The 2023 MDPI Annual Report has
been released!
 
18 pages, 3973 KiB  
Article
Self-Consistent Model for the Compositional Profiles in Vapor–Liquid–Solid III–V Nanowire Heterostructures Based on Group V Interchange
by Vladimir G. Dubrovskii
Nanomaterials 2024, 14(10), 821; https://doi.org/10.3390/nano14100821 (registering DOI) - 07 May 2024
Abstract
Due to the very efficient relaxation of elastic stress on strain-free sidewalls, III–V nanowires offer almost unlimited possibilities for bandgap engineering in nanowire heterostructures by using material combinations that are attainable in epilayers. However, axial nanowire heterostructures grown using the vapor–liquid–solid method often [...] Read more.
Due to the very efficient relaxation of elastic stress on strain-free sidewalls, III–V nanowires offer almost unlimited possibilities for bandgap engineering in nanowire heterostructures by using material combinations that are attainable in epilayers. However, axial nanowire heterostructures grown using the vapor–liquid–solid method often suffer from the reservoir effect in a catalyst droplet. Control over the interfacial abruptness in nanowire heterostructures based on the group V interchange is more difficult than for group-III-based materials, because the low concentrations of highly volatile group V atoms cannot be measured after or during growth. Here, we develop a self-consistent model for calculations of the coordinate-dependent compositional profiles in the solid and liquid phases during the vapor–liquid–solid growth of the axial nanowire heterostructure Ax0B1-x0C/Ax1B1-x1C with any stationary compositions x0 and x1. The only assumption of the model is that the growth rates of both binaries AC and BC are proportional to the concentrations of group V atoms A and B in a catalyst droplet, requiring high enough supersaturations in liquid phase. The model contains a minimum number of parameters and fits quite well the data on the interfacial abruptness across double heterostructures in GaP/GaAsxP1-x/GaP nanowires. It can be used for any axial III–V nanowire heterostructures obtained through the vapor–liquid–solid method. It forms a basis for further developments in modeling the complex growth process and suppression of the interfacial broadening caused by the reservoir effect. Full article
(This article belongs to the Section Nanoelectronics, Nanosensors and Devices)
20 pages, 5969 KiB  
Article
Ziziphus jujuba Miller Ethanol Extract Restores Disrupted Intestinal Barrier Function via Tight Junction Recovery and Reduces Inflammation
by Ye Jin Yang, Min Jung Kim, Ho Jeong Lee, Won-Yung Lee, Ju-Hye Yang, Hun Hwan Kim, Min Sup Shim, Ji Woong Heo, Jae Dong Son, Woo H. Kim, Gon Sup Kim, Hu-Jang Lee, Young-Woo Kim, Kwang Youn Kim and Kwang Il Park
Antioxidants 2024, 13(5), 575; https://doi.org/10.3390/antiox13050575 (registering DOI) - 07 May 2024
Abstract
Inflammatory bowel disease (IBD) is a chronic inflammatory condition caused by the disruption of the intestinal barrier. The intestinal barrier is maintained by tight junctions (TJs), which sustain intestinal homeostasis and prevent pathogens from entering the microbiome and mucosal tissues. Ziziphus jujuba Miller [...] Read more.
Inflammatory bowel disease (IBD) is a chronic inflammatory condition caused by the disruption of the intestinal barrier. The intestinal barrier is maintained by tight junctions (TJs), which sustain intestinal homeostasis and prevent pathogens from entering the microbiome and mucosal tissues. Ziziphus jujuba Miller (Z. jujuba) is a natural substance that has been used in traditional medicine as a therapy for a variety of diseases. However, in IBD, the efficacy of Z. jujuba is unknown. Therefore, we evaluated ZJB in Caco2 cells and a dextran sodium sulfate (DSS)-induced mouse model to demonstrate its efficacy in IBD. Z. jujuba extracts were prepared using 70% ethanol and were named ZJB. ZJB was found to be non-cytotoxic and to have excellent antioxidant effects. We confirmed its anti-inflammatory properties via the down-regulation of inflammatory factors, including inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). To evaluate the effects of ZJB on intestinal barrier function and TJ improvement, the trans-epithelial electrical resistance (TEER) and fluorescein isothiocyanate-dextran 4 kDa (FITC-Dextran 4) permeability were assessed. The TEER value increased by 61.389% and permeability decreased by 27.348% in the 200 μg/mL ZJB group compared with the 50 ng/mL IL-6 group after 24 h. Additionally, ZJB alleviated body weight loss, reduced the disease activity index (DAI) score, and induced colon shortening in 5% DSS-induced mice; inflammatory cytokines, tumor necrosis factor (TNF)-α, and interleukin (IL)-6 were down-regulated in the serum. TJ proteins, such as Zonula occludens (ZO)-1 and occludin, were up-regulated by ZJB in an impaired Caco2 mouse model. Additionally, according to the liquid chromatography results, in tandem with mass spectrometry (LC-MS/MS) analysis, seven active ingredients were detected in ZJB. In conclusion, ZJB down-regulated inflammatory factors, protected intestinal barrier function, and increased TJ proteins. It is thus a safe, natural substance with the potential to be used as a therapeutic agent in IBD treatment. Full article
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13 pages, 6234 KiB  
Article
Investigation of the Influence of Alloy Atomic Doping on the Properties of Cu-Sn Alloys Based on First Principles
by Zongfan Wei, Jiaying Chen, Jingteng Xue, Nan Qu, Yong Liu, Ling Sun, Yuchen Xiao, Baoan Wu, Jingchuan Zhu and Huiyi Tang
Metals 2024, 14(5), 552; https://doi.org/10.3390/met14050552 (registering DOI) - 07 May 2024
Abstract
In order to design Cu-Sn alloys with excellent overall performance, the structural stability, mechanical properties, and electronic structure of X-doped Cu-Sn alloys were systematically calculated using first-principles calculations. The calculation results of the cohesive energy indicate that the Cu-Sn-X structures formed by X [...] Read more.
In order to design Cu-Sn alloys with excellent overall performance, the structural stability, mechanical properties, and electronic structure of X-doped Cu-Sn alloys were systematically calculated using first-principles calculations. The calculation results of the cohesive energy indicate that the Cu-Sn-X structures formed by X atoms (X = Ag, Ca, Cd, Mg, Ni, Zr) doping into Cu-Sn can stably exist. The Cu-Sn-Ni structure is the most stable, with a cohesive energy value of −3.84 eV. Doping of X atoms leads to a decrease in the bulk modulus, Possion’s ratio and B/G ratio. However, doping Ag and Ni atoms can improve the shear modulus, Young’s modulus, and strain energy of the dislocation. The doping of Ni has the highest enhancement on shear modulus, Young’s modulus, and strain energy of the dislocation, with respective values as follows: 63.085 GPa, 163.593 GPa, and 1.689 W/J·m1. The analysis of electronic structure results shows that the covalent bond between Cu and X is the reason for the performance differences in Cu-Sn-X structures. Full article
(This article belongs to the Section Computation and Simulation on Metals)
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17 pages, 758 KiB  
Article
Theme Exploration and Sentiment Analysis of Online Reviews of Wuyishan National Park
by Wei Fu and Bin Zhou
Land 2024, 13(5), 629; https://doi.org/10.3390/land13050629 (registering DOI) - 07 May 2024
Abstract
The study aimed to explore the relationship and interaction between humans and nature in specific areas. Latent Dirichlet allocation topic recognition and SnowNLP sentiment analysis were used to extract the topics and analyze the sentiments from visitors’ online reviews of Wuyishan National Park. [...] Read more.
The study aimed to explore the relationship and interaction between humans and nature in specific areas. Latent Dirichlet allocation topic recognition and SnowNLP sentiment analysis were used to extract the topics and analyze the sentiments from visitors’ online reviews of Wuyishan National Park. The conclusions were as follows: (1) The tourists mainly expressed positive emotions toward Wuyishan National Park, and the tourists acknowledged its ecological environment and natural and cultural heritage value. (2) The tourists’ comments focused on four themes: tourism activities and facilities, natural and cultural heritage value, characteristic tourism products, and tourism management and services. Natural experience was the main tourism activity in Wuyishan National Park, while cultural activities were related to the tea culture. (3) The tourist facilities, ticket and reservation mechanism, and management and services of Wuyishan National Park were the main concerns of the tourists. The study suggested that Wuyishan National Park could be transformed from a tourist destination into a comprehensive national park that provides recreational experiences and environmental education. This should be conducted by (1) developing detailed natural and cultural education and experience products and (2) improving public service functions and enhancing the public welfare of the national park. Full article
12 pages, 398 KiB  
Article
Placebo Effect of Caffeine on Physiological Parameters and Physical Performance
by David Ortiz-Sánchez, Alfredo Bravo-Sánchez, María Ramírez-delaCruz, Pablo Abián and Javier Abián-Vicén
Nutrients 2024, 16(10), 1405; https://doi.org/10.3390/nu16101405 (registering DOI) - 07 May 2024
Abstract
This study aimed to analyse the placebo effect associated with a high dose of caffeine (9 mg/kg) on heart rate and its variability and on strength tests. Methods: 18 participants experienced in strength training (19.7 ± 2.3 years; 72.2 ± 15.0 kg; 169.6 [...] Read more.
This study aimed to analyse the placebo effect associated with a high dose of caffeine (9 mg/kg) on heart rate and its variability and on strength tests. Methods: 18 participants experienced in strength training (19.7 ± 2.3 years; 72.2 ± 15.0 kg; 169.6 ± 9.0 cm) performed two days of trials (caffeine-informed/placebo-ingested (placebo) and non-ingested (control)). Firstly, heart rate and its variability were measured while participants lay down for 15 min. After that, bench press and squat tests were performed at 3 different loads (50%, 75% and 90% of 1RM). Perception of performance, effort and side effects were also evaluated. Results: no differences were found in the vast majority of strength variables analysed. Resting heart rate decreased in the placebo trial (60.39 ± 10.18 bpm control vs. 57.56 ± 9.50 bpm placebo, p = 0.040), and mean RR increased (1020.1 ± 172.9 ms control vs. 1071.5 ± 185.7 ms placebo, p = 0.032). Heart rate variability and perception of performance and effort were similar between conditions (p > 0.05 in all cases). Side effects such as activeness and nervousness were reported while consuming the placebo. Conclusions: the placebo effect did not modify performance in the majority of the strength test variables, HRV and perception of performance and effort. However, resting heart rate was reduced, mean RR increased, and some side effects appeared in the placebo trial. Full article
20 pages, 6721 KiB  
Article
Porcine Model of Cerebral Ischemic Stroke Utilizing Intracortical Recordings for the Continuous Monitoring of the Ischemic Area
by Thomas Gomes Nørgaard dos Santos Nielsen, Numa Dancause, Taha Al Muhammadee Janjua, Felipe Rettore Andreis, Benedict Kjærgaard and Winnie Jensen
Sensors 2024, 24(10), 2967; https://doi.org/10.3390/s24102967 (registering DOI) - 07 May 2024
Abstract
Purpose: Our aim was to use intracortical recording to enable the tracking of ischemic infarct development over the first few critical hours of ischemia with a high time resolution in pigs. We employed electrophysiological measurements to obtain quick feedback on neural function, which [...] Read more.
Purpose: Our aim was to use intracortical recording to enable the tracking of ischemic infarct development over the first few critical hours of ischemia with a high time resolution in pigs. We employed electrophysiological measurements to obtain quick feedback on neural function, which might be useful for screening, e.g., for the optimal dosage and timing of agents prior to further pre-clinical evaluation. Methods: Micro-electrode arrays containing 16 (animal 1) or 32 electrodes (animal 2–7) were implanted in the primary somatosensory cortex of seven female pigs, and continuous electrical stimulation was applied at 0.2 Hz to a cuff electrode implanted on the ulnar nerve. Ischemic stroke was induced after 30 min of baseline recording by injection of endothelin-1 onto the cortex adjacent to the micro-electrode array. Evoked responses were extracted over a moving window of 180 s and averaged across channels as a measure of cortical excitability. Results: Across the animals, the cortical excitability was significantly reduced in all seven 30 min segments following endothelin-1 injection, as compared to the 30 min preceding this intervention. This difference was not explained by changes in the anesthesia, ventilation, end-tidal CO2, mean blood pressure, heart rate, blood oxygenation, or core temperature, which all remained stable throughout the experiment. Conclusions: The animal model may assist in maturing neuroprotective approaches by testing them in an accessible model of resemblance to human neural and cardiovascular physiology and body size. This would constitute an intermediate step for translating positive results from rodent studies into human application, by more efficiently enabling effective optimization prior to chronic pre-clinical studies in large animals. Full article
(This article belongs to the Special Issue Feature Papers in Biosensors Section 2024)
18 pages, 1221 KiB  
Article
A Comprehensive Approach to Azo Dichlorotriazine Dye Treatment: Assessing the Impact of Physical, Chemical, and Biological Treatment Methods through Statistical Analysis of Experimental Data
by Gamal K. Hassan, Montaser Y. Ghaly, Ghada E. Ahmed, Rehab M. Mohamed, Heba A. El-Gawad, Przemysław Kowal, Hussein E. Al-Hazmi and Ahmed A. Afify
Water 2024, 16(10), 1327; https://doi.org/10.3390/w16101327 (registering DOI) - 07 May 2024
Abstract
This exploration investigates integrated treatment systems combining advanced oxidation processes (Fenton and photo-Fenton) with biological methods for the effective elimination of stubborn organic compounds in simulated textile wastewater composed of azo Dichlorotriazine dye. A comprehensive optimization of key process factors including catalyst dosage, [...] Read more.
This exploration investigates integrated treatment systems combining advanced oxidation processes (Fenton and photo-Fenton) with biological methods for the effective elimination of stubborn organic compounds in simulated textile wastewater composed of azo Dichlorotriazine dye. A comprehensive optimization of key process factors including catalyst dosage, hydrogen peroxide quantity, irradiation duration, etc. was systematically conducted for both Fenton and photo-Fenton processes to realize maximum COD and color removal. Under ideal conditions (0.4 g/L photocatalyst, 1 mL/L H2O2, and 75-Watt UV intensity for 60 min), the photo-Fenton process realized 80% COD elimination and complete decolorization, meeting industrial discharge limits without needing extra biological treatment. Statistical models correlating process parameters to treatment efficiency were developed, giving important design insights. For Fenton, effluent COD exceeded discharge thresholds, so a post-biological treatment using activated sludge was essential to comply with regulations. This integrated Fenton–biological scheme utilizes synergism between chemical and biological processes for enhanced overall treatment. Notable economic benefits were achieved by photo-Fenton over conventional UV-only and UV/H2O2 methods regarding energy consumption and operating costs. Overall, this pioneering work successfully proves integrated advanced oxidation–biological systems as a superior, sustainable alternative to traditional techniques for economically removing obstinate pollutants, such as azo Dichlorotriazine dye, as it is a simulated textile wastewater treatment used to satisfy environmental standards. Full article
(This article belongs to the Special Issue Wastewater Treatment Technologies: Theory, Methods and Applications)
12 pages, 479 KiB  
Article
A New Species of the Genus Takydromus (Squamata: Lacertidae) from Northeastern Guangxi, China
by Kun Guo, Yong-Hao Hu, Jian Chen, Jun Zhong and Xiang Ji
Animals 2024, 14(10), 1402; https://doi.org/10.3390/ani14101402 (registering DOI) - 07 May 2024
Abstract
During our collecting trip to Guangxi in 2016, we collected ten specimens of the genus Takydromus from the suburb of Guilin, northeastern Guangxi, South China, and found that they did not belong to any currently known species. Here, we described this new species, [...] Read more.
During our collecting trip to Guangxi in 2016, we collected ten specimens of the genus Takydromus from the suburb of Guilin, northeastern Guangxi, South China, and found that they did not belong to any currently known species. Here, we described this new species, Takydromus guilinensis sp. nov., based on morphological and mitochondrial DNA (CO1 and cyt b) data. This new species is a sister taxon to T. intermedius with a p-distance of 0.070 in CO1 and 0.080 in cyt b. These two p-distances exceed not only the minimum value (0.067) between T. septentrionalis and T. stejnegeri but also the minimum value (0.079) between T. intermedius and T. yunkaiensis. Morphologically, this new species differs from other currently recognized Takydromus species from the same clade, more evidently in the longitudinal rows of dorsal scales, transverse rows of scales at the mid-body and mensural variables. The description of Takydromus guilinensis sp. nov. increases the total number of Takydromus species to 25, of which 16 can be found in China. Takydromus guilinensis sp. nov. is currently known only from Guilin, Guangxi, South China, where it is sympatric with the other four Takydromus species (T. septentrionalis, T. kuehnei, T. sexlineatus and T. intermedius). Full article
(This article belongs to the Section Herpetology)
37 pages, 1026 KiB  
Article
Implications of the Progression to Sustainable Public Transportation: An Insight into Modern Jeepney Shift from the Philippines
by Tricia Mae T. Zulueta, Ardvin Kester S. Ong, Josephine D. German, Ma. Janice J. Gumasing and Jenn Christzel D. Chico
Sustainability 2024, 16(10), 3912; https://doi.org/10.3390/su16103912 (registering DOI) - 07 May 2024
Abstract
Modern jeepneys represent a notable step forward in the Philippines’ modernization efforts. However, there is a need for further study since this has caused a lot of criticism in the country, and no studies have established its service quality and the behavioral intentions [...] Read more.
Modern jeepneys represent a notable step forward in the Philippines’ modernization efforts. However, there is a need for further study since this has caused a lot of criticism in the country, and no studies have established its service quality and the behavioral intentions among passengers. This study assessed the factors influencing passengers’ intention to use modern jeepneys, employing a higher-order reflective construct using partial least square structural equation modeling. An online questionnaire gathered data from 502 commuters using modern jeepneys, employing convenience sampling for a diverse sample. Significant relationships (p-value < 0.05) were found between service quality (β: 0.559), attitude (β: 0.169), perceived behavioral control (β: 0.183), and behavioral intentions (β: 0.160), with assurance emerging as the most influential factor for higher-ordered constructs (β: 0.869). Meanwhile, satisfaction’s significant influence on behavioral intention was highest for lower-ordered constructs (β: 0.673). The study underscored the importance of building trust with passengers, prioritizing safety and security, and integrating modern jeepneys with traditional designs to enhance commuter experiences and promote modernized and sustainable transportation alternatives. It highlights the critical role of providing high-quality service in fostering positive intentions toward using modern jeepneys and its utilization. Despite the backlash of the majority on the redevelopment of traditional jeepneys, results presented that passengers are more inclined to use public transportation based on travel experiences rather than societal approval. The study offers theoretical and practical implications for future works and government organizations, transportation management, and modern jeepney manufacturers, emphasizing the importance of improving service quality. Full article
(This article belongs to the Collection Sustainability in Urban Transportation Planning)
20 pages, 2991 KiB  
Article
Morphological and Molecular Characters Differentiate Common Morphotypes of Atlantic Holopelagic Sargassum
by Amy N. S. Siuda, Aurélie Blanfuné, Skye Dibner, Marc Verlaque, Charles-François Boudouresque, Solène Connan, Deborah S. Goodwin, Valérie Stiger-Pouvreau, Frédérique Viard, Florence Rousseau, Valérie Michotey, Jeffrey M. Schell, Thomas Changeaux, Didier Aurelle and Thierry Thibaut
Phycology 2024, 4(2), 256-275; https://doi.org/10.3390/phycology4020014 - 07 May 2024
Abstract
Since 2011, massive new strandings of holopelagic Sargassum have been reported on the coasts of the Caribbean, northern Brazil, Guiana, and West Africa, causing severe economic and ecological damage. Three common morphotypes (S. fluitans III, S. natans I, and S. natans VIII) [...] Read more.
Since 2011, massive new strandings of holopelagic Sargassum have been reported on the coasts of the Caribbean, northern Brazil, Guiana, and West Africa, causing severe economic and ecological damage. Three common morphotypes (S. fluitans III, S. natans I, and S. natans VIII) were identified as responsible for these catastrophic events, with dominance shifts between them over time. However, the taxonomic status of these holopelagic Sargassum morphotypes remains unclear. Using an integrative taxonomy framework, combining a morphological study and molecular analyses, this study aimed to clarify their taxonomic status. Morphological analyses of 54 characters revealed no intermediate form between the three morphotypes, with the overall shape, nature of the axis, and size and shape of blades and vesicles being the most discriminating. An analysis of mitochondrial (IGS, cox2, cox3, mt16S rRNA, and nad6) and plastid (rbcL) markers confirmed the genetic divergence among the three morphotypes, with a lower level of divergence between the two S. natans morphotypes. Without additional molecular characterization, these morphotypes cannot be classified as three distinct species. However, due to their distinct morphological characteristics and sympatry within drifting aggregations, a revision of holopelagic species names is proposed, with Sargassum fluitans var. fluitans (for S. fluitans III), Sargassum natans var. natans (for S. natans I), and S. natans var. wingei (for S. natans VIII). This revision provides necessary clarity on the species involved in inundations of the tropical Atlantic. Full article
(This article belongs to the Collection Sargassum Golden Tides, a Global Problem)
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20 pages, 5048 KiB  
Article
An Accurate Representation of the Number of bZIP Transcription Factors in the Triticum aestivum (Wheat) Genome and the Regulation of Functional Genes during Salt Stress
by Xin Liu, Selvakumar Sukumaran, Esteri Viitanen, Nupur Naik, Sameer Hassan and Henrik Aronsson
Curr. Issues Mol. Biol. 2024, 46(5), 4417-4436; https://doi.org/10.3390/cimb46050268 - 07 May 2024
Abstract
Climate change is dramatically increasing the overall area of saline soils around the world, which is increasing by approximately two million hectares each year. Soil salinity decreases crop yields and, thereby, makes farming less profitable, potentially causing increased poverty and hunger in many [...] Read more.
Climate change is dramatically increasing the overall area of saline soils around the world, which is increasing by approximately two million hectares each year. Soil salinity decreases crop yields and, thereby, makes farming less profitable, potentially causing increased poverty and hunger in many areas. A solution to this problem is increasing the salt tolerance of crop plants. Transcription factors (TFs) within crop plants represent a key to understanding salt tolerance, as these proteins play important roles in the regulation of functional genes linked to salt stress. The basic leucine zipper (bZIP) TF has a well-documented role in the regulation of salt tolerance. To better understand how bZIP TFs are linked to salt tolerance, we performed a genome-wide analysis in wheat using the Chinese spring wheat genome, which has been assembled by the International Wheat Genome Sequencing Consortium. We identified 89 additional bZIP gene sequences, which brings the total of bZIP gene sequences in wheat to 237. The majority of these 237 sequences included a single bZIP protein domain; however, different combinations of five other domains also exist. The bZIP proteins are divided into ten subfamily groups. Using an in silico analysis, we identified five bZIP genes (ABF2, ABF4, ABI5, EMBP1, and VIP1) that were involved in regulating salt stress. By scrutinizing the binding properties to the 2000 bp upstream region, we identified putative functional genes under the regulation of these TFs. Expression analyses of plant tissue that had been treated with or without 100 mM NaCl revealed variable patterns between the TFs and functional genes. For example, an increased expression of ABF4 was correlated with an increased expression of the corresponding functional genes in both root and shoot tissues, whereas VIP1 downregulation in root tissues strongly decreased the expression of two functional genes. Identifying strategies to sustain the expression of the functional genes described in this study could enhance wheat’s salt tolerance. Full article
(This article belongs to the Special Issue Advanced Research in Wheat Genome and Breeding)
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14 pages, 1415 KiB  
Article
Algal Oil Mitigates Sodium Taurocholate-Induced Pancreatitis by Alleviating Calcium Overload, Oxidative Stress, and NF-κB Activation in Pancreatic Acinar Cells
by Yi Fang, Sung-Yen Lin, Chung-Hwan Chen and Hui-Chen Lo
Curr. Issues Mol. Biol. 2024, 46(5), 4403-4416; https://doi.org/10.3390/cimb46050267 - 07 May 2024
Abstract
Acute pancreatitis (AP) is characterized by elevated intracellular Ca2+ concentrations, mitochondrial dysfunction, and oxidative stress in pancreatic acinar cells. Algal oil (AO) has demonstrated antioxidant and anti-inflammatory properties. This study aims to explore the effects of algal oil on the microenvironment of [...] Read more.
Acute pancreatitis (AP) is characterized by elevated intracellular Ca2+ concentrations, mitochondrial dysfunction, and oxidative stress in pancreatic acinar cells. Algal oil (AO) has demonstrated antioxidant and anti-inflammatory properties. This study aims to explore the effects of algal oil on the microenvironment of AP. Rat pancreatic acinar AR42J cells were pretreated with AO containing 0, 50, 100, or 150 μM of docosahexaenoic acid (DHA) 2 h prior to AP induction using sodium taurocholate (STC). After 1 h of STC treatment, AR42J cells exhibited a significant increase in intracellular Ca2+ concentration and the production of amylase, lipase, reactive oxygen species, and pro-inflammatory mediators, including tumor necrosis factor-α and interleukin-6. These STC-induced increases were markedly reduced in cells pretreated with AO. In comparison to cells without AO, those treated with a high dose of AO before STC exposure demonstrated a significant increase in mitochondrial membrane potential and a decrease in lipid peroxidation. Furthermore, STC-activated nuclear factor kappa-B (NF-κB) was attenuated in AO-pretreated cells, as evidenced by a significant decrease in activated NF-κB. In conclusion, AO may prevent damage to pancreatic acinar cells by alleviating intracellular Ca2+ overload, mitigating mitochondrial dysfunction, reducing oxidative stress, and attenuating NF-κB-targeted inflammation. Full article
(This article belongs to the Special Issue Molecular Research on Free Radicals and Oxidative Stress)
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8 pages, 1274 KiB  
Communication
Evaluation of the Plant Growth Regulator SPGP4 in Agricultural Crops: A Case Study in Oaxaca, México
by Guiee N. López-Castillo, Arnoldo Wong-Villareal, Judith Castellanos-Moguel, Gilberto Vela Correa, Sandra L. Cabrera-Hilerio, Mariana Miranda-Arámbula, Alan Carrasco-Carballo and Jesús Sandoval-Ramírez
Crops 2024, 4(2), 172-179; https://doi.org/10.3390/crops4020013 - 07 May 2024
Abstract
The search for new plant growth regulators is a cornerstone of agricultural research; however, laboratory studies rarely go on to be evaluated in the field. This is because greater production is required, as well as longer studies. Particularly, brassinosteroids present these difficulties, and [...] Read more.
The search for new plant growth regulators is a cornerstone of agricultural research; however, laboratory studies rarely go on to be evaluated in the field. This is because greater production is required, as well as longer studies. Particularly, brassinosteroids present these difficulties, and although they have been evaluated in crops with good results, their high production cost gives rise to the search for new alternatives. 22-Oxocholestanes such as SPGP4, previously used in silico and in vitro studies, have shown great potential, so their evaluation in crops grown from native seeds from the study region becomes of interest. Based on these data, SPGP4 was evaluated under crop conditions in three agricultural plots located on the Isthmus of Tehuantepec region, Oaxaca, México. The seeds were treated with a 0.5 mg/L aqueous solution of the 22-Oxocholestane compound SPGP4 by imbibition one night before sown. Later, 45 days after sowing, a solution of 0.5 mg/L at a rate of 200 L per hectare was applied. At the production level, the bean harvest showed an increase in the range of 21.0–38.1%, and the corn harvest increased between 22 and 32%. In addition, the latter also demonstrated an increase in biomass production, given the increase in diameter and height observed in the corn plant. This indicates that SPGP4 functions as a regulator of plant growth at the crop level to increase both seed and biomass production. Full article
19 pages, 545 KiB  
Review
An Overview of Approaches and Methods for the Cognitive Workload Estimation in Human–Machine Interaction Scenarios through Wearables Sensors
by Sabrina Iarlori, David Perpetuini, Michele Tritto, Daniela Cardone, Alessandro Tiberio, Manish Chinthakindi, Chiara Filippini, Luca Cavanini, Alessandro Freddi, Francesco Ferracuti, Arcangelo Merla and Andrea Monteriù
BioMedInformatics 2024, 4(2), 1155-1173; https://doi.org/10.3390/biomedinformatics4020064 - 07 May 2024
Abstract
Background: Human-Machine Interaction (HMI) has been an important field of research in recent years, since machines will continue to be embedded in many human actvities in several contexts, such as industry and healthcare. Monitoring in an ecological mannerthe cognitive workload (CW) of users, [...] Read more.
Background: Human-Machine Interaction (HMI) has been an important field of research in recent years, since machines will continue to be embedded in many human actvities in several contexts, such as industry and healthcare. Monitoring in an ecological mannerthe cognitive workload (CW) of users, who interact with machines, is crucial to assess their level of engagement in activities and the required effort, with the goal of preventing stressful circumstances. This study provides a comprehensive analysis of the assessment of CW using wearable sensors in HMI. Methods: this narrative review explores several techniques and procedures for collecting physiological data through wearable sensors with the possibility to integrate these multiple physiological signals, providing a multimodal monitoring of the individuals’CW. Finally, it focuses on the impact of artificial intelligence methods in the physiological signals data analysis to provide models of the CW to be exploited in HMI. Results: the review provided a comprehensive evaluation of the wearables, physiological signals, and methods of data analysis for CW evaluation in HMI. Conclusion: the literature highlighted the feasibility of employing wearable sensors to collect physiological signals for an ecological CW monitoring in HMI scenarios. However, challenges remain in standardizing these measures across different populations and contexts. Full article
(This article belongs to the Special Issue Feature Papers in Applied Biomedical Data Science)
16 pages, 436 KiB  
Review
Effect of Boxing Exercises on the Functional Ability and Quality of Life of Individuals with Parkinson’s Disease: A Systematic Review
by Nikolaos Chrysagis, Georgia Trompouki, Dimitris Petropaulis, George A. Koumantakis, Georgios Krekoukias, Georgios Theotokatos, Emmanouil Skordilis and Vasiliki Sakellari
Eur. J. Investig. Health Psychol. Educ. 2024, 14(5), 1295-1310; https://doi.org/10.3390/ejihpe14050085 - 07 May 2024
Abstract
Parkinson’s disease (PD) is a neurological disorder caused by the loss of dopamine-producing cells in the substantia nigra and characterized by motor and non-motor symptoms. Boxing is a type of complementary therapy to improve symptoms in PD. The purpose of the present study [...] Read more.
Parkinson’s disease (PD) is a neurological disorder caused by the loss of dopamine-producing cells in the substantia nigra and characterized by motor and non-motor symptoms. Boxing is a type of complementary therapy to improve symptoms in PD. The purpose of the present study was to examine the effect of boxing training on the functionality and quality of life of patients with PD. The literature search was performed on PubMed, Scopus, PEDro, Cochrane Library, and Google Scholar search engines. The PEDro scale was used to assess the methodological quality of the studies. This systematic review included three studies that examined disease severity, mobility, physical activity, balance, and quality of life. According to the PEDro scale criteria, the three articles included were of high methodological quality. Statistically significant improvements after the implementation of boxing training was shown for balance and quality of life in contrast to the other variables. Boxing training intervention programs had a positive effect on balance and quality of life in patients with PD; however, the results are conflicting regarding certain functionality variables. Therefore, it is necessary to conduct further research to examine the effectiveness of boxing training on the functionality and quality of life of patients with Parkinson’s disease. Full article
52 pages, 4744 KiB  
Article
Force Metrology with Plane Parallel Plates: Final Design Review and Outlook
by Hamid Haghmoradi, Hauke Fischer, Alessandro Bertolini, Ivica Galić, Francesco Intravaia, Mario Pitschmann, Raphael A. Schimpl and René I. P. Sedmik
Physics 2024, 6(2), 690-741; https://doi.org/10.3390/physics6020045 - 07 May 2024
Abstract
During the past few decades, abundant evidence for physics beyond the two standard models of particle physics and cosmology was found. Yet, we are tapping in the dark regarding our understanding of the dark sector. For more than a century, open problems related [...] Read more.
During the past few decades, abundant evidence for physics beyond the two standard models of particle physics and cosmology was found. Yet, we are tapping in the dark regarding our understanding of the dark sector. For more than a century, open problems related to the nature of the vacuum remained unresolved. As well as the traditional high-energy frontier and cosmology, technological advancement provides complementary access to new physics via high-precision experiments. Among the latter, the Casimir And Non-Newtonian force EXperiment (Cannex) has successfully completed its proof-of-principle phase and is going to commence operation soon. Benefiting from its plane parallel plate geometry, both interfacial and gravity-like forces are maximized, leading to increased sensitivity. A wide range of dark sector forces, Casimir forces in and out of thermal equilibrium, and gravity can be tested. This paper describes the final experimental design, its sensitivity, and expected results. Full article
(This article belongs to the Special Issue 75 Years of the Casimir Effect: Advances and Prospects)
18 pages, 1298 KiB  
Article
Position Correction Control of Permanent-Magnet Brushless Motor Based on Commutation-Interval Current Symmetry
by Yongwu Guo, Yun Zhang and Xiaowei Li
World Electr. Veh. J. 2024, 15(5), 203; https://doi.org/10.3390/wevj15050203 - 07 May 2024
Abstract
With the needs of environmental protection and the adjustment of energy structure, new energy vehicles are playing an increasingly important role in the field of transportation today. The permanent-magnet brushless direct-current motor has the characteristics of high efficiency, and can be used in [...] Read more.
With the needs of environmental protection and the adjustment of energy structure, new energy vehicles are playing an increasingly important role in the field of transportation today. The permanent-magnet brushless direct-current motor has the characteristics of high efficiency, and can be used in the drive system of new energy vehicles or other auxiliary equipment. In the control process of the permanent-magnet brushless direct-current motor, based on a three-Hall position sensor, due to various factors, there are some errors in the Hall position signal, which must be corrected by appropriate measures. In this paper, the relationship between the position deviation in the commutation interval and the non-commutation-phase current is analyzed, and the current expressions in three different states are given. A new closed-loop compensation strategy for correcting the inaccurate commutation caused by the Hall signal error is proposed. Taking the position of a 30° electrical angle before and after the phase-change point as the H point, realizing the current symmetry within the 30° interval around the H point as the target and the sum of the slopes of the tangent lines at the two points symmetrical within the β (0 < β < 30) electrical angle around the H point as the deviation, a proportional-integral regulator is designed to correct the phase error of the phase-change signal. Finally, it is verified by experiments that the closed-loop compensation strategy proposed in this paper can effectively compensate the phase deviation of the commutation signal at a speed of about 2000 r/min, which improves the working efficiency of the motor to a certain extent. Full article
14 pages, 4923 KiB  
Article
Is There Safety Outside the “Safe Zone” in Total Hip Replacement? A Retrospective Observational Study
by Piotr Stępiński, Dawid Jegierski, Grzegorz Maciąg, Bartosz Maciąg, Olga Adamska and Artur Stolarczyk
Medicina 2024, 60(5), 772; https://doi.org/10.3390/medicina60050772 - 07 May 2024
Abstract
Background and Objectives: The safe zone in total hip replacement was introduced many years ago. Its aim was to provide guidelines for orthopedic surgeons in order to avoid complications such as instability. With the growing interest in spinopelvic alignment, some new insights [...] Read more.
Background and Objectives: The safe zone in total hip replacement was introduced many years ago. Its aim was to provide guidelines for orthopedic surgeons in order to avoid complications such as instability. With the growing interest in spinopelvic alignment, some new insights suggest that the safe zone is an obsolete concept. This study aims to show that, even outside the safe zone, the effect of total hip replacement can be satisfactory. This could be used as preliminary study for an analysis of a larger group. Materials and Methods: Fifty-nine consecutive patients with end-stage osteoarthritis treated by total hip replacement were enrolled into the study and divided into two groups: inside the safe zone and outside the safe zone. A physical examination during postoperative visits was performed; the range of movement was measured using a goniometer; and the HHS and VAS were taken to measure functional outcomes and pain, respectively. An analysis of the radiological outcomes was performed. Results: There was no significant difference in regard to changes in total offset, pain, HHS and other complications. There were no signs of instability among patients during the follow-up. Conclusions: The results of this study show that the “safe zone” is a more complicated term that was previously thought. A proper soft tissue balance and spinopelvic alignment could be factors that change the “safe zone” for each patient and make it more individual. Full article
(This article belongs to the Section Orthopedics)
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11 pages, 448 KiB  
Article
Insights from Chilean NCDs Hospitalization Data during COVID-19
by Jaime Andrés Vásquez-Gómez and Chiara Saracini
Medicina 2024, 60(5), 770; https://doi.org/10.3390/medicina60050770 - 07 May 2024
Abstract
The COVID-19 pandemic has affected the lifestyles of people of all ages, conditions and occupations. Social distance, remote working, changes in diet and a lack of physical activity have directly and indirectly affected many aspects of mental and physical health, particularly in patients [...] Read more.
The COVID-19 pandemic has affected the lifestyles of people of all ages, conditions and occupations. Social distance, remote working, changes in diet and a lack of physical activity have directly and indirectly affected many aspects of mental and physical health, particularly in patients with many comorbidities and non-communicable diseases (NCDs). In our paper, we analyzed COVID-19 hospitalized and non-hospitalized cases according to comorbidities to assess the average monthly percentage change (AMPC) and monthly percentage change (MPC) using open access data from the Chilean Ministry of Science, Technology, Knowledge and Innovation. As expected, the infection mainly affected patients with comorbidities, including cardiovascular risk factors. The hospitalized cases with obesity and chronic lung disease increased throughout the period of June 2020–August 2021 (AMPC = ↑20.8 and ↑19.4%, respectively, p < 0.05), as did all the non-hospitalized cases with comorbidities throughout the period (AMPC = ↑15.6 to ↑30.3 [p < 0.05]). The increases in hospitalizations and non-hospitalizations with comorbidities may be associated with physical inactivity. A healthy lifestyle with regular physical activity may have had a protective effect on the COVID-19 severity and related events in the post-pandemic period, especially for the NCD population. Full article
(This article belongs to the Special Issue Impact on Human Health, Lifestyle and Quality of Care after COVID-19)
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15 pages, 846 KiB  
Article
Quality-of-Life Assessment in Children with Mild to Moderate Bronchial Asthma
by Agnė Čibirkaitė, Vilija Bubnaitienė, Edita Hansted, Vaidotas Gurskis and Laimutė Vaidelienė
Medicina 2024, 60(5), 771; https://doi.org/10.3390/medicina60050771 - 07 May 2024
Abstract
Background and Objectives: Assess the quality of life of children aged 2–10 with mild to moderate bronchial asthma. To evaluate the general health condition of children with mild and moderate severity bronchial asthma. To determine health changes in children with mild- and moderate-severity [...] Read more.
Background and Objectives: Assess the quality of life of children aged 2–10 with mild to moderate bronchial asthma. To evaluate the general health condition of children with mild and moderate severity bronchial asthma. To determine health changes in children with mild- and moderate-severity bronchial asthma as they grow older. To evaluate the impact of mild- and moderate-severity bronchial asthma on children’s daily and social activities, physical health, emotional state, and general well-being. Materials and Methods: A comparative cross-sectional study was conducted in March–June 2020. Parents or guardians of 2–10-year-old children without bronchial asthma and children with mild to moderate bronchial asthma were interviewed after receiving their written informed consent. The questionnaire was based on the standardized quality-of-life quiz SF-36. A total of 248 questionnaires were collected—106 from the parents or guardians of children with bronchial asthma and 142 from parents/guardians of children without bronchial asthma. For further analysis, 106 children without bronchial asthma and with no chronic conditions were selected. Quantitative variables were compared using the Mann–Whitney U test and qualitative data using the chi-square (χ2) criteria. Quantitative data were described by giving means, medians, and standard deviations (SD); qualitative features by giving relative frequencies. Statistical data were analyzed using SPSS and Excel 2020. Results: Children with mild and moderate asthma exhibit poorer health compared to their healthy counterparts. Only 20.7% of respondents with asthma reported excellent or very good health, contrasting with 64.1% of healthy children (p < 0.001). As children with asthma age, their general condition improves, with 46.2% showing improvement in the past year, while 42.5% of healthy children had a stable condition (p < 0.05). In various activities, children with asthma face more constraints than healthy children (p < 0.05), including energetic activities (sick—59.5%; healthy—10.3%), moderate activities (sick—24.5%; healthy—4.7%), climbing stairs (sick—22.7%; healthy—3.8%), and walking over 100 m (sick—9.4%; healthy—0%). Children with asthma are more likely to experience exhaustion, anxiety, tiredness, lack of energy, and restraint in public activities (p < 0.05). Conclusions: Parents/caregivers of children with mild to moderate bronchial asthma rate their health worse than those of healthy children do. As children with mild to moderate bronchial asthma grow, the disease impact on their overall well-being decreases. Children with mild to moderate bronchial asthma, compared to healthy children, experience more limitations in vigorous or moderate activities; face more difficulties climbing stairs or walking more than 100 m; frequently feel exhaustion, anxiety, fatigue, or lack of energy; and encounter restrictions in social activities. Full article
(This article belongs to the Section Pulmonary)
17 pages, 1185 KiB  
Review
Current Status of Research on Wildland Fire Impacts on Soil Environment and Soil Organisms and Hotspots Visualization Analysis
by Zhichao Cheng, Song Wu, Dan Wei, Hong Pan, Xiaoyu Fu, Xinming Lu and Libin Yang
Fire 2024, 7(5), 163; https://doi.org/10.3390/fire7050163 - 07 May 2024
Abstract
Ecosystems are frequently disturbed by fires that have an important impact on the soil environment and the composition of soil organisms. In order to provide a baseline for the current research and identify trends on the effects of wildland fire on soil environment [...] Read more.
Ecosystems are frequently disturbed by fires that have an important impact on the soil environment and the composition of soil organisms. In order to provide a baseline for the current research and identify trends on the effects of wildland fire on soil environment and biological changes, the available literature was identified from the Web of Science database, covering the period from 1998/1998/1999 (the year of the earliest publication in this field) to 2023. A bibliometric analysis was performed and the data were visually displayed for the number of publications, countries, authors, research institutions, and keywords representing research hotspots. Specifically, the effects of wildland fire on the soil environment, on soil microorganisms and on soil fauna were analyzed. The results show that the annual number of publications describing effects of wildland fire on the soil environment and on soil microorganisms are increasing over time, while those describing effects on soil fauna are fewer and their number remains constant. The largest number of papers originate from the United States, with the United States Department of Agriculture as the research institution with the largest output. The three authors with the largest number of publications are Stefan H. Doerr, Manuel Esteban Lucas-Borja and Jan Jacob Keizer. The research hotspots, as identified by keywords, are highly concentrated on wildfire, fire, organic matter, and biodiversity, amongst others. This study comprehensively analyzes the current situation of the research on the effects of wildland fire on changes in the soil environment and organisms, and provides reference for relevant scientific researchers in this trend and future research hotspots. Full article
(This article belongs to the Special Issue Effects of Fires on Forest Ecosystems)
14 pages, 646 KiB  
Article
Introduction of the Experimental Setup for the Investigation of the Novel Selective Melt Dispersion (SMD): A Directed Energy Deposition (DED) Process
by Sebastian F. Noller, Anja Pfennig and Matthias Dahlmeyer
Clean Technol. 2024, 6(2), 572-585; https://doi.org/10.3390/cleantechnol6020030 - 07 May 2024
Abstract
This study focuses on developing an experimental setup to investigate the Selective Melt Dispersion (SMD), a Directed Energy Deposition (DED) process. SMD as a means of in-process joining (IPJ) aims to integrate components and assemblies during additive manufacturing, combining the advantages of various [...] Read more.
This study focuses on developing an experimental setup to investigate the Selective Melt Dispersion (SMD), a Directed Energy Deposition (DED) process. SMD as a means of in-process joining (IPJ) aims to integrate components and assemblies during additive manufacturing, combining the advantages of various processes for eco-friendly and economical resource utilization. The research initially analyzed DED systems and defined requirements for subsystems and the overall system. Critical subsystems, including the energy source, material feed, and others, were sequentially developed, and a proof of concept involved building 20 stacked welded tracks, validated through micrograph analysis. The study concludes by evaluating and discussing the fulfillment of the defined requirements. The system comprises a centrally arranged vibration-assisted powder feed; a laterally arranged laser incidence at a 45° angle; a kinematic structure where all axes are arranged on the workpiece, so the powder supply does not require movement; and a shield gas supply. Full article
(This article belongs to the Topic Clean Energy Technologies and Assessment)
21 pages, 1610 KiB  
Article
Environmental Impacts Associated with the Production and Packing of Persian Lemon in Mexico through Life-Cycle Assessment
by Eduardo Castillo-González, Lorena De Medina-Salas, Mario Rafael Giraldi-Díaz, Raúl Velásquez-De La Cruz and José Rafael Jiménez-Ochoa
Clean Technol. 2024, 6(2), 551-571; https://doi.org/10.3390/cleantechnol6020029 - 07 May 2024
Abstract
In this study, the environmental impacts associated with the intensive production of Persian lemons are assessed, including the agricultural and packing phases of the fresh fruit. A life-cycle assessment (LCA) tool was used in accordance with the ISO 14040 and 14044 standards and [...] Read more.
In this study, the environmental impacts associated with the intensive production of Persian lemons are assessed, including the agricultural and packing phases of the fresh fruit. A life-cycle assessment (LCA) tool was used in accordance with the ISO 14040 and 14044 standards and implemented in SimaPro PhD (9.2) software. The life-cycle inventory database was primarily composed of data collected during field visits to local lemon orchards and the main packing company in the region. The functional unit was defined as 1 kg of packed fresh Persian lemons. The selected impact categories were the carbon footprint, water footprint, and energy footprint, and the results obtained for the defined functional unit were 405.8 g CO2 eq, 40.3 L of water, and 5.9 MJ, respectively. The industrial packing phase of the fruits had a greater impact on the carbon and energy footprints, mostly due to the manufacturing of packaging materials and cardboard boxes, followed by the transportation of supplies. Regarding the water footprint, the agricultural phase was identified as the most significant contributor to water consumption, primarily attributed to maintenance operations and the application of agrochemicals. Full article

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