence and risk factors of post-operative AKI in SAVR patients. Chronic kidney disease (CKD) developed in the post-cardiac-surgery follow-up period was also assessed. Methods: A total of 462 SAVR patients were retrospectively enrolled. The primary endpoint was the occurrence rate of AKI after surgery. Kidney recovery, during two planned outpatient clinic nephrological visits within 12 months after the surgery, was assessed. Results: A total of 76 patients experienced an AKI event. A Kaplan–Meier analysis revealed that subjects with CKD stage IV had a time to progression of 2.7 days, compared to patients with stages I–II, who were characterized by the slowest progression time, >11.2 days. A Cox regression indicated that CKD stages predicted a higher risk of AKI independently of other variables. During their ICU stay, 23 patients died, representing 5% of the population, most of them requiring RRT during their ICU stay. A severe CKD before the surgery was closely related to perioperative mortality. During the follow-up period, 21 patients with AKI worsened their CKD stage. Conclusions: AKI represents a common complication for SAVR patients in the early post-operative period, prolonging their ICU stay, with negative effects on survival, especially if RRT was required. Pre-operative CKD >3 stage is an independent risk factor for AKI in patients undergoing SAVR. Full article

Two series of sugar esters with alkyl chain lengths varying from 5 to 12 carbon atoms, and with a head group consisting of glucose or galactose moieties, were synthesized. Equilibrium surface tension isotherms were measured, yielding critical micellar concentration (CMC) surface tensions at CMC (γcmc) and minimum areas at the air–water interface (Amin). In addition, Krafft temperatures (Tks) were measured to characterize the ability of molecules to dissolve in water, which is essential in numerous applications. As a comparison to widely used commercial sugar-based surfactants, those measurements were also carried out for four octyl d-glycosides. Impacts of the linkages between polar and lipophilic moieties, alkyl chain lengths, and the nature of the sugar head group on the measured properties were highlighted. Higher Tk and, thus, lower dissolution ability, were found for methyl 6-O-acyl-d-glucopyranosides. CMC and γcmc decreased with the alkyl chain lengths in both cases, but Amin did not appear to be influenced. Both γcmc and Amin appeared independent of the ester group orientation. Notably, alkyl (methyl α-d-glucopyranosid)uronates were found to result in noticeably lower CMC, possibly due to a closer distance between the carbonyl function and the head group. Full article

Coastal sediment grain size is an important factor in determining coastal morphodynamics. In this study, we explore a novel approach for retrieving the median sediment grain size (D50) of gravel-dominated beaches using Synthetic Aperture Radar (SAR) spaceborne imagery. We assessed this by using thirty-six Sentinel-1 (C-band SAR) satellite images acquired in May and June 2022 and 2023, and three NovaSAR (S-band SAR) satellite images acquired in May and June 2022, for three different training sites and one test site across England (the UK). The results from the Sentinel-1 C-band data show strong positive correlations (R²$\ge 0.75$) between the D50 and the backscatter coefficients for 15/18 of the resultant models. The models were subsequently used to derive predictions of D50 for the test site, with the models which exhibited the strongest correlations resulting in Mean Absolute Errors (MAEs) in the range 2.26–5.47 mm. No correlation (R² = 0.04) was found between the backscatter coefficients from the S-band NovaSAR data and D50. These results highlight the potential to derive near-real time estimates of coastal sediment grain size for gravel beaches to better inform coastal erosion and monitoring programs. Full article

We consider a toy model for the study of monitored dynamics in many-body quantum systems. We study the stochastic Schrödinger equation resulting from continuous monitoring with a rate $\Gamma$ of a random Hermitian operator, drawn from the Gaussian unitary ensemble (GUE) at every time t. Due to invariance by unitary transformations, the dynamics of the eigenvalues ${\left\{{\lambda }_{\alpha }\right\}}_{\alpha =1}^n$ of the density matrix decouples from that of the eigenvectors, and is exactly described by stochastic equations that we derive. We consider two regimes: in the presence of an extra dephasing term, which can be generated by imperfect quantum measurements, the density matrix has a stationary distribution, and we show that in the limit of large size $n\to \infty$ it matches with the inverse-Marchenko–Pastur distribution. In the case of perfect measurements, instead, purification eventually occurs and we focus on finite-time dynamics. In this case, remarkably, we find an exact solution for the joint probability distribution of $\lambda$’s at each time t and for each size n. Two relevant regimes emerge: at short times $t\Gamma =O\left(1\right)$, the spectrum is in a Coulomb gas regime, with a well-defined continuous spectral distribution in the $n\to \infty$ limit. In that case, all moments of the density matrix become self-averaging and it is possible to exactly characterize the entanglement spectrum. In the limit of large times $t\Gamma =O\left(n\right)$, one enters instead a regime in which the eigenvalues are exponentially separated $\log ({\lambda }_{\alpha }/{\lambda }_{\beta })=O(\Gamma t/n)$, but fluctuations $\sim O\left(\sqrt{\Gamma t/n}\right)$ play an essential role. We are still able to characterize the asymptotic behaviors of the entanglement entropy in this regime. Full article

Mediterranean areas will likely undergo climate shifts in the near future that modify the water resources for vegetation. However, in some regions of southwestern Spain, such as Extremadura, the impact of different future scenarios on the water resources for vegetation has not been studied extensively. This study focused on the quantification and spatial distribution of water resources for vegetation covers in Extremadura and analyzed the impact of future climate change scenarios on those water resources. For this, five downscaled global climate models from Coupled Model Intercomparison Project phase 6 (CMIP6) were used in four future periods (from 2021 to 2100) following two Shared Socioeconomic Pathways (SSP-2.45 and SSP-5.85). These projections were compared with a historical baseline period (1970–2000) to obtain the variation of water resources. The results showed decreases in the water resources for all the scenarios and periods analyzed compared to those observed in the historical baseline period. The smallest decreases were noted over 2041–2060 for SSP2-4.5, with almost 74% of the region decreasing between 15 and 18% (with an average of 16.4%). The greatest decreases were over 2081–2100 for SSP5-8.5, in which 90% of the region displayed water resource declines of greater than 50%. In this last situation, the three more widespread vegetation covers (agrosilvopastoral systems of dehesas, grasslands, and crops) underwent similar declines of around 55% of their water resources (from ≈203 to ≈93 mm), while the fourth widely spread vegetation cover, forests, declined by 49% (from ≈261 to ≈133 mm). If any of these future projections occur, the decline in water resources could modify the forest composition and structure of these water-dependent ecosystems, compromising their maintenance and ecological, cultural, and economic functions. Full article

Theological education in Africa is currently at a crossroads and requires a thorough re-evaluation. The framework for teaching and learning introduced by missionaries during colonial times, which often prioritized Western perspectives and ignored indigenous African contexts, does not adequately address the complex issues and needs of African communities today. As a result, the impact of theological practice lacks both relevance and sustainability within grassroots communities. There is therefore a need for a theological framework that is more relevant, contextual, and responsive to the realities and aspirations of African people in the present context. This article advocates for the decolonization of theological education for a praxical approach rooted in lived experiences. It is essential to firmly anchor theological reflection and action in African traditions in order to effectively address contextual issues. This calls for action beyond academic reform towards meeting the pressing needs of the population. This article sheds light on the inadequacies of the colonial framework within theological education, serving as crucial indicators for holistic and sustainable transformation within the field. Case studies drawn from theological institutions, and local churches from selected countries in East, Central and Southern Africa provide nuanced insights into the importance of this transformative process. Full article

Underwater vision technology is crucial for marine exploration, aquaculture, and environmental monitoring. However, the challenging underwater conditions, including light attenuation, color distortion, reduced contrast, and blurring, pose difficulties. Current deep learning models and traditional image enhancement techniques are limited in addressing these challenges, making it challenging to acquire high-quality underwater image signals. To overcome these limitations, this study proposes an approach called adaptive multi-scale multi-color space underwater image enhancement with GAN-physics fusion (AMSMC-UGAN). AMSMC-UGAN leverages multiple color spaces (RGB, HSV, and Lab) for feature extraction, compensating for RGB’s limitations in underwater environments and enhancing the use of image information. By integrating a membership degree function to guide deep learning based on physical models, the model’s performance is improved across different underwater scenes. In addition, the introduction of a multi-scale feature extraction module deepens the granularity of image information, learns the degradation distribution of different image information of the same image content more comprehensively, and provides useful guidance for more comprehensive data for image enhancement. AMSMC-UGAN achieved maximum scores of 26.04 dB, 0.87, and 3.2004 for PSNR, SSIM, and UIQM metrics, respectively, on real and synthetic underwater image datasets. Additionally, it obtained gains of at least 6.5%, 6%, and 1% for these metrics. Empirical evaluations on real and artificially distorted underwater image datasets demonstrate that AMSMC-GAN outperforms existing techniques, showcasing superior performance with enhanced quantitative metrics and strong generalization capabilities. Full article

Type 2 diabetes mellitus (T2DM) is a significant risk factor for stroke. Nevertheless, the evidence supporting stringent glycemic control to reduce macrovascular complications, particularly stroke, is not as clear as for microvascular complications. Presently, risk reduction strategies are based on controlling multiple risk factors, including hypertension, dyslipidemia, glycemia, smoking, and weight. Since 2008, new pharmacological therapies for treating T2DM have been required to undergo trials to ensure their cardiovascular safety. Remarkably, several novel therapies have exhibited protective effects against the combined endpoint of major cardiovascular events. Evidence from these trials, with stroke as a secondary endpoint, along with real-world data, suggests potential benefits in stroke prevention, particularly with glucagon-like peptide 1 receptor agonists. Conversely, the data on sodium–glucose cotransporter type 2 inhibitors remains more controversial. Dipeptidyl peptidase 4 inhibitors appear neutral in stroke prevention. More recent pharmacological therapies still lack significant data on this particular outcome. This article provides a comprehensive review of the evidence on the most recent T2DM therapies for stroke prevention and their impact on clinical practice. Full article

As a representative of the scientific and technological achievements of the new era, the overall development of virtual reality (VR) technology is becoming increasingly refined, which provides new development ideas and technical support in the field of ancient building restoration and architectural heritage preservation. In this context, digital conservation and the practice of architectural heritage have become important focuses of application in the industry. This paper starts from the core concept of VR technology, analyzes the value of the application of VR technology in the protection of ancient architecture, puts forward relevant suggestions and technical application methods, and takes Red Pagoda in Fuliang County as an example. In this sense, virtual reality technology is used to restore and protect the buildings, forming a digital heritage of ancient architecture. This study first utilizes a three-dimensional laser scanning instrument to collect point cloud data, and then the plane graph is drawn by measurement. Then, an Architectural Heritage Building Information Model is created, and comprehensive information on historical buildings is integrated. Finally, VR technology is used to show the effect of digital display and preservation. This study transforms architectural cultural heritage into a shareable and renewable digital form through restoration and reproduction, interpreting and utilizing it from a new perspective and providing new ideas and methods for architectural heritage conservation. Full article

This article builds on and supplements an earlier one in this journal about theodicy. It focuses on species extinctions and on the possible role of humanity as fallible co-creators. Christopher Southgate has suggested that co-creators might shoulder the task of curtailing extinctions. In appraising this view, I distinguish between extinctions resulting from evolution, which humans have limited power to reverse, but which are held to be indispensable for the evolution of complexity, consciousness and self-consciousness, and those caused by humanity itself, which humans should reduce, even if they cannot be halted. Human creativity, however, extends further to the development of skills, trades, the arts and literature. Church Fathers, such as Ambrose, Theodoret and Cosmas Indicopleustes, held that God left the creation incomplete so that humanity could enhance it; certainly, human creativity has introduced agriculture, navigation, technology and culture, adding to the value of the world. Granted belief in creation, this can be understood as co-creation. Granted the value that humanity continues to add to the world, the belief that such creativity flows from the creator’s overall plan emerges as a coherent one. Full article

The use of thin-ply composite materials has rapidly increased due to their tailorable mechanical properties and design flexibility. Considering an adhesively bonded composite joint, peel stress stands out as a key contributor leading to failure among other primary stress factors. Therefore, the reinforcement of carbon fiber-reinforced polymer (CFRP) laminates throughout the thickness could be considered as an approach to improve the joint strength. Using thin plies locally between the conventional CFRP layers in a laminate can enhance the strength, as the sudden change in stiffness means that the load transfer is not monotonous. Consequently, the following study examined the effect of altering thin plies gradually throughout the thickness on the behaviour of the CFRP laminates when subjected to transverse tensile loading. To achieve this goal, the CFRP laminates were gradually modified by using different commercially accessible prepreg thin plies, leading to an improved overall structural performance by reducing stress concentrations. Besides conducting an experimental study, a numerical assessment was also carried out utilizing Abaqus software with a Representative Volume Element (RVE) at the micro scale. The comparison of reference configurations, which involved various thin plies with different thicknesses and traditional CFRP laminates, with the suggested gradual configuration, demonstrated a notable enhancement in both strength and material cost. Furthermore, the proposed RVE model showed promising capability in accurately forecasting the strength of fabricated laminates. Full article