The 2023 MDPI Annual Report has
been released!
 
16 pages, 6450 KiB  
Article
Enhancement of Filtration Performance Characteristics of Glass Fiber-Based Filter Media, Part 1: Mechanical Modification with Electrospun Nanofibers
by Laura Weiter, Stephan Leyer and John K. Duchowski
Materials 2024, 17(10), 2209; https://doi.org/10.3390/ma17102209 (registering DOI) - 08 May 2024
Abstract
Various modifications of standard glass fiber filtration media using electrospun PA66 nanofibers are described. PA66 were selected because they were readily available from commercial sources. Other polymers, such as PP, PET and PBT, could also be used. The first set of samples was [...] Read more.
Various modifications of standard glass fiber filtration media using electrospun PA66 nanofibers are described. PA66 were selected because they were readily available from commercial sources. Other polymers, such as PP, PET and PBT, could also be used. The first set of samples was prepared by mixing the nanofibers at two, three and five weight percent with glass fibers, and the second by laying the same proportion of the nanofibers directly onto the downstream side of the substrate. The aim of these modifications was to improve the three most basic functionalities of filter media, the separation efficiency, the differential pressure (ΔP) and the dirt holding capacity (DHC). The modified media samples were evaluated with the standard textile characterization techniques and filtration performance evaluation procedures. The results showed differences in the several tens of percentage points achieved with the two modification methods. Moreover, additional differences in performance were observed depending on the percentage of nanofibers admixed to the substrate. These differences were most apparent in the filtration efficiency and the DHC, both by several percentage points, with no apparent effect on the ∆P. The results strongly suggest that the preparation of new filter media by incorporating nanofibers directly into the matrix can result in significant improvements in filtration performance characteristics. Full article
(This article belongs to the Special Issue Properties and Applications of Advanced Textile Materials)
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22 pages, 2481 KiB  
Article
Symmetric Collaborative Fault-Tolerant Control of Multi-Intelligence under Long-Range Transmission in Air–Ground Integrated Wireless High-Mobility Self-Organizing Networks
by Zhifang Wang, Mingzhe Shao, Wenke Xu, Xuewei Huang, Yang Bai, Quanzhen Huang and Jianguo Yu
Symmetry 2024, 16(5), 582; https://doi.org/10.3390/sym16050582 (registering DOI) - 08 May 2024
Abstract
With the continuous development and progress of wireless self-organizing network communication technology, how to carry out long-distance cooperative control of multiple intelligences under the framework of an air–ground integrated wireless high-mobility self-organizing network has become a hot and difficult topic that needs to [...] Read more.
With the continuous development and progress of wireless self-organizing network communication technology, how to carry out long-distance cooperative control of multiple intelligences under the framework of an air–ground integrated wireless high-mobility self-organizing network has become a hot and difficult topic that needs to be solved urgently. This paper takes the air–ground integrated wireless high-mobility self-organizing network system as the basic framework and focuses on solving the long-distance cooperative fault-tolerant control of multi-intelligent bodies and the topological stability of a wireless mobile self-organizing network. To solve the above problems, a direct neural network with a robust adaptive fault-tolerant controller is designed in this paper. By constructing a symmetric population neural network model and combining it with the Lyapunov stabilization criterion, the system feedback matrix K has the ability of autonomous adaptive learning, and symmetrically distorts, rotates, or scales the training data to instantly adjust the system’s fault-tolerant corrections and adaptive adjusting factors to resist the unknown disturbances and faults, to achieve the goals of multi-intelligent body stable control and the stable operation of a wireless high-mobility self-organizing network topology. Simulation results show that with the feedback adjustment of the multi-system under the designed controller, the multi-system as a whole has good fault-tolerant performance and autonomous learning approximation performance, and the tracking error asymptotically converges to zero. The experimental results show that the multi-flight subsystems fly stably, the air–ground integrated wireless high-mobility self-organizing network topology has good stability performance, and the maximum relative improvement of the topology stability performance is 50%. Full article
(This article belongs to the Special Issue Symmetry/Asymmetry in Wireless Communication and Sensor Networks II)
17 pages, 598 KiB  
Article
On Spontaneous Dispersion as a Cause of Microstratification of Metal Melts
by Olga A. Chikova, Vladimir S. Tsepelev and Kseniya Yu. Shmakova
Materials 2024, 17(10), 2215; https://doi.org/10.3390/ma17102215 (registering DOI) - 08 May 2024
Abstract
The phenomenon of spontaneous dispersion is considered as the cause of the microstratification of metal melts. In a microstratification melt, a violation of long-range order in the arrangement of atoms (LRO) is observed, which corresponds to a dispersed particle size of more than [...] Read more.
The phenomenon of spontaneous dispersion is considered as the cause of the microstratification of metal melts. In a microstratification melt, a violation of long-range order in the arrangement of atoms (LRO) is observed, which corresponds to a dispersed particle size of more than 2 nm. Microseparation occurs due to spontaneous dispersion upon contact of liquid and solid metal or the mixing of two liquid metals. The possibility of spontaneous dispersion was assessed using three different criteria: Volmer’s criterion, Rehbinder’s criterion and the diffusion rate criterion. The diffusion rate criterion was obtained on the basis of the theory of rate processes, which describes how diffusing atoms overcome the interphase boundary. It has been established that Al–Sn melts contain colloidal-scale particles (4 nm), and Al–Si and Al–Ge melts contain atomic-scale particles (0.1 nm). For a system with a continuous series of Cu–Ni solid solutions in dispersion (Cu10Ni90—Cu20Ni80), the particle size is 2 nm. The particle size of the ternary eutectic GaInSn in the dispersion (Ga50In50—Ga50Sn50) is 5.6 nm, and the size of immiscible Cu–Fe melts in the dispersion (Cu80Fe20—Cu60Fe40) is 4.8 nm. Long-range order violations (LRO) and the presence of microlayering with colloidal particles larger than 20 nm were observed in the GaInSn ternary eutectic, in the Al–Sn simple eutectic with the preferential interaction of similar atoms, and in Cu–Fe melts with a monotectic phase diagram. Full article
(This article belongs to the Special Issue Liquid Metals: From Fundamentals to Applications)
20 pages, 481 KiB  
Article
Research on the Activation Path of Employees’ Openness to Digital Transformation: A New Impetus to Realize Enterprises’ Digital Transformation for Sustainable Development
by Yanhua Zhou and Zilong Li
Sustainability 2024, 16(10), 3945; https://doi.org/10.3390/su16103945 (registering DOI) - 08 May 2024
Abstract
Digital transformation is an important strategic decision for the sustainable development of enterprises, which helps enterprises achieve sustainable performance, sustainable management, and even sustainable business models. While there have been a number of useful studies discussing the impetus of digital transformation, most of [...] Read more.
Digital transformation is an important strategic decision for the sustainable development of enterprises, which helps enterprises achieve sustainable performance, sustainable management, and even sustainable business models. While there have been a number of useful studies discussing the impetus of digital transformation, most of them have neglected the role from employees, especially their attitudes and perceptions towards transformation. Focusing on employees’ openness to digital transformation, we selected six antecedents to construct a configuration model, using fsQCA and NCA methods to explore the complex causal relationship between each antecedent and openness to digital transformation. This aims to derive the activation paths for employees’ openness to digital transformation, so as to help the enterprises’ digital transformation and further achieve sustainable development. Through the data analysis of 462 employees of Chinese enterprises, the following conclusions are drawn: firstly, single antecedents are not necessary conditions for high/non-high digital transformation openness activation; secondly, there are three configurations associated with the high openness activation of digital transformation: a comprehensive collaboration type under internal environment dominance (S1a + S1b), the consideration of both an internal and external environment type under mindfulness characteristics’ dominance (S2), and a mindful substitution type under internal environment dominance (S3); and finally, there are four configurations associated with non-high digital transformation openness activation and an asymmetric relationship exists with the high digital transformation openness activation path. Full article
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21 pages, 6337 KiB  
Article
An Improved Pedotransfer Function for Soil Hydrological Properties in New Zealand
by Stephen McNeill, Linda Lilburne, Shirley Vickers, Trevor Webb and Samuel Carrick
Appl. Sci. 2024, 14(10), 3997; https://doi.org/10.3390/app14103997 (registering DOI) - 08 May 2024
Abstract
This paper describes a new pedotransfer function (PTF) for the soil water content of New Zealand soils at seven specific tensions (0, −5, −10, −20, −40, −100, −1500 kPa) using explanatory variables derived from the S-map soil mapping system. The model produces unbiased [...] Read more.
This paper describes a new pedotransfer function (PTF) for the soil water content of New Zealand soils at seven specific tensions (0, −5, −10, −20, −40, −100, −1500 kPa) using explanatory variables derived from the S-map soil mapping system. The model produces unbiased and physically plausible estimates of the response at each tension, as well as unbiased and physically plausible estimates of the response differences that define derived properties (e.g., macroporosity and total available water content). The PTF is a development of an earlier model using approximately double the number of sites compared with the earlier study, a change in fitting methodology to a semi-parametric GAM Beta response, and the inclusion of sample depth. The results show that the new model has resulted in significant improvements for the soil water content estimates and derived quantities using standard goodness-of-fit measures, based on validation data. A comparison with an international PTF using explanatory variables compatible with variables available from S-map (EUPTF2) suggests that the model is better for prediction of soil water content using the limited information available from the S-map system. Full article
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14 pages, 1543 KiB  
Article
Ultrastructural Changes of Neuroendocrine Pheochromocytoma Cell Line PC-12 Exposed In Vitro to Rotenone
by Manuel Belli, Mario Cristina, Valeria Calabrese, Marta Russo, Marisa Granato, Matteo Antonio Russo and Luigi Sansone
Brain Sci. 2024, 14(5), 476; https://doi.org/10.3390/brainsci14050476 (registering DOI) - 08 May 2024
Abstract
Rotenone is a pesticide used in research for its ability to induce changes similar, in vivo and in vitro, to those observed in Parkinson’s disease (PD). This includes a selective death of dopaminergic neurons in the substantia nigra. Nonetheless, the precise mechanism through [...] Read more.
Rotenone is a pesticide used in research for its ability to induce changes similar, in vivo and in vitro, to those observed in Parkinson’s disease (PD). This includes a selective death of dopaminergic neurons in the substantia nigra. Nonetheless, the precise mechanism through which rotenone modifies structure and function of neurons remains unclear. The PC12 cells closely resemble dopamine terminal neurons. This makes it a preferred model for studying the morphology of central dopamine neurons and predicting neurotoxicity. In this paper, we investigated the effects of 0.5 µM rotenone for 24–48 h on PC12 cell viability and ultrastructure (TEM), trying to identify primary and more evident alterations that can be related to neuronal damages similar to that seen in animal PD models. Cell viability decreased after 24 h rotenone treatment, with a further decrease after 48 h. Ultrastructural changes included vacuolar degeneration, mitochondrial mild swelling, decrease in the number of neuropeptide granules, and the loss of cell-to-cell adhesion. These findings are in agreement with previous research suggesting that rotenone, by inhibiting energy production and increasing ROS generation, is responsible for significant alterations of the ultrastructure and cell death of PC12 cells. Our data confirm the link between rotenone exposure, neuronal damage, and changes in dopamine metabolism, suggesting its role in the pathogenesis of PD. Full article
(This article belongs to the Special Issue Advanced Studies of the Neuron Model of Neurodegenerative Diseases)
17 pages, 958 KiB  
Article
Study on SEAI Model of COVID-19 Based on Asymptomatic Infection
by Lidong Huang, Yue Xia and Wenjie Qin
Axioms 2024, 13(5), 309; https://doi.org/10.3390/axioms13050309 (registering DOI) - 08 May 2024
Abstract
In this paper, an SEAI epidemic model with asymptomatic infection is studied under the background of mass transmission of COVID-19. First, we use the next-generation matrix method to obtain the basic reproductive number R0 and calculate the equilibrium point. Secondly, when [...] Read more.
In this paper, an SEAI epidemic model with asymptomatic infection is studied under the background of mass transmission of COVID-19. First, we use the next-generation matrix method to obtain the basic reproductive number R0 and calculate the equilibrium point. Secondly, when R0<1, the local asymptotic stability of the disease-free equilibrium is proved by Hurwitz criterion, and the global asymptotic stability of the disease-free equilibrium is proved by constructing the Lyapunov function. When R0>1, the system has a unique endemic equilibrium point and is locally asymptotically stable, and it is also proved that the system is uniformly persistent. Then, the application of optimal control theory is carried out, and the expression of the optimal control solution is obtained. Finally, in order to verify the correctness of the theory, the stability of the equilibrium point is numerically simulated and the sensitivity of the parameters of R0 is analyzed. We also simulated the comparison of the number of asymptomatic infected people and symptomatic infected people before and after adopting the optimal control strategy. This shows that the infection of asymptomatic people cannot be underestimated in the spread of COVID-19 virus, and an isolation strategy should be adopted to control the spread speed of the disease. Full article
22 pages, 1823 KiB  
Article
Computation of the Mann–Whitney Effect under Parametric Survival Copula Models
by Kosuke Nakazono, Yu-Cheng Lin, Gen-Yih Liao, Ryuji Uozumi and Takeshi Emura
Mathematics 2024, 12(10), 1453; https://doi.org/10.3390/math12101453 (registering DOI) - 08 May 2024
Abstract
The Mann–Whitney effect is a measure for comparing survival distributions between two groups. The Mann–Whitney effect is interpreted as the probability that a randomly selected subject in a group survives longer than a randomly selected subject in the other group. Under the independence [...] Read more.
The Mann–Whitney effect is a measure for comparing survival distributions between two groups. The Mann–Whitney effect is interpreted as the probability that a randomly selected subject in a group survives longer than a randomly selected subject in the other group. Under the independence assumption of two groups, the Mann–Whitney effect can be expressed as the traditional integral formula of survival functions. However, when the survival times in two groups are not independent of each other, the traditional formula of the Mann–Whitney effect has to be modified. In this article, we propose a copula-based approach to compute the Mann–Whitney effect with parametric survival models under dependence of two groups, which may arise in the potential outcome framework. In addition, we develop a Shiny web app that can implement the proposed method via simple commands . Through a simulation study, we show the correctness of the proposed calculator. We apply the proposed methods to two real datasets. Full article
(This article belongs to the Special Issue Statistical Analysis and Data Science for Complex Data)
19 pages, 4929 KiB  
Article
Effect of In Situ Heating on the Growth and Electrochromic Properties of Tungsten Trioxide Thin Films
by Jinfeng Xu, Xirui Li, Yong Zhang, Xueru Zhang, Jiaqin Liu and Yucheng Wu
Materials 2024, 17(10), 2214; https://doi.org/10.3390/ma17102214 (registering DOI) - 08 May 2024
Abstract
Electrochromism has emerged as a pivotal technology in the pursuit of energy efficiency and environmental sustainability, spurring significant research efforts aimed at the creation of advanced electrochromic devices. Most electrochromic materials are used for smart window applications. However, current electrochromic materials have been [...] Read more.
Electrochromism has emerged as a pivotal technology in the pursuit of energy efficiency and environmental sustainability, spurring significant research efforts aimed at the creation of advanced electrochromic devices. Most electrochromic materials are used for smart window applications. However, current electrochromic materials have been applied to new energy vehicles, cell phone back covers, AR glasses, and so on. More application scenarios put forward more requirements for the color of the colored states. Choosing the right color change in the application will be the trend in the future. In this work, tungsten trioxide (WO3) thin films were prepared by adjusting the in situ heating temperature. WO3 with a crystalline structure showed excellent cyclic stability (5000 cycles), electrochromic performance (ΔT = 77.7% at 633 nm, CE = 37.1 cm2/C), relatively fast bleaching/coloring speed (20.0 s/19.4 s), and the darkest coloring effect (L* = 29.32, a* = 7.41, b* = −22.12 for the colored state). These findings offer valuable insights into the manipulation of smart materials and devices, contributing to the advancement of electrochromic technology. Full article
(This article belongs to the Special Issue Electrochromic Materials Research and Devices)
17 pages, 417 KiB  
Article
Microbiological Assessment of Dairy Products Produced by Small-Scale Dairy Producers in Serbia
by Biljana Aleksic, Bozidar Udovicki, Jovana Kovacevic, Zorana Miloradovic, Ilija Djekic, Jelena Miocinovic, Nikola Tomic and Nada Smigic
Foods 2024, 13(10), 1456; https://doi.org/10.3390/foods13101456 (registering DOI) - 08 May 2024
Abstract
The microbiological quality of dairy products from small-scale producers in Serbia was analysed. A total of 302 dairy products [raw (n = 111) and pasteurized milk cheeses (n = 79) and kajmak (n = 112)], were collected and tested for [...] Read more.
The microbiological quality of dairy products from small-scale producers in Serbia was analysed. A total of 302 dairy products [raw (n = 111) and pasteurized milk cheeses (n = 79) and kajmak (n = 112)], were collected and tested for the presence of pathogens, Listeria monocytogenes and Salmonella spp., and enumerated for Coagulase-positive staphylococci (CPS), Escherichia coli, and yeasts and moulds. None of the samples tested positive for Salmonella spp., while L. monocytogenes was recovered from one raw milk cheese and five kajmak samples. Raw milk cheese and kajmak also had higher levels of indicator microorganisms, namely E. coli and yeast and moulds. Molecular serotyping grouped L. monocytogenes isolates into serogroups 1 (1/2a and 3a) and 3 (1/2b, 3b, and 7). When exposed to eight antibiotics, L. monocytogenes isolates were mostly sensitive, with the exception of oxacillin and reduced susceptibility to clindamycin, penicillin G, and trimethoprim/sulfamethoxazole, emphasizing the importance of continuous surveillance for antimicrobial resistance. Samples that tested positive for Listeria spp. also had higher loads of indicator microorganisms, namely E. coli and yeast and moulds, suggesting lapses in hygiene practices during production. Collectively, these data emphasize the need for improved food safety and hygiene practices among small-scale dairy producers. This is crucial to reduce the microbial contamination and improve both the quality and safety of dairy products in the Serbian market. Full article
(This article belongs to the Special Issue Dairy Product: Microbiology, Sensory and Physico-Chemical Analysis)
14 pages, 1160 KiB  
Article
Effects of Oleanolic Acid Derived from Wine Pomace on Periodontopathic Bacterial Growth in Healthy Individuals: A Randomized Placebo-Controlled Study
by Kyoko Shimazu, Kouta Ookoshi, Satoshi Fukumitsu, Hiroyuki Kagami, Chieko Mitsuhata, Ryota Nomura and Kazuhiko Aida
Dent. J. 2024, 12(5), 133; https://doi.org/10.3390/dj12050133 (registering DOI) - 08 May 2024
Abstract
Periodontal disease is caused by oral pathogenic bacteria and is associated with systemic disease and frailty. Therefore, its prevention is crucial in extending healthy life expectancy. This study aimed to evaluate the effect of orally administered oleanolic acid, extracted from wine pomace, on [...] Read more.
Periodontal disease is caused by oral pathogenic bacteria and is associated with systemic disease and frailty. Therefore, its prevention is crucial in extending healthy life expectancy. This study aimed to evaluate the effect of orally administered oleanolic acid, extracted from wine pomace, on periodontopathic bacterial growth in healthy individuals. In this randomized, placebo-controlled, double-blind, parallel-group comparison study, 84 healthy adults were assigned to a placebo (n = 29), low-dose (n = 29, 9 mg oleanolic acid), or high-dose (n = 26, 27 mg oleanolic acid) groups. The number of oral bacteria in their saliva, collected before and 5 h after administration, was determined using the polymerase chain reaction-invader technique. The proportion of periodontopathic bacteria among the total oral bacteria in the saliva was calculated. Oleanolic acid significantly decreased the proportion of Porphyromonas gingivalis among the total oral bacteria in a dose-dependent manner (p = 0.005 (low-dose) and p = 0.003 (high-dose) vs. placebo, Williams’ test). Moreover, high-dose oleanolic acid decreased the proportion of Tannerella forsythia (p = 0.064 vs. placebo, Williams’ test). Periodontopathic bacteria are closely associated with the development and progression of periodontal disease; thus, the continuous daily intake of oleanolic acid derived from pomace may be helpful in maintaining a healthy oral microbiome by controlling the proportion of periodontopathic bacteria. Full article
(This article belongs to the Special Issue Oral Microbiology and Related Research)
51 pages, 3303 KiB  
Review
Skeletal Muscle Injury in Chronic Kidney Disease—From Histologic Changes to Molecular Mechanisms and to Novel Therapies
by Kylie Heitman, Matthew S. Alexander and Christian Faul
Int. J. Mol. Sci. 2024, 25(10), 5117; https://doi.org/10.3390/ijms25105117 (registering DOI) - 08 May 2024
Abstract
Chronic kidney disease (CKD) is associated with significant reductions in lean body mass and in the mass of various tissues, including skeletal muscle, which causes fatigue and contributes to high mortality rates. In CKD, the cellular protein turnover is imbalanced, with protein degradation [...] Read more.
Chronic kidney disease (CKD) is associated with significant reductions in lean body mass and in the mass of various tissues, including skeletal muscle, which causes fatigue and contributes to high mortality rates. In CKD, the cellular protein turnover is imbalanced, with protein degradation outweighing protein synthesis, leading to a loss of protein and cell mass, which impairs tissue function. As CKD itself, skeletal muscle wasting, or sarcopenia, can have various origins and causes, and both CKD and sarcopenia share common risk factors, such as diabetes, obesity, and age. While these pathologies together with reduced physical performance and malnutrition contribute to muscle loss, they cannot explain all features of CKD-associated sarcopenia. Metabolic acidosis, systemic inflammation, insulin resistance and the accumulation of uremic toxins have been identified as additional factors that occur in CKD and that can contribute to sarcopenia. Here, we discuss the elevation of systemic phosphate levels, also called hyperphosphatemia, and the imbalance in the endocrine regulators of phosphate metabolism as another CKD-associated pathology that can directly and indirectly harm skeletal muscle tissue. To identify causes, affected cell types, and the mechanisms of sarcopenia and thereby novel targets for therapeutic interventions, it is important to first characterize the precise pathologic changes on molecular, cellular, and histologic levels, and to do so in CKD patients as well as in animal models of CKD, which we describe here in detail. We also discuss the currently known pathomechanisms and therapeutic approaches of CKD-associated sarcopenia, as well as the effects of hyperphosphatemia and the novel drug targets it could provide to protect skeletal muscle in CKD. Full article
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22 pages, 959 KiB  
Article
Dynamic Encircling Cooperative Guidance for Intercepting Superior Target with Overload, Impact Angle and Simultaneous Time Constraints
by Dengfeng Yang and Xiaodong Yan
Aerospace 2024, 11(5), 375; https://doi.org/10.3390/aerospace11050375 (registering DOI) - 08 May 2024
Abstract
This paper proposes a dynamic encircling cooperative guidance (DECG) law to enable multiple interceptors to cooperatively intercept a superior target, considering low velocity, limited overload, impact angle and simultaneous arrival constraints. First, the feasible escaping area of the target is analyzed and a [...] Read more.
This paper proposes a dynamic encircling cooperative guidance (DECG) law to enable multiple interceptors to cooperatively intercept a superior target, considering low velocity, limited overload, impact angle and simultaneous arrival constraints. First, the feasible escaping area of the target is analyzed and a dynamic encircling strategy for the target is established. This strategy efficiently provides virtual escaping points, allowing interceptors to dynamically encircle the target without excessive energy consumption, ultimately leading to a successful interception. Second, to enhance the physical feasibility of the kinematic equations governing the interaction between interceptors and target at the virtual escaping points, the independent variable is substituted and the kinematic equations are remodeled. Convex optimization is employed to address the multi-constraint optimal guidance problem for each interceptor, thereby facilitating simultaneous interception. Compared with the existing guidance laws, DECG has a more practical and feasible cooperative strategy, is able to handle more constraints including the interceptor’s own constraints and cooperative constraints, and does not rely on the precise calculation of explicit remaining flight time in the guidance law implementation. Lastly, the effectiveness, superiority and robustness of the DECG law are evaluated through a series of numerical simulations, and its performance is compared with that of the cooperative proportional navigation guidance law (CPNG). Full article
22 pages, 5086 KiB  
Article
Box–Behnken Design-Based Optimization of Phytochemical Extraction from Diplazium esculentum (Retz.) Sw. Associated with Its Antioxidant and Anti-Alzheimer’s Properties
by Sirawit Kongsung, Woorawee Inthachat, Boonrat Chantong, Uthaiwan Suttisansanee, Nattira On-Nom, Chaowanee Chupeerach, Sirinapa Thangsiri, Pornsiri Pitchakarn and Piya Temviriyanukul
Molecules 2024, 29(10), 2204; https://doi.org/10.3390/molecules29102204 (registering DOI) - 08 May 2024
Abstract
A previous study reported that the ethanolic extract of the edible fern, Diplazium esculentum (Retz.) Sw. (DE), obtained from a non-optimized extraction condition exhibited anti-Alzheimer’s disease (AD) properties through the inhibition of a rate-limiting enzyme in amyloid peptide formation, β-secretase-1 (BACE-1). Nevertheless, a [...] Read more.
A previous study reported that the ethanolic extract of the edible fern, Diplazium esculentum (Retz.) Sw. (DE), obtained from a non-optimized extraction condition exhibited anti-Alzheimer’s disease (AD) properties through the inhibition of a rate-limiting enzyme in amyloid peptide formation, β-secretase-1 (BACE-1). Nevertheless, a non-optimized or suboptimal extraction may lead to several issues, such as a reduction in extraction efficiency and increased time and plant materials. In this study, extraction of the DE was optimized to obtain appropriate BACE-1 inhibition using a Box–Behnken design (BBD) and response surface methodology (RSM). Data revealed that the optimal extraction condition was 70% (v/v) aqueous ethanol, 50 min extraction time, 30 °C extraction temperature, and 1:30 g/mL solid/liquid ratio, giving BACE-1 inhibition at 56.33%. In addition, the extract also exhibited significant antioxidant activities compared to the non-optimized extraction. Metabolomic phytochemical profiles and targeted phytochemical analyses showed that kaempferol, quercetin, and their derivatives as well as rosmarinic acid were abundant in the extract. The optimized DE extract also acted synergistically with donepezil, an AD drug suppressing BACE-1 activities. Data received from Drosophila-expressing human amyloid precursor proteins (APPs) and BACE-1, representing the amyloid hypothesis, showed that the optimized DE extract penetrated the fly brains, suppressed BACE-1 activities, and improved locomotor functions. The extract quenched the expression of glutathione S transferase D1 (GSTD1), inositol-requiring enzyme (IRE-1), and molecular chaperone-binding immunoglobulin (Bip), while donepezil suppressed these genes and other genes involved in antioxidant and endoplasmic reticulum (ER) stress response, including superoxide dismutase type 1 (SOD1), activating transcription factor 6 (ATF-6), and protein kinase R-like endoplasmic reticulum kinase (PERK). To sum up, the optimized extraction condition reduced extraction time while resulting in higher phytochemicals, antioxidants, and BACE-1 inhibitors. Full article
(This article belongs to the Special Issue Phytochemical Profile and Biological Evaluation of Plant Extracts)
13 pages, 408 KiB  
Article
Increased Erythrocyte Sedimentation Rate in Dogs: Frequency in Routine Clinical Practice and Association with Hematological Changes
by Saverio Paltrinieri, Roberta Ferrari, Donatella Scavone, Carolina Pieroni, Daniela Diamanti and Filippo Tagliasacchi
Animals 2024, 14(10), 1409; https://doi.org/10.3390/ani14101409 (registering DOI) - 08 May 2024
Abstract
(1) Background: the erythrocyte sedimentation rate (ESR) has been reported to increase in some infectious or inflammatory diseases in dogs, but no information on the frequency of increases in a routine clinical setting exists. The aim of this study was to assess the [...] Read more.
(1) Background: the erythrocyte sedimentation rate (ESR) has been reported to increase in some infectious or inflammatory diseases in dogs, but no information on the frequency of increases in a routine clinical setting exists. The aim of this study was to assess the frequency of an increased ESR in dogs and to investigate its possible association with hematologic changes; (2) Methods: A total of 295 EDTA blood samples were randomly selected from the routine caseload of the Veterinary Teaching Hospital. Samples were grouped in controls and in pathologic groups based on the clinical presentation. A routine hemogram was performed, then the ESR was measured using the instrument MINI-PET; (3) Results: compared with controls, the ESR was significantly higher in all the pathologic groups, except for the hematological disorders group. The highest ESR was found in samples from dogs with chronic kidney disease or inflammation, followed by those from dogs with mild chronic disorders, severe/acute diseases, tumors and urinary disorders. The ESR negatively correlated with hematocrit and positively with neutrophil counts. (4) Conclusions: The ESR increases more frequently in dogs with clinically evident inflammation or CKD, but also in several other conditions, likely as a consequence of anemia and acute phase response. Full article
(This article belongs to the Section Veterinary Clinical Studies)
23 pages, 3122 KiB  
Article
Wall-Proximity Effects on Five-Hole Probe Measurements
by Adrien Vasseur, Nicolas Binder, Fabrizio Fontaneto and Jean-Louis Champion
Int. J. Turbomach. Propuls. Power 2024, 9(2), 16; https://doi.org/10.3390/ijtpp9020016 (registering DOI) - 08 May 2024
Abstract
Wall proximity affects the accuracy of pressure probe measurements with a particularly strong impact on multi-hole probes. The wall-related evolution of the calibration of two hemispheric L-shaped 3D-printed five-hole probes was investigated in a low-speed wind tunnel. Pressure measurements and 2D particle image [...] Read more.
Wall proximity affects the accuracy of pressure probe measurements with a particularly strong impact on multi-hole probes. The wall-related evolution of the calibration of two hemispheric L-shaped 3D-printed five-hole probes was investigated in a low-speed wind tunnel. Pressure measurements and 2D particle image velocimetry were performed. The wall proximity causes the probe to measure a flow diverging from the wall, whereas the boundary layer causes the probe to measure a velocity directed towards the wall. Both angular calibration coefficients are affected in different manners. The error in angle measurement can reach 7°. These errors can be treated as calibration information. Acceleration caused by blockage is not the main reason for the errors. Methods to perform measurements closer to the wall are suggested. Full article
14 pages, 882 KiB  
Article
Influence of Nonionic Surfactants on the Adsorption and Elution of Atrazine in Agriculturally Modified Soils
by Na Zhao and Chengjian Yang
Agriculture 2024, 14(5), 733; https://doi.org/10.3390/agriculture14050733 (registering DOI) - 08 May 2024
Abstract
The Hetao Irrigation District, situated in the Northwest of China, serves as a significant commercial grain base. Widespread use of atrazine, an herbicide in the region, has resulted in significant environmental issues, impacting the ecosystem equilibrium and sustainable agricultural development. The co-adsorption of [...] Read more.
The Hetao Irrigation District, situated in the Northwest of China, serves as a significant commercial grain base. Widespread use of atrazine, an herbicide in the region, has resulted in significant environmental issues, impacting the ecosystem equilibrium and sustainable agricultural development. The co-adsorption of the globally employed atrazine herbicide along with two nonionic surfactants, Tween-80 and Brij30, onto soils treated with HCl and H2O2 was investigated. The study revealed that the adsorption isothermal curves of surfactants on soil adhered to a two-stage adsorption model. Various types of adsorption isothermal curves, such as S-type or L-type, influenced the adsorption capacity of atrazine on the soil. Observations indicated that S-type or L-type isothermal curves of surfactants interconverted with alterations in soil polarity. Moreover, it has been uncovered that the adsorption properties of Tween 80 in the soil are intricately connected to its ability to elute atrazine within the same soil. This discovery provides theoretical support for a prudent reduction in herbicide usage in the Hetao Irrigation District in the upcoming years. Full article
(This article belongs to the Section Agricultural Soils)
9 pages, 397 KiB  
Article
Risk Factors and Outcomes of Patients Colonized with KPC and NDM Carbapenemase-Producing Enterobacterales
by Lisa Saidel-Odes, Orli Sagi, Shani Troib, Hannah Leeman, Ronit Nativ, Tal Schlaeffer-Yosef, Hovav Azulay, Lior Nesher and Abraham Borer
Antibiotics 2024, 13(5), 427; https://doi.org/10.3390/antibiotics13050427 (registering DOI) - 08 May 2024
Abstract
Carbapenemase-producing enterobacterales (CPE) poses an increasing threat in hospitals worldwide. Recently, the prevalence of different carbapenemases conferring carbapenem resistance in enterobacterales changed in our country, including an increase in New Delhi Metallo-beta-lactamase (NDM)-CPE. We conducted a comparative historical study of adult patients colonized [...] Read more.
Carbapenemase-producing enterobacterales (CPE) poses an increasing threat in hospitals worldwide. Recently, the prevalence of different carbapenemases conferring carbapenem resistance in enterobacterales changed in our country, including an increase in New Delhi Metallo-beta-lactamase (NDM)-CPE. We conducted a comparative historical study of adult patients colonized with Klebsiella pneumoniae carbapenemase (KPC)-CPE (July 2016 to June 2018, a historical cohort) vs. NDM-CPE (July 2016 to January 2023). We identified patients retrospectively through the microbiology laboratory and reviewed their files, extracting demographics, underlying diseases, Charlson Comorbidity Index (CCI) scores, treatments, and outcomes. This study included 228 consecutive patients from whom a CPE rectal swab screening was obtained: 136 NDM-CPE positive and 92 KPC-CPE positive. NDM-CPE-colonized patients had a shorter hospitalization length and a significantly lower 30-day post-discharge mortality rate (p = 0.002) than KPC-CPE-colonized patients. Based on multivariate regression, independent risk factors predicting CPE-NDM colonization included admission from home and CCI < 4 (p < 0.001, p = 0.037, respectively). The increase in NDM-CPE prevalence necessitates a modified CPE screening strategy upon hospital admission tailored to the changing local CPE epidemiology. In our region, the screening of younger patients residing at home with fewer comorbidities should be considered, regardless of a prior community healthcare contact or hospital admission. Full article
(This article belongs to the Special Issue Epidemiology and Characterization of Bacteria Isolated from Hospital)
14 pages, 1411 KiB  
Article
Quantification of Recycled PET in Commercial Bottles by IR Spectroscopy and Chemometrics
by Alessandro Zappi, Alessandra Biancolillo, Nicholas Kassouf, Valentina Marassi, Pietro Morozzi, Laura Tositti and Dora Melucci
Analytica 2024, 5(2), 219-232; https://doi.org/10.3390/analytica5020014 (registering DOI) - 08 May 2024
Abstract
A novel approach for the quantification of recycled polyethylene terephthalate (r-PET) in commercial bottles is presented. Fifty-eight bottle samples from several brands and producers containing different percentages of r-PET were purchased from the market. Samples were analyzed by two spectroscopic methods: near-infrared (NIR) [...] Read more.
A novel approach for the quantification of recycled polyethylene terephthalate (r-PET) in commercial bottles is presented. Fifty-eight bottle samples from several brands and producers containing different percentages of r-PET were purchased from the market. Samples were analyzed by two spectroscopic methods: near-infrared (NIR) spectroscopy and attenuated total reflection (ATR) spectroscopy in the mid-infrared (MIR) region. No chemical pre-treatment was applied before analyses. The spectra were analyzed by partial-least squares (PLS) regression, and two models for NIR and MIR data were computed. Then, a multi-block regression was applied to join the two datasets. All models were validated by cross-validation and by excluding and projecting onto the model the replicated spectra of one sample at a time. Results demonstrated the potential of this approach, especially considering the variability of commercial samples in terms of additives, shape, or thickness of the bottles: for samples close to the centroids of the models (i.e., from 10 to 50% r-PET), the predictions of multi-block method seldom departed from the expected values of ±10%. Only for samples with 0% declared r-PET, the models showed poor prediction abilities. Full article
(This article belongs to the Section Chemometrics)
29 pages, 957 KiB  
Article
How Does Low-Carbon Financial Policy Affect Corporate Green Innovation?—Re-Examination of Institutional Characteristics, Influence Mechanisms, and Local Government Behavior
by Hailin Yao, Zeyi Wan, Huixiang Zeng and Qingfang Wu
Sustainability 2024, 16(10), 3944; https://doi.org/10.3390/su16103944 (registering DOI) - 08 May 2024
Abstract
This paper employs a propensity score matching approach to construct a control group and estimate the impact of the CETS pilot policy, a low-carbon financial policy, on corporate green innovation and its impact mechanism in a difference-in-difference manner. The results show that the [...] Read more.
This paper employs a propensity score matching approach to construct a control group and estimate the impact of the CETS pilot policy, a low-carbon financial policy, on corporate green innovation and its impact mechanism in a difference-in-difference manner. The results show that the CETS pilot policy has a significantly positive effect on corporate green innovation. The higher the penalty degree and the carbon price, the more obvious the promotion of the green innovation of pilot enterprises. The mechanism test shows that the improvement of corporate green innovation is mainly due to the incentive effect rather than the anti-driving effect of the CETS pilot policy, that is, the policy promotes corporate green innovation by providing innovation resources and enhancing the willingness to innovate. Further analysis shows that only in regions where local governments have less competitive pressure can the CETS pilot policy effectively promote enterprise innovation resources and that a close and clean government–business relationship can help strengthen the promotion effect of the CETS pilot policy on the willingness of enterprises to innovate. Furthermore, this paper introduces its theoretical framework as a strategic tripod to explore the friction in the process of the CETS pilot policy affecting corporate green innovation from the perspective of the industry environment and corporate resources. This research shows that a lack of industry green technology and corporate human capital may hinder the positive impact of the CETS pilot policy on corporate green innovation. Finally, this study found that the CETS pilot policy has no significant impact on the quality of corporate green innovation, and the lack of industry green technology and corporate human capital may hinder the CETS pilot policy from improving the quality of corporate green innovation. Full article
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30 pages, 2616 KiB  
Article
Experimental Validation of Electrothermal and Aging Parameter Identification for Lithium-Ion Batteries
by Francesco Conte, Marco Giallongo, Daniele Kaza, Gianluca Natrella, Ryohei Tachibana, Shinji Tsuji, Federico Silvestro and Giovanni Vichi
Energies 2024, 17(10), 2269; https://doi.org/10.3390/en17102269 (registering DOI) - 08 May 2024
Abstract
Modeling and predicting the long-term performance of Li-ion batteries is crucial for the effective design and efficient operation of integrated energy systems. In this paper, we introduce a comprehensive semi-empirical model for Li-ion cells, capturing electrothermal and aging features. This model replicates the [...] Read more.
Modeling and predicting the long-term performance of Li-ion batteries is crucial for the effective design and efficient operation of integrated energy systems. In this paper, we introduce a comprehensive semi-empirical model for Li-ion cells, capturing electrothermal and aging features. This model replicates the evolution of cell voltage, capacity, and internal resistance, in relation to the cell actual operating conditions, and estimates the ongoing degradation in capacity and internal resistance due to the battery use. Thus, the model articulates into two sub-models, an electrothermal one, describing the battery voltage, and an aging one, computing the ongoing degradation. We first propose an approach to identify the parameters of both sub-models. Then, we validate the identification procedure and the accuracy of the electrothermal and aging models through an experimental campaign, also comprising two real cycle load tests at different temperatures, in which real measurements collected from real Li-ion cells are used. The overall model demonstrates good performances in simulating battery characteristics and forecasting degradation. The results show a Mean Absolute Percentage Error (MAPE) lower than 1% for battery voltage and capacity, and a maximum absolute error on internal resistance that is on par with the most up-to-date empirical models. The proposed approach is therefore well-suited for implementation in system modeling, and can be employed as an informative tool for enhancing battery design and operational strategies. Full article
(This article belongs to the Section D2: Electrochem: Batteries, Fuel Cells, Capacitors)
21 pages, 2750 KiB  
Article
Model-Predictive-Control-Based Centralized Disturbance Suppression Strategy for Distributed Drive Electric Vehicle
by Aiping Tan, Lixiao Gao and Yanfeng Chen
Energies 2024, 17(10), 2268; https://doi.org/10.3390/en17102268 (registering DOI) - 08 May 2024
Abstract
This paper presents a centralized disturbance suppression strategy for distributed drive electric vehicles which is based on model predictive direct motion control. This strategy is capable of addressing issues such as parameter uncertainties and external disturbances in vehicles. Firstly, the paper provides a [...] Read more.
This paper presents a centralized disturbance suppression strategy for distributed drive electric vehicles which is based on model predictive direct motion control. This strategy is capable of addressing issues such as parameter uncertainties and external disturbances in vehicles. Firstly, the paper provides a brief introduction to model predictive direct motion control. Secondly, it analyzes the impact of vehicle parameter uncertainties and external disturbances on the mathematical model. Finally, a centralized disturbance suppression strategy based on a sliding mode observer is proposed. Simulation results demonstrate that this strategy exhibits excellent disturbance rejection capabilities. Full article
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26 pages, 21778 KiB  
Article
The Optimal Infrastructure Design for Grid-to-Vehicle (G2V) Service: A Case Study Based on the Monash Microgrid
by Soobok Yoon and Roger Dargaville
Energies 2024, 17(10), 2267; https://doi.org/10.3390/en17102267 (registering DOI) - 08 May 2024
Abstract
The electrification of the transport sector has emerged as a game changer in addressing the issues of climate change caused by global warming. However, the unregulated expansion and simplistic approach to electric vehicle (EV) charging pose substantial risks to grid stability and efficiency. [...] Read more.
The electrification of the transport sector has emerged as a game changer in addressing the issues of climate change caused by global warming. However, the unregulated expansion and simplistic approach to electric vehicle (EV) charging pose substantial risks to grid stability and efficiency. Intelligent charging techniques using Information and Communication Technology, known as smart charging, enable the transformation of the EV fleets from passive consumers to active participants within the grid ecosystem. This concept facilitates the EV fleet’s contribution to various grid services, enhancing grid functionality and resilience. This paper investigates the optimal infrastructure design for a smart charging system within the Monash microgrid (Clayton campus). We introduce a centralized Grid-to-Vehicle (G2V) algorithm and formulate three optimization problems utilizing linear and least-squares programming methods. These problems address tariff structures between the main grid and microgrid, aiming to maximize aggregator profits or minimize load fluctuations while meeting EV users’ charging needs. Additionally, our framework incorporates network-aware coordination via the Newton–Raphson method, leveraging EVs’ charging flexibility to mitigate congestion and node voltage issues. We evaluate the G2V algorithm’s performance under increasing EV user demand through simulation and analyze the net present value (NPV) over 15 years. The results highlight the effectiveness of our proposed framework in optimizing grid operation management. Moreover, our case study offers valuable insights into an efficient investment strategy for deploying the G2V system on campus. Full article
(This article belongs to the Special Issue Advanced Optimization Strategy of Electric Vehicle and Smart Grids)

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