The 2023 MDPI Annual Report has
been released!
 
13 pages, 643 KiB  
Article
Good Health-Related Quality of Life in Older Patients One Year after mTBI despite Incomplete Recovery: An Indication of the Disability Paradox?
by Sophie M. Coffeng, Amaal Eman Abdulle, Harm J. van der Horn, Myrthe E. de Koning, Jan C. ter Maaten, Jacoba M. Spikman and Joukje van der Naalt
J. Clin. Med. 2024, 13(9), 2655; https://doi.org/10.3390/jcm13092655 (registering DOI) - 01 May 2024
Abstract
Background: Older adults (OAs) with mild traumatic brain injury (OA-mTBI) are a growing population, but studies on long-term outcomes and quality of life are scarce. Our aim was to determine the health-related quality of life (HRQoL) in OA-mTBI one year after injury [...] Read more.
Background: Older adults (OAs) with mild traumatic brain injury (OA-mTBI) are a growing population, but studies on long-term outcomes and quality of life are scarce. Our aim was to determine the health-related quality of life (HRQoL) in OA-mTBI one year after injury and to assess the early predictors of HRQoL. Methods: Data from a prospective follow-up study of 164 older (≥60 years) and 289 younger mTBI patients (<60 years) admitted to the emergency department were analyzed. Post-traumatic complaints, emotional distress and coping were evaluated 2 weeks post-injury using standardized questionnaires. At 12 months post-injury, HRQoL and functional recovery were determined with the abbreviated version of the World Health Organization Quality of Life scale and Glasgow Outcome Scale Extended (GOSE), respectively. Results: One year post-injury, 80% (n = 131) of the OA-mTBI rated their HRQoL as “good” or “very good”, which was comparable to younger patients (79% (n = 226), p = 0.72). Incomplete recovery (GOSE <8) was present in 43% (n = 69) of OA-mTBI, with 67% (n = 46) reporting good HRQoL. Two weeks post-injury, fewer OA-mTBI had (≥2) post-traumatic complaints compared to younger patients (68% vs. 80%, p = 0.01). In the multivariable analyses, only depression-related symptoms (OR = 1.20 for each symptom, 95% CI = 1.01–1.34, p < 0.01) were predictors of poor HRQoL in OA-mTBI. Conclusions: Similar to younger patients, most OA-mTBI rated their HRQoL as good at one year after injury, although a considerable proportion showed incomplete recovery according to the GOSE, suggesting a disability paradox. Depression-related symptoms emerged as a significant predictor for poor HRQoL and can be identified as an early target for treatment after mTBI. Full article
(This article belongs to the Special Issue Clinical Advances in Traumatic Brain Injury)
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17 pages, 321 KiB  
Article
Learning with Online Teaching Video Cases: Investigating Pre-Service Preschool Teachers’ Perceived Usefulness and Needs
by Rongrong Xu, Alfredo Bautista and Weipeng Yang
Educ. Sci. 2024, 14(5), 479; https://doi.org/10.3390/educsci14050479 (registering DOI) - 01 May 2024
Abstract
Extensive empirical research has emphasized the benefits of integrating Online Teaching Video Cases (OTVCs) into pre-service preschool teacher education. However, there is a research gap concerning the perceptions and needs of pre-service preschool teachers regarding OTVCs. This cross-sectional study, therefore, investigated pre-service preschool [...] Read more.
Extensive empirical research has emphasized the benefits of integrating Online Teaching Video Cases (OTVCs) into pre-service preschool teacher education. However, there is a research gap concerning the perceptions and needs of pre-service preschool teachers regarding OTVCs. This cross-sectional study, therefore, investigated pre-service preschool teachers’ perceptions of usefulness and need pertaining to OTVCs and examined potential differences across course year levels. A self-designed questionnaire survey was completed by 744 participants from the Shandong Province (China), with a focus on five domains: actors showcased in the OTVCs, OTVC-mediated activities, learning facilitators, situations requiring OTVCs, and areas for improvement. The results revealed that the participants identified expert teacher demonstrations and collaborative learning experiences with peers and instructors as the most useful types of OTVCs. They expressed the need for OTVCs to assist them with job preparation and a desire to learn content knowledge and engage with larger communities of preschool practitioners. Interestingly, the findings revealed significant differences among participants of different year levels, with Year 3 participants finding OTVCs more useful and necessary in most domains. These findings will help preschool teacher educators improve the responsiveness of OTVC-based instruction, thereby providing online video resources tailored to the preferences and needs of pre-service preschool teachers. Full article
32 pages, 7440 KiB  
Review
A Systematic Review of the Application of the Geostationary Ocean Color Imager to the Water Quality Monitoring of Inland and Coastal Waters
by Shidi Shao, Yu Wang, Ge Liu and Kaishan Song
Remote Sens. 2024, 16(9), 1623; https://doi.org/10.3390/rs16091623 (registering DOI) - 01 May 2024
Abstract
In recent decades, eutrophication in inland and coastal waters (ICWs) has increased due to anthropogenic activities and global warming, thus requiring timely monitoring. Compared with traditional sampling and laboratory analysis methods, satellite remote sensing technology can provide macro-scale, low-cost, and near real-time water [...] Read more.
In recent decades, eutrophication in inland and coastal waters (ICWs) has increased due to anthropogenic activities and global warming, thus requiring timely monitoring. Compared with traditional sampling and laboratory analysis methods, satellite remote sensing technology can provide macro-scale, low-cost, and near real-time water quality monitoring services. The Geostationary Ocean Color Imager (GOCI), aboard the Communication Ocean and Meteorological Satellite (COMS) from the Republic of Korea, marked a significant milestone as the world’s inaugural geostationary ocean color observation satellite. Its operational tenure spanned from 1 April 2011 to 31 March 2021. Over ten years, the GOCI has observed oceans, coastal waters, and inland waters within its 2500 km × 2500 km target area centered on the Korean Peninsula. The most attractive feature of the GOCI, compared with other commonly used water color sensors, was its high temporal resolution (1 h, eight times daily from 0 UTC to 7 UTC), providing an opportunity to monitor ICWs, where their water quality can undergo significant changes within a day. This study aims to comprehensively review GOCI features and applications in ICWs, analyzing progress in atmospheric correction algorithms and water quality monitoring. Analyzing 123 articles from the Web of Science and China National Knowledge Infrastructure (CNKI) through a bibliometric quantitative approach, we examined the GOCI’s strength and performance with different processing methods. These articles reveal that the GOCI played an essential role in monitoring the ecological health of ICWs in its observation coverage (2500 km × 2500 km) in East Asia. The GOCI has led the way to a new era of geostationary ocean satellites, providing new technical means for monitoring water quality in oceans, coastal zones, and inland lakes. We also discuss the challenges encountered by Geostationary Ocean Color Sensors in monitoring water quality and provide suggestions for future Geostationary Ocean Color Sensors to better monitor the ICWs. Full article
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13 pages, 1032 KiB  
Article
Multi-Electrode EMG Spatial-Filter Implementation Based on Current Conveyors
by Federico N. Guerrero, Valentín A. Catacora, Alfio Dario Grasso and Gaetano Palumbo
Electronics 2024, 13(9), 1735; https://doi.org/10.3390/electronics13091735 (registering DOI) - 01 May 2024
Abstract
In this work, a circuit topology for the implementation of a multi-electrode superficial electromyography (EMG) front-end is presented based on a type II current conveyor (CCII). The presented topology provides a feasible way to implement an amplifier capable of measuring several electrode locations [...] Read more.
In this work, a circuit topology for the implementation of a multi-electrode superficial electromyography (EMG) front-end is presented based on a type II current conveyor (CCII). The presented topology provides a feasible way to implement an amplifier capable of measuring several electrode locations and obtaining the signal of interest for posterior acquisition. In particular, a five-electrode normal double differential (NDD) EMG spatial filter is demonstrated. The signal modes necessary for the analysis of the circuit are derived, the respective rejection ratios are obtained, and the noise characteristic is calculated. A board-level electrode is implemented as a proof of concept, achieving a gain equal to 28 dB, a bandwidth of 17 Hz to 578 Hz, a noise voltage linked to the input of 3.7 μVrms and a common-mode rejection ratio higher than 95 dB at interference frequencies. The topology was validated after using it as an active electrode in experimental EMG measurements with an NDD dry-contact electrode in a flexible printed circuit board. Full article
(This article belongs to the Section Circuit and Signal Processing)
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22 pages, 3119 KiB  
Article
Dysregulation of a Subset of Circulating and Vesicle-Associated miRNA in Pancreatic Cancer
by Giulia Girolimetti, Iulia Andreea Pelisenco, Leonardo Henry Eusebi, Claudio Ricci, Beatrice Cavina, Ivana Kurelac, Tiziano Verri, Matteo Calcagnile, Pietro Alifano, Alessandro Salvi, Cecilia Bucci and Flora Guerra
Non-Coding RNA 2024, 10(3), 29; https://doi.org/10.3390/ncrna10030029 (registering DOI) - 01 May 2024
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive neoplasia, characterized by early metastasis, low diagnostic rates at early stages, resistance to drugs, and poor prognosis. There is an urgent need to better characterize this disease in order to identify efficient diagnostic/prognostic [...] Read more.
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive neoplasia, characterized by early metastasis, low diagnostic rates at early stages, resistance to drugs, and poor prognosis. There is an urgent need to better characterize this disease in order to identify efficient diagnostic/prognostic biomarkers. Since microRNAs (miRNAs) contribute to oncogenesis and metastasis formation in PDAC, they are considered potential candidates for fulfilling this task. In this work, the levels of two miRNA subsets (involved in chemoresistance or with oncogenic/tumor suppressing functions) were investigated in a panel of PDAC cell lines and liquid biopsies of a small cohort of patients. We used RT-qPCR and droplet digital PCR (ddPCR) to measure the amounts of cellular- and vesicle-associated, and circulating miRNAs. We found that both PDAC cell lines, also after gemcitabine treatment, and patients showed low amounts of cellular-and vesicle-associated miR-155-5p, compared to controls. Interestingly, we did not find any differences when we analyzed circulating miR-155-5p. Furthermore, vesicle-related miR-27a-3p increased in cancer patients compared to the controls, while circulating let-7a-5p, miR-221-3p, miR-23b-3p and miR-193a-3p presented as dysregulated in patients compared to healthy individuals. Our results highlight the potential clinical significance of these analyzed miRNAs as non-invasive diagnostic molecular tools to characterize PDAC. Full article
(This article belongs to the Special Issue Extracellular Vesicles and ncRNA)
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19 pages, 349 KiB  
Review
Natural Antimicrobials in Dairy Products: Benefits, Challenges, and Future Trends
by Maria Eduarda Marques Soutelino, Adriana Cristina de Oliveira Silva and Ramon da Silva Rocha
Antibiotics 2024, 13(5), 415; https://doi.org/10.3390/antibiotics13050415 (registering DOI) - 01 May 2024
Abstract
This review delves into using natural antimicrobials in the dairy industry and examines various sources of these compounds, including microbial, plant, and animal sources. It discusses the mechanisms by which they inhibit microbial growth, for example, by binding to the cell wall’s precursor [...] Read more.
This review delves into using natural antimicrobials in the dairy industry and examines various sources of these compounds, including microbial, plant, and animal sources. It discusses the mechanisms by which they inhibit microbial growth, for example, by binding to the cell wall’s precursor molecule of the target microorganism, consequently inhibiting its biosynthesis, and interfering in the molecule transport mechanism, leading to cell death. In general, they prove to be effective against the main pathogens and spoilage found in food, such as Escherichia coli, Staphylococcus aureus, Bacillus spp., Salmonella spp., mold, and yeast. Moreover, this review explores encapsulation technology as a promising approach for increasing the viability of natural antimicrobials against unfavorable conditions such as pH, temperature, and oxygen exposure. Finally, this review examines the benefits and challenges of using natural antimicrobials in dairy products. While natural antimicrobials offer several advantages, including improved safety, quality, and sensory properties of dairy products, it is crucial to be aware of the challenges associated with their use, such as potential allergenicity, regulatory requirements, and consumer perception. This review concludes by emphasizing the need for further research to identify and develop effective and safe natural antimicrobials for the dairy industry to ensure the quality and safety of dairy products for consumers. Full article
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18 pages, 3481 KiB  
Article
What Is the Future of Augmented Reality in Science Teaching and Learning? An Exploratory Study on Primary and Pre-School Teacher Students’ Views
by Giorgos Peikos and Angelos Sofianidis
Educ. Sci. 2024, 14(5), 480; https://doi.org/10.3390/educsci14050480 (registering DOI) - 01 May 2024
Abstract
While extensive research has explored the impact of Augmented Reality (AR) on student perspectives, experiences, and outcomes, there remains a significant gap in empirical studies focusing on teachers’ viewpoints, particularly within Science Education. Given that uncovering teachers’ viewpoints is crucial for leveraging AR [...] Read more.
While extensive research has explored the impact of Augmented Reality (AR) on student perspectives, experiences, and outcomes, there remains a significant gap in empirical studies focusing on teachers’ viewpoints, particularly within Science Education. Given that uncovering teachers’ viewpoints is crucial for leveraging AR technology’s potential in education since teachers decide whether to integrate it into their classrooms, the research question guiding this exploratory study is as follows: How do primary and pre-school teacher students perceive the integration of AR into Science teaching and learning following their engagement with pertinent university courses? Following a mixed-method approach, the data were collected via written questionnaires from 69 teacher students and focus group discussions involving 12 participants. Subsequent descriptive statistical and thematic analyses revealed that teacher students hold positive stances towards the integration of AR in Science Education. They emphasized that AR could significantly enhance motivational and cognitive outcomes for their future students while also improving accessibility and inclusion. Furthermore, their involvement in creating AR-enhanced materials not only increased course engagement and interest but also broadened their knowledge and fostered a sense of innovation, with the AR platform and application used being perceived as easy to use. Finally, challenges associated with classroom implementation were also highlighted. Full article
(This article belongs to the Special Issue Teaching and Learning with Virtual/Augmented Reality)
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3 pages, 153 KiB  
Editorial
Brain Sciences Special Issue “Neuromodulation of Cortical Networks in Neurological and Neuropsychiatric Disorders: Potential Clinical Indications and the Biophysiological Impact of Stimulation”
by Maja Rogić Vidaković, Joško Šoda and Joshua Elan Kuluva
Brain Sci. 2024, 14(5), 459; https://doi.org/10.3390/brainsci14050459 (registering DOI) - 01 May 2024
Abstract
Individuals with neurological and neuropsychiatric disorders face a variety of difficulties that can significantly impact their daily lives [...] Full article
25 pages, 3245 KiB  
Review
Application of Strain Selection Technology in Alcoholic Beverages: A Review
by Xiaodie Chen, Chuan Song, Jian Zhao, Zhuang Xiong, Lianxin Peng, Liang Zou, Caihong Shen and Qiang Li
Foods 2024, 13(9), 1396; https://doi.org/10.3390/foods13091396 (registering DOI) - 01 May 2024
Abstract
The diversity of alcohol beverage microorganisms is of great significance for improving the brewing process and the quality of alcohol beverage products. During the process of making alcoholic beverages, a group of microorganisms, represented by yeast and lactic acid bacteria, conducts fermentation. These [...] Read more.
The diversity of alcohol beverage microorganisms is of great significance for improving the brewing process and the quality of alcohol beverage products. During the process of making alcoholic beverages, a group of microorganisms, represented by yeast and lactic acid bacteria, conducts fermentation. These microorganisms have complex synergistic or competitive relationships, and the participation of different microorganisms has a major impact on the fermentation process and the flavor and aroma of the product. Strain selection is one of the key steps. Utilizing scientific breeding technology, the relationship between strains can be managed, the composition of the alcoholic beverage microbial community can be improved, and the quality and flavor of the alcoholic beverage products can be increased. Currently, research on the microbial diversity of alcohol beverages has received extensive attention. However, the selection technology for dominant bacteria in alcohol beverages has not yet been systematically summarized. To breed better-quality alcohol beverage strains and improve the quality and characteristics of wine, this paper introduces the microbial diversity characteristics of the world’s three major brewing alcohols: beer, wine, and yellow wine, as well as the breeding technologies of related strains. The application of culture selection technology in the study of microbial diversity of brewed wine was reviewed and analyzed. The strain selection technology and alcohol beverage process should be combined to explore the potential application of a diverse array of alcohol beverage strains, thereby boosting the quality and flavor of the alcohol beverage and driving the sustainable development of the alcoholic beverage industry. Full article
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26 pages, 2166 KiB  
Article
Modeling the Critical Factors Affecting the Success of Online Architectural Education to Enhance Educational Sustainability
by Yusuf Berkay Metinal and Gulden Gumusburun Ayalp
Sustainability 2024, 16(9), 3803; https://doi.org/10.3390/su16093803 (registering DOI) - 01 May 2024
Abstract
Due to their unique requirements, the COVID-19 pandemic precipitated an urgent shift toward online education, profoundly impacting disciplines such as architectural education (AE). While online education has demonstrated efficacy in theoretical domains, practical disciplines like AE face significant challenges, particularly in design studios [...] Read more.
Due to their unique requirements, the COVID-19 pandemic precipitated an urgent shift toward online education, profoundly impacting disciplines such as architectural education (AE). While online education has demonstrated efficacy in theoretical domains, practical disciplines like AE face significant challenges, particularly in design studios (DS). This study aims to identify the critical factors affecting the success of online architectural education for sustaining educational quality amid crises. A comprehensive systematic literature review was undertaken, followed by the development of a questionnaire encompassing 53 challenges pertinent to online architectural education (OAE). The questionnaire was administered to architecture students who had experienced OAE, resulting in 232 fully completed responses. Twenty-four critical challenges (CCs) were identified through normalized mean value analysis. Exploratory factor analysis revealed three pivotal factors, subsequently validated by confirmatory factor analysis. A structural equation model (SEM) was constructed to elucidate the magnitude of impact exerted by these critical factors on the success of OAE. Critical challenge factors encompassed obstacles to (1) interactive, communicative, and collaborative social learning, (2) inexperience and technical constraints, and (3) enhanced accessibility, and self-sufficiency. These findings represent a first and novel contribution to this domain, distinct from previous research endeavors, by delineating the primary factors critical to the success of OAE. Full article
(This article belongs to the Section Sustainable Education and Approaches)
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13 pages, 2219 KiB  
Article
Antiparasitic Activity of Enterocin M and Durancin-like from Beneficial Enterococci in Mice Experimentally Infected with Trichinella spiralis
by Miroslava Petrová, Zuzana Hurníková, Andrea Lauková and Emília Dvorožňáková
Microorganisms 2024, 12(5), 923; https://doi.org/10.3390/microorganisms12050923 (registering DOI) - 01 May 2024
Abstract
Beneficial/probiotic strains protect the host from pathogens by competitive displacement and production of antibacterial substances, i.e., bacteriocins. The antiparasitic potential of bacteriocins/enterocins and their producing strains in experimental murine trichinellosis were tested as a new therapeutic strategy. Enterocin M and Durancin-like and their [...] Read more.
Beneficial/probiotic strains protect the host from pathogens by competitive displacement and production of antibacterial substances, i.e., bacteriocins. The antiparasitic potential of bacteriocins/enterocins and their producing strains in experimental murine trichinellosis were tested as a new therapeutic strategy. Enterocin M and Durancin-like and their producers Enterococcus faecium CCM8558 and Enterococcus durans ED26E/7 were administered daily to mice that were challenged with Trichinella spiralis. Our study confirmed the antiparasitic effect of enterocins/enterococci, which reduced the number of adults in the intestine (Enterocin M—43.8%, E. faecium CCM8558—54.5%, Durancin-like—16.4%, E. durans ED26E/7—35.7%), suppressed the Trichinella reproductive capacity ex vivo (Enterocin M—61%, E. faecium CCM8558—74%, Durancin-like—38%, E. durans ED26E/7—66%), and reduced the number of muscle larvae (Enterocin M—39.6%, E. faecium CCM8558—55.7%, Durancin-like—15%, E. durans ED26E/7—36.3%). The direct effect of enterocins on Trichinella fecundity was documented by an in vitro test in which Durancin-like showed a comparable reducing effect to Enterocin M (40–60%) in contrast to the ex vivo test. The reducing activity of T.spiralis infection induced by Enterocin M was comparable to its strain E. faecium CCM8558; Durancin-like showed lower antiparasitic activity than its producer E. durans ED26E/7. Full article
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15 pages, 1033 KiB  
Article
Training of a Neural Network System in the Task of Detecting Blue Stains in a Sawmill Wood Inspection System
by Piotr Wolszczak, Grzegorz Kotnarowski, Arkadiusz Małek and Grzegorz Litak
Appl. Sci. 2024, 14(9), 3885; https://doi.org/10.3390/app14093885 (registering DOI) - 01 May 2024
Abstract
This article presents the operation of an automatic pine sawn timber inspection system, which was developed at the Woodinspector company and is offered commercially. The vision inspection system is used to detect various wood defects, including knots, blue stain, and mechanical damage caused [...] Read more.
This article presents the operation of an automatic pine sawn timber inspection system, which was developed at the Woodinspector company and is offered commercially. The vision inspection system is used to detect various wood defects, including knots, blue stain, and mechanical damage caused by worms. A blue stain is a defect that is difficult to detect based on the color of the wood, because it can be easily confused with wood defects or dirt that do not impair its strength properties. In particular, the issues of detecting blue stain in wood, the use of artificial neural networks, and improving the operation of the system in production conditions are discussed in this article. While training the network, 400 boards, 4 m long, and their cross-sections of 100 × 25 [mm] were used and photographed using special scanners with laser illuminators from four sides. The test stages were carried out during an 8-hour workday at a sawmill (8224 m of material was scanned) on material with an average of 10% blue stain (every 10th board has more than 30% of its length stained blue). The final learning error was assessed based on defective boards detected by humans after the automatic selection stage. The system error for 5387 boards, 550 m long, which had blue staining that was not detected by the scanner (clean) was 0.4% (25 pieces from 5387), and 0.1 % in the case of 3412 boards, 610 mm long, on which there were no blue stains, but were wrongly classified (blue stain). For 6491 finger-joint boards (180–400 mm), 48 pieces were classified as class 1 (clean), but had a blue stain (48/6491 = 0.7%), and 28 pieces did not have a blue stain, but were classified as class 2 (28/3561 = 0.7%). Full article
(This article belongs to the Special Issue Applications of Vision Measurement System on Product Quality Control)
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20 pages, 10078 KiB  
Article
Effect of Morphology Modification of BiFeO3 on Photocatalytic Efficacy of P-g-C3N4/BiFeO3 Composites
by Abubakar Usman Katsina, Diana-Luciana Cursaru, Dănuţa Matei and Sonia Mihai
Int. J. Mol. Sci. 2024, 25(9), 4948; https://doi.org/10.3390/ijms25094948 (registering DOI) - 01 May 2024
Abstract
This current study assessed the impacts of morphology adjustment of perovskite BiFeO3 (BFO) on the construction and photocatalytic activity of P-infused g-C3N4/U-BiFeO3 (U-BFO/PCN) heterostructured composite photocatalysts. Favorable formation of U-BFO/PCN composites was attained via urea-aided morphology-controlled hydrothermal [...] Read more.
This current study assessed the impacts of morphology adjustment of perovskite BiFeO3 (BFO) on the construction and photocatalytic activity of P-infused g-C3N4/U-BiFeO3 (U-BFO/PCN) heterostructured composite photocatalysts. Favorable formation of U-BFO/PCN composites was attained via urea-aided morphology-controlled hydrothermal synthesis of BFO followed by solvosonication-mediated fusion with already synthesized P-g-C3N4 to form U-BFO/PCN composites. The prepared bare and composite photocatalysts’ morphological, textural, structural, optical, and photocatalytic performance were meticulously examined through various analytical characterization techniques and photodegradation of aqueous rhodamine B (RhB). Ellipsoids and flakes morphological structures were obtained for U-BFO and BFO, and their effects on the successful fabrication of the heterojunctions were also established. The U-BFO/PCN composite exhibits 99.2% efficiency within 20 min of visible-light irradiation, surpassing BFO/PCN (88.5%), PCN (66.8%), and U-BFO (26.1%). The pseudo-first-order kinetics of U-BFO/PCN composites is 2.41 × 10−1 min−1, equivalent to 2.2 times, 57 times, and 4.3 times of BFO/PCN (1.08 × 10−1 min−1), U-BFO, (4.20 × 10−3 min−1), and PCN, (5.60 × 10−2 min−1), respectively. The recyclability test demonstrates an outstanding photostability for U-BFO/PCN after four cyclic runs. This improved photocatalytic activity exhibited by the composites can be attributed to enhanced visible-light utilization and additional accessible active sites due to surface and electronic band modification of CN via P-doping and effective charge separation achieved via successful composites formation. Full article
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18 pages, 2542 KiB  
Article
Cold Atmospheric Pressure Plasma-Activated Medium Modulates Cellular Functions of Human Mesenchymal Stem/Stromal Cells In Vitro
by Olga Hahn, Tawakalitu Okikiola Waheed, Kaarthik Sridharan, Thomas Huemerlehner, Susanne Staehlke, Mario Thürling, Lars Boeckmann, Mareike Meister, Kai Masur and Kirsten Peters
Int. J. Mol. Sci. 2024, 25(9), 4944; https://doi.org/10.3390/ijms25094944 (registering DOI) - 01 May 2024
Abstract
Cold atmospheric pressure plasma (CAP) offers a variety of therapeutic possibilities and induces the formation of reactive chemical species associated with oxidative stress. Mesenchymal stem/stromal cells (MSCs) play a central role in tissue regeneration, partly because of their antioxidant properties and ability to [...] Read more.
Cold atmospheric pressure plasma (CAP) offers a variety of therapeutic possibilities and induces the formation of reactive chemical species associated with oxidative stress. Mesenchymal stem/stromal cells (MSCs) play a central role in tissue regeneration, partly because of their antioxidant properties and ability to migrate into regenerating areas. During the therapeutic application, MSCs are directly exposed to the reactive species of CAP. Therefore, the investigation of CAP-induced effects on MSCs is essential. In this study, we quantified the amount of ROS due to the CAP activation of the culture medium. In addition, cell number, metabolic activity, stress signals, and migration were analyzed after the treatment of MSCs with a CAP-activated medium. CAP-activated media induced a significant increase in ROS but did not cause cytotoxic effects on MSCs when the treatment was singular and short-term (one day). This single treatment led to increased cell migration, an essential process in wound healing. In parallel, there was an increase in various cell stress proteins, indicating an adaptation to oxidative stress. Repeated treatments with the CAP-activated medium impaired the viability of the MSCs. The results shown here provide information on the influence of treatment frequency and intensity, which could be necessary for the therapeutic application of CAP. Full article
(This article belongs to the Special Issue Plasma Bioscience and Medicine Molecular Research 2.0)
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14 pages, 7720 KiB  
Article
Non-Contact Wind Turbine Blade Crack Detection Using Laser Doppler Vibrometers
by Ali Zabihi, Farhood Aghdasi, Chadi Ellouzi, Nand Kishore Singh, Ratneshwar Jha and Chen Shen
Energies 2024, 17(9), 2165; https://doi.org/10.3390/en17092165 (registering DOI) - 01 May 2024
Abstract
In response to the growing global demand for both energy and a clean environment, there has been an unprecedented rise in the utilization of renewable energy. Wind energy plays a crucial role in striving for carbon neutrality due to its eco-friendly characteristics. Despite [...] Read more.
In response to the growing global demand for both energy and a clean environment, there has been an unprecedented rise in the utilization of renewable energy. Wind energy plays a crucial role in striving for carbon neutrality due to its eco-friendly characteristics. Despite its significance, wind energy infrastructure is susceptible to damage from various factors including wind or sea waves, rapidly changing environmental conditions, delamination, crack formation, and structural deterioration over time. This research focuses on investigating non-destructive testing (NDT) of wind turbine blades (WTBs) using approaches based on the vibration of the structures. To this end, WTBs are first made from glass fiber-reinforcement polymer (GFRP) using composite molding techniques, and then a short pulse is generated in the structure by a piezoelectric actuator made from lead zirconate titanate (PZT-5H) to generate guided waves. A numerical approach is presented based on solving the elastic time-harmonic wave equations, and a laser Doppler vibrometer (LDV) is utilized to collect the vibrational data in a remote manner, thereby facilitating the crack detection of WTBs. Subsequently, the wave propagation characteristics of intact and damaged structures are analyzed using the Hilbert–Huang transformation (HHT) and fast Fourier transformation (FFT). The results reveal noteworthy distinctions in damaged structures, where the frequency domain exhibits additional components beyond those identified by FFT, and the time domain displays irregularities in proximity to the crack region, as detected by HHT. The results suggest a feasible approach to detecting potential cracks of WTBs in a non-contact and reliable way. Full article
(This article belongs to the Special Issue Latest Developments in Offshore Wind Technologies)
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12 pages, 1233 KiB  
Article
Functional and Combined Training Promote Body Recomposition and Lower Limb Strength in Postmenopausal Women: A Randomized Clinical Trial and a Time Course Analysis
by Marcos Raphael Pereira-Monteiro, José Carlos Aragão-Santos, Alan Bruno Silva Vasconcelos, Antônio Gomes de Resende-Neto, André Filipe Santos de Almeida, Luis Alberto Gobbo, Francisco Hermosilla-Perona, Juan Ramón Heredia-Elvar, Fabricio Boscolo Del Vecchio, Felipe J. Aidar and Marzo Edir Da Silva-Grigoletto
Healthcare 2024, 12(9), 932; https://doi.org/10.3390/healthcare12090932 (registering DOI) - 01 May 2024
Abstract
Encouraging healthy aging in postmenopausal women involves advocating for lifestyle modifications, including regular physical exercise like combined training (CT) and functional training (FT). Regarding this population, age-related alterations in body composition, such as decreased muscle mass and heightened adipose tissue, impact health. The [...] Read more.
Encouraging healthy aging in postmenopausal women involves advocating for lifestyle modifications, including regular physical exercise like combined training (CT) and functional training (FT). Regarding this population, age-related alterations in body composition, such as decreased muscle mass and heightened adipose tissue, impact health. The aim of this study was to analyze the effects of FT and CT on body recomposition in postmenopausal women. About the methods, we randomly allocated 96 post-menopausal women to the FT, CT, or control group (CG). We measured body composition by bioimpedance and lower limb muscle strength by sit-to-stand test in five repetitions, respectively. The training protocol lasted 16 weeks, and we measured body composition and lower limb muscle strength every 4 weeks, totaling five assessments. Regarding results, we notice that both training groups increased lean mass from the 8th week of training. In addition, a reduction was observed in total fat percentage and an increase in appendicular lean mass from the 12th week of intervention. No differences were found for body mass. Furthermore, only the experimental groups increase muscle strength, starting from the 4th week of training. The conclusion was that FT and CT promote similar adaptations in body recomposition without affecting body mass in postmenopausal women. Full article
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15 pages, 2032 KiB  
Article
UVC Stokes and Anti-Stokes Emission of Ca9Y(PO4)7 Polycrystals Doped with Pr3+ Ions
by Karol Lemański, Olha Bezkrovna, Nadiia Rebrova, Radosław Lisiecki, Patrycja Zdeb and Przemysław Jacek Dereń
Molecules 2024, 29(9), 2084; https://doi.org/10.3390/molecules29092084 (registering DOI) - 01 May 2024
Abstract
The recent COVID-19 pandemic has made everyone aware of the threat of viruses and the growing number of antibiotic-resistant bacteria. It has become necessary to find new methods to combat these hazards. One tool that could be used is UVC radiation, i.e., 100–280 [...] Read more.
The recent COVID-19 pandemic has made everyone aware of the threat of viruses and the growing number of antibiotic-resistant bacteria. It has become necessary to find new methods to combat these hazards. One tool that could be used is UVC radiation, i.e., 100–280 nm. Currently, the available sources of this light are mercury vapor lamps. However, the modern world requires more compact, mercury-free, and less energy-consuming light sources. This work presents the results of our research on a new material in which efficient UVC radiation was obtained. Here, we present the results of research on Ca9Y(PO4)7 polycrystals doped with Pr3+ ions prepared using the solid-state method. The absorption, excitation, emission, and emission decay profiles of praseodymium(III) ions were measured and analyzed. The upconversion emission in the UVC region excited by blue light was observed. Parameters such as energy bandgap, refractive index, and thermal stability of luminescence were determined. The studied phosphate-based phosphor possesses promising characteristics that show its potential in luminescent applications in future use in medicine or for surface disinfection. Full article
(This article belongs to the Section Physical Chemistry)
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17 pages, 6760 KiB  
Article
Abundance and Seasonal Migration Patterns of Green Lacewings (Neuroptera: Chrysopidae) across the Bohai Strait in Eastern Asia
by Xingya Wang, Haotian Ma, Yuechao Zhao, Ying Gao and Kongming Wu
Insects 2024, 15(5), 321; https://doi.org/10.3390/insects15050321 (registering DOI) - 01 May 2024
Abstract
Many insects, including green lacewings, migrate seasonally to exploit suitable breeding and winter habitats. Green lacewings are important natural enemies of insect pests worldwide. Here, four dominant green lacewing species, Chrysoperla nipponensis (Okamoto), Chrysopa pallens (Rambur), Chrysoperla furcifera (Okamoto), and Chrysopa formosa Brauer [...] Read more.
Many insects, including green lacewings, migrate seasonally to exploit suitable breeding and winter habitats. Green lacewings are important natural enemies of insect pests worldwide. Here, four dominant green lacewing species, Chrysoperla nipponensis (Okamoto), Chrysopa pallens (Rambur), Chrysoperla furcifera (Okamoto), and Chrysopa formosa Brauer, were investigated for their ability to migrate between northern and northeastern China across the Bohai Strait from late May to late October each year. Furthermore, there were significant interannual and seasonal differences in the number of migratory green lacewings collected. The number of green lacewings in spring was significantly lower than that in summer and autumn, and the highest average number of green lacewings occurred in June. In addition, there were differences in the sex ratio of migrating green lacewings between months, with a greater proportion of females than males. Finally, the seasonal migration trajectories simulated by the HYSPLIT model revealed that the green lacewings captured on Beihuang Island primarily originated from Shandong Province. Accordingly, these findings contribute to our understanding of green lacewing migration in eastern Asia and aid its incorporation within integrated pest management (IPM) packages for several crop pests. Furthermore, long-term tracking of migrant insect populations can reveal ecosystem services and trophic dynamic processes at the macroscale. Full article
(This article belongs to the Section Insect Ecology, Diversity and Conservation)
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7 pages, 1002 KiB  
Brief Report
Ethnicity-Based Variations in Focal Adhesion Kinase Signaling in Glioblastoma Gene Expression: A Study of the Puerto Rican Hispanic Population
by Tyrel Porter, Miguel Mayol del Valle and Lilia Kucheryavykh
Int. J. Mol. Sci. 2024, 25(9), 4947; https://doi.org/10.3390/ijms25094947 (registering DOI) - 01 May 2024
Abstract
Glioblastoma (GBM), an aggressive form of brain cancer, has a higher incidence in non-Hispanics when compared to the US Hispanic population. Using data from RT-PCR analysis of 21 GBM tissue from Hispanic patients in Puerto Rico, we identified significant correlations in the gene [...] Read more.
Glioblastoma (GBM), an aggressive form of brain cancer, has a higher incidence in non-Hispanics when compared to the US Hispanic population. Using data from RT-PCR analysis of 21 GBM tissue from Hispanic patients in Puerto Rico, we identified significant correlations in the gene expression of focal adhesion kinase and proline-rich tyrosine kinase (PTK2 and PTK2B) with NGFR (nerve growth factor receptor), PDGFRB (platelet-derived growth factor receptor B), EGFR (epithelial growth factor receptor), and CXCR1 (C-X-C motif chemokine receptor 1). This study further explores these correlations found in gene expression while accounting for sex and ethnicity. Statistically significant (p < 0.05) correlations with an r value > ±0.7 were subsequently contrasted with mRNA expression data acquired from cBioPortal for 323 GBM specimens. Significant correlations in Puerto Rican male patients were found between PTK2 and PTK2B, NGFR, PDGFRB, EGFR, and CXCR1, which did not arise in non-Hispanic male patient data. The data for Puerto Rican female patients showed correlations in PTK2 with PTK2B, NGFR, PDGFRB, and EGFR, all of which did not appear in the data for non-Hispanic female patients. The data acquired from cBioPortal for non-Puerto Rican Hispanic patients supported the correlations found in the Puerto Rican population for both sexes. Our findings reveal distinct correlations in gene expression patterns, particularly involving PTK2, PTK2B, NGFR, PDGFRB, and EGFR among Puerto Rican Hispanic patients when compared to non-Hispanic counterparts. Full article
(This article belongs to the Special Issue Novel Therapeutic Targets in Cancers 3.0)
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17 pages, 6075 KiB  
Article
Study on the Damage Mechanism of Coal under Hydraulic Load
by Hongyan Li, Yaolong Li, Weihua Wang, Yang Li, Zhongxue Sun, Shi He and Yongpeng Fan
Processes 2024, 12(5), 925; https://doi.org/10.3390/pr12050925 (registering DOI) - 01 May 2024
Abstract
Hydraulic fracturing is extensively utilized for the prevention and control of gas outbursts and rockbursts in the deep sections of coal mines. The determination of fracturing construction parameters based on the coal seam conditions and stress environments merits further investigation. This paper constructs [...] Read more.
Hydraulic fracturing is extensively utilized for the prevention and control of gas outbursts and rockbursts in the deep sections of coal mines. The determination of fracturing construction parameters based on the coal seam conditions and stress environments merits further investigation. This paper constructs a damage analysis model for coal under hydraulic loads, factoring in the influence of the intermediate principal stress, grounded in the unified strength theory analysis approach. It deduces the theoretical analytical equation for the damage distribution of a coal medium subjected to small-flow-rate hydraulic fracturing in underground coal mines. Laboratory experiments yielded the mechanical parameters of coal in the study area and facilitated the fitting of the intermediate principal stress coefficient. Leveraging these datasets, the study probes into the interaction between hydraulic loads and damage radius under assorted influence ranges, porosity, far-field crustal stresses, and brittle damage coefficients. The findings underscore that hydraulic load escalates exponentially with the damage radius. Within the variable range of geological conditions in the test area, the effects of varying influence range, porosity level, far-field stress, and brittle damage coefficient on the outcomes intensify one by one; a larger hydraulic load diminishes the impact of far-field stress variations on the damage radius, inversely to the influence range, porosity, and brittle damage. The damage radius derived through the gas pressure reduction method in field applications corroborates the theoretical calculations, affirming the precision of the theoretical model. These findings render pivotal guidance for the design and efficacy assessment of small-scale hydraulic fracturing in underground coal mines. Full article
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11 pages, 15756 KiB  
Article
Advanced Integration of Microwave Kiln Technology in Enhancing the Lost-Wax Glass Casting Process: A Study on Methodological Innovations and Practical Implications
by Shu-Chen Cheng, Ming-Shan Kao and Jiunn-Jer Hwang
J. Compos. Sci. 2024, 8(5), 168; https://doi.org/10.3390/jcs8050168 (registering DOI) - 01 May 2024
Abstract
Lost-wax glass casting, an esteemed yet technically demanding art form, traditionally relies on specialized, costly kiln equipment, presenting significant barriers to artists regarding equipment affordability, energy efficiency, and the technical mastery required for temperature control. Therefore, this study introduces an innovative approach by [...] Read more.
Lost-wax glass casting, an esteemed yet technically demanding art form, traditionally relies on specialized, costly kiln equipment, presenting significant barriers to artists regarding equipment affordability, energy efficiency, and the technical mastery required for temperature control. Therefore, this study introduces an innovative approach by integrating a microwave kiln with standard household microwave ovens, thus facilitating the lost-wax glass casting process. This methodological adaptation allows artists to employ readily available home appliances for glass creation, significantly reducing the process’s cost and complexity. Our experimental investigations reveal that, by using a 500W household microwave oven for heating, the silicon carbide (SiC) in microwave kilns can efficiently absorb microwave energy, allowing the kilns to reach temperatures exceeding 700 °C, a critical threshold for casting glass softening. We further demonstrate that by adjusting the number of heating cycles, producing high-quality, three-dimensional(3D) glass artworks is feasible, even for large-scale projects. In addition, the microwave kiln can be used as an effective cooling tool to uniformly cool the formed casting glass. This study presents a possible alternative to conventional kiln technology and marks a paradigm shift in glassmaking, offering a more accessible and sustainable avenue for artists and practitioners. Full article
(This article belongs to the Special Issue Functional Composites: Fabrication and Application)
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11 pages, 5565 KiB  
Article
Green Strong Cornstalk Rind-Based Cellulose-PVA Aerogel for Oil Adsorption and Thermal Insulation
by Xiaoyang Yi, Zhongxu Zhang, Junfeng Niu, Hongyan Wang, Tiankun Li, Junjie Gong and Rongbo Zheng
Polymers 2024, 16(9), 1260; https://doi.org/10.3390/polym16091260 (registering DOI) - 01 May 2024
Abstract
Cellulose-based aerogel has attracted considerable attention for its excellent adsorption capacity, biodegradability, and renewability. However, it is considered eco-unfriendly due to defibrillation of agriculture waste and requires harmful/expensive chemical agents. In this study, cornstalk rind-based aerogel was obtained via the following steps: green [...] Read more.
Cellulose-based aerogel has attracted considerable attention for its excellent adsorption capacity, biodegradability, and renewability. However, it is considered eco-unfriendly due to defibrillation of agriculture waste and requires harmful/expensive chemical agents. In this study, cornstalk rind-based aerogel was obtained via the following steps: green H2O2/HAc delignification of cornstalk rind to obtain cellulose fibers, binding with carboxymethyl cellulose (CMC)/polyvinyl alcohol (PVA) and freeze-drying treatment, and hydrophobic modification with stearic acid. The obtained aerogel showed high compressive strength (200 KPa), which is apparently higher (about 32 kPa) than NaClO-delignified cornstalk-based cellulose/PVA aerogel. Characterization of the obtained aerogel through SEM, water contact angle, etc., showed high porosity (95%), low density (0.0198 g/cm−3), and hydrophobicity (water contact angle, 159°), resulting in excellent n-hexane adsorption capacity (35 g/g), higher (about 29.5 g/g) than NaClO-delignified cornstalk-based cellulose/PVA aerogel. The adsorbed oil was recovered by the extrusion method, and the aerogel showed excellent recyclability in oil adsorption. Full article
(This article belongs to the Special Issue Advances in Cellulose-Based Polymers and Composites, 2nd Edition)
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20 pages, 7581 KiB  
Article
GIS-Based Regional Seismic Risk Assessment for Dubai, UAE, Using NHERI SimCenter R2D Application
by Ahmed Mansour Maky, Mohammad AlHamaydeh and Mona Saleh
Buildings 2024, 14(5), 1277; https://doi.org/10.3390/buildings14051277 (registering DOI) - 01 May 2024
Abstract
Over the last two decades, the UAE’s construction sector has grown significantly with the development of tall buildings, but the region faces seismic risks. Similar concerns in China led to earthquake simulation research on a city scale. The objectives include developing programming for [...] Read more.
Over the last two decades, the UAE’s construction sector has grown significantly with the development of tall buildings, but the region faces seismic risks. Similar concerns in China led to earthquake simulation research on a city scale. The objectives include developing programming for parallel computing and creating simplified models for estimating losses. The challenges include computational complexity and uncertainties in various modules. In 1995, the structural engineering community adopted performance-based engineering principles, shifting to a probabilistic design process. The Computational Modeling and Simulation Center (SimCenter) implemented this into a generic software platform, with the 2010 release of Regional Resilience Determination (R2D) automating the methodology. A research plan aims to advance realistic seismic simulation in the UAE, integrating studies and custom developments. The goal is to create an end-to-end seismic risk assessment framework aligned with digital trends, such as BIM and GIS. The investigation focuses on a virtual dataset for tall buildings, considering variations in location, material properties, height, and seismic activity. For the studied archetypes, the average expected losses include a 3.6% collapse probability, a 14% repair cost, 22 days repair time per asset, and almost 1.5% total population injuries, ranging from 1% for the lowest severity to 0.15% for the highest. Full article
(This article belongs to the Special Issue Maintenance, Repair and Rehabilitation of Building Structures)
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