The 2023 MDPI Annual Report has
been released!
 
8 pages, 377 KiB  
Article
Impact and Occurrence of Herpesvirus and Aspergillosis Superinfection in Patients with Severe COVID-19 Pneumonia
by Antoinette D. Reichert, Júlia M. da Silva Voorham, Karin H. Groenewegen and Huub La van den Oever
COVID 2024, 4(5), 637-644; https://doi.org/10.3390/covid4050042 (registering DOI) - 13 May 2024
Abstract
Background: Pulmonary superinfections with Herpesviridae and Aspergillus spp. are common in severe coronavirus disease 2019 (COVID-19) pneumonia but their epidemiology and impact remain poorly understood. Methods: We conducted a retrospective observational study of 61 mechanically ventilated COVID-19 patients at Deventer Hospital’s ICU (2020–2021) [...] Read more.
Background: Pulmonary superinfections with Herpesviridae and Aspergillus spp. are common in severe coronavirus disease 2019 (COVID-19) pneumonia but their epidemiology and impact remain poorly understood. Methods: We conducted a retrospective observational study of 61 mechanically ventilated COVID-19 patients at Deventer Hospital’s ICU (2020–2021) who underwent bronchoalveolar lavage (BL) due to clinical deterioration. We analyzed blood and respiratory samples, treatment, and clinical outcomes. Results: Among 61 mechanically ventilated COVID-19 patients who underwent BL, 34 (55.7%) had superinfections, with 18 having COVID-19-associated pulmonary aspergillosis (CAPA), 7 having herpes simplex virus (HSV) infection, and 9 having both. Patients with HSV had later diagnoses (median 14 vs. 8 days, p = 0.014), longer mechanical ventilation (median 47 vs. 18.5 days, p = 0.015), and longer ICU stays (median 74 vs. 24 days, p = 0.021) compared to CAPA patients. At baseline, laboratory parameters and treatment (dexamethasone or tocilizumab) showed no significant association with superinfections. Mortality did not differ significantly among groups. Conclusion: In mechanically ventilated COVID-19 patients undergoing bronchoalveolar lavage, HSV reactivation occurred later in the course of illness and was associated with longer mechanical ventilation and ICU stays compared to CAPA. Baseline parameters did not predict superinfections. Full article
Show Figures

Figure 1

28 pages, 13737 KiB  
Article
Emergence of Novel WEDEx-Kerberotic Cryptographic Framework to Strengthen the Cloud Data Security against Malicious Attacks
by Syeda Wajiha Zahra, Muhammad Nadeem, Ali Arshad, Saman Riaz, Waqas Ahmed, Muhammad Abu Bakr and Amerah Alabrah
Symmetry 2024, 16(5), 605; https://doi.org/10.3390/sym16050605 (registering DOI) - 13 May 2024
Abstract
Researchers have created cryptography algorithms that encrypt data using a public or private key to secure it from intruders. It is insufficient to protect the data by using such a key. No research article has identified an algorithm capable of protecting both the [...] Read more.
Researchers have created cryptography algorithms that encrypt data using a public or private key to secure it from intruders. It is insufficient to protect the data by using such a key. No research article has identified an algorithm capable of protecting both the data and the associated key, nor has any mechanism been developed to determine whether access to the data is permissible or impermissible based on the authentication of the key. This paper presents a WEDEx-Kerberotic Framework for data protection, in which a user-defined key is firstly converted to a cipher key using the “Secure Words on Joining Key (SWJK)” algorithm. Subsequently, a WEDEx-Kerberotic encryption mechanism is created to protect the data by encrypting it with the cipher key. The first reason for making the WEDEx-Kerberotic Framework is to convert the user-defined key into a key that has nothing to do with the original key, and the length of the cipher key is much shorter than the original key. The second reason is that each ciphertext and key value are interlinked. When an intruder utilizes the snatching mechanism to obtain data, the attacker obtains data or a key unrelated to the original data. No matter how efficient the algorithm is, an attacker cannot access the data when these methods and algorithms are used to protect it. Finally, the proposed algorithm is compared to the previous approaches to determine the uniqueness of the algorithm and assess its superiority to the previous algorithms. Full article
(This article belongs to the Section Computer)
Show Figures

Figure 1

15 pages, 1807 KiB  
Article
Surface Bubbles Emergence as an Indicator for Optimal Concrete Compaction
by Hassan Ahmed and Jouni Punkki
Materials 2024, 17(10), 2306; https://doi.org/10.3390/ma17102306 (registering DOI) - 13 May 2024
Abstract
Compaction quality significantly influences the strength and durability of concrete in structures. Under-compacting can retain entrapped air, reducing strength, while over-compacting can lead to segregation, creating local variances in strength distribution and modulus of elasticity in the concrete structure. This study examines the [...] Read more.
Compaction quality significantly influences the strength and durability of concrete in structures. Under-compacting can retain entrapped air, reducing strength, while over-compacting can lead to segregation, creating local variances in strength distribution and modulus of elasticity in the concrete structure. This study examines the widely adopted concept that compaction is optimal when bubbles cease to emerge on the concrete surface. We recorded the surface activity of six comparable concrete specimens during the compaction process using a 4K video camera. Four specimens were compacted using a table vibrator and two with a poker vibrator. From the video frames, we isolated the bubbles for analysis, employing digital image processing techniques to distinguish newly risen bubbles per frame. It was found that the bubbles continuously rose to the surface in all specimens throughout the compaction process, suggesting a need for extended compaction, with some specimens showing a slow in the rate of the bubbles’ emergence. However, upon examining the segregation levels, it was discovered that all the specimens were segregated, some severely, despite the continued bubble emergence. These findings undermine the reliability of using bubble emergence as a principle to stop compaction and support the need for developing online measurement tools for evaluating compaction quality. Full article
(This article belongs to the Section Construction and Building Materials)
28 pages, 5233 KiB  
Article
Machine Learning Algorithms That Emulate Controllers Based on Particle Swarm Optimization—An Application to a Photobioreactor for Algal Growth
by Viorel Mînzu, Iulian Arama and Eugen Rusu
Processes 2024, 12(5), 991; https://doi.org/10.3390/pr12050991 (registering DOI) - 13 May 2024
Abstract
Particle Swarm Optimization (PSO) algorithms within control structures are a realistic approach; their task is often to predict the optimal control values working with a process model (PM). Owing to numerous numerical integrations of the PM, there is a big computational effort that [...] Read more.
Particle Swarm Optimization (PSO) algorithms within control structures are a realistic approach; their task is often to predict the optimal control values working with a process model (PM). Owing to numerous numerical integrations of the PM, there is a big computational effort that leads to a large controller execution time. The main motivation of this work is to decrease the computational effort and, consequently, the controller execution time. This paper proposes to replace the PSO predictor with a machine learning model that has “learned” the quasi-optimal behavior of the couple (PSO and PM); the training data are obtained through closed-loop simulations over the control horizon. The new controller should preserve the process’s quasi-optimal control. In identical conditions, the process evolutions must also be quasi-optimal. The multiple linear regression and the regression neural networks were considered the predicting models. This paper first proposes algorithms for collecting and aggregating data sets for the learning process. Algorithms for constructing the machine learning models and implementing the controllers and closed-loop simulations are also proposed. The simulations prove that the two machine learning predictors have learned the PSO predictor’s behavior, such that the process evolves almost identically. The resulting controllers’ execution time have decreased hundreds of times while keeping their optimality; the performance index has even slightly increased. Full article
Show Figures

Figure 1

18 pages, 1370 KiB  
Article
A Sparse Recovery Algorithm for Suppressing Multiple Linear Frequency Modulation Interference in the Synthetic Aperture Radar Image Domain
by Guanqi Tong, Xingyu Lu, Jianchao Yang, Wenchao Yu, Hong Gu and Weimin Su
Sensors 2024, 24(10), 3095; https://doi.org/10.3390/s24103095 (registering DOI) - 13 May 2024
Abstract
In synthetic aperture radar (SAR) signal processing, compared with the raw data of level-0, level-1 SAR images are more readily accessible and available in larger quantities. However, an amount of level-1 images are affected by radio frequency interference (RFI), which typically originates from [...] Read more.
In synthetic aperture radar (SAR) signal processing, compared with the raw data of level-0, level-1 SAR images are more readily accessible and available in larger quantities. However, an amount of level-1 images are affected by radio frequency interference (RFI), which typically originates from Linear Frequency Modulation (LFM) signals emitted by ground-based radars. Existing research on interference suppression in level-1 data has primarily focused on two methods: transforming SAR images into simulated echo data for interference suppression, or focusing interference in the frequency domain and applying notching filters to reduce interference energy. However, these methods overlook the effective utilization of the interference parameters or are confined to suppressing only one type of LFM interference at a time. In certain SAR images, multiple types of LFM interference manifest bright radiation artifacts that exhibit varying lengths along the range direction while remaining constant in the azimuth direction. It is necessary to suppress multiple LFM interference on SAR images when original echo data are unavailable. This article proposes a joint sparse recovery algorithm for interference suppression in the SAR image domain. In the SAR image domain, two-dimensional LFM interference typically exhibits differences in parameters such as frequency modulation rate and pulse width in the range direction, while maintaining consistency in the azimuth direction. Based on this observation, this article constructs a series of focusing operators for LFM interference in SAR images. These operators enable the sparse representation of dispersed LFM interference. Subsequently, an optimization model is developed that can effectively suppress multi-LFM interference and reduce image loss with the assistance of a regularization term in the image domain. Simulation experiments conducted in various scenarios validate the superior performance of the proposed method. Full article
(This article belongs to the Section Radar Sensors)
9 pages, 390 KiB  
Article
I am Afraid I Will Not Be Able to Walk, That is What Worries Me—The Experience of Patients with Knee Osteoarthritis before Total Knee Arthroplasty: A Qualitative Study
by Umile Giuseppe Longo, Alessandra Corradini, Anna Marchetti, Chiara Di Sarno, Carlotta D’Angelo, Claudia Arias, Maria Grazia De Marinis, Alessandro de Sire and Vincenzo Denaro
J. Clin. Med. 2024, 13(10), 2878; https://doi.org/10.3390/jcm13102878 (registering DOI) - 13 May 2024
Abstract
Knee osteoarthritis is the most prevalent type of osteoarthritis. Patients frequently encounter pain triggered by movement that evolves into impaired joint function. Needing persistent rest or having night-time pain signifies advanced disease. Qualitative research is considered the most effective method for comprehending patients’ [...] Read more.
Knee osteoarthritis is the most prevalent type of osteoarthritis. Patients frequently encounter pain triggered by movement that evolves into impaired joint function. Needing persistent rest or having night-time pain signifies advanced disease. Qualitative research is considered the most effective method for comprehending patients’ needs and contexts. Methods: This study employed a qualitative research design, allowing the researchers to acquire insights into the patients’ beliefs and values, and the contextual factors influencing the formation and expression of these beliefs and values. Results: A cohort of nine patients awaiting total knee replacement (TKR) surgery was included and they were interviewed until data saturation was achieved. The results of the phenomenological analysis resulted in the identification of three themes: “The existence of pain impedes the capacity to participate in daily life activities”; “TKR induced fears and uncertainties regarding the progression of the disease”; “Severe nighttime pain compromising sleep quality”. Conclusions: This study analyzes the experiences of people awaiting TKR surgery, emphasizing the importance of addressing their unique needs to improve preoperative education and rehabilitation. In this way, patients’ recovery during the postoperative phase can be improved. Full article
(This article belongs to the Section Orthopedics)
23 pages, 513 KiB  
Communication
The Paradox of Alcohol and Food Affordability: Minimal Impact of Leading Beer and Cachaça Brands on Brazilian Household Income Amid Hazardous Drinking Patterns
by Ian C. C. Nóbrega, Rhennan V. L. Marques, Matheus A. Ferreira and Dirk W. Lachenmeier
Nutrients 2024, 16(10), 1469; https://doi.org/10.3390/nu16101469 (registering DOI) - 13 May 2024
Abstract
Alcohol consumption, associated with various cancers, mental disorders, and aggressive behavior, leads to three million deaths globally each year. In Brazil, the alcohol per capita consumption among drinkers aged 15 and over is 41.7 g of pure alcohol/day (~1 L beer/day), which falls [...] Read more.
Alcohol consumption, associated with various cancers, mental disorders, and aggressive behavior, leads to three million deaths globally each year. In Brazil, the alcohol per capita consumption among drinkers aged 15 and over is 41.7 g of pure alcohol/day (~1 L beer/day), which falls into the risky consumption category and exceeds the global average by almost 30%. An effective way to mitigate alcohol-related harm is to increase its retail price. This study assesses the costs of consuming leading brands of beer and sugarcane spirit cachaça (Brazil’s most popular alcoholic beverages) against the expenditure on staple foods. Data on food and alcoholic beverage prices were collected in João Pessoa, Brazil, for 2020 and 2021. The cost per gram of pure alcohol and food were considered to establish consumption patterns of 16.8 g/day (moderate), 41.7 g/day, and 83.4 g/day (heavy), distributed in three scenarios involving the beverages alone or combined (64% beer and 36% cachaça), and a balanced 2000 kcal/day staple diet. The study finds that all heavy consumption scenarios cost less or significantly less (cachaça alone) than a 2000 kcal/day staple diet, highlighting an urgent need for fiscal policies, such as a minimum unit pricing for alcohol, to address public health concerns. Full article
(This article belongs to the Special Issue Public Health, Nutritional Behavior and Nutritional Status)
18 pages, 1370 KiB  
Article
Accelerated Ballast Tank Corrosion Simulation Protocols: A Critical Assessment
by Remke Willemen, Kris De Baere, Rob Baetens, Maarten Van Rossum and Silvia Lenaerts
Materials 2024, 17(10), 2304; https://doi.org/10.3390/ma17102304 (registering DOI) - 13 May 2024
Abstract
 In the realm of accelerated testing within controlled laboratory settings, the fidelity of the service environment assumes paramount importance. It is imperative to replicate real-world conditions while compressing the testing duration to facilitate early evaluations, thereby optimizing time and cost efficiencies. Traditional [...] Read more.
 In the realm of accelerated testing within controlled laboratory settings, the fidelity of the service environment assumes paramount importance. It is imperative to replicate real-world conditions while compressing the testing duration to facilitate early evaluations, thereby optimizing time and cost efficiencies. Traditional immersion protocols, reflective solely of full ballast tank conditions, inadequately expedite the corrosion process representative of an average ballast tank environment. Through the integration of immersion with fog/dry conditions, aligning the test protocol more closely with the internal conditions of an average ballast tank, heightened rates of general corrosion are achieved. This augmentation yields an acceleration factor of 7.82 times the standard test duration, under the assumption of a general corrosion rate of 0.4 mm/year for uncoated ballast tank steel, with both sides exposed. Subsequently, the fog/dry test protocol, albeit only resembling the environment of an empty ballast tank, closely trails in terms of acceleration efficacy. The fog/dry test protocol offers cost-effectiveness and replicability compared to the AMACORT CIFD-01 protocol, making it a strong competitor despite the relatively close acceleration factor. Full article
(This article belongs to the Section Corrosion)
16 pages, 370 KiB  
Article
Lower Limb Motion Recognition with Improved SVM Based on Surface Electromyography
by Pengjia Tu, Junhuai Li and Huaijun Wang
Sensors 2024, 24(10), 3097; https://doi.org/10.3390/s24103097 (registering DOI) - 13 May 2024
Abstract
During robot-assisted rehabilitation, failure to recognize lower limb movement may efficiently limit the development of exoskeleton robots, especially for individuals with knee pathology. A major challenge encountered with surface electromyography (sEMG) signals generated by lower limb movements is variability between subjects, such as [...] Read more.
During robot-assisted rehabilitation, failure to recognize lower limb movement may efficiently limit the development of exoskeleton robots, especially for individuals with knee pathology. A major challenge encountered with surface electromyography (sEMG) signals generated by lower limb movements is variability between subjects, such as motion patterns and muscle structure. To this end, this paper proposes an sEMG-based lower limb motion recognition using an improved support vector machine (SVM). Firstly, non-negative matrix factorization (NMF) is leveraged to analyze muscle synergy for multi-channel sEMG signals. Secondly, the multi-nonlinear sEMG features are extracted, which reflect the complexity of muscle status change during various lower limb movements. The Fisher discriminant function method is utilized to perform feature selection and reduce feature dimension. Then, a hybrid genetic algorithm-particle swarm optimization (GA-PSO) method is leveraged to determine the best parameters for SVM. Finally, the experiments are carried out to distinguish 11 healthy and 11 knee pathological subjects by performing three different lower limb movements. Results demonstrate the effectiveness and feasibility of the proposed approach in three different lower limb movements with an average accuracy of 96.03% in healthy subjects and 93.65% in knee pathological subjects, respectively. Full article
(This article belongs to the Section Biosensors)
Show Figures

Figure 1

17 pages, 912 KiB  
Article
Experimental Study on Calcination of Portland Cement Clinker Using Different Contents of Stainless Steel Slag
by Jiantao Ju, Haibo Cao, Wenke Guo, Ning Luo, Qiming Zhang and Yonggang Wang
Materials 2024, 17(10), 2305; https://doi.org/10.3390/ma17102305 (registering DOI) - 13 May 2024
Abstract
In order to increase the utilization rate of stainless steel slag, reduce storage needs, and mitigate environmental impacts, this study replaces a portion of limestone with varying amounts of stainless steel slag in the calcination of Portland cement clinker. The study primarily examines [...] Read more.
In order to increase the utilization rate of stainless steel slag, reduce storage needs, and mitigate environmental impacts, this study replaces a portion of limestone with varying amounts of stainless steel slag in the calcination of Portland cement clinker. The study primarily examines the influence of stainless steel slag on the phase composition, microstructure, compressive strength, and free calcium oxide (ƒ-CaO) content of Portland cement clinker. The results show the following: (1) Using stainless steel slag to calcine Portland cement clinker can lower the calcination temperature, reducing industrial production costs and energy consumption. (2) With an increase in the amount of stainless steel slag, the dicalcium silicate (C2S) and tricalcium silicate (C3S) phases in Portland cement clinker initially increase and then decrease; the C3S crystals gradually transform into continuous hexagonal plate-shaped distributions, while the tricalcium aluminate (C3A) and tetracalcium aluminoferrite (C4AF) crystal structures become denser. When the stainless steel slag content is 15%, the dicalcium silicate and tricalcium silicate phases are at their peak; the C3S crystals are continuously distributed with a relatively dense structure, and C3A and C4AF crystals melt and sinter together, becoming distributed around C3S. (3) As stainless steel slag content increases, the compressive strength of Portland cement clinker at 3 days, 7 days, and 28 days increases and then decreases, while ƒ-CaO content decreases and then increases. When the stainless steel slag content is 15%, the compressive strength at 28 days is at its highest, 64.4 MPa, with the lowest ƒ-CaO content, 0.78%. The test results provide a basis for the utilization of stainless steel slag in the calcination of Portland cement clinker. Full article
13 pages, 980 KiB  
Article
Antioxidant, Enzyme Inhibitory, and Protective Effect of Amelanchier lamarckii Extract
by Adela Maria Dăescu, Mădălina Nistor, Alexandru Nicolescu, Roxana Pop, Andrea Bunea, Dumitrita Rugina and Adela Pintea
Plants 2024, 13(10), 1347; https://doi.org/10.3390/plants13101347 (registering DOI) - 13 May 2024
Abstract
The present study aimed to investigate the chemical content of Romanian juneberries (Amelanchier lamarckii), their effect on antioxidant and enzyme inhibition activities, and their bioaccessibility after simulated in-vitro digestion. In Amelanchier lamarckii extract (AME), 16 polyphenolic compounds were identified by LC-ESI+-MS [...] Read more.
The present study aimed to investigate the chemical content of Romanian juneberries (Amelanchier lamarckii), their effect on antioxidant and enzyme inhibition activities, and their bioaccessibility after simulated in-vitro digestion. In Amelanchier lamarckii extract (AME), 16 polyphenolic compounds were identified by LC-ESI+-MS analysis. The most representative compounds found in the extract were cyanidin-galactoside, 3,4-dihydroxy-5-methoxybenzoic acid, feruloylquinic acid, and kaempferol, all belonging to the anthocyanins, phenolic acids, and flavonols subclasses. The polyphenols of AME exert quenching abilities of harmful reactive oxygen species, as the CUPRAC antioxidant assay value was 323.99 µmol Trolox/g fruit (FW), whereas the FRAP antioxidant value was 4.10 μmol Fe2+/g fruit (FW). Enzyme inhibition assays targeting tyrosinase (IC50 = 8.843 mg/mL), α-glucosidase (IC50 = 14.03 mg/mL), and acetylcholinesterase (IC50 = 49.55 mg/mL) were used for a screening of AME’s inhibitory potential against these key enzymes as a common approach for the discovery of potential antidiabetic, skin pigmentation, and neurodegenerative effects. The screening for the potential antidiabetic effects due to the α-glucosidase inhibition was performed in glucose-induced disease conditions in a human retinal pigmented epithelial cell experimental model, proving that AME could have protective potential. In conclusion, AME is a valuable source of phenolic compounds with promising antioxidant potential and metabolic disease-protective effects, warranting further investigation for its use in the nutraceutical and health industries. Full article
(This article belongs to the Special Issue Phytochemical Analysis and Metabolic Profiling in Plants)
Show Figures

Figure 1

15 pages, 1016 KiB  
Article
A Fast and Sensitive One-Tube SARS-CoV-2 Detection Platform Based on RTX-PCR and Pyrococcus furiosus Argonaute
by Rui Han, Fei Wang, Wanping Chen and Lixin Ma
Biosensors 2024, 14(5), 245; https://doi.org/10.3390/bios14050245 (registering DOI) - 13 May 2024
Abstract
Since SARS-CoV-2 is a highly transmissible virus, alternative reliable, fast, and cost-effective methods are still needed to prevent virus spread that can be applied in the laboratory and for point-of-care testing. Reverse transcription real-time fluorescence quantitative PCR (RT-qPCR) is currently the gold criteria [...] Read more.
Since SARS-CoV-2 is a highly transmissible virus, alternative reliable, fast, and cost-effective methods are still needed to prevent virus spread that can be applied in the laboratory and for point-of-care testing. Reverse transcription real-time fluorescence quantitative PCR (RT-qPCR) is currently the gold criteria for detecting RNA viruses, which requires reverse transcriptase to reverse transcribe viral RNA into cDNA, and fluorescence quantitative PCR detection was subsequently performed. The frequently used reverse transcriptase is thermolabile; the detection process is composed of two steps: the reverse transcription reaction at a relatively low temperature, and the qPCR performed at a relatively high temperature, moreover, the RNA to be detected needs to pretreated if they had advanced structure. Here, we develop a fast and sensitive one-tube SARS-CoV-2 detection platform based on Ultra-fast RTX-PCR and Pyrococcus furiosus Argonaute-mediated Nucleic acid Detection (PAND) technology (URPAND). URPAND was achieved ultra-fast RTX-PCR process based on a thermostable RTX (exo-) with both reverse transcriptase and DNA polymerase activity. The URPAND can be completed RT-PCR and PAND to detect nucleic acid in one tube within 30 min. This method can specifically detect SARS-CoV-2 with a low detection limit of 100 copies/mL. The diagnostic results of clinical samples with one-tube URPAND displayed 100% consistence with RT-qPCR test. Moreover, URPAND was also applied to identify SARS-CoV-2 D614G mutant due to its single-nucleotide specificity. The URPAND platform is rapid, accurate, tube closed, one-tube, easy-to-operate and free of large instruments, which provides a new strategy to the detection of SARS-CoV-2 and other RNA viruses. Full article
(This article belongs to the Special Issue Immunoassays and Biosensing)
25 pages, 13232 KiB  
Article
Onboard Data Prioritization Using Multi-Class Image Segmentation for Nanosatellites
by Keenan Chatar, Kentaro Kitamura and Mengu Cho
Remote Sens. 2024, 16(10), 1729; https://doi.org/10.3390/rs16101729 (registering DOI) - 13 May 2024
Abstract
Nanosatellites are proliferating as low-cost, dedicated remote sensing opportunities for small nations. However, nanosatellites’ performance as remote sensing platforms is impaired by low downlink speeds, which typically range from 1200 to 9600 bps. Additionally, an estimated 67% of downloaded data are unusable for [...] Read more.
Nanosatellites are proliferating as low-cost, dedicated remote sensing opportunities for small nations. However, nanosatellites’ performance as remote sensing platforms is impaired by low downlink speeds, which typically range from 1200 to 9600 bps. Additionally, an estimated 67% of downloaded data are unusable for further applications due to excess cloud cover. To alleviate this issue, we propose an image segmentation and prioritization algorithm to classify and segment the contents of captured images onboard the nanosatellite. This algorithm prioritizes images with clear captures of water bodies and vegetated areas with high downlink priority. This in-orbit organization of images will aid ground station operators with downlinking images suitable for further ground-based remote sensing analysis. The proposed algorithm uses Convolutional Neural Network (CNN) models to classify and segment captured image data. In this study, we compare various model architectures and backbone designs for segmentation and assess their performance. The models are trained on a dataset that simulates captured data from nanosatellites and transferred to the satellite hardware to conduct inferences. Ground testing for the satellite has achieved a peak Mean IoU of 75% and an F1 Score of 0.85 for multi-class segmentation. The proposed algorithm is expected to improve data budget downlink efficiency by up to 42% based on validation testing. Full article
14 pages, 3819 KiB  
Article
COVID-19 Lockdown Air Pollution Reduction: Did It Impact the Number of COPD Hospitalizations?
by Jovan Javorac, Dejan Živanović, Miroslav Ilić, Vesna Mijatović Jovin, Svetlana Stojkov, Mirjana Smuđa, Ivana Minaković, Bela Kolarš, Veljko Ćućuz and Marija Jevtić
Atmosphere 2024, 15(5), 593; https://doi.org/10.3390/atmos15050593 (registering DOI) - 13 May 2024
Abstract
In addition to the detrimental health consequences, the early stages of the COVID-19 pandemic have yielded unforeseen benefits in terms of reducing air pollution emissions. This study investigated air pollution changes in Novi Sad, Serbia, during the COVID-19 lockdown (March–June 2020) and their [...] Read more.
In addition to the detrimental health consequences, the early stages of the COVID-19 pandemic have yielded unforeseen benefits in terms of reducing air pollution emissions. This study investigated air pollution changes in Novi Sad, Serbia, during the COVID-19 lockdown (March–June 2020) and their correlation with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) hospitalizations. Using quasi-Poisson generalized linear models (GLM) and distributed lag non-linear models (DLNM), we examined the relationship between the number of AECOPD hospitalizations and the concentrations of selected air pollutants (PM10, PM2.5, SO2, and NO2) from March to June of 2019, 2020, and 2021. During the COVID-19 lockdown, significant reductions in most air pollutant concentrations and the number of AECOPD hospitalizations were observed. However, neither the study year nor its interaction with air pollutant concentration significantly predicted AECOPD hospitalizations (p > 0.05). The 95% confidence intervals of the relative risks for the occurrence of AECOPD hospitalizations at each increase in the examined air pollutant by 10 μg/m3 overlapped across years, suggesting consistent effects of air pollution on the risk of AECOPD hospitalizations pre-pandemic and during lockdown. In conclusion, reduced air pollution emissions during the COVID-19 lockdown did not lead to a statistically significant change in the number of AECOPD hospitalizations. Full article
(This article belongs to the Special Issue Exposure Assessment of Air Pollution (2nd Edition))
Show Figures

Figure 1

12 pages, 514 KiB  
Article
Dysregulated Coagulation and Fibrinolysis Are Present in Patients Admitted to the Emergency Department with Acute Hypoxemic Respiratory Failure: A Prospective Study
by Chrysi Keskinidou, Alice Georgia Vassiliou, Elena Papoutsi, Edison Jahaj, Ioanna Dimopoulou, Ilias Siempos and Anastasia Kotanidou
Biomedicines 2024, 12(5), 1081; https://doi.org/10.3390/biomedicines12051081 (registering DOI) - 13 May 2024
Abstract
Acute hypoxemic respiratory failure (AHRF) is defined as acute and progressive, and patients are at a greater risk of developing acute respiratory distress syndrome (ARDS). Until now, most studies have focused on prognostic and diagnostic biomarkers in ARDS. Since there is evidence supporting [...] Read more.
Acute hypoxemic respiratory failure (AHRF) is defined as acute and progressive, and patients are at a greater risk of developing acute respiratory distress syndrome (ARDS). Until now, most studies have focused on prognostic and diagnostic biomarkers in ARDS. Since there is evidence supporting a connection between dysregulated coagulant and fibrinolytic pathways in ARDS progression, it is plausible that this dysregulation also exists in AHRF. The aim of this study was to explore whether levels of soluble endothelial protein C receptor (sEPCR) and plasminogen differentiate patients admitted to the emergency department (ED) with AHRF. sEPCR and plasminogen levels were measured in 130 AHRF patients upon ED presentation by ELISA. Our results demonstrated that patients presenting to the ED with AHRF had elevated levels of sEPCR and plasminogen. It seems that dysregulation of coagulation and fibrinolysis occur in the early stages of respiratory failure requiring hospitalisation. Further research is needed to fully comprehend the contribution of sEPCR and plasminogen in AHRF. Full article
(This article belongs to the Special Issue Molecular Researches in Pro-thrombotic Disorders)
19 pages, 2705 KiB  
Article
Rural Buildings for Sustainable Development: A Real Estate Market Analysis in Southern Italy
by Giuseppe Parete, Giovanni Ottomano Palmisano, Annalisa De Boni, Rocco Roma and Claudio Acciani
Sustainability 2024, 16(10), 4086; https://doi.org/10.3390/su16104086 (registering DOI) - 13 May 2024
Abstract
The profound transformations of traditional rural landscapes have heightened attention towards the recovery and valorisation of their buildings, often abandoned, to accommodate new landscape usage needs. This aligns with the principles of sustainable landscape management. However, knowledge of the rural real estate market [...] Read more.
The profound transformations of traditional rural landscapes have heightened attention towards the recovery and valorisation of their buildings, often abandoned, to accommodate new landscape usage needs. This aligns with the principles of sustainable landscape management. However, knowledge of the rural real estate market remains largely unexplored. This research aims to define and examine the key features influencing the purchase of rural buildings, for shedding light on their market. The objective is to provide useful new insight to the property appraisers and real estate agents involved in the sale of traditional rural buildings, even if in conditions of degradation or abandonment and in traditional landscape contexts. Furthermore, these results could serve as a valuable resource for policymakers, enabling them to indirectly evaluate the impacts of urban and landscape policies on buyers’ preferences regarding key features of rural properties. The research focused on the ‘trulli’, traditional buildings located in the Valle d’Itria (Puglia, Southern Italy). First, a detailed market analysis was carried out with the support of local real estate experts, to survey the transactions of trulli and identify the features influencing their purchase. Second, the obtained dataset was analysed through network analysis, which enabled us to explore the role and importance assigned by buyers to the identified features. The results highlighted that the quality of the landscape where trulli are located changed the buyers’ viewpoint on the purchase features. In greater detail, price, area, potable water accessibility and level of maintenance of trulli were the most crucial features, particularly in high and medium landscape value zones, compatible with touristic and recreational activities. On the other hand, the annex agricultural surface covered a central function in low landscape value zone for possible agricultural uses. Full article
24 pages, 2778 KiB  
Article
Discrete Dynamic System Modeling for Simulated Moving Bed Processes
by Chao-Fan Xie, Hong Zhang and Rey-Chue Hwang
Mathematics 2024, 12(10), 1520; https://doi.org/10.3390/math12101520 (registering DOI) - 13 May 2024
Abstract
Although the simulated moving bed (SMB) process boasts advantages such as high productivity and low consumption, the cost of obtaining optimized parameters through practical experiments to control the separation process can be enormous due to its complex nonlinear characteristics. Consequently, the successful transformation [...] Read more.
Although the simulated moving bed (SMB) process boasts advantages such as high productivity and low consumption, the cost of obtaining optimized parameters through practical experiments to control the separation process can be enormous due to its complex nonlinear characteristics. Consequently, the successful transformation of the SMB separation process into a mathematical dynamic model for computer simulation would greatly reduce the research costs associated with experimental studies. In this study, the Crank–Nicolson method was employed to discretize and dynamize the SMB process, enabling the simulation of processes under both linear and Langmuir isotherms. The results of the simulation experiments demonstrated the feasibility and high efficiency of this approach, thereby establishing a solid foundation for further advancements in online control strategies. Full article
(This article belongs to the Special Issue Advances in Applied Mathematics, Mechanics and Engineering)
12 pages, 4471 KiB  
Article
Dual Enhancement Network for Infrared Small Target Detection
by Xinyi Wu, Xudong Hu, Huaizheng Lu, Chaopeng Li, Lei Zhang and Weifang Huang
Appl. Sci. 2024, 14(10), 4132; https://doi.org/10.3390/app14104132 (registering DOI) - 13 May 2024
Abstract
Infrared small target detection (IRSTD) is crucial for applications in security surveillance, unmanned aerial vehicle identification, military reconnaissance, and other fields. However, small targets often suffer from resolution limitations, background complexity, etc., in infrared images, which poses a great challenge to IRSTD, especially [...] Read more.
Infrared small target detection (IRSTD) is crucial for applications in security surveillance, unmanned aerial vehicle identification, military reconnaissance, and other fields. However, small targets often suffer from resolution limitations, background complexity, etc., in infrared images, which poses a great challenge to IRSTD, especially due to the noise interference and the presence of tiny, low-luminance targets. In this paper, we propose a novel dual enhancement network (DENet) to suppress background noise and enhance dim small targets. Specifically, to address the problem of complex backgrounds in infrared images, we have designed the residual sparse enhancement (RSE) module, which sparsely propagates a number of representative pixels between any adjacent feature pyramid layers instead of a simple summation. To handle the problem of infrared targets being extremely dim and small, we have developed a spatial attention enhancement (SAE) module to adaptively enhance and highlight the features of dim small targets. In addition, we evaluated the effectiveness of the modules in the DENet model through ablation experiments. Extensive experiments on three public infrared datasets demonstrated that our approach can greatly enhance dim small targets, where the average values of intersection over union (IoU), probability of detection (Pd), and false alarm rate (Fa) reached up to 77.33%, 97.30%, and 9.299%, demonstrating a performance superior to the state-of-the-art IRSTD method. Full article
Show Figures

Figure 1

19 pages, 1440 KiB  
Article
Effect of Irrigation Water Quality and Soil Compost Treatment on Salinity Management to Improve Soil Health and Plant Yield
by Subanky Suvendran, David Johnson, Miguel Acevedo, Breana Smithers and Pei Xu
Water 2024, 16(10), 1391; https://doi.org/10.3390/w16101391 (registering DOI) - 13 May 2024
Abstract
Increasing soil salinity and degraded irrigation water quality are major challenges for agriculture. This study investigated the effects of irrigation water quality and incorporating compost (3% dry mass in soil) on minimizing soil salinization and promoting sustainable cropping systems. A greenhouse study used [...] Read more.
Increasing soil salinity and degraded irrigation water quality are major challenges for agriculture. This study investigated the effects of irrigation water quality and incorporating compost (3% dry mass in soil) on minimizing soil salinization and promoting sustainable cropping systems. A greenhouse study used brackish water (electrical conductivity of 2010 µS/cm) and agricultural water (792 µS/cm) to irrigate Dundale pea and clay loam soil. Compost treatment enhanced soil water retention with soil moisture content above 0.280 m3/m3, increased plant carbon assimilation by ~30%, improved plant growth by >50%, and reduced NO3 leaching from the soil by 16% and 23.5% for agricultural and brackish water irrigation, respectively. Compared to no compost treatment, the compost-incorporated soil irrigated with brackish water showed the highest plant growth by increasing plant fresh weight by 64%, dry weight by 50%, root length by 121%, and plant height by 16%. Compost treatment reduced soil sodicity during brackish water irrigation by promoting the leaching of Cl and Na+ from the soil. Compost treatment provides an environmentally sustainable approach to managing soil salinity, remediating the impact of brackish water irrigation, improving soil organic matter, enhancing the availability of water and nutrients to plants, and increasing plant growth and carbon sequestration potential. Full article
(This article belongs to the Special Issue Soil Water Use and Irrigation Management)
Show Figures

Figure 1

18 pages, 1879 KiB  
Article
Parameter Tuning Approach for Incremental Nonlinear Dynamic Inversion-Based Flight Controllers
by Mark Henkenjohann, Udo Nolte, Fabian Sion, Christian Henke and Ansgar Trächtler
Actuators 2024, 13(5), 187; https://doi.org/10.3390/act13050187 (registering DOI) - 13 May 2024
Abstract
Incremental nonlinear dynamic inversion (INDI) is a widely used approach to controlling UAVs with highly nonlinear dynamics. One key element of INDI-based controllers is the control allocation realizing pseudo controls using available actuators. However, the tracking of commanded pseudo controls is not the [...] Read more.
Incremental nonlinear dynamic inversion (INDI) is a widely used approach to controlling UAVs with highly nonlinear dynamics. One key element of INDI-based controllers is the control allocation realizing pseudo controls using available actuators. However, the tracking of commanded pseudo controls is not the only objective considered during control allocation. Since the approach only works locally due to linearization and the solution is often ambiguous, additional aspects like control efforts or penalizing the deviation of certain states must be considered. Conducting the control allocation by solving a quadratic program this results in a considerable number of weighting parameters, which must be tuned during control design. Currently, this is conducted manually and is therefore time consuming. An automated approach for tuning these parameters is therefore highly beneficial. Thus, this paper presents and evaluates a model-based approach automatically tuning the control allocation parameters of a tiltrotor VTOL using an optimization algorithm. This optimization algorithm searches for optimal parameters minimizing a cost functional that reflects the design target. This cost functional is calculated based on a test mission for the VTOL which is conducted within a simulation environment. The test mission represents the common operating range of the VTOL. The simulation environment consists of an aircraft model as well as a model of the INDI-based controller which is dependent on the control allocation parameters. On this basis, model-based optimization is conducted and the optimal parameters are identified. Finally, successful real-world tests on a 4-degrees-of-freedom testbench using the identified parameters are presented. Since the control allocation parameters can significantly influence the aircraft’s stability, the 4-DOF testbench for the aircraft is required for rapid validation of the parameters at a minimum amount of risk. Full article
20 pages, 2733 KiB  
Article
Flexural Capacity of the Normal Sections of Concrete Beams Strengthened with Corrugated Steel Plates
by Xianda Feng, Dejun Liu, Xiao Long, Kang Duan, Jianping Zuo, Wei Liu and Haiyang Dong
Buildings 2024, 14(5), 1398; https://doi.org/10.3390/buildings14051398 (registering DOI) - 13 May 2024
Abstract
To explore the law of load-carrying performance enhancement of concrete beams reinforced with corrugated steel plates (CSPs), three groups of controlled bending tests were conducted on five beam specimens. The load-bearing capacity of concrete members commensurately increased with the thickness of reinforcing flat [...] Read more.
To explore the law of load-carrying performance enhancement of concrete beams reinforced with corrugated steel plates (CSPs), three groups of controlled bending tests were conducted on five beam specimens. The load-bearing capacity of concrete members commensurately increased with the thickness of reinforcing flat and corrugated steel plates. Additionally, for the same amount of steel, the load-bearing capacity of concrete beams improved more with CSP reinforcement than with reinforcement with flat steel plates. Accordingly, a theoretical formula for the moment of inertia of the combined section of a CSP-reinforced concrete beam was derived. Comparison verification showed that the calculation results for the beams reinforced with CSPs of different thicknesses were highly accurate. Finally, based on the damage mode of the CSP-reinforced concrete beam specimens, a formula for calculating the flexural bearing capacity of the positive cross-section of the beam with corrugated steel reinforcement was established. The calculated values agreed with the experimental values, which validated the flexural load capacity theory pertaining to positive sections and the flexural capacity model for reinforced beams. Full article
(This article belongs to the Section Building Structures)
13 pages, 1230 KiB  
Article
Examining the Effects of Nutrient Supplementation on Metabolic Pathways via Mitochondrial Ferredoxin in Aging Ovaries
by Chia-Chun Wu, Chia-Jung Li, Li-Te Lin, Zhi-Hong Wen, Jiin-Tsuey Cheng and Kuan-Hao Tsui
Nutrients 2024, 16(10), 1470; https://doi.org/10.3390/nu16101470 (registering DOI) - 13 May 2024
Abstract
As women age, oocytes are susceptible to a myriad of dysfunctions, including mitochondrial dysfunction, impaired DNA repair mechanisms, epigenetic alterations, and metabolic disturbances, culminating in reduced fertility rates among older individuals. Ferredoxin (FDX) represents a highly conserved iron–sulfur (Fe–S) protein essential for electron [...] Read more.
As women age, oocytes are susceptible to a myriad of dysfunctions, including mitochondrial dysfunction, impaired DNA repair mechanisms, epigenetic alterations, and metabolic disturbances, culminating in reduced fertility rates among older individuals. Ferredoxin (FDX) represents a highly conserved iron–sulfur (Fe–S) protein essential for electron transport across multiple metabolic pathways. Mammalian mitochondria house two distinct ferredoxins, FDX1 and FDX2, which share structural similarities and yet perform unique functions. In our investigation into the regulatory mechanisms governing ovarian aging, we employed a comprehensive multi-omics analysis approach, integrating spatial transcriptomics, single-cell RNA sequencing, human ovarian pathology, and clinical biopsy data. Previous studies have highlighted intricate interactions involving excessive lipid peroxide accumulation, redox-induced metal ion buildup, and alterations in cellular energy metabolism observed in aging cells. Through a multi-omics analysis, we observed a notable decline in the expression of the critical gene FDX1 as ovarian age progressed. This observation prompted speculation regarding FDX1’s potential as a promising biomarker for ovarian aging. Following this, we initiated a clinical trial involving 70 patients with aging ovaries. These patients were administered oral nutritional supplements consisting of DHEA, ubiquinol CoQ10, and Cleo-20 T3 for a period of two months to evaluate alterations in energy metabolism regulated by FDX1. Our results demonstrated a significant elevation in FDX1 levels among participants receiving nutritional supplementation. We hypothesize that these nutrients potentiate mitochondrial tricarboxylic acid cycle (TCA) activity or electron transport chain (ETC) efficiency, thereby augmenting FDX1 expression, an essential electron carrier in metabolic pathways, while concurrently mitigating lipid peroxide accumulation and cellular apoptosis. In summary, our findings underscore the potential of nutritional intervention to enhance in vitro fertilization outcomes in senescent cells by bolstering electron transport proteins, thus optimizing energy metabolism and improving oocyte quality in aging women. Full article
(This article belongs to the Special Issue Recent Advances in Nutrigenomics and Nutrigenetics)
34 pages, 1784 KiB  
Review
A Comprehensive Understanding of Thermal Barrier Coatings (TBCs): Applications, Materials, Coating Design and Failure Mechanisms
by Maria Bogdan and Ildiko Peter
Metals 2024, 14(5), 575; https://doi.org/10.3390/met14050575 (registering DOI) - 13 May 2024
Abstract
This review offers a comprehensive analysis of thermal barrier coatings (TBCs) applied to metallic materials. By reviewing the recent literature, this paper reports on a collection of technical information, involving the structure and role of TBCs, various materials and coating processes, as well [...] Read more.
This review offers a comprehensive analysis of thermal barrier coatings (TBCs) applied to metallic materials. By reviewing the recent literature, this paper reports on a collection of technical information, involving the structure and role of TBCs, various materials and coating processes, as well as the mechanisms involved in the durability and failure of TBCs. Although TBCs have been successfully utilized in advanced applications for nearly five decades, they continue to be a subject of keen interest and ongoing study in the world of materials science, with overviews of the field’s evolution remaining ever relevant. Thus, this paper outlines the current requirements of the main application areas of TBCs (aerospace, power generation and the automotive and naval industries) and the properties and resistance to thermal, mechanical and chemical stress of the different types of materials used, such as zirconates, niobates, tantalates or mullite. Additionally, recent approaches in the literature, such as high-entropy coatings and multilayer coatings, are presented and discussed. By analyzing the failure processes of TBCs, issues related to delamination, spallation, erosion and oxidation are revealed. Integrating TBCs with the latest generations of superalloys, as well as examining heat transfer mechanisms, could represent key areas for in-depth study. Full article

Open Access Journals

Browse by Indexing Browse by Subject Selected Journals
Back to TopTop