Genome-wide association studies (GWAS) have successfully revealed numerous susceptibility loci for obesity. The PREDATORR study (2014) shows that in Romania, 346% of adults aged 20–79 y/o are overweight, and 31.4% are obese with a high risk of cardiometabolic complications, a number that puts almost 67% of Romania’s population in the abnormal weight group. Our study aims to investigate the current status of the genetic foundation in metabolic disease associated with obesity, applied to a pilot group of patients specifically examining the impact of known polymorphisms and their haplotype of six food intake-regulating genes, namely leptin (LEP), leptin receptor (LEP-R), serotonin receptor (5HTR2A), ghrelin (GHRL), neuropeptide Y (NPY), and fat-mass and obesity-associated protein (FTO) with the following polymorphisms: LEP A-2548G, LEPR A-223G, 5HTR2A G-1439A, GHRL G-72T, NPY T-29063C, FTO A-T, and body mass index (BMI). A notable link between the LEP-2548 rs7799039 gene’s AG genotype and the risk of obesity was observed, particularly pronounced in males aged 40–49, with an approximately seven-fold increased likelihood of obesity. The 5HTR2A rs6311 AA genotype was associated with a higher BMI, which was not statistically significant. The FTO rs9939609 gene’s AA genotype emerged as a significant predictor of obesity risk. Besides these significant findings, no substantial associations were observed with the LEPR, 5HTR2A, GHRL, and NPY genes. Haplotype association analysis showed a suggestive indication of GRGMLA (rs7799039, rs1137101, rs6311, rs696217, rs16139, rs9939609 sequence) haplotype with a susceptibility effect towards obesity predisposition. Linkage disequilibrium (LD) analysis showed statistically significant associations between LEP and LEPR gene (p = 0.04), LEP and GHRL gene (p = 0.0047), and GHRL and FTO gene (p = 0.03). Our study, to the best of our knowledge, is one of the very few on the Romanian population, and aims to be a starting point for further research on the targeted interventional strategies to reduce cardiometabolic risks. Full article

Background: Endometrial cancer is associated with changes in blood cell counts and with high levels of inflammatory markers, thus reflecting the tumor’s impact on various biological processes and suggesting their potential as biomarkers for endometrial cancer diagnosis, prognosis, and treatment response. The neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio in peripheral blood sampled preoperatively from patients have been reported to be independently associated with the prognosis of different types of malignancies. Objectives: This study aimed to compare several blood markers—red blood cells, white blood cells, platelet parameters, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, C-reactive protein, and fibrinogen—in patients with benign or malignant endometrial tumors. Material and methods: Our retrospective study included 670 patients (192 diagnosed with endometrial cancer and 478 with endometrial hyperplasia), and we compared the serological parameters discussed above with those sampled the day before surgery. Results: Analysis of complete blood count indices revealed no significant differences in red blood cell or total white blood cell parameters between the endometrial cancer group and the endometrial hyperplasia group. However, a distinct pattern emerged in the white blood cell differential. The endometrial cancer group showed a statistically significant decrease in lymphocyte count compared with the endometrial hyperplasia group. In contrast, the endometrial cancer group showed significantly higher mean platelet counts and increased mean platelet volume compared with controls. Furthermore, the endometrial cancer group demonstrated a marked inflammatory response, as evidenced by significantly elevated levels of C-reactive protein, fibrinogen, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio compared with the endometrial hyperplasia group. Conclusions: The current research revealed statistically significant differences in multiple serological biomarkers between the two groups. These findings support the initial hypothesis regarding the potential utility of these biomarkers in endometrial cancer diagnosis, prognosis, and treatment response, highlighting the existence of biomarkers affordable for analysis under any health system, regardless of the country’s level of development. Full article

Background: Oral health (OH) has evolved beyond dental concerns to encompass psychosocial dimensions and overall well-being. This study reviews OH strategies within a public health framework to identify key elements for effective OH promotion. Methods: A literature review following PRISMA guidelines identified 42 relevant articles from 62 screened. Five themes emerged: group-level, individual-level, policy-level (emphasizing devising OH policies), healthcare delivery, and communication. Common components included OH education, behaviour change, access to OH services, and policy integration. Results: Thematic analysis identified five overarching themes in oral health (OH) promotion strategies, with a focus on tailored approaches for specific populations and components such as education, access to services, interventions, and policy, emphasizing the multifaceted nature of OH promotion. Conclusion: Effective OH promotion requires a multifaceted approach and tailored strategies with interprofessional collaboration. Future research should focus on cost-effectiveness and user-friendly resources for OH professionals and policymakers. Full article

Over the years, the concentration of cadmium in soil has increased due to industrialization. Cadmium in the soil enters the human body through plant accumulation, seriously endangering human health. In the current study, two types of hydrogels were successfully synthesized using a free radical polymerization method: an ion-type hydrogel referred to as DMAPAA (N-(3-(Dimethyl amino) propyl) acrylamide)/DMAPAAQ (N,N-Dimethyl amino propyl acrylamide, methyl chloride quaternary) and a non-ion-type hydrogel known as DMAA (N,N-Dimethylacrylamide). In the experiment carried out in this study, the ion-type hydrogel DMAPAA/DMAPAAQ was introduced to cadmium-contaminated soil for vegetable cultivation. The study found that at cadmium levels of 0 and 2 mg/kg in soil, when exposed to a pH 2 solution, cadmium wasn’t detected in the filtrate using ICP. As the amount of cadmium increased to 500 mg/kg, hydrogel addition gradually reduced the filtrate cadmium concentration. Notably, the use of the 4% hydrogel resulted in 0 mg/L of cadmium. For the 0% hydrogel, vegetable cadmium absorption was determined to be 0.07 mg/g, contrasting with 0.03 mg/g for the 4% hydrogel. The DMAPAA/DMAPAAQ hydrogel significantly boosts vegetable growth by efficiently absorbing nitrate ions through ion exchange, releasing them for plant uptake. In contrast, the DMAA hydrogel, used as a control, does not enhance plant growth despite its water absorption properties. In summary, the composite hydrogel shows great potential for enhancing vegetable yield and immobilizing heavy metals in soil. Full article

The present study examined the impact of skill level on the integration of contextual prior information and kinematic information alongside post-error adjustment during action anticipation in basketball. Twenty-three collegiate basketball players and twenty-three control participants engaged in anticipating as quickly and accurately as possible the outcomes of free throws, utilizing video clips depicting basketball players’ actions, both with and without contextual prior information. Anticipatory performance and the difference in anticipatory performance following errors and correct responses were analyzed based on skill level and the congruency of contextual prior information (none, congruent, and incongruent). The findings revealed that the congruency of contextual prior information significantly affects action anticipation, with skill level moderating this effect. Moreover, skill level influenced the congruency effect on accuracy discrepancies between post-error and post-correct trials during action anticipation, with controls showing greater sensitivity to previous trial performance compared to experts. These results provide further evidence for the notion that individuals employ Bayesian reliability-based strategies to integrate different information sources and underscore the role of skill level in adjusting anticipatory judgments following errors during action anticipation. These insights contribute to a deeper understanding of the cognitive and behavioral mechanisms that differentiate skill levels in action anticipation, potentially guiding the development of targeted training interventions. Full article

This study explores the potential probiotic properties of yeasts isolated from various Chilean honeys, focusing on Ulmo, Quillay, and Mountain honeys. Six yeast strains were identified, including Zygosaccharomyces rouxii, Candida sp., Schizosaccharomyces pombe, Rhodosporidiobolus ruineniae, Clavispora lusitaniae, and Metschnikowia chrysoperlae. Phenotypic characterization involved assessing their fermentative performance, ethanol and hops resistance, and cross-resistance. Ethanol concentration emerged as a limiting factor in their fermentative performance. The probiotic potential of these yeasts was evaluated based on resistance to high temperatures, low pH, auto-aggregation capacity, survival in simulated in vitro digestion (INFOGEST method), and antimicrobial activity against pathogens like Escherichia coli, Staphylococcus aureus, and Salmonella enteritidis. Three yeasts, Zygosaccharomyces rouxii, Schizosaccharomyces pombe, and Metschnikowia chrysoperlae, exhibited potential probiotic characteristics by maintaining cell concentrations exceeding 10⁶ CFU/mL after in vitro digestion. They demonstrated fermentative abilities and resistance to ethanol and hops, suggesting their potential as starter cultures in beer production. Despite revealing promising probiotic and technological aspects, further research is necessary to ascertain their viability in producing fermented foods. This study underscores the innovative potential of honey as a source for new probiotic microorganisms and highlights the need for comprehensive investigations into their practical applications in the food industry. Full article

Alzheimer’s Disease (AD) presents a complex neuropathological landscape characterized by hallmark amyloid plaques and neurofibrillary tangles, leading to progressive cognitive decline. Despite extensive research, the molecular intricacies contributing to AD pathogenesis are inadequately understood. While single-cell omics technology holds great promise for application in AD, particularly in deciphering the understanding of different cell types and analyzing rare cell types and transcriptomic expression changes, it is unable to provide spatial distribution information, which is crucial for understanding the pathological processes of AD. In contrast, spatial multi-omics research emerges as a promising and comprehensive approach to analyzing tissue cells, potentially better suited for addressing these issues in AD. This article focuses on the latest advancements in spatial multi-omics technology and compares various techniques. Additionally, we provide an overview of current spatial omics-based research results in AD. These technologies play a crucial role in facilitating new discoveries and advancing translational AD research in the future. Despite challenges such as balancing resolution, increasing throughput, and data analysis, the application of spatial multi-omics holds immense potential in revolutionizing our understanding of human disease processes and identifying new biomarkers and therapeutic targets, thereby potentially contributing to the advancement of AD research. Full article

Lichens, a diverse group of organisms, have a unique structure consisting of fungal filaments and photosynthetic partner cells. This research conducted a comprehensive chemical analysis and evaluation of the anti-inflammatory and antioxidant properties of methanolic and acetone extracts from Umbilicaria crustulosa lichen, along with its isolated metabolites. The process involved separating atranorin and chloratranorin fractions, physodic acid, and gyrophoric acid. Secondary metabolites were identified using chromatographic and spectroscopic data. The total polyphenols content was determined spectrophotometrically. This study examined the antioxidant activity of extracts of the lichen U. crustulosa and the isolated fractions using three methods: DPPH scavenging activity, ABTS scavenging activity, and reducing power. This study also evaluated the acute oral toxicity and the anti-inflammatory activity of the extracts in Wistar albino rats. A higher content of the total phenolic compounds was found in the acetone extract, but antioxidant and anti-inflammatory activities were more prominent in the methanolic extract. The isolated atranorin and chloratranorin fractions and compound physodic acid showed the highest antioxidant activity. No toxic effects were noted in the acute oral toxicity study. This study highlights the potential of the investigated lichen as a valuable source of novel biological agents. Full article

This study aimed to verify whether there are differences in the body composition, functionality, lower-limb power, agility, and cardiorespiratory capacity in futsal players, comparing futsal athletes by competitive level. The athletes (N = 84) were divided into three groups: group Elite (N = 29), group Sub-Elite (N = 29), and group Non-Elite (N = 26). Anthropometric variables were analyzed through a bioimpedance scale (Inbody 270), and functionality was analyzed through a functional movement screen battery. The power of the lower limbs was tested with the Abalakov jump, the agility with the zigzag agility test, and the cardiorespiratory capacity through the futsal intermittent endurance test. Anthropometric data from futsal athletes revealed a homogeneity in relation to the variables analyzed, regardless of the level of competition in which they operate. In performance variables, the power of the members and functionality was considered a discriminating factor of the level of competitiveness of the athletes, with the Elite group athletes presenting the best values. We concluded that there were no differences in relation to the body composition of the athletes. However, the athletes of higher levels, as a rule, present better performances in physiological aspects, results that can be explained by the fact that there is a better periodization in terms of training, with more intense loads and more complex competitive calendars, thus resulting in a greater specialization of these athletes. Full article

Investigating the causes of Sudden cardiac death (SCD) is always difficult; in fact, genetic cardiac conditions associated with SCD could be “silent” even during autopsy investigation. In these cases, it is important to exclude other aetiology and assist to ask for genetic investigations. Herein, the purpose of this review is to collect the most-implicated genes in SCD and generate a panel with indications for first line and second line investigations. A systematic review of genetic disorders that may cause SCD in the general population was carried out according to the Preferred Reporting Item for Systematic Review (PRISMA) standards. We subsequently listed the genes that may be tested in the case of sudden cardiac death when the autopsy results are negative or with no evidence of acquired cardiac conditions. To make genetic tests more specific and efficient, it is useful and demanded to corroborate autopsy findings with the molecular investigation as evident in the panel proposed. The genes for first line investigations are HCM, MYBPC3, MYH7, TNNT2, TNNI3, while in case of DCM, the most implicated genes are LMNA and TTN, and in second line for these CDM, ACTN2, TPM1, C1QPB could be investigated. In cases of ACM/ARVC, the molecular investigation includes DSP, DSG2, DSC2, RYR2, PKP2. The channelopathies are associated with the following genes: SCN5A, KCNQ1, KCNH2, KCNE1, RYR2. Our work underlines the importance of genetic tests in forensic medicine and clinical pathology; moreover, it could be helpful not only to assist the pathologists to reach a diagnosis, but also to prevent other cases of SCD in the family of the descendant and to standardise the type of analysis performed in similar cases worldwide. Full article

Although China’s grain production has reached nineteen consecutive harvests, the uncertainty of the current domestic and international environment has put more pressure on further increasing grain production in the future. For the past few years, agricultural socialization services have been crucial in boosting grain production and farmers’ revenue by addressing the issue of land cultivation and farming methods. In this regard, the question of whether and how agricultural socialized services may resolve the present grain production conundrum is extremely practical. Therefore, the study employs the China Rural Revitalization Survey data of 3709 households. Based on the 2SLS model, stepwise regression method, and moderated effects model, it creatively takes into account a variety of agricultural production segments, investigates the mechanism of services on grain production from the standpoint of improved production efficiency and plot concentration, and further examines the effects of aging populations and regional variations in grain production areas. The study found the following: (1) The average proportion of grain production area of farmers in the sample is 49%, and 42% of farmers have purchased agricultural socialization services. (2) Agricultural socialization services can significantly promote farmers’ grain cultivation behavior by facilitating connected transfers in and inhibiting connected transfers out to take advantage of plot concentration, and boosting the use of agricultural machines to enhance output efficiency. (3) The aging of the agricultural population will, to a certain extent, strengthen the promoting effect of agricultural socialization services on grain cultivation. Agricultural socialization services affect grain cultivation more in main grain-producing areas. Therefore, emphasizing the role of agricultural socialization services in accelerating the shift to moderate-scale operations, decreasing the non-grain component of the planting structure, and promoting the implementation of policies tailored to actual production needs are important steps to safeguard the production capacity of grain in different regions. Full article

In the current century, urbanization and the development of the construction industry have led to the generation of construction and demolition waste (CDW), imposing pressure on ecology and the environment. This has attracted the attention of industry personnel and researchers. This work discusses the current research on recycled coarse or fine aggregate, mainly focusing on the physical, mechanical and durability properties of sustainable concrete with recycled coarse or fine aggregate. Furthermore, it also summarizes CDW recycling and classification in major countries, the production processes of recycled aggregate, and the physical properties. This review will provide a reference for the application of concrete with recycled coarse or fine aggregate. Moreover, this review notes that replacing natural aggregates with both coarse and fine recycled aggregates awaits further experimental exploration. Full article

The aim of this study was to show for the first time that low-frequency 3D-transmitted ultrasound tomography (3D UT, volography) can differentiate breast tissue types using tissue properties, accurately measure glandular and ductal volumes in vivo, and measure variation over time. Data were collected for 400 QT breast scans on 24 women (ages 18–71), including four (4) postmenopausal subjects, 6–10 times over 2+ months of observation. The date of onset of menopause was noted, and the cases were further subdivided into three (3) classes: pre-, post-, and peri-menopausal. The ducts and glands were segmented using breast speed of sound, attenuation, and reflectivity images and followed over several menstrual cycles. The coefficient of variation (CoV) for glandular tissue in premenopausal women was significantly larger than for postmenopausal women, whereas this is not true for the ductal CoV. The glandular standard deviation (SD) is significantly larger in premenopausal women vs. postmenopausal women, whereas this is not true for ductal tissue. We conclude that ducts do not appreciably change over the menstrual cycle in either pre- or post-menopausal subjects, whereas glands change significantly over the cycle in pre-menopausal women, and 3D UT can differentiate ducts from glands in vivo. Full article

The FDA has approved several drugs based on the fluorinated nucleoside pharmacophore, and numerous drugs are currently in clinical trials. Fluorine-containing nucleos(t)ides offer significant antiviral and anticancer activity. The insertion of a fluorine atom, either in the base or sugar of nucleos(t)ides, alters its electronic and steric parameters and transforms the lipophilicity, pharmacodynamic, and pharmacokinetic properties of these moieties. The fluorine atom restricts the oxidative metabolism of drugs and provides enzymatic metabolic stability towards the glycosidic bond of the nucleos(t)ide. The incorporation of fluorine also demonstrates additional hydrogen bonding interactions in receptors with enhanced biological profiles. The present article discusses the synthetic methodology and antiviral activities of FDA-approved drugs and ongoing fluoro-containing nucleos(t)ide drug candidates in clinical trials. Full article

This study examines the impact of corporate social responsibility (CSR) on labor investment efficiency utilizing a sample of China’s listed companies. The empirical results demonstrate that CSR improves labor investment efficiency, and the effect is significant in terms of both overinvestment and underinvestment. Findings from cross-sectional tests indicate that CSR has a more significant effect on labor investment efficiency in non-state-owned firms and firms with more financing constraints or higher labor adjustment costs. The conclusion is robust after utilizing a 2SLS regression, replacing indicators for labor investment efficiency and accounting for the impact of non-labor investment. In general, the results support stakeholder theory and confirm that CSR can enhance external monitoring and improve firms’ investment behavior. Full article

CO₂ geosequestration is an important contributor to United Nations Sustainable Development Goal 13, i.e., Climate Action, which states a global Net-Zero CO₂ emissions by 2050. A potential impact of CO₂ geosequestration in depleted oil and gas reservoirs is the variations in induced pressure across the caprocks, which can lead to significant local variations in CO₂ saturation. A detailed understanding of the relationship between the pressure gradient across the caprock and local CO₂ concentration is of utmost importance for assessing the potential of CO₂ geosequestration. Achieving this through experimental techniques is extremely difficult, and thus, we employ a coupled Computational Fluid Dynamics (CFD) and Finite Element Method (FEM) based solver to mimic sub-critical CO₂ injection in Opalinus Clay under various pressure gradients across the sample. The geomechanical and multiphase flow modelling utilising Darcy Law helps evaluate local variations in CO₂ concentration in Opalinus Clay. Well-validated numerical results indicate favourable sub-critical CO₂ geosequestration under a positive pressure gradient across Opalinus Clay. In the absence of a positive pressure gradient, a peak CO₂ concentration of 5% has been recorded, which increases substantially (above 90%) as the pressure gradient across the sample increases. Full article

(1) Background. Coeliac disease (CD) often co-occurs with autoimmune conditions or genetic syndromes, but there are few studies on the co-existence of CD and immunoglobulin E (IgE)-mediated allergies. The purpose of this study was to assess sensitization to food and aero-allergens in pediatric patients with CD. (2) Methods. A multiplex ALEX^®2 test was used to determine specific IgEs (sIgEs). (3) Results. The study included 108 children newly diagnosed with CD. Allergen extract- and/or allergen molecule-sIgEs were detected in 49.1% of children. Most children (41.5%) were sensitized to both inhalant and food allergens. The three most common aero-allergens (timothy pollen, ryegrass, silver birch) were molecules Phl p 1, Lol p 1, and Bet v 1. The most common food allergens (hazelnut, apple, and peanut) were Cor a 1, Mal d 1, and Ara h 8 molecules of the PR-10 subfamily. Patients were not sensitized to cereal allergens containing gluten. Spearman’s rank correlation analysis of sensitized patients showed a significant positive relationship (r = 0.31) between the patients’ age and the occurrence of positive sIgEs (≥0.3 kU_A/L) for inhalant allergen molecules (p = 0.045). In sensitized patients, mainly symptoms of inhalant allergy were observed, such as hay fever, conjunctivitis, and bronchial asthma. (4) Conclusions. The current study indicates the co-occurrence of IgE sensitization to food and inhalant allergens in children with CD. The study highlights the need to take a closer look at the diagnosis of IgE-mediated allergy in patients with CD, which may help in their care and lead to a better understanding of the relationship between CD and IgE-mediated allergy. Full article

As a major emitter of CO₂, China needs to take responsibility for slowing down global warming. In this paper, the potential carbon emission intensity of provinces is firstly calculated using the non-radial directional distance function under the group- and meta-frontier techniques, and then six scenarios based on two factors (economic development and carbon intensity) are set up to estimate the emission reduction potential of China and each province. Considering the goal of carbon neutrality, the calculation of CO₂ emission reduction potential quantifies the amount of emissions that can be reduced and the amount of emissions that should be balanced. Additionally, the degree of difficulty in achieving abatement potential is also calculated. The findings are as follows: First, assuming that the economic growth rate is reduced to 4.4% (achieving the second “100-year goal”) and each province adopts the most advanced low-carbon technologies, China could reduce carbon emissions by 5970.56 Mt compared to 2019 levels. To achieve net-zero emissions, the remaining 3824.2 Mt of carbon emissions should be removed by carbon reduction technologies. Second, the effect of slowing down economic growth and decreasing carbon intensity varies greatly among provinces. Hebei and Shandong should be prioritized as they have the greatest potential for emission reductions under both scenarios. Third, it is more difficult for Beijing, Shanghai, Hubei, Hunan, Inner Mongolia Autonomous Region, Chongqing, and Sichuan to achieve the abatement potential and they require more effort to reduce the same amount of carbon emissions compared to other provinces. The study provides a reference for achieving carbon neutrality and helps provinces to develop differentiated emission reduction strategies. Full article

This paper presents the Sustainability Compass as an emerging innovative bottom-up framework that promotes social learning about overall sustainability—i.e., human wellbeing and prosperity within environmental boundaries—by mean of its practical implementation in the PlanWise4Blue geoportal. The Sustainability Compass aims to put the theoretical idea of sustainability into practice by a systemic approach that continuously generates, refines and updates appropriate themes and metrics, through bottom-up enlarged participatory learning involving all researchers, entrepreneurs, environmental managers, and anyone else with an interest. Such inclusiveness promotes a common understanding of sustainability, cultivates a collective vision and facilitates the assessment of sustainability levels in different contexts, including national and regional planning efforts. The Sustainability Compass operationalises the generic, top-down and differently interpretable UN SDGs into more practical and bottom-up practice. This article outlines the finalised structure of the Sustainability Compass and presents its first application through case studies of cross-border aquaculture in Finland and Estonia, and a collaborative initiative in Finnish wind energy. Through detailed analysis of interviews and workshops, the article explains the empirical findings and offers a comprehensive guide to the use of the Sustainability Compass. This is exemplified by its integration with the PlanWise4Blue geoportal, demonstrating its practicality and effectiveness in real-world applications. Full article

Understanding and addressing the implications of extreme temperature-related events are critical under climate change, as they directly impact public health and strain energy infrastructure. This study delved into the critical assessment of deadly heat stress and extreme cold events in the Upper Midwestern United States (UMUS), from 1979 to 2021, recognizing the substantial and disparate impact these phenomena have on socially vulnerable communities. In the current study, the modified Mann–Kendall method was applied to understand the temporal trend of extreme heat stress, as well as extreme cold events, from 1979 to 2021 in the UMUS. The results showed that the average annual frequency of daytime extreme heat stress events was comparatively lower in the northern parts of the UMUS compared to the southern parts from 1979 to 2021. Furthermore, a significant increasing trend in daytime extreme heat stress was found in parts of Michigan, Wisconsin (around the lake region), Ohio, and lower parts of Indiana and Kentucky from 1979 to 2021. In contrast, a decreasing trend was noticed in western parts of the UMUS (parts of Minnesota, Iowa, and Missouri). A significant decreasing trend in extreme cold events was found throughout the UMUS from 1979 to 2021. However, an increasing trend was also noticed in Iowa and northern parts of Minnesota, Michigan, and Wisconsin. The results provide important insights for better understanding the unique risks posed by extreme temperature-related events, especially toward socially vulnerable communities in the UMUS, which is crucial for developing targeted interventions and fostering resilience in the face of escalating climate-related threats. Full article

This research was devoted to study the effect of the tacticity on the surface physicochemical properties of PMMA. (1) Background: The determination of the surface free energy of polymers is generally carried out by inverse gas chromatography (IGC) at infinite dilution. The dispersive, polar and surface acid-base properties of PMMA at different tacticities were obtained via IGC technique with the help of the net retention time and volume of adsorbed. (2) Methods: The London dispersion equation was used to quantify the polar free energy of adsorption, while the London dispersive surface energy ${\gamma }_s^d\left(T\right)$ of PMMAs was determined using the thermal model. (3) Results: The results showed non-linear variations of ${\gamma }_s^d\left(T\right)$ of atactic, isotactic, and syndiotactic PMMAs with three maxima characterizing the three transition temperatures of PMMAs. The obtained values of the enthalpic and entropic Lewis’s acid-base parameters showed that the basicity of the atactic PMMA was about four times larger than its acidity. (4) Conclusions: A large difference in the behavior of the various PMMAs was proven in the different values of the polar acid and base surface energies of the three PMMAs with an important effect of the tacticity of PMMA on its acid-base surface energies. Full article