Peripheral artery disease (PAD) is a common circulatory disorder characterized by the accumulation of fats, cholesterol, and other substances in the arteries that restrict blood flow to the extremities, especially the legs. The ankle brachial index (ABI) is a highly reliable and valid non-invasive test for diagnosing PAD. However, the traditional method has limitations. These include the time required, the need for Doppler equipment, the training of clinical staff, and patient discomfort. PWV refers to the speed at which an arterial pressure wave propagates along the arteries, and this speed is conditioned by arterial elasticity and stiffness. To address these limitations, we have developed a system that uses electrocardiogram (ECG) and photoplethysmography (PPG) signals to calculate pulse wave velocity (PWV). We propose determining the ABI based on this calculation. Validation was performed on 22 diabetic patients, and the results demonstrate the accuracy of the system, maintaining a margin of ±0.1 compared with the traditional method. This confirms the correlation between PWV and ABI and positions this technique as a promising alternative to overcome some of the limitations of the conventional method. Full article

In human–computer interaction interfaces, icons serve as highly symbolic elements that convey information and significantly influence the performance of visual search and other tasks. Thus, the selection of appropriate colors plays a crucial role in the design of human–computer interfaces. This study aimed to investigate the effects of icon color combinations on human visual search task performance across various cognitive load conditions. The experiment was divided into two parts, involving a cognitive load test experiment and an icon search task, wherein the former required participants to select the target icon from 16 de-colored icons, and the latter involved selecting the target icon from 16 color combinations of 8 colors (background colors: black, red, blue, and purple; foreground colors: white, yellow, green, and turquoise). A total of 20 participants (11 females and 9 males, all aged between 18 and 24 years) were recruited for this experiment to perform both tasks sequentially. Through a comprehensive consideration of factors such as the NASA-TLX scale, retrieval time, etc., the experimental results revealed that cognitive load increased with time pressure, resulting in varying optimal color combinations for different cognitive load levels. Additionally, background colors did not affect task response time under different cognitive loads, whereas white foreground color was superior to turquoise foreground color in a medium cognitive load environment. Meanwhile, our results recommend prioritizing white-on-black as the preferred color combination, given that it demonstrated excellent cognitive performance in all three cognitive load environments. Conversely, white-on-blue is not recommended as a color combination for the design of high cognitive load environments. Concerning medium cognitive load environments, yellow-on-red or white-on-purple color combinations were preferred. Finally, in low cognitive load environments, white-on-purple is recommended as the primary color combination. Overall, this study provides a theoretical reference for the future design of interactive interface icons across various contexts. Full article

In order to improve the plugging performance of high-temperature and high-salt oil reservoir plugging agents, this paper utilizes a copolymer composed of acrylamide and 2-acrylamide-2-methylpropanesulfonic acid (AM/AMPS) as the polymer, polyethyleneimine as the cross-linking agent, and nylon fiber as the stabilizer to develop a high-temperature- and high-salt-resistant gel system. This study analyzed and evaluated the temperature resistance, salt resistance and blocking performance of the gel system. The evaluation results show that the gel-forming strength of this gel system can reach an H level, and it has good thermal stability at the high temperature of 130 °C. At the high salinity of 240,720 mg/L, the syneresis rate remains below 2.5%, and the gel-forming time is greater than 15 h; the higher the temperature, the shorter the gelling time. The results of our sand-filled pipe-plugging experiment show that the gel system can adapt to sand-filled pipes with different levels of permeability, and reaching a plugging rate of 94%. Full article

Exact biopsy planning and careful execution of needle injection is crucial to ensure successful procedure completion as initially intended while minimizing the risk of complications. This study introduces a solution aimed at helping the operator navigate to precisely position the needle in a previously planned trajectory utilizing a mixed reality headset. A markerless needle tracking method was developed by integrating deep learning and deterministic computer vision techniques. The system is based on superimposing imaging data onto the patient’s body in order to directly perceive the anatomy and determine a path from the selected injection site to the target location. Four types of tests were conducted to assess the system’s performance: measuring the accuracy of needle pose estimation, determining the distance between injection sites and designated targets, evaluating the efficiency of material collection, and comparing procedure time and number of punctures required with and without the system. These tests, involving both phantoms and physician participation in the latter two, demonstrated the accuracy and usability of the proposed solution. The results showcased a significant improvement, with a reduction in number of punctures needed to reach the target location. The test was successfully completed on the first attempt in 70% of cases, as opposed to only 20% without the system. Additionally, there was a 53% reduction in procedure time, validating the effectiveness of the system. Full article

As the population ages, the incidence of age-related neurodegenerative diseases is rapidly increasing, and novel approaches to mitigate this soaring prevalence are sorely needed. Recent studies have highlighted the importance of gut microbial homeostasis and its impact on brain functions, commonly referred to as the gut–brain axis, in maintaining overall health and wellbeing. Nonetheless, the mechanisms by which this system acts remains poorly defined. In this review, we will explore how (poly)phenols, a class of natural compounds found in many plant-based foods and beverages, can modulate the gut–brain axis, and thereby promote neural health. While evidence indicates a beneficial role of (poly)phenol consumption as part of a balanced diet, human studies are scarce and mechanistic insight is still lacking. In this regard, we make the case that dietary (poly)phenols should be further explored to establish their therapeutic efficacy on brain health through modulation of the gut–brain axis, with much greater emphasis on carefully designed human interventions. Full article

Livestock monitoring is a task traditionally carried out through direct observation by experienced caretakers. By analyzing its behavior, it is possible to predict to a certain degree events that require human action, such as calving. However, this continuous monitoring is in many cases not feasible. In this work, we propose, develop and evaluate the accuracy of intelligent algorithms that operate on data obtained by low-cost sensors to determine the state of the animal in the terms used by the caregivers (grazing, ruminating, walking, etc.). The best results have been obtained using aggregations and averages of the time series with support vector classifiers and tree-based ensembles, reaching accuracies of 57% for the general behavior problem (4 classes) and 85% for the standing behavior problem (2 classes). This is a preliminary step to the realization of event-specific predictions. Full article

Globally, education systems are faced with dual workforce crises: a shortage of teachers and a lack of affordable housing. Attracting and retaining teachers through improved renumeration, working conditions, and quality preparation have been central. However, initiatives to attract and retain teachers mean little if the workforce cannot find appropriate (quality and affordable) housing within commuting distance to their workplaces. The present study undertakes a scoping review of research on the intersection of housing and the school education workforce. Specifically, we examine the volume, variety, and characteristics of evidence through the question of ‘What empirical studies have been published on the relationship between housing and the school education workforce?’ Online databases were used to identify 23 studies published in 2000–2024 from Australia, China, England, Kenya, Malaysia, New Zealand, Tanzania, Uganda, the UK, and the USA. Publications drew on a range of methods and housing was rarely the focal unit of analysis. This study finds that beyond establishing unaffordability through salary and housing costs ratios, and the peripheral inclusion of housing issues in studies, there is insufficient published peer reviewed evidence available to purposefully inform and measure interventions. Greater interdisciplinarity is required in research to highlight the complexity of issues at the intersection of housing (availability, affordability, and distance from workplaces) and workforce distribution. More rigorous data should be collected to support robust reporting on the state of housing for the school education workforce to deliver the type of evidence necessary to develop targeted and tailored interventions to improve outcomes for the workforce and ultimately students. Full article

The objective of this study was to investigate the feasibility of the mixture of tremella polysaccharide (TP) and citrus pectin (CP) as an emulsifier by evaluating its emulsifying ability/stability. The results showed that the TP:CP ratio of 5:5 (w/w) could effectively act as an emulsifier. CP, owing its lower molecular weight and highly methyl esterification, facilitated the emulsification of oil droplets, thereby promoting the dispersion of droplets. Meanwhile, the presence of TP enhanced the viscosity of emulsion system and increased the electrostatic interactions and steric hindrance, therefore hindering the migration of emulsion droplets, reducing emulsion droplets coalesce, and enhancing emulsion stability. The emulsification and stabilization performances were influenced by the molecular weight, esterified carboxyl groups content, and electric charge of TP and CP, and the potential mechanism involved their impact on the buoyant force of droplet size, viscosity, and steric hindrance of emulsion system. The emulsions stabilized by TP-CP exhibited robust environmental tolerance, but demonstrated sensitivity to Ca²⁺. Conclusively, the study demonstrated the potential application of the mixture of TP and CP as a natural polysaccharide emulsifier. Full article

Insulin-like peptide 3 (INSL3) is a biomarker for Leydig cells in the testes of vertebrates, and it is principally involved in spermatogenesis through specific binding with the RXFP2 receptor. This study reports the insl3 gene transcript and the Insl3 prepropeptide expression in both non-reproductive and reproductive tissues of Danio rerio. An immunohistochemistry analysis shows that the hormone is present at a low level in the Leydig cells and germ cells at all stages of Danio rerio testis differentiation. Considering that the insl3 gene is transcribed in Leydig cells, our results highlight an autocrine and paracrine function of this hormone in the Danio rerio testis, adding new information on the Insl3 mode of action in reproduction. We also show that Insl3 and Rxfp2 belonging to Danio rerio and other vertebrate species share most of the amino acid residues involved in the ligand–receptor interaction and activation, suggesting a conserved mechanism of action during vertebrate evolution. Full article

Long-baseline neutrino experiments represent the optimal platforms for probing the lepton Yukawa sector of the Standard Model, and significant experiments are either under construction or in the planning stages. This review delves into the scientific motivations behind these facilities, which stem from the pivotal 2012 discovery of the ${\theta }_{13}$ mixing angle. We provide an overview of the two ongoing projects, DUNE and HyperKamiokande, detailing their physics potential and the technical hurdles they face. Furthermore, we briefly examine proposals for forthcoming endeavors and innovative concepts that could push beyond conventional Superbeam technology. Full article

Frontline doctors’ clinical leadership (CL) is key to addressing healthcare sustainability challenges. Research shows CL requires professional learning. Significant investments into CL development notwithstanding, little evidence exists of how frontline clinicians learn leadership, highlighting an educational sustainability challenge. We propose a fundamental constitutive step towards understanding CL professional development (PD) through theorising and analysing CL-learning mechanisms and their association with clinicians’ leadership competences required for sustainable healthcare development. This mixed-methods study developed a concept of leadership learning patterns to assess doctors’ learning processes associated with sustained innovation. It analysed a post-course dataset of past participants of a CL-PD course (N = 150) and a pre-post dataset of an online CL-PD (N = 34). EFA demonstrated a reasonable factor model for the Leadership Learning Inventory, measuring two dimensions of doctors’ leadership learning patterns: Meaning-oriented and Problematic learning. Qualitative and quantitative analyses showed that Meaning-oriented learning increased significantly during CL-PD and is linked with sustainable leadership competences. This study suggests that the concept of leadership learning patterns is useful for evaluating the quality of clinical leadership learning processes during PD. It offers a conceptually and empirically sound way to assess clinical leadership learning involved in sustainable healthcare improvement, and the sustainability of educational interventions to support it. Full article

The consumption of fish in food may contain mercury, a harmful element and dangerous chemical detrimental to human health. The purpose of this study was to determine the mercury level in the hair of pregnant women with different fish intakes in their diets. The concentration of total mercury in hair was determined using an atomic absorption spectrometer. In this study, 98 pregnant women were invited to participate (aged from 18 to 48 years). The mean content of mercury in the hair of pregnant women in Northwestern Russia was 0.428 mg/kg (ranging from 0.018 to 3.1 mg/kg). As a result, 22% of women had mercury values above 0.58 mg/kg, which is considered dangerous for the fetus. The hair mercury concentration in a village area was higher than that in a city area (i.e., 0.548 mg/kg and 0.326 mg/kg). Moreover, the maximum level of mercury was noted for a group of pregnant women who consumed more than 5 kg/month of fish and fish products. Furthermore, the consumption of freshwater fish in the diet leads to a higher mercury content in the hair of pregnant women than the consumption of marine fish. Full article

Calmodulin (Calm), a crucial Ca²⁺ sensor, plays an important role in calcium-dependent signal transduction cascades. However, the expression and the relevance of Calm in stress and immune response have not been characterized in Megalobrama amblycephala. In this study, we identified the full-length cDNA of Calm (termed MaCalm) in blunt snout bream M. amblycephala, and analyzed MaCalm expression patterns in response to cadmium and Aeromonas hydrophila challenges. MaCalm was 1603 bp long, including a 5′-terminal untranslated region (UTR) of 97 bp, a 3′-terminal UTR of 1056 bp and an open reading frame (ORF) of 450 bp encoding a polypeptide of 149 amino acids with a calculated molecular weight (MW) of 16.84 kDa and an isoelectric point (pI) of 4.09. Usually, MaCalm contains four conservative EF hand motifs. The phylogenetic tree analysis indicated that the nucleotide sequence of MaCalm specifically clustered with Ctenopharyngodon idella with high identity (98.33%). Tissue distribution analysis demonstrated that the ubiquitous expression of MaCalm mRNA was found in all tested tissues, with the highest expression in the brain and the lowest expression in muscle. MaCalm showed significant upregulation at 14 d and 28 d post exposure to varying concentrations of cadmium in the liver; HSP70 transcripts in the liver significantly upregulated at 14 d post exposure to different concentrations of cadmium. Moreover, in response to the A. hydrophila challenge in vivo, MaCalm transcripts in the liver first increased and then decreased, but MaCalm transcripts in the kidney declined gradually with prolonged infection. After the A. hydrophila challenge, the expression level of HSP70 was significantly downregulated at 24 h in the liver and its expression level was notably downregulated at 12 h and at 24 h in the kidney. Collectively, our results suggest that MaCalm possesses vital roles in stress and immune response in M. amblycephala. Full article

Half-grouted sleeve connectors are a primary method for connecting rebar in prefabricated concrete structures. However, due to limitations in the construction environment, all kinds of grouting defects are inevitable, especially grouting voids. Additionally, fire disasters, among the most common types of disasters, significantly threaten the structural performance and safety of these prefabricated structures. Therefore, it is imperative to determine the mechanical properties of half-grouted sleeve connectors with grouting voids after high temperatures. This study designed and prepared 48 groups of half-grouted sleeve specimens with different grouting voids and defect locations. These specimens were heated to the specified temperature (25 °C, 200 °C, 300 °C, 400 °C, 500 °C, 600 °C), followed by unidirectional tensile testing after natural cooling. The experimental results showed that rebar fracture failure and rebar pulled-out failure were the failure modes of specimens. With the increase in temperature, bearing capacity, safety factor and ductility coefficient of specimens all decreased. When the temperature was lower than 400 °C, the specimen with void length less than twice the diameter of the rebar (i.e., 2d) had sufficient connection performance. For specimens with the same total void lengths, the bearing capacity of discrete voids is lower than concentrate voids at the same temperature. The load-displacement curve, safety coefficient, ductility coefficient and grey correlation degree of half-grouted sleeve specimens with grouting voids at different temperatures are analyzed and discussed, and the bond stress slip constitutive model is given. Grouting defects have greater influence on specimens after grey correlation analysis. Findings from this study provide valuable references for the safety performance evaluation of prefabricated structures with half-grouted sleeve connectors after exposure to fire. Full article

Based on the driving force-pressure-state-impact-response (DPSIR) model, 19 indicators were selected to construct a comparison between Zhuhai and Macao, two adjacent cities at the estuary of the Pearl River in China, which have different development models and water resource sustainable development strategies. Factors that may affect the sustainability of water resources were screened and placed according to the relationships of the five subsystems in the DPSIR model, establishing a sustainable evaluation model for water resources in the two cities. The results analyzed by Principal Component Analysis and Entropy methods showed that (1) Zhuhai City was greatly affected by the driving force, while Macao was greatly affected by the state system from 2012 to 2021. (2) From the trend changes, it can be seen that, in recent years, the water resources of the two cities have been moving towards sustainable development, and the management and protection of water resources have achieved remarkable results. From the evaluation results, it can be seen that implementing urban water-saving activities, strengthening the proportion of environmental water conservancy, public measures in public investment, upgrading sewage treatment machinery to improve sewage treatment rates, and other measures can effectively improve the current situation of water resources in both regions. In the future, the Zhuhai and Macao cities may continue to face a series of water resource pressures brought on by socio-economic developments. Therefore, an active adjustment of the development of the measurement of controlling wastewater discharge and saving water resources was proposed, adhering to the direction of sustainable development, and ensuring the benign development of socio-economic conditions and the ecological environment. This study can provide data to support regional water resource security and policy formulation with different political systems. Full article

Although scales that evaluate postpartum stress exist, they lack specificity in maternal postpartum stress. The MPSS was created because there was a need to assess maternal stress during the postpartum stage. The introduction of the MPSS has enriched the evaluation tools for postpartum stress and has helped understand maternal stress at various postpartum time points and identify women at high risk for postpartum stress during this period. The aim was to translate the MPSS into Spanish and study its psychometric properties. Postpartum women (N = 167) with a mean age of 34.26 (SD = 4.71) were involved in this study. In addition to the MPSS, a battery of instruments was administered: a demographic sheet, the Birth Satisfaction Scale (BSS) and the Edinburgh Postnatal Depression Scale (EPDS). The MPSS data were analyzed, checking item communality first. As a result, three items showed unsatisfactory communality values (h² < 0.40). Confirmatory Factor Analysis was conducted, comparing factor models using the full pool of MPSS items or the version without items with unacceptable communality. As a result, the original three-factor structure was endorsed on the Spanish MPSS, with better fit indices when removing items with low communality (RMSEA = 0.067, CFI = 0.99, TLI = 0.99). The reliability of this version was satisfactory (ω = 0.93). Finally, group comparisons for some perinatal variables were performed, showing no significant differences between groups of interest (p = 0.05 and above). To conclude, the MPSS will contribute to the existing literature, having a wider capacity to assess perinatal mental health difficulties in Spanish-speaking populations. Full article

In this article, the authors will describe a creative writing therapeutic group program they developed based on narrative therapy and narrative medicine principles. This was a Social Science and Humanities Research Council—Partnership Engagement Grant funded project, the aim of which was to develop a facilitator’s manual for people interested in offering this group, titled “Journey through Words”. The link to the agency partner’s website, where the manual is available, is provided. The group program is structured over 6 weeks and includes a writing prompt each week, focusing on the storyline of resilience rather than the storyline of diagnosis or disease. Using a narrative inquiry approach, the facilitators kept brief field notes following group meetings. These field notes indicate that although spirituality was not planned as an identified focus of the program, due to the space narrative therapy provides for people to describe their values, preferences, and hopes during hardship, the experience of the group was that members shared reflections which were deeply spiritual in nature. Full article

As cities strive to become sustainable, it is imperative to consider even the smallest components of the urban environment and prioritize sustainability. Ensuring the sustainability of urban furniture, especially the numerous benches found in cities, is crucial. This study proposes an alternative solution to the sustainability issue in cities regarding urban furniture. This is because a review of the literature indicates that while efforts have been made to evaluate the sustainability of urban amenities and furniture, studies conducting life cycle analysis specifically for urban furniture are lacking. This study will contribute to the identified gap in the literature by analyzing 14 different seating elements in recreational areas located in the city of Rize, Turkey, using the Ccalc program to calculate their carbon footprints. In the subsequent phase of this study, an eco-design process will be conducted based on the findings, aiming to create an eco-seating unit design. Based on the data obtained, materials with high environmental impact were identified, material replacement recommendations were made, and consequently, a model proposal was presented. The potential reduction in carbon footprints with the use of transformed materials was discussed. The findings revealed that carbon footprint values were particularly high in the seating units where concrete and polypropylene materials were used. Additionally, it was determined that solvent paint, especially varnish, affects the carbon footprint, and it was recommended that would be used in its natural form, which is eco-friendly. In conclusion, the recommendations developed for the sustainability of urban furniture in coastal areas will contribute to the future of cities and humanity. Full article

This study evaluated territorial disparities in dental care for disabled persons in Brazil’s public healthcare system from 2014 to 2023. The person-year incidence of outpatient dental procedures carried out by special care dentistry specialists and hospitalizations for dental procedures for disabled persons were compared across different regions and against the national estimate. In addition, productivity was correlated with oral health-related indicators. The significance level was set at 5%. The northern region exhibited the highest outpatient productivity, while the southern region showed lower productivity compared to the national estimate (both p-value < 0.05). This pattern was reversed in inpatient productivity (both p-value < 0.05), with the northeastern and central–western regions also below average (both p-value < 0.05). There were no significant correlations between the indicators and inpatient productivity, but outpatient productivity was positively correlated with the proportions of inhabitants who self-rated their general and oral health as “poor” or “very poor”, who have never visited a dentist, and who visited a dentist for tooth extraction (all p-values < 0.05). Territorial disparities in dental care for disabled persons were observed within Brazil’s public healthcare system, and they were correlated with unfavorable oral health-related indicators at the population level. Full article

Diarrhoea is a serious cause of mortality worldwide that can lead to dehydration, gut barrier function impairment, nutrient malabsorption, and alterations of the gut microbiota (dysbiosis). The current solutions for its management, such as oral rehydration salts (ORS), inhibitors of gut motility, antibiotics, and living probiotics, only partially counteract the mechanisms of the disease and do not provide a full coverage of the problem. The potential risks of the use of living probiotic strains, particularly in immunocompromised patients, can be eliminated with the use of tyndallized (heat-killed) postbiotic bacteria and yeast. ABB C22^® is a postbiotic combination of three tyndallized yeasts, namely Saccharomyces boulardii, Saccharomyces cerevisiae, and Kluyveromyces marxianus. To assess the action of the postbiotic combination on diarrhoea, immune and gut epithelial cell signalling assays, the gut barrier formation assay, and the rotavirus gene expression assay were performed. ABB C22^® showed a strong anti-inflammatory effect, an induction of the build-up of the gut epithelium, and a degree of protection against rotavirus infection. These experimental studies support the use of the postbiotic ABB C22^® as a solution for the management of diarrhoea and gastrointestinal conditions, alone or in combination with existing but incomplete treatments. Full article

Phenacoccus solenopsis Tinsley (Hemiptera: Coccomorpha: Pseudococcidae), the cotton mealybug, is an invasive polyphagous species that has been extending its geographic range, posing a conspicuous threat to many Mediterranean crops of economic importance. These include three species of Solanaceae, namely Solanum lycopersicum L. (tomato), Solanum tuberosum L. (potato) and Solanum melongena L. (eggplant) all of which are economically important worldwide. In this study, we used age-stage two-sex life tables to investigate the suitability of these three plant species as hosts for P. solenopsis and to calculate pestfitness, life history parameters and population projection parameters. All tested host plants that were suitable for the pest and eggplant host plant induced a higher fecundity (276.50 ± 10.78 eggs/female), net reproductive rate (R₀) (243.32 ± 15.83 offspring/female) and finite rate of increase (λ) (1.18 ± 0.0043 day⁻¹) and more extended adult longevity (males: 6.50 ± 0.34 day and females: 24.15 ± 0.50 days). Population growth predictions over a period of 90 days of infestation, commencing with an initial population of 10 eggs showed that adult population size was 674,551 on tomato, 826,717 on potato and 355,139 on eggplant. Our data on plant host preference of P. solenopsis will aid the development of appropriate management strategies and achieve successful control of this invasive pest in key Mediterranean crop systems. Full article

Dynamic microsimulations are tools to stochastically project (synthetic) microdata into the future. In spatial microsimulations, regional discrepancies are of particular interest and must be considered accordingly. In practice, the probabilities for state changes are unknown and must be estimated, usually from survey data. However, estimating such models on the regional level is often not feasible due to limited sample size and lack of geographic information. Simply applying the model estimated at the national level to all geographies leads to biased state transitions due to regional differences in level and distribution. In this paper, we introduce a model-based alignment method to adapt predicted probabilities obtained from a nationally estimated model to subregions by integrating known marginal distributions to re-introduce regional heterogeneity and create more realistic trajectories, particularly in small areas. We show that the model-adjusted transition probabilities can capture region-specific patterns and lead to improved projections. Our findings are useful to researchers who want to harmonise model outputs with external information, in particular for the field of microsimulation. Full article