The 2023 MDPI Annual Report has
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31 pages, 3425 KiB  
Article
Production and Optimisation of Fermented Pumpkin-Based Mature Coconut Water Kefir Beverage Using Response Surface Methodology
by Wee Yin Koh, Xiao Xian Lim, Ban Hock Khor, Babak Rasti, Thuan Chew Tan, Rovina Kobun and Utra Uthumporn
Beverages 2024, 10(2), 34; https://doi.org/10.3390/beverages10020034 (registering DOI) - 07 May 2024
Abstract
Fermentation of pumpkin puree and mature coconut water using water kefir grains is a potential method for producing a novel functional non-dairy-based probiotic drink. In the present study, response surface methodology based on Box–Behnken design (RSM-BBD) was used to optimise fermentation temperature and [...] Read more.
Fermentation of pumpkin puree and mature coconut water using water kefir grains is a potential method for producing a novel functional non-dairy-based probiotic drink. In the present study, response surface methodology based on Box–Behnken design (RSM-BBD) was used to optimise fermentation temperature and substrates’ concentrations. The optimised fermentation temperature, pumpkin puree, and brown sugar concentrations of pumpkin-based mature coconut water kefir beverage (PWKC) were 27 °C, 20%, and 10% w/v, respectively. The optimised PWKC (PWKCopt) obtained an overall acceptability (OA) score of 4.03, with a desirable Lactobacillus count (6.41 Log CFU/mL), 0.68% v/v lactic acid content, 31% of water kefir grains’ biomass growth rate, and fermentation time (to reach pH 4.5) of 4.5 h. The optimized beverage, PWKCopt, contained 3.26% proteins, 2.75% dietary fibre, 2186.33 mg/L of potassium, 180.67 mg/L phosphorus, and 137.33 mg/L calcium and had a total phenolic content of 89.93 mg GAE/100 mL, flavonoid content of 49.94 mg QE/100 mL, and carotenoid content of 33.24 mg/100 mL, with antioxidant activity (FRAP: 169.17 mM Fe(II)/100 mL, IC50 value of DPPH free radicals scavenging activity: 27.17 mg/mL). Water kefir microorganisms in PWKCopt remained stable for at least 56 days at 4 °C. Therefore, PWKCopt might potentially serve as a value-added product, offering a basis for sustainable development within both the coconut and pumpkin industries. Full article
(This article belongs to the Topic Advances in Analysis of Food and Beverages)
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20 pages, 5088 KiB  
Article
Building Information Modeling/Building Energy Simulation Integration Based on Quantitative and Interpretative Interoperability Analysis
by Carolina Fernandes Vaz, Luísa Lopes de Freitas Guilherme, Ana Carolina Fernandes Maciel, André Luis De Araujo, Bruno Barzellay Ferreira Da Costa and Assed Naked Haddad
Infrastructures 2024, 9(5), 84; https://doi.org/10.3390/infrastructures9050084 (registering DOI) - 07 May 2024
Abstract
The integration between the building information modeling (BIM) methodology and the building energy simulation (BES) can contribute to a thermo-energetic analysis since the model generated and fed into BIM is exported to simulation software. This integration, also called interoperability, is satisfactory when the [...] Read more.
The integration between the building information modeling (BIM) methodology and the building energy simulation (BES) can contribute to a thermo-energetic analysis since the model generated and fed into BIM is exported to simulation software. This integration, also called interoperability, is satisfactory when the information flow is carried out without the loss of essential information. Several studies point out interoperability flaws between the methodologies; however, most of them occur in low-geometry-complexity models during quantitative experiments. The purpose of this research was to analyze the BIM/BES integration based on a quantitative and interpretative interoperability analysis of two buildings with complex geometries located on the UFU Campus (library and Building 5T) in Uberlândia, Brazil. To accomplish this, two geometries of each building were modeled, detailed, and simplified to analyze the data import, workflow, and model correction in the BES software. In the case of the library, the integration of Revit with DesignBuilder and IES-VE was analyzed, and in Block 5T, Revit was used with DesignBuilder and eQUEST. The BES software that presented the best integration with Revit for complex geometries was DesignBuilder, with the best performance being in the interpretative criteria. It was concluded that the simplification of complex geometries is essential for better data transfers. To determine the BES software that has better integration with BIM, a comprehensive evaluation is necessary, considering not only data transfers but also ease of working within BES software, the possibility of corrections in these, as well as the availability of tutorials and developer support. Full article
(This article belongs to the Special Issue Smart, Sustainable and Resilient Infrastructures, 2nd Edition)
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25 pages, 2921 KiB  
Article
Optimization of an IPMSM for Constant-Angle Square-Wave Control of a BLDC Drive
by Mitja Garmut, Simon Steentjes and Martin Petrun
Mathematics 2024, 12(10), 1418; https://doi.org/10.3390/math12101418 (registering DOI) - 07 May 2024
Abstract
Interior permanent magnet synchronous machines (IPMSMs) driven with a square-wave control (i.e., six-step, block, or 120 control), known commonly as brushless direct current (BLDC) drives, are used widely due to their high power density and control simplicity. The advance firing (AF) angle [...] Read more.
Interior permanent magnet synchronous machines (IPMSMs) driven with a square-wave control (i.e., six-step, block, or 120 control), known commonly as brushless direct current (BLDC) drives, are used widely due to their high power density and control simplicity. The advance firing (AF) angle is employed to achieve improved operation characteristics of the drive. The AF angle is, in general, applied to compensate for the commutation effects. In the case of an IPMSM, the AF angle can also be adjusted to exploit reluctance torque. In this paper, a detailed study was performed to understand its effect on the drive’s performance in regard to reluctance torque. Furthermore, a multi-objective optimization of the machine’s cross-section using neural network models was conducted to enhance performance at a constant AF angle. The reference and improved machine designs were evaluated in a system-level simulation, where the impact was considered of the commutation of currents. A significant improvement in the machine performance was achieved after optimizing the geometry and implementing a fixed AF angle of 10. Full article
32 pages, 1552 KiB  
Article
Mechanics 4.0 and Mechanical Engineering Education
by Eusebio Jiménez López, Pablo Alberto Limon Leyva, Armando Ambrosio López, Francisco Javier Ochoa Estrella, Juan José Delfín Vázquez, Baldomero Lucero Velázquez and Víctor Manuel Martínez Molina
Machines 2024, 12(5), 320; https://doi.org/10.3390/machines12050320 (registering DOI) - 07 May 2024
Abstract
Industry 4.0 is an industrial paradigm that is causing changes in form and substance in factories, companies and businesses around the world and is impacting work and education in general. In fact, the disruptive technologies that frame the Fourth Industrial Revolution have the [...] Read more.
Industry 4.0 is an industrial paradigm that is causing changes in form and substance in factories, companies and businesses around the world and is impacting work and education in general. In fact, the disruptive technologies that frame the Fourth Industrial Revolution have the potential to improve and optimize manufacturing processes and the entire value chain, which could lead to an exponential evolution in the production and distribution of goods and services. All these changes imply that the fields of engineering knowledge must be oriented towards the concept of Industry 4.0, for example, Mechanical Engineering. The development of various physical assets that are used by cyber-physical systems and digital twins is based on mechanics. However, the specialized literature on Industry 4.0 says little about the importance of mechanics in the new industrial era, and more importance is placed on the evolution of Information and Communication Technologies and artificial intelligence. This article presents a frame of reference for the importance of Mechanical Engineering in Industry 4.0 and proposes an extension to the concept of Mechanics 4.0, recently defined as the relationship between mechanics and artificial intelligence. To analyze Mechanical Engineering in Industry 4.0, the criteria of the four driving forces that defined mechanics in the Third Industrial Revolution were used. An analysis of Mechanical Engineering Education in Industry 4.0 is presented, and the concept of Mechanical Engineering 4.0 Education is improved. Finally, the importance of making changes to the educational models of engineering education is described. Full article
(This article belongs to the Section Robotics, Mechatronics and Intelligent Machines)
17 pages, 2769 KiB  
Article
Osteosarcoma-Induced Pain Is Mediated by Glial Cell Activation in the Spinal Dorsal Horn, but Not Capsaicin-Sensitive Nociceptive Neurons: A Complex Functional and Morphological Characterization in Mice
by Noémi Bencze, Bálint Scheich, Éva Szőke, Imola Wilhelm, Sándor Körmöndi, Bálint Botz and Zsuzsanna Helyes
Cancers 2024, 16(10), 1788; https://doi.org/10.3390/cancers16101788 (registering DOI) - 07 May 2024
Abstract
Bone cancer and its related chronic pain are huge clinical problems since the available drugs are often ineffective or cannot be used long term due to a broad range of side effects. The mechanisms, mediators and targets need to be identified to determine [...] Read more.
Bone cancer and its related chronic pain are huge clinical problems since the available drugs are often ineffective or cannot be used long term due to a broad range of side effects. The mechanisms, mediators and targets need to be identified to determine potential novel therapies. Here, we characterize a mouse bone cancer model induced by intratibial injection of K7M2 osteosarcoma cells using an integrative approach and investigate the role of capsaicin-sensitive peptidergic sensory nerves. The mechanical pain threshold was assessed by dynamic plantar aesthesiometry, limb loading by dynamic weight bearing, spontaneous pain-related behaviors via observation, knee diameter with a digital caliper, and structural changes by micro-CT and glia cell activation by immunohistochemistry in BALB/c mice of both sexes. Capsaicin-sensitive peptidergic sensory neurons were defunctionalized by systemic pretreatment with a high dose of the transient receptor potential vanilloid 1 (TRPV1) agonist resiniferatoxin (RTX). During the 14- and 28-day experiments, weight bearing on the affected limb and the paw mechanonociceptive thresholds significantly decreased, demonstrating secondary mechanical hyperalgesia. Signs of spontaneous pain and osteoplastic bone remodeling were detected both in male and female mice without any sex differences. Microglia activation was shown by the increased ionized calcium-binding adapter molecule 1 (Iba1) immunopositivity on day 14 and astrocyte activation by the enhanced glial fibrillary acidic protein (GFAP)-positive cell density on day 28 in the ipsilateral spinal dorsal horn. Interestingly, defunctionalization of the capsaicin-sensitive afferents representing approximately 2/3 of the nociceptive fibers did not alter any functional parameters. Here, we provide the first complex functional and morphological characterization of the K7M2 mouse osteosarcoma model. Bone-cancer-related chronic pain and hyperalgesia are likely to be mediated by central sensitization involving neuroinflammation via glial cell activation in the spinal dorsal horn, but not the capsaicin-sensitive sensory neuronal system. Full article
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27 pages, 1366 KiB  
Article
A Set of Accurate Dispersive Nonlinear Wave Equations
by Hongwei Bian, Jie Xu and Zhili Zou
J. Mar. Sci. Eng. 2024, 12(5), 778; https://doi.org/10.3390/jmse12050778 (registering DOI) - 07 May 2024
Abstract
In this study, a set of accurate dispersive nonlinear wave equations is established, using the wave velocity and free surface elevation as variables. These equations improve upon previous equations in which the velocity potential is used as a variable by considering the rotational [...] Read more.
In this study, a set of accurate dispersive nonlinear wave equations is established, using the wave velocity and free surface elevation as variables. These equations improve upon previous equations in which the velocity potential is used as a variable by considering the rotational wave motion and by adding a second-order bottom slope term that applies to general situations, allowing the equations to consider the influence of rapidly changing, horizontal, two-dimensional bottom topographies. The problem of the inaccuracy of the integral calculations used in previous equations in nearshore areas is solved by approximating the integral calculations into differential calculations, and a set of coupled wave equations is established by keeping the free surface elevation and the horizontal velocity constant, thus allowing the calculation of nearshore wave-generated currents. The benefits of the current model are confirmed through comparisons with corresponding laboratory experimental findings and are illustrated through a comparison with the numerical outcomes of other pertinent models. Full article
(This article belongs to the Section Ocean Engineering)
19 pages, 2614 KiB  
Article
Numerical Simulation and Deformation Prediction of Deep Pit Based on PSO-BP Neural Network Inversion of Soil Parameters
by Qingwang Li, Feng Cheng and Xinran Zhang
Sensors 2024, 24(10), 2959; https://doi.org/10.3390/s24102959 (registering DOI) - 07 May 2024
Abstract
The finite element numerical simulation results of deep pit deformation are greatly influenced by soil layer parameters, which are crucial in determining the accuracy of deformation prediction results. This study employs the orthogonal experimental design to determine the combinations of various soil layer [...] Read more.
The finite element numerical simulation results of deep pit deformation are greatly influenced by soil layer parameters, which are crucial in determining the accuracy of deformation prediction results. This study employs the orthogonal experimental design to determine the combinations of various soil layer parameters in deep pits. Displacement values at specific measurement points were calculated using PLAXIS 3D under these varying parameter combinations to generate training samples. The nonlinear mapping ability of the Back Propagation (BP) neural network and Particle Swarm Optimization (PSO) were used for sample global optimization. Combining these with actual onsite measurements, we inversely calculate soil layer parameter values to update the input parameters for PLAXIS 3D. This allows us to conduct dynamic deformation prediction studies throughout the entire excavation process of deep pits. The results indicate that the use of the PSO-BP neural network for inverting soil layer parameters effectively enhances the convergence speed of the BP neural network model and avoids the issue of easily falling into local optimal solutions. The use of PLAXIS 3D to simulate the excavation process of the pit accurately reflects the dynamic changes in the displacement of the retaining structure, and the numerical simulation results show good agreement with the measured values. By updating the model parameters in real-time and calculating the pile displacement under different working conditions, the absolute errors between the measured and simulated values of pile top vertical displacement and pile body maximum horizontal displacement can be effectively reduced. This suggests that inverting soil layer parameters using measured values from working conditions is a feasible method for dynamically predicting the excavation process of the pit. The research results have some reference value for the selection of soil layer parameters in similar areas. Full article
(This article belongs to the Section Smart Agriculture)
19 pages, 545 KiB  
Review
An Overview of Approaches and Methods for the Cognitive Workload Estimation in Human–Machine Interaction Scenarios through Wearables Sensors
by Sabrina Iarlori, David Perpetuini, Michele Tritto, Daniela Cardone, Alessandro Tiberio, Manish Chinthakindi, Chiara Filippini, Luca Cavanini, Alessandro Freddi, Francesco Ferracuti, Arcangelo Merla and Andrea Monteriù
BioMedInformatics 2024, 4(2), 1155-1173; https://doi.org/10.3390/biomedinformatics4020064 (registering DOI) - 07 May 2024
Abstract
Background: Human-Machine Interaction (HMI) has been an important field of research in recent years, since machines will continue to be embedded in many human actvities in several contexts, such as industry and healthcare. Monitoring in an ecological mannerthe cognitive workload (CW) of users, [...] Read more.
Background: Human-Machine Interaction (HMI) has been an important field of research in recent years, since machines will continue to be embedded in many human actvities in several contexts, such as industry and healthcare. Monitoring in an ecological mannerthe cognitive workload (CW) of users, who interact with machines, is crucial to assess their level of engagement in activities and the required effort, with the goal of preventing stressful circumstances. This study provides a comprehensive analysis of the assessment of CW using wearable sensors in HMI. Methods: this narrative review explores several techniques and procedures for collecting physiological data through wearable sensors with the possibility to integrate these multiple physiological signals, providing a multimodal monitoring of the individuals’CW. Finally, it focuses on the impact of artificial intelligence methods in the physiological signals data analysis to provide models of the CW to be exploited in HMI. Results: the review provided a comprehensive evaluation of the wearables, physiological signals, and methods of data analysis for CW evaluation in HMI. Conclusion: the literature highlighted the feasibility of employing wearable sensors to collect physiological signals for an ecological CW monitoring in HMI scenarios. However, challenges remain in standardizing these measures across different populations and contexts. Full article
(This article belongs to the Special Issue Feature Papers in Applied Biomedical Data Science)
25 pages, 3629 KiB  
Article
Performance Optimization Design Study of Box-Type Substations Subjected to the Combined Effects of Wind, Snow, and Seismic Loads
by Meixing Guo, Mingzhu Fang, Lingyu Wang, Jie Hu and Jin Qi
Appl. Sci. 2024, 14(10), 3958; https://doi.org/10.3390/app14103958 (registering DOI) - 07 May 2024
Abstract
As a pivotal node in both urban and rural power grids, the box-type substation not only serves the functions of power conversion and distribution but also need to provide structural support and environmental adaptability. However, deficiencies in strength, stiffness, or vibration characteristics may [...] Read more.
As a pivotal node in both urban and rural power grids, the box-type substation not only serves the functions of power conversion and distribution but also need to provide structural support and environmental adaptability. However, deficiencies in strength, stiffness, or vibration characteristics may lead to vibration and noise issues, and extreme environmental changes can pose risks of structural damage. This study aims to verify and optimize the seismic resistance and environmental adaptability of box-type substations through finite element simulation methods. Using SOLIDWORKS, a three-dimensional model of the box-type substation was constructed, and static and dynamic analyses were conducted using Ansys Workbench to comprehensively evaluate the dynamic response of the box-type substation under wind, snow loads, and seismic action. Through iterative simulations and a comparison of multiple design solutions, the structural optimization of the substation was achieved. The optimized structure balances strength and stiffness, significantly reducing the weight of the substation body, with the wall thickness reduced by 60%. Additionally, the phenomenon of stress concentration on the side walls was eliminated, ensuring that the equivalent stress is below the material yield strength. This research provides methods and empirical results for enhancing the performance and reliability of box-type substations under seismic conditions, confirming the feasibility of a lightweight design, while ensuring structural safety. Full article
13 pages, 419 KiB  
Article
The Role of Coping Strategies in Children’s Repeated Suggestive Interviews
by Monia Vagni and Valeria Giostra
Forensic Sci. 2024, 4(2), 221-233; https://doi.org/10.3390/forensicsci4020015 (registering DOI) - 07 May 2024
Abstract
Often in the forensic context, child victims and witnesses are interviewed several times, exposing them to suggestive questions and social pressures. The present study had the main purpose of verifying the effect of coping strategies on the levels of immediate suggestibility and on [...] Read more.
Often in the forensic context, child victims and witnesses are interviewed several times, exposing them to suggestive questions and social pressures. The present study had the main purpose of verifying the effect of coping strategies on the levels of immediate suggestibility and on the Resistant Behavioral Responses (RBRs) of children subjected to repeated suggestive interviews. A sample of 90 children, aged between 11 and 14, were administered the two parallel Gudjonsson Suggestibility Scales (GSS2 and GSS1) a few months apart and the Coping Inventory for Stressful Situations (CISS) to detect their coping strategies. The results showed that the avoidance coping increased suggestive vulnerability and reduced resistant responses. Task-oriented coping favored responses with greater source monitoring, which allow for the rejection of misleading information. Coping strategies did not show direct effects on the management of the socioemotional aspects involved in the suggestive interaction. After the negative feedback that invites children to be more accurate, a smaller effect of the avoidance strategy was recorded, indicating how actively requesting greater source monitoring can lead children to better recognize misleading information. Full article
(This article belongs to the Special Issue Abuse and Violence in Families)
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20 pages, 8014 KiB  
Article
Exploring Olive Pit Powder as a Filler for Enhanced Thermal Insulation in Epoxy Mortars to Increase Sustainability in Building Construction
by Veronica D’Eusanio, Andrea Marchetti, Stefano Pastorelli, Michele Silvestri, Lucia Bertacchini and Lorenzo Tassi
AppliedChem 2024, 4(2), 192-211; https://doi.org/10.3390/appliedchem4020013 (registering DOI) - 07 May 2024
Abstract
This article explores the use of olive pit powder (OPP) as a promising resource for enhancing the thermal insulation properties of epoxy mortars. A comprehensive analysis of the chemical and physical characteristics of OPP was conducted, employing analytical techniques including scanning electron microscopy [...] Read more.
This article explores the use of olive pit powder (OPP) as a promising resource for enhancing the thermal insulation properties of epoxy mortars. A comprehensive analysis of the chemical and physical characteristics of OPP was conducted, employing analytical techniques including scanning electron microscopy (SEM), thermogravimetric analysis and emitted gas analysis (TG-MS-EGA), and proximal analysis. Experimental samples of epoxy grout were prepared by using different proportions of a conventional inorganic filler, quartz powder, and OPP within an epoxy mortar matrix. As the percentage of OPP in the formulation increased, the microstructure of the samples gradually became more porous and less compact. Consequently, there was a decrease in density with the increase in OPP content. The 28-day compressive strength decreased from 46 MPa to 12.8 MPa, respectively, in the samples containing only quartz (Sample E) and only OPP (Sample A) as a filler. Similarly, flexural strength decreased from 35.2 to 5.3 MPa. The thermal conductivity decreased from 0.3 W/mK in Sample E to 0.11 in Sample A. Therefore, increasing the %wt of OPP improved insulating properties while reducing the mechanical resistance values. This study highlights the potential of OPP as an environmentally friendly and thermally efficient filler for epoxy mortars, thereby promoting sustainable construction practices. Full article
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13 pages, 3419 KiB  
Article
Utilization of Waste Marble and Bi2O3-NPs as a Sustainable Replacement for Lead Materials for Radiation Shielding Applications
by Khalid Alsafi, Mohamed A. El-Nahal, Wafa M. Al-Saleh, Haifa M. Almutairi, Esraa H. Abdel-Gawad and Mohamed Elsafi
Ceramics 2024, 7(2), 639-651; https://doi.org/10.3390/ceramics7020042 (registering DOI) - 07 May 2024
Abstract
In an attempt to reutilize marble waste, a new approach is presented in the current study to promote its use in the field of shielding against ionizing radiation. In this study, we aimed to develop a novel and sustainable/eco-friendly lead-free radiation shielding material [...] Read more.
In an attempt to reutilize marble waste, a new approach is presented in the current study to promote its use in the field of shielding against ionizing radiation. In this study, we aimed to develop a novel and sustainable/eco-friendly lead-free radiation shielding material by improving artificial marble (AM) produced from marble waste combined with polyester by reinforcing it with bismuth oxide (Bi2O3) nanoparticles. Six samples of AM samples doped with different concentrations (0%, 5%, 10%, 15%, 20%, and 25%) of Bi2O3 nanoparticles were prepared. The linear attenuation coefficient (LAC) values were measured experimentally through the narrow beam method at different energies (0.0595 MeV, 0.6617 MeV, 1.1730 MeV, and 1.330 MeV) for all samples with various concentrations of Bi2O3. Radiological shielding parameters such as half value layer (HVL), tenth-value layer (TVL), and radiation shielding efficiency (RSE) were estimated and compared for all the different samples. The results prove that increasing the concentration of Bi2O3 leads to the enhancement of the radiation shielding properties of the AM as a shielding material. It was observed that as the energy increases, the efficiency of the samples falls. High energy dependence was found when calculating the HVL and TVL values of the samples, which increased with increases in the energy of the incident photons. A comparison between the sample with the most efficient gamma radiation attenuation capability (AM-25%), concrete, and lead was conducted, and a discussion regarding their radiation shielding properties is presented herein. The results show that the AM-25% sample is superior to the ordinary concrete over all the studied energy ranges, as evidenced by its significantly lower HVLs. On the contrary, lead is superior to the AM-25% sample over all the studied energy ranges owing to its unbeatable density as a shielding material. Overall, this new type of artificial marble has the potential to be used as a radiation shielding material at low- to medium-gamma energy regions, specifically in medical imaging and radiation therapy. Full article
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8 pages, 215 KiB  
Communication
Ethical Considerations for Artificial Intelligence Applications for HIV
by Renee Garett, Seungjun Kim and Sean D. Young
AI 2024, 5(2), 594-601; https://doi.org/10.3390/ai5020031 (registering DOI) - 07 May 2024
Abstract
Human Immunodeficiency Virus (HIV) is a stigmatizing disease that disproportionately affects African Americans and Latinos among people living with HIV (PLWH). Researchers are increasingly utilizing artificial intelligence (AI) to analyze large amounts of data such as social media data and electronic health records [...] Read more.
Human Immunodeficiency Virus (HIV) is a stigmatizing disease that disproportionately affects African Americans and Latinos among people living with HIV (PLWH). Researchers are increasingly utilizing artificial intelligence (AI) to analyze large amounts of data such as social media data and electronic health records (EHR) for various HIV-related tasks, from prevention and surveillance to treatment and counseling. This paper explores the ethical considerations surrounding the use of AI for HIV with a focus on acceptability, trust, fairness, and transparency. To improve acceptability and trust towards AI systems for HIV, informed consent and a Federated Learning (FL) approach are suggested. In regard to unfairness, stakeholders should be wary of AI systems for HIV further stigmatizing or even being used as grounds to criminalize PLWH. To prevent criminalization, in particular, the application of differential privacy on HIV data generated by data linkage should be studied. Participatory design is crucial in designing the AI systems for HIV to be more transparent and inclusive. To this end, the formation of a data ethics committee and the construction of relevant frameworks and principles may need to be concurrently implemented. Lastly, the question of whether the amount of transparency beyond a certain threshold may overwhelm patients, thereby unexpectedly triggering negative consequences, is posed. Full article
(This article belongs to the Special Issue Standards and Ethics in AI)
11 pages, 1413 KiB  
Article
Endoscopic Ultrasonography-Guided Fine-Needle Biopsy for Patients with Resectable Pancreatic Malignancies
by Ming-Sheng Chien, Ching-Chung Lin and Jian-Han Lai
Gastroenterol. Insights 2024, 15(2), 375-385; https://doi.org/10.3390/gastroent15020026 (registering DOI) - 07 May 2024
Abstract
Clinicians often use endoscopic ultrasonography to survey pancreatic tumors. When endoscopists conduct this examination and find the tumor to be unresectable, a fine-needle biopsy is subsequently performed for tissue confirmation. However, if the tumor is deemed resectable, the necessity of a pre-operative fine-needle [...] Read more.
Clinicians often use endoscopic ultrasonography to survey pancreatic tumors. When endoscopists conduct this examination and find the tumor to be unresectable, a fine-needle biopsy is subsequently performed for tissue confirmation. However, if the tumor is deemed resectable, the necessity of a pre-operative fine-needle biopsy remains debatable. Therefore, we performed a retrospective analysis of a single-center cohort of patients with pancreatic tumors who underwent an endoscopic ultrasound-guided fine-needle biopsy or aspiration (EUS-FNB or FNA) between 2020 and 2022. This study focused on patients diagnosed with resectable malignant pancreatic tumors. The exclusion criteria included individuals diagnosed with benign pancreatic lesions and those with unresectable tumors. A total of 68 patients were enrolled in this study. Histological examination revealed that pancreatic adenocarcinoma was the predominant type of tumor (n = 42, 61.8%), followed by neuroendocrine tumors (n = 22, 32.3%), and metastasis (n = 4, 5.9%). Notably, 17 patients had a history of other cancers, with 23.5% being diagnosed with a metastatic tumor rather than primary pancreatic cancer. Therefore, EUS-FNA/FNB is crucial in patients with a resectable pancreatic tumor and a history of cancer to differentiate between a primary and a metastatic tumor. Full article
(This article belongs to the Section Pancreas)
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14 pages, 561 KiB  
Review
Clinical and Paraclinical Considerations Regarding ki67’s Role in the Management of Differentiated Thyroid Carcinoma—A Literature Review
by Claudiu Peștean, Alexandru Pavel and Doina Piciu
Medicina 2024, 60(5), 769; https://doi.org/10.3390/medicina60050769 (registering DOI) - 07 May 2024
Abstract
Background and Objectives: The ki67 nuclear protein is a tool for diagnosis and prognosis in oncology that is used to evaluate cell proliferation. Differentiated thyroid carcinoma is usually a slow-growing neoplasm, the most common type being the papillary form. Some clinical and [...] Read more.
Background and Objectives: The ki67 nuclear protein is a tool for diagnosis and prognosis in oncology that is used to evaluate cell proliferation. Differentiated thyroid carcinoma is usually a slow-growing neoplasm, the most common type being the papillary form. Some clinical and pathological aspects may predict aggressive behaviour. There are reported cases of recurrence without clinico-pathological findings of aggressiveness. To obtain better predictions of the disease outcome in thyroid carcinoma, many immunohistochemical markers have been studied. The aim of this narrative literature review is to identify the benefits that ki67 may add to the management of patients with differentiated thyroid carcinoma, according to the latest evidence. Materials and Methods: We performed a search on the PubMed and Google Scholar databases using controlled vocabulary and keywords to find the most suitable published articles. A total number of sixty-eight items were identified, and five other articles were selected from other sources. After refining the selection, the inclusion criteria and exclusion criteria were applied, and a total number of twenty-nine articles were included in this literature review. Results and Discussion: The studies consist of retrospective studies (89.66%), case reports (6.9%) and literature reviews (3.45%), evaluating the role, implications and other parameters of ki67 as a diagnostic and/or prognostic tool. The statistical correlations between ki67 and other features were systematized as qualitative results of this review in order to improve the treatment strategies presented in the included articles. Conclusions: The included studies present converging data regarding most of the aspects concerning ki67. The ki67 proliferation index is a diagnostic/prognostic tool of interest in differentiated thyroid carcinoma and a good predictor of disease-free survival, disease recurrence and metastatic development. Prospective studies on large cohorts may add value for ki67 as a specific tool in the management strategy of differentiated thyroid carcinoma. Full article
(This article belongs to the Section Oncology)
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20 pages, 1348 KiB  
Review
Quality of Life of Dialysis Patients: Exploring the Influence of Membrane Hemocompatibility and Dialysis Practices on Psychosocial and Physical Symptoms
by Victoria Doan, Ahmed Shoker and Amira Abdelrasoul
J. Compos. Sci. 2024, 8(5), 172; https://doi.org/10.3390/jcs8050172 (registering DOI) - 07 May 2024
Abstract
Hemodialysis (HD) is a life-sustaining membrane-based therapy that is essential for managing kidney failure. However, it can have significant physical and psychological effects on patients due to chronic or acute consequences related to membrane bioincompatibility. End-stage renal disease (ESRD) patients on hemodialysis have [...] Read more.
Hemodialysis (HD) is a life-sustaining membrane-based therapy that is essential for managing kidney failure. However, it can have significant physical and psychological effects on patients due to chronic or acute consequences related to membrane bioincompatibility. End-stage renal disease (ESRD) patients on hemodialysis have a high incidence of psychiatric illness, particularly depression and anxiety disorders, and poor quality of life has been observed. Dialysis can also lead to physical symptoms of its own, such as fatigue, loss of appetite, anemia, low blood pressure, and fluid overload, in addition to the symptoms associated with kidney failure. Therefore, this critical review aims to comprehensively understand the impact of dialysis membrane bioincompatibility and the use of varying molecular weight cut-off membranes on the physical and psychological symptoms experienced by dialysis patients. We analyzed the latest research on the correlation between major inflammatory biomarkers released in patients’ blood due to membrane incompatibility, as well as the critical influence of low levels of hemoglobin and vital proteins such as human serum albumin due to the use of high-cut-off membranes and correlated these factors with the physical and psychological symptoms experienced by dialysis patients. Furthermore, our study aims to provide valuable insights into the impact of dialysis on critical symptoms, higher hospitalization rates, and the quality of life of First Nations, as well as child and youth dialysis patients, in addition to diabetic dialysis patients. Our goal is to identify potential interventions aiming to optimize the dialysis membrane and minimize its negative effects on patients, ultimately improving their well-being and long-term outcomes. Full article
(This article belongs to the Section Biocomposites)
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15 pages, 6034 KiB  
Article
Distributed-Drive Vehicle Lateral-Stability Coordinated Control Based on Phase-Plane Stability Region
by Jun Liu and Ang Dai
World Electr. Veh. J. 2024, 15(5), 202; https://doi.org/10.3390/wevj15050202 (registering DOI) - 07 May 2024
Abstract
The lateral stability control of vehicles is one of the most crucial aspects of vehicle safety. This article introduces a coordinated-control strategy designed to enhance the handling stability of distributed-drive electric vehicles. The upper controller uses active front steering and direct yaw moment-control [...] Read more.
The lateral stability control of vehicles is one of the most crucial aspects of vehicle safety. This article introduces a coordinated-control strategy designed to enhance the handling stability of distributed-drive electric vehicles. The upper controller uses active front steering and direct yaw moment-control controllers designed based on sliding-mode control theory. The lower controller optimally allocates control inputs to the upper controller, considering factors such as load transfer and tire load rate. It divides the stability region by relying on the phase plane and develops a coordinated-control strategy based on the degree of deviation of the vehicle state from the stability region. The results of the simulation experiments demonstrate that the proposed control strategy effectively improves handling stability under extreme working conditions. Full article
(This article belongs to the Special Issue Intelligent Electric Vehicle Control, Testing and Evaluation)
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19 pages, 3560 KiB  
Article
Functional or Neglected Border Regions? Analysis of the Integrated Development Plans of Borderland Municipalities in South Africa
by Thato L. Maila and Klára Czimre
Urban Sci. 2024, 8(2), 46; https://doi.org/10.3390/urbansci8020046 (registering DOI) - 07 May 2024
Abstract
The mainstream approach of regional integration impact assessments is mainly limited to assessing cross-border development projects/programmes. There is still a lack of critical assessment of how stakeholders at different institutional levels conceptualise the border. Local (municipal) strategic plans provide a reflection of the [...] Read more.
The mainstream approach of regional integration impact assessments is mainly limited to assessing cross-border development projects/programmes. There is still a lack of critical assessment of how stakeholders at different institutional levels conceptualise the border. Local (municipal) strategic plans provide a reflection of the spatial imaginaries of stakeholders, perception planners, institutional power structures, and, to some extent meaning of the border to the local people. Integrated Development Plans (IDPs) in South Africa were adopted as an important development planning strategy in the post-apartheid era. IDPs of 49 borderland municipalities were systematically reviewed using the Key-Word-in-Context (KWIC) content analysis technique of the keyword ‘border’ to determine the importance of state borders in light of regional integration. Border security and management is one of the most common themes associated with the border. This suggested that borders were mainly perceived as threats and barely considered as a potential resource for cross-border cooperation or integration. Full article
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19 pages, 1803 KiB  
Article
Eco-Sustainability of Soils in Baby-Leaf Crop Systems under Tunnel through the Application of C-Rich Inputs: Towards Combating Soil Degradation
by Enrica Picariello, Flavio Fornasier, Maurizio Bilotto, Emiliana Mignoli, Salvatore Baiano and Luigi Morra
Horticulturae 2024, 10(5), 476; https://doi.org/10.3390/horticulturae10050476 (registering DOI) - 07 May 2024
Abstract
Fresh-cut leafy vegetables are produced in Southern Italy in very intensive crop systems under tunnel greenhouses in which continuous cropping has triggered soil organic carbon (SOC) depletion and the risk of degradation of soil fertility. A two-year trial of soil organic amendment was [...] Read more.
Fresh-cut leafy vegetables are produced in Southern Italy in very intensive crop systems under tunnel greenhouses in which continuous cropping has triggered soil organic carbon (SOC) depletion and the risk of degradation of soil fertility. A two-year trial of soil organic amendment was carried out on a private farm producing baby-leaf crops on a very poor OC soil (<1%). Biowaste compost, two types of olive pomace composts and buffalo manure were compared to evaluate their ability to recover a positive SOC balance and sustain crop growth and yield. The effects on soil health and crop system were studied by measuring different aspects such as SOC stock change and SOC sequestration rate, soil microbial biomass and nine enzyme activities, yields of rocket and concentration of nitrates in leaves. Soil amendments were distributed once a year at doses of 15 and 30 Mg ha−1 as fresh matter without integration of mineral fertilizers. In our study, the SOC stock improved in the amended soils in a range of 4–6 Mg ha−1, except for dose 30 of buffalo manure, with the highest values where biowaste compost was applied. Our data showed an increase in biological parameters in all the amended soils with respect to Control. In soil amended with olive pomace, however, compost mineralization rates likely did not match crops’ nutrient needs so the yields of rocket were lower than with the biowaste compost and buffalo manure. Biowaste compost showed the best results as it balanced the best C conversion efficiency, the higher increment of SOC and yields of rocket. Full article
(This article belongs to the Section Plant Nutrition)
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15 pages, 2434 KiB  
Article
The Impact of Genotype and Controlled Environment Cultivation Parameters on Tomato-Leaf-Derived Exosome-like Nanoparticle Yield and Properties
by Akvilė Viršilė, Giedrė Samuolienė, Kristina Laužikė, Emilija Mikalauskienė, Zbigniev Balion and Aistė Jekabsone
Horticulturae 2024, 10(5), 477; https://doi.org/10.3390/horticulturae10050477 (registering DOI) - 07 May 2024
Abstract
Horticultural plant material offers several advantages for isolating exosomes and other natural plant-derived exosome-like nanoparticles (PDENs) due to the accessibility and affordability of plant material for widespread applications. This study aims to explore the impacts of the tomato genotype (‘Admiro’, ‘Roma’, ‘Brooklyn’, ‘Marmande’ [...] Read more.
Horticultural plant material offers several advantages for isolating exosomes and other natural plant-derived exosome-like nanoparticles (PDENs) due to the accessibility and affordability of plant material for widespread applications. This study aims to explore the impacts of the tomato genotype (‘Admiro’, ‘Roma’, ‘Brooklyn’, ‘Marmande’ and ‘Betalux’) and the main cultivation parameters in controlled environment agriculture on the yield and properties of their PDENs for pharmaceutical and cosmeceutical applications. The PDEN yield, size distribution, and antioxidative properties of young tomato seedlings were evaluated. The ‘Betalux’ tomato was distinguished by a remarkably higher nanoparticle concentration and a uniform size distribution and was selected for further experiments. The impact of cultivation temperature (18, 22, and 26 °C), nitrogen nutrition (0, 250, and 500 mg L−1), and the lighting photosynthetic photon flux density (PPFD; 150, 250, and 450 µmol m−2 s−1) on nanoparticle properties was investigated. Optimal conditions consisting of a temperature of 22 °C, 250 mg L−1 nitrogen nutrition, and 250 µmol m−2 s−1 lighting PPFD were used as a reference. Optimal temperature, nitrogen nutrition, and lighting intensity resulted in the highest nanoparticle yield, the most uniform particle distribution, and the highest impact of PDEN preparations on keratinocyte metabolic activity. Deviation from optimal cultivation conditions reduced the tomato biomass and the PDEN protein and yield. Full article
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10 pages, 2734 KiB  
Article
Improved Waterlogging Tolerance in Roots of Cucumber Plants after Inoculation with Arbuscular Mycorrhizal Fungi
by Nan Xiang, Zhen Liu, Xiao Tian, Dan Wang, Abeer Hashem, Elsayed Fathi Abd_Allah, Qiang-Sheng Wu and Ying-Ning Zou
Horticulturae 2024, 10(5), 478; https://doi.org/10.3390/horticulturae10050478 (registering DOI) - 07 May 2024
Abstract
Mycorrhizal symbiosis enhances host plant resistance to various unfavorable environmental stresses, but whether and how it also enhances waterlogging tolerance in cucumber plants is not known. The objective of this study was to analyze the effect of Paraglomus occultum inoculation on biomass production, [...] Read more.
Mycorrhizal symbiosis enhances host plant resistance to various unfavorable environmental stresses, but whether and how it also enhances waterlogging tolerance in cucumber plants is not known. The objective of this study was to analyze the effect of Paraglomus occultum inoculation on biomass production, osmolyte levels, and the expression of 12 heat shock protein 70 (Hsp70) genes and 14 plasma membrane intrinsic protein (PIP) genes in the roots of cucumber plants under a short-term waterlogging stress (WS) (5 days) condition. Although the short-term WS treatment significantly inhibited the arbuscular mycorrhizal fungal colonization of roots, the inoculation with arbuscular mycorrhizal fungi (AMFs) significantly increased leaf, stem, and root biomass under WS. AMF inoculation also significantly increased root glucose, sucrose, betaine, and proline contents, along with decreased fructose levels, compared with the uninoculated control. More CsHsp70 and CsPIP genes were up-regulated in AMF-inoculated plants than in AMF-uninoculated plants in response to WS. AMF inoculation showed no significant effect on the expression of any of the examined CsHsp70 genes under no-waterlogging stress, but it did raise the expression of 11 of 12 CsHsp70 genes under WS. AMF colonization also down-regulated or had no effect on CsPIP expression under no-waterlogging stress, whereas it up-regulated the expression of 12 of the 14 CsPIP genes under WS. It is concluded that AMF inoculation enhances waterlogging tolerance in cucumber plants by increasing osmolyte levels and stress-responsive gene (CsPIP and CsHsp70) expression. Full article
(This article belongs to the Special Issue Responses to Abiotic Stresses in Horticultural Crops—2nd Edition)
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29 pages, 15101 KiB  
Article
Multimodal Embodiment Research of Oral Music Traditions: Electromyography in Oud Performance and Education Research of Persian Art Music
by Stella Paschalidou
Multimodal Technol. Interact. 2024, 8(5), 37; https://doi.org/10.3390/mti8050037 (registering DOI) - 07 May 2024
Abstract
With the recent advent of research focusing on the body’s significance in music, the integration of physiological sensors in the context of empirical methodologies for music has also gained momentum. Given the recognition of covert muscular activity as a strong indicator of musical [...] Read more.
With the recent advent of research focusing on the body’s significance in music, the integration of physiological sensors in the context of empirical methodologies for music has also gained momentum. Given the recognition of covert muscular activity as a strong indicator of musical intentionality and the previously ascertained link between physical effort and various musical aspects, electromyography (EMG)—signals representing muscle activity—has also experienced a noticeable surge. While EMG technologies appear to hold good promise for sensing, capturing, and interpreting the dynamic properties of movement in music, which are considered innately linked to artistic expressive power, they also come with certain challenges, misconceptions, and predispositions. The paper engages in a critical examination regarding the utilisation of muscle force values from EMG sensors as indicators of physical effort and musical activity, particularly focusing on (the intuitively expected link to) sound levels. For this, it resides upon empirical work, namely practical insights drawn from a case study of music performance (Persian instrumental music) in the context of a music class. The findings indicate that muscle force can be explained by a small set of (six) statistically significant acoustic and movement features, the latter captured by a state-of-the-art (full-body inertial) motion capture system. However, no straightforward link to sound levels is evident. Full article
(This article belongs to the Special Issue Multimodal Interaction in Education)
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13 pages, 3191 KiB  
Article
Efficient Separation of Re (VII) and Mo (VI) by Extraction Using E-1006–Ammonium Sulfate Aqueous Two-Phase System
by Linlin Fan, Wenhui Li, Zilong Dai, Min Zhou and Yunren Qiu
Separations 2024, 11(5), 142; https://doi.org/10.3390/separations11050142 (registering DOI) - 07 May 2024
Abstract
Aqueous two-phase extraction (APTE) stands out as an environmentally friendly technique for the separation of metal ions. The separation of Re (VII) and Mo (VI) in an aqueous solution was investigated using a novel aqueous two-phase system (ATPS) consisting of isodecanol polyoxyethylene ether [...] Read more.
Aqueous two-phase extraction (APTE) stands out as an environmentally friendly technique for the separation of metal ions. The separation of Re (VII) and Mo (VI) in an aqueous solution was investigated using a novel aqueous two-phase system (ATPS) consisting of isodecanol polyoxyethylene ether (E-1006), ammonium sulfate, and water. A phase diagram of this system was developed, and the effects of pH, temperature, extraction time, the concentrations of E-1006 and (NH4)2SO4, and metal ions on the separation of Re (VII) and Mo (VI) were examined. The results show that at pH 7.0, Mo (VI) had almost transformed into the (NH4)2SO4-rich phase, while Re (VI) was extracted into the E-1006-rich phase. The increase in temperature induces a transition of Mo (VI) to the salt-rich phase, which is unfavorable for the extraction of Re (VII). The increase in the concentrations of E-1006 and (NH4)2SO4 has a positive effect on the separation of rhenium and molybdenum. Overall, the ATPS consisting of 200 g/L of E-1006, 200 g/L of (NH4)2SO4, and water yields an extraction efficiency of 97.2% for Re and a high separation factor of 2700 for Re (VII) and Mo (VI) from a mixture of 0.1 g/L of Re (VII) and 5 g/L of Mo (VI) at pH 7.0 and 323.15 K. Separation studies of the simulated leaching solution show that the extraction efficiency for Re (VI) is 99.1% and the separation factor of Re (VII) and Mo (VI) is 5100. Full article
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