The 2023 MDPI Annual Report has
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27 pages, 14563 KiB  
Article
Practical Estimation of Machine Tool Spindle Dynamics for Maintenance Decision Making
by Patrick Chin, Jose M. DePavia and Stephen C. Veldhuis
Appl. Sci. 2024, 14(10), 4266; https://doi.org/10.3390/app14104266 (registering DOI) - 17 May 2024
Abstract
Condition-based maintenance of a machine tool spindle unit is known to reduce the total cost of operation in a manufacturing environment. However, standard vibration monitoring thresholds, which are based only on average vibration energy levels, do not account for the machine’s dynamics, such [...] Read more.
Condition-based maintenance of a machine tool spindle unit is known to reduce the total cost of operation in a manufacturing environment. However, standard vibration monitoring thresholds, which are based only on average vibration energy levels, do not account for the machine’s dynamics, such as dynamic stiffness and damping ratios, which, ultimately, control the final quality of a machined workpiece. In this study, a new mechanical device is proposed for the estimation of spindle dynamics characteristics through measurement of the frequency response function (FRF) of the spindle. The device is simple, robust in a manufacturing environment, small, and requires no power source. The new device is shown to be comparable in performance to conventional impact hammer testing, with the advantage of being fully automated and capable of dynamic assessment on a rotating spindle. Such a device allows a machine tool operator to routinely monitor the stiffness and damping ratios of the spindle unit and make informed maintenance decisions based on meaningful changes in operating conditions that impact production. Full article
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22 pages, 604 KiB  
Article
XplAInable: Explainable AI Smoke Detection at the Edge
by Alexander Lehnert, Falko Gawantka, Jonas During, Franz Just and Marc Reichenbach
Big Data Cogn. Comput. 2024, 8(5), 50; https://doi.org/10.3390/bdcc8050050 (registering DOI) - 17 May 2024
Abstract
Wild and forest fires pose a threat to forests and thereby, in extension, to wild life and humanity. Recent history shows an increase in devastating damages caused by fires. Traditional fire detection systems, such as video surveillance, fail in the early stages of [...] Read more.
Wild and forest fires pose a threat to forests and thereby, in extension, to wild life and humanity. Recent history shows an increase in devastating damages caused by fires. Traditional fire detection systems, such as video surveillance, fail in the early stages of a rural forest fire. Such systems would see the fire only when the damage is immense. Novel low-power smoke detection units based on gas sensors can detect smoke fumes in the early development stages of fires. The required proximity is only achieved using a distributed network of sensors interconnected via 5G. In the context of battery-powered sensor nodes, energy efficiency becomes a key metric. Using AI classification combined with XAI enables improved confidence regarding measurements. In this work, we present both a low-power gas sensor for smoke detection and a system elaboration regarding energy-efficient communication schemes and XAI-based evaluation. We show that leveraging edge processing in a smart way combined with buffered data samples in a 5G communication network yields optimal energy efficiency and rating results. Full article
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20 pages, 728 KiB  
Article
Preliminary Results of the Impact of Beneficial Soil Microorganisms on Okra Plants and Their Polyphenol Components
by Alaa Abdulkadhim A. Almuslimawi, Lívia László, Alhassani Leith Sahad, Ahmed Ibrahim Alrashid Yousif, György Turóczi and Katalin Posta
Agriculture 2024, 14(5), 776; https://doi.org/10.3390/agriculture14050776 (registering DOI) - 17 May 2024
Abstract
Okra (Abelmoschus esculentus L.) is a highly nutritious vegetable rich in vitamins, minerals, and bioactive compounds, including polyphenols, offering numerous health benefits. Despite its nutritional value, okra remains underutilized in Europe; however, its cultivation and popularity may rise in the future with [...] Read more.
Okra (Abelmoschus esculentus L.) is a highly nutritious vegetable rich in vitamins, minerals, and bioactive compounds, including polyphenols, offering numerous health benefits. Despite its nutritional value, okra remains underutilized in Europe; however, its cultivation and popularity may rise in the future with increasing awareness of its advantages. In agricultural practices, beneficial soil microorganisms, such as arbuscular mycorrhizal fungi (AMF), Trichoderma spp., Streptomyces spp., and Aureobasidium spp., play crucial roles in promoting plant health, enhancing agricultural productivity together with improved crop nutritional value. This study aimed to investigate the effects of individual and combined inoculation on the polyphenol content of okra fruits, as analyzed by HPLC. Moreover, growth parameters and glutathione-S-transferase enzyme (GST) activities of okra leaves were also estimated. Tested microorganisms significantly increased the yield of okra plants except for A. pullulans strain DSM 14950 applied individually. All microorganisms led to increased GST enzyme activity of leaves, suggesting a general response to biotic impacts, with individual inoculation showing higher enzyme activity globally compared to combined treatments. According to the polyphenol compound analysis, the application of tested microorganisms held various but generally positive effects on it. Only the combined treatment of F. mosseae and Streptomyces strain K61 significantly increased the coumaric acid content, and the application of Aureobasidium strain DSM 14950 had a positive influence on the levels of quercetin and quercetin-3-diglucoside. Our preliminary results show how distinct polyphenolic compound contents can be selectively altered via precise inoculation with different beneficial microorganisms. Full article
(This article belongs to the Special Issue Beneficial Microbes for Sustainable Crop Production)
13 pages, 5362 KiB  
Article
Enhanced H2 Generation via Piezoelectric Reforming of Waste Sugars and Fruits Using Au-Decorated g-C3N4
by Ke Ren, Fangjie Ding, Lijun Zhang, Fengping Peng, Jianzhong Guo and Chunzheng Wu
Sustainability 2024, 16(10), 4231; https://doi.org/10.3390/su16104231 (registering DOI) - 17 May 2024
Abstract
The food industry is responsible for generating considerable amounts of waste, such as excess fruits and leftover sugars, which contribute to resource depletion and pose environmental challenges. This research delves into the application of gold-modified graphitic carbon nitride nanosheets (Au/CN) as a potent [...] Read more.
The food industry is responsible for generating considerable amounts of waste, such as excess fruits and leftover sugars, which contribute to resource depletion and pose environmental challenges. This research delves into the application of gold-modified graphitic carbon nitride nanosheets (Au/CN) as a potent catalyst for the transformation of these food wastes into H2 via piezoelectric reforming during sonication. Au/CN demonstrated a superior rate of H2 evolution compared to pristine g-C3N4 (i.e., 1533.3 vs. 364.9 µmol/g/h) and it maintained its efficiency through multiple cycles of use. The catalytic activity was found to be optimal at a neutral pH level and with increased sugar concentrations. The enhanced catalytic performance of Au/CN was ascribed to the efficient segregation of charge carriers as well as the reduced charge transfer distance. This study underscores the viability of using Au/CN as a means for converting food wastes into a sustainable source of H2 energy. Full article
15 pages, 659 KiB  
Article
Disease Control and Treatment Satisfaction in Patients with Chronic Spontaneous Urticaria in Japan
by Atsushi Fukunaga, Yuko Kishi, Kazuhiko Arima and Hiroyuki Fujita
J. Clin. Med. 2024, 13(10), 2967; https://doi.org/10.3390/jcm13102967 (registering DOI) - 17 May 2024
Abstract
Background: Chronic spontaneous urticaria (CSU), characterized by the recurrence of pruritic hives and/or angioedema for >6 weeks with no identifiable trigger, has a negative impact on health-related quality of life (HRQoL). Methods: The objective of this web-based cross-sectional study was to evaluate disease [...] Read more.
Background: Chronic spontaneous urticaria (CSU), characterized by the recurrence of pruritic hives and/or angioedema for >6 weeks with no identifiable trigger, has a negative impact on health-related quality of life (HRQoL). Methods: The objective of this web-based cross-sectional study was to evaluate disease control, disease burden, and treatment satisfaction in Japanese adults with CSU using the Urticaria Control Test (UCT), HRQoL outcomes, and the Treatment Satisfaction Questionnaire for Medication–9 items (TSQM-9). Results: In total, 529 adults were included in the analysis (59.9% female), with a mean ± standard deviation (SD) in CSU duration of 13.2 ± 13.0 years. Based on UCT scores, two-thirds of patients had poor (score of 0–7; 23.6%) or insufficient (score of 8–11; 43.3%) symptom control, and one-third had good control (score of 12–16; 33.1%). Overall treatment satisfaction was not high, with mean ± SD TSQM-9 scores of 55.5 ± 17.6% for effectiveness, 68.2 ± 18.8% for convenience, and 59.2 ± 18.4% for global satisfaction. No apparent differences in TSQM-9 scores were observed between patients receiving different medications. HRQoL outcomes were worse among patients with poor/insufficient symptom control. Conclusions: Japanese adults with CSU have a high disease burden, and better treatment options are needed to increase treatment satisfaction. Full article
(This article belongs to the Special Issue Chronic Inflammatory Skin Diseases: An Update for Clinician—Part II)
21 pages, 867 KiB  
Article
Enhancing Secondary Metabolite Production in Pelargonium graveolens Hort. Cell Cultures: Eliciting Effects of Chitosan and Jasmonic Acid on Bioactive Compound Production
by Amine Elbouzidi, Mohamed Taibi, Abdellah Baraich, Mounir Haddou, El Hassania Loukili, Abdeslam Asehraou, François Mesnard and Mohamed Addi
Horticulturae 2024, 10(5), 521; https://doi.org/10.3390/horticulturae10050521 (registering DOI) - 17 May 2024
Abstract
This study explores the effects of chitosan (CHT) and jasmonic acid (JA) elicitors on rose-scented geranium (Pelargonium graveolens Hort.) cell suspension cultures, aiming to enhance the production of phenolics and flavonoids and antioxidant properties. Elicitation with CHT and JA resulted in varied [...] Read more.
This study explores the effects of chitosan (CHT) and jasmonic acid (JA) elicitors on rose-scented geranium (Pelargonium graveolens Hort.) cell suspension cultures, aiming to enhance the production of phenolics and flavonoids and antioxidant properties. Elicitation with CHT and JA resulted in varied biomass yields and callus characteristics, with higher concentrations generally leading to increased phenolic accumulation. Optimal biomass was achieved with CHT4 (75 mg/mL) and JA3 (50 µM) treatments. HPLC-DAD analysis revealed changes in phenolic compound composition and quantities, with specific compounds induced by either CHT4 or JA3. For instance, gallic acid content increased significantly in CHT4-treated cells, while catechin content increased notably in both CHT4 and JA3 treatments. Antioxidant enzyme activities like superoxide dismutase and peroxidase increased with elicitor concentration, particularly in CHT4 and JA3 treatments. Both treatments exhibited potent antioxidant activity, with JA3 exhibiting the lowest IC50 value in the DPPH assay and highest total antioxidant capacity (TAC) values. Surprisingly, both CHT4 and JA3 extracts effectively inhibited tyrosinase activity. These findings underscore the efficacy of CHT and JA elicitors in enhancing phenolic and flavonoid production, boosting antioxidant capacity, and inhibiting tyrosinase activity in P. graveolens cultures, offering promising implications for further research and industrial applications in pharmaceutical and cosmetic sectors. Full article
21 pages, 4277 KiB  
Article
The Mitochondrial-Derived Peptide MOTS-c Alleviates Radiation Pneumonitis via an Nrf2-Dependent Mechanism
by Yanli Zhang, Jianfeng Huang, Yaru Zhang, Fengjuan Jiang, Shengpeng Li, Shuai He, Jiaojiao Sun, Dan Chen, Ying Tong, Qingfeng Pang and Yaxian Wu
Antioxidants 2024, 13(5), 613; https://doi.org/10.3390/antiox13050613 (registering DOI) - 17 May 2024
Abstract
Radiation pneumonitis (RP) is a prevalent and fatal complication of thoracic radiotherapy due to the lack of effective treatment options. RP primarily arises from mitochondrial injury in lung epithelial cells. The mitochondrial-derived peptide MOTS-c has demonstrated protective effects against various diseases by mitigating [...] Read more.
Radiation pneumonitis (RP) is a prevalent and fatal complication of thoracic radiotherapy due to the lack of effective treatment options. RP primarily arises from mitochondrial injury in lung epithelial cells. The mitochondrial-derived peptide MOTS-c has demonstrated protective effects against various diseases by mitigating mitochondrial injury. C57BL/6 mice were exposed to 20 Gy of lung irradiation (IR) and received daily intraperitoneal injections of MOTS-c for 2 weeks. MOTS-c significantly ameliorated lung tissue damage, inflammation, and oxidative stress caused by radiation. Meanwhile, MOTS-c reversed the apoptosis and mitochondrial damage of alveolar epithelial cells in RP mice. Furthermore, MOTS-c significantly inhibited oxidative stress and mitochondrial damage in MLE-12 cells and primary mouse lung epithelial cells. Mechanistically, MOTS-c increased the nuclear factor erythroid 2-related factor (Nrf2) level and promoted its nuclear translocation. Notably, Nrf2 deficiency abolished the protective function of MOTS-c in mice with RP. In conclusion, MOTS-c alleviates RP by protecting mitochondrial function through an Nrf2-dependent mechanism, indicating that MOTS-c may be a novel potential protective agent against RP. Full article
16 pages, 607 KiB  
Article
The Storage Process of Electric Energy Produced from Renewable Sources from Hydrogen to Domestic Hot Water Heating
by Dorel Stoica, Lucian Mihăescu, Gheorghe Lăzăroiu and George Cristian Lăzăroiu
Processes 2024, 12(5), 1024; https://doi.org/10.3390/pr12051024 (registering DOI) - 17 May 2024
Abstract
The expansion of renewable electricity storage technologies, including green hydrogen storage, is spurred by the need to address the high costs associated with hydrogen storage and the imperative to increase storage capacity. The initial section of the paper examines the intricacies of storing [...] Read more.
The expansion of renewable electricity storage technologies, including green hydrogen storage, is spurred by the need to address the high costs associated with hydrogen storage and the imperative to increase storage capacity. The initial section of the paper examines the intricacies of storing electricity generated from renewable sources, particularly during peak periods, through green hydrogen. Two primary challenges arise: firstly, the complexity inherent in the storage technology and its adaptation for electricity reproduction; and secondly, the cost implications throughout the technological chain, resulting in a significant increase in the price of the reproduced energy. Electric energy storage emerges as a pivotal solution to accommodate the growing proportion of renewable energy within contemporary energy systems, which were previously characterized by high stability. During the transition to renewable-based energy systems, optimizing energy storage technology to manage power fluctuations is crucial, considering both initial capital investment and ongoing operational expenses. The economic analysis primarily focuses on scenarios where electricity generated from renewable sources is integrated into existing power grids. The subsequent part of this paper explores the possibility of localizing excess electricity storage within a specific system, illustrated by domestic hot water. Full article
(This article belongs to the Section Energy Systems)
23 pages, 16746 KiB  
Article
Analysis of Soil Slope Stability under Underground Coal Seam Mining Using Improved Radial Movement Optimization with Lévy Flight
by Haotian Li, Liangxing Jin and Pingting Liu
Mathematics 2024, 12(10), 1566; https://doi.org/10.3390/math12101566 (registering DOI) - 17 May 2024
Abstract
Underground coal seam mining significantly reduces the stability of slopes, especially soil slopes, and an accurate evaluation of the stability of soil slopes under underground mining conditions is crucial for mining safety. In this study, the impact of coal seam mining is considered [...] Read more.
Underground coal seam mining significantly reduces the stability of slopes, especially soil slopes, and an accurate evaluation of the stability of soil slopes under underground mining conditions is crucial for mining safety. In this study, the impact of coal seam mining is considered as the additional horizontal and vertical stresses acting on the slope, and an equation for calculating the safety factor of soil slopes under underground mining conditions is derived based on the rigorous Janbu method. Then, the Improved Radial Movement Optimization (IRMO) algorithm is introduced and combined with Lévy flight optimization to conduct global optimization searches, obtaining the critical sliding surface and corresponding safety factor of the soil slope under underground coal seam mining. Through comparisons with the numerical simulation results in three different case studies, the feasibility of applying the IRMO algorithm with Lévy flight to analyze the stability of soil slopes under underground mining is demonstrated. This ensures the accuracy and stability of the calculation results while maintaining a high convergence efficiency. Furthermore, the effects of the mining thickness and mining direction on slope stability are analyzed, and the results indicate that a smaller mining thickness and mining along the slope are advantageous for slope stability. The method proposed in this study provides valuable insights for preventing the slope instability hazards caused by underground coal seam mining. Full article
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34 pages, 22821 KiB  
Article
An Innovative System for Enhancing Archaeological In Situ Excavation through Geospatial Integration
by Asimina Dimara, Sotirios Tsakiridis, Doukas Psarros, Alexios Papaioannou, Dimitrios Varsamis, Christos-Nikolaos Anagnostopoulos and Stelios Krinidis
Heritage 2024, 7(5), 2586-2619; https://doi.org/10.3390/heritage7050124 (registering DOI) - 17 May 2024
Abstract
The field of archaeological excavation has seen enormous developments as a result of the quick development of digital technologies. It is critical to acknowledge the long-term benefits of new approaches. In this regard, this study intends to suggest a system that provides archaeologists [...] Read more.
The field of archaeological excavation has seen enormous developments as a result of the quick development of digital technologies. It is critical to acknowledge the long-term benefits of new approaches. In this regard, this study intends to suggest a system that provides archaeologists with digital tools that allow them to fully and effectively document their excavations in real time while in the field, which is specifically designed for classical and Byzantine archaeology. The system not only facilitates traditional documentation practices but also integrates advanced geospatial technologies and augmented reality, enhancing the accuracy and depth of archaeological research and preservation. This dual functionality enables both the efficient recording of excavation data as experienced by excavators on-site and the detailed documentation processed by researchers post-excavation. The objective of the application is to generate a sophisticated system that will enable the excavation data and experience that the excavator gains on the site of work to be recorded in real time, as well as the documentation that is subsequently processed and accomplished by the researcher or by other researchers. The system saves detailed images and 3D models of artifacts and excavation sites. This ensures that every detail is recorded while preserving the data for future analysis and reference. Lastly, the application was tested in realistic use case scenarios and real-world settings, which increased the system’s credibility and demonstrated its capability to enhance the procedures involved in archaeological excavation and documentation. Full article
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27 pages, 1777 KiB  
Article
Reinforcement Effects on Tensile Behavior of Ultra-High-Performance Concrete (UHPC) with Low Steel Fiber Volume Fractions
by Xianzhi Luo, Sumei Zhang, Aidong Li, Chenming Zhang and Yuchen Zhang
Materials 2024, 17(10), 2418; https://doi.org/10.3390/ma17102418 (registering DOI) - 17 May 2024
Abstract
Ultra-high-performance concrete (UHPC) with a low steel fiber volume fraction offers lower material costs than UHPC with typical steel fiber volume fractions, and has the potential to mitigate the ductility degradation of rebar-reinforced UHPC (R-UHPC). This study explores the reinforcement effect on the [...] Read more.
Ultra-high-performance concrete (UHPC) with a low steel fiber volume fraction offers lower material costs than UHPC with typical steel fiber volume fractions, and has the potential to mitigate the ductility degradation of rebar-reinforced UHPC (R-UHPC). This study explores the reinforcement effect on the tensile behavior of UHPC with a low fiber volume fraction with the aim of facilitating more cost-efficient UHPC applications. The axial tensile behavior of 30 UHPC specimens with low fiber volume fractions at different reinforcement ratios was tested through direct tensile tests. The findings indicate that adopting UHPC with a low fiber volume fraction can significantly mitigate the ductility deterioration of rebar-reinforced UHPC (R-UHPC), and both increasing the reinforcement ratio and decreasing the fiber volume fraction contribute to the improvement in ductility. The failure modes of R-UHPC are determined by the ratio of reinforcement ratio and fiber volume fraction, rather than a single parameter, which also means that R-UHPC with different parameters may correspond to different methods to predict tensile load-bearing capacity. For UHPC with a fiber volume fraction low to 0.5%, incorporating steel rebars gives superior multi-crack cracking behavior and excellent capacity to restrict the maximum crack width. Increasing the fiber volume fraction from 0.5% to 1.0% at the same reinforcement ratio will yield little benefit other than an increase in tensile load-bearing capacity. Full article
(This article belongs to the Collection Concrete and Building Materials)
23 pages, 1365 KiB  
Review
An Overview of the Thermochemical Valorization of Sewage Sludge: Principles and Current Challenges
by Bruna Rijo, Catarina Nobre, Paulo Brito and Paulo Ferreira
Energies 2024, 17(10), 2417; https://doi.org/10.3390/en17102417 (registering DOI) - 17 May 2024
Abstract
With the increase in the world population and economic activity, the production of sewage sludge has grown, and its management has become an environmental problem. The most traditional method of managing sewage sludge is to dispose of it in landfills and on farmland. [...] Read more.
With the increase in the world population and economic activity, the production of sewage sludge has grown, and its management has become an environmental problem. The most traditional method of managing sewage sludge is to dispose of it in landfills and on farmland. One way to valorize sewage sludge is to use thermochemical conversion processes to produce added-value products such as biochar, biofuels, and renewable gases. However, due to the high moisture content, thermochemical conversion using processes such as pyrolysis and traditional gasification involves multiple pre-treatment processes such as material drying. Hydrothermal thermochemical processes usually require high pressures, which pose many challenges to their application on a large scale. In this work, the advantages and disadvantages of the different existing thermochemical processes for the recovery of sewage sludge were analyzed, as well as the resulting industrial and environmental challenges. A SWOT analysis was carried out to assess the different thermochemical processes in terms of technical feasibility, economic viability, and broader market considerations. Full article
(This article belongs to the Special Issue Sustainable Technologies for Decarbonising the Energy Sector)
34 pages, 1147 KiB  
Review
Neurotoxicity of Some Environmental Pollutants to Zebrafish
by Teodora Maria Buzenchi Proca, Carmen Solcan and Gheorghe Solcan
Life 2024, 14(5), 640; https://doi.org/10.3390/life14050640 (registering DOI) - 17 May 2024
Abstract
The aquatic environment encompasses a wide variety of pollutants, from plastics to drug residues, pesticides, food compounds, and other food by-products, and improper disposal of waste is the main cause of the accumulation of toxic substances in water. Monitoring, assessing, and attempting to [...] Read more.
The aquatic environment encompasses a wide variety of pollutants, from plastics to drug residues, pesticides, food compounds, and other food by-products, and improper disposal of waste is the main cause of the accumulation of toxic substances in water. Monitoring, assessing, and attempting to control the effects of contaminants in the aquatic environment are necessary and essential to protect the environment and thus human and animal health, and the study of aquatic ecotoxicology has become topical. In this respect, zebrafish are used as model organisms to study the bioaccumulation, toxicity, and influence of environmental pollutants due to their structural, functional, and material advantages. There are many similarities between the metabolism and physiological structures of zebrafish and humans, and the nervous system structure, blood–brain barrier function, and social behavior of zebrafish are characteristics that make them an ideal animal model for studying neurotoxicity. The aim of the study was to highlight the neurotoxicity of nanoplastics, microplastics, fipronil, deltamethrin, and rotenone and to highlight the main behavioral, histological, and oxidative status changes produced in zebrafish exposed to them. Full article
(This article belongs to the Special Issue Veterinary Pathology and Veterinary Anatomy)
17 pages, 897 KiB  
Article
Adaptive Grazing of Native Grasslands Provides Ecosystem Services and Reduces Economic Instability for Livestock Systems in the Flooding Pampa, Argentina
by Elizabeth J. Jacobo, Ulises J. Martínez Ortiz, Santiago M. Cotroneo and Adriana M. Rodríguez
Sustainability 2024, 16(10), 4229; https://doi.org/10.3390/su16104229 (registering DOI) - 17 May 2024
Abstract
There is a widespread concern about the negative impact of intensive livestock farming on climate change and biodiversity loss. We analyzed the trade-off between meat production and environmental variables related to global warming—energy consumption, use efficiency of energy, greenhouse gas (GHG) emissions, carbon [...] Read more.
There is a widespread concern about the negative impact of intensive livestock farming on climate change and biodiversity loss. We analyzed the trade-off between meat production and environmental variables related to global warming—energy consumption, use efficiency of energy, greenhouse gas (GHG) emissions, carbon footprint, and GHG balance—of two alternative intensification strategies of livestock farming in the Flooding Pampa: conventional intensification (CI) based on external inputs, and ecological intensification (EI) based on maintaining native grassland in good condition through adaptive multi-paddock grazing (AMPG). We also explored the relationship between meat production and the economic variables gross margin and its year-to-year variation. Energy consumption was positively correlated with meat production (ρ = 0.95, p= 0.0117), and EI farms consumed less fuel energy and showed higher energy use efficiency than CI farms (294 ± 152 vs. 2740 ± 442 MJ ha−1 y−1, 38.4 ± 28.8 vs. 1.23 ± 0.13 MJ kg LW−1 y−1, p < 0.05, respectively). GHG emissions and carbon footprint did not show significant differences between EI and CI strategies. As soil carbon sequestration was significantly higher in EI farms than in CI farms (1676 ± 304 vs. −433 ± 343 kg CO2eq ha−1 y−1, p <0.05), GHG balance resulted almost neutral and higher under the EI strategy (−693 ± 732 vs. −3520 ± 774 kg CO2eq ha−1 y−1, p < 0.05). CI strategy obtained higher meat production but a similar gross margin to the EI strategy and a more unstable economic return, as the coefficient of variation in the gross margin doubled that of the EI strategy (84 + 13.3 vs. 43 + 2.6, respectively, p < 0.05). Ecological intensification of cattle production in the Flooding Pampa demonstrates the potential for a positive relationship between individual cattle farmers’ profits and overall societal benefits, as reflected in improved environmental performance. Full article
(This article belongs to the Special Issue Plants, Biodiversity and Sustainable Ecosystem)
14 pages, 387 KiB  
Article
Molecular Markers in Melanoma Progression: A Study on the Expression of miRNA Gene Subtypes in Tumoral vs. Benign Nevi
by Mihaela Prodan, Sergiu Costescu, Ahmed Elagez, Sorina Maria Denisa Laitin, Vlad Bloanca, Zorin Crainiceanu, Edward Seclaman, Ana-Olivia Toma, Roxana Manuela Fericean, George Puenea and Gabriel Veniamin Cozma
Curr. Oncol. 2024, 31(5), 2881-2894; https://doi.org/10.3390/curroncol31050220 (registering DOI) - 17 May 2024
Abstract
This study investigates the differential expression of miRNA gene subtypes in tumoral versus benign nevi in individuals with melanoma, aiming to identify clinically significant correlations that could serve as reliable markers for assessing tumor stage and progression. Conducted between 2019 and 2022, this [...] Read more.
This study investigates the differential expression of miRNA gene subtypes in tumoral versus benign nevi in individuals with melanoma, aiming to identify clinically significant correlations that could serve as reliable markers for assessing tumor stage and progression. Conducted between 2019 and 2022, this descriptive, quantitative observational research analyzed 90 formalin-fixed paraffin-embedded (FFPE) samples from the Pius Brinzeu County Emergency Clinical Hospital, Timisoara, including 45 samples of advanced-stage melanoma and 45 samples of pigmented nevi. miRNA purification and analysis were performed using the miRNeasy Kit and the Human Cancer PathwayFinder miScript miRNA PCR Array, with statistical analysis (including logistic regression) to determine associations with cancer staging, such as high Breslow index risk, number of mitoses, and vascular invasion. After the analysis and comparison of 180 miRNA gene subtypes, we selected 10 of the most upregulated and 10 most downregulated genes. The results revealed that hsa-miR-133b, hsa-miR-335-5p, hsa-miR-200a-3p, and hsa-miR-885-5p were significantly upregulated in melanoma samples, with fold changes ranging from 1.09 to 1.12. Conversely, hsa-miR-451a and hsa-miR-29b-3p showed notable downregulation in melanoma, with fold changes of 0.90 and 0.92, respectively. Additionally, logistic regression analysis identified hsa-miR-29b-3p (OR = 2.51) and hsa-miR-200a-3p (OR = 2.10) as significantly associated with an increased risk of a high Breslow index, while hsa-miR-127-3p and hsa-miR-451a were associated with a reduced risk. Conclusively, this study underscores the significant alterations in miRNA expression in melanoma compared to benign nevi and highlights the potential of specific miRNAs as biomarkers for melanoma progression. The identification of miRNAs with significant associations to melanoma characteristics suggests their utility in developing non-invasive, cost-effective diagnostic tools and in guiding therapeutic decisions, potentially improving patient outcomes in melanoma management. Full article
(This article belongs to the Special Issue Epidemiology and Risk Factors of Skin Cancer)
31 pages, 2416 KiB  
Article
Investigating and Improving Pedestrian Safety in an Urban Environment of a Low- or Middle-Income Country: A Case Study of Yaoundé, Cameroon
by Steffel Ludivin Tezong Feudjio, Dimitri Tchaheu Tchaheu, Stephen Kome Fondzenyuy, Isaac Ndumbe Jackai II, Davide Shingo Usami and Luca Persia
Future Transp. 2024, 4(2), 548-578; https://doi.org/10.3390/futuretransp4020026 (registering DOI) - 17 May 2024
Abstract
In Yaoundé, Cameroon, where walking dominates transport modes, pedestrian safety remains an issue as pedestrians account for a fair share of road traffic casualties, partly due to the lack of walking policies and pedestrian facilities safety data, hindering targeted intervention. This study used [...] Read more.
In Yaoundé, Cameroon, where walking dominates transport modes, pedestrian safety remains an issue as pedestrians account for a fair share of road traffic casualties, partly due to the lack of walking policies and pedestrian facilities safety data, hindering targeted intervention. This study used a pedestrian safety index (PSI) and the Global Walkability Index (GWI) to investigate 12 road segments frequented by diverse pedestrian groups. Indexes were graded from E—lowest to A—highest and analyzed using description and rank correlation. Main safety issues included lack of adequate and accessible sidewalks, bollards, pedestrian crossings, signage, shade, and street lighting. Only one segment (R7) achieved grade C, while the remainder scored D or E, indicating poor pedestrian safety conditions and an unpleasant walking experience. The correlation coefficient (0.69) between the PSI and GWI at a 99% significance level validated the safety assessment, providing confidence in the results. A seven-year (2024–2030) safety strategy is proposed to improve all roads to grade B. This strategy contains several interventions, including engineering improvement, which have been proven effective. This study offers evidence for city officials to improve pedestrian safety and informs walking policies and the implementation of upcoming projects. Future research should quantify the recommendations’ benefits and validate indexes with crash or conflict data. Full article
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26 pages, 5983 KiB  
Article
Geoinformatics-Based Mapping of Environmental Sensitive Areas for Desertification over Satara and Sangli Districts of Maharashtra, India
by Chandra Shekhar Dwivedi, Dishant, Bikash Ranjan Parida, Arvind Chandra Pandey, Ravi Kumar and Navneet Kumar
GeoHazards 2024, 5(2), 415-440; https://doi.org/10.3390/geohazards5020022 (registering DOI) - 17 May 2024
Abstract
Desertification processes in arid, semi-arid, and dry sub-humid conditions have been enhanced in recent decades. The geospatial database and associated satellite data can be effectively employed for regional planning to address desertification and land degradation. In this study, the Mediterranean Desertification and Land [...] Read more.
Desertification processes in arid, semi-arid, and dry sub-humid conditions have been enhanced in recent decades. The geospatial database and associated satellite data can be effectively employed for regional planning to address desertification and land degradation. In this study, the Mediterranean Desertification and Land Use (MEDALUS) model has been used to map environmentally sensitive areas due to desertification in the Satara and Sangli districts of Maharashtra, India. This was achieved by combining Landsat-8 multispectral data, Census data, soil data, and climatic variables like temperature, rainfall, and evapotranspiration. The algorithm of MEDALUS is the geometric mean of four indicators, namely soil quality index (SQI), climate quality index (CQI), vegetation quality index (VQI), and socio-economic quality index (SEQI). The findings indicated that the majority of the study area comes under the potential category of desertification (60.32%) followed by fragile (27.87%) and critical (11.81%). Areas with a high propensity for desertification were found over the low to very low climatic quality and moderate to high soil quality including lower socio-economic quality. The lower socio-economic quality is mainly due to high to very high population density (>100 people/km2), low to moderate illiteracy rate (<16%), and low to moderate work participation rate (<50%) that incentivize unsustainable land use practices. The study provides a valuable tool for understanding and managing natural resources. It offers a detailed analysis of the environmental sensitivity of the study area, taking into account various factors like land use, vegetation cover, slope, and soil erosion potential. The developed comprehensive map of the area helps in identifying the most sensitive regions and developing appropriate conservation strategies. The information obtained from the study can be utilized to develop and implement successful measures to prevent or alleviate desertification, which is crucial for sustaining the health of ecosystems and the welfare of local residents. Full article
13 pages, 472 KiB  
Article
Academic Performance of Excellence: The Impact of Self-Regulated Learning and Academic Time Management Planning
by Abílio Afonso Lourenço and Maria Olímpia Paiva
Knowledge 2024, 4(2), 289-301; https://doi.org/10.3390/knowledge4020016 (registering DOI) - 17 May 2024
Abstract
The Program for International Student Assessment highlights the persistent lack of commitment and motivation among students worldwide in their school activities, which are resulting in decreased proficiency levels in reading, mathematics, and science. The magnitude of this phenomenon, with its clear social implications, [...] Read more.
The Program for International Student Assessment highlights the persistent lack of commitment and motivation among students worldwide in their school activities, which are resulting in decreased proficiency levels in reading, mathematics, and science. The magnitude of this phenomenon, with its clear social implications, suggests that we are facing a concerning quest for immediate answers and results. This research focuses on the impact of the relationships between self-regulated learning processes and the planning of time management that is dedicated to school activities on student performance, specifically in the subjects of the Mother Tongue and Mathematics. The instruments used for analysis included the Inventory of Self-Regulated Learning Processes, the Inventory of Time Management Planning, a personal data sheet, and a school data sheet. The sample in this study consisted of 688 students from primary schools in northern Portugal. The results reveal that self-regulated learning has a positive influence on how students plan time management, both in the short and long term. Additionally, a positive and statistically significant relationship is observed between short-term and long-term time management planning and students’ academic performance. This study provides an in-depth perspective on the dynamics between these elements, shedding light on the crucial nuances that shape students’ academic journeys. Full article
12 pages, 37783 KiB  
Article
Microscopic Image Dataset with Segmentation and Detection Labels for Microplastic Analysis in Sewage: Enhancing Research and Environmental Monitoring
by Gwanghee Lee, Jaeheon Jung, Sangjun Moon, Jihyun Jung and Kyoungson Jhang
Microplastics 2024, 3(2), 264-275; https://doi.org/10.3390/microplastics3020016 (registering DOI) - 17 May 2024
Abstract
We introduce a novel microscopic image dataset augmented with segmentation and detection labels specifically designed for microplastic analysis in sewage environments. Recognizing the increasing concern over microplastics—particles of synthetic polymers smaller than 5 mm—and their detrimental effects on marine ecosystems and human health, [...] Read more.
We introduce a novel microscopic image dataset augmented with segmentation and detection labels specifically designed for microplastic analysis in sewage environments. Recognizing the increasing concern over microplastics—particles of synthetic polymers smaller than 5 mm—and their detrimental effects on marine ecosystems and human health, our research focuses on enhancing detection and analytical methodologies through advanced computer vision and deep learning techniques. The dataset comprises high-resolution microscopic images of microplastics collected from sewage, meticulously labeled for both segmentation and detection tasks, aiming to facilitate accurate and efficient identification and quantification of microplastic pollution. In addition to dataset development, we present example deep learning models optimized for segmentation and detection of microplastics within complex sewage samples. The models demonstrate significant potential in automating the analysis of microplastic contamination, offering a scalable solution to environmental monitoring challenges. Furthermore, we ensure the accessibility and reproducibility 12 of our research by making the dataset and model codes publicly available, accompanied by detailed 13 documentation on GitHub and LabelBox. Full article
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25 pages, 2085 KiB  
Article
Size and Shape Selective Classification of Nanoparticles
by Cornelia Damm, Danny Long, Johannes Walter and Wolfgang Peukert
Powders 2024, 3(2), 255-279; https://doi.org/10.3390/powders3020016 (registering DOI) - 17 May 2024
Abstract
As nanoparticle syntheses on a large scale usually yield products with broad size and shape distributions, the properties of nanoparticle-based products need to be tuned after synthesis by narrowing the size and shape distributions or via the removal of undesired fractions. The development [...] Read more.
As nanoparticle syntheses on a large scale usually yield products with broad size and shape distributions, the properties of nanoparticle-based products need to be tuned after synthesis by narrowing the size and shape distributions or via the removal of undesired fractions. The development of property-selective classification processes requires a universal framework for the quantitative evaluation of multi-dimensional particle fractionation processes. This framework must be applicable to any property and any particle classification process. We extended the well-known one-dimensional methodology commonly used for describing particle size distributions and fractionation processes to the multi-dimensional case to account for the higher complexity of the property distribution and separation functions. In particular, multi-dimensional lognormal distributions are introduced and applied to diameter and length distributions of gold nanorods. The fractionation of nanorods via centrifugation and by orthogonal centrifugal and electric forces is modeled. Moreover, we demonstrate that analytical ultracentrifugation with a multi-wavelength detector (MWL-AUC) is a fast and very accurate method for the measurement of two-dimensional particle size distributions in suspension. The MWL-AUC method is widely applicable to any class of nanoparticles with size-, shape- or composition-dependent optical properties. In addition, we obtained distributions of the lateral diameter and the number of layers of molybdenum disulfide nanosheets via stepwise centrifugation and spectroscopic evaluation of the size fractions. Full article
19 pages, 3812 KiB  
Article
Evaluation of Tactile and Thermophysiological Comfort in Reusable Surgical Gowns Compared to Disposable Gowns
by Magdalena Georgievska, Abreha Bayrau Nigusse, Benny Malengier, Hasan Riaz Tahir, Charlotte Harding, Sufiyan Derbew Tiku and Lieva Van Langenhove
Textiles 2024, 4(2), 237-255; https://doi.org/10.3390/textiles4020014 (registering DOI) - 17 May 2024
Abstract
Though the transition from disposable to reusable surgical gowns holds substantial promise, successful implementation faces challenges. This study investigated tactile and thermophysiological comfort in surgical reusable gowns, comparing them with their disposable counterparts. Parameters such as surface roughness, compression, heat flux, and material [...] Read more.
Though the transition from disposable to reusable surgical gowns holds substantial promise, successful implementation faces challenges. This study investigated tactile and thermophysiological comfort in surgical reusable gowns, comparing them with their disposable counterparts. Parameters such as surface roughness, compression, heat flux, and material rigidity were tested using a Fabric Touch Tester. Additionally, the water vapour permeability and static charge of the gowns were assessed. Thermophysiological comfort of the gowns was evaluated by measuring the temperature and relative humidity (RH) on test subjects during wear trials where they were engaged in an activity that mimics a surgeon’s performance. Skin temperature was monitored using iButton sensors and a thermal camera, and the impact on heart rate during the task was analysed. Following each test, participants provided subjective feedback through a questionnaire. The results indicated that reusable gowns boasted a smoother texture, translating to reduced friction on the skin and better heat transfer compared to the disposable fabrics, as indicated using FTT. They also exhibited higher water vapour permeability compared to their disposable counterparts. The wear trials revealed minimal differences in comfort between disposable and reusable gowns. While performing the activity, an increase in body temperature led to decreased RH, yet this rise did not adversely affect subject comfort, as validated using heart rate and questionnaire survey data. From a comfort point of view, switching from disposable to reusable gowns would not have drawbacks, meaning hospitals should be able to switch provided logistics and costs can be managed. Full article
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16 pages, 1070 KiB  
Article
Density and Composition of Cohabiting Bacteria in Chlorella vulgaris CCAP 211/21A is Influenced by Changes in Nutrient Supply
by Wasayf J Almalki, Alison O. Nwokeoji and Seetharaman Vaidyanathan
SynBio 2024, 2(2), 190-205; https://doi.org/10.3390/synbio2020011 (registering DOI) - 17 May 2024
Abstract
Microalgae have considerable potential as a renewable feedstock for biochemical and bioethanol production that can be employed in processes associated with carbon capture. Large-scale microalgae cultivations are often non-axenic and are often cohabited by bacteria. A better understanding of the influence of cohabiting [...] Read more.
Microalgae have considerable potential as a renewable feedstock for biochemical and bioethanol production that can be employed in processes associated with carbon capture. Large-scale microalgae cultivations are often non-axenic and are often cohabited by bacteria. A better understanding of the influence of cohabiting bacteria on microalgae productivity is required to develop sustainable synthetic co-culture processes at scale. Nutrient limitation is a frequently employed strategy in algal cultivations to accumulate energy reserves, such as lipids and carbohydrates. Here, a non-axenic culture of an estuarine green microalga, Chlorella vulgaris CCAP 211/21A, was studied under nutrient replete and deplete conditions to assess how changes in nutrient supply influenced the cohabiting bacterial population and its association with intracellular carbohydrate accumulations in the alga. Nutrient limitation resulted in a maximum carbohydrate yield of 47%, which was 74% higher than that in nutrient replete conditions. However, the latter condition elicited a 2-fold higher carbohydrate productivity. Three cohabiting bacterial isolates were cultivable from the three culture conditions tested. These isolates were identified using the 16S rRNA gene sequence to belong to Halomonas sp. and Muricauda sp. The composition of the bacterial population varied significantly between the growth conditions and time points. In all cases and at all time points, the dominant species was Halomonas isolates. Nutrient depletion resulted in an apparent loss of Muricauda sp. This finding demonstrates that nutrient supply can be used to control cohabiting bacterial populations in algal cultures, which will enable the development of synthetic co-culture strategies for improving algae productivity. Full article
16 pages, 1997 KiB  
Article
Feasibility of Using Green Laser for Underwater Infrastructure Monitoring: Case Studies in South Florida
by Rahul Dev Raju, Sudhagar Nagarajan, Madasamy Arockiasamy and Stephen Castillo
Geomatics 2024, 4(2), 173-188; https://doi.org/10.3390/geomatics4020010 (registering DOI) - 17 May 2024
Abstract
Scour around bridges present a severe threat to the stability of railroad and highway bridges. Scour needs to be monitored to prevent the bridges from becoming damaged. This research studies the feasibility of using green laser for monitoring the scour around candidate railroad [...] Read more.
Scour around bridges present a severe threat to the stability of railroad and highway bridges. Scour needs to be monitored to prevent the bridges from becoming damaged. This research studies the feasibility of using green laser for monitoring the scour around candidate railroad and highway bridges. The laboratory experiments that provided the basis for using green laser for underwater mapping are also discussed. The results of the laboratory and field experiments demonstrate the feasibility of using green laser for underwater infrastructure monitoring with limitations on the turbidity of water that affects the penetrability of the laser. This method can be used for scour monitoring around offshore structures in shallow water as well as corrosion monitoring of bridges. Full article

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