The 2023 MDPI Annual Report has
been released!
 
15 pages, 5368 KiB  
Review
Dynamic Hydrogels against Infections: From Design to Applications
by Ming Zhang and Chongyu Zhu
Gels 2024, 10(5), 331; https://doi.org/10.3390/gels10050331 (registering DOI) - 14 May 2024
Abstract
Human defense against infection remains a global topic. In addition to developing novel anti-infection drugs, therapeutic drug delivery strategies are also crucial to achieving a higher efficacy and lower toxicity of these drugs for treatment. The application of hydrogels has been proven to [...] Read more.
Human defense against infection remains a global topic. In addition to developing novel anti-infection drugs, therapeutic drug delivery strategies are also crucial to achieving a higher efficacy and lower toxicity of these drugs for treatment. The application of hydrogels has been proven to be an effective localized drug delivery approach to treating infections without generating significant systemic adverse effects. The recent emerging dynamic hydrogels further show power as injectable formulations, giving new tools for clinical treatments. In this review, we delve into the potential applications of dynamic hydrogels in antibacterial and antiviral treatments and elaborate on their molecular designs and practical implementations. By outlining the chemical designs underlying these hydrogels, we discuss how the choice of dynamic chemical bonds affects their stimulus responsiveness, self-healing capabilities, and mechanical properties. Afterwards, we focus on how to endow dynamic hydrogels with anti-infection properties. By comparing different drug-loading methods, we highlight the advantages of dynamic chemical bonds in achieving sustained and controlled drug release. Moreover, we also include the design principles and uses of hydrogels that possess inherent anti-infective properties. Furthermore, we explore the design principles and applications of hydrogels with inherent anti-infective properties. Finally, we briefly summarize the current challenges faced by dynamic hydrogels and present a forward-looking vision for their future development. Through this review, we expect to draw more attention to these therapeutic strategies among scientists working with chemistry, materials, as well as pharmaceutics. Full article
(This article belongs to the Special Issue State-of-the-Art Gel Research in China)
Show Figures

Graphical abstract

22 pages, 3068 KiB  
Article
Assessing the Need for and Environmental Acceptability of Infrastructural Facilities in Natural Areas with Special Management Status
by Natalia Lubsanova, Zehong Li, Svetlana Ayusheeva, Anna Mikheeva, Sembrika Ivanova, Taisiya Bardakhanova, Lyudmila Maksanova and Alexey Bilgaev
Sustainability 2024, 16(10), 4105; https://doi.org/10.3390/su16104105 (registering DOI) - 14 May 2024
Abstract
(1) Background: The article discusses approaches to assessing the ecological acceptability of locating new facilities in areas with special natural resource management status. The presence of natural resources and environmental constraints determine the activity of such facilities. We selected the Central Ecological Zone [...] Read more.
(1) Background: The article discusses approaches to assessing the ecological acceptability of locating new facilities in areas with special natural resource management status. The presence of natural resources and environmental constraints determine the activity of such facilities. We selected the Central Ecological Zone of the Baikal Natural Territory as the object of study, where the fundamental principle of economic activity is ecological, namely through the prevention of the harmful impacts of production, population, and business on the Lake Baikal ecosystems and the surrounding environment, as well as the restriction of certain types of economic activities and more stringent environmental regulation. The study aims to develop a methodological approach for assessing the ecological acceptability of locating facilities in areas with environmental constraints. (2) Methods: We analyzed the possible risks of locating new facilities based on determining the environmental impact of economic activities and assessing the environmental and associated socio-economic consequences of this impact. We determined the ecological acceptability of existing types of economic activities within the proposed approach based on a multi-criteria analysis, including an assessment of the state and possible changes in pollution flows and natural potential of the territories, the anthropogenic state of natural complexes, external and internal costs, and compliance with the status of natural resource management and regulations. (3) Results: The research results indicate that in most of the Central Ecological Zone of the Baikal Natural Territory, the location of new facilities is acceptable in terms of the balance between ecological capacity, anthropogenic load, and economic damage from pollution. However, when locating, it is necessary to consider restrictions on pollutant and contaminant standards, hydrological risks in certain sections of the coast, and the limited labor resources in the Severo-Baykalsky district. (4) Conclusions: The obtained analytical results can be used to scientifically substantiate the location of new facilities in areas with special natural resource management status since the main criterion postulated is that the anthropogenic load on the territory should not exceed the self-recovery potential of the territory’s natural complex. Full article
Show Figures

Figure 1

13 pages, 497 KiB  
Protocol
Effect of Intermittent vs. Continuous Energy Restriction on Visceral Fat: Protocol for The Healthy Diet and Lifestyle Study 2 (HDLS2)
by Michelle Y. Lewis, Kim Yonemori, Alison Ross, Lynne R. Wilkens, John Shepherd, Kevin Cassel, Andrew Stenger, Christoph Rettenmeier, Unhee Lim, Carol Boushey and Loïc Le Marchand
Nutrients 2024, 16(10), 1478; https://doi.org/10.3390/nu16101478 (registering DOI) - 14 May 2024
Abstract
Obesity in the United States and Western countries represents a major health challenge associated with an increased risk of metabolic diseases, including cardiovascular disease, hypertension, diabetes, and certain cancers. Our past work revealed a more pronounced obesity–cancer link in certain ethnic groups, motivating [...] Read more.
Obesity in the United States and Western countries represents a major health challenge associated with an increased risk of metabolic diseases, including cardiovascular disease, hypertension, diabetes, and certain cancers. Our past work revealed a more pronounced obesity–cancer link in certain ethnic groups, motivating us to develop a tailored dietary intervention called the Healthy Diet and Lifestyle 2 (HDLS2). The study protocol is described herein for this randomized six-month trial examining the effects of intermittent energy restriction (5:2 Diet) plus the Mediterranean dietary pattern (IER + MED) on visceral adipose tissue (VAT), liver fat, and metabolic biomarkers, compared to a standard MED with daily energy restriction (DER + MED), in a diverse participant group. Using MRI and DXA scans for body composition analysis, as well as metabolic profiling, this research aims to contribute to nutritional guidelines and strategies for visceral obesity reduction. The potential benefits of IER + MED, particularly regarding VAT reduction and metabolic health improvement, could be pivotal in mitigating the obesity epidemic and its metabolic sequelae. The ongoing study will provide essential insights into the efficacy of these energy restriction approaches across varied racial/ethnic backgrounds, addressing an urgent need in nutrition and metabolic health research. Registered Trial, National Institutes of Health, ClinicalTrials.gov (NCT05132686). Full article
(This article belongs to the Special Issue Intermittent Fasting on Human Health and Disease)
Show Figures

Figure 1

10 pages, 579 KiB  
Review
Unveiling Potential JAK Inhibitors in Inflammatory Disorders of the Gastrointestinal Tract
by Shahed Kamal, Sheng Wei Lo, Samantha McCall, Beverly Rodrigues, Andrew H. Tsoi and Jonathan P. Segal
Biologics 2024, 4(2), 177-186; https://doi.org/10.3390/biologics4020012 (registering DOI) - 14 May 2024
Abstract
Background: Janus kinase (JAK) inhibitors represent a novel class of oral therapies showing efficacy in treating ulcerative colitis (UC) and Crohn’s disease (CD), challenging conventional treatment paradigms. Summary: This review provides an overview of the potential novel uses of JAK inhibitors, focusing on [...] Read more.
Background: Janus kinase (JAK) inhibitors represent a novel class of oral therapies showing efficacy in treating ulcerative colitis (UC) and Crohn’s disease (CD), challenging conventional treatment paradigms. Summary: This review provides an overview of the potential novel uses of JAK inhibitors, focusing on their current approved indications and exploring possibilities beyond these indications. Tofacitinib and filgotinib are approved for UC, while upadacitinib is approved for both UC and CD. Additionally, their potential in acute severe UC, as steroid alternatives, and in managing fistulizing CD or extraintestinal manifestations are discussed. Key Message: JAK inhibitors play an important role in IBD (inflammatory bowel disease) treatment; however, clinicians must balance their promising efficacy with safety concerns. Individualized care and vigilance are essential for optimizing therapeutic benefits while mitigating potential adverse effects. Further research is necessary to clarify their efficacy, safety, and potential applications. Full article
Show Figures

Figure 1

8 pages, 1266 KiB  
Case Report
An Unusual Case of Cardiac Mass: A Multimodal Approach in Diagnosis and Treatment
by Ljiljana Rankovic-Nicic, Milica Dragicevic-Antonic, Zelimir Antonic, Vladimir Mihajlovic, Masa Petrovic, Tjasa Ivosevic, Gordana Stamenkovic, Svetislav Pelemis and Milovan Bojic
Healthcare 2024, 12(10), 1009; https://doi.org/10.3390/healthcare12101009 (registering DOI) - 14 May 2024
Abstract
Diagnosing intracardiac masses poses a complex, multimodal challenge. We present the case of a 72-year-old woman with a history of rheumatic fever leading to mitral stenosis and a previous mitral valve commissurotomy who reported fatigue, weakness, and palpitations over the past three months. [...] Read more.
Diagnosing intracardiac masses poses a complex, multimodal challenge. We present the case of a 72-year-old woman with a history of rheumatic fever leading to mitral stenosis and a previous mitral valve commissurotomy who reported fatigue, weakness, and palpitations over the past three months. Echocardiography revealed a tumor (53 × 40 mm) in the enlarged left atrium, attached by a wide base to the left atrium wall, exhibiting variable densities. Computerized tomography identified a heterodense mass (53 × 46 × 37 mm) with similar attachments. Angiography showed two branches from the circumflex artery intricately associated with the mass. Despite unsuccessful embolization of the mass’ blood supply, surgical intervention including mitral valve replacement, tricuspid valve annuloplasty, and tumor removal was pursued. Pathohistological analysis confirmed the mass as a thrombus. During the postoperative follow-up, the patient presented with no complaints. Follow-up echocardiography indicated the normal function of the mechanical mitral valve prosthesis and the absence of intracardiac masses. While it remains unknown whether this neovascularization is specific to patients with severe mitral valve disease, this case highlights the diagnostic challenges of differentiating between thrombi and tumors in the context of mitral valve disease. It illustrates the critical role of multimodal imaging in elucidating the anatomical and functional relationships within the heart, thereby guiding accurate diagnosis and effective treatment. Full article
Show Figures

Figure 1

22 pages, 11821 KiB  
Article
Bending Properties of Cold-Formed Thin-Walled Steel/Fast-Growing Timber Composite I-Beams
by Tianshu Chen, Zhihua Chen, Jiadi Liu and Anling Zhang
Forests 2024, 15(5), 857; https://doi.org/10.3390/f15050857 (registering DOI) - 14 May 2024
Abstract
A cold-formed, thin-walled steel/fast-growing timber composite system has recently been presented for low-rise buildings. It aims to increase the use of fast-growing wood as a green building material in structures, thus contributing to the transformation of traditional buildings. This study proposed a composite [...] Read more.
A cold-formed, thin-walled steel/fast-growing timber composite system has recently been presented for low-rise buildings. It aims to increase the use of fast-growing wood as a green building material in structures, thus contributing to the transformation of traditional buildings. This study proposed a composite I-beam combined with fast-growing radiata pine and cold-formed thin-walled U-shaped steel. A four-point bending test was used to measure the bending properties of steel–timber composite I-beams under various connection methods. Based on experimental results, this study examined the specimen’s failure mechanism, mechanical properties, and strain development. In addition, a method for calculating flexural bearing capacity based on the superposition principle and transformed section method was suggested. It is evident from the results that fast-growing timber and cold-formed thin-walled steel can have significant composite effects. Different connecting methods significantly impact beams’ failure mode, stiffness, and bearing capacity. Furthermore, the theoretical method for calculating the flexural bearing capacity of composite beams differs from the test value by less than 10%. This paper’s research encourages the applications of fast-growing wood as light residential components, and it serves as a reference for the development, production, and engineering of steel–timber composite structural systems. Full article
(This article belongs to the Section Wood Science and Forest Products)
Show Figures

Figure 1

27 pages, 2202 KiB  
Article
Tides of Blockchain in IoT Cybersecurity
by Love Allen Chijioke Ahakonye, Cosmas Ifeanyi Nwakanma and Dong-Seong Kim
Sensors 2024, 24(10), 3111; https://doi.org/10.3390/s24103111 (registering DOI) - 14 May 2024
Abstract
This paper surveys the implementation of blockchain technology in cybersecurity in Internet of Things (IoT) networks, presenting a comprehensive framework that integrates blockchain technology with intrusion detection systems (IDS) to enhance IDS performance. This paper reviews articles from various domains, including AI, blockchain, [...] Read more.
This paper surveys the implementation of blockchain technology in cybersecurity in Internet of Things (IoT) networks, presenting a comprehensive framework that integrates blockchain technology with intrusion detection systems (IDS) to enhance IDS performance. This paper reviews articles from various domains, including AI, blockchain, IDS, IoT, and Industrial IoT (IIoT), to identify emerging trends and challenges in this field. An analysis of various approaches incorporating AI and blockchain demonstrates the potentiality of integrating AI and blockchain to transform IDS. This paper’s structure establishes the foundation for further investigation and provides a blueprint for the development of IDS that is accessible, scalable, transparent, immutable, and decentralized. A demonstration from case studies integrating AI and blockchain shows the viability of combining the duo to enhance performance. Despite the challenges posed by resource constraints and privacy concerns, it is notable that blockchain is the key to securing IoT networks and that continued innovation in this area is necessary. Further research into lightweight cryptography, efficient consensus mechanisms, and privacy-preserving techniques is needed to realize all of the potential of blockchain-powered cybersecurity in IoT. Full article
(This article belongs to the Special Issue IoT Network Security)
Show Figures

Figure 1

20 pages, 4836 KiB  
Article
Spatiotemporal Effects and Optimization Strategies of Land-Use Carbon Emissions at the County Scale: A Case Study of Shaanxi Province, China
by Yahui Zhang, Jianfeng Li, Siqi Liu and Jizhe Zhou
Sustainability 2024, 16(10), 4104; https://doi.org/10.3390/su16104104 (registering DOI) - 14 May 2024
Abstract
Land use, as one of the major sources of carbon emissions, has profound implications for global climate change. County-level land-use systems play a critical role in national carbon emission management and control. Consequently, it is essential to explore the spatiotemporal effects and optimization [...] Read more.
Land use, as one of the major sources of carbon emissions, has profound implications for global climate change. County-level land-use systems play a critical role in national carbon emission management and control. Consequently, it is essential to explore the spatiotemporal effects and optimization strategies of land-use carbon emissions at the county scale to promote the achievement of regional dual carbon targets. This study, focusing on Shaanxi Province, analyzed the spatiotemporal characteristics of land use from 2000 to 2020. By establishing a carbon emission evaluation model, the spatiotemporal effects of county-level carbon emissions were clarified. Utilizing Geodetector and K-means clustering methods, the driving mechanisms and clustering characteristics of county-level carbon emissions were elucidated, and optimization strategies for land use carbon emission were explored. The results showed that during 2000–2020, land use in Shaanxi Province underwent significant spatiotemporal changes, with constructed land increasing by 97.62%, while cultivated land and grassland were substantially reduced. The overall county-level carbon emissions exhibited a pattern of North > Central > South. The total carbon emissions within the province increased nearly fourfold over 20 years, reaching 1.00 × 108 tons. Constructed land was the primary source of emissions, while forest land contributed significantly to the carbon sink of the study area. Interactions among factors had significant impacts on the spatial differentiation of total county-level carbon emissions. For counties with different types of carbon emissions, differentiated optimization strategies were recommended. Low-carbon emission counties should intensify ecological protection and rational utilization, medium-carbon emission counties need to strike a balance between economic development and environmental protection, while high-carbon emission counties should prioritize profound emission reduction and structural transformation. Full article
(This article belongs to the Topic Energy Economics and Sustainable Development)
Show Figures

Figure 1

23 pages, 3000 KiB  
Article
Comparative Study of Microwave, Pulsed Electric Fields, and High Pressure Processing on the Extraction of Antioxidants from Olive Pomace
by Maria Tsevdou, Athina Ntzimani, Maria Katsouli, George Dimopoulos, Dimitrios Tsimogiannis and Petros Taoukis
Molecules 2024, 29(10), 2303; https://doi.org/10.3390/molecules29102303 (registering DOI) - 14 May 2024
Abstract
Olive oil production is characterized by large amounts of waste, and yet is considerably highly valued. Olive pomace can serve as a cheap source of bioactive compounds (BACs) with important antioxidant activity. Novel technologies like Pulsed Electric Fields (PEF) and High Pressure (HP) [...] Read more.
Olive oil production is characterized by large amounts of waste, and yet is considerably highly valued. Olive pomace can serve as a cheap source of bioactive compounds (BACs) with important antioxidant activity. Novel technologies like Pulsed Electric Fields (PEF) and High Pressure (HP) and microwave (MW) processing are considered green alternatives for the recovery of BACs. Different microwave (150–600 W), PEF (1–5 kV/cm field strength, 100–1500 pulses/15 µs width), and HP (250–650 MPa) conditions, in various product/solvent ratios, methanol concentrations, extraction temperatures, and processing times were investigated. Results indicated that the optimal MW extraction conditions were 300 W at 50 °C for 5 min using 60% v/v methanol with a product/solvent ratio of 1:10 g/mL. Similarly, the mix of 40% v/v methanol with olive pomace, treated at 650 MPa for the time needed for pressure build-up (1 min) were considered as optimal extraction conditions in the case of HP, while for PEF the optimal conditions were 60% v/v methanol with a product/solvent ratio of 1:10 g/mL, treated at 5000 pulses, followed by 1 h extraction under stirring conditions. Therefore, these alternative extraction technologies could assist the conventional practice in minimizing waste production and simultaneously align with the requirements of the circular bioeconomy concept. Full article
Show Figures

Figure 1

14 pages, 276 KiB  
Article
Understanding the Complexities of Student Learning Progress in Texas: A Study of COVID-19 and Rural vs. Non-Rural Districts
by Shifang Tang, Zhuoying Wang, Lei Zhang and David Jimenez
Behav. Sci. 2024, 14(5), 408; https://doi.org/10.3390/bs14050408 (registering DOI) - 14 May 2024
Abstract
In this study, we investigate the impact of COVID-19 on academic achievement in Texas public schools. Demographic and Grade 5 STAAR test data were collected from 1155 public school districts for 2018–2019 and 2020–2021. Multiple regression was adopted to analyze the differences between [...] Read more.
In this study, we investigate the impact of COVID-19 on academic achievement in Texas public schools. Demographic and Grade 5 STAAR test data were collected from 1155 public school districts for 2018–2019 and 2020–2021. Multiple regression was adopted to analyze the differences between rural and non-rural districts, as well as the impact of demographic characteristics on students’ achievement. The results reveal significant differences in demographic characteristics between the two academic years, with non-rural districts exhibiting a greater decline in academic achievement than rural districts. Additionally, the findings suggest that higher teacher salaries correlate with better academic performance across various subjects and that English learners require additional support to acquire content knowledge and skills. We further confirm that the COVID-19 pandemic has disrupted the academic learning experience of Texas students, with rural districts displaying more resilience than non-rural districts. Full article
17 pages, 1139 KiB  
Article
Leisure-Time Physical Activity as a Pathway to Sustainable Living: Insights on Health, Environment, and Green Consumerism
by Han-Jen Niu, Kuei-Shu Huang, Pao-Yuan Huang and Huey-Fang Ju
Int. J. Environ. Res. Public Health 2024, 21(5), 618; https://doi.org/10.3390/ijerph21050618 (registering DOI) - 14 May 2024
Abstract
In the aftermath of the COVID-19 pandemic, the intricate relationship between health and the environment has emerged with unparalleled significance. This investigation examines the effect of leisure-time physical activity (LTPA) on health and environmental consciousness and its influence on attitudes towards green/sustainable products [...] Read more.
In the aftermath of the COVID-19 pandemic, the intricate relationship between health and the environment has emerged with unparalleled significance. This investigation examines the effect of leisure-time physical activity (LTPA) on health and environmental consciousness and its influence on attitudes towards green/sustainable products among 533 individuals. Utilizing linear structural modeling and regression analysis, the findings reveal that participation in sports and leisure activities significantly mediates the connection between individual well-being and eco-responsible consumer behaviors. Highlighting LTPA’s crucial role in enhancing environmental awareness, this study offers invaluable perspectives for the green product sector. It advocates for the development of strategies that align with consumers’ environmental values, underscoring the essential function of sports and leisure in fostering sustainable consumer practices. Crucially, this underscores the intertwined nature of environmental sustainability and individual health, highlighting their mutual dependence. Full article
(This article belongs to the Section Environmental Health)
Show Figures

Figure 1

27 pages, 12972 KiB  
Article
Characteristics and Genetic Mechanism of Granite Weathering Crust of Songnan Low Uplift, Qiongdongnan Basin, South China Sea
by Zhiyu Li, Jianhua Guo and Shiqing Wu
Minerals 2024, 14(5), 512; https://doi.org/10.3390/min14050512 (registering DOI) - 14 May 2024
Abstract
Recently, a large-scale gas reservoir was discovered in granitic buried hills of the Songnan Low Uplift in the Qiongdongnan Basin. However, the strong heterogeneity of granite reservoirs limits further exploration and evaluation. Based on observations of sixty core samples and sixty thin sections, [...] Read more.
Recently, a large-scale gas reservoir was discovered in granitic buried hills of the Songnan Low Uplift in the Qiongdongnan Basin. However, the strong heterogeneity of granite reservoirs limits further exploration and evaluation. Based on observations of sixty core samples and sixty thin sections, mineral composition, zircon dating, apatite fission tracks, physical properties, image logs, outcrop surveys and seismic interpretations, the characteristics of granite weathering crust of the Songnan Low Uplift are analyzed, and its controlling factors and evolution process are evaluated. The results show that weathered granite in the study area can be divided into several zones, from top to bottom: eluvium–slope zone, sandy zone, weathered fracture zone and horizontal undercurrent vuggy zone. The reservoirs in the eluvium–slope zone are dominated by microfissures and intergranular dissolution pores and have an average porosity of 4.68% and permeability of 2.34 md; the reservoirs in the sandy zone are composed of intergranular and intragranular dissolution pores and have an average porosity of 11.46% and permeability of 4.99 md; the reservoirs in the weathered fracture zone consist of various fractures and have an average porosity of 3.91% and permeability of 2.5 md; the reservoirs in the horizontal undercurrent vuggy zone are subhorizontal fractures and vugs and have an average porosity of 2.7% and permeability of 0.23 md. The development of granite reservoirs is jointly influenced by petrology and minerals, long-term exposure in a warm humid paleoclimate, faults, diverse topographies and shallow buried depth. Based on the above, our study establishes a development model of weathering crust and suggests that only the gentle slope and platform remain strongly weathered zones. After undergoing a complex evolution process of formation–destruction/denudation–regeneration–preservation, the current weathering crust of the Songnan Low Uplift is finally established. The results of this study have important theoretical and application value for the hydrocarbon exploration of buried hills in the Qiongdongnan Basin and provide a reference example for other granite reservoirs worldwide. Full article
(This article belongs to the Section Mineral Deposits)
Show Figures

Figure 1

14 pages, 551 KiB  
Article
Enriching Language Models with Graph-Based Context Information to Better Understand Textual Data
by Albert Roethel, Maria Ganzha and Anna Wróblewska
Electronics 2024, 13(10), 1919; https://doi.org/10.3390/electronics13101919 (registering DOI) - 14 May 2024
Abstract
A considerable number of texts encountered daily are somehow connected. For example, Wikipedia articles refer to other articles via hyperlinks, or scientific papers relate to others via citations or (co)authors; tweets relate via users that follow each other or reshare content. Hence, a [...] Read more.
A considerable number of texts encountered daily are somehow connected. For example, Wikipedia articles refer to other articles via hyperlinks, or scientific papers relate to others via citations or (co)authors; tweets relate via users that follow each other or reshare content. Hence, a graph-like structure can represent existing connections and be seen as capturing the “context” of the texts. The question thus arises of whether extracting and integrating such context information into a language model might help facilitate a better-automated understanding of the text. In this study, we experimentally demonstrate that incorporating graph-based contextualization into the BERT model enhances its performance on an example of a classification task. Specifically, in the Pubmed dataset, we observed a reduction in balanced mean error from 8.51% to 7.96%, while increasing the number of parameters just by 1.6%. Full article
(This article belongs to the Special Issue Advances in Graph-Based Data Mining)
Show Figures

Figure 1

16 pages, 7539 KiB  
Article
Sparse Clustering Algorithm Based on Multi-Domain Dimensionality Reduction Autoencoder
by Yu Kang, Erwei Liu, Kaichi Zou, Xiuyun Wang and Huaqing Zhang
Mathematics 2024, 12(10), 1526; https://doi.org/10.3390/math12101526 (registering DOI) - 14 May 2024
Abstract
The key to high-dimensional clustering lies in discovering the intrinsic structures and patterns in data to provide valuable information. However, high-dimensional clustering faces enormous challenges such as dimensionality disaster, increased data sparsity, and reduced reliability of the clustering results. In order to address [...] Read more.
The key to high-dimensional clustering lies in discovering the intrinsic structures and patterns in data to provide valuable information. However, high-dimensional clustering faces enormous challenges such as dimensionality disaster, increased data sparsity, and reduced reliability of the clustering results. In order to address these issues, we propose a sparse clustering algorithm based on a multi-domain dimensionality reduction model. This method achieves high-dimensional clustering by integrating the sparse reconstruction process and sparse L1 regularization into a deep autoencoder model. A sparse reconstruction module is designed based on the L1 sparse reconstruction of features under different domains to reconstruct the data. The proposed method mainly contributes in two aspects. Firstly, the spatial and frequency domains are combined by taking into account the spatial distribution and frequency characteristics of the data to provide multiple perspectives and choices for data analysis and processing. Then, a neural network-based clustering model with sparsity is conducted by projecting data points onto multi-domains and implementing adaptive regularization penalty terms to the weight matrix. The experimental results demonstrate superior performance of the proposed method in handling clustering problems on high-dimensional datasets. Full article
Show Figures

Figure 1

12 pages, 3866 KiB  
Article
Synergetic Catalytic Effect between Ni and Co in Bimetallic Phosphide Boosting Hydrogen Evolution Reaction
by Xiaohan Wang, Han Tian, Libo Zhu, Shujing Li and Xiangzhi Cui
Nanomaterials 2024, 14(10), 853; https://doi.org/10.3390/nano14100853 (registering DOI) - 14 May 2024
Abstract
The application of electrochemical hydrogen evolution reaction (HER) for renewable energy conversion contributes to the ultimate goal of a zero-carbon emission society. Metal phosphides have been considered as promising HER catalysts in the alkaline environment, which, unfortunately, is still limited owing to the [...] Read more.
The application of electrochemical hydrogen evolution reaction (HER) for renewable energy conversion contributes to the ultimate goal of a zero-carbon emission society. Metal phosphides have been considered as promising HER catalysts in the alkaline environment, which, unfortunately, is still limited owing to the weak adsorption of H* and easy dissolution during operation. Herein, a bimetallic NiCoP-2/NF phosphide is constructed on nickel foam (NF), requiring rather low overpotentials of 150 mV and 169 mV to meet the current densities of 500 and 1000 mA cm−2, respectively, and able to operate stably for 100 h without detectable activity decay. The excellent HER performance is obtained thanks to the synergetic catalytic effect between Ni and Co, among which Ni is introduced to enhance the intrinsic activity and Co increases the electrochemically active area. Meanwhile, the protection of the externally generated amorphous phosphorus oxide layer improves the stability of NiCoP/NF. An electrolyser using NiCoP-2/NF as both cathode and anode catalysts in an alkaline solution can produce hydrogen with low electric consumption (overpotential of 270 mV at 500 mA cm−2). Full article
Show Figures

Figure 1

28 pages, 10784 KiB  
Article
Implementation of a Universal Framework Using Design Patterns for Application Development on Microcontrollers
by Marek Babiuch and Petr Foltynek
Sensors 2024, 24(10), 3116; https://doi.org/10.3390/s24103116 (registering DOI) - 14 May 2024
Abstract
This article focuses on the area of software development for microcontrollers and details the implementation of modern programming practices and principles in embedded systems and IoT applications. This article explains how we implemented previously unimplemented principles and applied design patterns for quality software [...] Read more.
This article focuses on the area of software development for microcontrollers and details the implementation of modern programming practices and principles in embedded systems and IoT applications. This article explains how we implemented previously unimplemented principles and applied design patterns for quality software design on microcontrollers, which are currently only used for developing applications on the higher layers of the IoT reference model. A custom modular framework for microcontrollers is presented, based on applying SOLID principles and adapting design patterns specific to the microcontrollers’ application development needs. The implemented framework enables independent communication between modules and flexible integration of hardware components. It is designed with platform independence in mind, contributing to its wide adaptability and ease of use in diverse development environments. By applying these technological approaches, we can create applications that are not only testable and extensible in terms of application logic but also allow for easy adaptation to changes in these hardware resources. Utilizing these capabilities represents an innovative approach to development for microcontrollers that fundamentally improves the long-term sustainability and scalability of applications. Full article
(This article belongs to the Section Internet of Things)
Show Figures

Figure 1

16 pages, 1214 KiB  
Review
Global Distribution and Molecular Evolution of Bat Coronaviruses
by Mohamed El Sayes, Rebecca Badra, Mohamed A. Ali, Rabeh El-Shesheny and Ghazi Kayali
Zoonotic Dis. 2024, 4(2), 146-161; https://doi.org/10.3390/zoonoticdis4020014 (registering DOI) - 14 May 2024
Abstract
Bat coronaviruses cause a wide range of illnesses in humans and animals. Bats are known to harbor a wide diversity of Alphacoronaviruses and Betacoronaviruses. Betacoronaviruses have been linked to Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS), and other diseases such [...] Read more.
Bat coronaviruses cause a wide range of illnesses in humans and animals. Bats are known to harbor a wide diversity of Alphacoronaviruses and Betacoronaviruses. Betacoronaviruses have been linked to Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS), and other diseases such as gastroenteritis, bronchiolitis, and pneumonia. In the last 20 years, three betacoronaviruses emerged and caused widespread outbreaks in humans, including two deadly betacoronavirus epidemics, SARS-CoV, with mortality rate of 10%, and MERS-CoV, with mortality rate of 34.7%, and SARS-CoV-2, which caused the COVID-19 pandemic, with mortality rate of 3.4%. Studies have shown that bats are the main natural reservoirs for these viruses or their ancestral viruses. Observed variations in bat coronavirus genomes indicate that these viruses may have a potential to transmit to other hosts in close contact with humans and subsequently transmit to humans. As of today, there are no reported cases of direct coronavirus transmission from bats to humans. One reason for this might be that intermediate hosts are required for the transmission of bat coronaviruses to humans. Further studies are needed to map the amino acids and genomic regions responsible for the interactions between the spike of coronavirus and its receptors. Full article
Show Figures

Figure 1

16 pages, 4779 KiB  
Article
Genome-Wide Identification and Characterization of the GRAS Gene Family in Lettuce Revealed That Silencing LsGRAS13 Delayed Bolting
by Li Chen, Yong Qin and Shuangxi Fan
Plants 2024, 13(10), 1360; https://doi.org/10.3390/plants13101360 (registering DOI) - 14 May 2024
Abstract
Lettuce is susceptible to high-temperature stress during cultivation, leading to bolting and affecting yield. Plant-specific transcription factors, known as GRAS proteins, play a crucial role in regulating plant growth, development, and abiotic stress responses. In this study, the entire lettuce LsGRAS gene family [...] Read more.
Lettuce is susceptible to high-temperature stress during cultivation, leading to bolting and affecting yield. Plant-specific transcription factors, known as GRAS proteins, play a crucial role in regulating plant growth, development, and abiotic stress responses. In this study, the entire lettuce LsGRAS gene family was identified. The results show that 59 LsGRAS genes are unevenly distributed across the nine chromosomes. Additionally, all LsGRAS proteins showed 100% nuclear localization based on the predicted subcellular localization and were phylogenetically classified into nine conserved subfamilies. To investigate the expression profiles of these genes in lettuce, we analyzed the transcription levels of all 59 LsGRAS genes in the publicly available RNA-seq data under the high-temperature treatment conducted in the presence of exogenous melatonin. The findings indicate that the transcript levels of the LsGRAS13 gene were higher on days 6, 9, 15, 18, and 27 under the high-temperature (35/30 °C) treatment with melatonin than on the same treatment days without melatonin. The functional studies demonstrate that silencing LsGRAS13 accelerated bolting in lettuce. Furthermore, the paraffin sectioning results showed that flower bud differentiation in LsGRAS13-silenced plants occurred significantly faster than in control plants. In this study, the LsGRAS genes were annotated and analyzed, and the expression pattern of the LsGRAS gene following melatonin treatment under high-temperature conditions was explored. This exploration provides valuable information and identifies candidate genes associated with the response mechanism of lettuce plants high-temperature stress. Full article
(This article belongs to the Special Issue The Growth and Development of Vegetable Crops)
Show Figures

Figure 1

13 pages, 3348 KiB  
Article
Wireless Underground Sensor Communication Using Acoustic Technology
by Md Adnan Al Moshi, Marcus Hardie, Tanveer Choudhury and Joarder Kamruzzaman
Sensors 2024, 24(10), 3113; https://doi.org/10.3390/s24103113 (registering DOI) - 14 May 2024
Abstract
The rapid advancement toward smart cities has accelerated the adoption of various Internet of Things (IoT) devices for underground applications, including agriculture, which aims to enhance sustainability by reducing the use of vital resources such as water and maximizing production. On-farm IoT devices [...] Read more.
The rapid advancement toward smart cities has accelerated the adoption of various Internet of Things (IoT) devices for underground applications, including agriculture, which aims to enhance sustainability by reducing the use of vital resources such as water and maximizing production. On-farm IoT devices with above-ground wireless nodes are vulnerable to damage and data loss due to heavy machinery movement, animal grazing, and pests. To mitigate these risks, wireless Underground Sensor Networks (WUSNs) are proposed, where devices are buried underground. However, implementing WUSNs faces challenges due to soil heterogeneity and the need for low-power, small-size, and long-range communication technology. While existing radio frequency (RF)-based solutions are impeded by substantial signal attenuation and low coverage, acoustic wave-based WUSNs have the potential to overcome these impediments. This paper is the first attempt to review acoustic propagation models to discern a suitable model for the advancement of acoustic WUSNs tailored to the agricultural context. Our findings indicate the Kelvin–Voigt model as a suitable framework for estimating signal attenuation, which has been verified through alignment with documented outcomes from experimental studies conducted in agricultural settings. By leveraging data from various soil types, this research underscores the feasibility of acoustic signal-based WUSNs. Full article
Show Figures

Figure 1

12 pages, 5129 KiB  
Article
Association between Obesity and Atrial Function in Patients with Non-Valvular Atrial Fibrillation: An Echocardiographic Study
by Martina Pucci, Vittoria Gammaldi, Luca Maria Capece, Daniele Paoletta, Adelaide Iervolino, Mariateresa Pontoriero, Marina Iacono, Pasquale Megaro and Roberta Esposito
J. Clin. Med. 2024, 13(10), 2895; https://doi.org/10.3390/jcm13102895 (registering DOI) - 14 May 2024
Abstract
Background: Obesity is a public health problem which prevalence has increased worldwide and is associated with different degrees of hemodynamic alterations and structural cardiac changes. The aim of the study is to investigate the impact of body mass index (BMI) on left atrial [...] Read more.
Background: Obesity is a public health problem which prevalence has increased worldwide and is associated with different degrees of hemodynamic alterations and structural cardiac changes. The aim of the study is to investigate the impact of body mass index (BMI) on left atrial function using standard and advanced echocardiography in a population of patients with non-valvular atrial fibrillation (AF). Methods: 395 adult patients suffering from non-valvular AF, divided into three tertiles based on BMI value, carry out a cardiological examination with standard and advanced echocardiography. Results: Peak atrial longitudinal strain (PALS), a measure of left atrial function, is lower in the tertile with highest BMI (14.3 ± 8.2%) compared to both the first (19 ± 11.5%) and the second tertile (17.7 ± 10.6%) in a statistically significant manner (p < 0.002). Furthermore, BMI is significantly associated independent with the PALS by multilinear regression analysis, even after correction of the data for CHA2DS2-VASc score, left ventricular mass index, left ventricular ejection fraction, E/E’ ratio and systolic pulmonary arterial pressure (coefficient standardized β = −0.127, p < 0.02; Cumulative R2 = 0.41, SEE = 0.8%, p < 0.0001). Conclusions: BMI could be considered an additional factor in assessing cardiovascular risk in patients with non-valvular atrial fibrillation, in addition to the well-known CHA2DS2-VASc score. Full article
(This article belongs to the Special Issue Advances in Clinical Application of Echocardiography: Volume II)
Show Figures

Figure 1

17 pages, 8176 KiB  
Article
Effect of Phosphate-Deficiency Stress on the Biological Characteristics and Transcriptomics of Panax ginseng
by Hai Sun, Hao Liang, Cai Shao, Jiaqi Qian, Jiapeng Zhu, Guojia Zhang, Bochen Lv and Yayu Zhang
Horticulturae 2024, 10(5), 506; https://doi.org/10.3390/horticulturae10050506 (registering DOI) - 14 May 2024
Abstract
The low availability of phosphorus has become a common problem worldwide. Phosphorus is essential for phenotypic morphology and ginsenoside synthesis. However, the effects of Pi stress on ginseng phenotype and ginsenoside synthesis remain unclear. Phenotypic analyses and transcriptomics revealed the phenotypic construction and [...] Read more.
The low availability of phosphorus has become a common problem worldwide. Phosphorus is essential for phenotypic morphology and ginsenoside synthesis. However, the effects of Pi stress on ginseng phenotype and ginsenoside synthesis remain unclear. Phenotypic analyses and transcriptomics revealed the phenotypic construction and regulation of differential genes involved in the physiological metabolism of ginseng under low-Pi stress. Root length and stem length were found to be significantly inhibited by phosphate-deficiency stress in the half-phosphate (HP) and no-phosphate (NP) treatment groups; however, the number of fibrous roots, which are regulated by phytohormones, was found to increase. In ginseng leaves, the indexes of physiological stress, superoxide anion (221.19 nmol/g) and malonaldehyde (MDA) (0.05 μmol/min/g), reached the maximum level. Moreover, chlorophyll fluorescence images and chlorophyll content further confirmed the inhibition of ginseng photosynthesis under low-Pi stress. A total of 579 and 210 differentially expressed genes (DEGs) were shared between NP and total phosphate (TP) and HP and TP, respectively, and only 64 common DEGs were found based on the two comparisons. These DEGs were mainly related to the synthesis of phosphate transporters (PHTs), phytohormones, and ginsenosides. According to KEGG analyses, four DEGs (Pg_s 0368.2, Pg_s3418.1, Pg_s5392.5 and Pg_s3342.1) affected acetyl-CoA production by regulating glycometabolism and tricarboxylic acid cycle (TCA). In addition, related genes, including those encoding 13 PHTs, 15 phytohormones, and 20 ginsenoside synthetases, were screened in ginseng roots under Pi-deficiency stress. These results indicate that changes in the ginseng phenotype and transcriptional regulation of DEGs are involved in the Pi-deficiency stress environment of ginseng, thereby providing new information regarding the development of ginseng for low-Pi tolerance. Full article
Show Figures

Figure 1

20 pages, 6579 KiB  
Article
The Bolt Anchorage Performance of Fractured Rock under a Freeze–Thaw Cycle Load
by Fengyan Han and Yu Chen
Appl. Sci. 2024, 14(10), 4152; https://doi.org/10.3390/app14104152 (registering DOI) - 14 May 2024
Abstract
In circumstances influenced by freeze–thaw cycles, the strength of rock diminishes, necessitating an in-depth investigation into its corresponding anchoring support schemes. This study conducted experiments on rocks with and without fractures at angles of 0°, 45°, and 90° subjected to freeze–thaw cycles of [...] Read more.
In circumstances influenced by freeze–thaw cycles, the strength of rock diminishes, necessitating an in-depth investigation into its corresponding anchoring support schemes. This study conducted experiments on rocks with and without fractures at angles of 0°, 45°, and 90° subjected to freeze–thaw cycles of 0, 10, 20, and 30 iterations. It explored the effects of fracture inclination, anchoring conditions, and freeze–thaw cycles on the mechanical properties of rock. The primary findings from the experiments are as follows: (1) fracture inclination significantly impacts rock strength, with the most pronounced deterioration observed in samples with a 45° fracture, exhibiting strengths and elastic moduli at 28.4% and 73.4%, respectively, of those of fracture-free samples; (2) anchoring effectively controls deformation but concurrently induces stress concentrations, resulting in Y-shaped crack formation around the anchoring rod; (3) the degree of strength reduction due to freeze–thaw cycles is angle-dependent, with fracture-free and 90° fracture samples exhibiting diminished strength post freezing, while the 45° fracture samples’ strength remains largely unchanged. Additionally, this study employed a numerical model, coupling a discrete element method (DEM) with a finite difference method (FDM), to simulate experimental conditions, yielding conclusions consistent with experimental outcomes, and notably revealing a prevalence of tensile cracks over shear cracks within samples under uniaxial compression. Full article
(This article belongs to the Special Issue Recent Research on Tunneling and Underground Engineering)
Show Figures

Figure 1

19 pages, 10828 KiB  
Article
Intelligent Diagnosis of Concrete Defects Based on Improved Mask R-CNN
by Caiping Huang, Yongkang Zhou and Xin Xie
Appl. Sci. 2024, 14(10), 4148; https://doi.org/10.3390/app14104148 (registering DOI) - 14 May 2024
Abstract
With the rapid development of artificial intelligence, computer vision techniques have been successfully applied to concrete defect diagnosis in bridge structural health monitoring. To enhance the accuracy of identifying the location and type of concrete defects (cracks, exposed bars, spalling, efflorescence and voids), [...] Read more.
With the rapid development of artificial intelligence, computer vision techniques have been successfully applied to concrete defect diagnosis in bridge structural health monitoring. To enhance the accuracy of identifying the location and type of concrete defects (cracks, exposed bars, spalling, efflorescence and voids), this paper proposes improvements to the existing Mask Region Convolution Neural Network (Mask R-CNN). The improvements are as follows: (i) The residual network (ResNet101), the backbone network of Mask R-CNN which has too many convolution layers, is replaced by the lightweight network MobileNetV2. This can solve the problem that the large number of parameters leads to a slow training speed of the model, and improve the ability to extract features of smaller targets. (ii) Embedding attention mechanism modules in Feature Pyramid Networks (FPNs) to better extract the target features. (iii) A path aggregation network (PANet) is added to solve the problem that the model Mask R-CNN lacks the ability to extract shallow layer feature information. To validate the superiority of the proposed improved Mask R-CNN, the multi-class concrete defect image dataset was constructed, and using the K-means clustering algorithm to determine the aspect ratio of the most suitable prior bounding box for the dataset. Following, the identification results of improved Mask-RCNN, original Mask-RCNN and other mainstream deep learning networks on five types of concrete defects (cracks, exposed bars, spalling, efflorescence and voids) in the dataset were compared. Finally, the intelligent identification system for concrete defects has been established by innovatively combining images taken by unmanned aerial vehicles (UAVs) with our improved defect identification model. The reinforced concrete bridge defects images collected by UAVs were used as test set for testing. The result is the improved Mask R-CNN with superior accuracy, and the identification accuracy is higher than the original Mask-RCNN and other deep learning networks. The improved Mask-RCNN can identify the new untrained concrete defects images taken by UAVs, and the identification accuracy can meet the requirements of bridge structural health monitoring. Full article
(This article belongs to the Section Civil Engineering)
Show Figures

Figure 1

Open Access Journals

Browse by Indexing Browse by Subject Selected Journals
Back to TopTop