With growing mental health concerns among college students, they need to effectively develop skills to alleviate stress amidst the demands of university life. Teaching mindfulness skills to engineering students early in their programs, such as during introductory courses, may provide students with the tools they need to effectively cope with academic stressors, support well-being, and mitigate mental health concerns. This study aimed to understand the variation in experiences of engineering students who participated in weekly mindfulness meditation during a first-year cornerstone engineering course. This study used a thematic analysis approach to analyze students’ in-class, weekly reflections from eight meditation exercises across two course sections. The frequency of codes and themes were then analyzed across meditation types to identify trends in student experiences. Our results show that the most common student experience from engaging in mindfulness meditation was feeling less stressed, calmer, and more relaxed. Other positive experiences include feeling more energized and focused. Some students, however, did report some negative experiences, such as distress and tiredness. The Dynamic Breathing exercise, in particular, showed higher rates of negative experiences than other meditation types. The results also demonstrate that different types of meditations produce different student experiences. Meditation exercises with open monitoring components showed higher rates of insight/awareness and difficulty focusing attention than focused attention meditations. These findings indicate that utilizing weekly mindfulness exercises in introductory engineering courses can benefit students’ overall mental health and well-being when adequately implemented. Full article

For either healthy or diseased organisms, lipids are key components for cellular membranes; they play important roles in numerous cellular processes including cell growth, proliferation, differentiation, energy storage and signaling. Exercise and disease development are examples of cellular environment alterations which produce changes in these networks. There are indications that alterations in lipid metabolism contribute to the development and progression of a variety of cancers. Measuring such alterations and understanding the pathways involved is critical to fully understand cellular metabolism. The demands for this information have led to the emergence of lipidomics, which enables the large-scale study of lipids using mass spectrometry (MS) techniques. Mass spectrometry has been widely used in lipidomics and allows us to analyze detailed lipid profiles of cancers. In this article, we discuss emerging strategies for lipidomics by mass spectrometry; targeted, as opposed to global, lipid analysis provides an exciting new alternative method. Additionally, we provide an introduction to lipidomics, lipid categories and their major biological functions, along with lipidomics studies by mass spectrometry in cancer samples. Further, we summarize the importance of lipid metabolism in oncology and tumor microenvironment, some of the challenges for lipodomics, and the potential for targeted approaches for screening pharmaceutical candidates to improve the therapeutic efficacy of treatment in cancer patients. Full article

Analysis of the scented components of the art installation House of Hope by Montien Boonma, including eight bags of unlabeled or poorly labeled powder and five strands of aromatic beads, was completed to facilitate its display at the Museum of Modern Art (MoMA). Though an olfactory experience is central to the piece, limited information was available concerning the origin of the object’s scent. Identification of the aromas from the powders and beads, some of which were nearly 30 years old, was accomplished through visual assessment, attenuated total reflectance–Fourier-transform infrared spectroscopy (ATR-FTIR), and static headspace solid-phase microextraction gas chromatography–mass spectrometry (HS-SPME-GCMS) and confirmed using controls. Challenges included spices that had lost some of their potency or become cross-contaminated. The contents of five of the eight bags of powder were successfully identified as black pepper (two bags), clove, turmeric, and white sandalwood (Santalum album). All beads contained nutmeg, peppermint, ginger, and turmeric, while licorice root, thyme, cardamom, and clove were noted in some. The beads were bound using pine honey, a unique type of honey produced by bees that feed on aphid excretions. Identifying the scented components informs current and future installations so that the artist’s original intent is more closely approximated. Full article

To construct a diverse anticipatory practice for the future of science parks, this work gives a systematic understanding of the effect of the regional background on the benefit of science parks, and of the synergy of the elements of the innovation system, which contains a space dimension and regional differences, and represents the unique characteristics of the regional environment at various geographic scales. This work examines the function and effect of different geographic scales on the conditions required for the evolution of science parks based on regional innovation systems. The research analyzes the implications of the development of science parks through different spatial scales from the perspective of the regional innovation system. The function of innovation in the Hsinchu and Southern Taiwan Science Parks is examined by comparing the two parks, confirming the effect of different regional backgrounds on the benefit of the science parks. Full article

Extended back electromotive force (EEMF)-based position sensorless field-oriented control (FOC) is widely utilized for ultra-high-speed surface-mounted permanent magnet synchronous motors (UHS-SPMSMs) driven fuel cell air compressors in medium-high speed applications. Unfortunately, the estimated position is imprecise due to too small EEMF under low speed operation. Hence, current-to-frequency (I-f) control is more suitable for startup. Conventional I-f methods rarely achieve the tradeoff between startup acceleration and load capacity, and the transition to sensorless FOC is mostly realized in the constant-speed stage, which is unacceptable for UHS-SPMSM considering the critical requirement of startup time. In this article, a new closed-loop I-f control approach is proposed to achieve fast and efficient startup. The frequency of reference current vector is corrected automatically based on the active power and the real-time motor torque, which contributes to damping effect for startup reliability. Moreover, an amplitude compensator of reference current vector is designed based on the reactive power, ensuring the maximum torque per ampere operation and higher efficiency. Furthermore, the speed PI controller is enhanced by variable bandwidth design for smoother sensorless transition. These theoretical advantages are validated through experiments with a 550 V, 35 kW UHS-SPMSM. The experimental results demonstrated the enhanced startup performance compared with conventional I-f control. Full article

This scoping review synthesizes the evidence from eleven key studies to assess the impact of European Structural and Investment Funds (ESIFs) on regional development across the European Union (EU), focusing on fund efficiency, regional disparities and convergence, governance quality, economic freedom, and fund management. A systematic search was conducted across multiple databases to identify the relevant literature published up to 2023. Eleven studies were selected based on the date published and their focus on ESIFs’ role in regional development, employing a range of methodological approaches including Data Envelopment Analysis (DEA), spatial econometrics, and multivariate analyses. The thematic analysis identified four main categories: Methodological Approaches in Evaluating Fund Efficiency, Regional Disparities and Convergence, The Interconnection between Governance Quality, Economic Freedom, and the Efficiency of Structural Fund Management, and The Absorption Capacity and Fund Management. The review highlights the importance of sophisticated analytical tools in evaluating fund efficiency, with DEA and spatial econometrics providing critical insights into fund management efficiency. Studies underscored the nuanced efficacy of ESIFs in reducing regional disparities, albeit pointing to the need for more targeted fund allocation. Governance quality and economic freedom emerged as pivotal factors enhancing fund management efficiency, suggesting the potential of governance reforms in optimizing ESIF allocation and utilization. Challenges related to fund absorption and management were illuminated, advocating for enhanced institutional management capabilities and the development of innovative performance indicators. The findings of this scoping review contribute to a deeper understanding of the complexities surrounding ESIFs’ impact on regional development within the EU. They underscore the critical importance of governance quality, economic freedom, methodological rigor, and strategic fund allocation in enhancing the effectiveness of ESIFs. The review calls for tailored policy interventions and the integration of national and European funding strategies to maximize the impact of these programs on regional development and SME support. Future research should continue to refine these methodological approaches and explore the causal effects of funding, to enhance our understanding of ESIFs’ efficiency in promoting regional development and convergence within the European Union. Full article

Urea stands as a ubiquitous environmental contaminant. However, not only does urea oxidation reaction technology facilitate energy conversion, but it also significantly contributes to treating wastewater rich in urea. Furthermore, urea electrolysis has a significantly lower theoretical potential (0.37 V) compared to water electrolysis (1.23 V). As an electrochemical reaction, the catalytic efficacy of urea oxidation is largely contingent upon the catalyst employed. Among the plethora of urea oxidation electrocatalysts, nickel-based compounds emerge as the preeminent transition metal due to their cost-effectiveness and heightened activity in urea oxidation. Ni(OH)₂ is endowed with manifold advantages, including structural versatility, facile synthesis, and stability in alkaline environments. This review delineates the recent advancements in Ni(OH)₂ catalysts for electrocatalytic urea oxidation reaction, encapsulating pivotal research findings in morphology, dopant incorporation, defect engineering, and heterogeneous architectures. Additionally, we have proposed personal insights into the challenges encountered in the research on nickel hydroxide for urea oxidation, aiming to promote efficient urea conversion and facilitate its practical applications. Full article

Fixed appliance (FA) therapy predisposes patients to white spot lesions (WSLs). The F-ACP complex (amorphous calcium phosphate nanoparticles enriched with carbonate and fluorine and coated with citrate) has been effective for in vitro enamel remineralization. The aim of this study was to evaluate the efficacy of the F-ACP complex in remineralizing WSLs after FA therapy. One hundred and six adolescents (aged 12–20 years) were randomized into study and control groups after FA therapy. Patients in the study group were advised to use dental mousse containing F-ACP applied within Essix retainers for six months. The presence of WSLs was recorded at baseline (T0), 3 months (T1), and 6 months (T2) according to the International Caries Detection and Assessment System (ICDAS). Visual Plaque Index (VPI) and Gingival Bleeding Index (GBI) were recorded. Among 106 study participants, 91 (52 and 39 in study and control groups, respectively) completed the study. The results showed that the ICDAS score was significantly lower (p < 0.001) in the study group than in the control group between T0 and T2. The application of mousse containing the F-ACP complex inside Essix retainers for six months is effective in remineralizing white spot lesions in patients after FA therapy without side effects. Full article

Water pollution has become a major environmental menace due to municipal and industrial effluents discharged into water bodies. Several processes have been devised for the treatment and disposal of wastewater and sludge. Yet, most of the conventional technologies do not meet the requirements of sustainability as they impose a higher load on the environment in terms of resource depletion and toxic waste generation. Recently, sustainable innovative technologies, like hydrodynamic cavitation (HC), have emerged as energy-efficient methods, which can enhance the conventional wastewater treatment processes. HC is a very effective technique for the intensification of processes, like aeration, activated sludge treatment, and anaerobic digestion processes in conventional wastewater treatment plants, particularly for the enhanced degradation of persistent pollutants. On the other hand, advanced oxidation is a proven enhancement method for wastewater treatment. This review provides a comprehensive overview of recently published literature on the application of HC for the treatment of persistent organic pollutants. The potential synergistic impact of HC coupled with advanced oxidation and alternative pre-treatment methods was also reviewed in this study. Moreover, an overview of the present state of model-based research work for HC reactors and a feasibility analysis of various advanced oxidation process is also covered. Options for the pilot-to-large scale implementation of HC and advanced oxidation technologies to ensure the better sustainability of wastewater treatment plants are recommended. Full article

Gaussian filtering, being a convolution with a Gaussian kernel, is a widespread technique in image analysis and computer vision applications. It is the traditional approach for noise reduction. In some cases, performing the exact convolution can be computationally expensive and time-consuming. To address this problem, approximations of the convolution are often used to achieve a balance between accuracy and computational efficiency, such as with running sums, Bell blur, Deriche approximation, etc. At the same time, modern computing devices support data parallelism (vectorization) via Single Instruction Multiple Data (SIMD) and can process integer numbers faster than floating-point approaches. In this paper, we describe several methods for approximating a Gaussian filter, implement the SIMD and quantized versions, and compare them in terms of speed and accuracy. The experiments were performed on central processing units with a x86_64 architecture using a family of SSE SIMD extensions and an ARMv8 architecture using the NEON SIMD extension. All the optimized approximations demonstrated 10–20× speedup while maintaining the accuracy in the range of 1 × ${10}^{-5}$ or higher. The fastest method is a trivial Stack blur with a relatively high error, so we recommend using the second-order Vliet–Young–Verbeek filter and quantized Bell blur and running sums as more accurate and still computationally efficient alternatives. Full article

Orobanche aegyptiaca Pers. is a holoparasitic plant that severely reduces tomato (Solanum lycopersicum L.) production in China. However, there is a lack of effective control methods and few known sources of genetic resistance. In this study, we focused on key genes in the JAZ family, comparing the JAZ family in Arabidopsis thaliana (L. Heynh.) to the tomato genome. After identifying the JAZ family members in S. lycopersicum, we performed chromosomal localization and linear analysis with phylogenetic relationship analysis of the JAZ family. We also analyzed the gene structure of the JAZ gene family members in tomato and the homology of the JAZ genes among the different species to study their relatedness. The key genes for O. aegyptiaca resistance were identified using VIGS (virus-induced gene silencing), and the parasitization rate of silenced tomato plants against O. aegyptiaca increased by 47.23–91.13%. The genes were localized in the nucleus by subcellular localization. Heterologous overexpression in A. thaliana showed that the key gene had a strong effect on the parasitization process of O. aegyptiaca, and the overexpression of the key gene reduced the parasitization rate of O. aegyptiaca 1.69-fold. Finally, it was found that the SLJAZ15 gene can positively regulate the hormone content in tomato plants and affect plant growth and development, further elucidating the function of this gene. Full article

While considerable attention has been devoted to positive leadership patterns in the realm of project management, the dark side of leadership has rarely been studied within project teams. To address this gap, we focus on abusive supervision in project teams and develop a team-level moderated mediation model to examine whether, how, and when abusive supervision influences project outcomes by drawing from the Proactive Motivation Theory. Survey data were collected from 132 project teams containing 132 project managers and 392 project members using a multi-source time-lagged survey design. Our findings reveal significant negative relationships between abusive supervision and both project performance and project team creativity. Furthermore, we found that a team’s proactive behavior plays a mediating role in these relationships. More importantly, our study identifies that team building mitigates the direct negative impact of abusive supervision on proactive behavior and the indirect effects of abusive supervision on project performance and project team creativity. These findings provide valuable theoretical and managerial implications for abusive supervision and project management scholars and practitioners. Full article

This review article critically examines the pivotal role of chromatin organization in gene regulation, cellular differentiation, disease progression and aging. It explores the dynamic between the euchromatin and heterochromatin, coded by a complex array of histone modifications that orchestrate essential cellular processes. We discuss the pathological impacts of chromatin state misregulation, particularly in cancer and accelerated aging conditions such as progeroid syndromes, and highlight the innovative role of epigenetic therapies and artificial intelligence (AI) in comprehending and harnessing the histone code toward personalized medicine. In the context of aging, this review explores the use of AI and advanced machine learning (ML) algorithms to parse vast biological datasets, leading to the development of predictive models for epigenetic modifications and providing a framework for understanding complex regulatory mechanisms, such as those governing cell identity genes. It supports innovative platforms like CEFCIG for high-accuracy predictions and tools like GridGO for tailored ChIP-Seq analysis, which are vital for deciphering the epigenetic landscape. The review also casts a vision on the prospects of AI and ML in oncology, particularly in the personalization of cancer therapy, including early diagnostics and treatment optimization for diseases like head and neck and colorectal cancers by harnessing computational methods, AI advancements and integrated clinical data for a transformative impact on healthcare outcomes. Full article

The research on the significant toxic weed Oxytropis glabra, which adversely affects the grazing industry and the ecological integrity of natural grasslands in the arid and semi-arid regions of northern China, aims to delineate its potential distribution amidst changing climate conditions. This analysis involves both current conditions (1970–2000) and future projections (2050s and 2070s) under four climate scenarios using an R-optimized MaxEnt model. The results indicate that the distribution of O. glabra was primarily influenced by the temperature of the coldest quarter (bio11, ranging from −12.04 to −0.07 °C), precipitation of the coldest quarter (bio19, 0 to 15.17 mm), and precipitation of the warmest quarter (bio18, 0 to 269.50 mm). Currently, the weed predominantly occupies parts of Xinjiang, Inner Mongolia, Gansu, Qinghai, Ningxia, and Tibet. Projections indicate that, across four future climate scenarios, the area of suitable habitats for O. glabra is expected to expand and shift toward higher latitudes and elevations. The research provides valuable information and a theoretical foundation for the management of O. glabra, alongside advancing grassland ecological research and grazing practices. Full article

Cardiovascular disease (CVD) is the primary cause of death and disability worldwide. Although age-standardized CVD mortality rates decreased globally by 14.5% between 2006 and 2016, the burden of CVD remains disproportionately higher in low- and middle-income countries compared to high-income countries. Even though proven, effective approaches based on multiple-drug intake aimed at the prevention and treatment of CVD are currently available, poor adherence, early discontinuation of treatment, and suboptimal daily execution of the prescribed therapeutic regimes give rise to shortfalls in drug exposure, leading to high variability in the responses to the prescribed medications. Wald and Law, in their landmark paper published in BMJ 2003, hypothesized that the use of a fixed-dose combination of statins, β-blockers, angiotensin receptor blockers, angiotensin-converting enzyme inhibitors, and aspirin (classic Polypill composition) may increase adherence and decrease CVD by up to 80% when prescribed as primary prevention or in substitution of traditional protocols. Since then, many clinical trials have tested this hypothesis, with comparable results. This review aims to describe the available clinical trials performed to assess the impact of fixed-dose combinations on adherence, cost-effectiveness, and the risk factors critical to the onset of CVD. Full article

Among the conventional inks used for inkjet printing, metals, oxides, or polymers have been deposited in order to form functional coatings. Gold is one of the most used metals for electrode fabrication in the gas sensor field due to its inert behavior when exposed to reactive gases and conductive properties. However, only a few commercial gold inks are commercially available, and the combination of excessive price, a high minimum purchase quantity, and an unknown composition renders the actual products unappealing. To meet these shortcomings, gold inks were formulated with different solvents in order to reach sufficient properties for the inkjet printing process, such as surface tension and viscosity. On the one hand, gold ink was developed using a gold nanoparticle (AuNP) solution as the metal. This ink was optimized from nanoparticle synthesis, with the ink formulation obtaining a 32 mN·m⁻¹ surface tension and 11.2 mPa·s viscosity in order to be inkjet-printed onto polyimide foil. On the other hand, a particle-free ink, called a precursor based of ink, was also developed. In this case, ink was made by solubilizing gold salt in aqueous medium in order to reach jettable properties. Surface tension was measured at 32 mN·m⁻¹ while viscosity was 14.0 mPa·s. Then, printing and deposition parameters were optimized in order to obtain a highly conductive gold coating. The measured resistivity was 2 × 10⁻⁷ Ω·m which is close to the bulk gold conductive value. These coatings could be used for the fabrication of various devices in different working fields. Full article

This work analyzes the effect of wall geometry when a reaction–diffusion system is confined to a narrow channel. In particular, we study the entropy production density in the reversible Gray–Scott system. Using an effective diffusion equation that considers modifications by the channel characteristics, we find that the entropy density changes its value but not its qualitative behavior, which helps explore the structure-formation space. Full article

Obesity is an emerging threat and a current challenge for children and adolescents worldwide. The aim of the present work was to evaluate the relationship between the Dietary Antioxidant Index (DAI) and the weight status of students in early adolescence. A sample of 1580 students aged 10–12 years from 47 primary schools in Greece were enrolled. Anthropometric characteristics were assessed, and calculation of the Body Mass Index (BMI) was used to categorize students into two weight-status groups. Dietary habits and physical activity were evaluated using a self-completed questionnaire, and the DAI was calculated through derived micronutrients’ content, along with energy, macro-, and micro-nutrient intake. Crude and adjusted regression analysis showed a significant inverse association of the DAI and body weight status (Odds Ratio (OR): 0.719, 95% Confidence Interval (CI): 0.576; 0.897, and adjusted Odds Ration (aOR): 0.667, 95% CI: 0.489; 0.907). An antioxidant diet seems to play a protective role against increased body weight among students in early adolescence. Thus, dietary patterns rich in antioxidants should be promoted to facilitate healthy habits early in life, and to fight the obesity threat. Full article

Membrane bioreactors (MBRs) have gained attraction in municipal wastewater treatment because of their capacity to meet strict water quality standards and support water reuse. Despite this, their operational sustainability is often compromised by high resource consumption, especially regarding the use of chemicals for membrane cleaning. This study explores innovative membrane-cleaning strategies to enhance the sustainability of MBR processes. Through long-term pilot trials at Stockholm’s largest wastewater treatment plant, this study showed that alternative cleaning strategies can reduce chemical use by up to 75% without sacrificing treatment performance. The results further suggest that these alternative strategies could result in cost reductions of up to 70% and a reduction in environmental impacts by as much as 95% for certain indicators. Given that MBRs play a crucial role in addressing increasing treatment demands and advancing circular water management, the outcomes of this study are beneficial for the broader adoption of MBR processes. These results also have implications for existing installations, offering a pathway to more sustainable wastewater treatment. Moreover, the presented cleaning strategies provide significant opportunities for lowering operational costs and reducing the environmental footprint of new and existing MBR installations. Full article

In this paper, Cr (8 μm)/Ta (3 μm) bilayer coatings deposited on a Zr-1Nb alloy substrate were investigated and compared with a Cr-coated alloy under high-temperature steam oxidation at 1200–1400 °C. The bilayer coatings with α- and β-Ta interlayers were obtained by magnetron sputtering. The Cr/Ta-coated samples were studied using scanning electron microscopy (SEM), X-ray diffraction (XRD), and optical microscopy (OM). The coating with an α-Ta interlayer can suppress the interdiffusion of chromium and zirconium more effectively up to 1330 °C in comparison with the coating having a β-Ta interlayer. The weight gain of the α-Ta-coated samples after oxidation at 1200 °C for 2000 s was 5–6 times lower than that of the Cr-coated Zr alloy samples. Oxidation at 1400 °C for 120 s showed no significant difference in the weight gain of the Cr- and Cr/Ta-coated Zr-1Nb alloy samples. It was shown that the effect of suppression of Zr-Cr interdiffusion by the barrier coating (α- and β-Ta) is only short-term. Full article

Sickle cell disease is an orphan disease affecting ethnic minorities and characterized by profound systemic manifestations. Although around 100,000 individuals with SCD are living in the US, the exact number of individuals is unknown, and it is considered an orphan disease. This single-gene disorder leads to red blood cell sickling and the deoxygenation of hemoglobin, resulting in hemolysis. SCD is associated with acute complications such as vaso-occlusive crisis, infections, and chronic target organ complications such as pulmonary disease and renal failure. While genetic therapy holds promise to alter the fundamental disease process, the major challenge in the field remains the target end organ damage and ways to mitigate or reverse it. Here, we provide an overview of the clinical manifestations and pathogenesis with a focus on end-organ damage and current therapeutic options, including recent FDA-approved stem cell and gene editing therapies. Full article

Technological advancement has propelled global economic growth, but it has also led to high rates of pollution emissions, underscoring the urgency of environmental issues. The transportation sector, particularly the rise in individual vehicle ownership, significantly contributes to atmospheric pollution. In this context, Brazil faces growing challenges, largely due to the high number of individual motor vehicles. Transitioning to electric vehicles (EVs) is seen as a sustainable alternative to reduce emissions of polluting gases. However, it is important to consider that EVs may indirectly generate pollution due to energy production in thermal power plants. Nevertheless, EVs are often sought by countries to reduce dependence on imported fuels and to mitigate urban pollution. This study aims to understand the factors influencing the purchase decision of EVs in Brazil through a systematic literature review and validation by specialists using the fuzzy Delphi method. The results indicate 37 variables, grouped into five main blocks: psychological factors, performance factors, environmental factors, barriers, and prospects for the automotive sector. The validation of these variables by specialists provides a solid foundation for the next stage of the research, which involves administering the questionnaire to the general community. Considering these results will lead to strategies aimed at promoting EV adoption, in line with global sustainability challenges and the reduction in CO₂ emissions. Full article