BRAF mutations are rare in myeloid neoplasms and are reported to be associated with poor treatment outcomes. The purpose of our study is to characterize BRAF mutations in myeloid neoplasms using a next-generation sequencing (NGS) panel based on the experiences of a single cancer center. We conducted a retrospective review of patients with myeloid neoplasms who underwent the HopeSeq studies between January 2018 and September 2023. A total of 14 patients with myeloid neoplasms carrying BRAF mutations were included in our cohort. The clinical, pathological, and molecular features of these patients were investigated. Our study indicates that BRAF mutations are rare in myeloid neoplasms, constituting only 0.53% (14/2632) of all myeloid neoplasm cases, with the most common BRAF mutation being BRAF V600E (4/14; 28.6%). Interestingly, we observed that six out of seven patients with acute myeloid leukemia (AML) exhibited AML with monocytic differentiation, and all the patients with AML exhibited an extremely poor prognosis compared to those without BRAF mutations. TET2 (5/14; 35.7%), ASXL1 (4/14; 28.6%), and JAK2 (4/14; 28.6%) were the three most frequently co-mutated genes in these patients. Moreover, we noted concurrent KMT2A gene rearrangement with BRAF mutations in three patients with AML (3/7; 42.9%). Our study suggests that although BRAF mutations are rare in myeloid neoplasms, they play a crucial role in the pathogenesis of specific AML subtypes. Furthermore, RAS pathway alterations, including BRAF mutations, are associated with KMT2A gene rearrangement in AML. However, these findings warrant further validation in larger studies. Full article

Background/Objectives: We used data from the Registry of Specialized Care Activity-Basic Minimum Data Set (RAE-CMBD) to select patients aged ≥40 years with COPD in Spain (2016-2021). We stratified the study population according to AF presence and sex. The propensity score matching (PSM) methodology was employed to create comparable groups based on age, admission year, and comorbidities at the time of hospitalization. Results: We identified 399,196 hospitalizations that met the inclusion criteria. Among them, 20.58% had AF. The prevalence of AF rose from 2016 to 2021 (18.26% to 20.95%), though the increase was only significant in men. The median length of hospital stay (LOHS) and IHM were significantly higher in patients with AF than in those without AF. After PSM, IHM remained significantly higher for man and women with AF. Older age, male sex, and several comorbidities were factors associated with AF. Additionally, older age, male sex, different comorbidities including COVID-19, hospitalization in the year 2020, mechanical ventilation, and intensive care unit (ICU) admission were associated with higher IHM in patients with AE-COPD and AF. Conclusions: AF prevalence was high in patients hospitalized for AE-COPD, was higher in men than in women, and increased over time. AF presence was associated with worse outcomes. The variables associated with IHM in hospitalized AE-COPD patients with AF were older age, male sex, different comorbidities including COVID-19 presence, hospitalization in the year 2020, need of mechanical ventilation, and ICU admission. Full article

Aphis gossypii Glover is an important pest in cotton plantations. Medicago sativa L. (alfalfa) is a host plant for the aphid Aphis craccivora Koch and may prove to be an important reservoir of natural enemies to combat this pest. The objective of this study was to analyze the impact of different mowing frequencies of alfalfa traps on A. gossypii and their natural enemies, using both ground survey data and UAV remote sensing data. The alfalfa was mowed twice to facilitate the transfer of this primary natural enemy to the cotton fields. Ground surveys were carried out every five days to gather data, while temporal niche and niche overlap methods were used for further analysis. Findings collected over a period ranging from day 31 to day 91 indicated that compared to their counterparts with no alfalfa traps, the cotton fields containing these pest control measures demonstrated a reduction in the A. gossypii population of approximately 16%. A survey conducted 5 days after mowing the alfalfa on days 61 and 71 found that the cotton fields with alfalfa traps experienced a 24.14% and 26.09% reduction in A. gossypii numbers. In contrast, the cotton fields without alfalfa traps experienced a 76.92% and 55.08% increase in cotton aphid numbers during the same period. It is noteworthy that the cotton fields with alfalfa traps showed a delayed onset of cotton aphid damage of approximately 5 days compared to the fields without alfalfa traps. This discovery has significant implications for understanding the ecological control mechanism of A. gossypii within alfalfa traps. Planting alfalfa traps around fields in Xinjiang could be promoted as a method to prevent and control aphid damage. Full article

Background/Objectives: Both hypertension and carotid atherosclerosis are independent risk factors for cardiovascular disease. We aim to investigate the synergistic effects of hypertension and carotid plaques on cardiovascular events and all-cause mortality. Methods: A follow-up study was conducted at the Preventive Cardiology Department of Vilnius University Hospital Santaros Klinikos between 2012 and 2021. The study recruited participants aged 40–65 who did not have overt cardiovascular disease (CVD) and were part of the Lithuanian High Cardiovascular Risk primary preventive program. The study collected demographic and clinical data, including an ultrasound assessment of carotid plaque. Results: The participants were monitored for 4–10 years for CVD events and all-cause mortality. Among 6138 participants, 954 (16%) experienced CVD events. The presence of carotid plaque on both sides was significantly associated with CVD events, myocardial infarction, and all-cause mortality. However, the combination of hypertension and carotid plaque did not significantly increase the risk for CVD events or all-cause mortality. Conclusions: The risk of CVD events or all-cause mortality was not significantly increased by the combination of hypertension and carotid plaque. Cardiovascular events depend on the extent of atherosclerosis in the carotid arteries. Full article

This paper details the design, development, and evaluation of VulcanH, a computerized maintenance management system (CMMS) specialized in preventive maintenance (PM) and predictive maintenance (PdM) management for underground mobile mining equipment. Further, it aims to expand knowledge on trust in automation (TiA) for PdM as well as contribute to the literature on explainability requirements of a PdM-capable artificial intelligence (AI). This study adopted an empirical approach through the execution of user tests with nine maintenance experts from five East-Canadian mines and implemented the User Experience Questionnaire Plus (UEQ+) and the Reliance Intentions Scale (RIS) to evaluate usability and TiA, respectively. It was found that the usability and efficiency of VulcanH were satisfactory for expert users and encouraged the gradual transition from PM to PdM practices. Quantitative and qualitative results documented participants’ willingness to rely on PdM predictions as long as suitable explanations are provided. Graphical explanations covering the full spectrum of the derived data were preferred. Due to the prototypical nature of VulcanH, certain relevant aspects of maintenance planning were not considered. Researchers are encouraged to include these notions in the evaluation of future CMMS proposals. This paper suggests a harmonious integration of both preventive and predictive maintenance practices in the mining industry. It may also guide future research in PdM to select an analytical algorithm capable of supplying adequate and causal justifications for informed decision making. This study fulfills an identified need to adopt a user-centered approach in the development of CMMSs in the mining industry. Hence, both researchers and industry stakeholders may benefit from the findings. Full article

The escalating energy consumption seen in the BRICS countries, namely Brazil, Russia, India, China, and South Africa, presents a substantial environmental problem, resulting in the depletion of resources, amplified carbon emissions, and endangering the well-being of ecological systems. The study examines the potential of green innovation to alleviate these adverse effects. By combining green technology with strong institutions and responsible energy consumption, we argue that the BRICS nations can significantly reduce their ecological footprint. This research, encompassing data from 1995 to 2022, employs Driscoll–Kraay and panel quantile regression to analyze the complex interplay of institutional quality, energy consumption, green innovation, and ecological footprints across the BRICS countries. Our findings reveal that green innovation is crucial in mitigating the ecological footprint, particularly when combined with resilient institutional quality and controlled energy use. Conversely, factors like high energy consumption, natural resource rent, and urbanization contribute to an increased ecological footprint. Notably, the study emphasizes the critical role of both institutional quality and renewable energy consumption in effectively reducing the ecological burden within the BRICS nations. These findings suggest that prioritizing investments in green technology and institutional development, even amidst high energy demands, represents a viable strategy for the BRICS nations to achieve sustainable growth and environmental responsibility. Full article

Smart grids integrate information technology, decision support systems, communication networks, and sensing technologies. All these components cooperate to facilitate dynamic power adjustments based on received client consumption reports. Although this brings forth energy efficiency, the transmission of sensitive data over the public internet exposes these networks to numerous attacks. To this end, numerous security solutions have been presented recently. Most of these techniques deploy conventional cryptographic systems such as public key infrastructure, blockchains, and physically unclonable functions that have either performance or security issues. In this paper, a fairly efficient authentication scheme is developed and analyzed. Its formal security analysis is carried out using the Burrows–Abadi–Needham (BAN) logic, which shows that the session key negotiated is provably secure. We also execute a semantic security analysis of this protocol to demonstrate that it can resist typical smart grid attacks such as privileged insider, guessing, eavesdropping, and ephemeral secret leakages. Moreover, it has the lowest amount of computation costs and relatively lower communication overheads as well as storage costs. Full article

The effect of amphiphilic block copolymer polyethylene glycol (PEG)-polypropylene glycol (PPG)-PEG concentration in the polyphenylsulfone (PPSU) casting solution and coagulation bath temperature (CBT) on the structure, separation, and antifouling performance of PPSU ultrafiltration membranes was studied for the first time. According to the phase diagram obtained, PPSU/PEG-PPG-PEG/N-methyl-2-pyrrolidone (NMP) systems are characterized by a narrow miscibility gap. It was found that 20 wt. % PPSU solutions in NMP with the addition of 5–15 wt. % of PEG-PPG-PEG block copolymer feature upper critical solution temperature, gel point, and lower critical solution temperature. Membrane composition and structure were studied by Fourier-transform infrared spectroscopy, scanning electron and atomic force microscopies, and water contact angle measurements. The addition of PEG-PPG-PPG to the PPSU casting solution was found to increase the hydrophilicity of the membrane surface (water contact angle decreased from 78° for the reference PPSU membrane down to 50° for 20 wt. %PPSU/15 wt. % PEG-PPG-PEG membrane). It was revealed that the pure water flux increased with the rise of CBT from 18–20 L·m⁻²·h⁻¹ for the reference PPSU membrane up to 38–140 L·m⁻²·h⁻¹ for 20 wt. % PPSU/10–15 wt. % PEG-PPG-PEG membranes. However, the opposite trend was observed for 20 wt. % PPSU/5–7 wt. % PEG-PPG-PEG membranes: pure water flux decreased with an increase in CBT. This is due to the differences in the mechanism of phase separation (non-solvent-induced phase separation (NIPS) or a combination of NIPS and temperature-induced phase separation (TIPS)). It was shown that 20 wt. % PPSU/10 wt. % PEG-PPG-PEG membranes were characterized by significantly higher antifouling performance (FRR—81–89%, DR_r—26–32%, DR_ir—10–20%, DT—33–45%) during the ultrafiltration of bovine serum albumin solutions compared to the reference PPSU membrane prepared at different CBTs (FRR—29–38%, DR_r—6–14%, DR_ir—74–89%, DT—88–94%). Full article

The authors present changes in the content and teaching methods of religious education (RE) in the third decade of the 21st century, as proposed by the current curricular reform of compulsory education in Slovakia. First, they analyse the reform documents in terms of social competence development as one of the RE content requirements. Second, they seek a teaching methodology that applies a balanced approach to the use of information and communication technologies (ICT) while protecting RE pupils and their building of healthy human relationships from the potential threat of digital addiction. The authors based their teaching ideas on the findings from their research. To explore the relationship between addictive Internet behaviour and social intelligence, they used a questionnaire including the Internet Addiction Test and the TSIS Scale. The Mann–Whitney U test was used for statistical analysis. Data on 386 adolescent respondents revealed a statistically significant difference between males and females in social awareness, with males performing significantly better. A weak positive relationship (ρ = 0.240) was identified between social awareness and addictive Internet behaviour. In the discussion, the authors suggest teaching methods for developing social competence via RE without resisting the opportunities provided by ICT, while also avoiding an increase in the risk of online social media addiction. They suggest that even denominational RE should prioritize cultivating healthy relationships not only with God but also relationships with other people, the outside world, and oneself. Full article

Snakebite accidents, neglected tropical diseases per the WHO, pose a significant public health threat due to their severity and frequency. Envenomation by Bothrops genus snakes leads to severe manifestations due to proteolytic enzymes. While the antibothropic serum produced by the Butantan Institute saves lives, its efficacy is limited as it fails to neutralize certain serine proteases. Hence, developing new-generation antivenoms, like monoclonal antibodies, is crucial. This study aimed to explore the inhibitory potential of synthetic peptides homologous to the CDR3 regions of a monoclonal antibody targeting a snake venom thrombin-like enzyme (SVTLE) from B. atrox venom. Five synthetic peptides were studied, all stable against hydrolysis by venoms and serine proteases. Impressively, four peptides demonstrated uncompetitive SVTLE inhibition, with Ki values ranging from 10⁻⁶ to 10⁻⁷ M. These findings underscore the potential of short peptides homologous to CDR3 regions in blocking snake venom toxins, suggesting their promise as the basis for new-generation antivenoms. Thus, this study offers potential advancements in combatting snakebites, addressing a critical public health challenge in tropical and subtropical regions. Full article

Pure lanthanum hexaboride (LaB₆) ceramics were prepared using powders of different grain sizes. The ceramics could reach a relative density of 98.2% at high temperatures and pressures, but had a low flexural strength (136.9 MPa). LaB₆ ceramics were synthesized using ZrO₂-Al₂O₃-TiO₂ (ZAT) as sintering additives. The ceramics demonstrate high density and excellent mechanical properties. The hot pressure sintering (HPS) method was utilized in the synthesis of the ceramics. Investigations were conducted on the effects of ZAT content, as well as the effects of the sintering temperature and pressure on the sintering behavior, microstructure, and mechanical and electrical properties of LaB₆ ceramics. LaB₆ ceramics fabricated with a ZAT addition of 6 wt.%, at a sintering temperature of 1700 °C, and under a pressure of 50 MPa, exhibited superior sintering and electrical properties, including a relative density of 97%, a conductivity of 7.2 MS/m, a flexural strength of 281.5 MPa, and a Vickers hardness of 21.2 GPa. The LaB₆ ceramics synthesized in this research exhibit promising potential as electron-emitting cathodes for field emission applications. Full article

This review article addresses the antioxidant properties of different natural products, including ascorbic acid, gallic acid, oxalic acid, L-glutathione (GSH), bacteriorhodopsin, green tea polyphenols, glucose, hydroxycinnamic acid, ethanoic acid, betanin, and L-glutathione, in the reduction of graphene oxide (rGO). rGO can cause damage to cells, including oxidative stress and inflammation, limiting its application in different sectors that use graphene, such as technologies used in medicine and dentistry. The natural substances reviewed have properties that help reduce this damage, neutralizing free radicals and maintaining cellular integrity. This survey demonstrates that the combination of these antioxidant compounds can be an effective strategy to minimize the harmful effects of rGO and promote cellular health. Full article

This paper proposes a nonlinear teaching approach, based on learning theories in cognitive psychology, with a special focus on large-cohort economics modules. The fundamental rationale is to match the features of teaching with the nature of learning. This approach was implemented in an undergraduate economics module, which received qualitative feedback and quantitative evaluation. Formal econometric models with both binary and continuous treatment effects were developed and estimated to quantify the effects of the proposed approach. Evidence shows that the nonlinear teaching approach significantly improves the effectiveness and efficiency of the learning-teaching process but does not promote student attendance. Full article

To enhance the precision and efficiency of the tractor-failure-rate and equipment-quality inspection, the present study introduces a wireless rapid detection method for assessing tractor quality. For this study, which was based on the symmetrical structural characteristics of tractors, we designed a magnetic suction accelerometer. The test system was composed of a wireless router, a magnetic suction accelerometer sensor, a data-acquisition terminal, and other components. This test system aimed to test the equipment quality of the tractor at idle speed before leaving the factory. The experiment found that the vibration characteristics of the tractor had a symmetrical pattern on the left and right sides of the front and rear axle at idle. When the idle speed of the tractor was 800 r/min and 1000 r/min, the predominant vibration direction of both sides of the front axle of the tractor was the Y direction, while the predominant vibration direction of the rear axle was the Z direction. The experimental results showed that the proposed wireless rapid detection method of tractor quality and the designed acceleration sensor had good testing accuracy. The present study could provide a novel rapid detection method for the failure detection of power machinery in the agricultural field and for inspection before leaving the factory. The implementation of the method could improve the detection efficiency, and reduce the detection cost and the incidence of failure during actual use. Full article

In the digital age, maintaining election integrity is critical, especially in Africa, where the security of electronic elections is often questioned. This study presents a blockchain-based vote counting and validation (BBVV) system developed using a mixed methods approach that combines stakeholder questionnaires to capture system specification and randomized historical election data analysis, following the Design Science Research strategy. Using the theory of the Byzantine General Problem, the BBVV protocol is proposed, which provides an accurate local count of votes at polling stations before national aggregation. The system was tested with randomized historical election data on the Algorand blockchain TestNet and confirmed that a local consensus on the vote count could be reached before it is added to the national tally on the blockchain. Our results show that in the cases where consensus was reached, this was the instance in only about 5% of the voting scenarios, with only 10% of the total vote being considered valid due to the strict consensus requirements. In addition, significant discrepancies were found between officials, with no consensus reached in 95% of cases which was due to the rogue values generated by a randomized dataset. The performance of the BBVV system was evaluated using transaction metrics, saturation, throughput, traffic, and latency to assess its efficiency, scalability, and reliability. The results suggest that blockchain technology can significantly improve the integrity of elections by ensuring a transparent, secure, and accurate vote-counting process. Future work will focus on improving the adaptability and scalability of the BBVV system for different electoral situations. Full article

(1) Background: Early interventions may effectively reduce the risk of mental disorders in individuals with ultra-high risk. Specifying the health needs of individuals with ultra-high risk is crucial before the implementation of successful early intervention. This study aimed to explore the differences in lifestyles, mental risks, and physical indices among individuals with ultra-high risk, patients with schizophrenia, and healthy subjects. (2) Methods: A cross-section design applying seven questionnaires with physical examinations for 144 participants aged 13–45 years old was conducted in this study. The questionnaires included one about personal data, four on mental risks, and two for lifestyles. (3) Results: The individuals with ultra-high risk scored similarly in many dimensions as the patients with schizophrenia, but they displayed lower positive symptoms, lower negative symptoms, lower prodromal symptoms, higher interpersonal deficits, lower nutrition intake, and higher levels of exercise than the patients with schizophrenia. Female individuals with ultra-high risk had lower self-esteem, higher positive symptoms, lower nutrition intake, and higher exercise levels than male ones. (4) Conclusions: The study pinpointed specific health needs with interpersonal deficits, nutrition intake, and physical activity for the individuals with ultra-high risk. Future interventions targeted on improving social function, dietary pattern, and exercise will be beneficial. Full article

The electrocatalytic nitrogen reduction reaction (NRR) for synthesizing ammonia holds promise as an alternative to the traditional high-energy-consuming Haber–Bosch method. Rational and accurate catalyst design is needed to overcome the challenge of activating N₂ and to suppress the competitive hydrogen evolution reaction (HER). Single-atom catalysts have garnered widespread attention due to their 100% atom utilization efficiency and unique catalytic performance. In this context, we constructed theoretical models of metal single-atom catalysts supported on titanate nanosheets (M-TiNS). Initially, density functional theory (DFT) was employed to screen 12 single-atom catalysts for NRR- and HER-related barriers, leading to the identification of the theoretically optimal NRR catalyst, Ru-TiNS. Subsequently, experimental synthesis of the Ru-TiNS single-atom catalyst was successfully achieved, exhibiting excellent performance in catalyzing NRR, with the highest NH₃ yield rate reaching 15.19 μmol mg_cat⁻¹ h⁻¹ and a Faradaic efficiency (FE) of 15.3%. The combination of experimental results and theoretical calculations demonstrated the efficient catalytic ability of Ru sites, validating the effectiveness of the constructed theoretical screening process and providing a theoretical foundation for the design of efficient NRR catalysts. Full article

Pradofloxacin—a dual-targeting fluoroquinolone—is the most recent approved for use in food animals. Minimum inhibitory and mutant prevention concentration values were determined for pradofloxacin, ceftiofur, enrofloxacin, florfenicol, marbofloxacin, tildipirosin, tilmicosin, and tulathromycin. For M. haemolytica strains, MIC_50/90/100 values were ≤0.016/≤0.016/≤0.016 and MPC_50/90/100 values were 0.031/0.063/0.063; for P. multocida strains, the MIC_50/90/100 values ≤0.016/≤0.016/0.031 and MPC_50/90/100 ≤ 0.016/0.031/0.063 for pradofloxacin. The pradofloxacin C_max/MIC₉₀ and C_max/MPC₉₀ values for M. haemolytica and P. multocida strains, respectively, were 212.5 and 53.9 and 212.5 and 109.7. Similarly, AUC₂₄/MIC₉₀ and AUC₂₄/MPC₉₀ for M. haemolytica were 825 and 209.5, and for P. multocida, they were 825 and 425.8. Pradofloxacin would exceed the mutant selection window for >12–16 h. Pradofloxacin appears to have a low likelihood for resistance selection against key bovine respiratory disease bacterial pathogens based on low MIC and MPC values. Full article

The whole trusteeship of green agricultural production plays an important role in promoting the protection of black land, and it is particularly crucial to clarify the behavioral characteristics and game relationships of agents involved in the whole trusteeship. This study uses the dynamic evolutionary game method to construct a tripartite evolutionary game model of governments, service organizations and farmers participating in the whole trusteeship of green agricultural production, aiming to come up with effective strategies to promote the widespread application of green agricultural production trusteeship and achieve agricultural green development. The results are as follows: (1) At present, the agricultural production model in Northeast China is dominated by traditional agricultural production and supplemented by green agricultural production. (2) Incentive and punitive measures will encourage agents to adopt positive strategies. (3) In areas with a poor awareness of green agricultural production trusteeship, the government’s incentive and punishment measures for farmers and service organizations are imbalanced. (4) The relatively high cost of trusteeship leads to a lack of market competitiveness, which has a negative impact on service organizations promoting green agricultural production trusteeship. This study provides an effective reference for improving the overall implementation effect of black land protection in Northeast China. Full article

This paper proposes a novel soft sensor modeling approach, MIC-TCA-INGO-LSSVM, to address the decline in performance of soft sensor models during the fermentation process of Pichia pastoris, caused by changes in working conditions. Initially, the transfer component analysis (TCA) method is utilized to minimize the differences in data distribution across various working conditions. Subsequently, a least squares support vector machine (LSSVM) model is constructed using the dataset adapted by TCA, and strategies for improving the northern goshawk optimization (INGO) algorithm are proposed to optimize the parameters of the LSSVM model. Finally, to further enhance the model’s generalization ability and prediction accuracy, considering the transfer of knowledge from multiple-source working conditions, a sub-model weighted ensemble scheme is proposed based on the maximum information coefficient (MIC) algorithm. The proposed soft sensor model is employed to predict cell and product concentrations during the fermentation process of Pichia pastoris. Simulation results indicate that the RMSE of the INGO-LSSVM model in predicting cell and product concentrations is reduced by 47.3% and 42.1%, respectively, compared to the NGO-LSSVM model. Additionally, TCA significantly enhances the model’s adaptability when working conditions change. Moreover, the soft sensor model based on TCA and the MIC-weighted ensemble method achieves a reduction of 41.6% and 31.3% in the RMSE for predicting cell and product concentrations, respectively, compared to the single-source condition transfer model TCA-INGO-LSSVM. These results demonstrate the high reliability and predictive performance of the proposed soft sensor method under varying working conditions. Full article

A non-structural SARS-CoV-2 protein, PLpro, is involved in post-translational modifications in cells, allowing the evasion of antiviral immune response mechanisms. In this study, potential PLpro inhibitory drugs were designed using QSAR, molecular docking, and molecular dynamics. A combined QSAR equation with physicochemical and Free-Wilson descriptors was formulated. The r², q², and r²_test values were 0.833, 0.770, and 0.721, respectively. From the equation, it was found that the presence of an aromatic ring and a basic nitrogen atom is crucial for obtaining good antiviral activity. Then, a series of structures for the binding sites of C111, Y268, and H73 of PLpro were created. The best compounds were found to exhibit pIC₅₀ values of 9.124 and docking scoring values of −14 kcal/mol. The stability of the compounds in the cavities was confirmed by molecular dynamics studies. A high number of stable contacts and good interactions over time were exhibited by the aryl-thiophenes Pred14 and Pred15, making them potential antiviral candidates. Full article

This study aims to evaluate several defined specimen parameters that would allow to determine the surgical accuracy of breast-conserving surgeries (BCS) in a representative population of patients. These specimen parameters could be used to compare surgical accuracy when using novel technologies for intra-operative BCS guidance in the future. Different specimen parameters were determined among 100 BCS patients, including the ratio of specimen volume to tumor volume (resection ratio) with different optimal margin widths (0 mm, 1 mm, 2 mm, and 10 mm). Furthermore, the tumor eccentricity [maximum tumor-margin distance − minimum tumor-margin distance] and the relative tumor eccentricity [tumor eccentricity ÷ pathological tumor diameter] were determined. Different patient subgroups were compared using Wilcoxon rank sum tests. When using a surgical margin width of 0 mm, 1 mm, 2 mm, and 10 mm, on average, 19.16 (IQR 44.36), 9.94 (IQR 18.09), 6.06 (IQR 9.69) and 1.35 (IQR 1.78) times the ideal resection volume was excised, respectively. The median tumor eccentricity among the entire patient population was 11.29 mm (SD = 3.99) and the median relative tumor eccentricity was 0.66 (SD = 2.22). Resection ratios based on different optimal margin widths (0 mm, 1 mm, 2 mm, and 10 mm) and the (relative) tumor eccentricity could be valuable outcome measures to evaluate the surgical accuracy of novel technologies for intra-operative BCS guidance. Full article