Sézary syndrome (SS) is a rare primary cutaneous T-cell lymphoma variant. Despite various treatment options, it remains incurable, with a poor prognosis. There is an urgent need for additional descriptive research to enhance our understanding and treatment of SS. The aim of this retrospective register-based study was to outline patients’ demographic characteristics; investigate the clinical, histopathological, and molecular findings; and assess treatment effectiveness with a focus on time to next treatment (TTNT) and disease progression. Data on 17 patients with SS were obtained from the primary cutaneous lymphoma register in West Sweden between 2012 and 2024. The results revealed that not all patients exhibited the classical triad of symptoms at diagnosis, emphasizing the need for personalized diagnostic approaches. The median survival was only 2.1 years, which reflects the aggressive nature of SS. The longest median TTNT was observed in triple therapy involving retinoids, interferon alpha, and extracorporeal photopheresis (ECP). There was no significant difference in TTNT between various lines of treatment. Early initiation of ECP treatment did not result in improved outcomes. This study highlights the importance of combination therapy for improved outcomes and underscores the need for future studies to identify optimal treatment approaches. Full article

‘Ruixue’ apples were used as the test material to study the effect of 10 μM methyl jasmonate (MeJA) on the quality and cell wall metabolism of apples after 18 d of storage. The results showed that MeJA significantly decreased the respiratory rate, reduced the titratable acid content and maintained a high soluble solids content. MeJA has been shown to suppress the activities and gene expressions of WSP, CSP, ISP, and cellulose in contrast to the control group, thereby maintaining a lower cell permeability and higher exocarp firmness. MeJA significantly decreased the expression of MdACS, MdACO, MdPL, Mdgal, and MdPG genes in the apple exocarp when compared to the control group. In addition, the overexpression of MdPL18 increased the content of cell wall polysaccharides such as WSP and CSP, enhanced cell wall-degrading enzyme activities, and accelerated fruit ripening and softening, whereas silencing MdPL18 did the opposite. Together, these results demonstrate that exogenous MeJA maintains the Ruixue apple fruit quality by regulating the metabolism of cell wall substances. Full article

Jordan faces significant, immediate challenges of enhancing energy security while mitigating greenhouse gas emissions. One of the most promising approaches to achieve sustainable development, energy security, and environmental conservation is to increase the integration of renewable energy into electricity generation. To this end, the Jordanian government aims to expand investments in the green energy sector, with solar and wind energy expected to play a crucial role in meeting energy demands and promoting environmental sustainability. This paper aims to examine the distinct dynamics, challenges, obstacles, and potential solutions related to establishing community solar and wind farms in suburban areas of Jordan. It seeks to highlight the opportunities and barriers influencing the adoption of sustainable energy in the country. Evaluation results from engaging 320 key stakeholders were obtained through a questionnaire, and after comprehensive analysis, it became evident that the benefits and positive aspects of solar and wind farms outweigh their drawbacks and obstacles. These insights can be useful in guiding policies and practices to make renewable energy community projects a reality within Jordan’s suburban areas. Additionally, the findings may serve as a valuable benchmark for other regions facing similar challenges in their pursuit of a sustainable energy future. Full article

Fluorescent gold nanoclusters (AuNCs) have shown promise as metal ion sensors. Further research into surface ligands is crucial for developing sensors that are both selective and sensitive. Here, we designed simple tripeptides to form fluorescent AuNCs, capitalizing on tyrosine’s reduction capability under alkaline conditions. We investigated tyrosine’s role in both forming AuNCs and sensing metal ions. Two tripeptides, tyrosine–cysteine–tyrosine (YCY) and serine–cysteine–tyrosine (SCY), were used to form AuNCs. YCY peptides produced AuNCs with blue and red fluorescence, while SCY peptides produced blue-emitting AuNCs. The blue fluorescence of YCY- and SCY-AuNCs was selectively quenched by Fe³⁺ and Cu²⁺, whereas red-emitting YCY-AuNC fluorescence remained stable with 13 different metal ions. The number of tyrosine residues influenced the sensor response. DLS measurements revealed different aggregation propensities in the presence of various metal ions, indicating that chelation between the peptide and target ions led to aggregation and fluorescence quenching. Highlighting the innovation of our approach, our study demonstrates the feasibility of the rational design of peptides for the formation of fluorescent AuNCs that serve as highly selective and sensitive surface ligands for metal ion sensing. This method marks an advancement over existing methods due to its dual capability in both synthesizing gold nanoclusters and detecting analytes, specifically Fe³⁺ and Cu²⁺. Full article

Introduction: Descending necrotizing mediastinitis is one of the most lethal forms of acute mediastinitis. It originates from an odontogenic or deep neck infection, which descends to the mediastinum through the fascial planes. It is a rare condition, but mortality rates remain high, especially in the presence of comorbidities or predisposing factors. Delay in diagnosis has been shown to be one of the most important factors for the disease outcome. Therefore, early diagnosis and treatment by a multidisciplinary team are of utmost importance. Case series: Four healthy young males with descending necrotizing mediastinitis were treated at our institution. None of them had any comorbidities, but all of them waited between 3 and 4 days before seeking medical help. Upon their arrival at the hospital, in addition to the presence of a severe neck infection, the presence of mediastinitis was also found. Despite the timely surgical treatment of both the source of the infection and the mediastinitis, three of the four cases had a fatal outcome. Conclusion: We believe that the time factor is of greater importance for the outcome of acute descending mediastinitis than the factors of age and presence of accompanying diseases. Proper and rapid treatment by a multidisciplinary team is essential, even for young and healthy people. Full article

The parameters of the roll characteristics of a large-scale round bale machine were collected in real time to investigate the bale rolling mechanism. This investigation develops a set of adaptable and highly integrated data acquisition systems for the bale rolling performance parameters of large-type round bale machines. A rolling experiment is conducted using sunflower straw as the material, and the power consumption and radial tension of the roller-round bale machine during the bale rolling process are studied. In the grass core formation stage, the round bale machine’s torque need was minimal, the radial tension of the bale remained nearly constant, and the bale chamber was primarily filled with loose sunflower straw. The motor torque and the straw bale’s radial tension both showed a tendency of gradual increase when the round bale machine was in the grass-filling stage. The motor torque and bale radial tension displayed a roughly linear trend of rapid rise as the sunflower straw continued to enter the rolling bale chamber; this was when the round bale machine was in the compressed bale rolling stage. When the power consumption of the round bale machine was measured using the data acquisition system during the test bench empty run and core-creation stage, the energy consumption comparison analysis produced a relative error of 5.8%. During the stage of bale rolling and compression, the data acquisition system monitored the power consumption of the round bale machine. The relative error was 9.5%. The data acquisition system of the round bale machine test bed has an accuracy of 90.5%–94.2% when measuring the machine’s power consumption, indicating that it is a stable and efficient system. This study provides a foundation for further research on intelligent the roller-round bale machine. Full article

Chronic school absenteeism is a common problem in childhood and adolescence, and it is frequently observed in patients with somatic symptom and related disorders (SSRDs). This study aimed to determine whether and to what extent the presence of school absenteeism may be a risk factor for the diagnosis of SSRDs in hospitalised patients. This matched cohort study included children and adolescents aged between 8 and 17 years, admitted to the paediatric ward of the IRCCS Burlo Garofolo in Trieste from 2021 to 2023, who were divided into two groups, the first including children with at least 15 days of absence from school for medical reasons and the second including children with regular school attendance, matched to the former group by age and sex. We consecutively enrolled 70 patients, 35 in the absentee group and 35 in the control group. In the absentee group, 30/35 (85.7%) patients were diagnosed with an SSRD, while in the control group, 1/35 (2.9%) was diagnosed with an SSRD. The absentee group had a 30-fold higher risk of being diagnosed with SSRDs than the control group (RR = 30 [95% CI = 4.3–208]; p < 0.001). This study shows that in hospitalised children, a history of school absenteeism of more than two weeks is an important risk factor for the diagnosis of SSRDs. Full article

Gastrointestinal tract perforation is uncommon in children, accounting for <10% of cases of blunt abdominal trauma. Diagnosis of bowel perforation in children can be challenging due to poor diagnostic imaging accuracy. Intra-abdominal free air is found only in half of the children with bowel perforation. Ultrasound findings are nonspecific and suspicious for perforation in only two-thirds of cases. A computer tomography (CT) scan has a sensitivity and specificity of 50% and 95%, respectively. Surgical decisions should be made based on clinical examination despite normal CT results. Management of bowel perforation in children includes primary repair in 50–70% and resection with anastomosis in 20–40% of cases. Full article

This article explores transgenerational return migration to Galicia, Spain, focusing on participants of the Scholarships for Outstanding Youth Abroad (BEME) programme. It examines how descendants of Galician emigrants, primarily grandchildren and great-grandchildren of Galician emigrants to Latin America, engage with the Spanish and Galician languages. Drawing on semi-structured interviews with 30 participants, the article explores participants’ language ideologies regarding Galician as a minoritised language and Spanish as a global language. This article highlights the role of language as a symbolic resource in transgenerational return migration, offering a sociolinguistic perspective to the understanding of this migration phenomenon. Full article

For decades, linguists have been working to formulate an objective means of distinguishing dialects from languages, but dialect recognition has largely remained a subjective enterprise. Only recently have some studies proposed a processing-based psycholinguistic approach toward dialect recognition. These studies argued that dialect words are stored as a co-dependent representation, not as an independent representation of the words of bilingual speakers. Based on these studies, we investigated the lexical selection and processing mechanisms of bilingual and bidialectal speakers of two understudied languages, Oromo and Amharic, using the picture–word interference paradigm. We found independent lexical representations for both the bilingual and the bidialectal groups, which implies the involvement of the same cognitive mechanisms in both language and dialect processing. Thus, we argue that bidialectal speakers have flexible lexical representation and selection mechanisms that are dependent on the speakers’ previous language experience. Here, we propose a dynamic lexical selection model that accommodates diverse dialect ecologies. Full article

Sophora alopecuroides L., a perennial herb in the arid and semi-arid regions of northwest China, has the ecological functions of windbreaking and sand fixation and high medicinal value. In recent years, global warming and human activities have led to changes in suitable habitats for S. alopecuroides, which may affect the accumulation of natural products. In this study, MaxEnt 3.4 and ArcGIS 10.4 software were used to predict the distribution of potentially suitable habitats for S. alopecuroides in China under climate change. Furthermore, the geographical distribution of S. alopecuroides as affected by human activities, the differences in the content of natural products of S. alopecuroides between different suitable habitats, and the correlation between natural products and environmental factors were analyzed. The results showed that suitable habitats for S. alopecuroides were projected to expand in the future, and the major environmental factors were temperature (Bio1), rainfall (Bio18), and soil pH (pH). When Bio1, Bio18, and pH were 8.4283 °C, 7.1968 mm, and 9.9331, respectively, the distribution probability (P) of S. alopecuroides was the highest. After adding a human activity factor, the accuracy of the model prediction results was improved, and the area of suitable habitats was greatly reduced, showing a fragmented pattern. Meanwhile, habitat suitability had a specific effect on the content of natural products in S. alopecuroides. Specifically, the content of natural products in S. alopecuroides in wild habitats was higher than that in artificial cultivation, and highly suitable habitats showed higher contents than those in non-highly suitable habitats. The contents of total alkaloids and total flavonoids were positively correlated with human activities and negatively correlated with land use types. Among them, total alkaloids were negatively correlated with aspect, and total flavonoids were positively correlated with aspect. In addition, it is suggested that Xinjiang should be the priority planting area for S. alopecuroides in China, and priority should be given to protection measures in the Alashan area. Overall, this study provides an important foundation for the determination of priority planting areas and resource protection for S. alopecuroides. Full article

The nutritional composition of bovine liver, particularly in terms of vitamins E, β-carotene, and cholesterol concentration, is significantly influenced by the cattle-rearing system and diet. This study aimed to elucidate the impact of four predominant cattle-rearing systems in the Eastern Amazon region on the vitamin E, β-carotene content, and cholesterol levels in bovine liver during the rainy season. Liver-tissue samples were collected from 48 cattle, with twelve specimens representing each rearing system. The systems encompassed two native pastures located in flood-prone areas, cultivated pastures on upland terrain and a confinement-rearing system. Our findings indicate that, when considering all rearing systems collectively, there were no significant differences in the levels of vitamins and cholesterol in the liver tissues (p > 0.05). However, a marked disparity in cholesterol levels emerged when comparing intensive rearing systems to extensive ones, with the former demonstrating notably higher concentrations (p = 0.01). Additionally, the intensive rearing system was associated with elevated levels of β-carotene (p < 0.01), α-tocopherol (p = 0.01), and β-tocopherol (p = 0.01) relative to the extensive systems. No significant variations were observed amongst the different extensive systems (p > 0.05). These results suggest that, while all rearing systems yielded liver tissues with typical concentrations of vitamins and cholesterol, the intensive rearing system led to a higher accumulation of certain vitamin compounds. This study highlights the substantial nutritional implications of different cattle-rearing systems in the Eastern Amazon and provides valuable insights for developing dietary strategies to optimize the nutritional quality of bovine liver. Therefore, the generated results are groundbreaking in the Eastern Amazon, Brazil, and inspire the development of new research projects to address other demands in this field and achieve additional outcomes. Full article

Crowdsourced spatial analytics is a rapidly developing field that involves collecting and analyzing geographical data, utilizing the collective power of human observation. This paper explores the field of spatial data analytics and crowdsourcing and how recently developed tools, cloud-based GIS, and artificial intelligence (AI) are being applied in this domain. This paper examines and discusses cutting-edge technologies and case studies in different fields of spatial data analytics and crowdsourcing used in a wide range of industries and government departments such as urban planning, health, transportation, and environmental sustainability. Furthermore, by understanding the concerns associated with data quality and data privacy, this paper explores the potential of crowdsourced data while also examining the related problems. This study analyzes the obstacles and challenges related to “geospatial crowdsourcing”, identifying significant limitations and predicting future trends intended to overcome the related challenges. Full article

Hydrogen peroxide (H₂O₂) is a signaling molecule that has the capacity to control a variety of biological processes in organisms. Cancer cells release more H₂O₂ during abnormal tumor growth. There has been a considerable amount of interest in utilizing H₂O₂ as a biomarker for the diagnosis of cancer tissue. In this study, an electrochemical sensor for H₂O₂ was constructed based on 3D reduced graphene oxide (rGO), MXene (Ti₃C₂), and multi-walled carbon nanotubes (MWCNTs) composite. Three-dimensional (3D) rGO–Ti₃C₂–MWCNTs sensor showed good linearity for H₂O₂ in the ranges of 1–60 μM and 60 μM–9.77 mM at a working potential of −0.25 V, with sensitivities of 235.2 µA mM⁻¹ cm⁻² and 103.8 µA mM⁻¹ cm⁻², respectively, and a detection limit of 0.3 µM (S/N = 3). The sensor exhibited long-term stability, good repeatability, and outstanding immunity to interference. In addition, the modified electrode was employed to detect real-time H₂O₂ release from cancer cells and cancer tissue ex vivo. Full article

In the majority of Abhidharmic Buddhist schools, smṛti serves the crucial function of ensuring the recollection of past events and is thus conceptualized as memory in scholarly discourse nowadays. Nevertheless, upon closer examination of various doctrinal perspectives, the interpretation of smṛti diverges significantly among different schools. Notably, it is deemed to be omnipresent in every moment of perception within the Sarvāstivādin tradition, while in Yogācāra, it is regarded as a specific response to an experienced object. This paper seeks to delve into the concept of smṛti within the latter tradition, with a specific focus on the Cheng Weishi Lun (成唯識論, henceforth: CWSL). Drawing upon the foundational principles of Yogācāra doctrine, which posit the ālayavijñāna as an underlying substratum responsible for retaining past information, I contend that smṛti embodies a cognitive faculty that intensifies the apprehension of learned objects when they are present. Furthermore, I argue that smṛti serves as the inception point for a series of cognitive processes acquiring knowledge that helps decision-making. Additionally, I will demonstrate that the function of smṛti in the CWSL diverges from both traditional Buddhist conceptions of memory and contemporary understandings thereof. Full article

The late Roman discourse on divinatory dreams and their interpretation reflects a context of cultural fragmentation. The political turbulence of the 350s to 360s was due partly to the ongoing external war with the (Persian) Sasanians, but also to the internal struggle between the heirs of Constantine for rule over the Roman empire, still undergoing a process of Christianization when Julian was acclaimed Augustus in 360. A third arena of fragmentation was religious beliefs and practices during the 350s and 360s. The contested transformation of Rome in the religious sphere was the context of Julian’s dynastic vision of the two trees, received in late 358 or 359. Full article

Cryopreservation poses significant challenges to the preservation of sperm integrity and function, particularly in small ruminants where cryodamage is pronounced. This review explores the molecular mechanisms underlying sperm cryodamage and strategies for improving cryopreservation outcomes, with a focus on the role of antioxidants. Cryopreservation-induced alterations in proteins and RNA transcripts critical for sperm function, including motility, capacitation, fertilization, and embryo development, are discussed. Proteomic, transcriptomic, and epigenomic advancements have provided valuable insights into these mechanisms, offering potential biomarkers for predicting sperm freezability and enhancing cryopreservation strategies. Combining technologies such as mass spectrometry and flow cytometry allows for a comprehensive understanding of molecular and cellular changes induced by the freezing–thawing process. However, challenges remain in optimizing cryoprotectant formulations and antioxidant supplementation to improve post-thaw sperm fertility. Further research is needed to explore a wider range of novel cryoprotectants, antioxidants, and proteins for cryopreservation media, as well as to validate their efficacy in enhancing sperm viability and function. Additionally, investigations into the effects of cryopreservation on RNA transcripts and epigenetic factors in small ruminant species are warranted to advance our understanding of sperm preservation. Overall, this review highlights the importance of antioxidants in mitigating cryodamage and underscores the need for continued research to refine cryopreservation protocols and improve reproductive outcomes in small ruminants. Full article

Islam is widely spread throughout every corner of China, with the Hui people, the largest Muslim ethnic group in China, numbering over 10 million people, serving as its main carrier. Their culture types and local features exhibit great diversity across different provinces. The ceremony of Prophet’s Day or Mawlid al-Nabi in China, as one of the three fundamental festivals of the Hui people alongside Eid al-Fitur and Eid al-Qurban, appears to be more comprehensive, open, and localized. Drawing from fieldwork in three Hui communities—Xi’an in Shaanxi province, Najiaying in Yunnan province, and Hezhou in Gansu province—this paper approaches the topic from the perspective of inculturation and cultural innovation. It aims to describe the ritual processes observed in these three different Hui communities and discuss how the Hui people integrate Islam with traditional Chinese culture in their local contexts, with the intention of forming and preserving their own cultural characteristics. Full article

The International Regulations for Preventing Collisions at Sea 1972 (COLREGs) have been the cornerstone of maritime navigation since their introduction. Knowledge and implementation of these rules are paramount in collision avoidance at sea. However, terms found in these rules are sometimes imprecise or fuzzy, as they are written by humans for humans, giving them some freedom in interpretation. The term Very Large Ship used in Rule 7 of the COLREGs is, by its nature, fuzzy. While human navigators understand this term’s meaning, it could be challenging for machines or autonomous ships to understand such an unprecise expression. Fuzzy sets could easily describe unprecise terms used in maritime navigation. A fuzzy set consists of elements with degrees of membership in a set, making them perfect for interpreting some terms where boundaries are unclear. This research was conducted among 220 navigational experts to describe linguistic variables used in maritime regulations. This research consists of an internationally distributed questionnaire. Membership data were collected with the adapted horizontal method, and the results were statistically analyzed, followed by regression analyses to describe the range and shape of membership functions. A conceptual model of the implementation of linguistic variables is presented. The novelty of this study derives from the data collecting, modeling, and quantification of the important but neglected linguistic term Very Large Ship based on a large number of navigational experts. The same quantification method could be easily used for other COLREGs linguistic variables, which could easily lift barriers to advances in intelligent solutions based on fuzzy sets. The obtained quantified fuzzy sets can be used in decision support or control systems used by conventional or autonomous ships in the future. Full article

Objective: The aim of the present study was to investigate the possible relationship between the segmental burden of lower limb atherosclerosis and Major Adverse Cardiovascular Events (MACEs). Methods: All the consecutive symptomatic peripheral artery disease (PAD) patients admitted for digital subtraction angiography (DSA) at Turku University Hospital department of Vascular Surgery between 1 January 2009 and 30 July 2011 were retrospectively analyzed. Angiography due to symptomatic PAD was used as the index date for the inclusion in the study. The segmental burden of atherosclerosis based on DSA was divided into three categories according to the highest disease burden of the defined artery segment: aorto-iliac, femoropopliteal, or tibial segments. The major association for the study was MACEs (defined as a cerebrovascular event, heart failure (HF) and myocardial infarction requiring hospital admission). Demographic data and MACEs were obtained from the hospital electronic medical records system. Results. The lower limb atherosclerosis burden of tibial vessels was related to an increased probability for HF (OR 3.9; 95%CI 2.4–6.5) and for MACEs overall (OR 2.3; 95%CI 1.4–3.6). The probability of both HF and MACEs overall rose with the increasing severity of the atherosclerosis burden. Moreover, the more severe the tibial vessel atherosclerosis, the higher the risk of HF and MACEs. The most extensive tibial atherosclerosis patients had an OR 4.5; 95%CI 2.6–8.0 for HF and an OR 3.1; and 95%CI 1.7–5.6 for MACEs overall. The femoropopliteal disease burden was also associated with an increased risk of HF (OR 2.3; 95%CI 1.6–3.2) and MACE (OR 1.9; 95%CI 1.3–2.7). However, the increasing extent of atherosclerosis of the femoropopliteal segment solely increased the risk of MACEs. Conclusions: PAD patients with severe tibial atherosclerosis are likely to present with MACEs. The risk is further enhanced as the extent of tibial vessel atherosclerosis is increased. An association between MACE and severe atherosclerosis on the aortoiliac segment was not detected. However, when the femoropopliteal segment was the most affected artery segment, the risk of MACEs was increased. Full article

In-lab elicitation studies inform the design of gestures by having the participants suggest actions to activate the system functions. Conversely, crowd-sourced identification studies follow the opposite path, asking the users to associate the control actions with functions. Identification studies have been used to validate the gestures produced by elicitation studies, but not to design interactive systems. In this paper, we show that identification studies can be combined with in situ observations to design the gestures for data exploration with public displays. To illustrate this method, we developed two versions of a gesture-controlled system for data exploration with 368 users: one designed through an elicitation study, and one designed through in situ observations followed by an identification study. Our results show that the users discovered the majority of the gestures with similar accuracy across the two prototypes. Additionally, the in situ approach enabled the direct recruitment of target users, and the crowd-sourced approach typical of identification studies expedited the design process. Full article

High-rise timber residential towers (≥eight-stories) represent a burgeoning and auspicious sector, predominantly due to their capability to provide significant ecological and financial advantages throughout their lifecycle. Like numerous other building types, spatial optimization in high-rise timber residential structures stands as a pivotal design factor essential for project viability. Presently, there exists no comprehensive investigation on space efficiency in such towers. This study analyzed data from 51 case studies to enhance understanding of the design considerations influencing space efficiency in high-rise timber residential towers. Key findings included (1) the average space efficiency within the examined cases was recorded at 83%, exhibiting variances ranging from 70% to 93% across different cases, (2) the average percentage of core area to gross floor area (GFA) was calculated at 10%, demonstrating fluctuations within the range of 4% to 21% across diverse scenarios, and (3) no notable distinction was observed in the effect of various core planning strategies on spatial efficiency when properly designed, and similar conclusions were drawn regarding building forms and structural materials. This research will aid in formulating design guidelines tailored for various stakeholders such as architectural designers involved in high-rise residential timber building developments. Full article