The 2023 MDPI Annual Report has
been released!
 
Article
The Impact of Resistance Training on Equilibrium Abilities and Quality of Life in Older Adults after SARS-CoV-2 Survival
by Patrycja Bobowik, Jan Gajewski, Ida Wiszomirska, Agnieszka Maciejewska-Skrendo, Katarzyna Leźnicka and Katarzyna Kaczmarczyk
J. Clin. Med. 2024, 13(10), 2747; https://doi.org/10.3390/jcm13102747 (registering DOI) - 07 May 2024
Abstract
Background: The scientific literature on COVID-19 and its long-term impacts on all-body systems and their treatments is still limited. The aim of the study was to create a safe protocol-based intervention to improve functional and equilibrium abilities in older adults impacted by COVID-19. [...] Read more.
Background: The scientific literature on COVID-19 and its long-term impacts on all-body systems and their treatments is still limited. The aim of the study was to create a safe protocol-based intervention to improve functional and equilibrium abilities in older adults impacted by COVID-19. Methods: This study used a sample of 46 people (intervention group: n = 26; control group: n = 20). Resistance training (RT) was held twice a week, with 60 min per session for 8 weeks. The postural stability and quality of life questionnaire (WHQOOL) was completed during pre- and post-testing. Results: The results indicated significant differences in overall stability index (OSI) with eyes open (EO), anterior–posterior stability index (APSI) EO, fall-risk index 6-2 (FRI6-2) values in males (p < 0.05), and APSI EO (p < 0.05) values in females compared to control groups, respectively. In the training, a significant improvement was reported in OSI EO and APSI EO (p < 0.05) female groups compared to baseline results and in FRI6-2 values in both gender groups (p < 0.01—men, p < 0.05—women). The effect of the intervention was recorded in the intervention group in the OSI EO (Z = −3.12, p < 0.01, R = 0.533) and FRI6-2 (Z = −2.06, p < 0.05, R = 0.354). Additionally, significantly different reactions between the groups were observed in the psychological domain (DOM2) (Z = 2.194, p < 0.028, R = 0.389), social relationship domain (DOM3) (Z = 2.051, p < 0.0403, R = 0.361), and in question 2 concerning general health (Z = 3.309, p < 0.0009, R = 0.535). Conclusions: The findings indicate that RT had a positive effect on older adults affected by COVID-19, led to a significant improvement in their postural stability, and had a significant impact on elements of psychological well-being and quality of life. Full article
Article
Design and Additive Manufacturing of TPMS Heat Exchangers
by Jian Liu, David Cheng, Khin Oo, Ty-Liyiah McCrimmon and Shuang Bai
Appl. Sci. 2024, 14(10), 3970; https://doi.org/10.3390/app14103970 (registering DOI) - 07 May 2024
Abstract
Triply periodic minimal surface (TPMS) heat exchangers (HXs) have been investigated in this paper along with additive manufacturing (AM). Heat transfer coefficients, pressure drops, and thermal capacity were systematically evaluated as functions of wall thickness, lattice cell density, and materials. It turns out [...] Read more.
Triply periodic minimal surface (TPMS) heat exchangers (HXs) have been investigated in this paper along with additive manufacturing (AM). Heat transfer coefficients, pressure drops, and thermal capacity were systematically evaluated as functions of wall thickness, lattice cell density, and materials. It turns out that when thermal conductivity is above 100 W/m·K, gyroid HXs are less sensitive to variations in thickness and thermal conductivity. Additive manufacturing of 20 kW aluminum heat exchangers was successful and testing results are comparable with theoretical prediction. To the best of our knowledge, this is the first demonstration of a working prototype of TPMS HXs. Full article
(This article belongs to the Collection Additive Manufacturing of Metal Components)
Review
Advances in Extraction Protocols, Degradation Methods, and Bioactivities of Proanthocyanidins
by Lishan Liang, Yingjie Liu, Liyan Wu, Luo Weng, Honghao Qiu, Wenting Zhong and Fanxin Meng
Molecules 2024, 29(10), 2179; https://doi.org/10.3390/molecules29102179 (registering DOI) - 07 May 2024
Abstract
Proanthocyanidins, natural polyphenolic compounds abundantly present in plants, exhibit diverse bioactivities, including antioxidative, anti-inflammatory, and antibacterial effects. These bioactivities are intricately linked to the degree of polymerization of these compounds. Through a comprehensive analysis of recent domestic and international research, this article synthesizes [...] Read more.
Proanthocyanidins, natural polyphenolic compounds abundantly present in plants, exhibit diverse bioactivities, including antioxidative, anti-inflammatory, and antibacterial effects. These bioactivities are intricately linked to the degree of polymerization of these compounds. Through a comprehensive analysis of recent domestic and international research, this article synthesizes the latest advancements in the extraction process, degradation methods, as well as the biological activities and underlying mechanisms of proanthocyanidins. Furthermore, future research endeavors should prioritize the refinement of extraction techniques, the elucidation of bioactive mechanisms, and the development of formulations with enhanced potency. This will maximize the utilization of proanthocyanidins across diverse applications. Full article
(This article belongs to the Section Natural Products Chemistry)
Article
Toward Sustainable Global Product Development Performance: Exploring the Criticality of Organizational Factors and the Moderating Influence of Global Innovation Culture
by Razika Malek, Qing Yang and Sahraoui Dhelim
Sustainability 2024, 16(10), 3911; https://doi.org/10.3390/su16103911 (registering DOI) - 07 May 2024
Abstract
In today’s dynamic and global landscape, innovation and globalization are intricately linked drivers that propel modern businesses forward, serving as indispensable pillars upon which organizations heavily rely to maintain their competitive edge. Leveraging innovation within the context of global product development (GPD) practices [...] Read more.
In today’s dynamic and global landscape, innovation and globalization are intricately linked drivers that propel modern businesses forward, serving as indispensable pillars upon which organizations heavily rely to maintain their competitive edge. Leveraging innovation within the context of global product development (GPD) practices is imperative for organizations seeking to survive and effectively compete in the rapidly evolving marketplace. While preceding studies have primarily focused on the importance of individual and organizational capabilities, policies, and cultural factors in driving product development (PD) performance, they often overlook their interconnectedness within a global context. To address this gap, this study delves into the relationship between organizational factors and global product development performance (GPDP) while examining the moderating influence of global innovation culture (GIC). These organizational factors encompass technological innovation capabilities (TICs), team creativity (TC), dynamic capabilities (DCA), and competitive advantage (CA). Our hypothesis suggests a positive impact of these factors on GPD performance. Employing a structural equation modeling (SEM) approach through SMART-PLS 3, we analyzed data collected from 480 questionnaire forms distributed among registered global product development (GPD) organizations operating in China. The empirical findings underscore the significant influence of organizational factors on GPD performance, highlighting the critical role of global innovation culture in shaping these relationships. These insights shed light on the importance of establishing a harmonious balance between organizational culture and various factors to enhance interaction among organizational elements and optimize global product development performance. Ultimately, these efforts can lead to improvements in the overall effectiveness and sustained global product development. Full article
Review
Ca2+-Dependent Cl Channels in Vascular Tone Regulation during Aging
by Miriam Petrova, Monika Lassanova, Jana Tisonova and Silvia Liskova
Int. J. Mol. Sci. 2024, 25(10), 5093; https://doi.org/10.3390/ijms25105093 (registering DOI) - 07 May 2024
Abstract
Identifying alterations caused by aging could be an important tool for improving the diagnosis of cardiovascular diseases. Changes in vascular tone regulation involve various mechanisms, like NO synthase activity, activity of the sympathetic nervous system, production of prostaglandin, endothelium-dependent relaxing, and contracting factors, [...] Read more.
Identifying alterations caused by aging could be an important tool for improving the diagnosis of cardiovascular diseases. Changes in vascular tone regulation involve various mechanisms, like NO synthase activity, activity of the sympathetic nervous system, production of prostaglandin, endothelium-dependent relaxing, and contracting factors, etc. Surprisingly, Ca2+-dependent Cl channels (CaCCs) are involved in all alterations of the vascular tone regulation mentioned above. Furthermore, we discuss these mechanisms in the context of ontogenetic development and aging. The molecular and electrophysiological mechanisms of CaCCs activation on the cell membrane of the vascular smooth muscle cells (VSMC) and endothelium are explained, as well as the age-dependent changes that imply the activation or inhibition of CaCCs. In conclusion, due to the diverse intracellular concentration of chloride in VSMC and endothelial cells, the activation of CaCCs depends, in part, on intracellular Ca2+ concentration, and, in part, on voltage, leading to fine adjustments of vascular tone. The activation of CaCCs declines during ontogenetic development and aging. This decline in the activation of CaCCs involves a decrease in protein level, the impairment of Ca2+ influx, and probably other alterations in vascular tone regulation. Full article
(This article belongs to the Special Issue Aging in Cardiovascular Diseases)
20 pages, 5969 KiB  
Article
Ziziphus jujuba Miller Ethanol Extract Restores Disrupted Intestinal Barrier Function via Tight Junction Recovery and Reduces Inflammation
by Ye Jin Yang, Min Jung Kim, Ho Jeong Lee, Won-Yung Lee, Ju-Hye Yang, Hun Hwan Kim, Min Sup Shim, Ji Woong Heo, Jae Dong Son, Woo H. Kim, Gon Sup Kim, Hu-Jang Lee, Young-Woo Kim, Kwang Youn Kim and Kwang Il Park
Antioxidants 2024, 13(5), 575; https://doi.org/10.3390/antiox13050575 (registering DOI) - 07 May 2024
Abstract
Inflammatory bowel disease (IBD) is a chronic inflammatory condition caused by the disruption of the intestinal barrier. The intestinal barrier is maintained by tight junctions (TJs), which sustain intestinal homeostasis and prevent pathogens from entering the microbiome and mucosal tissues. Ziziphus jujuba Miller [...] Read more.
Inflammatory bowel disease (IBD) is a chronic inflammatory condition caused by the disruption of the intestinal barrier. The intestinal barrier is maintained by tight junctions (TJs), which sustain intestinal homeostasis and prevent pathogens from entering the microbiome and mucosal tissues. Ziziphus jujuba Miller (Z. jujuba) is a natural substance that has been used in traditional medicine as a therapy for a variety of diseases. However, in IBD, the efficacy of Z. jujuba is unknown. Therefore, we evaluated ZJB in Caco2 cells and a dextran sodium sulfate (DSS)-induced mouse model to demonstrate its efficacy in IBD. Z. jujuba extracts were prepared using 70% ethanol and were named ZJB. ZJB was found to be non-cytotoxic and to have excellent antioxidant effects. We confirmed its anti-inflammatory properties via the down-regulation of inflammatory factors, including inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). To evaluate the effects of ZJB on intestinal barrier function and TJ improvement, the trans-epithelial electrical resistance (TEER) and fluorescein isothiocyanate-dextran 4 kDa (FITC-Dextran 4) permeability were assessed. The TEER value increased by 61.389% and permeability decreased by 27.348% in the 200 μg/mL ZJB group compared with the 50 ng/mL IL-6 group after 24 h. Additionally, ZJB alleviated body weight loss, reduced the disease activity index (DAI) score, and induced colon shortening in 5% DSS-induced mice; inflammatory cytokines, tumor necrosis factor (TNF)-α, and interleukin (IL)-6 were down-regulated in the serum. TJ proteins, such as Zonula occludens (ZO)-1 and occludin, were up-regulated by ZJB in an impaired Caco2 mouse model. Additionally, according to the liquid chromatography results, in tandem with mass spectrometry (LC-MS/MS) analysis, seven active ingredients were detected in ZJB. In conclusion, ZJB down-regulated inflammatory factors, protected intestinal barrier function, and increased TJ proteins. It is thus a safe, natural substance with the potential to be used as a therapeutic agent in IBD treatment. Full article
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Review
Innovation Helps with Sustainable Business, Law, and Digital Technologies: Economic Development and Dispute Resolution
by Shumin Wang, Yincheng Li and Muhammad Bilawal Khaskheli
Sustainability 2024, 16(10), 3910; https://doi.org/10.3390/su16103910 (registering DOI) - 07 May 2024
Abstract
This paper discusses the dispute resolution procedure that innovative digital commerce has adopted for the future for sustainable business. As digital trade becomes increasingly important for economic growth, trade-related disputes must be settled in both business and consumer situations. This study examines the [...] Read more.
This paper discusses the dispute resolution procedure that innovative digital commerce has adopted for the future for sustainable business. As digital trade becomes increasingly important for economic growth, trade-related disputes must be settled in both business and consumer situations. This study examines the advantages of using digital technology to resolve disputes involving digital trade and discusses how digital technology is changing traditional dispute resolution procedures. Conventional trade disputes differ from their digital counterparts because the digital sphere gives rise to more complex trade conflicts that require stronger regulatory resources. The utilization of digital technologies such as blockchain, artificial intelligence, innovation-based models, digital strategies, and others can enhance the efficacy of conflict resolution. Digital technology can assist in resolving disputes with digital trade, even though procedural fairness issues including prejudice and algorithmic opacity may also arise. The research highlights the importance of developing innovative techniques to set up trade dispute resolution procedures and building legal frameworks for jurisdiction, trial, and enforcement procedures in addition to stressing the usage of digital technology. Full article
(This article belongs to the Special Issue Sustainability and Innovation in SMEs)
10 pages, 1404 KiB  
Article
Assessment of the Nasopalatine Canal Length and Shape Using Cone-Beam Computed Tomography: A Retrospective Morphometric Study
by Cristalle Soman
Diagnostics 2024, 14(10), 973; https://doi.org/10.3390/diagnostics14100973 (registering DOI) - 07 May 2024
Abstract
The anatomical position of the nasopalatine canal in the anterior maxilla makes it one of the most important vital structures in the region. Surgical and implant procedures in this area require local anesthesia to be administered. It is, therefore, important to morphologically assess [...] Read more.
The anatomical position of the nasopalatine canal in the anterior maxilla makes it one of the most important vital structures in the region. Surgical and implant procedures in this area require local anesthesia to be administered. It is, therefore, important to morphologically assess the length and shape of the nasopalatine canal for performing surgical procedures with more accuracy in this area. Cone-Beam Computed tomography scans were scrutinized using inclusion criteria of age 18 years and above, absence of any pathological lesions/fracture/surgery in the nasopalatine area, absence of orthodontic treatment or maxillary jaw correction surgeries, and exclusion criteria including CBCT scans with artifacts or error s in the area of interest, anterior implants, absence of bone diseases, trauma, surgeries, and impactions in the area of interest. A total of 360 scans were analyzed for the length and shape of the nasopalatine canals. The results of the study showed that the mean nasopalatine canal length was 12.51 mm. The hourglass shape of the canal was most common and had the highest representation in both genders, with male 80.62% and female 87.01%. A statistically significant difference (p < 0.001) was noted in nasopalatine canal length between males and females. The study provides insight into the significant association of gender with the canal’s shape and length of the canal. The length of the canal does not influence with age. These parameters are helpful for surgical planning and interventions in the anterior maxillary region. Full article
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Article
Electroencephalogram-Based ConvMixer Architecture for Recognizing Attention Deficit Hyperactivity Disorder in Children
by Min Feng and Juncai Xu
Brain Sci. 2024, 14(5), 469; https://doi.org/10.3390/brainsci14050469 (registering DOI) - 07 May 2024
Abstract
Attention deficit hyperactivity disorder (ADHD) is a neuro-developmental disorder that affects approximately 5–10% of school-aged children worldwide. Early diagnosis and intervention are essential to improve the quality of life of patients and their families. In this study, we propose ConvMixer-ECA, a novel deep [...] Read more.
Attention deficit hyperactivity disorder (ADHD) is a neuro-developmental disorder that affects approximately 5–10% of school-aged children worldwide. Early diagnosis and intervention are essential to improve the quality of life of patients and their families. In this study, we propose ConvMixer-ECA, a novel deep learning architecture that combines ConvMixer with efficient channel attention (ECA) blocks for the accurate diagnosis of ADHD using electroencephalogram (EEG) signals. The model was trained and evaluated using EEG recordings from 60 healthy children and 61 children with ADHD. A series of experiments were conducted to evaluate the performance of the ConvMixer-ECA. The results showed that the ConvMixer-ECA performed well in ADHD recognition with 94.52% accuracy. The incorporation of attentional mechanisms, in particular ECA, improved the performance of ConvMixer; it outperformed other attention-based variants. In addition, ConvMixer-ECA outperformed state-of-the-art deep learning models including EEGNet, CNN, RNN, LSTM, and GRU. t-SNE visualization of the output of this model layer validated the effectiveness of ConvMixer-ECA in capturing the underlying patterns and features that separate ADHD from typically developing individuals through hierarchical feature learning. These outcomes demonstrate the potential of ConvMixer-ECA as a valuable tool to assist clinicians in the early diagnosis and intervention of ADHD in children. Full article
Review
Chemiresistive Materials for Alcohol Vapor Sensing at Room Temperature
by Anna Maria Laera and Michele Penza
Chemosensors 2024, 12(5), 78; https://doi.org/10.3390/chemosensors12050078 (registering DOI) - 07 May 2024
Abstract
The development of efficient sensors able to detect alcoholic compounds has great relevance in many fields including medicine, pharmaceuticals, food and beverages, safety, and security. In addition, the measurements of alcohols in air are significant for environmental protection because volatile alcohols can have [...] Read more.
The development of efficient sensors able to detect alcoholic compounds has great relevance in many fields including medicine, pharmaceuticals, food and beverages, safety, and security. In addition, the measurements of alcohols in air are significant for environmental protection because volatile alcohols can have harmful effects on human health not only through ingestion, but also through inhalation or skin absorption. The analysis of alcohols in breath is a further expanding area, being employed for disease diagnoses. The analyses performed by using chromatography, mass-spectrometry, nuclear magnetic resonance, ultraviolet-visible spectroscopy, Fourier-transform infrared spectroscopy, or Raman spectroscopy often require complex sampling and procedures. As a consequence, many research groups have focused their efforts on the development of efficient portable sensors to replace conventional methods and bulky equipment. The ability to operate at room temperature is a key factor in designing portable light devices suitable for in situ real-time monitoring. In the present review, we provide a survey of the recent literature on the most efficient chemiresistive materials for alcohol sensing at room temperature. Remarkable gas-sensing performances have mainly been obtained by using metal oxides semiconductors (MOSs), metal organic frameworks (MOFs), 2D materials, and polymers. Among 2D materials, we mainly consider graphene-based materials, graphitic carbon nitride, transition metal chalcogenides, and MXenes. We discuss scientific advances and innovations published in the span of the last five years, focusing on sensing mechanisms. Full article
Article
Effects of Chlorinated Water on Neurite Length of Cultured Dorsal Root Ganglion Neurons and Semaphorin 3A Content of Cultured Epidermal Keratinocytes
by Kazuhisa Maeda, Neneka Okumura, Aoba Ogawa and Hatsumi Takeda
Cosmetics 2024, 11(3), 75; https://doi.org/10.3390/cosmetics11030075 (registering DOI) - 07 May 2024
Abstract
The tap water that we normally use contains certain concentrations of free residual chlorine to kill microorganisms and viruses and make it safe for use. Water containing free residual chlorine not only dries out our hair and skin but can also cause irritation [...] Read more.
The tap water that we normally use contains certain concentrations of free residual chlorine to kill microorganisms and viruses and make it safe for use. Water containing free residual chlorine not only dries out our hair and skin but can also cause irritation and itching in some people—especially those with sensitive skin or reduced skin barrier function. We investigated the effects of free residual chlorine on cultured dorsal root ganglion neurons and cultured epidermal keratinocytes. First, we measured neurite length in cultured rat dorsal root ganglion neurons. Next, to evaluate the effects of chlorine on semaphorin 3A (Sema3A) and nerve growth factor (NGF) levels in cultured human epidermal keratinocytes, we used an enzyme-linked immunosorbent assay to measure NGF in the supernatant and polymerase chain reaction and Western blot to determine Sema3A and NGF levels. Chlorine elongated the neurite length and increased the number of projections in cultured rat dorsal root ganglion neurons. Although there were no changes in NGF mRNA or protein levels in the supernatant of cultured human epidermal keratinocytes in the presence of chlorine, Sema3A mRNA and protein levels decreased, and the ratio of Sema3A to NGF was also reduced. Full article
(This article belongs to the Special Issue 10th Anniversary of Cosmetics—Recent Advances and Perspectives)
Article
Frequency Analysis of Asymmetric Circular Organic Solar Cells Embedded in an Elastic Medium under Hygrothermal Conditions
by Muneer Alali, Mohammad A. Abazid and Mohammed Sobhy
Symmetry 2024, 16(5), 577; https://doi.org/10.3390/sym16050577 (registering DOI) - 07 May 2024
Abstract
This research represents the first theoretical investigation about the vibration behavior of circular organic solar cells. Therefore, the vibration response of asymmetric circular organic solar cells that represent a perfect renewable energy source is demonstrated. For this purpose, the differential quadrature method (DQM) [...] Read more.
This research represents the first theoretical investigation about the vibration behavior of circular organic solar cells. Therefore, the vibration response of asymmetric circular organic solar cells that represent a perfect renewable energy source is demonstrated. For this purpose, the differential quadrature method (DQM) is employed. The organic solar cell is modeled as a laminated plate consisting of five layers of Al, P3HT:PCBM, PEDOT:PSS, ITO, and Glass. This cell is rested on a Winkler–Pasternak elastic foundation and assumed to be exposed to various types of hygrothermal loadings. There are three different kinds of temperature and moisture variations that are taken into account: uniform, linear, and nonlinear distribution throughout the cell’s thickness. The displacement field is presented based on a new inverse hyperbolic shear deformation theory considering only two unknowns. The motion equations including hygrothermal effect and plate–foundation interaction are established within the framework of Hamilton’s principle. The DQM is utilized to solve these equations. In order to ensure the accuracy of the proposed theory, the present results are compared with those reported by other higher-order theories. A comprehensive parametric illustration is conducted on the impacts of different parameters involving the geometrical configuration, elastic foundation parameters, temperature, and moisture concentration on the deduced eigenfrequency of the circular organic solar cells. Full article
(This article belongs to the Section Mathematics)
20 pages, 8014 KiB  
Article
Exploring Olive Pit Powder as a Filler for Enhanced Thermal Insulation in Epoxy Mortars to Increase Sustainability in Building Construction
by Veronica D’Eusanio, Andrea Marchetti, Stefano Pastorelli, Michele Silvestri, Lucia Bertacchini and Lorenzo Tassi
AppliedChem 2024, 4(2), 192-211; https://doi.org/10.3390/appliedchem4020013 - 07 May 2024
Abstract
This article explores the use of olive pit powder (OPP) as a promising resource for enhancing the thermal insulation properties of epoxy mortars. A comprehensive analysis of the chemical and physical characteristics of OPP was conducted, employing analytical techniques including scanning electron microscopy [...] Read more.
This article explores the use of olive pit powder (OPP) as a promising resource for enhancing the thermal insulation properties of epoxy mortars. A comprehensive analysis of the chemical and physical characteristics of OPP was conducted, employing analytical techniques including scanning electron microscopy (SEM), thermogravimetric analysis and emitted gas analysis (TG-MS-EGA), and proximal analysis. Experimental samples of epoxy grout were prepared by using different proportions of a conventional inorganic filler, quartz powder, and OPP within an epoxy mortar matrix. As the percentage of OPP in the formulation increased, the microstructure of the samples gradually became more porous and less compact. Consequently, there was a decrease in density with the increase in OPP content. The 28-day compressive strength decreased from 46 MPa to 12.8 MPa, respectively, in the samples containing only quartz (Sample E) and only OPP (Sample A) as a filler. Similarly, flexural strength decreased from 35.2 to 5.3 MPa. The thermal conductivity decreased from 0.3 W/mK in Sample E to 0.11 in Sample A. Therefore, increasing the %wt of OPP improved insulating properties while reducing the mechanical resistance values. This study highlights the potential of OPP as an environmentally friendly and thermally efficient filler for epoxy mortars, thereby promoting sustainable construction practices. Full article
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Review
Spiritual Distress, Hopelessness, and Depression in Palliative Care: Simultaneous Concept Analysis
by Helga Martins, Rita S. Silva, Joana Bragança, Joana Romeiro and Sílvia Caldeira
Healthcare 2024, 12(10), 960; https://doi.org/10.3390/healthcare12100960 (registering DOI) - 07 May 2024
Abstract
Spiritual distress, hopelessness, and depression are concepts that are often used in palliative care. A simultaneous concept analysis (SCA) of these concepts is needed to clarify the terminology used in palliative care. Therefore, the aim of this study is to conduct a SCA [...] Read more.
Spiritual distress, hopelessness, and depression are concepts that are often used in palliative care. A simultaneous concept analysis (SCA) of these concepts is needed to clarify the terminology used in palliative care. Therefore, the aim of this study is to conduct a SCA of spiritual distress, hopelessness, and depression in palliative care. A SCA was performed using the methodology of Haase’s model. A literature search was conducted in March 2020 and updated in April 2022 and April 2024. The search was performed on the following online databases: CINAHL with Full-Text, MEDLINE with Full-Text, MedicLatina, LILACS, SciELO, and PubMed. The search was achieved without restrictions on the date of publication. A total of 84 articles were included in this study. The results highlight that the three concepts are different but also share some overlapping points. Spiritual distress is embedded in the rupture of their spiritual/religious belief systems, a lack of meaning in life, and existential issues. Hopelessness is a sense of giving up and an inability to control and fix the patient’s situation. Finally, depression is a state of sadness with a multi-impaired situation. In conclusion, refining the three concepts in palliative care is essential since it promotes clarification and enhances knowledge development towards intervention. Full article
(This article belongs to the Section Nursing)
13 pages, 419 KiB  
Article
The Role of Coping Strategies in Children’s Repeated Suggestive Interviews
by Monia Vagni and Valeria Giostra
Forensic Sci. 2024, 4(2), 221-233; https://doi.org/10.3390/forensicsci4020015 - 07 May 2024
Abstract
Often in the forensic context, child victims and witnesses are interviewed several times, exposing them to suggestive questions and social pressures. The present study had the main purpose of verifying the effect of coping strategies on the levels of immediate suggestibility and on [...] Read more.
Often in the forensic context, child victims and witnesses are interviewed several times, exposing them to suggestive questions and social pressures. The present study had the main purpose of verifying the effect of coping strategies on the levels of immediate suggestibility and on the Resistant Behavioral Responses (RBRs) of children subjected to repeated suggestive interviews. A sample of 90 children, aged between 11 and 14, were administered the two parallel Gudjonsson Suggestibility Scales (GSS2 and GSS1) a few months apart and the Coping Inventory for Stressful Situations (CISS) to detect their coping strategies. The results showed that the avoidance coping increased suggestive vulnerability and reduced resistant responses. Task-oriented coping favored responses with greater source monitoring, which allow for the rejection of misleading information. Coping strategies did not show direct effects on the management of the socioemotional aspects involved in the suggestive interaction. After the negative feedback that invites children to be more accurate, a smaller effect of the avoidance strategy was recorded, indicating how actively requesting greater source monitoring can lead children to better recognize misleading information. Full article
(This article belongs to the Special Issue Abuse and Violence in Families)
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11 pages, 1413 KiB  
Article
Endoscopic Ultrasonography-Guided Fine-Needle Biopsy for Patients with Resectable Pancreatic Malignancies
by Ming-Sheng Chien, Ching-Chung Lin and Jian-Han Lai
Gastroenterol. Insights 2024, 15(2), 375-385; https://doi.org/10.3390/gastroent15020026 - 07 May 2024
Abstract
Clinicians often use endoscopic ultrasonography to survey pancreatic tumors. When endoscopists conduct this examination and find the tumor to be unresectable, a fine-needle biopsy is subsequently performed for tissue confirmation. However, if the tumor is deemed resectable, the necessity of a pre-operative fine-needle [...] Read more.
Clinicians often use endoscopic ultrasonography to survey pancreatic tumors. When endoscopists conduct this examination and find the tumor to be unresectable, a fine-needle biopsy is subsequently performed for tissue confirmation. However, if the tumor is deemed resectable, the necessity of a pre-operative fine-needle biopsy remains debatable. Therefore, we performed a retrospective analysis of a single-center cohort of patients with pancreatic tumors who underwent an endoscopic ultrasound-guided fine-needle biopsy or aspiration (EUS-FNB or FNA) between 2020 and 2022. This study focused on patients diagnosed with resectable malignant pancreatic tumors. The exclusion criteria included individuals diagnosed with benign pancreatic lesions and those with unresectable tumors. A total of 68 patients were enrolled in this study. Histological examination revealed that pancreatic adenocarcinoma was the predominant type of tumor (n = 42, 61.8%), followed by neuroendocrine tumors (n = 22, 32.3%), and metastasis (n = 4, 5.9%). Notably, 17 patients had a history of other cancers, with 23.5% being diagnosed with a metastatic tumor rather than primary pancreatic cancer. Therefore, EUS-FNA/FNB is crucial in patients with a resectable pancreatic tumor and a history of cancer to differentiate between a primary and a metastatic tumor. Full article
(This article belongs to the Section Pancreas)
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12 pages, 1167 KiB  
Article
Restoration of Lactobacillus johnsonii and Enterococcus faecalis Caused the Elimination of Tritrichomonas sp. in a Model of Antibiotic-Induced Dysbiosis
by Yulia Makusheva, Elena Goncharova, Victoria Bets, Anastasya Korel, Elena Arzhanova and Ekaterina Litvinova
Int. J. Mol. Sci. 2024, 25(10), 5090; https://doi.org/10.3390/ijms25105090 (registering DOI) - 07 May 2024
Abstract
Inflammatory bowel disease (IBD) is a multifactorial disease involving the interaction of the gut microbiota, genes, host immunity, and environmental factors. Dysbiosis in IBD is associated with pathobiont proliferation, so targeted antibiotic therapy is a rational strategy. When restoring the microbiota with probiotics, [...] Read more.
Inflammatory bowel disease (IBD) is a multifactorial disease involving the interaction of the gut microbiota, genes, host immunity, and environmental factors. Dysbiosis in IBD is associated with pathobiont proliferation, so targeted antibiotic therapy is a rational strategy. When restoring the microbiota with probiotics, it is necessary to take into account the mutual influence of co-cultivated microorganisms, as the microbiota is a dynamic community of species that mediates homeostasis and physiological processes in the intestine. The aim of our study was to investigate the recovery efficacy of two potential probiotic bacteria, L. johnsonii and E. faecalis, in Muc2−/− mice with impaired mucosal layer. Two approaches were used to determine the efficacy of probiotic supplementation in mice with dysbiosis caused by mucin-2 deficiency: bacterial seeding on selective media and real-time PCR analysis. The recovery time and the type of probiotic bacteria relocated affected only the number of E. faecalis. A significant positive correlation was found between colony-forming unit (CFU) and the amount of E. faecalis DNA in the group that was replanted with probiotic E. faecalis. As for L. johnsonii, it could be restored to its original level even without any additional bacteria supplementation after two weeks. Interestingly, the treatment of mice with L. johnsonii caused a decrease in the amount of E. faecalis. Furthermore, either L. johnsonii or E. faecalis treatment eliminated protozoan overgrowth caused by antibiotic administration. Full article
(This article belongs to the Special Issue Molecular Diagnosis and Treatment of Inflammatory Bowel Disease)
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11 pages, 2375 KiB  
Article
Seroprevalence of Herpes Simplex Virus Types 1 and 2 among Pregnant Women in South-Western Romania
by Cristiana Luiza Radoi, Oana Mariana Cristea, Dan Dumitru Vulcanescu, Adela Voinescu, Tiberiu Liviu Dragomir, Laurentiu Vasile Sima, Sonia Tanasescu, Octavia Oana Harich, Andrei Theodor Balasoiu, Dominic Gabriel Iliescu and Ovidiu Zlatian
Life 2024, 14(5), 596; https://doi.org/10.3390/life14050596 (registering DOI) - 07 May 2024
Abstract
Background: Pregnancy-related infections with the human herpes simplex virus (HSV) strains HSV-1 and HSV-2 are particularly noteworthy. There are numerous reported examples of intrapartum transmission of herpes infection, notwithstanding the extreme rarity of intrauterine transfer from mother to fetus. The purpose of this [...] Read more.
Background: Pregnancy-related infections with the human herpes simplex virus (HSV) strains HSV-1 and HSV-2 are particularly noteworthy. There are numerous reported examples of intrapartum transmission of herpes infection, notwithstanding the extreme rarity of intrauterine transfer from mother to fetus. The purpose of this study was to evaluate the seroprevalence of HSV-1 and HSV-2 antibodies in pregnant women in the western region of Romania. Methods: Pregnant women who presented for routine pregnancy monitoring at Romania’s County Clinical Emergency Hospital in Craiova between 2013 and 2016 and 2019 and 2022 were included in the study. In order to find anti-HSV-1/2 IgG antibodies, we conducted serological testing on the patients and gathered demographic information from them. Results: HSV-1 seroprevalence was shown to have declined in rural areas and increased in urban areas, with values between 2013 and 2016 being 89.30% and those between 2019 and 2022 being 84.96%, respectively. Women over 35 who were pregnant had the highest seroprevalence. The seroprevalence of HSV-2 decreased from 16.16% in 2013–2016 to 12.43% in 2019–2022, and both rural and urban areas continued to experience this declining trend. Similarly, pregnant women over 35 years old had the highest frequency of HSV-1 infections. Conclusions: Establishing educational programs and other actions to reduce the transmission rate and ultimately the prevalence of the disease can be made easier with knowledge about the seroprevalence of HSV-1 and HSV-2 infections. Full article
(This article belongs to the Section Epidemiology)
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8 pages, 215 KiB  
Communication
Ethical Considerations for Artificial Intelligence Applications for HIV
by Renee Garett, Seungjun Kim and Sean D. Young
AI 2024, 5(2), 594-601; https://doi.org/10.3390/ai5020031 - 07 May 2024
Abstract
Human Immunodeficiency Virus (HIV) is a stigmatizing disease that disproportionately affects African Americans and Latinos among people living with HIV (PLWH). Researchers are increasingly utilizing artificial intelligence (AI) to analyze large amounts of data such as social media data and electronic health records [...] Read more.
Human Immunodeficiency Virus (HIV) is a stigmatizing disease that disproportionately affects African Americans and Latinos among people living with HIV (PLWH). Researchers are increasingly utilizing artificial intelligence (AI) to analyze large amounts of data such as social media data and electronic health records (EHR) for various HIV-related tasks, from prevention and surveillance to treatment and counseling. This paper explores the ethical considerations surrounding the use of AI for HIV with a focus on acceptability, trust, fairness, and transparency. To improve acceptability and trust towards AI systems for HIV, informed consent and a Federated Learning (FL) approach are suggested. In regard to unfairness, stakeholders should be wary of AI systems for HIV further stigmatizing or even being used as grounds to criminalize PLWH. To prevent criminalization, in particular, the application of differential privacy on HIV data generated by data linkage should be studied. Participatory design is crucial in designing the AI systems for HIV to be more transparent and inclusive. To this end, the formation of a data ethics committee and the construction of relevant frameworks and principles may need to be concurrently implemented. Lastly, the question of whether the amount of transparency beyond a certain threshold may overwhelm patients, thereby unexpectedly triggering negative consequences, is posed. Full article
(This article belongs to the Special Issue Standards and Ethics in AI)
15 pages, 6034 KiB  
Article
Distributed-Drive Vehicle Lateral-Stability Coordinated Control Based on Phase-Plane Stability Region
by Jun Liu and Ang Dai
World Electr. Veh. J. 2024, 15(5), 202; https://doi.org/10.3390/wevj15050202 - 07 May 2024
Abstract
The lateral stability control of vehicles is one of the most crucial aspects of vehicle safety. This article introduces a coordinated-control strategy designed to enhance the handling stability of distributed-drive electric vehicles. The upper controller uses active front steering and direct yaw moment-control [...] Read more.
The lateral stability control of vehicles is one of the most crucial aspects of vehicle safety. This article introduces a coordinated-control strategy designed to enhance the handling stability of distributed-drive electric vehicles. The upper controller uses active front steering and direct yaw moment-control controllers designed based on sliding-mode control theory. The lower controller optimally allocates control inputs to the upper controller, considering factors such as load transfer and tire load rate. It divides the stability region by relying on the phase plane and develops a coordinated-control strategy based on the degree of deviation of the vehicle state from the stability region. The results of the simulation experiments demonstrate that the proposed control strategy effectively improves handling stability under extreme working conditions. Full article
(This article belongs to the Special Issue Intelligent Electric Vehicle Control, Testing and Evaluation)
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14 pages, 561 KiB  
Review
Clinical and Paraclinical Considerations Regarding ki67’s Role in the Management of Differentiated Thyroid Carcinoma—A Literature Review
by Claudiu Peștean, Alexandru Pavel and Doina Piciu
Medicina 2024, 60(5), 769; https://doi.org/10.3390/medicina60050769 - 07 May 2024
Abstract
Background and Objectives: The ki67 nuclear protein is a tool for diagnosis and prognosis in oncology that is used to evaluate cell proliferation. Differentiated thyroid carcinoma is usually a slow-growing neoplasm, the most common type being the papillary form. Some clinical and [...] Read more.
Background and Objectives: The ki67 nuclear protein is a tool for diagnosis and prognosis in oncology that is used to evaluate cell proliferation. Differentiated thyroid carcinoma is usually a slow-growing neoplasm, the most common type being the papillary form. Some clinical and pathological aspects may predict aggressive behaviour. There are reported cases of recurrence without clinico-pathological findings of aggressiveness. To obtain better predictions of the disease outcome in thyroid carcinoma, many immunohistochemical markers have been studied. The aim of this narrative literature review is to identify the benefits that ki67 may add to the management of patients with differentiated thyroid carcinoma, according to the latest evidence. Materials and Methods: We performed a search on the PubMed and Google Scholar databases using controlled vocabulary and keywords to find the most suitable published articles. A total number of sixty-eight items were identified, and five other articles were selected from other sources. After refining the selection, the inclusion criteria and exclusion criteria were applied, and a total number of twenty-nine articles were included in this literature review. Results and Discussion: The studies consist of retrospective studies (89.66%), case reports (6.9%) and literature reviews (3.45%), evaluating the role, implications and other parameters of ki67 as a diagnostic and/or prognostic tool. The statistical correlations between ki67 and other features were systematized as qualitative results of this review in order to improve the treatment strategies presented in the included articles. Conclusions: The included studies present converging data regarding most of the aspects concerning ki67. The ki67 proliferation index is a diagnostic/prognostic tool of interest in differentiated thyroid carcinoma and a good predictor of disease-free survival, disease recurrence and metastatic development. Prospective studies on large cohorts may add value for ki67 as a specific tool in the management strategy of differentiated thyroid carcinoma. Full article
(This article belongs to the Section Oncology)
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20 pages, 1348 KiB  
Review
Quality of Life of Dialysis Patients: Exploring the Influence of Membrane Hemocompatibility and Dialysis Practices on Psychosocial and Physical Symptoms
by Victoria Doan, Ahmed Shoker and Amira Abdelrasoul
J. Compos. Sci. 2024, 8(5), 172; https://doi.org/10.3390/jcs8050172 - 07 May 2024
Abstract
Hemodialysis (HD) is a life-sustaining membrane-based therapy that is essential for managing kidney failure. However, it can have significant physical and psychological effects on patients due to chronic or acute consequences related to membrane bioincompatibility. End-stage renal disease (ESRD) patients on hemodialysis have [...] Read more.
Hemodialysis (HD) is a life-sustaining membrane-based therapy that is essential for managing kidney failure. However, it can have significant physical and psychological effects on patients due to chronic or acute consequences related to membrane bioincompatibility. End-stage renal disease (ESRD) patients on hemodialysis have a high incidence of psychiatric illness, particularly depression and anxiety disorders, and poor quality of life has been observed. Dialysis can also lead to physical symptoms of its own, such as fatigue, loss of appetite, anemia, low blood pressure, and fluid overload, in addition to the symptoms associated with kidney failure. Therefore, this critical review aims to comprehensively understand the impact of dialysis membrane bioincompatibility and the use of varying molecular weight cut-off membranes on the physical and psychological symptoms experienced by dialysis patients. We analyzed the latest research on the correlation between major inflammatory biomarkers released in patients’ blood due to membrane incompatibility, as well as the critical influence of low levels of hemoglobin and vital proteins such as human serum albumin due to the use of high-cut-off membranes and correlated these factors with the physical and psychological symptoms experienced by dialysis patients. Furthermore, our study aims to provide valuable insights into the impact of dialysis on critical symptoms, higher hospitalization rates, and the quality of life of First Nations, as well as child and youth dialysis patients, in addition to diabetic dialysis patients. Our goal is to identify potential interventions aiming to optimize the dialysis membrane and minimize its negative effects on patients, ultimately improving their well-being and long-term outcomes. Full article
(This article belongs to the Section Biocomposites)
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13 pages, 3419 KiB  
Article
Utilization of Waste Marble and Bi2O3-NPs as a Sustainable Replacement for Lead Materials for Radiation Shielding Applications
by Khalid Alsafi, Mohamed A. El-Nahal, Wafa M. Al-Saleh, Haifa M. Almutairi, Esraa H. Abdel-Gawad and Mohamed Elsafi
Ceramics 2024, 7(2), 639-651; https://doi.org/10.3390/ceramics7020042 - 07 May 2024
Abstract
In an attempt to reutilize marble waste, a new approach is presented in the current study to promote its use in the field of shielding against ionizing radiation. In this study, we aimed to develop a novel and sustainable/eco-friendly lead-free radiation shielding material [...] Read more.
In an attempt to reutilize marble waste, a new approach is presented in the current study to promote its use in the field of shielding against ionizing radiation. In this study, we aimed to develop a novel and sustainable/eco-friendly lead-free radiation shielding material by improving artificial marble (AM) produced from marble waste combined with polyester by reinforcing it with bismuth oxide (Bi2O3) nanoparticles. Six samples of AM samples doped with different concentrations (0%, 5%, 10%, 15%, 20%, and 25%) of Bi2O3 nanoparticles were prepared. The linear attenuation coefficient (LAC) values were measured experimentally through the narrow beam method at different energies (0.0595 MeV, 0.6617 MeV, 1.1730 MeV, and 1.330 MeV) for all samples with various concentrations of Bi2O3. Radiological shielding parameters such as half value layer (HVL), tenth-value layer (TVL), and radiation shielding efficiency (RSE) were estimated and compared for all the different samples. The results prove that increasing the concentration of Bi2O3 leads to the enhancement of the radiation shielding properties of the AM as a shielding material. It was observed that as the energy increases, the efficiency of the samples falls. High energy dependence was found when calculating the HVL and TVL values of the samples, which increased with increases in the energy of the incident photons. A comparison between the sample with the most efficient gamma radiation attenuation capability (AM-25%), concrete, and lead was conducted, and a discussion regarding their radiation shielding properties is presented herein. The results show that the AM-25% sample is superior to the ordinary concrete over all the studied energy ranges, as evidenced by its significantly lower HVLs. On the contrary, lead is superior to the AM-25% sample over all the studied energy ranges owing to its unbeatable density as a shielding material. Overall, this new type of artificial marble has the potential to be used as a radiation shielding material at low- to medium-gamma energy regions, specifically in medical imaging and radiation therapy. Full article
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