The 2023 MDPI Annual Report has
been released!
 
30 pages, 2251 KiB  
Article
Sorption Behavior of Azo Dye Congo Red onto Activated Biochar from Haematoxylum campechianum Waste: Gradient Boosting Machine Learning-Assisted Bayesian Optimization for Improved Adsorption Process
by Diego Melchor Polanco Gamboa, Mohamed Abatal, Eder Lima, Francisco Anguebes Franseschi, Claudia Aguilar Ucán, Rasikh Tariq, Miguel Angel Ramírez Elías and Joel Vargas
Int. J. Mol. Sci. 2024, 25(9), 4771; https://doi.org/10.3390/ijms25094771 (registering DOI) - 27 Apr 2024
Abstract
This work aimed to describe the adsorption behavior of Congo red (CR) onto activated biochar material prepared from Haematoxylum campechianum waste (ABHC). The carbon precursor was soaked with phosphoric acid, followed by pyrolysis to convert the precursor into activated biochar. The [...] Read more.
This work aimed to describe the adsorption behavior of Congo red (CR) onto activated biochar material prepared from Haematoxylum campechianum waste (ABHC). The carbon precursor was soaked with phosphoric acid, followed by pyrolysis to convert the precursor into activated biochar. The surface morphology of the adsorbent (before and after dye adsorption) was characterized by scanning electron microscopy (SEM/EDS), BET method, X-ray powder diffraction (XRD), and Fourier-transform infrared spectroscopy (FTIR) and, lastly, pHpzc was also determined. Batch studies were carried out in the following intervals of pH = 4–10, temperature = 300.15–330.15 K, the dose of adsorbent = 1–10 g/L, and isotherms evaluated the adsorption process to determine the maximum adsorption capacity (Qmax, mg/g). Kinetic studies were performed starting from two different initial concentrations (25 and 50 mg/L) and at a maximum contact time of 48 h. The reusability potential of activated biochar was evaluated by adsorption–desorption cycles. The maximum adsorption capacity obtained with the Langmuir adsorption isotherm model was 114.8 mg/g at 300.15 K, pH = 5.4, and a dose of activated biochar of 1.0 g/L. This study also highlights the application of advanced machine learning techniques to optimize a chemical removal process. Leveraging a comprehensive dataset, a Gradient Boosting regression model was developed and fine-tuned using Bayesian optimization within a Python programming environment. The optimization algorithm efficiently navigated the input space to maximize the removal percentage, resulting in a predicted efficiency of approximately 90.47% under optimal conditions. These findings offer promising insights for enhancing efficiency in similar removal processes, showcasing the potential of machine learning in process optimization and environmental remediation. Full article
17 pages, 2698 KiB  
Article
A Ship Trajectory Prediction Method Based on an Optuna–BILSTM Model
by Yipeng Zhou, Ze Dong and Xiongguan Bao
Appl. Sci. 2024, 14(9), 3719; https://doi.org/10.3390/app14093719 (registering DOI) - 27 Apr 2024
Abstract
In the field of maritime traffic management, overcoming the challenges of low prediction accuracy and computational inefficiency in ship trajectory prediction is crucial for collision avoidance. This paper presents an advanced solution using a deep bidirectional long- and short-term memory network (BILSTM) and [...] Read more.
In the field of maritime traffic management, overcoming the challenges of low prediction accuracy and computational inefficiency in ship trajectory prediction is crucial for collision avoidance. This paper presents an advanced solution using a deep bidirectional long- and short-term memory network (BILSTM) and the Optuna hyperparameter automatic optimized framework. Utilizing automatic identification system (AIS) data to analyze ship navigation patterns, the study applies Optuna to fine-tune the hyperparameters of the BILSTM network to improve prediction accuracy and efficiency. The developed Optuna–BILSTM model shows a remarkable 7% increase in prediction accuracy over traditional back propagation (BP) neural networks and standard BILSTM models. These results not only improve ship navigation and safety but also have significant implications for the development of autonomous ship collision avoidance systems, marking a significant step toward safer and more efficient maritime traffic management. Full article
(This article belongs to the Section Marine Science and Engineering)
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27 pages, 45608 KiB  
Article
Characterization of Grape Pomace Extract Microcapsules: The Influence of Carbohydrate Co-Coating on the Stabilization of Goat Whey Protein as a Primary Coating
by Gabriela Perković, Josipa Martinović, Gordana Šelo, Ana Bucić-Kojić, Mirela Planinić and Rita Ambrus
Foods 2024, 13(9), 1346; https://doi.org/10.3390/foods13091346 (registering DOI) - 27 Apr 2024
Abstract
Both grape pomace and whey are waste products from the food industry that are rich in valuable ingredients. The utilization of these two by-products is becoming increasingly possible as consumer awareness of upcycling increases. The biological activities of grape pomace extract (GPE) are [...] Read more.
Both grape pomace and whey are waste products from the food industry that are rich in valuable ingredients. The utilization of these two by-products is becoming increasingly possible as consumer awareness of upcycling increases. The biological activities of grape pomace extract (GPE) are diverse and depend on its bioavailability, which is influenced by processes in the digestive system. In this work, goat whey protein (GW) was used as the primary coating to protect the phenolic compounds of GPE during the spray drying process. In addition, trehalose (T), sucrose (S), xylose (X), and maltodextrin (MD) were added to the goat whey proteins as co-coatings and protein stabilizers. All spray drying experiments resulted in microcapsules (MC) with a high encapsulation efficiency (77.6–95.5%) and yield (91.5–99.0%) and almost 100% recovery of phenolic compounds during the release test. For o-coumaric acid, the GW-coated microcapsules (MC) showed a bioavailability index of up to 731.23%. A semi-crystalline structure and hydrophilicity were characteristics of the MC coated with 10% T, S, X, or 5% MD. GW alone or in combination with T, S, MD, or X proved to be a promising carrier for polyphenols from grape pomace extract and ensured good bioavailability of these natural antioxidants. Full article
(This article belongs to the Section Food Engineering and Technology)
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11 pages, 294 KiB  
Article
The Impact of Diagnosis of Human Papillomavirus (HPV) Infection and Electrosurgical Excision Procedure (LEEP) for Cervical Intraepithelial Neoplasia 3 (CIN3) on Women’s Sexual Lives
by Maria Teresa Bruno, Giuseppe Caruso, Elena Torrisi, Raffaela Grimaldi, Biagio Abate, Francesco Saverio Luciani, Susanna Basile and Marco Marzio Panella
Diagnostics 2024, 14(9), 911; https://doi.org/10.3390/diagnostics14090911 (registering DOI) - 27 Apr 2024
Abstract
The aim of the study was to assess sexual health in women who underwent Loop Electrosurgical Excisional Procedure (LEEP) for the treatment of cervical intraepithelial neoplasia 3 (CIN 3). One hundred thirty-one women were enrolled, and the Female Sexual Function Index (FSFI) questionnaire [...] Read more.
The aim of the study was to assess sexual health in women who underwent Loop Electrosurgical Excisional Procedure (LEEP) for the treatment of cervical intraepithelial neoplasia 3 (CIN 3). One hundred thirty-one women were enrolled, and the Female Sexual Function Index (FSFI) questionnaire was administered before LEEP and 6 months after the procedure. In almost all of the participants, data revealed a statistically significant worsening in sexual quality of life after LEEP. Therefore, clinicians should be aware of these possible negative effects on sexual behavior, and provide women with appropriate, wide-ranging, and detailed counseling. The data obtained in the present study should help to plan appropriate counseling from communicating HPV diagnosis and medical treatment to CIN3 surgical procedure. Full article
(This article belongs to the Section Diagnostic Microbiology and Infectious Disease)
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18 pages, 732 KiB  
Article
Absorption and Fluorescence Emission Investigations on Supramolecular Assemblies of Tetrakis-(4-sulfonatophenyl)porphyrin and Graphene Quantum Dots
by Mariachiara Sarà, Salvatore Vincenzo Giofrè, Salvatore Abate, Mariachiara Trapani, Rosaria Verduci, Giovanna D’Angelo, Maria Angela Castriciano, Andrea Romeo, Giovanni Neri and Luigi Monsù Scolaro
Molecules 2024, 29(9), 2015; https://doi.org/10.3390/molecules29092015 (registering DOI) - 27 Apr 2024
Abstract
The one-pot synthesis of N-doped graphene quantum dots (GQDs), capped with a positively charged polyamine (trien), has been realized through a microwave-assisted pyrolysis on solid L-glutamic acid and trien in equimolar amounts. The resulting positively charged nanoparticles are strongly emissive in aqueous solutions [...] Read more.
The one-pot synthesis of N-doped graphene quantum dots (GQDs), capped with a positively charged polyamine (trien), has been realized through a microwave-assisted pyrolysis on solid L-glutamic acid and trien in equimolar amounts. The resulting positively charged nanoparticles are strongly emissive in aqueous solutions and are stable for months. The interaction with the anionic tetrakis(4-sulphonatophenyl)porphyrin (TPPS4) has been investigated at neutral and mild acidic pH using a combination of UV/vis absorption spectroscopy together with static and time-resolved fluorescence emission. At pH = 7, the experimental evidence points to the formation of a supramolecular adduct mainly stabilized by electrostatic interactions. The fluorescence emission of the porphyrin is substantially quenched while GQDs remain still emissive. On decreasing the pH, protonation of TPPS4 leads to formation of porphyrin J-aggregates through the intermediacy of the charged quantum dots. Full article
(This article belongs to the Section Physical Chemistry)
24 pages, 1059 KiB  
Article
Studies on the Thermal Decomposition Course of Nitrogen-Rich Heterocyclic Esters as Potential Drug Candidates and Evaluation of Their Thermal Stability and Properties
by Marta Worzakowska, Krzysztof Sztanke and Małgorzata Sztanke
Int. J. Mol. Sci. 2024, 25(9), 4768; https://doi.org/10.3390/ijms25094768 (registering DOI) - 27 Apr 2024
Abstract
Drug candidates must undergo thermal evaluation as early as possible in the preclinical phase of drug development because undesirable changes in their structure and physicochemical properties may result in decreased pharmacological activity or enhanced toxicity. Hence, the detailed evaluation of nitrogen-rich heterocyclic esters [...] Read more.
Drug candidates must undergo thermal evaluation as early as possible in the preclinical phase of drug development because undesirable changes in their structure and physicochemical properties may result in decreased pharmacological activity or enhanced toxicity. Hence, the detailed evaluation of nitrogen-rich heterocyclic esters as potential drug candidates, i.e., imidazolidinoannelated triazinylformic acid ethyl esters 13 (where R1 = 4–CH3 or 4–OCH3 or 4–Cl, and R2 = –COOC2H5) and imidazolidinoannelated triazinylacetic acid methyl esters 46 (where R1 = 4–CH3 or 4–OCH3 or 4–Cl, and R2 = –CH2COOCH3)—in terms of their melting points, melting enthalpy values, thermal stabilities, pyrolysis, and oxidative decomposition course—has been carried out, using the simultaneous thermal analysis methods (TG/DTG/DSC) coupled with spectroscopic techniques (FTIR and QMS). It was found that the melting process (documented as one sharp peak related to the solid–liquid phase transition) of the investigated esters proceeded without their thermal decomposition. It was confirmed that the melting points of the tested compounds increased in relation to R1 and R2 as follows: 2 (R1 = 4–OCH3; R2 = –COOC2H5) < 6 (R1 = 4–Cl; R2 = –CH2COOCH3) < 5 (R1 = 4–OCH3; R2 = –CH2COOCH3) < 3 (R1 = 4–Cl; R2 = –COOC2H5) < 1 (R1 = 4–CH3; R2 = –COOC2H5) < 4 (R1 = 4–CH3; R2 = –CH2COOCH3). All polynitrogenated heterocyclic esters proved to be thermally stable up to 250 °C in inert and oxidising conditions, although 13 were characterised by higher thermal stability compared to 46. The results confirmed that both the pyrolysis and the oxidative decomposition of heterocyclic ethyl formates/methyl acetates with para-substitutions at the phenyl moiety proceed according to the radical mechanism. In inert conditions, the pyrolysis process of the studied molecules occurred with the homolytic breaking of the C–C, C–N, and C–O bonds. This led to the emission of alcohol (ethanol in the case of 13 or methanol in the case of 46), NH3, HCN, HNCO, aldehydes, CO2, CH4, HCl, aromatics, and H2O. In turn, in the presence of air, cleavage of the C–C, C–N, and C–O bonds connected with some oxidation and combustion processes took place. This led to the emission of the corresponding alcohol depending on the analysed class of heterocyclic esters, NH3, HCN, HNCO, aldehydes, N2, NO/NO2, CO, CO2, HCl, aromatics, and H2O. Additionally, after some biological tests, it was proven that all nitrogen-rich heterocyclic esters—as potential drug candidates—are safe for erythrocytes, and some of them are able to protect red blood cells from oxidative stress-induced damage. Full article
(This article belongs to the Special Issue Techniques and Strategies in Drug Design and Discovery, 2nd Edition)
15 pages, 7380 KiB  
Article
Preparation of a Polymeric Phosphoramide Flame-Retardant and Its Effect on the Flame-Retardant Properties of Epoxy Resin
by Hao Wang, Yinjie Wang, Yan Su, Chuang Yu, Jia Han and Jiping Liu
Polymers 2024, 16(9), 1224; https://doi.org/10.3390/polym16091224 (registering DOI) - 27 Apr 2024
Abstract
The flammability of epoxy resins and knowing how to achieve curing are particularly important factors during use. A novel approach for enhancing the fire resistance and reducing the smoke emission of epoxy resin during the curing process is suggested, which involves the utilization [...] Read more.
The flammability of epoxy resins and knowing how to achieve curing are particularly important factors during use. A novel approach for enhancing the fire resistance and reducing the smoke emission of epoxy resin during the curing process is suggested, which involves the utilization of a three-source integrated polymerization intumescent flame-retardant. In this study, the synthesis of poly 4,4-diaminodiphenylsulfone spirocyclic pentaerythritol bisphosphonate (PCS) is achieved through using solution polymerization, utilizing 4,4′-diaminodiphenylsulfone (DDS) and spirocyclic pentaerythritol bisphosphorate disphosphoryl chloride (SPDPC) as initial components. Following that, the EP underwent the inclusion of PCS to examine its resistance to heat, its ability to prevent flames, its effectiveness in reducing smoke and its curing effect. Compared to the unmodified epoxy resin, the addition of PCS can not only cure the epoxy resin, but also decompose before the epoxy resin and has a good carbonization effect. With the addition of 7 wt.% PCS, the LOI value can achieve 31.2% and successfully pass the UL-94 test with a V-0 rating. Moreover, the cone calorimeter experiment demonstrated a noteworthy decline of 59.7% in the maximum heat release rate (pHRR), 63.7% in overall heat release (THR), and 42.3% in total smoke generation (TSP). Based on the examination of TG-FTIR and SEM findings, there is ample evidence to suggest that PCS, functioning as a phosphorus-nitrogen intumescent flame-retardant that combines three origins, has the potential to exhibit a favorable flame-retardant impact in both its gas and condensed phases. Full article
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19 pages, 4351 KiB  
Article
Advancing Urban Building Energy Modeling: Building Energy Simulations for Three Commercial Building Stocks through Archetype Development
by Md. Uzzal Hossain, Isabella Cicco and Melissa M. Bilec
Buildings 2024, 14(5), 1241; https://doi.org/10.3390/buildings14051241 (registering DOI) - 27 Apr 2024
Abstract
Urban building energy models (UBEMs), developed to understand the energy performance of building stocks of a region, can aid in key decisions related to energy policy and climate change solutions. However, creating a city-scale UBEM is challenging due to the requirements of diverse [...] Read more.
Urban building energy models (UBEMs), developed to understand the energy performance of building stocks of a region, can aid in key decisions related to energy policy and climate change solutions. However, creating a city-scale UBEM is challenging due to the requirements of diverse geometric and non-geometric datasets. Thus, we aimed to further elucidate the process of creating a UBEM with disparate and scarce data based on a bottom-up, physics-based approach. We focused on three typically overlooked but functionally important commercial building stocks, which are sales and shopping, healthcare facilities, and food sales and services, in the region of Pittsburgh, Pennsylvania. We harvested relevant local building information and employed photogrammetry and image processing. We created archetypes for key building types, designed 3D buildings with SketchUp, and performed an energy analysis using EnergyPlus. The average annual simulated energy use intensities (EUIs) were 528 kWh/m2, 822 kWh/m2, and 2894 kWh/m2 for sales and shopping, healthcare facilities, and food sales and services, respectively. In addition to variations found in the simulated energy use pattern among the stocks, considerable variations were observed within buildings of the same stock. About 9% and 11% errors were observed for sales and shopping and healthcare facilities when validating the simulated results with the actual data. The suggested energy conservation measures could reduce the annual EUI by 10–26% depending on the building use type. The UBEM results can assist in finding energy-efficient retrofit solutions with respect to the energy and carbon reduction goal for commercial building stocks at the city scale. The limitations highlighted may be considered for higher accuracy, and the UBEM has a high potential to integrate with urban climate and energy models, circular economy, and life cycle assessment for sustainable urban planning. Full article
(This article belongs to the Section Construction Management, and Computers & Digitization)
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24 pages, 16242 KiB  
Article
Investigation into the Failure Characteristics and Mechanism of Rock with Single Elliptical Defects under Ultrasonic Vibrations
by Zhijun Niu, Xufeng Wang, Lei Zhang, Jiyao Wang, Zechao Chang, Chenlong Qian and Xuyang Chen
Fractal Fract. 2024, 8(5), 261; https://doi.org/10.3390/fractalfract8050261 (registering DOI) - 27 Apr 2024
Abstract
In order to investigate the effects of elliptical defects on rock failure under ultrasonic vibrations, ultrasonic vibration tests and PFC2D numerical simulations were conducted on rocks with single elliptical defects. The research results indicated that the fracture fractal dimension, axial strain, and [...] Read more.
In order to investigate the effects of elliptical defects on rock failure under ultrasonic vibrations, ultrasonic vibration tests and PFC2D numerical simulations were conducted on rocks with single elliptical defects. The research results indicated that the fracture fractal dimension, axial strain, and crack depth of specimens with elliptical defects at 45° and 90° were the smallest and largest, respectively. The corresponding strain and fractal dimension showed a positive linear and logarithmic function relationship with time. The maximum crack depth of 46.50 mm was observed on the specimens with an elliptical defect angle of 90°. Specimens with elliptical defects at 0°, 30°, 75°, and 90° exhibited more dense and frequent acoustic emission events than those with elliptical defects at 15°, 45°, and 60°. During the ultrasonic vibration process, the maximum total energy (87.86 kJ) and energy consumption coefficient (0.963) were observed on specimens with elliptical defect angles of 30° and 45°, respectively. The difference in the stress field led to varying degrees of plastic strain energy in the specimens, resulting in different forms of crack propagation and triggering differential acoustic emission events, ultimately leading to specimen failure with different crack shapes and depths. The fractal dimensions of elliptical defect specimens under ultrasonic vibration have a high degree of consistency with the changes in axial strain and failure depth, and the fractal dimension of defect specimens is positively correlated with the degree of failure of defect specimens. Full article
(This article belongs to the Special Issue Applications of Fractal Analysis in Underground Engineering)
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21 pages, 4151 KiB  
Article
Formation Control of Multiple Autonomous Mobile Robots Using Turkish Natural Language Processing
by Kadir Aram, Gokhan Erdemir and Burhanettin Can
Appl. Sci. 2024, 14(9), 3722; https://doi.org/10.3390/app14093722 (registering DOI) - 27 Apr 2024
Abstract
People use natural language to express their thoughts and wishes. As robots reside in various human environments, such as homes, offices, and hospitals, the need for human–robot communication is increasing. One of the best ways to achieve this communication is the use of [...] Read more.
People use natural language to express their thoughts and wishes. As robots reside in various human environments, such as homes, offices, and hospitals, the need for human–robot communication is increasing. One of the best ways to achieve this communication is the use of natural languages. Natural language processing (NLP) is the most important approach enabling robots to understand natural languages and improve human–robot interaction. Also, due to this need, the amount of research on NLP has increased considerably in recent years. In this study, commands were given to a multiple-mobile-robot system using the Turkish natural language, and the robots were required to fulfill these orders. Turkish is classified as an agglutinative language. In agglutinative languages, words combine different morphemes, each carrying a specific meaning, to create complex words. Turkish exhibits this characteristic by adding various suffixes to a root or base form to convey grammatical relationships, tense, aspect, mood, and other semantic nuances. Since the Turkish language has an agglutinative structure, it is very difficult to decode its sentence structure in a way that robots can understand. Parsing of a given command, path planning, path tracking, and formation control were carried out. In the path-planning phase, the A* algorithm was used to find the optimal path, and a PID controller was used to follow the generated path with minimum error. A leader–follower approach was used to control multiple robots. A platoon formation was chosen as the multi-robot formation. The proposed method was validated on a known map containing obstacles, demonstrating the system’s ability to navigate the robots to the desired locations while maintaining the specified formation. This study used Turtlebot3 robots within the Gazebo simulation environment, providing a controlled and replicable setting for comprehensive experimentation. The results affirm the feasibility and effectiveness of employing NLP techniques for the formation control of multiple mobile robots, offering a robust and effective method for further research and development on human–robot interaction. Full article
(This article belongs to the Special Issue Natural Language Processing: Trends and Challenges)
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12 pages, 620 KiB  
Article
Sex Disparity in the Association of Metabolic Syndrome with Cognitive Impairment
by Yi-Min Chang, Chia-Lin Lee and Jun-Sing Wang
J. Clin. Med. 2024, 13(9), 2571; https://doi.org/10.3390/jcm13092571 (registering DOI) - 27 Apr 2024
Abstract
Background/Objectives: Metabolic syndrome (MS) is a constellation of several cardiometabolic risk factors. We investigated sex disparity in the associations between MS and cognitive impairment using cross-sectional data from Taiwan Biobank. Methods: We determined the associations of MS and its five components with cognitive [...] Read more.
Background/Objectives: Metabolic syndrome (MS) is a constellation of several cardiometabolic risk factors. We investigated sex disparity in the associations between MS and cognitive impairment using cross-sectional data from Taiwan Biobank. Methods: We determined the associations of MS and its five components with cognitive impairment (mini-mental state examination, MMSE < 24) and the five domains of MMSE using logistic regression analyses. Results: A total of 7399 men and 11,546 women were included, and MS was significantly associated with cognitive impairment only in women (adjusted OR 1.48, 95% CI 1.29–1.71, p = 0.001) (p for interaction 0.005). In women, the association with MS was significant in orientation (adjusted OR 1.21, 95% CI 1.07–1.37, p = 0.003), memory (adjusted OR 1.12, 95% CI 1.01–1.25, p = 0.034) and design copying (adjusted OR 1.41, 95% CI 1.23–1.62, p = 0.001) (p value for interaction 0.039, 0.023, and 0.093, respectively). Among the components of MS, a large waist circumference (adjusted OR 1.25, 95% CI 1.08–1.46, p = 0.003), high fasting glucose (adjusted OR 1.16, 95% CI 1.00–1.34, p = 0.046), and low HDL cholesterol (adjusted OR 1.16, 95% CI 1.00–1.34, p = 0.049) were significantly associated with cognitive impairment in women. Conclusions: Our findings suggest that sex has a significant influence on the association between MS and cognitive dysfunction, especially in orientation and memory. Full article
(This article belongs to the Section Endocrinology & Metabolism)
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25 pages, 917 KiB  
Article
Adoption of Green Mark Criteria toward Construction Management Sustainability
by Hai Chien Pham, Vu Hong Son Pham and Trong Kich Than
Buildings 2024, 14(5), 1242; https://doi.org/10.3390/buildings14051242 (registering DOI) - 27 Apr 2024
Abstract
Sustainable construction plays a significant role in developing countries. However, the adoption of sustainable buildings has faced diverse challenges. Therefore, this research investigates the benefits and challenges of adopting the Green Mark in green building projects. After a literature review and a pilot [...] Read more.
Sustainable construction plays a significant role in developing countries. However, the adoption of sustainable buildings has faced diverse challenges. Therefore, this research investigates the benefits and challenges of adopting the Green Mark in green building projects. After a literature review and a pilot study with construction experts, an industry-wide survey was conducted to collect 148 valid responses. The data were analyzed in depth, with 24 barriers and 10 benefits, using the Statistical Package for the Social Science (SPSS) software. After this, the collected data were analyzed using the analytic hierarchy process (AHP) method to prioritize critical factors. The preliminary findings revealed significant practical implications and offered valuable insights to support the adoption of Green Mark criteria for construction management sustainability. Furthermore, practical solutions were proposed to foster the widespread adoption of green buildings toward sustainable construction in the future. Full article
17 pages, 5837 KiB  
Article
A Comparison of Different Biomass Combustion Mechanisms in the Transient State
by Filipe Neves, Armando A. Soares and Abel Rouboa
Energies 2024, 17(9), 2092; https://doi.org/10.3390/en17092092 (registering DOI) - 27 Apr 2024
Abstract
Different combustion reaction process models were used to numerically study the behavior of the temperature, velocity, and turbulence fields, as well as to gain a better understanding of the differences between the reaction products obtained with each model. Transient-state simulations were conducted for [...] Read more.
Different combustion reaction process models were used to numerically study the behavior of the temperature, velocity, and turbulence fields, as well as to gain a better understanding of the differences between the reaction products obtained with each model. Transient-state simulations were conducted for a gasifier under specific operating conditions. The standard K-epsilon (2eq) turbulence model was utilized, along with the incorporation of species transport, volumetric responses, and eddy dissipation. In this study, the impacts of one-, two-, and four-step reaction mechanisms on the mass fraction of the products of the reactions, as well as the maximum values of velocity, turbulence, and temperature, were examined. The findings demonstrated that for all mechanisms, the greater maximum values of velocity and turbulence are attained at early time steps and decrease with subsequent time steps. The temperature rises as much in the early time steps and nearly stays the same in the late time steps. In all situations examined, the species’ fraction mass varies slightly in the early time steps but becomes nearly constant in the latter time stages. Similar species mass fraction values were found for both one-step and four-step methods. The results also suggest that the lower half of the gasifier is where the highest mass fraction values are found. Full article
(This article belongs to the Section A4: Bio-Energy)
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18 pages, 2603 KiB  
Article
Physiological, Transcriptome, and Metabolome Analyses Reveal the Tolerance to Cu Toxicity in Red Macroalgae Gracilariopsis lemaneiformis
by Xiaojiao Chen, Yueyao Tang, Hao Zhang, Xiaoqian Zhang, Xue Sun, Xiaonan Zang and Nianjun Xu
Int. J. Mol. Sci. 2024, 25(9), 4770; https://doi.org/10.3390/ijms25094770 (registering DOI) - 27 Apr 2024
Abstract
Heavy metal copper (Cu) will inevitably impact the marine macroalgae Gracilariopsis lemaneiformis (G. lemaneiformis), which is a culture of economic importance along China’s coastline. In this study, the detoxification mechanism of Cu stress on G. lemaneiformis was revealed by assessing physiological [...] Read more.
Heavy metal copper (Cu) will inevitably impact the marine macroalgae Gracilariopsis lemaneiformis (G. lemaneiformis), which is a culture of economic importance along China’s coastline. In this study, the detoxification mechanism of Cu stress on G. lemaneiformis was revealed by assessing physiological indicators in conjunction with transcriptome and metabolome analyses at 1 d after Cu stress. Our findings revealed that 25 μM Cu stimulated ROS synthesis and led to the enzymatic oxidation of arachidonic acid residues. This process subsequently impeded G. lemaneiformis growth by suppressing photosynthesis, nitrogen metabolism, protein synthesis, etc. The entry of Cu ions into the algae was facilitated by ZIPs and IRT transporters, presenting as Cu2+. Furthermore, there was an up-regulation of Cu efflux transporters HMA5 and ABC family transporters to achieve compartmentation to mitigate the toxicity. The results revealed that G. lemaneiformis elevated the antioxidant enzyme superoxide dismutase and ascorbate-glutathione cycle to maintain ROS homeostasis. Additionally, metabolites such as flavonoids, 3-O-methylgallic acid, 3-hydroxy-4-keto-gama-carotene, and eicosapentaenoic acid were up-regulated compared with the control, indicating that they might play roles in response to Cu stress. In summary, this study offers a comprehensive insight into the detoxification mechanisms driving the responses of G. lemaneiformis to Cu exposure. Full article
(This article belongs to the Special Issue Advance in Plant Abiotic Stress)
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14 pages, 538 KiB  
Article
The Relationship between miR-5682 and Nutritional Status of Radiotherapy-Treated Male Laryngeal Cancer Patients
by Marcin Mazurek, Anna Brzozowska, Mirosław Maziarz, Teresa Małecka-Massalska and Tomasz Powrózek
Genes 2024, 15(5), 556; https://doi.org/10.3390/genes15050556 (registering DOI) - 27 Apr 2024
Abstract
Background: Nutritional deficiencies are frequently observed in patients with head and neck cancer (HNC) undergoing radiation therapy. microRNAs (miRNAs) were found to play an important role in the development of metabolic disorders throughout regulation of genes involved in inflammatory responses. This study aimed [...] Read more.
Background: Nutritional deficiencies are frequently observed in patients with head and neck cancer (HNC) undergoing radiation therapy. microRNAs (miRNAs) were found to play an important role in the development of metabolic disorders throughout regulation of genes involved in inflammatory responses. This study aimed to explore the correlation between pre-treatment miR-5682 expression and parameters reflecting nutritional deficits in laryngeal cancer (LC) patients subjected to radiotherapy (RT). Methods: Expression of miR-5682 was analyzed in plasma samples of 56 male LC individuals. Nutritional status of LC patients was assessed using anthropometric and laboratory parameters, bioelectrical impedance analysis (BIA) and clinical questionnaires. Results: A high expression of miR-5682 was associated with significantly lower values of BMI, fat mass, fat-free mass and plasma albumin at selected periods of RT course. miR-5682 allowed us to distinguish between patients classified with both SGA-C and low albumin level from other LC patients with 100% sensitivity and 69.6% specificity (AUC = 0.820; p < 0.0001). Higher expression of studied miRNA was significantly associated with shorter median overall survival (OS) in LC patients (HR = 2.26; p = 0.008). Conclusions: analysis of miR-5682 expression demonstrates a potential clinical utility in selection of LC patients suffering from nutritional deficiencies developing as a consequence of RT-based therapy. Full article
(This article belongs to the Special Issue Non-coding RNAs in Human Health and Disease)
10 pages, 618 KiB  
Systematic Review
Plasma Exchange in Anti-Signal Recognition Particle Myopathy: A Systematic Review and Combined Analysis of Patient Individual Data
by Pablo Martínez-Rodríguez, María Escribano-Iglesias, Ángel-P. Crisolino-Pozas, Noelia Cubino-Boveda, Miriam López-Parra, Miguel Marcos and Antonio-J. Chamorro
J. Pers. Med. 2024, 14(5), 461; https://doi.org/10.3390/jpm14050461 (registering DOI) - 27 Apr 2024
Abstract
Anti-signal recognition particle myopathy (anti-SRP myopathy) is a rare subtype of immune-mediated inflammatory myopathy characterized by muscle weakness and anti-SRP autoantibodies. Although plasma exchange (PE) is used in severe cases, its role remains unclear. A systematic review was conducted following PRISMA guidelines, identifying [...] Read more.
Anti-signal recognition particle myopathy (anti-SRP myopathy) is a rare subtype of immune-mediated inflammatory myopathy characterized by muscle weakness and anti-SRP autoantibodies. Although plasma exchange (PE) is used in severe cases, its role remains unclear. A systematic review was conducted following PRISMA guidelines, identifying 23 patients with anti-SRP myopathy treated with PE. Data on demographics, clinical features, laboratory findings, treatments, and outcomes were analyzed combining individual patient data if available. Sixteen (69.6%) patients were male, with muscle weakness as the predominant symptom in 100% of cases. After PE, most patients showed improvement in symptoms, and the proportion of patients with muscle weakness was reduced (p = 0.001). Relapse occurred in 17.4% of the cases. The incidence of adverse events was low (8.7%). Despite limitations, including a small sample size and heterogeneous data, our systematic review suggests that PE may be effective in inducing remission and controlling symptoms in anti-SRP myopathy, particularly in severe cases. Since evidence on PE in anti-SRP myopathy is limited, further research, including prospective multicenter studies, is warranted to understand better its efficacy and safety and establish its role in treatment algorithms. Full article
(This article belongs to the Special Issue Clinical Decisions in Connective Tissue Disease)
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21 pages, 637 KiB  
Article
Function-Level Compilation Provenance Identification with Multi-Faceted Neural Feature Distillation and Fusion
by Yang Gao, Lunjin Liang, Yifei Li, Rui Li and Yu Wang
Electronics 2024, 13(9), 1692; https://doi.org/10.3390/electronics13091692 (registering DOI) - 27 Apr 2024
Abstract
In the landscape of software development, the selection of compilation tools and settings plays a pivotal role in the creation of executable binaries. This diversity, while beneficial, introduces significant challenges for reverse engineers and security analysts in deciphering the compilation provenance of binary [...] Read more.
In the landscape of software development, the selection of compilation tools and settings plays a pivotal role in the creation of executable binaries. This diversity, while beneficial, introduces significant challenges for reverse engineers and security analysts in deciphering the compilation provenance of binary code. To this end, we present MulCPI, short for Multi-representation Fusion-based Compilation Provenance Identification, which integrates the features collected from multiple distinct intermediate representations of the binary code for better discernment of the fine-grained function-level compilation details. In particular, we devise a novel graph-oriented neural encoder improved upon the gated graph neural network by subtly introducing an attention mechanism into the neighborhood nodes’ information aggregation computation, in order to better distill the more informative features from the attributed control flow graph. By further integrating the features collected from the normalized assembly sequence with an advanced Transformer encoder, MulCPI is capable of capturing a more comprehensive set of features manifesting the multi-faceted lexical, syntactic, and structural insights of the binary code. Extensive evaluation on a public dataset comprising 854,858 unique functions demonstrates that MulCPI exceeds the performance of current leading methods in identifying the compiler family, optimization level, compiler version, and the combination of compilation settings. It achieves average accuracy rates of 99.3%, 96.4%, 90.7%, and 85.3% on these tasks, respectively. Additionally, an ablation study highlights the significance of MulCPI’s core designs, validating the efficiency of the proposed attention-enhanced gated graph neural network encoder and the advantages of incorporating multiple code representations. Full article
(This article belongs to the Special Issue Machine Learning (ML) and Software Engineering, Volume II)
15 pages, 504 KiB  
Review
Dietary Phenolic Compounds—Wellbeing and Perspective Applications
by Dasha Mihaylova, Maria Dimitrova-Dimova and Aneta Popova
Int. J. Mol. Sci. 2024, 25(9), 4769; https://doi.org/10.3390/ijms25094769 (registering DOI) - 27 Apr 2024
Abstract
Contemporary living is continuously leading to poor everyday choices resulting in the manifestation of various diseases. The benefits of plant-based nutrition are undeniable and research on the topic is rising. Modern man is now aware of the possibilities that plant nutrition can provide [...] Read more.
Contemporary living is continuously leading to poor everyday choices resulting in the manifestation of various diseases. The benefits of plant-based nutrition are undeniable and research on the topic is rising. Modern man is now aware of the possibilities that plant nutrition can provide and is seeking ways to benefit from it. Dietary phenolic compounds are among the easily accessible beneficial substances that can exhibit antioxidant, anti-inflammatory, antitumor, antibacterial, antiviral, antifungal, antiparasitic, analgesic, anti-diabetic, anti-atherogenic, antiproliferative, as well as cardio-and neuroprotective activities. Several industries are exploring ways to incorporate biologically active substances in their produce. This review is concentrated on presenting current information about the dietary phenolic compounds and their contribution to maintaining good health. Additionally, this content will demonstrate the importance and prosperity of natural compounds for various fields, i.e., food industry, cosmetology, and biotechnology, among others. Full article
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18 pages, 15335 KiB  
Article
LanCL2 Implicates in Testicular Redox Homeostasis and Acrosomal Maturation
by Yanling Zhao, Jichen Wang, Shuai Shi, Xinting Lan, Xiangyu Cheng, Lixia Li, Yuanfeng Zou, Lanlan Jia, Wentao Liu, Qihui Luo, Zhengli Chen and Chao Huang
Antioxidants 2024, 13(5), 534; https://doi.org/10.3390/antiox13050534 (registering DOI) - 27 Apr 2024
Abstract
Redox balance plays an important role in testicular homeostasis. While lots of antioxidant molecules have been identified as widely expressed, the understanding of the critical mechanisms for redox management in male germ cells is inadequate. This study identified LanCL2 as a major male [...] Read more.
Redox balance plays an important role in testicular homeostasis. While lots of antioxidant molecules have been identified as widely expressed, the understanding of the critical mechanisms for redox management in male germ cells is inadequate. This study identified LanCL2 as a major male germ cell-specific antioxidant gene that is important for testicular homeostasis. Highly expressed in the brain and testis, LanCL2 expression correlates with testicular maturation and brain development. LanCL2 is enriched in spermatocytes and round spermatids of the testis. By examining LanCL2 knockout mice, we found that LanCL2 deletion did not affect postnatal brain development but injured the sperm parameters of adult mice. With histopathological analysis, we noticed that LanCL2 KO caused a pre-maturation and accelerated the self-renewal of spermatogonial stem cells in the early stage of spermatogenesis. In contrast, at the adult stage, LanCL2 KO damaged the acrosomal maturation in spermiogenesis, resulting in spermatogenic defects with a reduced number and motility of spermatozoa. Furthermore, we show that this disruption of testicular homeostasis in the LanCL2 KO testis was due to dysbalanced testicular redox homeostasis. This study demonstrates the critical role of LanCL2 in testicular homeostasis and redox balance. Full article
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18 pages, 2150 KiB  
Article
Analysis and Interpretation of Automated Blood Count in the Treatment of Chronic Paracoccidioidomycosis
by Eliana da Costa Alvarenga de Brito, Adriana de Oliveira França, Igor Valadares Siqueira, Vinícius Lopes Teodoro Félix, Amanda Alves Rezende, Bárbara Casella Amorim, Suzane Eberhart Ribeiro da Silva, Rinaldo Poncio Mendes, Simone Schneider Weber and Anamaria Mello Miranda Paniago
J. Fungi 2024, 10(5), 317; https://doi.org/10.3390/jof10050317 (registering DOI) - 27 Apr 2024
Abstract
Blood count is crucial for assessing bone marrow’s cell production and differentiation during infections, gaging disease severity, and monitoring therapeutic responses. The profile of blood count in chronic forms of paracoccidioidomycosis (PCM) has been insufficiently explored. To better understand the changes in hematological [...] Read more.
Blood count is crucial for assessing bone marrow’s cell production and differentiation during infections, gaging disease severity, and monitoring therapeutic responses. The profile of blood count in chronic forms of paracoccidioidomycosis (PCM) has been insufficiently explored. To better understand the changes in hematological cells in different stages of the PCM chronic form, we evaluated the blood count, including immature blood cells in automated equipment, before and during the treatment follow-up of 62 chronic PCM patients. Predominantly male (96.8%) with an average age of 54.3 (standard deviation SD 6.9) years, participants exhibited pre-treatment conditions such as anemia (45.2%), monocytosis (38.7%), and leukocytosis (17.7%), which became less frequent after clinical cure. Anemia was more prevalent in severe cases. Notably, hemoglobin and reticulocyte hemoglobin content increased, while leukocytes, monocytes, neutrophils, immature granulocytes, and platelets decreased. Chronic PCM induced manageable hematological abnormalities, mainly in the red blood series. Monocytosis, indicating monocytes’ role in PCM’s immune response, was frequent. Post-treatment, especially after achieving clinical cure, significant improvements were observed in various hematological indices, including immature granulocytes and reticulocyte hemoglobin content, underscoring the impact of infection on these parameters. Full article
(This article belongs to the Special Issue New Insights into Paracoccidioides and Paracoccidioidomycosis)
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11 pages, 785 KiB  
Article
Coronary Calcium Is Elevated in Patients with Myocardial Infarction without Standard Modifiable Risk Factors
by Jeffrey L. Anderson, Stacey Knight, Li Dong, Heidi T. May, Viet T. Le, Tami L. Bair and Kirk U. Knowlton
J. Clin. Med. 2024, 13(9), 2569; https://doi.org/10.3390/jcm13092569 (registering DOI) - 27 Apr 2024
Abstract
Objectives: Recent reports have highlighted myocardial infarction (MI) patients without standard modifiable risk factors (SMRF), noting them to be surprisingly common and to have a substantial risk of adverse outcomes. The objective of this study was to address the challenge of identifying [...] Read more.
Objectives: Recent reports have highlighted myocardial infarction (MI) patients without standard modifiable risk factors (SMRF), noting them to be surprisingly common and to have a substantial risk of adverse outcomes. The objective of this study was to address the challenge of identifying at-risk patients without SMRF and providing preventive therapy. Methods: Patients presenting between 2001 and 2021 to Intermountain Health catheterization laboratories with a diagnosis of MI were included if they also had a coronary artery calcium (CAC) scan by computed tomography within 2 years. SMRF were defined as a clinical diagnosis or treatment of hypertension, hyperlipidemia, diabetes, or smoking. The co-primary endpoints in SMRF-less patients were: (1) proportion of patients with an elevated (>50%ile) CAC score, and (2) an indication for statin therapy (i.e., CAC ≥ 100 AU or ≥75%ile). The 60-day and long-term major adverse cardiovascular events were determined. A comparison set included MI patients with SMRF. Results: We identified 429 MI patients with a concurrent CAC scan, of which 60 had no SMRF. SMRF status did not distinguish most risk factors or interventions. No-SMRF patients had a high CAC prevalence and percentile (82% ≥ 50%ile; median, 80%ile), and 77% met criteria for preventive therapy. As expected, patients with SMRF had high CAC scores and percentiles. Outcomes were more favorable for No-SMRF status and for lower CAC scores. Conclusions: Patients without SMRF presenting with an MI have a high prevalence and percentile of CAC. Wider application of CAC scans, including in those without SMRF, is promising as a method to identify an additional at-risk population for MI and to provide primary preventive therapy. Full article
(This article belongs to the Section Cardiology)
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15 pages, 3236 KiB  
Article
Numerical Simulation of the Mixing and Salt Washing Effects of a Static Mixer in an Electric Desalination Process
by Yuhang Liu, Mengmeng Gao, Zibin Huang, Hongfu Wang, Peiqing Yuan, Xinru Xu and Jingyi Yang
Processes 2024, 12(5), 883; https://doi.org/10.3390/pr12050883 (registering DOI) - 27 Apr 2024
Abstract
Electric desalination units in the crude oil refining process are becoming increasingly important with the growing trend towards heavy and poor crude oils. The oil–water mixing effect of the static mixer plays a crucial role in the electric desalination process. The present study [...] Read more.
Electric desalination units in the crude oil refining process are becoming increasingly important with the growing trend towards heavy and poor crude oils. The oil–water mixing effect of the static mixer plays a crucial role in the electric desalination process. The present study investigated the effect of various variables, such as mixer type, number of mixing elements, washing water consumption, and oil viscosity and density on the oil–water mixing efficiency of a static mixer. In addition, this study also analyzed the effect of these variables on the salt washing process that occurs during mixing using a kinetic equation for the dissolution of inorganic salts. The results showed that the number of mixing elements was the most significant variable, followed by the amount of washing water injected. The density of the crude oil had a negligible effect. Based on these results, the use of four mixing elements in the SMX static mixer was recommended. The injection of washing water should be controlled at about 8%, while ensuring that the interfacial tension between oil and water remains below 0.01 N/m. Under these conditions, the salt washing efficiency reached 46.3%. This study provides a theoretical basis for designing static mixers and optimizing their operation in electric desalination processes. Full article
(This article belongs to the Section Separation Processes)
18 pages, 3544 KiB  
Review
Detecting DC Electrical Resistivity Changes in Seismic Active Areas: State-of-the-Art and Future Directions
by Vincenzo Lapenna
Geosciences 2024, 14(5), 118; https://doi.org/10.3390/geosciences14050118 (registering DOI) - 27 Apr 2024
Abstract
In this paper, a critical review of the geoelectrical monitoring activities carried out in seismically active areas is presented and discussed. The electrical resistivity of rocks is one of the geophysical parameters of greatest interest in the study of possible seismic precursors, and [...] Read more.
In this paper, a critical review of the geoelectrical monitoring activities carried out in seismically active areas is presented and discussed. The electrical resistivity of rocks is one of the geophysical parameters of greatest interest in the study of possible seismic precursors, and it is strongly influenced by the presence of highly fractured zones with high permeability and fluid levels. The analysis in the present study was carried out on results obtained over the last 50 years in seismic zones in China, Japan, the USA and Russia. These past works made it possible to classify the different monitoring strategies, analyze the theoretical models for interpreting possible correlations between anomalies in resistivity signals and local seismicity, and identify the main scientific and technological gaps in the literature. In addition, great attention has been paid to some recent works on the study of the correlations between focal mechanisms and the shapes of anomalous patterns in resistivity time series. Finally, some future scenarios for the development of new activities in this field have been identified. Full article
(This article belongs to the Special Issue Precursory Phenomena Prior to Earthquakes 2023)
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