The 2023 MDPI Annual Report has
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20 pages, 799 KiB  
Article
Developing a Measurement Framework for Ethiopian Dry Port Sustainability: An Empirical Study
by Zellalem Tadesse Beyene, Simon Peter Nadeem and Matiwos Ensermu Jaleta
Sustainability 2024, 16(9), 3878; https://doi.org/10.3390/su16093878 (registering DOI) - 06 May 2024
Abstract
In the context of a dry port, sustainable operations involve developing and implementing policies and procedures that reduce adverse effects on the environment, advance economic viability, and strengthen social responsibility. Several factors contribute to achieving environmental, economic, and social sustainability, making it critical [...] Read more.
In the context of a dry port, sustainable operations involve developing and implementing policies and procedures that reduce adverse effects on the environment, advance economic viability, and strengthen social responsibility. Several factors contribute to achieving environmental, economic, and social sustainability, making it critical to identify the factors influencing the sustainability of dry port operations. This research aims to identify decisive factors associated with economic, social, and environmental sustainability, and to develop a framework for measuring sustainability in dry port operations. The research utilises exploratory factor analysis (EFA) and the analytical hierarchical process (AHP) to develop a measurement framework for assessing the sustainability of Ethiopian dry ports. EFA is an effective method with which to identify factors that contribute to sustainable dry port operations. To provide a frame for the critical sustainability performance metrics for dry ports, the AHP approach was used. Data were collected from 300 stakeholders using surveys to identify key factors, and 20 senior experts were involved in validating and rating the most influential factors determining dry port sustainability. This research asserts the most pertinent factors guiding dry port sustainability operations, resource allocation, and decision-making. From an environmental sustainability perspective, critical factors include minimising business-partner impacts, reducing waste, addressing climate change, providing environmental planning education to teams, and implementing measures to protect the national environment. From a social perspective, the factors identified include a resettlement policy, employment opportunities for the community, workplace safety, stakeholder consultation, and top-management guidance. From an economic standpoint, critical factors include value-added services, reduced transportation costs, decreased time, enhanced productivity in the trade supply chain, and profit orientation. The research provides valuable insights with which to guide the development of practices and policies aimed at ensuring sustainable dry port operations, a critical domain of the trade supply chain. Full article
(This article belongs to the Section Economic and Business Aspects of Sustainability)
16 pages, 4416 KiB  
Article
A Comparative Study of Cerium(III) and Cerium(IV) Phosphates for Sunscreens
by Taisiya O. Kozlova, Darya N. Vasilyeva, Daniil A. Kozlov, Irina V. Kolesnik, Maria A. Teplonogova, Ilya V. Tronev, Ekaterina D. Sheichenko, Maria R. Protsenko, Danil D. Kolmanovich, Olga S. Ivanova, Alexander E. Baranchikov and Vladimir K. Ivanov
Molecules 2024, 29(9), 2157; https://doi.org/10.3390/molecules29092157 (registering DOI) - 06 May 2024
Abstract
Crystalline cerium(III) phosphate (CePO4), cerium(IV) phosphates, and nanocrystalline ceria are considered to be promising components of sunscreen cosmetics. This paper reports on a study in which, for the first time, a quantitative comparative analysis was performed of the UV-shielding properties of [...] Read more.
Crystalline cerium(III) phosphate (CePO4), cerium(IV) phosphates, and nanocrystalline ceria are considered to be promising components of sunscreen cosmetics. This paper reports on a study in which, for the first time, a quantitative comparative analysis was performed of the UV-shielding properties of CePO4, Ce(PO4)(HPO4)0.5(H2O)0.5, and CePO4/CeO2 composites. Both the sun protection factor and protection factor against UV-A radiation of the materials were determined. Ce(PO4)(HPO4)0.5(H2O)0.5 was shown to have a sun protection factor of 2.9, which is comparable with that of nanocrystalline ceria and three times higher than the sun protection factor of CePO4. Composites containing both cerium dioxide and CePO4 demonstrated higher sun protection factors (up to 1.8) than individual CePO4. When compared with the TiO2 Aeroxide P25 reference sample, cerium(III) and cerium(IV) phosphates demonstrated negligible photocatalytic activity. A cytotoxicity analysis performed using two mammalian cell lines, hMSc and NCTC L929, showed that CePO4, Ce(PO4)(HPO4)0.5(H2O)0.5, and nanocrystalline ceria were all non-toxic. The results of this comparative study indicate that cerium(IV) phosphate Ce(PO4)(HPO4)0.5(H2O)0.5 is more advantageous for use in sunscreens than either cerium(III) phosphate or CePO4/CeO2 composites, due to its improved UV-shielding properties and low photocatalytic activity. Full article
(This article belongs to the Section Applied Chemistry)
18 pages, 9458 KiB  
Article
Collaborative Methods of Resolving Road Graphic Conflicts Based on Cartographic Rules and Generalization Operations
by Chuanbang Zheng, Qingsheng Guo, Lin Wang, Yuangang Liu and Jianfeng Jiang
ISPRS Int. J. Geo-Inf. 2024, 13(5), 154; https://doi.org/10.3390/ijgi13050154 (registering DOI) - 06 May 2024
Abstract
The resolution of road graphic conflicts is a key aspect of map generalization, which involves both scale reduction and the symbolization of map features. This study proposes collaborative methods of road graphic conflict resolution considering different road characteristics. These methods consider both geometric [...] Read more.
The resolution of road graphic conflicts is a key aspect of map generalization, which involves both scale reduction and the symbolization of map features. This study proposes collaborative methods of road graphic conflict resolution considering different road characteristics. These methods consider both geometric and semantic characteristics, and they incorporate the bend characteristics of roads, the road symbol size, and road semantics. Constrained Delaunay triangulation skeleton lines are used to categorize road graphic conflicts, which are made up of four independent conflict types and four group conflict types. Based on their characteristics, three collaborative methods are designed to deal with the different types of road graphic conflicts: collaboration between deletion and the snake displacement model, collaboration between the snake displacement model and collinearity, and collaboration among simplification, smoothing, and the beam displacement model. Two types of independent conflicts can be processed using only one simple operation. This study summarizes the cartographic rules for resolving road graphic conflicts, and these are used along with geometric features to drive the collaborative methods or one simple operation presented here. The experimental results indicate that the method proposed in this study can effectively resolve road graphic conflicts. Full article
15 pages, 1012 KiB  
Review
Structure, Regulation, and Significance of Cyanobacterial and Chloroplast Adenosine Triphosphate Synthase in the Adaptability of Oxygenic Photosynthetic Organisms
by Siyan Yi, Xin Guo, Wenjing Lou, Shaoming Mao, Guodong Luan and Xuefeng Lu
Microorganisms 2024, 12(5), 940; https://doi.org/10.3390/microorganisms12050940 (registering DOI) - 06 May 2024
Abstract
In cyanobacteria and chloroplasts (in algae and plants), ATP synthase plays a pivotal role as a photosynthetic membrane complex responsible for producing ATP from adenosine diphosphate and inorganic phosphate, utilizing a proton motive force gradient induced by photosynthesis. These two ATP synthases exhibit [...] Read more.
In cyanobacteria and chloroplasts (in algae and plants), ATP synthase plays a pivotal role as a photosynthetic membrane complex responsible for producing ATP from adenosine diphosphate and inorganic phosphate, utilizing a proton motive force gradient induced by photosynthesis. These two ATP synthases exhibit similarities in gene organization, amino acid sequences of subunits, structure, and functional mechanisms, suggesting that cyanobacterial ATP synthase is probably the evolutionary precursor to chloroplast ATP synthase. In this review, we explore the precise synthesis and assembly of ATP synthase subunits to address the uneven stoichiometry within the complex during transcription, translation, and assembly processes. We also compare the regulatory strategies governing ATP synthase activity to meet varying energy demands in cyanobacteria and chloroplasts amid fluctuating natural environments. Furthermore, we delve into the role of ATP synthase in stress tolerance and photosynthetic carbon fixation efficiency in oxygenic photosynthetic organisms (OPsOs), along with the current researches on modifying ATP synthase to enhance carbon fixation efficiency under stress conditions. This review aims to offer theoretical insights and serve as a reference for understanding the functional mechanisms of ATP synthase, sparking innovative ideas for enhancing photosynthetic carbon fixation efficiency by utilizing ATP synthase as an effective module in OPsOs. Full article
(This article belongs to the Section Environmental Microbiology)
10 pages, 5876 KiB  
Communication
Benthic Biodiversity by Baited Camera Observations on the Cosmonaut Sea Shelf of East Antarctica
by Jianfeng Mou, Xuebao He, Kun Liu, Yaqin Huang, Shuyi Zhang, Yongcan Zu, Yanan Liu, Shunan Cao, Musheng Lan, Xing Miao, Heshan Lin and Wenhua Liu
Diversity 2024, 16(5), 277; https://doi.org/10.3390/d16050277 (registering DOI) - 06 May 2024
Abstract
A free-fall baited camera lander was launched for the first time on the Cosmonaut Sea shelf of East Antarctica at a depth of 694 m during the 38th Chinese National Antarctic Research Expedition (CHINARE) in 2022. We identified 31 unique taxa (23 were [...] Read more.
A free-fall baited camera lander was launched for the first time on the Cosmonaut Sea shelf of East Antarctica at a depth of 694 m during the 38th Chinese National Antarctic Research Expedition (CHINARE) in 2022. We identified 31 unique taxa (23 were invertebrates and eight were fish) belonging to eight phyla from 2403 pictures and 40 videos. The Antarctic jonasfish (Notolepis coatsi) was the most frequently observed fish taxa. Ten species of vulnerable marine ecosystem (VME) taxa were observed, accounting for 32% of all species. The maximum number (MaxN) of Natatolana meridionalis individuals per image frame was ten, and they were attracted to the bait. The macrobenthic community type were sessile suspension feeders with associated fauna (SSFA), which was shaped by the muddy substrata with scattered rocks. Rocks served as the best habitats for sessile fauna. The study reveals the megafauna community and their habitat by image survey in the Cosmonaut Sea for the first time. It helped us obtain Antarctic biodiversity baselines and monitoring data for future ecosystem health assessment and better protection. Full article
(This article belongs to the Special Issue Ecology and Biogeography of Marine Benthos)
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16 pages, 1431 KiB  
Review
Use of Digital Tools for the Assessment of Food Consumption in Brazil: A Scoping Review
by Adriane dos Santos da Silva, Flávia dos Santos Barbosa Brito, Debora Martins dos Santos and Amanda Rodrigues Amorim Adegboye
Nutrients 2024, 16(9), 1399; https://doi.org/10.3390/nu16091399 (registering DOI) - 06 May 2024
Abstract
This is a scoping review on mapping the use of digital tools to assess food consumption in Brazil. Searches were carried out in nine electronic databases (Medline, Lilacs, Scopus, Embase, Web of Science, Science Direct, Ovid, Free Medical Journal and Crossref) to select [...] Read more.
This is a scoping review on mapping the use of digital tools to assess food consumption in Brazil. Searches were carried out in nine electronic databases (Medline, Lilacs, Scopus, Embase, Web of Science, Science Direct, Ovid, Free Medical Journal and Crossref) to select studies published from October 2020 to December 2023. This review identified forty-eight digital tools in the 94 publications analyzed, the most frequent being web-based technologies (60%) and mobile devices (40%). Among these studies, 55% (n = 52) adopted a population-based approach, while 45% (n = 42) focused on specific regions. The predominant study design observed was cross-sectional (n = 63). A notable trend observed was the increasing frequency of validation studies in recent years. Although the use of digital tools in the assessment of food consumption in Brazil has grown in recent years, studies did not describe the process of creating and validating the tools, which would contribute to the improvement of data quality. Investments that allow the expansion of the use of the internet and mobile devices; the improvement of digital literacy; and the development of open-access tools, especially in the North and Northeast regions, are challenges that require a concerted effort towards providing equal opportunities, fostering encouragement, and delving deeper into the potential of digital tools within studies pertaining to food consumption in Brazil. Full article
(This article belongs to the Special Issue Digital Transformations in Nutrition)
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16 pages, 663 KiB  
Article
Influences of a Supplemental Blend of Essential Oils plus 25-Hydroxy-Vit-D3 and Zilpaterol Hydrochloride (β2 Agonist) on Growth Performance and Carcass Measures of Feedlot Lambs Finished under Conditions of High Ambient Temperature
by Alfredo Estrada-Angulo, Moisés Verdugo-Insúa, Lucía de G. Escobedo-Gallegos, Beatriz I. Castro-Pérez, Jesús D. Urías-Estrada, Elizama Ponce-Barraza, Daniel Mendoza-Cortez, Francisco G. Ríos-Rincón, Francisco Monge-Navarro, Alberto Barreras, Richard A. Zinn, Luis Corona-Gochi and Alejandro Plascencia
Animals 2024, 14(9), 1391; https://doi.org/10.3390/ani14091391 (registering DOI) - 06 May 2024
Abstract
Forty-eight Pelibuey × Katahdin male intact lambs (25.12 ± 3.79 kg LW) were used in a 70-d growing-finishing trial. Dietary treatments consisted of total mixed corn-based diet supplemented with: (1) no feed additives (Control); (2) 150 mg of essential oils blend plus 0.10 [...] Read more.
Forty-eight Pelibuey × Katahdin male intact lambs (25.12 ± 3.79 kg LW) were used in a 70-d growing-finishing trial. Dietary treatments consisted of total mixed corn-based diet supplemented with: (1) no feed additives (Control); (2) 150 mg of essential oils blend plus 0.10 mg of 25-hydroxy-Vit-D3/kg diet offered throughout the 70-d experimental period (EOD3); (3) Control diet fed during the first 35 days and zilpaterol hydrochloride (ZH) supplementation at 6 mg/kg diet offered during the final 35 days of the experiment (32 days with ZH with a withdrawal 3-d before harvest), and (4) basal diet supplemented with EOD3 during first 35 days finishing, and EOD3 in combination with ZH (EOD3 + ZH) during the subsequent 32-days with ZH withdrawal 3 days before harvest. The temperature–humidity index during the experiment averaged 80.4 ± 3.2. There were no treatment interactions (p > 0.20) on growth performance and carcass measures. Supplemental EOD3 did not affect (p = 0.43) dry matter intake (DMI), but increased (p < 0.01) carcass adjusted average daily gain (ADG, 9.2%), gain efficiency (GF, 6.7%), and observed vs. expected dietary net energy for maintenance (NEm, 4.8%) and for gain (NEg, 6.4%). Supplemental ZH did not affect dry matter intake (DMI, p = 0.50) but increased (p < 0.01) carcass adjusted ADG (14.5%), GF (13%) and observed vs. expected dietary NEm (9%) and NEg (11.7%). Compared to control lambs, the combination of both additives increased ADG (24.9%), GF (21.2%), and observed vs. expected dietary NEm and NEg (14.2% and 18.9%, respectively). There were no treatment interactions on carcass characteristics, visceral organ mass, or on gene expression of IGF1, IGF2 and mTOR in longissimus muscle (LM). Supplemental EOD3 increased hot carcass weight (HCW; 4.0%, p < 0.01) but did not affect other carcass measures. Supplemental EOD3 decreased (3%, p = 0.03) intestine mass weight (g intestine/kg empty body weight). Supplemental ZH increased HCW (6%, p < 0.01), dressing percentage (1.7%, p = 0.04), and LM area (9.7%, p < 0.01), and decreased kidney-pelvic-fat percentage (16.2%, p < 0.01), fat thickness (14.7%, p = 0.03), and visceral fat. Compared to controls, the combination of EOD3 with ZH increased HCW (10.2%). It is concluded that growth performance responses to supplemental EOD3 and ZH are additive. Both supplements can be fed in combination without detrimental effects on expected benefits when fed separately. In addition, ZH supplementation improves carcass traits. Full article
(This article belongs to the Special Issue Feed Additives, Performance and Welfare in Domestic Animals)
11 pages, 969 KiB  
Article
A W-Band Chebyshev Waveguide Bandpass Filter with Wide Stopband Performance
by Zhongbo Zhu, Weidong Hu, Kaida Xu, Yuming Bai and Sheng Li
Electronics 2024, 13(9), 1793; https://doi.org/10.3390/electronics13091793 (registering DOI) - 06 May 2024
Abstract
In this paper, a W-band waveguide bandpass filter with a standard fourth-order Chebyshev response is proposed based on the computer numerical control (CNC)-milling technology. The harmonics-staggered technique and orthogonal coupling method are incorporated into this waveguide filter design without increasing the complexity [...] Read more.
In this paper, a W-band waveguide bandpass filter with a standard fourth-order Chebyshev response is proposed based on the computer numerical control (CNC)-milling technology. The harmonics-staggered technique and orthogonal coupling method are incorporated into this waveguide filter design without increasing the complexity of the filter structure in order to suppress the intrinsic spurious responses near the passband. Furthermore, the proposed filter design maintains a simple construction, which can be conveniently fabricated using CNC milling. The fabricated waveguide filter exhibits an average insertion loss of 0.9 dB and a return loss of above 20 dB in a 3 dB fractional bandwidth (FBW) of 5.5% centered at 85 GHz. The excellent spurious suppression property can reach better than −25 dB up to 165 GHz. The wide stopband performance of the proposed W-band filter is very competitive compared with the reported waveguide filters. Full article
(This article belongs to the Special Issue Feature Papers in Microwave and Wireless Communications Section)
14 pages, 1438 KiB  
Article
Metabolome in Tibialis and Soleus Muscles in Wild-Type and Pin1 Knockout Mice through High-Resolution Magic Angle Spinning 1H Nuclear Magnetic Resonance Spectroscopy
by Valeria Righi, Martina Grosso, Renata Battini, Takafumi Uchida, Anna Gambini, Susanna Molinari and Adele Mucci
Metabolites 2024, 14(5), 262; https://doi.org/10.3390/metabo14050262 (registering DOI) - 06 May 2024
Abstract
Skeletal muscles are heterogenous tissues composed of different myofiber types that can be classified as slow oxidative, fast oxidative, and fast glycolytic which are distinguished on the basis of their contractile and metabolic properties. Improving oxidative metabolism in skeletal muscles can prevent metabolic [...] Read more.
Skeletal muscles are heterogenous tissues composed of different myofiber types that can be classified as slow oxidative, fast oxidative, and fast glycolytic which are distinguished on the basis of their contractile and metabolic properties. Improving oxidative metabolism in skeletal muscles can prevent metabolic diseases and plays a protective role against muscle wasting in a number of neuromuscular diseases. Therefore, achieving a detailed understanding of the factors that regulate myofiber metabolic properties might provide new therapeutic opportunities for these diseases. Here, we investigated whether peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) is involved in the control of myofiber metabolic behaviors. Indeed, PIN1 controls glucose and lipid metabolism in a number of tissues, and it is also abundant in adult skeletal muscles; however, its role in the control of energy homeostasis in this tissue is still to be defined. To start clarifying this topic, we compared the metabolome of the tibialis anterior muscle (mainly glycolytic) and soleus muscle (oxidative) in wild-type and Pin1 knockout mice with High-Resolution Magic Angle Spinning (HR-MAS) NMR on intact tissues. Our analysis reveals a clear demarcation between the metabolomes in the two types of muscles and allows us to decode a signature able to discriminate the glycolytic versus oxidative muscle phenotype. We also detected some changes in Pin1-depleted muscles that suggest a role for PIN1 in regulating the metabolic phenotype of skeletal muscles. Full article
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20 pages, 5077 KiB  
Article
Sliding Mode Flight Control Law Design Requirements for Oblique Wing Aircraft Based on Perturbation Theory
by Lixin Wang, Xun Sun, Hailiang Liu, Jingzhong Ma, Wenyuan Cheng, Shang Tai, Yun Zhu and Ting Yue
Aerospace 2024, 11(5), 366; https://doi.org/10.3390/aerospace11050366 (registering DOI) - 06 May 2024
Abstract
Flight control law parameters should be designed to provide a sufficient stability margin for closed-loop aircraft while ensuring command tracking accuracy. The singular perturbation margin (SPM) and generalized gain margin (GGM), which are generalizations of the classical phase margin (PM) and gain margin [...] Read more.
Flight control law parameters should be designed to provide a sufficient stability margin for closed-loop aircraft while ensuring command tracking accuracy. The singular perturbation margin (SPM) and generalized gain margin (GGM), which are generalizations of the classical phase margin (PM) and gain margin (GM), respectively, from a linear time-invariant system to a nonlinear time-varying system, can be used to quantitatively characterize the maximum singular perturbation and regular perturbation allowed to maintain system stability. In this paper, the sliding mode flight control structure and the design parameters of the sliding mode control law are first introduced for an oblique wing aircraft (OWA), the SPM-gauge and GGM-gauge are added to this closed-loop aircraft model, and the analytical expressions of the SPM and GGM are derived with respect to the control law parameters. Second, the stability margin design requirements of closed-loop aircraft in flight control system design specifications are converted into limitations on the SPM and GGM to determine the value range of the flight control law parameters. Then, with the goal of reducing the sum of the approaching time and sliding time, the parameter value combination is selected within the control law parameter range that meets the stability margin requirements, thus forming a flight control law design method for OWA during the wing skewing process. Finally, the designed control law parameters are applied to a sample OWA, and the stability margin of closed-loop aircraft during the wing skewing process is verified. Full article
(This article belongs to the Special Issue Flight Control (2nd Edition))
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21 pages, 26614 KiB  
Article
Effect of the 35 nm and 70 nm Size Exclusion Chromatography (SEC) Column and Plasma Storage Time on Separated Extracellular Vesicles
by Bernadett György, Krisztina Pálóczi, Mirjam Balbisi, Lilla Turiák, László Drahos, Tamás Visnovitz, Erika Koltai and Zsolt Radák
Curr. Issues Mol. Biol. 2024, 46(5), 4337-4357; https://doi.org/10.3390/cimb46050264 (registering DOI) - 06 May 2024
Abstract
The technical difficulty of separating extracellular vesicles (EVs) from plasma proteins in human blood presents a significant hurdle in EV research, particularly during nano ultra-high-performance liquid chromatography–tandem mass spectrometric (UHPLC-MS/MS) analysis, where detecting “vesicular” proteins among abundant plasma proteins is challenging. Standardisation is [...] Read more.
The technical difficulty of separating extracellular vesicles (EVs) from plasma proteins in human blood presents a significant hurdle in EV research, particularly during nano ultra-high-performance liquid chromatography–tandem mass spectrometric (UHPLC-MS/MS) analysis, where detecting “vesicular” proteins among abundant plasma proteins is challenging. Standardisation is a pressing issue in EV research, prompting collaborative global efforts to address it. While the MISEV guidelines offer valuable recommendations, unanswered questions remain, particularly regarding sample storage. We compared size exclusion chromatography (SEC) columns with pore sizes of 35 nm and 70 nm to identify fractions with minimal contaminating proteins and the highest concentration of small EVs (sEVs). Following column selection, we explored potential differences in the quality and quantity of sEVs isolated from platelet-free plasma (PFP) after long-term storage at −80 °C (>2.5 years) compared to freshly drawn blood. Our methodologically rigorous study indicates that prolonged storage, under correct storage and processing conditions, does not compromise sEV quality. Both columns effectively isolated vesicles, with the 70 nm column exhibiting a higher abundance of “vesicular” proteins. We propose a relatively rapid and moderately efficient protocol for obtaining a comparatively pure sEV fraction from plasma, facilitating sEV processing in clinical trials. Full article
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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14 pages, 3166 KiB  
Article
Prognostic Value of B7H4 Expression in Patients with Solid Cancers: A Systematic Review and Meta-Analysis
by Miriam Dawidowicz, Agnieszka Kula, Sylwia Mielcarska, Elżbieta Świętochowska and Dariusz Waniczek
Int. J. Mol. Sci. 2024, 25(9), 5045; https://doi.org/10.3390/ijms25095045 (registering DOI) - 06 May 2024
Abstract
V-set domain-containing T-cell activation inhibitor 1 (aliases VTCN1, B7H4) participates in tumour immune escape by delivering inhibitory signals to T cells. The purpose of this article was to assess the B7H4 prognostic value in solid cancers. Three databases were searched for relevant articles. [...] Read more.
V-set domain-containing T-cell activation inhibitor 1 (aliases VTCN1, B7H4) participates in tumour immune escape by delivering inhibitory signals to T cells. The purpose of this article was to assess the B7H4 prognostic value in solid cancers. Three databases were searched for relevant articles. The main endpoints were overall survival (OS), disease-specific survival (DSS), progression-free survival (PFS), recurrence-free survival (RFS), and disease-free survival (DFS). Appropriate hazard ratios (HRs) were pooled. The R studio software (version 4.0.3) was used for data analysis. Thirty-one studies met the inclusion criteria. High expression of B7H4 was associated with worse OS (HR = 1.52, 95% CI: 1.37–1.68) but not with DSS (HR = 1.14, 95% CI: 0.49–2.63), RFS (HR = 1.77, 95% CI: 0.75–4.18), DFS (HR = 1.29, 95% CI: 0.8–2.09), or PFS (HR = 1.71, 95% CI: 0.91–3.2) in patients with solid cancers. High expression of B7H4 is associated with a poorer prognosis in patients with solid cancers. B7H4 is a promising prognostic biomarker and immunotherapeutic target for various solid cancers because of its activity in cancer immunity and tumourigenesis. Full article
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26 pages, 10114 KiB  
Review
Waste Glass Upcycling Supported by Alkali Activation: An Overview
by Muhammad Jamshaid Zafar, Hamada Elsayed and Enrico Bernardo
Materials 2024, 17(9), 2169; https://doi.org/10.3390/ma17092169 (registering DOI) - 06 May 2024
Abstract
Alkali-activated materials are gaining much interest due to their outstanding performance, including their great resistance to chemical corrosion, good thermal characteristics, and ability to valorise industrial waste materials. Reusing waste glasses in creating alkali-activated materials appears to be a viable option for more [...] Read more.
Alkali-activated materials are gaining much interest due to their outstanding performance, including their great resistance to chemical corrosion, good thermal characteristics, and ability to valorise industrial waste materials. Reusing waste glasses in creating alkali-activated materials appears to be a viable option for more effective solid waste utilisation and lower-cost products. However, very little research has been conducted on the suitability of waste glass as a prime precursor for alkali activation. This study examines the reuse of seven different types of waste glasses in the creation of geopolymeric and cementitious concretes as sustainable building materials, focusing in particular on how using waste glasses as the raw material in alkali-activated materials affects the durability, microstructures, hydration products, and fresh and hardened properties in comparison with using traditional raw materials. The impacts of several vital parameters, including the employment of a chemical activator, gel formation, post-fabrication curing procedures, and the distribution of source materials, are carefully considered. This review will offer insight into an in-depth understanding of the manufacturing and performance in promising applications of alkali-activated waste glass in light of future uses. The current study aims to provide a contemporary review of the chemical and structural properties of glasses and the state of research on the utilisation of waste glasses in the creation of alkali-activated materials. Full article
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20 pages, 4271 KiB  
Article
The Efficiency of YOLOv5 Models in the Detection of Similar Construction Details
by Tautvydas Kvietkauskas, Ernest Pavlov, Pavel Stefanovič and Birutė Pliuskuvienė
Appl. Sci. 2024, 14(9), 3946; https://doi.org/10.3390/app14093946 (registering DOI) - 06 May 2024
Abstract
Computer vision solutions have become widely used in various industries and as part of daily solutions. One task of computer vision is object detection. With the development of object detection algorithms and the growing number of various kinds of image data, different problems [...] Read more.
Computer vision solutions have become widely used in various industries and as part of daily solutions. One task of computer vision is object detection. With the development of object detection algorithms and the growing number of various kinds of image data, different problems arise in relation to the building of models suitable for various solutions. This paper investigates the influence of parameters used in the training process involved in detecting similar kinds of objects, i.e., the hyperparameters of the algorithm and the training parameters. This experimental investigation focuses on the widely used YOLOv5 algorithm and analyses the performance of different models of YOLOv5 (n, s, m, l, x). In the research, the newly collected construction details (22 categories) dataset is used. Experiments are performed using pre-trained models of the YOLOv5. A total of 185 YOLOv5 models are trained and evaluated. All models are tested on 3300 images photographed on three different backgrounds: mixed, neutral, and white. Additionally, the best-obtained models are evaluated using 150 new images, each of which has several dozen construction details and is photographed against different backgrounds. The deep analysis of different YOLOv5 models and the hyperparameters shows the influence of various parameters when analysing the object detection of similar objects. The best model was obtained when the YOLOv5l was used and the parameters are as follows: coloured images, image size—320; batch size—32; epoch number—300; layers freeze option—10; data augmentation—on; learning rate—0.001; momentum—0.95; and weight decay—0.0007. These results may be useful for various tasks in which small and similar objects are analysed. Full article
(This article belongs to the Special Issue Computer Vision in Automatic Detection and Identification)
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9 pages, 1151 KiB  
Article
Chaos Synchronization of Integrated Five-Section Semiconductor Lasers
by Yuanyuan Guo, Yao Du, Hua Gao, Min Tan, Tong Zhao, Zhiwei Jia, Pengfa Chang and Longsheng Wang
Entropy 2024, 26(5), 405; https://doi.org/10.3390/e26050405 (registering DOI) - 06 May 2024
Abstract
We proposed and verified a scheme of chaos synchronization for integrated five-section semiconductor lasers with matching parameters. The simulation results demonstrated that the integrated five-section semiconductor laser could generate a chaotic signal within a large parameter range of the driving currents of five [...] Read more.
We proposed and verified a scheme of chaos synchronization for integrated five-section semiconductor lasers with matching parameters. The simulation results demonstrated that the integrated five-section semiconductor laser could generate a chaotic signal within a large parameter range of the driving currents of five sections. Subsequently, chaos synchronization between two integrated five-section semiconductor lasers with matched parameters was realized by using a common noise signal as a driver. Moreover, it was found that the synchronization was sensitive to the current mismatch in all five sections, indicating that the driving currents of the five sections could be used as keys of chaotic optical communication. Therefore, this synchronization scheme provides a candidate to increase the dimension of key space and enhances the security of the system. Full article
13 pages, 840 KiB  
Article
Dose Escalation Can Enhance the Therapeutic Potential of Radial Extracorporeal Shock-Wave Therapy in the Treatment of Plantar Fasciitis in Runners
by Sebastian Szajkowski, Jarosław Pasek and Grzegorz Cieślar
Medicina 2024, 60(5), 766; https://doi.org/10.3390/medicina60050766 (registering DOI) - 06 May 2024
Abstract
Background and Objectives: Treatment of chronic plantar fasciitis is challenging given that there are various of available treatment options with no clear gold standard. The aim of the study was to examine the dose-escalation effect of rESWT on the biomechanical parameters of the [...] Read more.
Background and Objectives: Treatment of chronic plantar fasciitis is challenging given that there are various of available treatment options with no clear gold standard. The aim of the study was to examine the dose-escalation effect of rESWT on the biomechanical parameters of the plantar fascia and pain ailments. Materials and Methods: In the experimental group (n = 30), the intensity of the shock wave was increased every two subsequent treatment sessions. In the control group (n = 32), the treatment parameters were not changed. In both groups, six treatments were performed, with two treatment sessions a week. In order to assess the biomechanical parameters of the plantar fascia, myotonometric measurements were performed. The pain intensity was assessed using the Visual Analog Scale (VAS). Results: The tension of the plantar fascia attachment in the experimental group decreased from 27.69 ± 2.06 [Hz] before treatment to 26.29 ± 1.69 [Hz] after treatment (p = 0.009) and to 26.03 ± 2.15 [Hz] 1 month after the beginning of treatment (p = 0.003). In the control group, the frequency results did not change significantly (p > 0.05). Flexibility increased in both groups. The test results before treatment and 1 month after the beginning of the treatment showed statistical significance in the experimental group (p = 0.001) vs. (p = 0.002) in the control group. The differences were not statistically significant between groups (p > 0.05). The assessment of pain intensity carried out 1 month after the end of treatment in the experimental group amounted to 3.14 ± 2.28 points, which was statistically significantly lower compared to that in the control group, where it amounted to 5.14 ± 1.92 points. (p < 0.001). Conclusions: The use of rESWT performed with an increasing intensity of impact during subsequent treatment procedures demonstrated greater effectiveness in improving the biomechanical parameters of the plantar fascia and was also more effective in reducing the pain ailments. Our results are encouraging. The dose escalation in the treatment cycle is worth considering. To prove that this method of treatment is more effective, a randomized controlled trial should be carried out on a representative sample. Full article
(This article belongs to the Section Sports Medicine and Sports Traumatology)
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26 pages, 929 KiB  
Systematic Review
Effect of Sustainably Sourced Protein Consumption on Nutrient Intake and Gut Health in Older Adults: A Systematic Review
by Debra Jones, Carlos Celis-Morales, Stuart R. Gray, Douglas J. Morrison, Susan E. Ozanne, Mahek Jain, Lewis R. Mattin and Sorrel Burden
Nutrients 2024, 16(9), 1398; https://doi.org/10.3390/nu16091398 (registering DOI) - 06 May 2024
Abstract
Diet is integral to the healthy ageing process and certain diets can mitigate prolonged and deleterious inflammation. This review aims to assess the impact of diets high in sustainably sourced proteins on nutrient intake, gut, and age-related health in older adults. A systematic [...] Read more.
Diet is integral to the healthy ageing process and certain diets can mitigate prolonged and deleterious inflammation. This review aims to assess the impact of diets high in sustainably sourced proteins on nutrient intake, gut, and age-related health in older adults. A systematic search of the literature was conducted on 5 September 2023 across multiple databases and sources. Studies assessing sustainably sourced protein consumption in community dwelling older adults (≥65 years) were included. Risk of bias (RoB) was assessed using ‘RoB 2.0′ and ‘ROBINS-E’. Narrative synthesis was performed due to heterogeneity of studies. Twelve studies involving 12,166 older adults were included. Nine studies (n = 10,391) assessed habitual dietary intake and had some RoB concerns, whilst three studies (n = 1812), two with low and one with high RoB, conducted plant-based dietary interventions. Increased adherence to sustainably sourced diets was associated with improved gut microbial factors (n = 4640), healthier food group intake (n = 2142), and increased fibre and vegetable protein intake (n = 1078). Sustainably sourced diets positively impacted on gut microbiota and healthier intake of food groups, although effects on inflammatory outcomes and health status were inconclusive. Future research should focus on dietary interventions combining sustainable proteins and fibre to evaluate gut barrier function and consider inflammatory and body composition outcomes in older adults. Full article
(This article belongs to the Section Geriatric Nutrition)
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10 pages, 1156 KiB  
Technical Note
The Effect of Temperature on the Inflorescence Formation Model for Phalaenopsis
by Jiunyuan Chen and Chiachung Chen
Plants 2024, 13(9), 1280; https://doi.org/10.3390/plants13091280 (registering DOI) - 06 May 2024
Abstract
Phalaenopsis orchids are a popular ornamental plant in the flower market. During some festivals, demand increases significantly. These mature orchids must be placed in cooling rooms for inflorescence formation at specific times to increase the financial return from their sale. The purpose of [...] Read more.
Phalaenopsis orchids are a popular ornamental plant in the flower market. During some festivals, demand increases significantly. These mature orchids must be placed in cooling rooms for inflorescence formation at specific times to increase the financial return from their sale. The purpose of this study is to evaluate the effect of day and night temperatures on the inflorescence formation percentage using the proposed sigmoid model. Four varieties that are cultured in different vegetative temperature regimes are placed in a cooling room. An empirical inflorescence formation model is proposed as a management tool to predict the inflorescence formation percentage for Phalaenopsis. Some data sets from previous studies are used for comparison. The accumulation temperature is calculated using the day and night temperatures and is an index to predict the inflorescence formation percentage. The results show that there is a similar distribution of the inflorescence formation percentage and accumulation temperature for the four varieties. The proposed sigmoid model has a good fitting ability for the inflorescence formation percentage. This inflorescence formation model from the pooled data sets allows quantitative microclimate management of the vegetative and cooling room. Full article
(This article belongs to the Special Issue Modelling for Prediction of Horticultural Plant Growth and Defense)
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20 pages, 2308 KiB  
Article
Water Banking as a Strategy for the Management and Conservation of a Critical Resource: A Case Study from Tunisia’s Medjerda River Basin (MRB)
by Aymen Sawassi, Roula Khadra and Brian Crookston
Sustainability 2024, 16(9), 3875; https://doi.org/10.3390/su16093875 (registering DOI) - 06 May 2024
Abstract
The increasingly adverse impacts of climate change (e.g., rainfall patterns, droughts, and floods), coupled with the ever-increasing water demands, are often translated into a contingent liability for water users’ communities. Additional complexities arise due to competing priorities, water rights, and transboundary water sources. [...] Read more.
The increasingly adverse impacts of climate change (e.g., rainfall patterns, droughts, and floods), coupled with the ever-increasing water demands, are often translated into a contingent liability for water users’ communities. Additional complexities arise due to competing priorities, water rights, and transboundary water sources. Therefore, conventional water management practices should shift toward more comprehensive and responsive integrative approaches, even for systems with limited data. Furthermore, water managers must prioritize dynamic and interactive management techniques for existing systems. One such management technique is water banking, which is the focus of this study. Herein, a dynamic interactive water allocation model, which encompasses the water managers and heterogeneous parties with competing demands, is developed. The voluntary sales of water shares between parties are illustrated through the specific case of the Medjerda River in Tunisia, an excellent example of a transboundary basin with limited hydrologic data and conflicting water use requirements between its upstream and downstream sectors. A set of scenarios is developed for the first analysis with this model: two management scenarios that include the no-water trade and the water banking option; three demand scenarios that include a combination of steady-, low-, and high-water demand conditions; and two hydrologic scenarios that include dry and wet conditions. Based on an economic model, the economic impacts of water banking are calculated using estimates of the costs of water shortages brought to users that illustrate the magnitude. The results show that the water banking technique can improve water resource availability by optimizing the management, operation, and conservation of natural and artificial water storage systems and water distribution infrastructure. Specifically, water banking can offset users’ profit losses during severe conditions (i.e., drought), even with limited hydrologic data. This water management technique would allow the Tunisian government to minimize the economic impacts on farmers from drought and to plan for future uncertainties by optimizing the water storage potential in years of abundant rainfall. Full article
(This article belongs to the Section Sustainable Water Management)
20 pages, 29850 KiB  
Article
Comprehensive Performance Evaluation between Visual SLAM and LiDAR SLAM for Mobile Robots: Theories and Experiments
by Yu-Lin Zhao, Yi-Tian Hong and Han-Pang Huang
Appl. Sci. 2024, 14(9), 3945; https://doi.org/10.3390/app14093945 (registering DOI) - 06 May 2024
Abstract
SLAM (Simultaneous Localization and Mapping), primarily relying on camera or LiDAR (Light Detection and Ranging) sensors, plays a crucial role in robotics for localization and environmental reconstruction. This paper assesses the performance of two leading methods, namely ORB-SLAM3 and SC-LeGO-LOAM, focusing on localization [...] Read more.
SLAM (Simultaneous Localization and Mapping), primarily relying on camera or LiDAR (Light Detection and Ranging) sensors, plays a crucial role in robotics for localization and environmental reconstruction. This paper assesses the performance of two leading methods, namely ORB-SLAM3 and SC-LeGO-LOAM, focusing on localization and mapping in both indoor and outdoor environments. The evaluation employs artificial and cost-effective datasets incorporating data from a 3D LiDAR and an RGB-D (color and depth) camera. A practical approach is introduced for calculating ground-truth trajectories and during benchmarking, reconstruction maps based on ground truth are established. To assess the performance, ATE and RPE are utilized to evaluate the accuracy of localization; standard deviation is employed to compare the stability during the localization process for different methods. While both algorithms exhibit satisfactory positioning accuracy, their performance is suboptimal in scenarios with inadequate textures. Furthermore, 3D reconstruction maps established by the two approaches are also provided for direct observation of their differences and the limitations encountered during map construction. Moreover, the research includes a comprehensive comparison of computational performance metrics, encompassing Central Processing Unit (CPU) utilization, memory usage, and an in-depth analysis. This evaluation revealed that Visual SLAM requires more CPU resources than LiDAR SLAM, primarily due to additional data storage requirements, emphasizing the impact of environmental factors on resource requirements. In conclusion, LiDAR SLAM is more suitable for the outdoors due to its comprehensive nature, while Visual SLAM excels indoors, compensating for sparse aspects in LiDAR SLAM. To facilitate further research, a technical guide was also provided for the researchers in related fields. Full article
(This article belongs to the Section Robotics and Automation)
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13 pages, 1631 KiB  
Article
Natural Contamination of Rice with Ustiloxins and the Connection with Climate Conditions in Southern China
by Xuexue Miao, Ying Miao, Yang Liu, Shuhua Tao, Huabin Zheng, Na Kuang, Jiemin Wang and Qiyuan Tang
Agronomy 2024, 14(5), 976; https://doi.org/10.3390/agronomy14050976 (registering DOI) - 06 May 2024
Abstract
Mycotoxins often contaminate rice, which are the secondary metabolites of fungi. Ustiloxins, a type of mycotoxin that has often been overlooked, pose a significant risk to human health. Therefore, identifying and controlling the pollution of ustiloxins in rice is required. In this study, [...] Read more.
Mycotoxins often contaminate rice, which are the secondary metabolites of fungi. Ustiloxins, a type of mycotoxin that has often been overlooked, pose a significant risk to human health. Therefore, identifying and controlling the pollution of ustiloxins in rice is required. In this study, we examined the natural contamination of rice with ustiloxins and their link to climate conditions. A total of 300 paddy samples were collected from six regions in southern China, and concentrations of ustiloxins A, B, C, D, and F were analyzed by liquid chromatography–tandem mass spectrometry (LC-MS/MS). Results showed that the occurrence of ustiloxins A, B, C, D, and F in paddies was found to be 55.7%, 41.3%, 29.0%, 93.7%, and 96.7%, respectively. Ustiloxin A had the highest mean (177.8 µg/kg) and maximum (3620.9 µg/kg) concentration, followed, in order, by ustiloxins C, B, D, and F. Furthermore, ustiloxin levels were significantly different depending on their origin, with the highest concentration in rice from Changde and Yueyang. And the regional difference in ustiloxins was related to the diversity of climate. A positive correlation between ustiloxin occurrence and mean humidity and precipitation was found in July and August of different regions, while mean temperature indicated a negative dependence. This is an essential survey of the contamination of rice with ustiloxins throughout southern China. The influence of climatic conditions on ustiloxins contamination was evaluated for the first time in our study. Overall, the rice samples examined in this study exhibited a high distribution of ustiloxins, suggesting that regulatory limits and the establishment of maximum allowable levels of ustiloxins in rice are necessary. This study provides a basis and guidance for the pollution situation and control strategy of ustiloxins in China. Full article
(This article belongs to the Section Agricultural Biosystem and Biological Engineering)
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22 pages, 2821 KiB  
Article
Enhancing Fetal Electrocardiogram Signal Extraction Accuracy through a CycleGAN Utilizing Combined CNN–BiLSTM Architecture
by Yuyao Yang, Lin Chen and Shuicai Wu
Sensors 2024, 24(9), 2948; https://doi.org/10.3390/s24092948 (registering DOI) - 06 May 2024
Abstract
The fetal electrocardiogram (FECG) records changes in the graph of fetal cardiac action potential during conduction, reflecting the developmental status of the fetus in utero and its physiological cardiac activity. Morphological alterations in the FECG can indicate intrauterine hypoxia, fetal distress, and neonatal [...] Read more.
The fetal electrocardiogram (FECG) records changes in the graph of fetal cardiac action potential during conduction, reflecting the developmental status of the fetus in utero and its physiological cardiac activity. Morphological alterations in the FECG can indicate intrauterine hypoxia, fetal distress, and neonatal asphyxia early on, enhancing maternal and fetal safety through prompt clinical intervention, thereby reducing neonatal morbidity and mortality. To reconstruct FECG signals with clear morphological information, this paper proposes a novel deep learning model, CBLS-CycleGAN. The model’s generator combines spatial features extracted by the CNN with temporal features extracted by the BiLSTM network, thus ensuring that the reconstructed signals possess combined features with spatial and temporal dependencies. The model’s discriminator utilizes PatchGAN, employing small segments of the signal as discriminative inputs to concentrate the training process on capturing signal details. Evaluating the model using two real FECG signal databases, namely “Abdominal and Direct Fetal ECG Database” and “Fetal Electrocardiograms, Direct and Abdominal with Reference Heartbeat Annotations”, resulted in a mean MSE and MAE of 0.019 and 0.006, respectively. It detects the FQRS compound wave with a sensitivity, positive predictive value, and F1 of 99.51%, 99.57%, and 99.54%, respectively. This paper’s model effectively preserves the morphological information of FECG signals, capturing not only the FQRS compound wave but also the fetal P-wave, T-wave, P-R interval, and ST segment information, providing clinicians with crucial diagnostic insights and a scientific foundation for developing rational treatment protocols. Full article
(This article belongs to the Section Biomedical Sensors)
14 pages, 3566 KiB  
Article
Effect of Climate Evolution on the Dynamics of the Wildfires in Greece
by Nikolaos Iliopoulos, Iasonas Aliferis and Michail Chalaris
Fire 2024, 7(5), 162; https://doi.org/10.3390/fire7050162 (registering DOI) - 06 May 2024
Abstract
Understanding the potential effects of climate change on forest fire behavior and the resulting release of combustion products is critical for effective mitigation strategies in Greece. This study utilizes data from the MAGICC 2.4 (Model for the Assessment of Greenhouse Gas-Induced Climate Change) [...] Read more.
Understanding the potential effects of climate change on forest fire behavior and the resulting release of combustion products is critical for effective mitigation strategies in Greece. This study utilizes data from the MAGICC 2.4 (Model for the Assessment of Greenhouse Gas-Induced Climate Change) climate model and the SCENGEN 2.4 (SCENarioGENerator) database to assess these impacts. By manipulating various model parameters such as climate sensitivity, scenario, time period, and global climate models (GCMs) within the SCENGEN 2.4 database, we analyzed climatic trends affecting forest fire generation and evolution. The results reveal complex and nuanced findings, indicating a need for further investigation. Case studies are conducted using the FARSITE 4 (Fire Area Simulator) model, incorporating meteorological changes derived from climate trends. Simulations of two fires in East Attica, accounting for different fuel and meteorological conditions, demonstrate an increase in the rate of combustion product release. This underscores the influence of changing meteorological parameters on forest fire dynamics and highlights the importance of proactive measures to mitigate future risks. Our findings emphasize the urgency of addressing climate change impacts on wildfire behavior to safeguard environmental and public health in Greece. Full article
(This article belongs to the Special Issue Effects of Climate Change on Fire Danger)
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