The study assesses the direct effects of climate change by 2060, including extreme events, on the productivity of regional crop farming and livestock in Greece, and the broader socio-economic effects on the agri-food and other sectors. Different approaches (i.e., agronomic models, statistical regression models, and equations linking thermal stress to livestock output) were combined to estimate the effects on productivity from changes in the average values of climatic parameters, and subsequently the direct economic effects from this long-term climate change. Recorded damages from extreme events together with climatic thresholds per event and crop were combined to estimate the direct economic effects of these extremes. The broader socio-economic effects were then estimated through input–output analysis. Under average levels of future extreme events, the total direct economic losses for Greek agriculture due to climate change will be significant, from EUR 437 million/year to EUR 1 billion/year. These losses approximately double when indirect effects on other sectors using agricultural products as inputs (e.g., food and beverage, hotels, and restaurants) are considered, and escalate further under a tenfold impact of extreme events. Losses in the GDP and employment are moderate at the national level, but significant in regions where the contribution of agriculture is high. Full article

The licensing of new reactors implies the use of verified and validated neutronic codes. Numerical validation can rely on sensitivity and uncertainty studies, but they require repeated execution of time-consuming neutron flux and depletion calculations. The computational costs can be reduced by using perturbation theories. However, the uncoupled Depletion Perturbation Theory is restricted to single integral values such as nuclide density. Relying on reduced-basis approaches, which reconstruct all nuclide densities at once, is one way to get around this restriction. Furthermore, the adjoint-based reduced-order model uses the direct and adjoint equations for projection. For diffusion or transport calculations, the Exact-to-Precision Generalized Perturbation Theory was developed. Still, no models for depletion calculations are readily available. Therefore, this paper describes a novel adjoint-based reduced-order model for the Bateman Equation. It uses a range-finding algorithm to create the basis and the uncoupled Depletion Perturbation Theory for the reconstruction of the first order replaced by with a first order formulation. Our paper shows that for several perturbed cases, the depletion reduced-order model successfully reconstructs the nuclide densities. As a result, this serves as a proof of concept for our adjoint-based reduced-order model, which can perform sensitivity and uncertainty burn-up analysis in a shorter time. Full article

In this paper, a solar thermochemical reactor is designed based on a 5 kW non-coaxial concentrating solar simulator, and a mathematical model is established for thermal calculations. The calculated temperature distribution is used as a load condition for thermal stress analyses. The model is used to study the influence of the solar simulator power, solar reactor inner wall material’s emissivity, working pressure, gas inlet velocity, and thermocouple opening diameter on the thermal stress of the solar reactor. The results show that thermal stress increases with the increase in solar simulator power and the emissivity of the inner wall material in the solar reactor. The inlet velocity and working pressure have little effect on the thermal stress of the reactor and cannot prevent damage to the reactor. In the case of maintaining the diameter of the thermocouple at the front end of the reactor, increasing the diameter of the thermocouple inside the reactor leads to an increase in thermal stress around the reactor. Meanwhile, using a finer thermocouple can reduce the thermal stress inside the reactor and extend its service life, which will provide a foundation for designing practical industrial applications in the future. Full article

Every year, a significant amount of pepper stalks are wasted due to low utilization. The ash produced from pepper stalks contains a significant amount of alkaline salts, which are food additives that can enhance the quality of noodles. Therefore, utilizing natural pepper straw ash to improve the quality of noodles shows promising development prospects. In this study, pepper straw ash leachate (PSAL) was extracted and added to noodles. The quality of the noodles gradually improved with the addition of PSAL, with the best effect observed at a concentration of 18% (PSAL mass/flour mass). This addition resulted in a 57.8% increase in noodle hardness, a 55.43% increase in chewiness, a 19.41% rise in water absorption rate, and a 13.28% increase in disulfide bond content. These alterations rendered the noodles more resilient during cooking, reducing their tendency to soften and thus enhancing chewiness and palatability. Incorporating PSAL also reduced cooking loss by 57.79%. Free sulfhydryl groups decreased by 5.1%, and scanning electron microscopy revealed a denser gluten network structure in the noodles, with more complete starch wrapping. This study significantly enhanced noodle quality and provided a new pathway for the application of pepper straw resources in the food industry. Full article

Habitat quality is an important basis for human well-being and the achievement of sustainable development. Based on land-use data for the Bosten Lake Basin in 2000, 2005, 2010, 2015, and 2022, the PLUS and InVEST models are applied in this study to predict and analyze land-use changes and explore the spatial and temporal evolution characteristics of the region’s habitat quality. Additionally, we use a geographic detector model to reveal the drivers of spatial variation in habitat quality. The results show that: (1) Land use in Bosten Lake Basin is dominated by grassland and bare land, with an area share of 93.21%. Habitat quality shows a trend of degradation followed by improvement, with a spatial pattern of high in the northwest and low in the southeast. (2) Habitat quality in 2030 increased from 2022 in all cases, with a mean of 0.354 for the natural development scenario, a maximum of 0.355 for the ecological development scenario, and a minimum of 0.353 for the economic development scenario. (3) The main drivers affecting habitat quality in the Bosten Lake watershed are DEM, mean annual precipitation (MAP), and GDP per capita. X1∩X4 (0.50) and X4∩X10 (0.51) are the interaction factors with the largest dominant effect in 2000, 2010 and 2020, respectively. Full article

Heat stress is one of the stressors that negatively affect broiler chickens, leading to a reduction in production efficiency and profitability. This reduction affects the economy in general, especially in hot and semi-hot countries. Therefore, improving heat tolerance of broiler chicks is a key to sustained peak performance, especially under adverse environmental heat stress conditions. The present study investigated three early feed withdrawal regimes (FWD) as a potential mitigation for thermal stress exposure. A total of 240 unsexed one-day-old Cobb-500 chicks were randomly recruited to one of four experimental groups using a completely randomized design (10 birds × 6 replicates). The experimental groups included the control group with no feed withdrawal (control), while the other three groups were subjected to early feed withdrawal for either 24 h on the 5th day of age (FWD-24), 12 h on the 3rd and 5th day of age (FWD-12), or 8 h on the 3rd, 4th, and 5th day of age (FWD-8), respectively. Production performance was monitored throughout the experiment. Meanwhile, blood and liver samples were taken at the end of the experimental period to evaluate major physiological dynamic changes. Our findings demonstrated that under chronic heat stress conditions, FWD treatments significantly improved broilers’ production performance and enhanced several physiological parameters compared with the control. Serum levels of thyroid hormones were elevated, whereas leptin hormone was decreased in FWD groups compared with the control. Moreover, serum total protein, globulin, and hemoglobin levels were higher, while total cholesterol and uric acid were lower in the FWD groups. Furthermore, FWD groups showed significantly higher antioxidant marker activity with a significantly lower lipid peroxidation level. Immunoglobulin levels, lysozyme, complement factor C3, and liver heat shock protein 70 (HSP70) concentration were also elevated in FWD compared with the control. Also, serum interleukin-1β (IL-1β) and interferon-gamma (IFN-γ) significantly increased with FWD. Based on our findings, early feed withdrawal can be applied as a promising non-invasive nutritional strategy for broilers reared under chronic heat stress conditions. Such a strategy promotes the alleviation of the deleterious effects of heat stress on broiler performance, immunity, and redox status, owing to the onset of physiological adaptation and the development of thermotolerance ability. Full article

The effects of submerged plant-induced calcium and phosphorus coprecipitation on the phosphorus cycle in aquatic environments and interspecific differences are still unclear. Herein, we selected Ceratophyllum demersum L. and Potamogeton crispus L. to construct a sediment–water-submerged plant system. We examined how phosphorus concentrations in the water, sediment, and plant ash changed over time with different phosphorus and calcium treatments and explored the effects of photosynthesis-induced calcium and phosphorus coprecipitation on water’s phosphorus cycle and variations between different submerged plant species. The main results were as follows: (1) The phosphorus reduction in the P. crispus system was less than that in the C. demersum system. (2) P. crispus had higher total ash phosphorus (TAP) values than C. demersum. (3) The sediment total phosphorus (STP) and its fractions with P. crispus were most affected by phosphorus concentration while those with C. demersum were most affected by time. Overall, the two submerged species exhibited different calcium and phosphorus coprecipitation levels and had distinct effects on the water-to-phosphorus cycle. When submerged plants are introduced to reduce and stabilize the phosphorus levels, plant interspecific differences in their induced calcium and phosphorus coprecipitation on water and phosphorus cycling must be fully assessed. Full article

The small intestine is important to the digestion and absorption of rumen undegradable nutrients, as well as the barrier functionality and immunological responses in ruminants. Oxidative stress induces a spectrum of pathophysiological symptoms and nutritional deficits, causing various gastrointestinal ailments. Previous studies have shown that nicotinamide (NAM) has antioxidant properties, but the potential mechanism has not been elucidated. The aim of this study was to explore the effects of NAM on hydrogen peroxide (H₂O₂)-induced oxidative injury in bovine intestinal epithelial cells (BIECs) and its potential mechanism. The results showed that NAM increased the cell viability and total antioxidant capacity (T-AOC) and decreased the release of lactate dehydrogenase (LDH) in BIECs challenged by H₂O₂. The NAM exhibited increased expression of catalase, superoxide dismutase 2, and tight junction proteins. The expression of autophagy-related proteins was increased in BIECs challenged by H₂O₂, and NAM significantly decreased the expression of autophagy-related proteins. When an autophagy-specific inhibitor was used, the oxidative injury in BIECs was not alleviated by NAM, and the T-AOC and the release of LDH were not affected. Collectively, these results indicated that NAM could alleviate oxidative injury in BIECs by enhancing antioxidant capacity and increasing the expression of tight junction proteins, and autophagy played a crucial role in the alleviation. Full article

Disease and detection is crucial for the protection of forest growth, reproduction, and biodiversity. Traditional detection methods face challenges such as limited coverage, excessive time and resource consumption, and poor accuracy, diminishing the effectiveness of forest disease prevention and control. By addressing these challenges, this study leverages drone remote sensing data combined with deep object detection models, specifically employing the YOLO-v3 algorithm based on loss function optimization, for the efficient and accurate detection of tree diseases and pests. Utilizing drone-mounted cameras, the study captures insect pest image information in pine forest areas, followed by segmentation, merging, and feature extraction processing. The computing system of airborne embedded devices is designed to ensure detection efficiency and accuracy. The improved YOLO-v3 algorithm combined with the CIoU loss function was used to detect forest pests and diseases. Compared to the traditional IoU loss function, CIoU takes into account the overlap area, the distance between the center of the predicted frame and the actual frame, and the consistency of the aspect ratio. The experimental results demonstrate the proposed model’s capability to process pest and disease images at a slightly faster speed, with an average processing time of less than 0.5 s per image, while achieving an accuracy surpassing 95%. The model’s effectiveness in identifying tree pests and diseases with high accuracy and comprehensiveness offers significant potential for developing forest inspection protection and prevention plans. However, limitations exist in the model’s performance in complex forest environments, necessitating further research to improve model universality and adaptability across diverse forest regions. Future directions include exploring advanced deep object detection models to minimize computing resource demands and enhance practical application support for forest protection and pest control. Full article

Tea plants have a long cultivation history in the world, but there are few studies on polysaccharides from fresh tea leaves. In this study, tea polysaccharides (TPSs) were isolated from fresh tea leaves. Then, we investigated the characteristics of TPSs during in vitro simulated digestion and fermentation; moreover, the effects of TPSs on gut microbiota were explored. The results revealed that saliva did not significantly affect TPSs’ molecular weight, monosaccharide composition, and reducing sugar content, indicating that TPSs cannot be digested in the oral cavity. However, TPSs were partially decomposed in the gastrointestinal tract after gastric and intestinal digestion, resulting in the release of a small amount of free glucose monosaccharides. Our in vitro fermentation experiments demonstrated that TPSs are degraded by gut microbiota, leading to short-chain fatty acid (SCFA) production and pH reduction. Moreover, TPSs increased the abundance of Bacteroides, Lactobacillus, and Bifidobacterium but reduced that of Escherichia, Shigella, and Enterococcus, demonstrating that TPSs can regulate the gut microbiome. In conclusion, TPSs are partially decomposed by gut microbiota, resulting in the production of SCFAs and the regulation of gut microbiota composition and function. Therefore, TPSs may be used to develop a prebiotic supplement to regulate the gut microbiome and improve host health. Full article

A time-dependent third-order shear deformation theory (TSDT) approach on the displacements of thick functionally graded material (FGM) conical shells under dynamic thermal vibration is studied. Dynamic equations of motion with TSDT for thick FGM conical shells are applied directly with the partial derivative of variable R*$\theta$ in the curve coordinates (x, $\theta$, z) instead of y in the Cartesian coordinates (x, y, z) for thick FGM plates, where R* is the middle-surface radius at any point on conical shells. The generalized differential quadrature (GDQ) numerical method is used to solve the dynamic differential equations in equilibrium matrix forms under thermal loads. It is the novelty of the current study to identify the parametric effects of shear correction coefficient, environment temperature, TSDT model, and FGM power law index on the displacements and stresses in the thick conical shells only subjected to sinusoidal heating loads. The physical parts with values on the length-to-thickness ratio equals 5, and 10 FGMs can be used in an area of an airplane engine that usually operates near more than 1000 K of temperatures when the thermal stress is considered and affected. The important findings of the presented study are listed as follows. The values of normal stress are in decreasing tendencies with time in cases when the coefficient $c_1$ equals 0.925925/mm² in TSDT and length-to-thickness ratio equals 5. The shear stress values in x plane z direction on the minor middle-surface radius (r) equals the major middle-surface radius (R) over 8 and length-to-thickness ratio equals to 5 can withstand T = 1000 K of pressure. Full article

The conformation of tetrahydrofuran (THF) molecules in vapor has been the subject of considerable computational and experimental studies, the most recent by Park and Kwon stated that the difference between the most stable, twisted C₂ conformer and the bent C_s conformer is 17 ± 15 cm⁻¹. Because of low symmetry, all modes from both conformers are allowed in the Raman and infrared spectra. In 1982, Aleksanyan and Antipov observed the emergence of two Raman bands at 249 and 303 cm⁻¹ at 20 K, while only one band at 293 cm⁻¹ was present in solid THF at 142. They assigned the 249 cm⁻¹ band to the restricted pseudorotational motion of THF in the solid state, because on heating, the band diminishes and is too weak to be observed near melting point (at 142 K). Cadioli et al. reported a study of the vibrational spectrum of tetrahydrofuran, giving a complete assignment of all bands including those present in the low-temperature Raman spectrum at 85 K and infrared bands observed at 90 K. They assigned the band at 242 cm⁻¹ in the Raman spectrum at 85 K as an overtone of the lowest normal mode (pseudorotational mode), while the 299 cm⁻¹ band in the same spectrum was assigned as a radial mode. In the following, low-temperature Raman spectra of solid THF together with the Raman matrix isolated spectrum of THF in air will be presented and compared to published data. Our results indicate that the band observed at 245 cm⁻¹ at 10 K is too strong to be assigned as an overtone, since its intensity is of the same magnitude as the 299 cm⁻¹ band. Full article

Numerous species of animals alter their behavior in response to increasing competition. To do so, they must possess the ability to detect the presence and density of interspecific competitors. We studied the role of semiochemicals released by increasing densities of larval Culiseta longiareolata Macquart on female oviposition habitat selection in two field experiments. Similarly to C. longiareolata larvae, subordinate Culex laticinctus Edwards are periphyton grazers who dwell in rain-filled pools in the Mediterranean region. We show that C. laticinctus females oviposited significantly less in mesocosm pools that were treated with crowding signals originating from C. longiareolata larvae. In the second experiment, we placed a similar number of larvae directly inside the 50 L mesocosms. These low-density mesocosms did not affect C. laticinctus oviposition but were attractive to conspecific oviposition. These results increase our understanding of the female ability to detect species-specific signals, indicating increased larval competition. Full article

This study examines the kinetics and mechanism of the oxygen reduction reaction (ORR) on a polycrystalline rhodium electrode (Rh(poly)) in acidic and alkaline media, using rotating disc electrode measurements. This study found that the ORR activity of the Rh(poly) electrode decreases in the order of 0.1 M NaOH > 0.1 M HClO₄ > 0.05 M H₂SO₄ concerning the half-wave potentials. The Tafel slopes for ORR on Rh(poly) in the cathodic direction are 60 and 120 mV dec⁻¹ at low and high overpotentials, respectively, in perchloric acid and alkaline solutions. However, strongly adsorbed sulfate anions hinder the ORR on Rh(poly) in sulfuric acid, leading to higher Tafel slopes. The highest ORR activity of Rh(poly) in an alkaline media suggests the promoting role of the specifically adsorbed OH⁻ anions and RhOH. In all cases, ORR on Rh(poly) proceeds through the 4e-series reaction pathway. Full article

Mammalian oocyte development depends on the temporally controlled translation of maternal transcripts, particularly in the coordination of meiotic and early embryonic development when transcription has ceased. The translation of mRNA is regulated by various RNA-binding proteins. We show that the absence of cytoplasmic polyadenylation element-binding protein 3 (CPEB3) negatively affects female reproductive fitness. CPEB3-depleted oocytes undergo meiosis normally but experience early embryonic arrest due to a disrupted transcriptome, leading to aberrant protein expression and the subsequent failure of embryonic transcription initiation. We found that CPEB3 stabilizes a subset of mRNAs with a significantly longer 3’UTR that is enriched in its distal region with cytoplasmic polyadenylation elements. Overall, our results suggest that CPEB3 is an important maternal factor that regulates the stability and translation of a subclass of mRNAs that are essential for the initiation of embryonic transcription and thus for embryonic development. Full article

This paper studies distributed optimal control for non-cooperative systems involving time-fractional hyperbolic operators. Through the application of the Lax–Milgram theorem, we confirm the existence and uniqueness of weak solutions. Central to our approach is the utilization of the linear quadratic cost functional, which is meticulously crafted to encapsulate the interplay between the system’s state and control variables. This functional serves as a pivotal tool in imposing constraints on the dynamic system under consideration, facilitating a nuanced understanding of its controllability. Using the Euler–Lagrange first-order optimality conditions with an adjoint problem defined by means of the right-time fractional derivative in the Caputo sense, we obtain an optimality system for the optimal control. Finally, some examples are analyzed. Full article

Water pollution, particularly from heavy metals, poses a significant threat to global health, necessitating efficient and environmentally friendly removal methods. This study introduces novel zeolite-based adsorbents, specifically alkali-activated foamed zeolite (AAFZ), for the effective adsorption of Cu(II) and Ni(II) ions from aqueous solutions. The adsorbents’ capabilities were comprehensively characterized through kinetic and isotherm analyses. Alkaline activation induced changes in chemical composition and crystalline structure, as observed via XRF and XRD analyses. AAFZ exhibited a significantly larger pore volume (1.29 times), higher Si/Al ratio (1.15 times), and lower crystallinity compared to ZZ50, thus demonstrating substantially higher adsorption capacity for Cu(II) and Ni(II) compared to ZZ50. The maximum monolayer adsorption capacities of ZZ50 and AAFZ for Cu(II) were determined to be 69.28 mg/g and 99.54 mg/g, respectively. In the case of Ni(II), the maximum monolayer adsorption capacities for ZZ50 and AAFZ were observed at 48.53 mg/g and 88.99 mg/g, respectively. For both adsorbents, the optimum pH for adsorption of Cu(II) and Ni(II) was found to be 5 and 6, respectively. Equilibrium was reached around 120 min, and the pseudo-second-order kinetics accurately depicted the chemisorption process. The Langmuir isotherm model effectively described monolayer adsorption for both adsorbents. Furthermore, the regeneration experiment demonstrated that AAFZ could be regenerated for a minimum of two cycles using hydrochloric acid (HCl). These findings highlight the potential of the developed adsorbents as promising tools for effective and practical adsorption applications. Full article

This study introduces a decision support framework that integrates aircraft trajectory optimization and arrival scheduling to facilitate efficient management of descent operations for arriving aircraft within terminal maneuvering areas. The framework comprises three modules designed to tackle specific challenges in the descent process. The first module formulates and solves a trajectory optimization problem, generating a range of candidate descent trajectories for each arriving aircraft. The options for descent operations include step-down descent operation, Continuous Descent Operation (CDO), and CDO with a lateral path stretching strategy. The second module addresses the assignment of conflict-free trajectories to aircraft, determining precise arrival times at each waypoint. This is achieved by solving an aircraft arrival scheduling problem. To overcome computational complexities, a novel variable neighborhood search algorithm is proposed as the solution approach. This algorithm utilizes three neighborhood structures within an extended relaxing and solving framework, and incorporates a tabu search algorithm to enhance the efficiency of the search process in the solution space. The third module focuses on comparing the total cost incurred from flight delays and fuel consumption across the three descent operations, enabling the selection of the most suitable operation for the descent process. The decision support framework is evaluated using real air traffic data from Guangzhou Baiyun International Airport. Experimental results demonstrate that the framework effectively supports air traffic controllers by scheduling more cost-efficient descent operations for arrival aircraft. Full article

Rembang Regency is located on the north coast of Java Island, Central Java Province, Indonesia, which has many beaches ideal for tourism activities. Even though it has the charm of beaches, natural tourist destinations are still the primary choice compared to cultural and artificial sites. However, limited studies exist regarding standard indicators for assessing natural tourism potential in Rembang Regency, which is essential for identifying potential tourist locations. This research focuses on grouping indicators of natural tourism potential based on six main aspects: attractions, amenities, accommodation, activity, accessibility, and ancillary services, environment in tourist areas, and human resources considerations. A taxonomic model will be utilized to develop a procedure for determining natural tourism potential, including indicator weighing via a hierarchical analysis. The findings will yield a taxonomy model aiding information and knowledge management, fostering information sharing and utilization. Moreover, the established procedures will facilitate an accurate and efficient determination of natural tourism potential. This research aims to contribute to sustainable natural tourism management in Rembang Regency, preserving nature while enhancing the tourist experience. Full article

The linearization of nonlinear differential equations represents a robust approach to solution derivation, typically achieved through Lie symmetry analysis. This study adopts a geometric methodology grounded in the Eisenhart lift, revealing transformative techniques that linearize a set of second-order ordinary differential equations. The research underscores the effectiveness of this geometric approach in the linearization of a class of Newtonian systems that cannot be linearized through symmetry analysis. Full article

The β-adrenergic drug Mirabegron, a drug initially used for the treatment of an overactive bladder, has new potential indications and is hydrolyzed by butyrylcholinesterase (BChE). This compound is one of the only arylacylamide substrates to be catabolized by BChE. A steady-state kinetic analysis at 25°C and pH 7.0 showed that the enzyme behavior is Michaelian with this substrate and displays a long pre-steady-state phase characterized by a burst. The induction time, τ, increased with substrate concentration (τ≈18 min at maximum velocity). The kinetic behavior was interpreted in terms of hysteretic behavior, resulting from a slow equilibrium between two enzyme active forms, E and E’. The pre-steady-state phase with the highest activity corresponds to action of the E form, and the steady state corresponds to action of the E’ form. The catalytic parameters were determined as k_cat = 7.3 min⁻¹ and K_m = 23.5 μM for the initial (burst) form E, and k_cat = 1.6 min⁻¹ and K_m = 3.9 μM for the final form E’. Thus, the higher affinity of E’ for Mirabegron triggers the slow enzyme state equilibrium toward a slow steady state. Despite the complexity of the reaction mechanism of Mirabegron with BChE, slow BChE-catalyzed degradation of Mirabegron in blood should have no impact on the pharmacological activities of this drug. Full article

Background: Several risk scores have been derived to predict the risk of infective endocarditis (IE) amongst patients with Staphylococcus aureus bacteraemia (SAB), which helps to guide clinical management. Methods: We prospectively studied 634 patients admitted with SAB. The cohort was stratified into those with or without IE, and the PREDICT Day 1, Day 5 and VIRSTA scores were tabulated. Area under the receiver operating characteristic (AUC) curves were constructed to compare the performance of each score. Results: Of the 634 patients examined, 36 (5.7%) had IE. These patients were younger (51.6 ± 20.1 vs. 59.2 ± 18.0 years, p = 0.015), tended to have community acquisition of bacteraemia (41.7% vs. 17.9%, p < 0.001), and had persistent bacteraemia beyond 72 h (19.4% vs. 6.0%, p = 0.002). The VIRSTA score had the best performance in predicting IE (AUC 0.76, 95%CI 0.66–0.86) compared with PREDICT Day 1 and Day 5. A VIRSTA score of <3 had the best negative predictive value (97.5%), compared with PREDICT Day 1 (<4) and Day 5 (<2) (94.3% and 96.6%, respectively). Conclusions: Overall, the risk scores performed well in our Asian cohort. If applied, 23.5% of the cohort with a VIRSTA ≥ 3 would require TEE, and a score of <3 had an excellent negative predictive value. Full article