The aim of this research was to optimize the production process of fermented gluten-free quinoa bread. To this end, the effect of different hydrocolloids on the technological, fermentative, and nutritional properties of quinoa-based gluten-free doughs and breads was evaluated. For this purpose, 3% of four different hydrocolloids (sodium alginate, k-carrageenan, xanthan gum, and hydroxypropyl methylcellulose (HPMC)) were used in gluten-free doughs composed of 50% quinoa flour, 20% rice flour, and 30% potato starch. The rheological and fermentative properties of the doughs were evaluated, as well as the chemical composition, specific volume, crust and crumb color, and alveolar structure profile of gluten-free breads. The results highlighted the differences in dough rheology during mixing and fermentation of the doughs. In particular, HPMC showed a good gas retention (93%) during the fermentation of quinoa dough by registering the highest maximum dough development height (Hm). The gluten-free quinoa breads obtained were characterized by significantly different quality parameters (p < 0.05). The use of 3% HPMC resulted in breads with the lowest baking loss, the highest volume, and the most open crumb structure. Full article

Background: The majority of research on the relationship between anorexia nervosa (AN) and trauma has been cross-sectional and quantitative. This study aimed to qualitatively explore how this relationship may shift over time. Methods: A community sample of nine women with a lived experience of AN and trauma were interviewed three times over ten years (1997–2007). Thematic analysis and narrative emplotment were utilised to construct themes both within and across interview transcripts. Results: AN was found to function as a way of coping with trauma (Theme 1), and also became a traumatic experience in and of itself (Theme 2). Longitudinal shifts were identified where the women moved away from AN as a way of coping to loosen the stronghold it had over their lives. Conclusions: This study illuminated how the women’s relationship with AN shifted over time, including the functions and meanings ascribed to AN, and the resilience of women to exit critical stages of AN and achieve meaningful change in their lives over the long term. A further novel finding was that the coping function AN served in early years of life shifted over time as they navigated additional traumas in adulthood and new and diverse ways of coping. Full article

Medulloblastoma is the most common malignant brain tumor in childhood. Initial treatment generally includes surgery, irradiation, and chemotherapy. Approximately 20–30% of patients will experience a recurrence, which portends a very poor prognosis. The current standard of care for evaluation for relapse includes radiographic surveillance with magnetic resonance imaging at regular intervals. The presence of circulating tumor DNA in the cerebrospinal fluid has been demonstrated to be a predictor of a higher risk of progression in a research setting for patients with medulloblastoma treated on a prospective single institution clinical trial. We have previously published and clinically validated a liquid-biopsy-based genetic assay utilizing low-pass whole genome sequencing to detect copy number alterations in circulating tumor DNA. Here, we present two teenage patients with posterior fossa medulloblastoma with recurrent disease who have been monitored with serial liquid biopsies showing tumor evolution over time, demonstrating the clinical utility of these approaches. Full article

The Taurus Mountains in the Mediterranean Coastal Basin, considered a biodiversity hotspot, have a rich biodiversity in the Western Palearctic. The number of marble quarries in the Taurus Mountains has dramatically expanded over the past ten years. The objectives of this study are to (i) determine the impacts of quarrying on wildlife and (ii) determine the potential impacts of quarrying on the future of Taurus. A total of 57,547 photos and video images were analyzed on 5447 photo-trap days in two areas, the marble quarries and the control areas. Using 97 randomly selected marble quarries, the area they cover and their annual growth rates were determined. The most commonly seen animals were the wolf (Canis lupus), fox (Vulpes vulpes), lynx (Lynx lynx), and wild boar (Sus scrofa) in the control area, and the jackal (Canis aureus) and hare (Lepus europaeus) in the marble quarries (p < 0.001). Additionally, we found a significant positive correlation between the distance from the geographical center of the marble quarries and the number of dates of wolf, fox and wild boar sightings, with a significant negative correlation for hares (p < 0.05). A positive correlation was found between the area of marble quarries and the duration of operation (R = 0.89, p < 0.00). The waste from quarries, which makes up 79.7% of the total land used for this purpose, is the greatest cause of habitat degradation. According to calculations, even if no new marble quarries are built as of right now, 7.14% of the Taurus Mountains may have disappeared by the year 2027, and by the year 2032, 8.25% of the Taurus ecosystems may have disappeared completely. The Taurus Mountains, a center of Western Palearctic biodiversity, are being threatened by marble quarries. This study advances our knowledge of how marble quarries may affect wildlife. New strategies must be developed as soon as possible to protect the Taurus Mountains, the hotspot of the Mediterranean basin. Full article

The application of ecological techniques by farmers is important for ensuring the environmentally sustainable advancement of the grain sector. Based on micro-level survey data from 921 Chinese wheat growers in the Hebei and Henan provinces, this study employed an endogenous switching probit model and counterfactual analysis to investigate the impact and mechanisms of digital information utilization on ecological production technology adoption. The results indicated that 43.87% of sample wheat farmers had a low level of adoption of ecological techniques. The utilization of digital information significantly promoted farmers’ adoption. If farmers who currently used digital information were to opt-out, the probability of their high adoption would decrease by 11.26%. The utilization of digital information significantly enhanced the adoption of ecological technologies through three mediating factors: technological cognition, production monitoring, and market channels. Therefore, it is imperative to encourage farmers to broaden their social networks and enhance their perception of the importance of digital information. Additionally, it is essential to promote the industrialization and scale operation of wheat production, direct policy subsidies towards new types of management entities, and ensure the accuracy of the supply of digital information for green production through multiple channels. Therefore, it is imperative to expand farmers’ social networks and leverage rural communities to increase their perceived importance of digital information. Governments should increase subsidies and promote the scale and industrialization of wheat production. Moreover, the accuracy of digital information supply for sustainable production should be promoted through digital learning platforms, production monitoring systems, and e-commerce networks. Full article

Conducting precise evaluations and predictions of the environmental conditions for plant growth in green spaces is crucial for ensuring their health and sustainability. Yet, assessing the health of urban greenery and the plant growth environment represents a significant and complex challenge within the fields of urban planning and environmental management. This complexity arises from two main challenges: the limitations in acquiring high-density, high-precision data, and the difficulties traditional methods face in capturing and modeling the complex nonlinear relationships between environmental factors and plant growth. In light of the superior spatial interpolation capabilities of CEDGAN (conditional encoder–decoder generative adversarial neural network), notwithstanding its comparative lack of robustness across different subjects, and the excellent ability of FCNN (fully connected neural network) to fit multiple nonlinear equation models, we have developed two models based on these network structures. One model performs high-precision spatial attribute interpolation for urban green spaces, and the other predicts and evaluates the environmental conditions for plant growth within these areas. Our research has demonstrated that, following training with various samples, the CEDGAN network exhibits satisfactory performance in interpolating soil pH values, with an average pixel error below 0.03. This accuracy in predicting both spatial distribution and feature aspects improves with the increase in sample size and the number of controlled sampling points, offering an advanced method for high-precision spatial attribute interpolation in the planning and routine management of urban green spaces. Similarly, FCNN has shown commendable performance in predicting and evaluating plant growth environments, with prediction errors generally less than 0.1. Comparing different network structures, models with fewer hidden layers and nodes yielded superior training outcomes. Full article

Despite advancements in algorithms concerning the management of cardiogenic shock, current guidelines still lack the adequate integration of mechanical circulatory support devices. In recent years, more and more devices have been developed to provide circulatory with or without respiratory support, when conservative treatment with inotropic agents and vasopressors has failed. Mechanical circulatory support can be contemplated for patients with severe, refractory, or acute-coronary-syndrome-related cardiogenic shock. Through this narrative review, we delve into the differences among the types of currently used devices by presenting their notable advantages and inconveniences. We address the technical issues emerging while choosing the best possible device, temporarily as a bridge to another treatment plan or as a destination therapy, in the optimal timing for each type of patient. We also highlight the diverse implantation and removal techniques to avoid major complications such as bleeding and limb ischemia. Ultimately, we hope to shed some light in the gaps of evidence and the importance of conducting further organized studies around the topic of mechanical circulatory support when dealing with such a high mortality rate. Full article

Wireless Sensor Networks (WSNs) are crucial in various fields including Health Care Monitoring, Battlefield Surveillance, and Smart Agriculture. However, WSNs are susceptible to malicious attacks due to the massive quantity of sensors within them. Hence, there is a demand for a trust evaluation framework within WSNs to function as a secure system, to identify and isolate malicious or faulty sensor nodes. This information can be leveraged by neighboring nodes, to prevent collaboration in tasks like data aggregation and forwarding. While numerous trust frameworks have been suggested in the literature to assess trust scores and examine the reliability of sensors through direct and indirect communications, implementing these trust evaluation criteria is challenging due to the intricate nature of the trust evaluation process and the limited availability of datasets. This research conducts a novel comparative analysis of three trust management models: “Lightweight Trust Management based on Bayesian and Entropy (LTMBE)”, “Beta-based Trust and Reputation Evaluation System (BTRES)”, and “Lightweight and Dependable Trust System (LDTS)”. To assess the practicality of these trust management models, we compare and examine their performance in multiple scenarios. Additionally, we assess and compare how well the trust management approaches perform in response to two significant cyber-attacks. Based on the experimental comparative analysis, it can be inferred that the LTMBE model is optimal for WSN applications emphasizing high energy efficiency, while the BTRES model is most suitable for WSN applications prioritizing critical security measures. The conducted empirical comparative analysis can act as a benchmark for upcoming research on trust evaluation frameworks for WSNs. Full article

Ernst Faber’s 34 years of literary missionary works reveal his commitment to refining his approach to indigenizing Christianity in China. Employing three linguistic and cultural adaptation strategies—translation and commentary of the Bible, examination and analysis of missionary practical outcomes in Western society, and the revision and reinterpretation of Chinese classics incorporating Christian insights—Faber adapted his methods gradually into China’s specific conditions, indicating a prolonged path of indigenization. Despite expressing appreciation for Chinese culture, a critical examination reveals the preservation of his cultural biases and an unwavering commitment to Christianity as a means of purifying and enriching the spirit of the Chinese people. Rooted in the political context of his time and confidence in European historical world missions, Faber’s indigenization strategy in his Chinese literary works represents an interplay of cultural adaptation and resistance. Full article

Introduction: Patients with cystic fibrosis (CF) commonly experience pulmonary exacerbations, and it is recommended by the TOPIC study to treat this with tobramycin at a dose of 10 mg/kg once daily. The aim of this study was to evaluate the target attainment of the current dosing regimen. Methods: A single-center retrospective cohort study of child and adult patients with CF who received tobramycin between 2019 and 2022 was conducted. Descriptive statistics and linear mixed models were used to assess target attainment for tobramycin. Results: In total, 25 patients (53 courses), of which 10 were children (12 courses) and 15 were adults (41 courses), were included. Those 25 patients all received 10 mg/kg/day. The tobramycin peak concentrations were supratherapeutic in 82.9% and therapeutic in 100.0% of adults and children, respectively. The trough concentrations were outside the target range in 0% and 5.1% of children and adults, respectively. We found lower tobramycin concentrations with the same dose in children compared to adults. Conclusions: This study illustrates the need to validate dosing advice in a real-world setting, as both sub- and supratherapeutic concentrations of tobramycin were prevalent in adults with CF. Full article

The rapid urbanization process means that even moderate-sized cities can quickly become part of larger urban agglomerations, creating new urban zones. Urban Green Infrastructure (UGI) plays a crucial role in these clusters, acting as precious green spaces essential for maintaining ecological safety. This study combines fluctuation analysis based on Morphological Spatial Pattern with traditional landscape pattern analysis, comprehensively addressing the evolution of UGI in terms of quantity, characteristics, and morphology. We selected the Taiyuan-Jinzhong agglomeration as our study area, which is currently in an agglomeration process. The results demonstrated the critical role of surrounding mountains as natural ecological barrier zones. During urban agglomeration, management strategies focused on large-scale afforestation to ensure the quantity of UGI. However, this approach also led to a more clustered landscape with reduced connectivity. Additionally, linear or small-scale UGI types such as branch and islet have seen reductions over the past decade. Changes in internal morphological and complex fluctuations within UGI can harm the formation of ecological networks and potentially negatively affect biodiversity and ecological safety. The research highlights how ecological protection and urban planning policies can influence UGI fluctuations. Therefore, urban managers should not just concentrate on maintaining the quantity of UGI, but also give consideration to changes in its internal features and morphology. Before cities further agglomerate into larger urban clusters, it is crucial to address deficiencies in UGI, continuously improving type configurations and functional structures at the landscape scale. Through strategic planning of UGI, cities can mitigate ecological risks and foster sustainable urban development. Full article

A general methodology for loan amortization under arbitrary discount functions is discussed. It is shown that it is always possible to uniquely define a scheme for constructing the loan amortization schedule with an arbitrary assigned discount function. It is also shown that, even if the loan amortization is carried out from the sequence of principal payments and the sequence of accrued interest, the underlying discount function can be uniquely determined at the maturities corresponding to the installment payment dates. As a special case of the proposed approach, we derive the amortization method according to the law of simple interest. Full article

Protein–protein and protein–mineral interactions can result in defects, such as sedimentation and age gelation, during the storage of high-protein beverages. It is well known that age gelation can be delayed by adding cyclic polyphosphates such as sodium hexametaphosphate (SHMP). This study aims to assess the influence of different phosphate chain lengths of SHMP on the physicochemical properties of high-protein dispersions. The effect of adding different SHMP concentrations at 0%, 0.15%, and 0.25% (w/w) before and after heating of 6%, 8%, and 10% (w/w) milk protein concentrate dispersions was studied. The phosphate chain lengths of SHMPs used in this study were 16.47, 13.31, and 9.88, and they were classified as long-, medium-, and short-chain SHMPs, respectively. Apparent viscosity, particle size, heat coagulation time (HCT), color, and turbidity were evaluated. It was observed that the addition of SHMP (0.15% and 0.25%) increased the apparent viscosity of MPC dispersions. However, the chain length and the concentration of the added SHMP had no significant (p > 0.05) effect on the apparent viscosity after heating the dispersions. The HCT of a dispersion containing 6%, 8%, and 10% protein with no SHMP added was 15.28, 15.61, and 11.35 min, respectively. The addition of SHMP at both levels (0.15% and 0.25%) significantly increased the HCT. Protein dispersions (6%, 8%, and 10%) containing 0.25% short-chain SHMP had the highest HCT at 19.29, 19.61, and 16.09 min, respectively. Therefore, the chain length and concentration of added SHMP significantly affected the HCT of unheated protein dispersion (p < 0.05). Full article

Since the second half of the 20th century, missiology has continued to elevate Missio Dei to a topic of the highest importance in theology. According to Missio Dei, the salvific mission is more theocentric than anthropocentric in that its actuality is wholly rooted in the nature of God. However, much work remains to be conducted to evaluate and reconcile the modern interpretation of the Missio Dei and its predecessor theological doctrines, to avoid illogicalities. Consequently, the responsibility to identify any discrepancies in the systematic knowledge of the Missio Dei falls on the broad shoulders of theology in general, but of missiology in particular. In keeping with this unavoidable intellectual duty, this article interrogates the literature on modern theodicies to improve the conceptualization of the Missio Dei and missionary God in the context of evil and human suffering. The inter-comparative analysis of the biblical Job serves to relate divine perfection and human suffering within process theodicy. Consequently, the intellectual enterprise of this work, with all its shortcomings, not only illuminates another facet of Missio Dei but also motivates further investigation to reconcile mission Dei with the reality of evil, free will, and human suffering. Full article

The scientific literature supports that practicing positive coparenting leads to the healthy development of children. Consequently, professional interest in parenting and coparenting has experienced significant growth, and evaluating coparenting is crucial in family psychology for establishing action protocols in clinical practice. An instrument highly regarded within the scientific community for evaluating coparenting dynamics is The Coparenting Relationship Scale (CRS). This research aims to achieve two objectives: first, to adapt the CRS for the Spanish population of both engaged and separated/divorced parents and to ascertain its reliability, validity, and factorial invariance psychometric properties; second, to assess the effectiveness of the total coparenting measure in categorizing sample participants. A cross-sectional non-experimental investigation was conducted to address these objectives. The first objective was answered by conducting an instrumental study, and the second by an exploratory study using classification techniques and a causal-comparative study using multivariate inferential methods. It was concluded that the model comprising 20 items across two factors, Positive Coparenting and Negative Perception of Coparenting, is the simplest and best fit for the Spanish parent sample; it is invariant regarding gender and marital status, and the measures derived from each factor demonstrate reliability and convergent and discriminant validity. The resulting questionnaire for Spanish parents is named CRS-S_Eg-S&D. The Coparental Vitality measure calculated using the total weighted measure of CRS-S_Eg-S&D allows the sample of participants to be divided into three differentiated clusters called Coparental Robustness, Moderate Coparenting, and Coparenting Rickets. Full article

Sepsis, characterized by life-threatening organ dysfunction due to a maladaptive host response to infection, and its more severe form, septic shock, pose significant global health challenges. The incidence of these conditions is increasing, highlighting the need for effective treatment strategies. This review explores the complex pathophysiology of sepsis, emphasizing the role of the endothelium and the therapeutic potential of corticosteroids. The endothelial glycocalyx, critical in maintaining vascular integrity, is compromised in sepsis, leading to increased vascular permeability and organ dysfunction. Corticosteroids have been used for over fifty years to treat severe infections, despite ongoing debate about their efficacy. Their immunosuppressive effects and the risk of exacerbating infections are significant concerns. The rationale for corticosteroid use in sepsis is based on their ability to modulate the immune response, promote cardiovascular stability, and potentially facilitate organ restoration. However, the evidence is mixed, with some studies suggesting benefits in terms of microcirculation and shock reversal, while others report no significant impact on mortality or organ dysfunction. The Surviving Sepsis Campaign provides cautious recommendations for their use. Emerging research highlights the importance of genomic and transcriptomic analyses in identifying patient subgroups that may benefit from corticosteroid therapy, suggesting a move toward personalized medicine in sepsis management. Despite potential benefits, the use of corticosteroids in sepsis requires careful consideration of individual patient risk profiles, and further research is needed to optimize their use and integrate genomic insights into clinical practice. This review underscores the complexity of sepsis treatment and the ongoing need for evidence-based approaches to improve patient outcomes. Full article

This work presents a novel approach for tailoring molecularly imprinted polymers (MIPs) with a preliminary stage of atom transfer radical polymerization (ATRP), for a more precise definition of the imprinted cavity. A well-defined copolymer of acrylamide and N,N′-methylenebisacrylamide (PAAm-co-PMBAm) was synthesized by ATRP and applied to gold electrodes with the template, followed by a crosslinking reaction. The template was removed from the polymer matrix by enzymatic/chemical action. The surface modifications were monitored via electrochemical impedance spectroscopy (EIS), having the MIP polymer as a non-conducting film designed with affinity sites for CA15-3. The resulting biosensor exhibited a linear response to CA15-3 log concentrations from 0.001 to 100 U/mL in PBS or in diluted fetal bovine serum (1000×) in PBS. Compared to the polyacrylamide (PAAm) MIP from conventional free-radical polymerization, the ATRP-based MIP extended the biosensor’s dynamic linear range 10-fold, improving low concentration detection, and enhanced the signal reproducibility across units. The biosensor demonstrated good sensitivity and selectivity. Overall, the work described confirmed that the process of radical polymerization to build an MIP material influences the detection capacity for the target substance and the reproducibility among different biosensor units. Extending this approach to other cancer biomarkers, the methodology presented could open doors to a new generation of MIP-based biosensors for point-of-care disease diagnosis. Full article

Low P-containing wastewaters (LPWs) exhibit huge P recovery potential, considering their larger volume. P recovery via CaP crystallization using apatite as seed is documented as being potentially well suited for LPWs. However, its responsible mechanisms remain a subject for debate. Taking hydroxyapatite (HAP) as the seed of LPWs, this paper conducted HAP adsorption/dissolution experiments, titration experiments, and P recovery experiments to distinguish the primary responsible mechanism. Results showed that it was HAP dissolution, not P adsorption, that occurred when the initial P concentration was no higher than 5 mg/L, ruling out adsorption mechanism of P recovery from LPWs using HAP as the seed. Significant OH⁻ consumption and rapid P recovery occurred simultaneously within the first 60 s in titration experiments, suggesting CaP crystallization should be responsible for P recovery. Moreover, the continuous increase in P recovery efficiency with seed dosages observed in P recovery experiments seemed to follow well the mechanism of pre-nucleation ion clusters (PNCs) aggregation. During PNCs aggregation, P aggregates with Ca²⁺ quickly, generating CaP PNCs; then, CaP PNCs aggregate with seed particles, followed by CaP PNCs fusion, and ultimately transform into fines attached to the seed surface. PNCs’ aggregation mechanism was further supported by a comparison of seed SEM images before and after P recovery, since denser and smaller rod-shaped fines were observed on the seed surface after P recovery. This study suggests that PNCs’ aggregation is the dominant mechanism responsible for the recovery of P from LPWs via CaP crystallization using HAP as the seed. Full article

To further improve the ride comfort of commercial vehicles, a seat ISD (Inerter–Spring–Damper) suspension utilizing a mechatronic inerter is proposed in this paper. Firstly, a five-DOF (degree-of-freedom) commercial vehicle seat ISD model was built. Then, the positive real network constraint conditions of a biquadratic impedance transfer function were determined, and the meta-heuristic intelligent optimization algorithm was used to solve the parameters. According to the solution, the impedance transfer function was obtained and the specific network structure was realized by network synthesis. Lastly, this study compares the vibration isolation performance of the mechatronic ISD suspension of the vehicle seat with that of a passive suspension. In comparison to passive seat suspension, the seat mechatronic ISD suspension reduces seat vibration transmissibility by 16.33% and vertical acceleration by 16.78%. Results indicate that the new suspension system can be an effective improvement in ride comfort. Full article

The rapid growth of Natural Fiber Laminate (NFL) innovation is a direct response to environmental challenges, positioning these materials as superior alternatives to synthetic fiber composites. This paper delved into the outcomes of an extensive experimental study investigating the influence of sisal fiber (SLF), banana fiber (BF), and glass fiber (GF) on the mechanical and microstructural characteristics of concrete. The water absorption curves were established for sisal fiber concrete (SLFC), banana fiber concrete (BFC), and glass fiber concrete (GFC). Furthermore, Scanning Electron Microscope (SEM) observations were conducted to perform microanalysis and failure analysis of the tested specimens. The results revealed significant improvements in the concrete containing fibers compared to its counterpart in fiber-free concrete. For mixtures with a water-to-binder (W/B) ratio of 0.3, the most optimal mix (GF-30-135) showed improvements in compressive strength, flexural strength, and splitting tensile strengths by 4.13%, 8.93%, and 10.10%, respectively. On the other hand, for W/B of 0.4, mix GF-30-135 showed improvements of 5.05%, 8.55%, and 11.60%, respectively. Furthermore, as the fiber content increased, microscopic analyses revealed a weakening of the bond between the fibers and the rest of the matrix, contributing to the deterioration of the mechanical properties. Full article

This work presents the research results on the development of an innovative, hydrometallurgical technology for the production of manganese(II) perrhenate dihydrate from recycled waste. These wastes are scraps of Ni-based superalloys containing Re and scraps of Li–ion batteries containing Mn—specifically, solutions from the leaching of black mass. This work presents the conditions for the production of Mn(ReO₄)₂·2H₂O. Thus, to obtain Mn(ReO₄)₂·2H₂O, manganese(II) oxide was used, precipitated from the solutions obtained after the leaching of black mass from Li–ion batteries scrap and purified from Cu, Fe and Al (pH = 5.2). MnO₂ precipitation was carried out at a temperature < 50 °C for 30 min using a stoichiometric amount of KMnO₄ in the presence of H₂O₂. MnO₂ precipitated in this way was purified using a 20% H₂SO₄ solution and then H₂O. Purified MnO₂ was then added alternately with a 30% H₂O₂ solution to an aqueous HReO₄ solution. The reaction was conducted at room temperature for 30 min to obtain a pH of 6–7. Mn(ReO₄)₂·2H₂O precipitated by evaporating the solution to dryness was purified by recrystallization from H₂O with the addition of H₂O₂ at least twice. Purified Mn(ReO₄)₂·2H₂O was dried at a temperature of 100–110 °C. Using the described procedure, Mn(ReO₄)₂·2H₂O was obtained with a purity of >99.0%. This technology is an example of the green transformation method, taking into account the 6R principles. Full article