The 2023 MDPI Annual Report has
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19 pages, 8046 KiB  
Article
Sensitivity Analysis of Modal Parameters of an RC Joint Subject to Progressive Damage under Cyclic Loads
by Amedeo Gregori, Lorenzo Bizzarri, Caterina D’Agostino, Angelo Aloisio, Riccardo Cirella and Rocco Alaggio
Buildings 2024, 14(5), 1345; https://doi.org/10.3390/buildings14051345 (registering DOI) - 9 May 2024
Abstract
This paper presents the results of an experimental study that focused on the gradual modification of the modal parameters of reinforced concrete beam–column frames subjected to progressive damage under cyclic loading. As is commonly found in structures of the 1970s, the specimen was [...] Read more.
This paper presents the results of an experimental study that focused on the gradual modification of the modal parameters of reinforced concrete beam–column frames subjected to progressive damage under cyclic loading. As is commonly found in structures of the 1970s, the specimen was characterized by the absence of specific shear reinforcement in the nodal panel. The frame modal parameters were investigated using the ambient vibrations test (AVT) as a modal identification technique. In particular, quasi-static cyclic tests with increasing amplitudes were performed on the reinforced concrete frame specimen and the modal parameters were assessed at various stages of frame degradation. By establishing a correlation between the changes in the modal parameters and the mechanical indicators of the structural damage in the frame, this study aimed to determine whether the ambient vibration tests could offer meaningful insights for evaluating the structural health of this type of structural component. As a result of the damage that occurred in the tested RC frame, the residual experimental value of the first natural frequency of the specimen was found to reduce at 52.7% of the original reference value (undamaged stage). Similarly, the residual value of the frame stiffness was found to be as low as 43.82% of the initial one. Both these results confirmed that changes when monitoring the modal frequencies may provide quantitative indexes to describe the structural health of RC frames. In combination with static tests for a direct measure of the structural stiffness variations, the AVT technique was shown to have interesting potential in detecting the type, level, and distribution of the progressive damage in civil structures. In particular, exponential and polynomial regression curves were defined to describe the decay of the first natural frequency as the structural damage increased in various parts of the frame, and it was shown that the variation in the first natural frequency was determined more by the damage on the beam than by the damage on the joint. Full article
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12 pages, 334 KiB  
Article
New Properties of Analytic Functions
by Hatun Özlem Güney and Shigeyoshi Owa
Mathematics 2024, 12(10), 1469; https://doi.org/10.3390/math12101469 (registering DOI) - 9 May 2024
Abstract
In the present paper, we consider the class A¯ of functions f(z) of the form f(z)=z+k=1a1+k3z1+k3 that are [...] Read more.
In the present paper, we consider the class A¯ of functions f(z) of the form f(z)=z+k=1a1+k3z1+k3 that are analytic in the open unit disc U. If a1+k3=0 for k3n(n=1,2,3,), then f(z) is given by f(z)=z+k=2akzk. For such functions f(z)A¯, some interesting properties for subordinations and strongly starlike functions are given. Also, some interesting examples for the results are shown. Full article
(This article belongs to the Special Issue Complex Analysis and Geometric Function Theory, 2nd Edition)
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10 pages, 1671 KiB  
Article
Mapping the Land Use Changes in Cultivation Areas of Maize and Soybean from 2006 to 2017 in the North West and Free State Provinces, South Africa
by Siphokazi Ngcinela, Abbyssinia Mushunje, Amon Taruvinga, Shelton Charles Mutengwa and Samuel Tlou Masehela
Agronomy 2024, 14(5), 1002; https://doi.org/10.3390/agronomy14051002 (registering DOI) - 9 May 2024
Abstract
Land use practices face significant pressure due to increased demand and conflicting needs. Several factors contribute to this trend, such as the ever-increasing human population, the increased demand for food production, and the expansion of industrial and agricultural areas. This paper, focused on [...] Read more.
Land use practices face significant pressure due to increased demand and conflicting needs. Several factors contribute to this trend, such as the ever-increasing human population, the increased demand for food production, and the expansion of industrial and agricultural areas. This paper, focused on the cultivation patterns and investigating changes in land use of maize and soybean over time (i.e., both genetically modified and non-genetically modified) in two South African provinces. The objective was to determine whether there was a net increase or decrease in land cover age for these two crops between 2006 and 2017 in the selected study areas. Hence, the study utilized ArcGIS (10.8.1) software to quantify and map the land used for the cultivation of maize and soybean from 2006 to 2017 in Free State and North West provinces. The results show both provinces to have minimal expansion or change in cultivation areas for both maize and soybean between 2006 and 2017. We concluded that both maize and soybean cultivation areas in these provinces, did not expand beyond the current agricultural areas (space), and did not encroach onto new land areas. As a result, both maize and soybean do not currently pose a threat to the surrounding landscape (i.e., natural vegetation) and are not in direct competition with other neighboring land use practices. We recommend that data on the annual planting or cultivation area be consistently gathered, analyzed, and mapped to monitor any alterations that could influence the current findings. This will also assist with any land use planning and management practices. Full article
(This article belongs to the Section Farming Sustainability)
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17 pages, 3794 KiB  
Article
Stretch Causes cffDNA and HMGB1-Mediated Inflammation and Cellular Stress in Human Fetal Membranes
by Justin Gary Padron, Chelsea A Saito Reis, Po’okela K. Ng, Nainoa D. Norman Ing, Hannah Baker, Kamalei Davis, Courtney Kurashima and Claire E. Kendal-Wright
Int. J. Mol. Sci. 2024, 25(10), 5161; https://doi.org/10.3390/ijms25105161 (registering DOI) - 9 May 2024
Abstract
Danger-associated molecular patterns (DAMPs) are elevated within the amniotic cavity, and their increases correlate with advancing gestational age, chorioamnionitis, and labor. Although the specific triggers for their release in utero remain unclear, it is thought that they may contribute to the initiation of [...] Read more.
Danger-associated molecular patterns (DAMPs) are elevated within the amniotic cavity, and their increases correlate with advancing gestational age, chorioamnionitis, and labor. Although the specific triggers for their release in utero remain unclear, it is thought that they may contribute to the initiation of parturition by influencing cellular stress mechanisms that make the fetal membranes (FMs) more susceptible to rupture. DAMPs induce inflammation in many different tissue types. Indeed, they precipitate the subsequent release of several proinflammatory cytokines that are known to be key for the weakening of FMs. Previously, we have shown that in vitro stretch of human amnion epithelial cells (hAECs) induces a cellular stress response that increases high-mobility group box-1 (HMGB1) secretion. We have also shown that cell-free fetal DNA (cffDNA) induces a cytokine response in FM explants that is fetal sex-specific. Therefore, the aim of this work was to further investigate the link between stretch and the DAMPs HMGB1 and cffDNA in the FM. These data show that stretch increases the level of cffDNA released from hAECs. It also confirms the importance of the sex of the fetus by demonstrating that female cffDNA induced more cellular stress than male fetuses. Our data treating hAECs and human amnion mesenchymal cells with HMGB1 show that it has a differential effect on the ability of the cells of the amnion to upregulate the proinflammatory cytokines and propagate a proinflammatory signal through the FM that may weaken it. Finally, our data show that sulforaphane (SFN), a potent activator of Nrf2, is able to mitigate the proinflammatory effects of stretch by decreasing the levels of HMGB1 release and ROS generation after stretch and modulating the increase of key cytokines after cell stress. HMGB1 and cffDNA are two of the few DAMPs that are known to induce cytokine release and matrix metalloproteinase (MMP) activation in the FMs; thus, these data support the general thesis that they can function as potential central players in the normal mechanisms of FM weakening during the normal distension of this tissue at the end of a normal pregnancy. Full article
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11 pages, 3091 KiB  
Article
ABCG2 Mediates Resistance to the Dual EGFR and PI3K Inhibitor MTX-211 in Cancer Cells
by Chung-Pu Wu, Cheng-Yu Hung, Megumi Murakami, Yu-Shan Wu, Yi-Hsuan Chu, Yang-Hui Huang, Jau-Song Yu and Suresh V. Ambudkar
Int. J. Mol. Sci. 2024, 25(10), 5160; https://doi.org/10.3390/ijms25105160 (registering DOI) - 9 May 2024
Abstract
MTX-211 is a first-in-class dual inhibitor of epidermal growth factor receptor (EGFR) and phosphoinositide-3 kinase (PI3K) signaling pathways with a compelling pharmaceutical profile and could enhance the effectiveness of mitogen-activated protein kinase kinase (MEK) inhibitor therapy in colorectal tumors with KRAS mutations. However, [...] Read more.
MTX-211 is a first-in-class dual inhibitor of epidermal growth factor receptor (EGFR) and phosphoinositide-3 kinase (PI3K) signaling pathways with a compelling pharmaceutical profile and could enhance the effectiveness of mitogen-activated protein kinase kinase (MEK) inhibitor therapy in colorectal tumors with KRAS mutations. However, the specific mechanisms contributing to the acquired resistance to MTX-211 in human cancers remain elusive. Here, we discovered that the overexpression of the ATP-binding cassette (ABC) drug transporter ABCG2, a prevalent mechanism associated with multidrug resistance (MDR), could diminish the effectiveness of MTX-211 in human cancer cells. We showed that the drug efflux activity of ABCG2 substantially decreased the intracellular accumulation of MTX-211 in cancer cells. As a result, the cytotoxicity and effectiveness of MTX-211 in suppressing the activation of the EGFR and PI3K pathways were significantly attenuated in cancer cells overexpressing ABCG2. Moreover, the enhancement of the MTX-211-stimulated ATPase activity of ABCG2 and the computational molecular docking analysis illustrating the binding of MTX-211 to the substrate-binding sites of ABCG2 offered a further indication for the interaction between MTX-211 and ABCG2. In summary, our findings indicate that MTX-211 acts as a substrate for ABCG2, underscoring the involvement of ABCG2 in the emergence of resistance to MTX-211. This finding carries clinical implications and merits further exploration. Full article
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12 pages, 1576 KiB  
Article
Enhancing the Extraction of Phenolic Antioxidants from Amazonian Assai (Euterpe oleracea Martius) Fruit Waste through Response Surface Methodology Optimization
by Yasmin Cunha-Silva, David Dias, Luiz Felipe Ravazi Pereira, Carlos Victor Lamarão Pereira, Emerson Silva Lima, Klenicy Kazumy de Lima Yamaguchi and Valdir Florêncio da Veiga-Junior
Biomass 2024, 4(2), 402-413; https://doi.org/10.3390/biomass4020019 (registering DOI) - 9 May 2024
Abstract
Assai (Euterpe oleracea Martius) is a superfruit widely consumed in several countries, mainly produced in the Amazon region. The significant growth of the market for this fruit has raised environmental concerns regarding the disposal of production waste, especially the seeds that are [...] Read more.
Assai (Euterpe oleracea Martius) is a superfruit widely consumed in several countries, mainly produced in the Amazon region. The significant growth of the market for this fruit has raised environmental concerns regarding the disposal of production waste, especially the seeds that are not utilized and represent approximately 80% of the fruit. In the present study, strategies were developed for transforming these seed wastes into new products, using green solvents for extraction under conditions conducive to technology transfer and with feasible quality control through simple bench techniques, which represents an ideal approach for establishing a truly sustainable process. A significant interaction between solvent and extraction method was observed, impacting both yields and total phenols. Phenolic compounds are substances known for their health benefits, functioning as antioxidants and consequently aiding in disease prevention. The phenolic content observed in the extractions increased from 22.68% to 44.74% under optimal conditions during extraction via hot maceration (50 °C) in 100% ethanol for 2 h, which also enhanced yield and increased antioxidant capacity. The extracts displayed remarkable free radical scavenging activities (IC50 = 6.54 μg/mL in ABTS and IC50 = 14.71 μg/mL in DPPH), approaching the Trolox and quercetin standards, respectively. The optimized method paved the way for the industrial-scale utilization of the residues of this valuable Amazonian fruit. Full article
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20 pages, 5328 KiB  
Article
Effects of Environment Change Scenarios on the Potential Geographical Distribution of Cunninghamia lanceolata (Lamb.) Hook. in China
by Jiajie Feng, Yiwei Cao, Teja Manda, Delight Hwarari, Jinhui Chen and Liming Yang
Forests 2024, 15(5), 830; https://doi.org/10.3390/f15050830 (registering DOI) - 9 May 2024
Abstract
Changes in climate and environmental conditions have aggravated the severity and unpredictability of plant survival and growth. Cunninghamia lanceolata (Lamb.) Hook. is an economically important timber tree. Exploring its potential distribution and dynamic changes and identifying the leading environmental variables affecting it will [...] Read more.
Changes in climate and environmental conditions have aggravated the severity and unpredictability of plant survival and growth. Cunninghamia lanceolata (Lamb.) Hook. is an economically important timber tree. Exploring its potential distribution and dynamic changes and identifying the leading environmental variables affecting it will help to adjust the planting range reasonably according to the habits and climate change, thus contributing to its survival and growth. Based on the MaxEnt model and ArcGIS tool, climate, soil, terrain, human activities, variable environment layers, and 395 C. lanceolata distribution points were used to simulate and analyze the geographical distribution characteristics of C. lanceolata in the current and future periods (the 2050s and 2070s) under RCP2.6, RCP4.5, RCP6.0, and RCP8.5. The results showed that C. lanceolata was suitable to grow in a subtropical monsoon climate with warm, humid, abundant rainfall and a relatively gentle topography. Additionally, using percent contribution, permutation importance, and the knife-cutting test, we noted that the annual precipitation (Bio12), human activities (Hfp), minimum temperature of the coldest month (Bio6), mean temperature of the coldest quarter (Bio11), precipitation of coldest quarter (Bio19), annual temperature range (Bio7), and elevation were the leading environmental factors affecting the geographical distribution of C. lanceolata. Among them, it should be noted that the impact of human activities was negatively correlated with suitable habitat areas of C. lanceolata and led to the degeneration of suitable habitats and fragmentized distribution. In addition, predictions have shown that the areas of habitats under other scenarios will be characterized by an increasing and then decreasing trend by the 2050s and 2070s, except for the RCP2.6 scenario, under which the suitable habitats area of C. lanceolata will increase continuously. The core distributional shifts showed that the suitable habitats of C. lanceolata will gradually shift and migrate to high-latitude areas due to global warming. This study focused on the characteristics of suitable habitats of C. lanceolata under different climatic scenarios using more environmental factors and scenarios than before, aiming to provide a theoretical basis and guidance for the management and utilization of forest resources, the planning of suitable planting areas, and germplasm protection. Full article
(This article belongs to the Special Issue Modeling Forest Response to Climate Change)
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13 pages, 2901 KiB  
Article
Liquid Chromatography–Mass Spectrometry-Based Metabolomics Reveals Dynamic Metabolite Changes during Early Postmortem Aging of Donkey Meat
by Wenqiong Chai, Liyuan Wang, Tong Li, Tianqi Wang, Xinrui Wang, Miao Yan, Mingxia Zhu, Jingrong Gao, Changfa Wang, Qiugang Ma and Honglei Qu
Foods 2024, 13(10), 1466; https://doi.org/10.3390/foods13101466 (registering DOI) - 9 May 2024
Abstract
Background: Metabolic changes in donkey meat during the early postmortem period have not been previously reported. Methods: The LC–MS-based metabolomics technique was conducted to understand the metabolic profiles and identify the key metabolites of donkey meat in the first 48 h postmortem. Results: [...] Read more.
Background: Metabolic changes in donkey meat during the early postmortem period have not been previously reported. Methods: The LC–MS-based metabolomics technique was conducted to understand the metabolic profiles and identify the key metabolites of donkey meat in the first 48 h postmortem. Results: The pH values showed a decreasing trend followed by an increasing trend. Shear force was the lowest at 4 h and the highest at 24 h (p < 0.05). For the metabolome, some candidate biomarker metabolites were identified, such as adenine, inosine, n-acetylhistidine, citric acid, isocitrate, and malic acid. Predominant metabolic pathways, such as citrate cycle (TCA cycle), alanine, aspartate and glutamate metabolism, and purine metabolism, were affected by aging time. Overabundant n-acetylhistidine was identified in LT, declined at 12 h postmortem aging, and then increased. This may explain the significantly lower pH at 12 h postmortem. Adenine was higher at 4 h postmortem, then declined. Decreased ADP may indicate a fast consumption of ATP and subsequent purine metabolism in donkey meat. Conclusions: The results of this study provided new insights into early postmortem aging of donkey meat quality. Full article
(This article belongs to the Section Meat)
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27 pages, 866 KiB  
Article
An Improved Dung Beetle Optimization Algorithm for High-Dimension Optimization and Its Engineering Applications
by Xu Wang, Hongwei Kang, Yong Shen, Xingping Sun and Qingyi Chen
Symmetry 2024, 16(5), 586; https://doi.org/10.3390/sym16050586 (registering DOI) - 9 May 2024
Abstract
One of the limitations of the dung beetle optimization (DBO) is its susceptibility to local optima and its relatively low search accuracy. Several strategies have been utilized to improve the diversity, search precision, and outcomes of the DBO. However, the equilibrium between exploration [...] Read more.
One of the limitations of the dung beetle optimization (DBO) is its susceptibility to local optima and its relatively low search accuracy. Several strategies have been utilized to improve the diversity, search precision, and outcomes of the DBO. However, the equilibrium between exploration and exploitation has not been achieved optimally. This paper presents a novel algorithm called the ODBO, which incorporates cat map and an opposition-based learning strategy, which is based on symmetry theory. In addition, in order to enhance the performance of the dung ball rolling phase, this paper combines the global search strategy of the osprey optimization algorithm with the position update strategy of the DBO. Additionally, we enhance the population’s diversity during the foraging phase of the DBO by incorporating vertical and horizontal crossover of individuals. This introduction of asymmetry in the crossover operation increases the exploration capability of the algorithm, allowing it to effectively escape local optima and facilitate global search. Full article
(This article belongs to the Section Computer)
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13 pages, 629 KiB  
Article
Burning Mouth Syndrome Treated with Low-Level Laser and Clonazepam: A Randomized, Single-Blind Clinical Trial
by Ana Garcia Martinez, Pia Lopez-Jornet, Luis Pardo Marin, Eduardo Pons-Fuster and Asta Tvarijonaviciute
Biomedicines 2024, 12(5), 1048; https://doi.org/10.3390/biomedicines12051048 (registering DOI) - 9 May 2024
Abstract
Objective: Burning mouth syndrome (BMS) is a chronic pain disorder characterized by intraoral burning or dysaesthetic sensation, with the absence of any identifiable lesions. Numerous treatments for BMS have been investigated, though without conclusive results. An analysis was conducted of the efficacy of [...] Read more.
Objective: Burning mouth syndrome (BMS) is a chronic pain disorder characterized by intraoral burning or dysaesthetic sensation, with the absence of any identifiable lesions. Numerous treatments for BMS have been investigated, though without conclusive results. An analysis was conducted of the efficacy of treatment with a low-level diode laser and clonazepam in patients with BMS, and a study was carried out on the levels of different salivary biomarkers before and after treatment. Material and methods: A randomized, single-blind clinical trial was carried out involving 89 patients divided into the following groups: group 1 (laser, The Helbo® Theralite Laser 3D Pocket Probe + clonazepam) (n = 20), group 2 (sham laser placebo) (n = 19), group 3 (laser) (n = 21) and group 4 (clonazepam) (n = 18). Symptom intensity was scored based on a visual analogue scale (VAS). Sialometry was performed before and after treatment, and the Xerostomia Inventory, Oral Health Impact Profile-14 (OHIP-14) and Mini-Nutritional Assessment (MNA) questionnaires were administered. The following markers were measured in saliva samples: interleukins (IL2, IL4, IL5, IL6, IL7, IL8, IL1β, IL10, IL12, IL13, IL17, IL21 and IL23), proteins (MIP-3α, MIP-1α and MIP-1β), GM-CSF, interferon gamma (IFNγ), interferon-inducible T-cell alpha chemoattractant (ITAC), fractalkine and tumor necrosis factor α (TNFα). Results: A significant decrease in the VAS scores was observed after treatment in group 1 (laser + clonazepam) (p = 0.029) and group 3 (laser) (p = 0.005). In turn, group 3 (laser) showed a decrease in the salivary concentration of fractalkine (p = 0.025); interleukins IL12 (p = 0.048), IL17 (p = 0.020), IL21 (p = 0.008), IL7 (p = 0.001) and IL8 (p = 0.007); proteins MIP1α (p = 0.048) and MIP1β (p = 0.047); and TNFα (p = 0.047) versus baseline. Following treatment, group 1 (laser + clonazepam) showed significant differences in IL21 (p = 0.045) and IL7 (p = 0.009) versus baseline, while group 4 (clonazepam) showed significant differences in IL13 (p = 0.036), IL2 (p = 0.020) and IL4 (p = 0.001). No significant differences were recorded in group 2 (sham laser placebo). Conclusions: The low-level diode laser is a good treatment option in BMS, resulting in a decrease in patient symptoms and in salivary biomarkers. However, standardization of the intervention protocols and laser intensity parameters is needed in order to draw more firm conclusions. Full article
(This article belongs to the Section Molecular Genetics and Genetic Diseases)
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21 pages, 2929 KiB  
Article
Pinus thunbergii Parl. Somatic Plants’ Resistance to Bursaphelenchus xylophilus Depends on Pathogen-Induced Differential Transcriptomic Responses
by Tingyu Sun, Yahui Wang, Xiaoqin Wu, Yang Wang, Aixia Yang and Jianren Ye
Int. J. Mol. Sci. 2024, 25(10), 5156; https://doi.org/10.3390/ijms25105156 (registering DOI) - 9 May 2024
Abstract
Pinus thunbergii Parl. is an economically and medicinally important plant, as well as a world-renowned horticultural species of the Pinus genus. Pine wilt disease is a dangerous condition that affects P. thunbergii. However, understanding of the genetics underlying resistance to this disease [...] Read more.
Pinus thunbergii Parl. is an economically and medicinally important plant, as well as a world-renowned horticultural species of the Pinus genus. Pine wilt disease is a dangerous condition that affects P. thunbergii. However, understanding of the genetics underlying resistance to this disease is poor. Our findings reveal that P. thunbergii’s resistance mechanism is based on differential transcriptome responses generated by the early presence of the pathogen Bursaphelenchus xylophilus, also known as the pine wood nematode. A transcriptome analysis (RNA-seq) was performed to examine gene expression in shoot tissues from resistant and susceptible P. thunbergii trees. RNA samples were collected from the shoots of inoculated pines throughout the infection phases by the virulent Bursaphelenchus xylophilus AMA3 strain. The photosynthesis and plant–pathogen interaction pathways were significantly enriched in the first and third days after infection. Flavonoid biosynthesis was induced in response to late infestation (7 and 14 days post-infestation). Calmodulin, RBOH, HLC protein, RPS, PR1, and genes implicated in phytohormone crosstalk (e.g., SGT1, MYC2, PP2C, and ERF1) showed significant alterations between resistant and susceptible trees. Furthermore, salicylic acid was found to aid pine wood nematodes tolerate adverse conditions and boost reproduction, which may be significant for pine wood nematode colonization within pines. These findings provide new insights into how host defenses overcame pine wood nematode infection in the early stage, which could potentially contribute to the development of novel strategies for the control of pine wilt disease. Full article
(This article belongs to the Special Issue Advances in Forest Tree Physiology, Breeding and Genetic Research)
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18 pages, 1228 KiB  
Article
Study of the Six-Compartment Nonlinear COVID-19 Model with the Homotopy Perturbation Method
by Muhammad Rafiullah, Muhammad Asif, Dure Jabeen and Mahmoud A. Ibrahim
Axioms 2024, 13(5), 311; https://doi.org/10.3390/axioms13050311 (registering DOI) - 9 May 2024
Abstract
The current study aims to utilize the homotopy perturbation method (HPM) to solve nonlinear dynamical models, with a particular focus on models related to predicting and controlling pandemics, such as the SIR model. Specifically, we apply this method to solve a six-compartment model [...] Read more.
The current study aims to utilize the homotopy perturbation method (HPM) to solve nonlinear dynamical models, with a particular focus on models related to predicting and controlling pandemics, such as the SIR model. Specifically, we apply this method to solve a six-compartment model for the novel coronavirus (COVID-19), which includes susceptible, exposed, asymptomatic infected, symptomatic infected, and recovered individuals, and the concentration of COVID-19 in the environment is indicated by S(t), E(t), A(t), I(t), R(t), and B(t), respectively. We present the series solution of this model by varying the controlling parameters and representing them graphically. Additionally, we verify the accuracy of the series solution (up to the (n1)th-degree polynomial) that satisfies both the initial conditions and the model, with all coefficients correct at 18 decimal places. Furthermore, we have compared our results with the Runge–Kutta fourth-order method. Based on our findings, we conclude that the homotopy perturbation method is a promising approach to solve nonlinear dynamical models, particularly those associated with pandemics. This method provides valuable insight into how the control of various parameters can affect the model. We suggest that future studies can expand on our work by exploring additional models and assessing the applicability of other analytical methods. Full article
(This article belongs to the Special Issue Dynamical Systems: Theory and Applications in Mathematical Biology)
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16 pages, 7443 KiB  
Article
Anti-Oxidized Self-Assembly of Multilayered F-Mene/MXene/TPU Composite with Improved Environmental Stability and Pressure Sensing Performances
by Zhong Zheng, Qian Yang, Shuyi Song, Yifan Pan, Huan Xue and Jing Li
Polymers 2024, 16(10), 1337; https://doi.org/10.3390/polym16101337 (registering DOI) - 9 May 2024
Abstract
MXenes, as emerging 2D sensing materials for next-generation electronics, have attracted tremendous attention owing to their extraordinary electrical conductivity, mechanical strength, and flexibility. However, challenges remain due to the weak stability in the oxygen environment and nonnegligible aggregation of layered MXenes, which severely [...] Read more.
MXenes, as emerging 2D sensing materials for next-generation electronics, have attracted tremendous attention owing to their extraordinary electrical conductivity, mechanical strength, and flexibility. However, challenges remain due to the weak stability in the oxygen environment and nonnegligible aggregation of layered MXenes, which severely affect the durability and sensing performances of the corresponding MXene-based pressure sensors, respectively. Here, in this work, we propose an easy-to-fabricate self-assembly strategy to prepare multilayered MXene composite films, where the first layer MXene is hydrogen-bond self-assembled on the electrospun thermoplastic urethane (TPU) fibers surface and the anti-oxidized functionalized-MXene (f-MXene) is subsequently adhered on the MXene layer by spontaneous electrostatic attraction. Remarkably, the f-MXene surface is functionalized with silanization reagents to form a hydrophobic protective layer, thus preventing the oxidation of the MXene-based pressure sensor during service. Simultaneously, the electrostatic self-assembled MXene and f-MXene successfully avoid the invalid stacking of MXene, leading to an improved pressure sensitivity. Moreover, the adopted electrospinning method can facilitate cyclic self-assembly and the formation of a hierarchical micro-nano porous structure of the multilayered f-MXene/MXene/TPU (M-fM2T) composite. The gradient pores can generate changes in the conductive pathways within a wide loading range, broadening the pressure detection range of the as-proposed multilayered f-MXene/MXene/TPU piezoresistive sensor (M-fM2TPS). Experimentally, these novel features endow our M-fM2TPS with an outstanding maximum sensitivity of 40.31 kPa−1 and an extensive sensing range of up to 120 kPa. Additionally, our M-fM2TPS exhibits excellent anti-oxidized properties for environmental stability and mechanical reliability for long-term use, which shows only ~0.8% fractional resistance changes after being placed in a natural environment for over 30 days and provides a reproducible loading–unloading pressure measurement for more than 1000 cycles. As a proof of concept, the M-fM2TPS is deployed to monitor human movements and radial artery pulse. Our anti-oxidized self-assembly strategy of multilayered MXene is expected to guide the future investigation of MXene-based advanced sensors with commercial values. Full article
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12 pages, 13289 KiB  
Article
Setting Plasma Immersion Ion Implantation of Ar+ Parameters towards Electroforming-Free and Self-Compliance HfO2-Based Memristive Structures
by Olga Permiakova, Sergey Pankratov, Alexandr Isaev, Andrew Miakonkikh, Yuri Chesnokov, Andrey Lomov and Alexander Rogozhin
Nanomaterials 2024, 14(10), 831; https://doi.org/10.3390/nano14100831 (registering DOI) - 9 May 2024
Abstract
Memristive structures are among the most promising options to be components of neuromorphic devices. However, the formation of HfO2-based devices in crossbar arrays requires considerable time since electroforming is a single stochastic operation. In this study, we investigate how Ar+ [...] Read more.
Memristive structures are among the most promising options to be components of neuromorphic devices. However, the formation of HfO2-based devices in crossbar arrays requires considerable time since electroforming is a single stochastic operation. In this study, we investigate how Ar+ plasma immersion ion implantation (PI) affects the Pt/HfO2 (4 nm)/HfOXNY (3 nm)/TaN electroforming voltage. The advantage of PI is the simultaneous and uniform processing of the entire wafer. It is thought that Ar+ implantation causes defects to the oxide matrix, with the majority of the oxygen anions being shifted in the direction of the TaN electrode. We demonstrate that it is feasible to reduce the electroforming voltages from 7.1 V to values less than 3 V by carefully selecting the implantation energy. A considerable decrease in the electroforming voltage was achievable at an implantation energy that provided the dispersion of recoils over the whole thickness of the oxide without significantly affecting the HfOXNY/TaN interface. At the same time, Ar+ PI at higher and lower energies did not produce the same significant decrease in the electroforming voltage. It is also possible to obtain self-compliance of current in the structure during electroforming after PI with energy less than 2 keV. Full article
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18 pages, 3736 KiB  
Article
Bovine Serum Albumin Effect on Collapsing PNIPAM Chains in Aqueous Solutions: Spin Label and Spin Probe Study
by Georgii A. Simenido, Ekaterina M. Zubanova, Evgenii A. Ksendzov, Sergei V. Kostjuk, Peter S. Timashev and Elena N. Golubeva
Polymers 2024, 16(10), 1335; https://doi.org/10.3390/polym16101335 (registering DOI) - 9 May 2024
Abstract
The influence of bovine serum albumin (BSA) on collapsing poly(N-isopropylacrylamide) (PNIPAM) chains was studied with turbidimetry and spin probe and spin label electron paramagnetic resonance spectroscopy. An increased ratio of collapsed chains in aqueous solutions in the narrow temperature region near [...] Read more.
The influence of bovine serum albumin (BSA) on collapsing poly(N-isopropylacrylamide) (PNIPAM) chains was studied with turbidimetry and spin probe and spin label electron paramagnetic resonance spectroscopy. An increased ratio of collapsed chains in aqueous solutions in the narrow temperature region near the LCST appeared in the presence of 2.5–10 wt% BSA. The spin probe EPR data indicate that the inner cavities of the BSA dimers are probably responsive to the capture of small hydrophobic or amphiphilic molecules, such as TEMPO nitroxyl radical. The observed features of the structure and dynamics of inhomogeneities of aqueous PNIPAM-BSA solutions, including their mutual influence on the behavior of the polymer and protein below the LCST, should be considered when developing and investigating PNIPAM-based drug delivery systems. Full article
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19 pages, 791 KiB  
Review
Plate Food Waste in Food Services: A Systematic Review and Meta-Analysis
by Nathalia Sernizon Guimarães, Marcela Gomes Reis, Luciano de Alvarenga Fontes, Renata Puppin Zandonadi, Raquel Braz Assunção Botelho, Hmidan A. Alturki, Ariana Saraiva and António Raposo
Nutrients 2024, 16(10), 1429; https://doi.org/10.3390/nu16101429 (registering DOI) - 9 May 2024
Abstract
Food waste is considered to be a social, environmental, administrative, and economic problem. Given the large-scale production and distribution of food, food waste in food services has been widely discussed by experts, professors, and scientists in the field. This systematic review aimed to [...] Read more.
Food waste is considered to be a social, environmental, administrative, and economic problem. Given the large-scale production and distribution of food, food waste in food services has been widely discussed by experts, professors, and scientists in the field. This systematic review aimed to understand which food service has the highest percentage of plate food waste. A systematic review and meta-analysis were conducted until January 2024 in ten electronic databases: MEDLINE, Embase, IBECS, BINACIS, BDENF, CUMED, BDNPAR, ARGMSAL, Cochrane Library, Sustainable Development Goals, and the gray literature. The protocol was previously registered with PROSPERO under the code CRD42024501971. Studies that have assessed plate food waste in food services were included. There were no restrictions on language, publication location, or date. The risk of bias analysis was carried out using the JBI instrument. A proportion meta-analysis was carried out using R software (version 4.2.1). This systematic review with meta-analysis showed that the type of distribution and the food service are the factors that have the greatest impact on the percentage and per capita of plate food waste. In the face of increased waste, interventions should be targeted by type and distribution system, diners, and meals in order to lessen the impact of these factors. Full article
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16 pages, 2240 KiB  
Article
The Influence of a Polyphenol-Rich Red Berry Fruit Juice on Recovery Process and Leg Strength Capacity after Six Days of Intensive Endurance Exercise in Recreational Endurance Athletes
by Sarah Valder, Elisabeth Habersatter, Tihomir Kostov, Sina Quenzer, Lukas Herzig, Jakob von Bernuth, Lynn Matits, Volker Herdegen, Patrick Diel and Eduard Isenmann
Nutrients 2024, 16(10), 1428; https://doi.org/10.3390/nu16101428 (registering DOI) - 9 May 2024
Abstract
Background: Various nutritional strategies are increasingly used in sports to reduce oxidative stress and promote recovery. Chokeberry is rich in polyphenols and can reduce oxidative stress. Consequently, chokeberry juices and mixed juices with chokeberry content are increasingly used in sports. However, the data [...] Read more.
Background: Various nutritional strategies are increasingly used in sports to reduce oxidative stress and promote recovery. Chokeberry is rich in polyphenols and can reduce oxidative stress. Consequently, chokeberry juices and mixed juices with chokeberry content are increasingly used in sports. However, the data are very limited. Therefore, this study investigates the effects of the short-term supplementation of a red fruit juice drink with chokeberry content or a placebo on muscle damage, oxidative status, and leg strength during a six-day intense endurance protocol. Methods: Eighteen recreational endurance athletes participated in a cross-over high intensity interval training (HIIT) design, receiving either juice or a placebo. Baseline and post-exercise assessments included blood samples, anthropometric data, and leg strength measurements. Results: A significant increase was measured in muscle damage following the endurance protocol in all participants (∆ CK juice: 117.12 ± 191.75 U/L, ∆ CK placebo: 164.35 ± 267.00 U/L; p = 0.001, η2 = 0.17). No group effects were detected in exercise-induced muscle damage (p = 0.371, η2 = 0.010) and oxidative status (p = 0.632, η2 = 0.000). The reduction in strength was stronger in the placebo group, but group effects are missing statistical significance (∆ e1RM juice: 1.34 ± 9.26 kg, ∆ e1RM placebo: −3.33 ± 11.49 kg; p = 0.988, η2 = 0.000). Conclusion: Although a reduction in strength can be interpreted for the placebo treatment, no statistically significant influence of chokeberry could be determined. It appears that potential effects may only occur with prolonged application and a higher content of polyphenols, but further research is needed to confirm this. Full article
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30 pages, 7313 KiB  
Article
Rapid Approximation of Low-Thrust Spacecraft Reachable Sets within Complex Two-Body and Cislunar Dynamics
by Sean Bowerfind and Ehsan Taheri
Aerospace 2024, 11(5), 380; https://doi.org/10.3390/aerospace11050380 (registering DOI) - 9 May 2024
Abstract
The reachable set of controlled dynamical systems is the set of all reachable states from an initial condition over a certain time horizon, subject to operational constraints and exogenous disturbances. In astrodynamics, rapid approximation of reachable sets is invaluable for trajectory planning, collision [...] Read more.
The reachable set of controlled dynamical systems is the set of all reachable states from an initial condition over a certain time horizon, subject to operational constraints and exogenous disturbances. In astrodynamics, rapid approximation of reachable sets is invaluable for trajectory planning, collision avoidance, and ensuring safe and optimal performance in complex dynamics. Leveraging the connection between minimum-time trajectories and the boundary of reachable sets, we propose a sampling-based method for rapid and efficient approximation of reachable sets for finite- and low-thrust spacecraft. The proposed method combines a minimum-time multi-stage indirect formulation with the celebrated primer vector theory. Reachable sets are generated under two-body and circular restricted three-body (CR3B) dynamics. For the two-body dynamics, reachable sets are generated for (1) the heliocentric phase of a benchmark Earth-to-Mars problem, (2) two scenarios with uncertainties in the initial position and velocity of the spacecraft at the time of departure from Earth, and (3) a scenario with a bounded single impulse at the time of departure from Earth. For the CR3B dynamics, several cislunar applications are considered, including L1 Halo orbit, L2 Halo orbit, and Lunar Gateway 9:2 NRHO. The results indicate that low-thrust spacecraft reachable sets coincide with invariant manifolds existing in multi-body dynamical environments. The proposed method serves as a valuable tool for qualitatively analyzing the evolution of reachable sets under complex dynamics, which would otherwise be either incoherent with existing grid-based reachability approaches or computationally intractable with a complete Hamilton–Jacobi–Bellman method. Full article
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13 pages, 951 KiB  
Article
Human Activity Recognition Algorithm with Physiological and Inertial Signals Fusion: Photoplethysmography, Electrodermal Activity, and Accelerometry
by Justin Gilmore and Mona Nasseri
Sensors 2024, 24(10), 3005; https://doi.org/10.3390/s24103005 (registering DOI) - 9 May 2024
Abstract
Inertial signals are the most widely used signals in human activity recognition (HAR) applications, and extensive research has been performed on developing HAR classifiers using accelerometer and gyroscope data. This study aimed to investigate the potential enhancement of HAR models through the fusion [...] Read more.
Inertial signals are the most widely used signals in human activity recognition (HAR) applications, and extensive research has been performed on developing HAR classifiers using accelerometer and gyroscope data. This study aimed to investigate the potential enhancement of HAR models through the fusion of biological signals with inertial signals. The classification of eight common low-, medium-, and high-intensity activities was assessed using machine learning (ML) algorithms, trained on accelerometer (ACC), blood volume pulse (BVP), and electrodermal activity (EDA) data obtained from a wrist-worn sensor. Two types of ML algorithms were employed: a random forest (RF) trained on features; and a pre-trained deep learning (DL) network (ResNet-18) trained on spectrogram images. Evaluation was conducted on both individual activities and more generalized activity groups, based on similar intensity. Results indicated that RF classifiers outperformed corresponding DL classifiers at both individual and grouped levels. However, the fusion of EDA and BVP signals with ACC data improved DL classifier performance compared to a baseline DL model with ACC-only data. The best performance was achieved by a classifier trained on a combination of ACC, EDA, and BVP images, yielding F1-scores of 69 and 87 for individual and grouped activity classifications, respectively. For DL models trained with additional biological signals, almost all individual activity classifications showed improvement (p-value < 0.05). In grouped activity classifications, DL model performance was enhanced for low- and medium-intensity activities. Exploring the classification of two specific activities, ascending/descending stairs and cycling, revealed significantly improved results using a DL model trained on combined ACC, BVP, and EDA spectrogram images (p-value < 0.05). Full article
(This article belongs to the Section Wearables)
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12 pages, 4945 KiB  
Technical Note
A Signal Matching Method of In-Orbit Calibration of Altimeter in Tracking Mode Based on Transponder
by Qingyu Fang, Wei Guo, Caiyun Wang, Peng Liu, Te Wang, Sijia Han, Shijie Yang, Yufei Zhang, Hailong Peng, Chaofei Ma and Bo Mu
Remote Sens. 2024, 16(10), 1682; https://doi.org/10.3390/rs16101682 (registering DOI) - 9 May 2024
Abstract
In this paper, a matching method for altimeter and transponder signals in Sub-optimal Maximum Likelihood Estimate (SMLE) tracking mode is proposed. In the in-orbit calibration of the altimeter in SMLE tracking mode using the reconstructive transponder, it is necessary to separate the forwarding [...] Read more.
In this paper, a matching method for altimeter and transponder signals in Sub-optimal Maximum Likelihood Estimate (SMLE) tracking mode is proposed. In the in-orbit calibration of the altimeter in SMLE tracking mode using the reconstructive transponder, it is necessary to separate the forwarding signal from the ground echo signal. At the same time, the fluctuations in the received signal of the altimeter, which are caused by the forwarding signal of the transponder, can be eliminated. The transponder generates a bias when measuring the arrival time of the transmitting signal from the altimeter and embeds this bias in both the transponder-recorded data and the altimeter-recorded data. Therefore, the two sets of data have one-to-one correspondence, and they are superimposed using the sliding sum method. Moreover, the distance between the altimeter and the transponder is a parabolic geometric relationship, and the outliers are eliminated by the fitting error minimization decision, and the transponder signal is separated from the ground echo. The final altimeter transmitting–receiving signal path is obtained. Furthermore, the principles underlying this method can be used for any transponder that can adjust the response signal delay during calibration. Full article
(This article belongs to the Topic Radar Signal and Data Processing with Applications)
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20 pages, 21419 KiB  
Article
A New Approach to Detect Hand-Drawn Dashed Lines in Engineering Sketches
by Raquel Plumed, Manuel Contero, Ferran Naya and Pedro Company
Appl. Sci. 2024, 14(10), 4023; https://doi.org/10.3390/app14104023 (registering DOI) - 9 May 2024
Abstract
Sketched drawings sometimes include non-solid lines drawn as sets of consecutive strokes. They represent dashed lines, which are useful for various purposes. Recognizing such dashed lines while parsing drawings is reasonably straightforward if they are outlined with a ruler and compass but becomes [...] Read more.
Sketched drawings sometimes include non-solid lines drawn as sets of consecutive strokes. They represent dashed lines, which are useful for various purposes. Recognizing such dashed lines while parsing drawings is reasonably straightforward if they are outlined with a ruler and compass but becomes challenging when they are hand-drawn. The problem is manageable if the strokes are drawn consecutively so we can leverage the entire sequence. However, it becomes more challenging if they are drawn unordered, and/or we do not have access to the sequence (like in batch vectorization). In this paper, we describe a new approach to identify groups of strokes as depicting single hand-drawn dashed lines. The approach does not use sequence information and is tolerant with irregularities and imprecisions of the strokes. Our goal is to identify hidden lines of sketched engineering line-drawings, which would enable the interpretation of line-drawings with hidden edges, which currently cannot be efficiently vectorized. We speculate that other fields like hand-drawn graph interpretation may also benefit from our approach. Full article
(This article belongs to the Section Computing and Artificial Intelligence)
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20 pages, 7536 KiB  
Article
Fault-Tolerant Multiport Converter for Hybrid Distribution Systems: Configuration, Control Principles and Fault Analysis
by Simone Negri, Giovanni Ubezio and Roberto Sebastiano Faranda
Appl. Sci. 2024, 14(10), 4024; https://doi.org/10.3390/app14104024 (registering DOI) - 9 May 2024
Abstract
Multiport converters (MCs) are widely adopted in many applications, from renewable energy sources and storage integration to automotive applications and distribution systems. They are used in order to interface different energy sources, storage devices and loads with one single, simple converter topology in [...] Read more.
Multiport converters (MCs) are widely adopted in many applications, from renewable energy sources and storage integration to automotive applications and distribution systems. They are used in order to interface different energy sources, storage devices and loads with one single, simple converter topology in contrast to the traditional approach, which can require different solutions made by two-port converters. MCs allow for a reduction in the number of components and cascaded conversion stages with respect to an equivalent system of two-port converters, resulting in reduced complexity, dimensions and costs, as well as in improved reliability and enhanced efficiency. Nevertheless, some aspects related to the design of MCs are still worth further discussion when MCs are applied to hybrid AC/DC distribution systems. First, most converters are developed for one specific application and are not modular in structure. Furthermore, many of the proposed solutions are not equally suitable for AC and DC applications and they can introduce significant issues in hybrid distribution systems, with earthing management being particularly critical. Even though most available solutions offer satisfying steady-state and dynamic performances, fault behavior is often not considered and the possibility of maintaining controllability during faults is overlooked. Building on these three aspects, in this paper, a new MC for hybrid distribution systems is presented. An innovative circuit topology integrating three-phase AC ports and three-wire DC ports and characterized by a unique connection between the AC neutral wire and the DC midpoint neutral wire is presented. Its control principles and properties during external faults are highlighted, and extensive numerical simulations support the presented discussion. Full article
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25 pages, 3567 KiB  
Article
Harnessing Deep Learning and Reinforcement Learning Synergy as a Form of Strategic Energy Optimization in Architectural Design: A Case Study in Famagusta, North Cyprus
by Hirou Karimi, Mohammad Anvar Adibhesami, Siamak Hoseinzadeh, Ali Salehi, Daniele Groppi and Davide Astiaso Garcia
Buildings 2024, 14(5), 1342; https://doi.org/10.3390/buildings14051342 (registering DOI) - 9 May 2024
Abstract
This study introduces a novel framework that leverages artificial intelligence (AI), specifically deep learning and reinforcement learning, to enhance energy efficiency in architectural design. The goal is to identify architectural arrangements that maximize energy efficiency. The complexity of these models is acknowledged, and [...] Read more.
This study introduces a novel framework that leverages artificial intelligence (AI), specifically deep learning and reinforcement learning, to enhance energy efficiency in architectural design. The goal is to identify architectural arrangements that maximize energy efficiency. The complexity of these models is acknowledged, and an in-depth analysis of model selection, their inherent complexity, and the hyperparameters that govern their operation is conducted. This study validates the scalability of these models by comparing them with traditional optimization techniques like genetic algorithms and simulated annealing. The proposed system exhibits superior scalability, adaptability, and computational efficiency. This research study also explores the ethical and societal implications of integrating AI with architectural design, including potential impacts on human creativity, public welfare, and personal privacy. This study acknowledges it is in its preliminary stage and identifies its potential limitations, setting the stage for future research to enhance and expand the effectiveness of the proposed methodology. The findings indicate that the model can steer the architectural field towards sustainability, with a demonstrated reduction in energy usage of up to 20%. This study also conducts a thorough analysis of the ethical implications of AI in architecture, emphasizing the balance between technological advancement and human creativity. In summary, this research study presents a groundbreaking approach to energy-efficient architectural design using AI, with promising results and wide-ranging applicability. It also thoughtfully addresses the ethical considerations and potential societal impacts of this technological integration. Full article
(This article belongs to the Special Issue Sustainable and Smart Energy Systems in the Built Environment)
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