Background/Objectives: Patients with rheumatoid arthritis (RA) are prone to develop infections. Methods: Accordingly, 195 untreated early (e)RA patients and 398 healthy controls were selected from women in Tatarstan’s cohort to study infectious history in the anamnesis (four criteria) and in the previous year (16 criteria). Information about annual infections was collected face-to-face from year to year by a qualified rheumatologist/ general practitioner and included the active use of information from medical records. Results: In the anamnesis, tuberculosis, and pneumonia, and in the previous year, respiratory tract infections, skin infections, and herpes simplex virus reactivation incidence were reported to be increased in eRA patients, as well as the event number and duration of acute and chronic tonsillitis. Moreover, more bacterial-suspected upper respiratory infections and urinary tract infections were retrieved in sporadic eRA patients as compared to familial eRA patients. An elevated immunization against CCP prevented respiratory tract infection in those with HSV exacerbation. Finally, associations were retrieved between infection (event number/delay) and RA indices: (i) chronic tonsillitis exacerbations with disease activity and health assessment (HAQ) in familial eRA; (ii) bacterial-suspected upper respiratory infections with the number of swollen and tender joints in sporadic eRA; and (iii) HSV exacerbation with inflammation in eRA patients with negative/low response against CCP. Here, we demonstrate the complex nature of the interplay of RA with specific infections. Conclusions: For the first time, differences in the patterns of annual trivial infections and their links with RA indices were found in cohorts of familial and sporadic cases of the disease. Additionally, for the first time, we identified a remarkable relationship between early RA and exacerbations of chronic tonsillitis, as well as tuberculosis in the patient’s history. Altogether, this study supports the existence of a complex interplay between infections and RA at onset driven by familial status and the presence of anti-CCP Ab at elevated levels. Full article

Heparin products are frequently used in the inpatient setting to prevent and treat venous thromboembolism, but they simultaneously put patients at risk of developing heparin-induced thrombocytopenia (HIT). The 4Ts score determines the pretest probability of HIT. Diagnosis is made with a screening antiplatelet factor (PF4) immunoassay and the serotonin-release assay (SRA) as a confirmatory test. Anti-PF4 assays have high sensitivity (98%) but lower specificity (50%) and result in frequent false-positive tests. We present a rare case from our institution of a patient with anti-PF4–Polyanion ELISA-negative, SRA-positive HIT and describe the challenges in making a timely diagnosis in this case. Full article

The recent seismic activity highlights the crucial need to enhance seismic design and safety assessment methods, particularly for irregular structures, in both new and existing constructions. The present study focuses on structural irregularities in elevation for buildings, as the design of structural systems involves multiple variables that often result in irregularities in many buildings. This work aims to perform a comparative assessment of the criteria adopted for the evaluation of the structural irregularities in elevation present in European and international seismic codes. This paper is structured as follows: Firtsly, it discusses structural irregularities and more specifically the most common types of structural damage due to seismic events. Then, it shows the documented experiences of structural damages in seismic events associated with structural irregularities in China, Italy, Spain, Nepal and Mexico. Additionaly, it discusses the requirements of the standards on irregularities and their limitation in that matter. At the end of this section, the different approaches of each code in irregularities in elevation are compared. All assessed seismic codes addresses the structural irregularity issue, attributing the desired characteristics of a seismic-resistant structure. However, there are considerable development differences between norms, demonstrated on ambiguity of few codes on criteria of vertical irregularies. Full article

Coating technology, as a part of surface engineering, has shown remarkable potential in future industrial applications. With the continuous development and improvement of coating technology, coatings have gradually become an indispensable part of industrial manufacturing, possessing various excellent properties and characteristics, such as superhydrophobicity and self-cleaning, enhanced biological antibacterial properties, and improved corrosion resistance. Intelligent coatings are not only rigid barriers between substrates and the environment but also coatings designed to respond to the environment and improve coating life or achieve certain special functions through this response. Biomimetics is a discipline that studies the structure, function, and behavior of living organisms and applies them to engineering design. Combining bionics with intelligent coating materials can not only improve the performance and functionality of intelligent coatings but also create more intelligent coating materials. This paper includes advanced superhydrophobic intelligent coatings, anticorrosion intelligent coatings, biological antibacterial intelligent coatings, and other intelligent coatings with specific functions. We also provide a detailed overview of the preparation methods and technologies of various representative intelligent coatings, as well as their properties and applications, which will offer some valuable references for the development direction of future intelligent coatings. Full article

Common ragweed pollen allergy has become a health burden worldwide. One of the major allergens in ragweed allergy is Amb a 1, which is responsible for over 90% of the IgE response in ragweed-allergic patients. The major allergen isoform Amb a 1.01 is the most allergenic isoform in ragweed pollen. So far, no recombinant Amb a 1.01 with similar allergenic properties to its natural counterpart (nAmb a 1.01) has been produced. Hence, this study aimed to produce a recombinant Amb a 1.01 with similar properties to the natural isoform for improved ragweed allergy management. Amb a 1.01 was expressed in insect cells using a codon-optimized DNA construct with a removable N-terminal His-Tag (rAmb a 1.01). The recombinant protein was purified by affinity chromatography and physicochemically characterized. The rAmb a 1.01 was compared to nAmb a 1.01 in terms of the IgE binding (enzyme-linked immunosorbent assay (ELISA), immunoblot) and allergenic activity (mediator release assay) in well-characterized ragweed-allergic patients. The rAmb a 1.01 exhibited similar IgE reactivity to nAmb a 1.01 in different IgE-binding assays (i.e., IgE immunoblot, ELISA, quantitative ImmunoCAP inhibition measurements). Furthermore, the rAmb a 1.01 showed comparable dose-dependent allergenic activity to nAmb a 1.01 regarding basophil activation. Overall, the results showed the successful expression of an rAmb a 1.01 with comparable characteristics to the corresponding natural isoform. Our findings provide the basis for an improvement in ragweed allergy research, diagnosis, and immunotherapy. Full article

The service model of digital agricultural technology extension, as a novel and sustainable approach, plays a pivotal role in facilitating the digital transformation of farmers’ agricultural practices. Leveraging survey data from 1475 farmers in China, the study employed a multivariate ordered logit model to investigate the relationship between farmers’ cognition and enthusiasm to adopt digital agricultural extension services. The findings revealed that subjective and objective cognitions positively influence farmers’ enthusiasm for adopting digital agricultural extension services. Furthermore, policy incentives, as a significant regulatory factor, effectively influence farmers’ cognition levels and enthusiasm to adopt digital agricultural extension services. Additionally, female respondents, farmers with higher educational levels, and membership in agricultural cooperatives all facilitate the adoption of these services. This study not only enriches the theoretical framework for agricultural technology promotion, aiding in the understanding of farmers’ decision-making processes when adopting digital agricultural extension services, but also provides a deeper insight into the role of digital agricultural technologies in promoting sustainable agricultural development, offering scientific evidence for relevant policy formulation and implementation. Full article

In this work, a modified numerical algorithm that couples the quasi-static theory with the mixed thermal elastohydrodynamic lubrication (mixed-TEHL) model is proposed to examine the mechanical properties and lubrication performance of the spindle bearing that is used in a high-speed machine tool with spinning. The non-Newtonian fluid characteristics of the lubricant and the non-Gaussian surface roughness are also considered. Moreover, the mechanical properties and lubrication state of the bearing are examined in various service environments. The results indicate that the temperature reduces the lubrication efficiency, which in turn exerts a significant impact on the mechanical properties. The lubrication that either behaves in the manner of Newtonian or non-Newtonian fluid has a relatively negligible influence on the bearing working state, while the non-Gaussian surface roughness significantly alters the oil film thickness and temperature. Calculations with different operating conditions demonstrate that the operating parameters (i.e., axial load, rotation speed) will directly affect the performance of the bearings via the changes in the oil film thickness and the temperature. Full article

We identified Wdr17 as a highly expressed gene in pachytene spermatocytes by transcriptomic analysis of mouse testis. Germ cell-deficient infertile mouse models had significantly reduced Wdr17 expression. We performed gene interference and overexpression in the mouse spermatocyte cell line GC-2spd(ts) and investigated how Wdr17 affects spermatocyte growth and development. Our results showed that Wdr17 suppression significantly decreased cell growth rate and increased cell apoptosis in GC-2spd(ts) cells. Wdr17 suppression also arrested the cell cycle at the G1 phase. On the contrary, Wdr17 overexpression significantly promoted cell proliferation and inhibited cell apoptosis in GC-2spd(ts) cells. More cells were enriched at the S stage with a concomitant reduction of cells at the G1 stage. Wdr17 promotes mouse spermatocyte proliferation by advancing cell cycle progression and inhibiting cell apoptosis, indicating its potential role in regulating spermatogenesis in the mouse. Full article

This paper considers the confrontation problem for two tank swarms of equal size and capability in a complex urban scenario. Based on the Unity platform (2022.3.20f1c1), the confrontation scenario is constructed featuring multiple crossing roads. Through the analysis of a substantial amount of biological data and wildlife videos regarding animal behavioral strategies during confrontations for hunting or food competition, two strategies are been utilized to design a novel bio-inspired intelligent swarm confrontation algorithm. The first one is the “fire concentration” strategy, which assigns a target for each tank in a way that the isolated opponent will be preferentially attacked with concentrated firepower. The second one is the “back and forth maneuver” strategy, which makes the tank tactically retreat after firing in order to avoid being hit when the shell is reloading. Two state-of-the-art swarm confrontation algorithms, namely the reinforcement learning algorithm and the assign nearest algorithm, are chosen as the opponents for the bio-inspired swarm confrontation algorithm proposed in this paper. Data of comprehensive confrontation tests show that the bio-inspired swarm confrontation algorithm has significant advantages over its opponents from the aspects of both win rate and efficiency. Moreover, we discuss how vital algorithm parameters would influence the performance indices. Full article

Multidrug-resistant bacterial pathogens, such as E. coli, represent a major human health threat. Due to the critical need to overcome this dilemma, since the drug efflux pump has a vital function in the evolution of antimicrobial resistance in bacteria, we have investigated the potential of Mentha essential oil major constituents (1–19) as antimicrobial agents via their ability to inhibit pathogenic DNA gyrase and, in addition, their potential inhibition of the E. coli AcrB-TolC efflux pump, a potential target to inhibit MDR pathogens. The ligand docking approach was conducted to analyze the binding interactions of Mentha EO constituents with the target receptors. The obtained results proved their antimicrobial activity through the inhibition of DNA gyrase (1kzn) with binding affinity ΔG values between −4.94 and −6.49 kcal/mol. Moreover, Mentha EO constituents demonstrated their activity against MDR E. coli by their ability to inhibit AcrB-TolC (4dx7) with ΔG values ranging between −4.69 and −6.39 kcal/mol. The antimicrobial and MDR activity of Mentha EOs was supported via hydrogen bonding and hydrophobic interactions with the key amino acid residues at the binding site of the active pocket of the targeted receptors. Full article

Measuring postural control in an upright standing position is the standard method. However, this diagnostic method has floor or ceiling effects and its implementation is only possible to a limited extent. Assessing postural control directly on the trunk in a sitting position and consideration of the results in the spectrum in conjunction with an AI-supported evaluation could represent an alternative diagnostic method quantifying neuromuscular control. In a prospective cross-sectional study, 188 subjects aged between 18 and 60 years were recruited and divided into two groups: “LowBackPain” vs. “Healthy”. Subsequently, measurements of postural control in a seated position were carried out for 60 s using a modified balance board. A spectrum per trail was calculated using the measured CoP tracks in the range from 0.01 to 10 Hz. Various algorithms for data classification and prediction of these classes were tested for the parameter combination with the highest proven static influence on the parameter pain. The best results were found in a frequency spectrum of 0.001 Hz and greater than 1 Hz. After transforming the track from the time domain to the image domain for representation as power density, the influence of pain was highly significant (effect size 0.9). The link between pain and gender (p = 0.015) and pain and height (p = 0.012) also demonstrated significant results. The assessment of postural control in a seated position allows differentiation between “LowBackPain” and “Healthy” subjects. Using the AI algorithm of neural networks, the data set can be correctly differentiated into “LowBackPain” and “Healthy” with a probability of 81%. Full article

Two ancient wooden vessels, specifically a monoxyle (1st century BCE to 1st century CE) and shipwreck (15th to 17th century CE), were excavated in a well-preserved state east of the confluence of the old Mlava and the Danube rivers (Serbia). The vessels were found in the ground that used to be river sediment and were temporarily stored within the semi-underground exhibition space of Mammoth Park. As part of the pre-conservation investigations, the primary aim of the research presented was to characterize the culturable mycobiomes of two excavated wooden artifacts so that appropriate conservation procedures for alleviating post-excavation fungal infestation could be formulated. Utilizing culture-based methods, a total of 32 fungi from 15 genera were identified, mainly Ascomycota and to a lesser extent Mucoromycota sensu stricto. Soft-rot Ascomycota of genus Penicillium, followed by Aspergillus and Cephalotrichum species, were the most diverse of the isolated fungi. Out of a total of 38 isolates, screened on 7 biodegradation plate assays, 32 (84.21%) demonstrated at least one degradative property. Penicillium solitum had the highest deterioration potential, with a positive reaction in 5 separate plate assays. The obtained results further broaden the limited knowledge on the peculiarities of post-excavation soft-rot decay of archaeological wood and indicate the biochemical mechanisms at the root of post-excavation fungal deterioration. Full article

China’s small arched shed-building machinery suffers from a low degree of mechanization, building efficiency, and qualification rate for frame insertion. Therefore, we designed a rotary double-insertion device and established the equation for its motion trajectory. The analysis shows that in the rotary insertion process, a better point of entry into the soil exists. A simulation model was constructed in ADAMS, and the static and dynamic trajectories were analyzed. Additionally, the optimal planting and insertion speed ratios were determined. Considering the qualified rate of the insertion frame as the evaluation index to establish a regression model, we adopted a three-factor three-level experimental design and established the planting speed ratio, center distance of the planting arm, and length of the pressing rod arm as the main influencing factors. We used Design-Expert 13 to perform the analysis of variance and determined the optimal parameter combinations. The experimental results show that the planting speed ratio was 0.7, the center distance of the planting arm group was 554 mm, the length of the pressing rod arm was 923 mm, and the qualification rate of trellis planting at this time was 98.05%. The bench was adjusted and tested based on the optimal parameter combination. The average value of the measured trellis qualification rate was 96.73%, and the relative error between the test value and the theoretical optimization value was 1.32%, thereby verifying the reliability of the optimal parameter combination. Field verification test results show that the rotary double-insertion device had a planting speed ratio of 0.7 and a trellis qualified rate of 95.74% compared with the theoretical optimization value of 2.31%. Conforming to the design requirements of small arch shed-building machinery, the prototype operation performance was stable. Full article

The etiology of colon cancer is either genetic in nature or results from inflammatory bowel diseases such as ulcerative colitis and Crohn’s disease; nevertheless, dietary habits play a crucial role in the disease. Wheatgrass is a dietary supplement that is rich in vitamins, minerals, and antioxidants which contribute to health promotion in cardiovascular diseases, liver disease, blood diseases, diabetes, and inflammatory bowel diseases, as well as in several types of cancers, such as oral squamous cell cancer, cervical cancer, and breast cancer. In colorectal cancer (CRC), the prospect that wheatgrass possesses anti-inflammatory, antioxidant, and anticancer properties, and its use as an adjunctive therapy, have been minimally investigated and evidence is still limited. In this review, we compiled the available evidence pertaining to wheatgrass and its likely impact on CRC, described the pathways of inflammation in which wheatgrass could possibly play a role, and identified future research needs on the subject. Full article

This paper proposes a dual-loop discrete-time adaptive control (DDAC) method for three-phase PWM rectifiers, which considers inductance-parameter-mismatched and DC load disturbances. A discrete-time model of the three-phase PWM rectifier is established using the forward Euler discretization method, and a dual-loop discrete-time feedback linearization control (DDFLC) is given. Based on the DDFLC, the DDAC is designed. Firstly, an adaptive inductance disturbance observer (AIDO) based on the gradient descent method is proposed in the current control loop. The AIDO is used to estimate lump disturbances caused by mismatched inductance parameters and then compensate for these disturbances in the current controller, ensuring its strong robustness to inductance parameters. Secondly, a load parameter adaptive law (LPAL) based on the discrete-time Lyapunov theory is proposed for the voltage control loop. The LPAL estimates the DC load parameter in real time and subsequently adjusts it in the voltage controller, achieving DC load adaptability. Finally, simulation and experimental results show that the DDAC exhibits better steady and dynamic performances, less current harmonic content than the DDFLC and the dual-loop discrete-time PI control (DDPIC), and a stronger robustness to inductance parameters and DC load disturbances. Full article

BIM and 4.0 technologies are currently the leading branches of digitization in construction. The aim of this article is to confront theses on building information modeling (BIM) and coexisting technologies, and to present an analysis along with conclusions regarding the digitization process of AEC industries using BIM methodology and advanced digital technologies within the scope of 4.0 technologies. Key aspects of BIM and 4.0 technology integration were discussed, including artificial intelligence (AI) or big data and data science analytics. The impact of these fields on design processes, as well as on data management, monitoring of design and construction progress, and overall efficiency of AEC industries, was analyzed. The article pays particular attention to the synergy between BIM and 4.0 technology, identifying benefits, challenges, and development perspectives. Conclusions indicate the growing importance of interdisciplinarity for improving AEC industry processes and the need to adapt to the changing digital landscape in the field of design and construction. A survey was conducted, where respondents’ answers were presented in the form of charts. Questions focused on the issue of the use of BIM methodology along with coexisting technologies in the design process by the Polish engineering staff. The research results indicate that the use of the latest technological solutions in Poland is still rare, and the digital potential of these solutions is not fully utilized. The article can make a significant contribution to the discussion on technological evolution in AEC industries, identifying development directions in the context of digitization and the use of the latest achievements of 4.0 technology. Previous research has not included such a wide spectrum of BIM use in Poland. An analysis was conducted comparing Poland in a global context with other countries in BIM adoption. Full article

Hair cosmetics are in fashion. Numerous products are commonly used in combination. Frequent allergens are present in hair cosmetics, which, with almost daily use, increase the risk of sensitization. Familiarity with the clinical distribution of the eczematous rash is necessary to seriously consider patch testing. Not all the products on the market are haptens. It is necessary to know how to patch your own products. When avoidance of the allergen is not possible, new treatments are evaluated to combat allergic contact dermatitis, mainly of the occupational type. In this manuscript, a complete and practical review of the main allergens and contact sources of hair cosmetic origin has been carried out. Full article

This paper integrates intelligent reflecting surfaces (IRS) with unmanned aerial vehicles (UAV) to enhance the transmission performance of the Internet of Vehicles (IoV) through non-orthogonal multiple access (NOMA). It focuses on strengthening the signals from cell edge vehicles (CEVs) to the base station by optimizing the wireless propagation environment via an IRS-equipped UAV. The primary goal is to maximize the sum data rate of CEVs while satisfying the constraint of the successive interference cancellation (SIC) decoding threshold. The challenge lies in the non-convex nature of jointly considering the power control, subcarrier allocation, and phase shift design, making the problem difficult to optimally solve. To address this, the problem is decomposed into two independent subproblems, which are then solved iteratively. Specifically, the optimal phase shift design is achieved using the deep deterministic policy gradient (DDPG) algorithm. Furthermore, the graph theory is applied to determine the subcarrier allocation policy and derive a closed-form solution for optimal power control. Finally, the simulation results show that the proposed joint phase shift and resource management scheme significantly enhances the sum data rate compared to the state-of-the-art schemes, thereby demonstrating the benefits of integrating the IRS-equipped UAV into NOMA-enhanced IoV. Full article

Hyperspectral images (HSI) find extensive application across numerous domains of study. Spectral superresolution (SSR) refers to reconstructing HSIs from readily available RGB images using the mapping relationships between RGB images and HSIs. In recent years, convolutional neural networks (CNNs) have become widely adopted in SSR research, primarily because of their exceptional ability to extract features. However, most current CNN-based algorithms are weak in terms of extracting the spectral features of HSIs. While certain algorithms can reconstruct HSIs through the fusion of spectral and spatial data, their practical effectiveness is hindered by their substantial computational complexity. In light of these challenges, we propose a lightweight network, Transformer with convolutional spectral self-attention (TCSSA), for SSR. TCSSA comprises a CNN-Transformer encoder and a CNN-Transformer decoder, in which the convolutional spectral self-attention blocks (CSSABs) are the basic modules. Multiple cascaded encoding and decoding modules within TCSSA facilitate the efficient extraction of spatial and spectral contextual information from HSIs. The convolutional spectral self-attention (CSSA) as the basic unit of CSSAB combines CNN with self-attention in the transformer, effectively extracting both spatial local features and global spectral features from HSIs. Experimental validation of TCSSA’s effectiveness is performed on three distinct datasets: GF5 for remote sensing images along with CAVE and NTIRE2022 for natural images. The experimental results demonstrate that the proposed method achieves a harmonious balance between reconstruction performance and computational complexity. Full article

In response to the challenges introduced by global warming and increased eutrophication, this paper presents an innovative modeling and simulation (M&S)-driven model for developing an automated inland water monitoring system. This system is grounded in a layered Internet of Things (IoT) architecture and seamlessly integrates cloud, fog, and edge computing to enable sophisticated, real-time environmental surveillance and prediction of harmful algal and cyanobacterial blooms (HACBs). Utilizing autonomous boats as mobile data collection units within the edge layer, the system efficiently tracks algae and cyanobacteria proliferation and relays critical data upward through the architecture. These data feed into advanced inference models within the cloud layer, which inform predictive algorithms in the fog layer, orchestrating subsequent data-gathering missions. This paper also details a complete development environment that facilitates the system lifecycle from concept to deployment. The modular design is powered by Discrete Event System Specification (DEVS) and offers unparalleled adaptability, allowing developers to simulate, validate, and deploy modules incrementally and cutting across traditional developmental phases. Full article

The excessive intake of sodium (Na) and insufficient intake of potassium (K) are major concerns in the prevention of hypertension. Using low-Na/K seasonings (reducing 25% of the NaCl and adding K salt) may improve the dietary Na/K ratio and help prevent hypertension. To devise an intervention study using low-Na/K seasonings at a company cafeteria, we calculated the Na and K contents of the meals served at the cafeteria and estimated changes in the intakes when suitable low-Na/K seasonings were used. We also considered using milk as a good source of K. We used an ingredient list of a company cafeteria and calculated Na and K contents in each dish. The average amounts of NaCl and K per use were 5.04 g and 718 mg, respectively. Seasonings contributed 70.9% of the NaCl. With the use of low-Na/K seasonings, an estimated reduction in NaCl of 0.8 g/day and an estimated increase in K of 308 mg/day was achieved. With an additional serving (200 mL) of milk, NaCl was reduced by 0.57 g/day and K was increased by 610 mg/day, with an overall decrease in the dietary Na/K ratio from 3.20 to 2.40. The use of low-Na/K seasonings and dairy may improve the dietary Na/K ratio among cafeteria users and help prevent hypertension. Full article

The built environment has been linked to physical activity (PA) behaviors, yet there is limited knowledge of this association among lower-income midlife and older adults who are insufficiently active. The present cross-sectional study utilized baseline data collected between October 2017 and November 2019 from a clustered randomized controlled trial to determine how built environment attributes were associated with PA behaviors among midlife and older adults (n = 255) residing in or near affordable housing sites (n = 10). At each site, perceptions of the built environment were collected and scored at the participant level via the abbreviated Neighborhood Environment Walkability Survey (NEWS-A), while objective built environment attributes were measured and scored by trained research staff using the Physical Activity Resource Assessment (PARA). Multiple PA behaviors—walking, total PA, and moderate-to-vigorous PA (MVPA) (min/wk)—were measured using the validated Community Healthy Activities Model Program for Seniors (CHAMPS) questionnaire. Adjusted linear regression models examined associations between NEWS-A measures and PA behaviors, and site-level correlations between PARA measures and PA behaviors were examined using Spearman’s rank correlations. At the participant level, adjusted models revealed that a one point increase in the NEWS-A aesthetics score was associated with a 57.37 min/wk increase in walking (β = 57.37 [95% CI: 20.84, 93.91], p = 0.002), with a similar association observed for street connectivity and MVPA (β = 24.31 min/wk [95% CI: 3.22, 45.41], p = 0.02). At the site level, MVPA was positively correlated with the quality of the features of local, PA-supportive environmental resources (ρ = 0.82, p = 0.004). Findings indicate that participant- and site-level measures of the built environment may play a role in promoting PA behavior among this demographic and similar populations. Results also suggest that improvements in aesthetic attributes and street connectivity, along with enhancing the quality of local, PA-supportive environmental resources, may be effective strategies for promoting physical activity among lower-income midlife and older adults. Full article