The 2023 MDPI Annual Report has
been released!
 
41 pages, 13475 KiB  
Review
New Advances in Materials, Applications, and Design Optimization of Thermocline Heat Storage: Comprehensive Review
by Yunshen Zhang, Yun Guo, Jiaao Zhu, Weijian Yuan and Feng Zhao
Energies 2024, 17(10), 2403; https://doi.org/10.3390/en17102403 (registering DOI) - 16 May 2024
Abstract
To achieve sustainable development goals and meet the demand for clean and efficient energy utilization, it is imperative to advance the penetration of renewable energy in various sectors. Energy storage systems can mitigate the intermittent issues of renewable energy and enhance the efficiency [...] Read more.
To achieve sustainable development goals and meet the demand for clean and efficient energy utilization, it is imperative to advance the penetration of renewable energy in various sectors. Energy storage systems can mitigate the intermittent issues of renewable energy and enhance the efficiency and economic viability of existing energy facilities. Among various energy storage technologies, thermocline heat storage (THS) has garnered widespread attention from researchers due to its stability and economic advantages. Currently, there are only a few review articles focusing on THS, and there is a gap in the literature regarding the optimization design of THS systems. Therefore, this paper provides a comprehensive review of the recent research progress in THS, elucidating its principles, thermal storage materials, applications, and optimization designs. The novelty of this work lies in the detailed classification and analysis of various optimization designs for THS, including tank shape, aspect ratio, inlet/outlet configuration, thermal energy storage materials arrangement, operating strategies, and numerical model optimization approaches. The limitations of existing research are also identified, and future perspectives are proposed, aiming to provide recommendations for THS research and contribute to the development and promotion of THS technology. Full article
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14 pages, 3758 KiB  
Article
Gait Pattern Identification Using Gait Features
by Min-Jung Kim, Ji-Hun Han, Woo-Chul Shin and Youn-Sik Hong
Electronics 2024, 13(10), 1956; https://doi.org/10.3390/electronics13101956 - 16 May 2024
Abstract
Gait analysis plays important roles in various applications such as exercise therapy, biometrics, and robot control. It can also be used to prevent and improve movement disorders and monitor health conditions. We implemented a wearable module equipped with an MPU-9250 IMU sensor, and [...] Read more.
Gait analysis plays important roles in various applications such as exercise therapy, biometrics, and robot control. It can also be used to prevent and improve movement disorders and monitor health conditions. We implemented a wearable module equipped with an MPU-9250 IMU sensor, and Bluetooth modules were implemented on an Arduino Uno R3 board for gait analysis. Gait cycles were identified based on roll values measured by the accelerometer embedded in the IMU sensor. By superimposing the gait cycles that occurred during the walking period, they could be analyzed using statistical methods. We found that the subjects could be identified using the gait feature points extracted through the statistical modeling process. To validate the feasibility of feature-based gait pattern identification, we constructed various machine learning models and compared the accuracy of their gait pattern identification. Based on this, we also investigated whether there was a significant difference between the gait patterns of people who used cell phones while walking and those who did not. Full article
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13 pages, 777 KiB  
Article
Strategies to Improve the Quality of Goat Yogurt: Whey Protein Supplementation and Milk Pre-Treatment with High Shear Dispersion Assisted by Ultrasound
by Lorena Soares Xavier, Flaviana Coelho Pacheco, Gabriela Aparecida Nalon, Jeferson Silva Cunha, Fabio Ribeiro dos Santos, Ana Flávia Coelho Pacheco, Alline Artigiani Lima Tribst and Bruno Ricardo de Castro Leite Júnior
Foods 2024, 13(10), 1558; https://doi.org/10.3390/foods13101558 (registering DOI) - 16 May 2024
Abstract
This work investigated the fermentation kinetics and characteristics of goat yogurt supplemented with bovine whey protein isolate (WPI) (0%, 2.5% and 5.0%) subjected to high shear dispersion (HSD) assisted by ultrasound (US). Protein supplementation and the physical processes increased the electronegativity of the [...] Read more.
This work investigated the fermentation kinetics and characteristics of goat yogurt supplemented with bovine whey protein isolate (WPI) (0%, 2.5% and 5.0%) subjected to high shear dispersion (HSD) assisted by ultrasound (US). Protein supplementation and the physical processes increased the electronegativity of the zeta potential (≤60%), whereas particle size reduction was observed only with physical processes (≤42%). The addition of 2.5% WPI reduced yogurt fermentation time by 30 min. After 24 h of storage at 7 °C, lactic acid bacteria counts did not differ between samples (≥8 log CFU/mL), and the supplementation was sufficient to increase the apparent viscosity (≤5.65 times) and water-holding capacity (WHC) of the yogurt (≤35% increase). However, supplementation combined with physical processes promoted greater improvements in these parameters (6.41 times in apparent viscosity and 48% in WHC) (p < 0.05), as confirmed by the denser and better-organized protein clusters observed in microscopic evaluation. Thus, both approaches proved to be promising alternatives to improve goat yogurt quality. Therefore, the decision to adopt these strategies, either independently or in combination, should consider cost implications, the product quality, and market demand. Full article
29 pages, 1059 KiB  
Review
Emerging Technologies for Remote Sensing of Floating and Submerged Plastic Litter
by Lonneke Goddijn-Murphy, Victor Martínez-Vicente, Heidi M. Dierssen, Valentina Raimondi, Erio Gandini, Robert Foster and Ved Chirayath
Remote Sens. 2024, 16(10), 1770; https://doi.org/10.3390/rs16101770 (registering DOI) - 16 May 2024
Abstract
Most advances in the remote sensing of floating marine plastic litter have been made using passive remote-sensing techniques in the visible (VIS) to short-wave-infrared (SWIR) parts of the electromagnetic spectrum based on the spectral absorption features of plastic surfaces. In this paper, we [...] Read more.
Most advances in the remote sensing of floating marine plastic litter have been made using passive remote-sensing techniques in the visible (VIS) to short-wave-infrared (SWIR) parts of the electromagnetic spectrum based on the spectral absorption features of plastic surfaces. In this paper, we present developments of new and emerging remote-sensing technologies of marine plastic litter such as passive techniques: fluid lensing, multi-angle polarimetry, and thermal infrared sensing (TIS); and active techniques: light detection and ranging (LiDAR), multispectral imaging detection and active reflectance (MiDAR), and radio detection and ranging (RADAR). Our review of the detection capabilities and limitations of the different sensing technologies shows that each has their own weaknesses and strengths, and that there is not one single sensing technique that applies to all kinds of marine litter under every different condition in the aquatic environment. Rather, we should focus on the synergy between different technologies to detect marine plastic litter and potentially the use of proxies to estimate its presence. Therefore, in addition to further developing remote-sensing techniques, more research is needed in the composition of marine litter and the relationships between marine plastic litter and their proxies. In this paper, we propose a common vocabulary to help the community to translate concepts among different disciplines and techniques. Full article
(This article belongs to the Section Environmental Remote Sensing)
13 pages, 726 KiB  
Article
A Revisit to Sunk Cost Fallacy for Two-Stage Stochastic Binary Decision Making
by Xuecheng Tian, Bo Jiang, King-Wah Pang, Yuquan Du, Yong Jin and Shuaian Wang
Mathematics 2024, 12(10), 1557; https://doi.org/10.3390/math12101557 (registering DOI) - 16 May 2024
Abstract
This paper undertakes a revisit of the sunk cost fallacy, which refers to the tendency of people to persist investing resources into something, even if it is destined to have no good outcome. We emphasize that the utilities associated with different alternatives are [...] Read more.
This paper undertakes a revisit of the sunk cost fallacy, which refers to the tendency of people to persist investing resources into something, even if it is destined to have no good outcome. We emphasize that the utilities associated with different alternatives are not static for decision makers, which is exactly opposite to the traditional perspective. This paper argues that the utility of an option may change due to the choice of another option, suggesting that decisions considered irrational by the traditional analytical method, i.e., sunk cost fallacy, may be rational. We propose a novel analytical method for decision making with sunk cost when considering the utility change and validate the effectiveness of this method through mathematical modeling and computational experiments. This paper mathematically describes such decision-making problems, analyzing the impact of changes in the utilities across different alternatives on decision making with a real-world example. Furthermore, we develop a two-stage stochastic optimization model for such decision-making problems and employ the sample average approximation (SAA) method to solve them. The results from computational experiments indicate that some decisions traditionally considered irrational are, in fact, rational when the utility of an option changes as a result of choosing another option. This paper, therefore, highlights the significance of incorporating utility changes into the decision-making process and stands as a valuable addition to the literature, offering a refreshed and effective decision-making method for improved decision making. Full article
(This article belongs to the Special Issue Mathematical Optimization and Decision Making Analysis)
16 pages, 6031 KiB  
Article
RsRbohD1 Plays a Significant Role in ROS Production during Radish Pithiness Development
by Qiong Gong, Chaonan Wang, Weiqiang Fan, Shuiling Li, Hong Zhang, Zhiyin Huang, Xiaohui Liu, Ziyun Ma, Yong Wang and Bin Zhang
Plants 2024, 13(10), 1386; https://doi.org/10.3390/plants13101386 (registering DOI) - 16 May 2024
Abstract
Pithiness is one of the physiological diseases of radishes, which is accompanied by the accumulation of reactive oxygen species (ROS) during the sponging of parenchyma tissue in the fleshy roots. A respiratory burst oxidase homolog (Rboh, also known as NADPH oxidase) is a [...] Read more.
Pithiness is one of the physiological diseases of radishes, which is accompanied by the accumulation of reactive oxygen species (ROS) during the sponging of parenchyma tissue in the fleshy roots. A respiratory burst oxidase homolog (Rboh, also known as NADPH oxidase) is a key enzyme that catalyzes the production of ROS in plants. To understand the role of Rboh genes in radish pithiness, herein, 10 RsRboh gene families were identified in the genome of Raphanus sativus using Blastp and Hmmer searching methods and were subjected to basic functional analyses such as phylogenetic tree construction, chromosomal localization, conserved structural domain analysis, and promoter element prediction. The expression profiles of RsRbohs in five stages (Pithiness grade = 0, 1, 2, 3, 4, respectively) of radish pithiness were analyzed. The results showed that 10 RsRbohs expressed different levels during the development of radish pithiness. Except for RsRbohB and RsRbohE, the expression of other members increased and reached the peak at the P2 (Pithiness grade = 2) stage, among which RsRbohD1 showed the highest transcripts. Then, the expression of 40 genes related to RsRbohD1 and pithiness were analyzed. These results can provide a theoretical basis for improving pithiness tolerance in radishes. Full article
(This article belongs to the Special Issue The Growth and Development of Vegetable Crops)
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9 pages, 391 KiB  
Article
Risk Factor Analysis for Growth Arrest in Paediatric Physeal Fractures—A Prospective Study
by Nikki Hooper, Liam Johnson, Nicole Banting, Rubini Pathy, Emily K. Schaeffer, Jeffrey N. Bone, Bryn O. Zomar, Ash Sandhu, Caitlyn Siu, Anthony P. Cooper, Christopher Reilly and Kishore Mulpuri
J. Clin. Med. 2024, 13(10), 2946; https://doi.org/10.3390/jcm13102946 (registering DOI) - 16 May 2024
Abstract
Fractures through the physis account for 18–30% of all paediatric fractures, leading to growth arrest in up to 5.5% of cases. We have limited knowledge to predict which physeal fractures result in growth arrest and subsequent deformity or limb length discrepancy. The purpose [...] Read more.
Fractures through the physis account for 18–30% of all paediatric fractures, leading to growth arrest in up to 5.5% of cases. We have limited knowledge to predict which physeal fractures result in growth arrest and subsequent deformity or limb length discrepancy. The purpose of this study is to identify factors associated with physeal growth arrest to improve patient outcomes. Methods: This prospective cohort study was designed to develop a clinical prediction model for growth arrest after physeal injury. Patients ≤ 18 years old presenting within four weeks of injury were enrolled if they had open physes and sustained a physeal fracture of the humerus, radius, ulna, femur, tibia or fibula. Patients with prior history of same-site fracture or a condition known to alter bone growth or healing were excluded. Demographic data, potential prognostic indicators, and radiographic data were collected at baseline, during healing, and at one- and two-years post-injury. Results: A total of 332 patients had at least six months of follow-up or a diagnosis of growth arrest within six months of injury. In a comparison analysis, patients who developed growth arrest were more likely to be older (12.8 years vs. 9.4 years) and injured on the right side (53.0% vs. 45.7%). Initial displacement and angulation rates were higher in the growth arrest group (59.0% vs. 47.8% and 47.0% vs. 38.8%, respectively), but the amount of angulation was similar (27.0° vs. 28.4°). Rates of growth arrest were highest in distal femoral fractures (86%). Conclusion: The incidence of growth arrest in this patient population appears higher than the past literature reports at 30.1%. However, there may be variances in diagnostic criteria for growth arrest, and the true incidence may be lower. A number of patients were approaching skeletal maturity, and any growth arrest is likely to have less clinical significance in these cases. Further prospective long-term follow-up is required to determine risk factors, incidence, and true clinical impact of growth arrest when it does occur. Full article
15 pages, 434 KiB  
Review
Obesogens in Adolescence: Challenging Aspects and Prevention Strategies
by Marina Nicolaou, Meropi Toumba, Alexandros Kythreotis, Habib Daher and Nicos Skordis
Children 2024, 11(5), 602; https://doi.org/10.3390/children11050602 (registering DOI) - 16 May 2024
Abstract
Childhood obesity has become a global epidemic, with significant increases in prevalence over recent decades. While excessive calorie consumption and physical inactivity are known factors, emerging research highlights the role of endocrine-disrupting chemicals (EDCs), particularly obesogens, in obesity’s pathogenesis. This review explores the [...] Read more.
Childhood obesity has become a global epidemic, with significant increases in prevalence over recent decades. While excessive calorie consumption and physical inactivity are known factors, emerging research highlights the role of endocrine-disrupting chemicals (EDCs), particularly obesogens, in obesity’s pathogenesis. This review explores the historical context of the environmental obesogens hypothesis, their sources, mechanism of action, impact on prenatal and postnatal development, and epigenetics. Additionally, it discusses the long-term consequences of childhood obesity and proposes prevention strategies that will mitigate negative health effects. Obesogens were found to disrupt hormonal balance and metabolic processes through various mechanisms such as altering gene expression, hormonal interference, and inflammation. Especially significant was exposure during critical windows of development, which correlates with an increased risk of obesity in childhood or adolescence. Long-term effects of childhood obesity include chronic health conditions and psychosocial issues. A comprehensive approach is necessary to address childhood obesity encompassing genetic, environmental, and lifestyle factors. Prevention strategies should focus on reducing obesogen exposure, promoting healthy lifestyles, and implementing regulatory policies. Future research should investigate obesogens–diet interactions, microbiome impacts, and combined obesogens effects. Long-term human studies are also crucial for validating findings from animal models and allowing for informed decision-making to combat the obesity pandemic. Full article
(This article belongs to the Special Issue Adolescent Weight Management: Advances and Future Challenges)
13 pages, 2536 KiB  
Article
Myricetin Acts as an Inhibitor of Type II NADH Dehydrogenase from Staphylococcus aureus
by Jia-Le Zhou, Hao-Han Chen, Jian Xu, Ming-Yu Huang, Jun-Feng Wang, Hao-Jie Shen, Sheng-Xiang Shen, Cheng-Xian Gao and Chao-Dong Qian
Molecules 2024, 29(10), 2354; https://doi.org/10.3390/molecules29102354 (registering DOI) - 16 May 2024
Abstract
Background: Staphylococcus aureus is a common pathogenic microorganism in humans and animals. Type II NADH oxidoreductase (NDH-2) is the only NADH:quinone oxidoreductase present in this organism and represents a promising target for the development of anti-staphylococcal drugs. Recently, myricetin, a natural flavonoid from [...] Read more.
Background: Staphylococcus aureus is a common pathogenic microorganism in humans and animals. Type II NADH oxidoreductase (NDH-2) is the only NADH:quinone oxidoreductase present in this organism and represents a promising target for the development of anti-staphylococcal drugs. Recently, myricetin, a natural flavonoid from vegetables and fruits, was found to be a potential inhibitor of NDH-2 of S. aureus. The objective of this study was to evaluate the inhibitory properties of myricetin against NDH-2 and its impact on the growth and expression of virulence factors in S. aureus. Results: A screening method was established to identify effective inhibitors of NDH-2, based on heterologously expressed S. aureus NDH-2. Myricetin was found to be an effective inhibitor of NDH-2 with a half maximal inhibitory concentration (IC50) of 2 μM. In silico predictions and enzyme inhibition kinetics further characterized myricetin as a competitive inhibitor of NDH-2 with respect to the substrate menadione (MK). The minimum inhibitory concentrations (MICs) of myricetin against S. aureus strains ranged from 64 to 128 μg/mL. Time–kill assays showed that myricetin was a bactericidal agent against S. aureus. In line with being a competitive inhibitor of the NDH-2 substrate MK, the anti-staphylococcal activity of myricetin was antagonized by MK-4. In addition, myricetin was found to inhibit the gene expression of enterotoxin SeA and reduce the hemolytic activity induced by S. aureus culture on rabbit erythrocytes in a dose-dependent manner. Conclusions: Myricetin was newly discovered to be a competitive inhibitor of S. aureus NDH-2 in relation to the substrate MK. This discovery offers a fresh perspective on the anti-staphylococcal activity of myricetin. Full article
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20 pages, 7082 KiB  
Article
Induced Pluripotent Stem Cell-Derived Fibroblasts Efficiently Engage Senescence Pathways but Show Increased Sensitivity to Stress Inducers
by Marie-Lyn Goyer, Cynthia Desaulniers-Langevin, Anthony Sonn, Georgio Mansour Nehmo, Véronique Lisi, Basma Benabdallah, Noël J.-M. Raynal and Christian Beauséjour
Cells 2024, 13(10), 849; https://doi.org/10.3390/cells13100849 (registering DOI) - 16 May 2024
Abstract
The risk of aberrant growth of induced pluripotent stem cell (iPSC)-derived cells in response to DNA damage is a potential concern as the tumor suppressor genes TP53 and CDKN2A are transiently inactivated during reprogramming. Herein, we evaluate the integrity of cellular senescence pathways [...] Read more.
The risk of aberrant growth of induced pluripotent stem cell (iPSC)-derived cells in response to DNA damage is a potential concern as the tumor suppressor genes TP53 and CDKN2A are transiently inactivated during reprogramming. Herein, we evaluate the integrity of cellular senescence pathways and DNA double-strand break (DSB) repair in Sendai virus reprogrammed iPSC-derived human fibroblasts (i-HF) compared to their parental skin fibroblasts (HF). Using transcriptomics analysis and a variety of functional assays, we show that the capacity of i-HF to enter senescence and repair DSB is not compromised after damage induced by ionizing radiation (IR) or the overexpression of H-RASV12. Still, i-HF lines are transcriptionally different from their parental lines, showing enhanced metabolic activity and higher expression of p53-related effector genes. As a result, i-HF lines generally exhibit increased sensitivity to various stresses, have an elevated senescence-associated secretory phenotype (SASP), and cannot be immortalized unless p53 expression is knocked down. In conclusion, while our results suggest that i-HF are not at a greater risk of transformation, their overall hyperactivation of senescence pathways may impede their function as a cell therapy product. Full article
(This article belongs to the Special Issue Reprogrammed Cells in Disease Modeling and Drug Discovery II)
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32 pages, 367 KiB  
Article
The Dynamical and Kinetic Equations of Four-Five-Six-Wave Resonance for Ocean Surface Gravity Waves in Water with a Finite Depth
by Guobin Lin
Symmetry 2024, 16(5), 618; https://doi.org/10.3390/sym16050618 (registering DOI) - 16 May 2024
Abstract
Based on the Hamilton canonical equations for ocean surface waves with four-five-six-wave resonance conditions , the determinate dynamical equation of four-five-six-wave resonances for ocean surface gravity waves in water with a finite depth is established, thus leading to the elimination of the nonresonant [...] Read more.
Based on the Hamilton canonical equations for ocean surface waves with four-five-six-wave resonance conditions , the determinate dynamical equation of four-five-six-wave resonances for ocean surface gravity waves in water with a finite depth is established, thus leading to the elimination of the nonresonant second-, third-, fourth-, and fifth-order nonlinear terms though a suitable canonical transformation. The four kernels of the equation and the 18 coefficients of the transformation are expressed in explicit form in terms of the expansion coefficients of the gravity wave Hamiltonian in integral-power series in normal variables. The possibilities of the existence of integrals of motion for the wave momentum and the wave action are discussed, particularly the special integrals for the latter. For ocean surface capillary–gravity waves on a fluid with a finite depth, the sixth-order expansion coefficients of the Hamiltonian in integral-power series in normal variables are concretely provided, thus naturally including the classical fifth-order kinetic energy expansion coefficients given by Krasitskii. Full article
(This article belongs to the Special Issue Symmetrical Mathematical Computation in Fluid Dynamics)
21 pages, 1072 KiB  
Review
Review: A Contemporary, Multifaced Insight into Psoriasis Pathogenesis
by Rucsandra Cristina Dascălu, Andreea Lili Bărbulescu, Loredana Elena Stoica, Ștefan Cristian Dinescu, Cristina Elena Biță, Horațiu Valeriu Popoviciu, Răzvan Adrian Ionescu and Florentin Ananu Vreju
J. Pers. Med. 2024, 14(5), 535; https://doi.org/10.3390/jpm14050535 (registering DOI) - 16 May 2024
Abstract
Psoriasis is a chronic recurrent inflammatory autoimmune pathology with a significant genetic component and several interferences of immunological cells and their cytokines. The complex orchestration of psoriasis pathogenesis is related to the synergic effect of immune cells, polygenic alterations, autoantigens, and several other [...] Read more.
Psoriasis is a chronic recurrent inflammatory autoimmune pathology with a significant genetic component and several interferences of immunological cells and their cytokines. The complex orchestration of psoriasis pathogenesis is related to the synergic effect of immune cells, polygenic alterations, autoantigens, and several other external factors. The major act of the IL-23/IL-17 axis, strongly influencing the inflammatory pattern established during the disease activity, is visible as a continuous perpetuation of the pro-inflammatory response and keratinocyte activation and proliferation, leading to the development of psoriatic lesions. Genome-wide association studies (GWASs) offer a better view of psoriasis pathogenic pathways, with approximately one-third of psoriasis’s genetic impact on psoriasis development associated with the MHC region, with genetic loci located on chromosome 6. The most eloquent genetic factor of psoriasis, PSORS1, was identified in the MHC I site. Among the several factors involved in its complex etiology, dysbiosis, due to genetic or external stimulus, induces a burst of pro-inflammatory consequences; both the cutaneous and gut microbiome get involved in the psoriasis pathogenic process. Cutting-edge research studies and comprehensive insights into psoriasis pathogenesis, fostering novel genetic, epigenetic, and immunological factors, have generated a spectacular improvement over the past decades, securing the path toward a specific and targeted immunotherapeutic approach and delayed progression to inflammatory arthritis. This review aimed to offer insight into various domains that underline the pathogenesis of psoriasis and how they influence disease development and evolution. The pathogenesis mechanism of psoriasis is multifaceted and involves an interplay of cellular and humoral immunity, which affects susceptible microbiota and the genetic background. An in-depth understanding of the role of pathogenic factors forms the basis for developing novel and individualized therapeutic targets that can improve disease management. Full article
(This article belongs to the Special Issue Immune-Mediated Diseases)
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19 pages, 781 KiB  
Systematic Review
Bacterial Endophytes and Their Contributions to Alleviating Drought and Salinity Stresses in Wheat: A Systematic Review of Physiological Mechanisms
by Fayha Al-Hawamdeh, Jamal Y. Ayad, Kholoud M. Alananbeh and Muhanad W. Akash
Agriculture 2024, 14(5), 769; https://doi.org/10.3390/agriculture14050769 (registering DOI) - 16 May 2024
Abstract
Drought and salinity stresses significantly threaten global wheat productivity, limiting growth and reducing yields, thus endangering food security worldwide. These stresses disrupt physiological processes, impair photosynthesis, and hinder optimal growth and yield by diminishing water uptake, causing osmotic stress, ion toxicity, and oxidative [...] Read more.
Drought and salinity stresses significantly threaten global wheat productivity, limiting growth and reducing yields, thus endangering food security worldwide. These stresses disrupt physiological processes, impair photosynthesis, and hinder optimal growth and yield by diminishing water uptake, causing osmotic stress, ion toxicity, and oxidative stress. In response, various mitigation strategies have been explored, including breeding for stress-tolerant cultivars, improved irrigation techniques, and the application of exogenous osmoprotectants and soil amendments. Among these strategies, the emergence of rhizospheric and endophytic growth-promoting microorganisms has attracted significant attention. Therefore, a systematic review was undertaken to illustrate the role of endophytic bacteria in enhancing wheat tolerance to drought and salinity stresses. This review analyzes physiological mechanisms and research trends, identifies gaps, and discusses implications for sustainable agriculture. An analysis of the literature related to endophytic bacteria in wheat was conducted using databases of major publishers from 2004 to 2023. The review explores their mechanisms, such as phytohormone production and stress-responsive gene induction, emphasizing their contribution to plant growth and stress resilience. The current research trends indicate a growing interest in utilizing endophytic bacteria to mitigate these stresses in wheat cultivation, with studies focusing on understanding their physiological responses and interactions with wheat plants. Future research should concentrate on elucidating the role of endophytic bacteria in enhancing host plant tolerance to multiple stressors, as well as aspects like endophytic mechanism of action , endophytic lifestyle, and transmission pathways. Overall, endophytic bacteria offer promising avenues for sustainable agricultural practices, aiding in crop resilience and food security amid environmental challenges. Full article
(This article belongs to the Special Issue The Role of Plant Growth-Promoting Bacteria in Crop Improvement)
13 pages, 952 KiB  
Article
An Image-Based Interactive Training Method of an Upper Limb Rehabilitation Robot
by Changlong Ye, Zun Wang, Suyang Yu and Chunying Jiang
Machines 2024, 12(5), 348; https://doi.org/10.3390/machines12050348 (registering DOI) - 16 May 2024
Abstract
Aimed at the problem of human–machine interaction between patients and robots in the process of using rehabilitation robots for rehabilitation training, this paper proposes a human–machine interactive control method based on an independently developed upper limb rehabilitation robot. In this method, the camera [...] Read more.
Aimed at the problem of human–machine interaction between patients and robots in the process of using rehabilitation robots for rehabilitation training, this paper proposes a human–machine interactive control method based on an independently developed upper limb rehabilitation robot. In this method, the camera is used as a sensor, the human skeleton model is used to analyse the moving image, and the key points of the human body are extracted. Then, the three-dimensional coordinates of the key points of the human arm are extracted by depth estimation and spatial geometry, and then the real-time motion data are obtained, and the control instructions of the robot are generated from it to realise the real-time interactive control of the robot. This method can not only improve the adaptability of the system to individual patient differences, but also improve the robustness of the system, which is less affected by environmental changes. The experimental results show that this method can realise real-time control of the rehabilitation robot, and that the robot assists the patient to complete the action with high accuracy. The results show that this control method is effective and can be applied to the fields of robot control and robot-assisted rehabilitation training. Full article
(This article belongs to the Section Robotics, Mechatronics and Intelligent Machines)
11 pages, 262 KiB  
Article
Linear Generalized n-Derivations on C-Algebras*
by Shakir Ali, Amal S. Alali and Vaishali Varshney
Mathematics 2024, 12(10), 1558; https://doi.org/10.3390/math12101558 (registering DOI) - 16 May 2024
Abstract
Let n2 be a fixed integer and A be a C*-algebra. A permuting n-linear map G:AnA is known to be symmetric generalized n-derivation if there exists a symmetric n-derivation [...] Read more.
Let n2 be a fixed integer and A be a C*-algebra. A permuting n-linear map G:AnA is known to be symmetric generalized n-derivation if there exists a symmetric n-derivation D:AnA such that Gς1,ς2,,ςiςi,,ςn=Gς1,ς2,,ςi,,ςnςi+ςiD(ς1,ς2,,ςi,,ςn) holds ∀ςi,ςiA. In this paper, we investigate the structure of C*-algebras involving generalized linear n-derivations. Moreover, we describe the forms of traces of linear n-derivations satisfying certain functional identity. Full article
5 pages, 270 KiB  
Editorial
Molecular Mechanisms of Bacterial Communication and Their Biocontrol
by Corinne Barbey and Xavier Latour
Int. J. Mol. Sci. 2024, 25(10), 5443; https://doi.org/10.3390/ijms25105443 (registering DOI) - 16 May 2024
Abstract
A bacterium’s ability to colonize and adapt to an ecological niche is highly dependent on its capacity to perceive and analyze its environment and its ability to interact with its hosts and congeners [...] Full article
(This article belongs to the Special Issue Molecular Mechanisms of Bacterial Communication and Their Control)
21 pages, 7669 KiB  
Article
Navigating the Maze: Exploring Non-Oncological Complexities in Non-Small-Cell Lung Cancer
by Angela-Ștefania Marghescu, Silviu Vlăsceanu, Mădălina Preda, Mirela Țigău, Ștefan Dumitrache-Rujinski, Diana Gabriela Leonte, Elena Doina Măgheran, Adrian Tudor, Ioana Anca Bădărău, Livia Georgescu and Mariana Costache
Cancers 2024, 16(10), 1903; https://doi.org/10.3390/cancers16101903 (registering DOI) - 16 May 2024
Abstract
Pulmonary oncological pathologies are an important public health problem and the association with other pulmonary lesions may pose difficulties in diagnosis and staging or require different treatment options. To address this complexity, we conducted a retrospective observational study at the Marius Nasta Institute [...] Read more.
Pulmonary oncological pathologies are an important public health problem and the association with other pulmonary lesions may pose difficulties in diagnosis and staging or require different treatment options. To address this complexity, we conducted a retrospective observational study at the Marius Nasta Institute of Pneumophthisiology, Bucharest, Romania. Our study focused on patients admitted in 2019 with non-small-cell lung carcinoma and associated pulmonary lesions identified through surgical resection specimens. Among the 314 included patients, multiple pulmonary nodules were observed on macroscopic examination, with 12% (N = 37) exhibiting nonmalignant etiologies upon microscopic examination. These findings underscore the challenge of preoperative staging. Patients with coexisting nonmalignant lesions were similar in age, smoking habits, and professional or environmental exposure by comparison with those who presented only malignant lesions. The presentation of coexisting malignant and nonmalignant lesions may pose difficulties in diagnosing and staging pulmonary cancer. Full article
(This article belongs to the Special Issue Pathology, Diagnosis and Treatment in Non-small Cell Lung Cancer)
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16 pages, 3222 KiB  
Article
Spray Characterization of Direct Hydrogen Injection as a Green Fuel with Lower Emissions
by Raul Payri, Ricardo Novella, Khodor I. Nasser and Oscar Bori-Fabra
Energies 2024, 17(10), 2405; https://doi.org/10.3390/en17102405 (registering DOI) - 16 May 2024
Abstract
A viable green energy source for heavy industries and transportation is hydrogen. The internal combustion engine (ICE), when powered by hydrogen, offers an economical and adaptable way to quickly decarbonize the transportation industry. In general, two techniques are used to inject hydrogen into [...] Read more.
A viable green energy source for heavy industries and transportation is hydrogen. The internal combustion engine (ICE), when powered by hydrogen, offers an economical and adaptable way to quickly decarbonize the transportation industry. In general, two techniques are used to inject hydrogen into the ICE combustion chamber: port injection and direct injection. The present work examined direct injection technology, highlighting the need to understand and manage hydrogen mixing within an ICE’s combustion chamber. Before combusting hydrogen, it is critical to study its propagation and mixture behavior just immediately before burning. For this purpose, the DI-CHG.2 direct injector model by BorgWarner was used. This injector operated at 35 barG and 20 barG as maximum and minimum upstream pressures, respectively; a 5.8 g/s flow rate; and a maximum tip nozzle temperature of 250 °C. Experiments were performed using a high-pressure and high-temperature visualization vessel available at our facility. The combustion mixture prior to burning (spray) was visually controlled by the single-pass high-speed Schlieren technique. Images were used to study the spray penetration (S) and spray volume (V). Several parameters were considered to perform the experiments, such as the injection pressure (Pinj), chamber temperature (Tch), and the injection energizing time (Tinj). With pressure ratio and injection time being the parameters commonly used in jet characterization, the addition of temperature formed a more comprehensive group of parameters that should generally aid in the characterization of this type of gas jets as well as the understanding of the combined effect of the rate of injection on the overall outcome. It was observed that the increase in injection pressure (Pinj) increased the spray penetration depth and its calculated volume, as well as the amount of mass injected inside the chamber according to the ROI results; furthermore, it was also observed that with a pressure difference of 20 bar (the minimum required for the proper functioning of the injector used), cyclic variability increased. The variation in temperature inside the chamber had less of an impact on the spray shape and its penetration; instead, it determined the velocity at which the spray reached its maximum length. In addition, the injection energizing time had no effect on the spray penetration. Full article
(This article belongs to the Section A5: Hydrogen Energy)
19 pages, 5961 KiB  
Article
Daidzein and Equol: Ex Vivo and In Silico Approaches Targeting COX-2, iNOS, and the Canonical Inflammasome Signaling Pathway
by Yazmín K. Márquez-Flores, Elizdath Martínez-Galero, José Correa-Basurto, Yudibeth Sixto-López, Isabel Villegas, María Á. Rosillo, Ana Cárdeno and Catalina Alarcón-de-la-Lastra
Pharmaceuticals 2024, 17(5), 647; https://doi.org/10.3390/ph17050647 (registering DOI) - 16 May 2024
Abstract
Background: The inflammasome is a cytosolic multiprotein complex associated with multiple autoimmune diseases. Phytochemical compounds in soy (Glycine max) foods, such as isoflavones, have been reported for their anti-inflammatory properties. Aim: the anti-inflammatory activity of DZ (daidzein) and EQ (equol) were [...] Read more.
Background: The inflammasome is a cytosolic multiprotein complex associated with multiple autoimmune diseases. Phytochemical compounds in soy (Glycine max) foods, such as isoflavones, have been reported for their anti-inflammatory properties. Aim: the anti-inflammatory activity of DZ (daidzein) and EQ (equol) were investigated in an ex vivo model of LPS-stimulated murine peritoneal macrophages and by molecular docking correlation. Methods: Cells were pre-treated with DZ (25, 50, and 100 µM) or EQ (5, 10, and 25 µM), followed by LPS stimulation. The levels of PGE2, NO, TNF-α, IL-6, and IL-1β were analyzed by ELISA, whereas the expressions of COX-2, iNOS, NLRP3, ASC, caspase 1, and IL-18 were measured by Western blotting. Also, the potential for transcriptional modulation by targeting NF-κB, COX-2, iNOS, NLRP3, ASC, and caspase 1 was investigated by molecular docking. Results: The anti-inflammatory responses observed may be due to the modulation of NF-κB due to the binding of DZ or EQ, which is translated into decreased TNF-α, COX-2, iNOS, NLRP3, and ASC levels. Conclusion: This study establishes that DZ and EQ inhibit LPS-induced inflammatory responses in peritoneal murine macrophages via down-regulation of NO and PGE2 generation, as well as the inhibition of the canonical inflammasome pathway, regulating NLRP3, and consequently decreasing IL-1β and IL-18 activation. Full article
(This article belongs to the Section Medicinal Chemistry)
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12 pages, 4610 KiB  
Article
Standby Power Reduction of Home Appliance by the i-HEMS System Using Supervised Learning Techniques
by Beungyong Park, Suh-hyun Kwon and Byoungchull Oh
Energies 2024, 17(10), 2404; https://doi.org/10.3390/en17102404 (registering DOI) - 16 May 2024
Abstract
Electricity consumption in homes is on the rise due to the increasing prevalence of home appliances and longer hours spent indoors. Home energy management systems (HEMSs) are emerging as a solution to reduce electricity consumption and efficiently manage power usage at home. In [...] Read more.
Electricity consumption in homes is on the rise due to the increasing prevalence of home appliances and longer hours spent indoors. Home energy management systems (HEMSs) are emerging as a solution to reduce electricity consumption and efficiently manage power usage at home. In the past, numerous studies have been conducted on the management of electricity production and consumption through solar power. However, there are limited human-centered studies focusing on the user’s lifestyle. In this study, we propose an Intelligent Home Energy Management System (i-HEMS) and evaluate its energy-saving effectiveness through a demonstration in a standard house in Korea. The system utilizes an IoT environment, PID sensing, and behavioral pattern algorithms. We developed algorithms based on power usage monitoring data of home appliances and human body detection. These algorithms are used as the primary scheduling algorithm and a secondary algorithm for backup purposes. We explored the deep connection between power usage, environmental sensor data, and input schedule data based on Long Short-Term Memory network (LSTM) and developed an occupancy prediction algorithm. We analyzed the use of common home appliances (TV, computer, water purifier, microwave, washing machine, etc.) in a standard house and the power consumption reduction by the i-HEMS system. Through a total of six days of empirical experiments, before implementing i-HEMS, home appliances consumed 13,062 Wh. With i-HEMS, the total consumption was reduced to 10,434 Wh (a 20% reduction), with 9060 Wh attributed to home appliances and 1374 Wh to i-HEMS operation. Full article
(This article belongs to the Section G: Energy and Buildings)
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12 pages, 3622 KiB  
Article
Associations between Total Atherosclerosis Burden of Baroreceptor-Resident Arteries and ECG Abnormalities after Acute Ischemic Stroke
by Zhiyong Fu, Xin Ma, Xiaoxi Zhao, Xiangying Du and Yungao Wan
Brain Sci. 2024, 14(5), 505; https://doi.org/10.3390/brainsci14050505 (registering DOI) - 16 May 2024
Abstract
Electrocardiogram (ECG) abnormalities are the most common cardiac complications after acute ischemic stroke (AIS) and predict poor outcomes. The arterial baroreflex is an essential determinant of cardiovascular autonomic regulation, with receptors mainly residing in carotid sinuses and aortic arch. The atherosclerosis of these [...] Read more.
Electrocardiogram (ECG) abnormalities are the most common cardiac complications after acute ischemic stroke (AIS) and predict poor outcomes. The arterial baroreflex is an essential determinant of cardiovascular autonomic regulation, with receptors mainly residing in carotid sinuses and aortic arch. The atherosclerosis of these baroreceptor-resident arteries (BRA) is very common in AIS patients and might impair baroreflex function. However, the associations between the atherosclerosis of BRA and ECG abnormalities after AIS are still unknown. In total, 228 AIS patients within 7 days after onset without a pre-existing heart disease were prospectively recruited. With computed tomography angiography, atherosclerosis conditions in 10 segments of the carotid sinuses and aortic arch were scored and summed as the Total Atherosclerosis Burden of BRA (TAB-BRA), and asymptomatic coronary artery stenosis (ACAS) ≥50% was simultaneously assessed. We performed 12-lead ECG to dynamically detect abnormal repolarization, and 24 h Holter ECG to monitor arrhythmias and heart rate variability (HRV) parameters, which are reliable indicators to assess cardiac autonomic function. We found that TAB-BRA was positively associated with abnormal repolarization (OR 1.09; CI% 1.03–1.16; p = 0.003) and serious cardiac arrhythmias (OR 1.08; CI% 1.01–1.15; p = 0.021). In addition, TAB-BRA was an important predictor of abnormal repolarization, persisting over 3 days (OR 1.17; CI% 1.05–1.30; p = 0.003). However, ACAS ≥ 50% did not relate to these ECG abnormalities. TAB-BRA was negatively correlated with parasympathetic-related HRV parameters. Our results indicated that AIS patients with a high TAB-BRA are more likely to have ECG abnormalities and delayed normalization, which may relate to the decreased cardiac parasympathetic activity, but not the accompanied ACAS ≥ 50%. Full article
(This article belongs to the Topic Diagnosis and Management of Acute Ischemic Stroke)
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14 pages, 2757 KiB  
Article
Online Orientation Recognition of Single-Crystal Diamond Tools in the Process of Indexing Grinding Based on HMM and Multi-Information Fusion
by Haitao Ma, Dayu Xia and Yifan Wu
Appl. Sci. 2024, 14(10), 4236; https://doi.org/10.3390/app14104236 (registering DOI) - 16 May 2024
Abstract
Single-crystal diamond tools occupy an important position in the field of optical processing as the basis and key to advanced optical manufacturing technology, such as grating manufacturing and optical mirror-turning processing. Single-crystal diamond tools have become the cornerstone of the development of related [...] Read more.
Single-crystal diamond tools occupy an important position in the field of optical processing as the basis and key to advanced optical manufacturing technology, such as grating manufacturing and optical mirror-turning processing. Single-crystal diamond tools have become the cornerstone of the development of related industries. This paper takes a single-crystal diamond arc tool as the research object. Sound signal analysis technology and vibration signal analysis technology are comprehensively applied to the online orientation identification of a single-crystal diamond tool in the indexing grinding process. The online orientation method of the tool is explored, the sound signal and the vibration signal are taken as the characteristic signals, and a wavelet algorithm (WT) is used to reduce the noise of the vibration signal and sound signal. The kurtosis of the sound signal and the kurtosis and skewness of the vibration signal in the high-order statistics strongly related to the grinding direction of a single-crystal diamond are used as the characteristic parameters, and the online direction recognition model of the tool is established using the Hidden Markov Method (HMM). The above characteristic parameters are used as model input for multi-information fusion. The mapping relationship between the characteristic parameters of the characteristic signal and the crystal orientation of the single-crystal diamond crystal face is obtained, and then the online orientation method of the single-crystal diamond arc tool in the process of indexing grinding is formed. The effectiveness of the method is verified by experiments, and effective orientation information is provided for research on the positioning control strategy of the tool grinding process to ensure the efficiency of grinding and improve the manufacturing level of the tool. Full article
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12 pages, 304 KiB  
Article
Effects of Seed Size and Frequency on Seed Dispersal and Predation by Small Mammals
by Jiming Cheng, Min Zhang, Xingfu Yan, Chao Zhang, Jinfeng Zhang and Yonghong Luo
Biology 2024, 13(5), 353; https://doi.org/10.3390/biology13050353 (registering DOI) - 16 May 2024
Abstract
Frequency-dependent predation is common in predator–prey interactions. Size is an important characteristic of seeds and is crucial in the regeneration stage of plant seeds. However, the frequency dependence of animal predation on seed size has not been reported. In this study, we conducted [...] Read more.
Frequency-dependent predation is common in predator–prey interactions. Size is an important characteristic of seeds and is crucial in the regeneration stage of plant seeds. However, the frequency dependence of animal predation on seed size has not been reported. In this study, we conducted a field experiment and used different sizes of Liaodong oak (Quercus wutaishanica) seeds to test the frequency dependence of intraspecific seed size selection in rodents. We used the number ratio of large to small seeds as the frequency. The results show that the rate of small seeds being eaten in situ was significantly higher than that of large seeds (p < 0.05). The rates of different-sized seeds being eaten after removal decreased with increasing frequencies, and there was no significant difference between frequencies except for 1:9 and 9:1. The rates of large seeds being scatter-hoarded were significantly higher than those of small seeds at different frequencies (p < 0.05). The eating distances after removal of large seeds were significantly longer than those of small seeds at the same frequencies (p < 0.05). Furthermore, the scatter-hoarding distances of large seeds were significantly longer than those of small seeds at three frequencies (1:9, 3:7, and 9:1) (p < 0.05). That is, rodents consumed more small seeds in situ, dispersed and scatter-hoarded more large seeds, and dispersed large seeds over longer distances. Rodents exhibited a negative frequency dependence for small seeds and a positive frequency dependence for large seeds on being eaten in situ. Moreover, rodents exhibited a negative frequency dependence for large seeds and a positive frequency dependence for small seeds on being eaten after removal and scatter-hoarding. These results reveal the frequency dependence of rodent selection on seed size and provide new insights into animal-mediated seed dispersal and the regeneration of plant populations. Full article
(This article belongs to the Section Ecology)

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