Security and privacy concerns pose significant obstacles to the widespread adoption of IoT technology. One potential solution to address these concerns is the implementation of cryptographic protocols on resource-constrained IoT edge nodes. However, the limited resources available on these nodes make it challenging to effectively deploy such protocols. In cryptographic systems, finite-field multiplication plays a pivotal role, with its efficiency directly impacting overall performance. To tackle these challenges, we propose an innovative and compact bit-serial systolic layout specifically designed for Montgomery multiplication in the binary-extended field. This novel multiplier structure boasts regular cell architectures and localized communication connections, making it particularly well suited for VLSI implementation. Through a comprehensive complexity analysis, our suggested design demonstrates significant improvements in both area and area–time complexities when compared to existing competitive bit-serial multiplier structures. This makes it an ideal choice for cryptographic systems operating under strict area utilization constraints, such as resource-constrained IoT nodes and tiny embedded devices. Full article

Leishmaniasis in wild canids is a vector-borne disease caused in Europe by the protozoan parasite Leishmania infantum. To date, there is limited information on clinical signs and laboratory abnormalities in wolves due to leishmaniasis. The current clinical case report described a female Iberian wolf (Canis lupus signatus) housed in semi-captivity conditions at the Centro del Lobo Ibérico “Félix Rodríguez de la Fuente”, in Robledo de Sanabria, Zamora (Spain), with an interdigital ulcerous wound at the right forepaw, hyper-gammaglobulinemia, and abnormal liver blood parameters. Definitive serodiagnosis of leishmaniasis was established using antileishmanial serum antibodies and PCR analysis of different biological samples. A gold-standard anti-L. infantum treatment protocol consisting in subcutaneous meglumine antimoniate and oral allopurinol combination was installed. However, the presence of pain at the site of injection due to meglumine antimoniate administration forced its substitution by oral miltefosine. A progressive reduction of the levels of anti-L. infantum serum antibodies and the concentrations of gamma-globulin fraction was detected after antileishmanial treatment as well as a decline of liver GPT. To our knowledge, this is the first case of leishmaniasis diagnosed in a wolf housed in semi-captivity conditions, with the condition subsequently treated and successfully cured. Full article

Succinic semialdehyde dehydrogenase (SSADH) is a mitochondrial enzyme involved in the catabolism of the neurotransmitter γ-amino butyric acid. Pathogenic variants in the gene encoding this enzyme cause SSADH deficiency, a developmental disease that manifests as hypotonia, autism, and epilepsy. SSADH deficiency patients usually have family-specific gene variants. Here, we describe a family exhibiting four different SSADH variants: Val90Ala, Cys93Phe, and His180Tyr/Asn255Asp (a double variant). We provide a structural and functional characterization of these variants and show that Cys93Phe and Asn255Asp are pathogenic variants that affect the stability of the SSADH protein. Due to the impairment of the cofactor NAD⁺ binding, these variants show a highly reduced enzyme activity. However, Val90Ala and His180Tyr exhibit normal activity and expression. The His180Tyr/Asn255Asp variant exhibits a highly reduced activity as a recombinant species, is inactive, and shows a very low expression in eukaryotic cells. A treatment with substances that support protein folding by either increasing chaperone protein expression or by chemical means did not increase the expression of the pathogenic variants of the SSADH deficiency patient. However, stabilization of the folding of pathogenic SSADH variants by other substances may provide a treatment option for this disease. Full article

This paper addresses the problem of hydrogen generation from hydrocarbon gases using Steam Methane Reforming (SMR) with byproduct CO₂ injected into and stored in a partially depleted oil reservoir. It focuses on the reservoir aspects of the problem using numerical simulation of the processes. To this aim, a numerical model of a real oil reservoir was constructed and calibrated based on its 30-year production history. An algorithm was developed to quantify the CO₂ amount from the SMR process as well as from the produced fluids, and optionally, from external sources. Multiple simulation forecasts were performed for oil and gas production from the reservoir, hydrogen generation, and concomitant injection of the byproduct CO₂ back to the same reservoir. EOR from miscible oil displacement was found to occur in the reservoir. Various scenarios of the forecasts confirmed the effectiveness of the adopted strategy for the same source of hydrocarbons and CO₂ sink. Detailed simulation results are discussed, and both the advantages and drawbacks of the proposed approach for blue hydrogen generation are concluded. In particular, the question of reservoir fluid balance was emphasized, and its consequences were presented. The presented technology, using CO₂ from hydrogen production and other sources to increase oil production, also has a significant impact on the protection of the natural environment via the elimination of CO₂ emission to the atmosphere with concomitant production of H₂. Full article

For a precise analysis of buildings under earthquake effects, the load–deformation behaviour of the bracing walls must be comprehensively known. The horizontal bracing walls are often clamped in the basement; however, less attention has been paid to these walls’ clamping parts in the past. This study presents three shear wall experiments (NW 1, NW 2, NW 3) with heights up to six meters in a scale of 1:1.5 to the real size. Measured were the force–displacement curve, the curvature distribution over the height, the crack pattern, and the crack opening and spacing. Twelve displacement transducers, an optical measurement system with eight cameras, and a manual crack measurement were utilised. Out of the measurements, the impact of the tension shift effect on the load–displacement curves could be quantified for the cantilever part of the walls. Additionally, it was found out that a sliding failure in the clamping part must be considered if the aspect ratio of H/L is equal to or less than one. Full article

Underwater long-endurance platforms are crucial for continuous oceanic observation, allowing for sustained data collection from a multitude of sensors deployed across diverse underwater environments. They extend mission durations, reduce maintenance needs, and significantly improve the efficiency and cost-effectiveness of oceanographic research endeavors. This paper investigates the closed-loop depth control of actuation systems employed in underwater vehicles, focusing on the energy consumption of two different mechanisms: variable buoyancy and propeller actuated devices. Using a prototype previously developed by the authors, this paper presents a detailed model of the vehicle using both actuation solutions. The proposed model, although being a linear-based one, accounts for several nonlinearities that are present such as saturations, sensor quantization, and the actuator brake model. Also, it allows a simple estimation of the energy consumption of both actuation solutions. Based on the developed models, this study then explores the intricate interplay between energy consumption and control accuracy. To this end, several PID-based controllers are developed and tested in simulation. These controllers are used to evaluate the dynamic response and power requirements of variable buoyancy systems and propeller actuated devices under various operational conditions. Our findings contribute to the optimization of closed-loop depth control strategies, offering insights into the trade-offs between energy efficiency and system effectiveness in diverse underwater applications. Full article

Background and Purpose: Distinguishing treatment-induced imaging changes from progressive disease has important implications for avoiding inappropriate discontinuation of a treatment. Our goal in this study is to evaluate the utility of dynamic contrast-enhanced (DCE) perfusion MRI as a biomarker for the early detection of progression. We hypothesize that DCE-MRI may have the potential as an early predictor for the progression of disease in GBM patients when compared to the current standard of conventional MRI. Methods: We identified 26 patients from 2011 to 2023 with newly diagnosed primary glioblastoma by histopathology and gross or subtotal resection of the tumor. Then, we classified them into two groups: patients with progression of disease (POD) confirmed by pathology or change in chemotherapy and patients with stable disease without evidence of progression or need for therapy change. Finally, at least three DCE-MRI scans were performed prior to POD for the progression cohort, and three consecutive DCE-MRI scans were performed for those with stable disease. The volume of interest (VOI) was delineated by a neuroradiologist to measure the maximum values for Ktrans and plasma volume (Vp). A Friedman test was conducted to evaluate the statistical significance of the parameter changes between scans. Results: The mean interval between subsequent scans was 57.94 days, with POD-1 representing the first scan prior to POD and POD-3 representing the third scan. The normalized maximum Vp values for POD-3, POD-2, and POD-1 are 1.40, 1.86, and 3.24, respectively (FS = 18.00, p = 0.0001). It demonstrates that Vp max values are progressively increasing in the three scans prior to POD when measured by routine MRI scans. The normalized maximum Ktrans values for POD-1, POD-2, and POD-3 are 0.51, 0.09, and 0.51, respectively (FS = 1.13, p < 0.57). Conclusions: Our analysis of the longitudinal scans leading up to POD significantly correlated with increasing plasma volume (Vp). A longitudinal study for tumor perfusion change demonstrated that DCE perfusion could be utilized as an early predictor of tumor progression. Full article

Companion animal obesity has emerged as a significant veterinary health concern globally, with escalating rates posing challenges for preventive and therapeutic interventions. Obesity not only leads to immediate health problems but also contributes to various comorbidities affecting animal well-being and longevity, with consequent emotional and financial burdens on owners. While past treatment strategies have shown limited success, recent breakthroughs in human medicine present new opportunities for addressing this complex issue in companion animals. Here, we discuss the potential of GLP-1 receptor agonists, specifically semaglutide and tirzepatide, already approved for human use, for addressing companion animal obesity. These drugs, originally developed to treat type 2 diabetes in humans and subsequently repurposed to treat obesity, have demonstrated remarkable weight loss effects in rodents, non-human primates and people. Additionally, newer drug combinations have shown even more promising results in clinical trials. Despite current cost and supply challenges, advancements in oral and/or extended-release formulations and increased production may make these drugs more accessible for veterinary use. Thus, these drugs may have utility in companion animal weight management, and future feasibility studies exploring their efficacy and safety in treating companion animal obesity are warranted. Full article

Adult patients suffering from Crohn’s disease (CD) are often dissatisfied with the information they receive from their physicians about nutrition and its impact on CD inflammation activity. Only a few publications are available about patients’ internet research on nutrition in CD. The study aim is to elucidate the internet information sources of adult CD patients regarding nutritional advice via a questionnaire. Methods: A questionnaire with 28 (general and specific) questions for outpatients at our tertiary center with CD was created and used for an analysis of their information sources about nutrition in CD. Four CD and/or nutritional medicine experts examined the 21 most relevant websites referring to nutritional advice for CD patients. Results: One hundred and fifty CD patients reported their Internet research behavior for nutritional advice and their dietary habits. Many CD patients prefer to consult the Internet instead of asking their general practitioner (GP) for nutritional recommendations. Most of the websites providing nutritional advice for CD patients are of very poor quality and cannot be recommended. We found significant correlations between (a) nutritional habits of CD patients, (b) their information sources and several demographic or CD-related factors. There is a lack of websites which provide high-quality, good nutritional advice to CD patients. Conclusion: The majority of the examined websites did not provide sufficient information according to the CD guidelines and nutritional medicine guidelines. A higher quality level of website content (e.g., on social media or on university/center websites) provided by experienced physicians is required to secure trustworthy and reliable nutritional information in CD. Full article

This study investigates the environmental and occupational health risks associated with arsenic (As) and mercury (Hg) contamination in a specific industrial site: a mercury mine site that contains a metallurgical plant within its premises. Utilising a comprehensive sampling and analysis approach, As and Hg concentrations in the soil and air across various zones within the site were assessed. The results revealed elevated levels of both contaminants, particularly in areas proximal to industrial processes such as metal smelting and waste disposal. Risk assessment using the Cancer Risk (CR) and Hazard Index (HI) indices demonstrated significant health hazards that exceed regulatory thresholds, indicating potential carcinogenic effects from As exposure and risks of non-cancerous occupational diseases. Three distinct risk areas were identified based on the CR and HI indices, guiding the formulation of tailored risk management strategies. While some zones may permit limited industrial activities under specific conditions, others require stringent safety measures and specialised personal protective equipment (PPE) due to exceptionally high contaminant concentrations. Overall, the findings underscore the critical need for robust safety protocols and regulatory compliance to mitigate the health risks associated with As and Hg exposure in industrial settings, ensuring the protection of worker health, environmental stewardship, and the promotion of sustainable mining practices. Full article

This paper investigates remote sensing data recognition and classification with multimodal data fusion. Aiming at the problems of low recognition and classification accuracy and the difficulty in integrating multimodal features in existing methods, a multimodal remote sensing data recognition and classification model based on a heatmap and Hirschfeld–Gebelein–Rényi (HGR) correlation pooling fusion operation is proposed. A novel HGR correlation pooling fusion algorithm is developed by combining a feature fusion method and an HGR maximum correlation algorithm. This method enables the restoration of the original signal without changing the value of transmitted information by performing reverse operations on the sample data. This enhances feature learning for images and improves performance in specific tasks of interpretation by efficiently using multi-modal information with varying degrees of relevance. Ship recognition experiments conducted on the QXS-SROPT dataset demonstrate that the proposed method surpasses existing remote sensing data recognition methods. Furthermore, land cover classification experiments conducted on the Houston 2013 and MUUFL datasets confirm the generalizability of the proposed method. The experimental results fully validate the effectiveness and significant superiority of the proposed method in the recognition and classification of multimodal remote sensing data. Full article

This study employs the discrete element method to investigate the influence of particle size on the load-bearing characteristics of aggregates, with a specific emphasis on the aggregates used in escape ramp arrester beds. This study utilises the log edge detection algorithm to introduce an innovative approach for modelling irregularly shaped pebbles, integrating their physical properties into a comprehensive discrete element model to enhance the accuracy and applicability of simulations involving such pebbles. Meticulous validation and parameter calibration (friction coefficient: 0.37, maximum RMSE: 3.43) confirm the accuracy of the simulations and facilitate an in-depth examination of the mechanical interactions between aggregate particles at macroscopic and microscopic scales. The findings reveal a significant relationship between the particle size and load-bearing capacity of aggregates. Smaller pebbles, which are more flexible under pressure, can be packed more densely, thereby improving the distribution of vertical forces and increasing the concentration of local stress. This enhancement substantially increases the overall load-bearing capacity of aggregates. These discoveries hold significant implications for engineering practices, particularly in the optimisation of safety for truck escape ramps and in identifying the ideal sizes of pebbles with irregular shapes. Full article

The purpose of these studies was to establish the influence of the microstructural and rheological characteristics of modified bitumen compositions on the strength indicators of asphalt concrete. The effect of additives concentration on the rheological characteristics and microstructure of binary “bitumen–surfactant”, “bitumen-AG-4I”, and ternary “bitumen-AG-4I-AG-4I” systems has been studied. To assess the effect of bitumen dispersion on the physical and mechanical characteristics of modified asphalt concrete samples, the compressive strength value was determined. The following chemicals have been used as additives: the original product AS-1, industrial additive AMDOR-10, and used sealant AG-4I, a product based on polyisobutylene and petroleum oils. At an increased content of AG-4I (C ≥ 1.0 g/dm³) in ternary systems, the contribution of the emerging intermolecular polyisobutylene network to the development of structuring processes increases while the viscous effect of the surfactant AS-1 decreases. It has been established that the minimum size of bee-like bitumen structures (1.66 µm) is recorded with the joint presence of additives in the bitumen, AS-1 at a level of 1.0 g/dm³ and AG-4I at a level of 1.0 g/dm³. Under the same concentration regimes of the ternary bitumen composition, the maximum increase in compressive strength R_D was achieved with the smallest size of bee-like structures of modified bitumen. Full article

To improve the workshop production efficiency of textile enterprises and balance the total operating time of all machines in each operation, this paper proposes a modified algorithm based on the combination of the ant colony optimization (ACO) algorithm and production products, which we call the product ant colony optimization (PACO) algorithm. The local pheromone update rule in the ACO algorithm is modified through the close relationship between textile machinery and production products in the textile workshop; the pheromone is then introduced into production products based on the constraints of the textile machine. A heuristic function is designed to improve the utilization rate of textile machines to increase the heuristic value of machines that are less frequently used in the algorithm iteration process. In addition, this paper combines the convergence speed and the global search ability of the algorithm with a designed variable pheromone evaporate parameter. The comparison among the initially designed PACO algorithm, the separately modified PACO algorithm, and the integratively modified PACO algorithm demonstrates that the proposed enhancement effectively addresses scheduling issues in textile flexible workshops and various workshops with similar constraint conditions. Full article

Currently, metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) are considered to be the main causes of fibrosis. In turn, fibrosis may lead to the development of hepatocellular carcinoma or advanced cirrhosis, i.e., potentially life-threatening conditions. It is likely that therapy aimed at reducing the risk of developing hepatic steatosis and inflammation could be helpful in minimizing the threat/probability of organ fibrosis. In recent years, increasing attention has been paid to the influence of nutraceuticals in the prevention and treatment of liver diseases. Therefore, the aim of this review was to describe the precise role of selected ingredients such as vitamin C, beta-carotene, omega-3 fatty acids, and curcumin. It is likely that the use of these ingredients in the treatment of patients with MASLD/MASH, along with behavioral and pharmacological therapy, may have a beneficial effect on combating inflammation, reducing oxidative stress, and thereby preventing liver damage. Full article

The metaverse, which amalgamates physical and virtual realms for diverse social activities, has been the focus of extensive application development by organizations, research institutes, and companies. However, these applications are often isolated, employing distinct authentication methods across platforms. Achieving interoperable authentication is crucial for when avatars traverse different metaverses to mitigate security concerns like impersonation, mutual authentication, replay, and server spoofing. To address these issues, we propose a blockchain-enabled secure and interoperable authentication scheme. This mechanism uniquely identifies users in the physical world as well as avatars, facilitating seamless navigation across verses. Our proposal is substantiated through informal security analyses, employing automated verification of internet security protocols and applications (AVISPA), the real-or-random (ROR) model, and Burrows–Abadi–Needham (BAN) logic and showcasing effectiveness against a broad spectrum of security threats. Comparative assessments against similar schemes demonstrate our solution’s superiority in terms of communication costs, computation costs, and security features. Consequently, our blockchain-enabled, interoperable, and secure authentication scheme stands as a robust solution for ensuring security in metaverse environments. Full article

The verification of image integrity has attracted increasing attention. Irreversible algorithms embed fragile watermarks into cover images to verify their integrity, but they are not reversible due to unrecoverable loss. In this paper, a new dual tampering detection scheme for reversible image fragile watermarking is proposed. The insect matrix reversible embedding algorithm is used to embed the watermark into the cover image. The cover image can be fully recovered when the dual-fragile-watermarked images are not tampered with. This study adopts two recovery schemes and adaptively chooses the most appropriate scheme to recover tampered data according to the square errors between the tampered data and the recovered data of two watermarked images. Tampering coincidence may occur when a large region of the fragile-watermarked image is tampered with, and the recovery information corresponding to the tampered pixels may be missing. The tampering coincidence problem is solved using image-rendering techniques. The experimental results show that the PSNR value of the watermarked image obtained using our scheme can reach 46.37 dB, and the SSIM value is 0.9942. In addition, high-accuracy tampering detection is achieved. Full article

The two existing clades of Galloanseres, orders Galliformes (landfowl) and Anseriformes (waterfowl), exhibit dramatically different evolutionary trends. Mitochondria serve as primary sites for energy production in organisms, and numerous studies have revealed their role in biological evolution and ecological adaptation. We assembled the complete mitogenome sequences of two species of the genus Aythya within Anseriformes: Aythya baeri and Aythya marila. A phylogenetic tree was constructed for 142 species within Galloanseres, and their divergence times were inferred. The divergence between Galliformes and Anseriformes occurred ~79.62 million years ago (Mya), followed by rapid evolution and diversification after the Middle Miocene (~13.82 Mya). The analysis of selective pressure indicated that the mitochondrial protein-coding genes (PCGs) of Galloanseres species have predominantly undergone purifying selection. The free-ratio model revealed that the evolutionary rates of COX1 and COX3 were lower than those of the other PCGs, whereas ND2 and ND6 had faster evolutionary rates. The CmC model also indicated that most PCGs in Anseriformes exhibited stronger selective constraints. Our study suggests that the distinct evolutionary trends and energy requirements of Galliformes and Anseriformes drive different evolutionary patterns in the mitogenome. Full article

The purpose of this review is to focus on the diagnostic endoscopic ultrasound of the gastrointestinal tract. In the last decades, EUS has gained a central role in the staging of epithelial and sub-epithelial lesions of the gastrointestinal tract. With the evolution of imaging, the position of EUS in the diagnostic work-up and the staging flow-chart has continuously changed with two extreme positions: some gastroenterologists think that EUS is absolutely indispensable, and some think it is utterly useless. The truth is, as always, somewhere in between the two extremes. Analyzing the most up-to-date and strong evidence, we will try to give EUS the correct position in our daily practice. Full article

Due to the extraordinary mechanical properties of ultra-high-performance concrete (UHPC), the shear stirrups in UHPC beams could potentially be eliminated. This study aimed to determine the effect of beam height and steel fiber volume content on the shear behavior of non-stirrup UHPC beams under a larger shear span–depth ratio (up to 2.8). Eight beams were designed and fabricated including six non-stirrup UHPC beams and two comparing stirrup-reinforced normal concrete (NC) beams. The experimental results demonstrated that the steel fiber volume content could be a crucial factor affecting the ductility, cracking strength, and shear capacity of non-stirrup UHPC beams and altering their failure modes. Additionally, the height of the beam had a considerable effect on its shear resistance. French standard formulae were more accurate for the UHPC beams with larger shear span–depth ratios, PCI-2021 formulae greatly overestimated the shear capacity of UHPC beams with larger shear span–depth ratios, and Xu’s formulae were more accurate for the steel fiber-reinforced UHPC beams with larger shear span–depth ratios. In summary, French standard formulae were the most suitable formulae for predicting the shear capacity of UHPC beams in this paper. Full article

In response to a perceived epidemic of coronary heart disease, Ancel Keys introduced the lipid–heart hypothesis in 1953 which asserted that high intakes of total fat, saturated fat, and cholesterol lead to atherosclerosis and that consuming less fat and cholesterol, and replacing saturated fat with polyunsaturated fat, would reduce serum cholesterol and consequently the risk of heart disease. Keys proposed an equation that would predict the concentration of serum cholesterol (ΔChol.) from the consumption of saturated fat (ΔS), polyunsaturated fat (ΔP), and cholesterol (ΔZ): ΔChol. = 1.2(2ΔS − ΔP) + 1.5ΔZ. However, the Keys equation conflated natural saturated fat and industrial trans-fat into a single parameter and considered only linoleic acid as the polyunsaturated fat. This ignored the widespread consumption of trans-fat and its effects on serum cholesterol and promoted an imbalance of omega-6 to omega-3 fatty acids in the diet. Numerous observational, epidemiological, interventional, and autopsy studies have failed to validate the Keys equation and the lipid–heart hypothesis. Nevertheless, these have been the cornerstone of national and international dietary guidelines which have focused disproportionately on heart disease and much less so on cancer and metabolic disorders, which have steadily increased since the adoption of this hypothesis. Full article

This research was undertaken to study the duration effects on the seismic economic risk of steel moment frame (SMF) buildings, a prominent class of buildings in commercial stock. Firstly, a modified version of FEMA P-695 ground motion scaling, tailored for seismic loss estimation purposes and incorporating two sets of spectrally matched bi-directional short- and long-duration ground motions, is proposed to study code-compliant plan-symmetrical SMFs with different heights (i.e., two to 20 stories). It is shown that long-duration ground motions increase the collapse risk of SMFs, on average, by 28.0% at the MCE level. Next, a component-based loss estimation methodology was adopted for evaluating the seismic losses under each set of ground motions. These losses are studied separately for building components (i.e., structural and nonstructural) and contents. Moreover, we propose an approach for calculating average annualized loss (AAL) as a prominent risk meter that segregates contributions of short- and long-duration ground motions to attain hazard consistency. Loss analyses showed the minimal impact of building height on the contribution of these two types of earthquakes. The seismic risk analysis of buildings also revealed that collapse risk is influenced mainly by duration effects followed by building and content losses. Full article