The 2023 MDPI Annual Report has
been released!
 
15 pages, 2398 KiB  
Article
Improvement in Facial Wrinkles Using Materials Enhancing PPARGC1B Expression Related to Mitochondrial Function
by Hyejin Lee, Sanghyun Ye, Juhyun Kim, Seung-Hyun Jun and Nae-Gyu Kang
Curr. Issues Mol. Biol. 2024, 46(6), 5037-5051; https://doi.org/10.3390/cimb46060302 (registering DOI) - 21 May 2024
Abstract
Skin aging is an unavoidable natural phenomenon caused by intrinsic and extrinsic factors. In modern society, the pursuit of a wrinkle-free and aesthetically appealing face has gained considerable prominence. Numerous studies have aimed at mitigating the appearance of facial wrinkles. Antiaging research focused [...] Read more.
Skin aging is an unavoidable natural phenomenon caused by intrinsic and extrinsic factors. In modern society, the pursuit of a wrinkle-free and aesthetically appealing face has gained considerable prominence. Numerous studies have aimed at mitigating the appearance of facial wrinkles. Antiaging research focused on regulating the function of mitochondria, the main reactive oxygen species-generating organelles, has been extensively conducted. In this study, we investigated the correlation between facial wrinkles and the expression of PPARGC1B, considering the association of this gene with mitochondrial function, to identify its potential as a target for exploring antiaging cosmetic materials. We elucidated the role of PPARGC1B in the skin and identified five bioactive materials that modulated its expression. The effectiveness of these materials was verified through in vitro experiments on human dermal fibroblasts. We prepared cosmetic formulations incorporating the five materials and confirmed their ability to enhance dermal collagen in three-dimensional skin models and reduce facial wrinkles under the eyes and nasolabial fold areas in human subjects. The study findings have significant implications for developing novel antiaging cosmetic formulations by reinforcing mitochondrial functions. Full article
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
Show Figures

Figure 1

14 pages, 14701 KiB  
Article
Design and Experiments of the Data Acquisition System for Bale Rolling Characteristic Parameters on a Large-Scale Round Bale Machine
by Junyue Wang, Fandi Zeng, Ji Cui, Hongbin Bai, Xuying Li and Zhihuan Zhao
Processes 2024, 12(6), 1042; https://doi.org/10.3390/pr12061042 (registering DOI) - 21 May 2024
Abstract
The parameters of the roll characteristics of a large-scale round bale machine were collected in real time to investigate the bale rolling mechanism. This investigation develops a set of adaptable and highly integrated data acquisition systems for the bale rolling performance parameters of [...] Read more.
The parameters of the roll characteristics of a large-scale round bale machine were collected in real time to investigate the bale rolling mechanism. This investigation develops a set of adaptable and highly integrated data acquisition systems for the bale rolling performance parameters of large-type round bale machines. A rolling experiment is conducted using sunflower straw as the material, and the power consumption and radial tension of the roller-round bale machine during the bale rolling process are studied. In the grass core formation stage, the round bale machine’s torque need was minimal, the radial tension of the bale remained nearly constant, and the bale chamber was primarily filled with loose sunflower straw. The motor torque and the straw bale’s radial tension both showed a tendency of gradual increase when the round bale machine was in the grass-filling stage. The motor torque and bale radial tension displayed a roughly linear trend of rapid rise as the sunflower straw continued to enter the rolling bale chamber; this was when the round bale machine was in the compressed bale rolling stage. When the power consumption of the round bale machine was measured using the data acquisition system during the test bench empty run and core-creation stage, the energy consumption comparison analysis produced a relative error of 5.8%. During the stage of bale rolling and compression, the data acquisition system monitored the power consumption of the round bale machine. The relative error was 9.5%. The data acquisition system of the round bale machine test bed has an accuracy of 90.5%–94.2% when measuring the machine’s power consumption, indicating that it is a stable and efficient system. This study provides a foundation for further research on intelligent the roller-round bale machine. Full article
Show Figures

Figure 1

17 pages, 39975 KiB  
Article
A Hybrid Learning-Architecture for Improved Brain Tumor Recognition
by Jose Dixon, Oluwatunmise Akinniyi, Abeer Abdelhamid, Gehad A. Saleh, Md Mahmudur Rahman and Fahmi Khalifa
Algorithms 2024, 17(6), 221; https://doi.org/10.3390/a17060221 (registering DOI) - 21 May 2024
Abstract
The accurate classification of brain tumors is an important step for early intervention. Artificial intelligence (AI)-based diagnostic systems have been utilized in recent years to help automate the process and provide more objective and faster diagnosis. This work introduces an enhanced AI-based architecture [...] Read more.
The accurate classification of brain tumors is an important step for early intervention. Artificial intelligence (AI)-based diagnostic systems have been utilized in recent years to help automate the process and provide more objective and faster diagnosis. This work introduces an enhanced AI-based architecture for improved brain tumor classification. We introduce a hybrid architecture that integrates vision transformer (ViT) and deep neural networks to create an ensemble classifier, resulting in a more robust brain tumor classification framework. The analysis pipeline begins with preprocessing and data normalization, followed by extracting three types of MRI-derived information-rich features. The latter included higher-order texture and structural feature sets to harness the spatial interactions between image intensities, which were derived using Haralick features and local binary patterns. Additionally, local deeper features of the brain images are extracted using an optimized convolutional neural networks (CNN) architecture. Finally, ViT-derived features are also integrated due to their ability to handle dependencies across larger distances while being less sensitive to data augmentation. The extracted features are then weighted, fused, and fed to a machine learning classifier for the final classification of brain MRIs. The proposed weighted ensemble architecture has been evaluated on publicly available and locally collected brain MRIs of four classes using various metrics. The results showed that leveraging the benefits of individual components of the proposed architecture leads to improved performance using ablation studies. Full article
(This article belongs to the Special Issue Algorithms for Computer Aided Diagnosis)
Show Figures

Figure 1

20 pages, 2041 KiB  
Review
Phytonanotherapy for the Treatment of Metabolic Dysfunction-Associated Steatotic Liver Disease
by Livhuwani P. Nendouvhada, Nicole R. S. Sibuyi, Adewale O. Fadaka, Samantha Meyer, Abram M. Madiehe, Mervin Meyer and Kwazikwakhe B. Gabuza
Int. J. Mol. Sci. 2024, 25(11), 5571; https://doi.org/10.3390/ijms25115571 (registering DOI) - 21 May 2024
Abstract
Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as nonalcoholic fatty liver disease, is a steatotic liver disease associated with metabolic syndrome (MetS), especially obesity, hypertension, diabetes, hyperlipidemia, and hypertriglyceridemia. MASLD in 43–44% of patients can progress to metabolic dysfunction-associated steatohepatitis (MASH), and [...] Read more.
Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as nonalcoholic fatty liver disease, is a steatotic liver disease associated with metabolic syndrome (MetS), especially obesity, hypertension, diabetes, hyperlipidemia, and hypertriglyceridemia. MASLD in 43–44% of patients can progress to metabolic dysfunction-associated steatohepatitis (MASH), and 7–30% of these cases will progress to liver scarring (cirrhosis). To date, the mechanism of MASLD and its progression is not completely understood and there were no therapeutic strategies specifically tailored for MASLD/MASH until March 2024. The conventional antiobesity and antidiabetic pharmacological approaches used to reduce the progression of MASLD demonstrated favorable peripheral outcomes but insignificant effects on liver histology. Alternatively, phyto-synthesized metal-based nanoparticles (MNPs) are now being explored in the treatment of various liver diseases due to their unique bioactivities and reduced bystander effects. Although phytonanotherapy has not been explored in the clinical treatment of MASLD/MASH, MNPs such as gold NPs (AuNPs) and silver NPs (AgNPs) have been reported to improve metabolic processes by reducing blood glucose levels, body fat, and inflammation. Therefore, these actions suggest that MNPs can potentially be used in the treatment of MASLD/MASH and related metabolic diseases. Further studies are warranted to investigate the feasibility and efficacy of phytonanomedicine before clinical application. Full article
Show Figures

Figure 1

10 pages, 214 KiB  
Review
Gastrointestinal Perforation with Blunt Abdominal Trauma in Children
by Victoriya Staab, Srividya Naganathan, Margaret McGuire, Jamie M. Pinto and Harpreet Pall
Children 2024, 11(6), 612; https://doi.org/10.3390/children11060612 (registering DOI) - 21 May 2024
Abstract
Gastrointestinal tract perforation is uncommon in children, accounting for <10% of cases of blunt abdominal trauma. Diagnosis of bowel perforation in children can be challenging due to poor diagnostic imaging accuracy. Intra-abdominal free air is found only in half of the children with [...] Read more.
Gastrointestinal tract perforation is uncommon in children, accounting for <10% of cases of blunt abdominal trauma. Diagnosis of bowel perforation in children can be challenging due to poor diagnostic imaging accuracy. Intra-abdominal free air is found only in half of the children with bowel perforation. Ultrasound findings are nonspecific and suspicious for perforation in only two-thirds of cases. A computer tomography (CT) scan has a sensitivity and specificity of 50% and 95%, respectively. Surgical decisions should be made based on clinical examination despite normal CT results. Management of bowel perforation in children includes primary repair in 50–70% and resection with anastomosis in 20–40% of cases. Full article
(This article belongs to the Special Issue Advances in Gastrointestinal Surgery in Children)
16 pages, 5855 KiB  
Article
High-Performance Materials Improve the Early Shrinkage, Early Cracking, Strength, Impermeability, and Microstructure of Manufactured Sand Concrete
by Mingming Zhang, Shan Gao, Tong Liu, Shuyu Guo and Shuotian Zhang
Materials 2024, 17(10), 2465; https://doi.org/10.3390/ma17102465 - 20 May 2024
Abstract
The poor early shrinkage and cracking performances of manufactured sand concrete, waste powder concrete, and recycled aggregate concrete are the main difficulties in engineering applications. To solve these problems, early shrinkage and cracking, strength, and impermeability tests were performed on high-volume stone powder [...] Read more.
The poor early shrinkage and cracking performances of manufactured sand concrete, waste powder concrete, and recycled aggregate concrete are the main difficulties in engineering applications. To solve these problems, early shrinkage and cracking, strength, and impermeability tests were performed on high-volume stone powder manufactured sand concrete mixed with fly ash and slag powder (FS), a shrinkage-reducing agent (SRA), polyvinyl alcohol (PVA) fibers, and a superabsorbent polymer (SAP). Furthermore, the microstructures and pore structures of these concretes were revealed using nuclear magnetic resonance (NMR) and scanning electron microscopy (SEM). The results showed that the mixture of FS, SRA, PVA fibers, and SAP could effectively inhibit the shrinkage strain and cracking area of the concrete. The effect of the SAP on reducing the early shrinkage of the concrete is the greatest, and the shrinkage strain can be reduced by 76.49%. The PVA fibers had the most obvious effect on inhibiting the early cracking of the concrete, and the total cracking area was reduced by 66.91%. Significantly, the incorporation of the FS can improve the particle gradation and the pore structure and improve its compactness. The PVA fibers not only provide good carriers for cement-based materials but also enhance the bonding force between the particles inside the concrete, filling the pores inside the concrete, inhibiting the loss of water, and reducing the generation of internal microcracks. The FS and PVA can reduce the shrinkage and cracking risk and improve the strength and impermeability of the concrete. Although the SRA and SAP can reduce the shrinkage and cracking risks, it will lead to a significant decrease in the later strength and impermeability. The main reason is that the SRA leads to an increase in micropores in the matrix and microcracks near the aggregate, which are not conducive to the development of the strength and penetration resistance of the MS. Similarly, the SAP can promote the rapid formation of ettringite (Aft) at an early age and improve the early shrinkage, early cracking, and early strength of the concrete. However, with an increase in age, the residual pores, after SAP dehydration, will cause the deterioration of the concrete pore structure, resulting in the deterioration of the strength and impermeability. Full article
Show Figures

Figure 1

23 pages, 4288 KiB  
Article
Annona squamosa Fruit Extract Ameliorates Lead Acetate-Induced Testicular Injury by Modulating JAK-1/STAT-3/SOCS-1 Signaling in Male Rats
by Maysa A. Mobasher, Alaa Muqbil Alsirhani, Maha Abdullah Alwaili, Fadi Baakdah, Thamir M Eid, Fahad A. Alshanbari, Reem Yahya Alzahri, Sahar Abdulrahman Alkhodair and Karim Samy El-Said
Int. J. Mol. Sci. 2024, 25(10), 5562; https://doi.org/10.3390/ijms25105562 (registering DOI) - 20 May 2024
Abstract
Lead (Pb) is a common pollutant that is not biodegradable and gravely endangers the environment and human health. Annona squamosa fruit has a wide range of medicinal uses owing to its phytochemical constituents. This study evaluated the effect of treatment with A. squamosa [...] Read more.
Lead (Pb) is a common pollutant that is not biodegradable and gravely endangers the environment and human health. Annona squamosa fruit has a wide range of medicinal uses owing to its phytochemical constituents. This study evaluated the effect of treatment with A. squamosa fruit extract (ASFE) on testicular toxicity induced in male rats by lead acetate. The metal-chelating capacity and phytochemical composition of ASFE were determined. The LD50 of ASFE was evaluated by probit analysis. Molecular docking simulations were performed using Auto Dock Vina. Forty male Sprague Dawley rats were equally divided into the following groups: Gp1, a negative control group; Gp2, given ASFE (350 mg/kg body weight (b. wt.)) (1/10 of LD50); Gp3, given lead acetate (PbAc) solution (100 mg/kg b. wt.); and Gp4, given PbAc as in Gp3 and ASFE as in Gp2. All treatments were given by oro-gastric intubation daily for 30 days. Body weight changes, spermatological parameters, reproductive hormone levels, oxidative stress parameters, and inflammatory biomarkers were evaluated, and molecular and histopathological investigations were performed. The results showed that ASFE had promising metal-chelating activity and phytochemical composition. The LD50 of ASFE was 3500 mg/kg b. wt. The docking analysis showed that quercetin demonstrated a high binding affinity for JAK-1 and STAT-3 proteins, and this could make it a more promising candidate for targeting the JAK-1/STAT-3 pathway than others. The rats given lead acetate had defective testicular tissues, with altered molecular, biochemical, and histological features, as well as impaired spermatological characteristics. Treatment with ASFE led to a significant mitigation of these dysfunctions and modulated the JAK-1/STAT-3/SOCS-1 axis in the rats. Full article
(This article belongs to the Section Biochemistry)
Show Figures

Figure 1

14 pages, 4555 KiB  
Article
Three-Dimensional Upper Bound Solution to Estimate Soil Thrust of a Track System on Saturated Clay Slopes under Undrained Conditions
by Sehee Shin and Sang Inn Woo
Appl. Sci. 2024, 14(10), 4335; https://doi.org/10.3390/app14104335 (registering DOI) - 20 May 2024
Abstract
This study proposes a three-dimensional upper bound solution for estimating the soil thrust of tracked vehicles on saturated clay slopes. The present study considered block, triangular wedge, and trapezoidal wedge failure modes to formulate an upper bound solution for each. The analytical solution [...] Read more.
This study proposes a three-dimensional upper bound solution for estimating the soil thrust of tracked vehicles on saturated clay slopes. The present study considered block, triangular wedge, and trapezoidal wedge failure modes to formulate an upper bound solution for each. The analytical solution for soil thrust was determined as the minimum upper bound solution among those for each failure mode. This analytical solution was validated through numerical simulations that modeled track-ground interactions. Parametric studies, based on the upper bound solution, assessed the impact of track system shape, vehicle weight, undrained shear strength, and ground slope on soil thrust. The analytical solutions and parametric studies provide a rapid method for assessing vehicle operability on clay slopes and offer references for designing tracked vehicles suitable for site conditions. Full article
(This article belongs to the Special Issue Advances in Failure Mechanism and Numerical Methods for Geomaterials)
Show Figures

Figure 1

22 pages, 4294 KiB  
Review
Advances in Materials with Self-Healing Properties: A Brief Review
by Rashid Dallaev
Materials 2024, 17(10), 2464; https://doi.org/10.3390/ma17102464 - 20 May 2024
Abstract
The development of materials with self-healing capabilities has garnered considerable attention due to their potential to enhance the durability and longevity of various engineering and structural applications. In this review, we provide an overview of recent advances in materials with self-healing properties, encompassing [...] Read more.
The development of materials with self-healing capabilities has garnered considerable attention due to their potential to enhance the durability and longevity of various engineering and structural applications. In this review, we provide an overview of recent advances in materials with self-healing properties, encompassing polymers, ceramics, metals, and composites. We outline future research directions and potential applications of self-healing materials (SHMs) in diverse fields. This review aims to provide insights into the current state-of-the-art in SHM research and guide future efforts towards the development of innovative and sustainable materials with enhanced self-repair capabilities. Each material type showcases unique self-repair mechanisms tailored to address specific challenges. Furthermore, this review investigates crack healing processes, shedding light on the latest developments in this critical aspect of self-healing materials. Through an extensive exploration of these topics, this review aims to provide a comprehensive understanding of the current landscape and future directions in self-healing materials research. Full article
Show Figures

Figure 1

13 pages, 2497 KiB  
Article
Investigation of the Strain–Stress Field in Nanoscale Multilayer Systems by the Phase Plane Method
by Dmitrii Belous, Anna Badalyan, Alexei Khomenko and Alexander Goncharov
Materials 2024, 17(10), 2466; https://doi.org/10.3390/ma17102466 - 20 May 2024
Abstract
This paper presents the results of the study of stress relaxation fields, deformation, and temperature of the system of nanostructured multilayer coatings. In the work, a nonlinear relationship between strain and stress was used to take into account nonlinear effects in the mechanism [...] Read more.
This paper presents the results of the study of stress relaxation fields, deformation, and temperature of the system of nanostructured multilayer coatings. In the work, a nonlinear relationship between strain and stress was used to take into account nonlinear effects in the mechanism of nanostructure formation. The paper assumes that a friction surface is provided by the self-organization of shear components: both stress and strain on the one hand, and temperature on the other. The studied objects are described in the adiabatic approximation, taking into account the fact of the evolution of stresses and strains. With the help of phase portraits of the system, the dependence of the deformation processes on the stresses arising in the system without coating and with coating is shown. It is shown that the rate of change of deformation depends on the characteristics of the mechanical impact on the coating and on the amount of stress and deformation. A conclusion is drawn regarding the transition process in the presence of two regions (Hooke and plastic deformation) in the corresponding phase portrait of the strain–stress field of the system. The results of the work can be used to determine the effective parameters of a coating in the analysis of experimental time dependences of stresses. Full article
Show Figures

Figure 1

19 pages, 12395 KiB  
Article
Refined Aircraft Positioning Based on Stochastic Hybrid Estimation with Adaptive Square-Root Unscented Particle Filtering
by Yangyang Zhang, Zhenxing Gao, Kai Qi and Jiawei Li
Aerospace 2024, 11(5), 413; https://doi.org/10.3390/aerospace11050413 - 20 May 2024
Abstract
The positioning of civil aviation aircraft relative to a geographic reference point on Earth in a Cartesian frame is significant to detect the deviations from the desired path, especially for high-altitude airports or special airports based on performance-based navigation (PBN). To obtain these [...] Read more.
The positioning of civil aviation aircraft relative to a geographic reference point on Earth in a Cartesian frame is significant to detect the deviations from the desired path, especially for high-altitude airports or special airports based on performance-based navigation (PBN). To obtain these critical deviations during aircraft approach and landing, it is fundamental to estimate the continuous flight variables and discrete flight modes simultaneously with enough accuracy. With the coordinate conversion between the North, East, and Down (NED) frame and the geographic coordinate system based on World Geodetic System 1984 (WGS-84) considered, this study proposed a non-linear stochastic hybrid estimation algorithm with adaptive square-root unscented particle filtering (ASR-UPF) to estimate the true path. The probabilities of mode transition, represented by the normal cumulative density function of continuous states, determine whether to proceed with mode transitions. In addition, the adaptive update characterized by tracking variable noise and the importance sampling distributions based on the results of square-root unscented Kalman filtering (SR-UKF), as a comparative study of continuous system filtering, were used. The experiments illustrated the ASR-UPF is able to reduce the state estimation error more effectively, and more promptly track the error caused by incorrect mode estimation with adaptability compared to the SR-UKF. A further test with real flight data indicates that the proposed method gives the refined estimation of position and azimuth in NED frame. Full article
(This article belongs to the Section Aeronautics)
Show Figures

Figure 1

18 pages, 6592 KiB  
Review
A Primer for Utilizing Deep Learning and Abdominal MRI Imaging Features to Monitor Autosomal Dominant Polycystic Kidney Disease Progression
by Chenglin Zhu, Xinzi He, Jon D. Blumenfeld, Zhongxiu Hu, Hreedi Dev, Usama Sattar, Vahid Bazojoo, Arman Sharbatdaran, Mohit Aspal, Dominick Romano, Kurt Teichman, Hui Yi Ng He, Yin Wang, Andrea Soto Figueroa, Erin Weiss, Anna G. Prince, James M. Chevalier, Daniil Shimonov, Mina C. Moghadam, Mert Sabuncu and Martin R. Princeadd Show full author list remove Hide full author list
Biomedicines 2024, 12(5), 1133; https://doi.org/10.3390/biomedicines12051133 (registering DOI) - 20 May 2024
Abstract
Abdominal imaging of autosomal dominant polycystic kidney disease (ADPKD) has historically focused on detecting complications such as cyst rupture, cyst infection, obstructing renal calculi, and pyelonephritis; discriminating complex cysts from renal cell carcinoma; and identifying sources of abdominal pain. Many imaging features of [...] Read more.
Abdominal imaging of autosomal dominant polycystic kidney disease (ADPKD) has historically focused on detecting complications such as cyst rupture, cyst infection, obstructing renal calculi, and pyelonephritis; discriminating complex cysts from renal cell carcinoma; and identifying sources of abdominal pain. Many imaging features of ADPKD are incompletely evaluated or not deemed to be clinically significant, and because of this, treatment options are limited. However, total kidney volume (TKV) measurement has become important for assessing the risk of disease progression (i.e., Mayo Imaging Classification) and predicting tolvaptan treatment’s efficacy. Deep learning for segmenting the kidneys has improved these measurements’ speed, accuracy, and reproducibility. Deep learning models can also segment other organs and tissues, extracting additional biomarkers to characterize the extent to which extrarenal manifestations complicate ADPKD. In this concept paper, we demonstrate how deep learning may be applied to measure the TKV and how it can be extended to measure additional features of this disease. Full article
Show Figures

Figure 1

11 pages, 285 KiB  
Article
Alcohol-Based Chlorhexidine and Potassium Sorbate Rub Strengthens the Effectiveness of Traditional Hand Scrubbing and Improves Long-Lasting Effectiveness—Evaluation of Hand Preparation Protocols According to EN 12791
by Elena Herráiz Soria, Luis Alou, Carlos Martin-Villa, Ricardo Becerro-de-Bengoa-Vallejo, Marta Losa-Iglesias and David Sevillano
Antibiotics 2024, 13(5), 470; https://doi.org/10.3390/antibiotics13050470 - 20 May 2024
Abstract
Despite the advantages of surgical handrub in terms of the ease of application and effectiveness, chlorhexidine (CHG)-based hand scrubbing remains the preferred method for surgical hand preparation. However, it does not systematically meet the non-inferiority requirement of the European norm (EN) 12791 with [...] Read more.
Despite the advantages of surgical handrub in terms of the ease of application and effectiveness, chlorhexidine (CHG)-based hand scrubbing remains the preferred method for surgical hand preparation. However, it does not systematically meet the non-inferiority requirement of the European norm (EN) 12791 with respect to n-propanol (the reference product) and does not provide the sustained efficacy expected for these long-lasting agents. Commercially available alcohol-based products have also failed to demonstrate sustained efficacy according to EN 12791. Multi-step protocols enhance the efficacy of hand scrubbing, yet their extended disinfection duration might diminish their allure for healthcare professionals. In this study, we show that hand scrubbing with CHG 4% followed by a 1 min rubbing with the novel formulation of ethanol (Et) 70%/CHG 3% plus 0.3% potassium sorbate food additive (PS) meets the non-inferiority requirement and demonstrates sustained efficacy when tested according to EN 12791. The immediate and 3 h effect of this protocol was significantly higher than that of n-propanol and the homologous disinfection protocol without PS (CHG 4% hand scrub plus Et 70%/CHG 3% rub), demonstrating that the inclusion of PS confers a notable residual effect. We speculate that this non-volatile ingredient acts synergistically with CHG. This promising combination represents an alternative method for the development of new disinfection strategies. Full article
11 pages, 2797 KiB  
Communication
Sensing Characteristic Analysis of All-Dielectric Metasurfaces Based on Fano Resonance in Near-Infrared Regime
by Yongpeng Zhao, Qingfubo Geng, Jian Liu and Zhaoxin Geng
Photonics 2024, 11(5), 482; https://doi.org/10.3390/photonics11050482 (registering DOI) - 20 May 2024
Abstract
A novel, all-dielectric metasurface, featuring a missing wedge-shaped nanodisk, is proposed to investigate optical characteristics. By introducing symmetry-breaking to induce Fano resonance, the metasurface achieves an impressive Q-factor of 1202 in the near-infrared spectrum, with a remarkably narrow full width at half maximum [...] Read more.
A novel, all-dielectric metasurface, featuring a missing wedge-shaped nanodisk, is proposed to investigate optical characteristics. By introducing symmetry-breaking to induce Fano resonance, the metasurface achieves an impressive Q-factor of 1202 in the near-infrared spectrum, with a remarkably narrow full width at half maximum (FWHM) of less than 1 nm. The ability to adjust the wavelength resonance by manipulating the structure of the wedge-shaped nanodisk offers a simple and efficient approach for metasurface design. This breakthrough holds great potential for various applications in sensing and optical filtering, marking a significant advancement in the field of nanophotonics. Full article
(This article belongs to the Special Issue Advanced Photonic Sensing and Measurement II)
Show Figures

Figure 1

16 pages, 4039 KiB  
Article
A Soil Moisture and Vegetation-Based Susceptibility Mapping Approach to Wildfire Events in Greece
by Kyriakos Chaleplis, Avery Walters, Bin Fang, Venkataraman Lakshmi and Alexandra Gemitzi
Remote Sens. 2024, 16(10), 1816; https://doi.org/10.3390/rs16101816 (registering DOI) - 20 May 2024
Abstract
Wildfires in Mediterranean areas are becoming more frequent, and the fire season is extending toward the spring and autumn months. These alarming findings indicate an urgent need to develop fire susceptibility methods capable of identifying areas vulnerable to wildfires. The present work aims [...] Read more.
Wildfires in Mediterranean areas are becoming more frequent, and the fire season is extending toward the spring and autumn months. These alarming findings indicate an urgent need to develop fire susceptibility methods capable of identifying areas vulnerable to wildfires. The present work aims to uncover possible soil moisture and vegetation condition precursory signals of the largest and most devastating wildfires in Greece that occurred in 2021, 2022, and 2023. Therefore, the time series of two remotely sensed datasets–MAP L4 Soil Moisture (SM) and Landsat 8 NDVI, which represent vegetation and soil moisture conditions—were examined before five destructive wildfires in Greece during the study period. The results of the analysis highlighted specific properties indicative of fire-susceptible areas. NDVI in all fire-affected areas ranged from 0.13 to 0.35, while mean monthly soil moisture showed negative anomalies in the spring periods preceding fires. Accordingly, fire susceptibility maps were developed, verifying the usefulness of remotely sensed information related to soil moisture and NDVI. This information should be used to enhance fire models and identify areas at risk of wildfires in the near future. Full article
(This article belongs to the Special Issue Satellite Soil Moisture Estimation, Assessment, and Applications)
Show Figures

Figure 1

12 pages, 4988 KiB  
Case Report
A Clinical Approach for the Removal of a Large Antral Pseudocyst with Simultaneous Maxillary Sinus Augmentation: A Case Series
by Won-Bae Park, Jina Shin, Seungil Shin and Ji-Youn Hong
Medicina 2024, 60(5), 838; https://doi.org/10.3390/medicina60050838 (registering DOI) - 20 May 2024
Abstract
For a large benign lesion within the maxillary sinus, such as an antral pseudocyst, maxillary sinus floor augmentation is more commonly performed using a two-stage approach. This involves first removing the lesion, and then, re-entry following several months of healing. In this case [...] Read more.
For a large benign lesion within the maxillary sinus, such as an antral pseudocyst, maxillary sinus floor augmentation is more commonly performed using a two-stage approach. This involves first removing the lesion, and then, re-entry following several months of healing. In this case series, we described the “one-bony-window” approach, which is a technical surgical modification of the previous one-stage approach, for simultaneous cyst removal and maxillary sinus floor augmentation. Four patients with large maxillary antral pseudocysts were included. The “one-bony-window” approach involves the preparation of a large window opening of approximately 15 mm × 20 mm at the lateral wall. A mesiodistally extended intentional perforation was made in the upper part of the exposed membrane to enhance the access for instrumentation. The antral pseudocyst was removed in its entirety without being deformed to prevent rupture or leakage of the cystic contents. Subsequent detachment and elevation of the Schneiderian membrane at the sinus floor significantly reduced the perforation site, and bone grafting with implant placement was performed simultaneously. This alleviated the need to surgically repair the perforation. The lateral opening was either uncovered or repositioned using bony window lids. Healing abutments were connected after six months, and the final prosthesis was placed after two months. At the 1-year follow-up, the antral pseudocysts had resolved with no specific recurrence, and the stability of the augmented sinus was maintained with excellent implant survival. Within the limitations of our findings, the “one-bony-window” technique can be suggested for the simultaneous removal of large antral pseudocysts and maxillary sinus floor augmentation with favorable clinical outcomes. Full article
Show Figures

Figure 1

11 pages, 12320 KiB  
Article
Synergistic Therapy for Graves’ Ophthalmopathy-Associated Eyelid Retraction: Steroid, 5-FU, and Botulinum Neurotoxin a Combination
by Yuri Kim and Helen Lew
J. Clin. Med. 2024, 13(10), 3012; https://doi.org/10.3390/jcm13103012 (registering DOI) - 20 May 2024
Abstract
Background: Graves’ ophthalmopathy (GO) is characterized by upper eyelid retraction (UER), the most prevalent clinical sign. We aimed to assess the clinical efficacy of a multimodal combination of steroids, 5-fluorouracil (5-FU), and botulinum neurotoxin A (BoNT-A) injections in managing UER with GO and [...] Read more.
Background: Graves’ ophthalmopathy (GO) is characterized by upper eyelid retraction (UER), the most prevalent clinical sign. We aimed to assess the clinical efficacy of a multimodal combination of steroids, 5-fluorouracil (5-FU), and botulinum neurotoxin A (BoNT-A) injections in managing UER with GO and analyze the clinical factors in relation to the injection response. Methods: A total of 37 eyes from 23 patients were enrolled for UER with GO. At the endocrinology clinic, the patients were referred to the ophthalmology clinic after taking antithyroid medication for an average of 5.76 months (13 patients), while 10 patients were initially diagnosed with GO and referred to the endocrinology clinic for management of the thyroid hormone function. They performed an orbital computed tomography (CT) scan and measured the cross-sectional area of the orbit, orbital fat, and each extra ocular muscle (EOM) except for the inferior oblique muscle 4 mm behind the eyeball. Each of the EOMs and orbital fat were calculated as a ratio to the total orbit area. A total of 0.1 cc of triamcinolone (40 mg/mL), dexamethasone (5 mg/mL), 5-FU, and BoNT-A (2.5 units) was injected transconjunctivally. Medical records were examined and photographs were utilized to assess MRD1, inferior palpebral fissure (IPF), and lid lag during down gaze before and after the injection. The patients were divided into two groups: responders (more than 1 mm decrease in MRD1 after injection) and non-responders. During the follow-up period (11.0 ± 11.6 months), any potential adverse effects were monitored. Results: CAS decreased from 3.0 ± 0.8 to 1.4 ± 0.5 after the injection, and MRD1 decreased from 5.0 ± 0.9 mm to 4.5 ± 1.3 mm. Sixty percent of the patients were responders. Before and after the injection, the difference between IPF and MRD1 in responders was 0.60 ± 1.10 mm and 0.90 ± 0.90 mm, respectively, whereas, in non-responders, it was −0.57 ± 0.88 mm and −0.15 ± 0.75 mm, respectively. In the responders, pre-injection IPF and FT4 were significantly higher (p < 0.05). Responders had a larger EOM cross-sectional area (153.5 ± 18.0 mm2), including a larger lateral rectus muscle cross-sectional area (37.6 ± 9.7 mm2) than non-responders (132.0 ± 27.9 mm2; 29.1 ± 8.1 mm2). In responders, the treatment effect on IPF and MRD1 remained consistent at 1.2 ± 3.4 mm and 1.2 ± 1.6 mm, respectively, during the latest follow-up assessment. Conclusions: The combination injection of corticosteroids, 5-FU, and BoNT-A would be effective, especially, in patients with hyperthyroidism and an elongated IPF. Additionally, an increase in EOM cross-sectional area on CT, up to 150 mm2, may serve as an additional positive indicator for the use of multimodal injections in UER with GO. Full article
(This article belongs to the Section Ophthalmology)
Show Figures

Figure 1

18 pages, 364 KiB  
Article
Financial Literacy: A Case Study for Portugal
by Luís Almeida, João Chanoca and Fernando Tavares
J. Risk Financial Manag. 2024, 17(5), 215; https://doi.org/10.3390/jrfm17050215 (registering DOI) - 20 May 2024
Abstract
This work aims at understanding the level of financial literacy in Portugal, identifying the determinants of financial literacy in the Portuguese population, taking as an example certain sociodemographic factors such as gender and age. The aim is to understand whether there is a [...] Read more.
This work aims at understanding the level of financial literacy in Portugal, identifying the determinants of financial literacy in the Portuguese population, taking as an example certain sociodemographic factors such as gender and age. The aim is to understand whether there is a high level of adherence to financial literacy programs and initiatives, as well as the impact of financial knowledge variables on the financial literacy of the Portuguese population. The methodology used was quantitative and based on a questionnaire survey. The sample consisted of 600 individuals, all over 18 years old. It was concluded that individuals in the 26 to 35 age group had the best knowledge and that this sample showed better knowledge of interest rates compared to inflation and risk. The exploratory factor analysis shows five factors that determine the financial literacy of the Portuguese population and the way they manage their finances, which are (1) the perception of their current financial situation; (2) planning and controlling personal finances; (3) the perception of risky financial assets; (4) the perception of risk-free financial assets; and (5) savings. This research contributes to expanding scientific understanding in the field of financial literacy and offering support to the review of financial education policies by formulators, aiming to develop tools that help improve the financial behavior of the Portuguese population. Full article
(This article belongs to the Section Financial Markets)
12 pages, 6907 KiB  
Article
Flexible Nanofiber Pressure Sensors with Hydrophobic Properties for Wearable Electronics
by Yang Liu, Baoxiu Wang, Jiapeng Chen, Min Zhu and Zhenlin Jiang
Materials 2024, 17(10), 2463; https://doi.org/10.3390/ma17102463 - 20 May 2024
Abstract
In recent years, flexible pressure sensors have received considerable attention for their potential applications in health monitoring and human–machine interfaces. However, the development of flexible pressure sensors with excellent sensitivity performance and a variety of advantageous characteristics remains a significant challenge. In this [...] Read more.
In recent years, flexible pressure sensors have received considerable attention for their potential applications in health monitoring and human–machine interfaces. However, the development of flexible pressure sensors with excellent sensitivity performance and a variety of advantageous characteristics remains a significant challenge. In this paper, a high-performance flexible piezoresistive pressure sensor, BC/ZnO, is developed with a sensitive element consisting of bacterial cellulose (BC) nanofibrous aerogel modified by ZnO nanorods. The BC/ZnO pressure sensor exhibits excellent mechanical and hydrophobic properties, as well as a high sensitivity of −15.93 kPa−1 and a wide range of detection pressure (0.3–20 kPa), fast response (300 ms), and good cyclic durability (>1000). Furthermore, the sensor exhibits excellent sensing performance in real-time monitoring of a wide range of human behaviors, including mass movements and subtle physiological signals. Full article
(This article belongs to the Section Smart Materials)
Show Figures

Graphical abstract

50 pages, 3008 KiB  
Review
Unraveling the Microbiome–Human Body Axis: A Comprehensive Examination of Therapeutic Strategies, Interactions and Implications
by Gabriel Olteanu, Maria-Alexandra Ciucă-Pană, Ștefan Sebastian Busnatu, Dumitru Lupuliasa, Sorinel Marius Neacșu, Magdalena Mititelu, Adina Magdalena Musuc, Corina-Bianca Ioniță-Mîndrican and Steluța Constanța Boroghină
Int. J. Mol. Sci. 2024, 25(10), 5561; https://doi.org/10.3390/ijms25105561 - 20 May 2024
Abstract
This review scrutinizes the intricate interplay between the microbiome and the human body, exploring its multifaceted dimensions and far-reaching implications. The human microbiome, comprising diverse microbial communities inhabiting various anatomical niches, is increasingly recognized as a critical determinant of human health and disease. [...] Read more.
This review scrutinizes the intricate interplay between the microbiome and the human body, exploring its multifaceted dimensions and far-reaching implications. The human microbiome, comprising diverse microbial communities inhabiting various anatomical niches, is increasingly recognized as a critical determinant of human health and disease. Through an extensive examination of current research, this review elucidates the dynamic interactions between the microbiome and host physiology across multiple organ systems. Key topics include the establishment and maintenance of microbiota diversity, the influence of host factors on microbial composition, and the bidirectional communication pathways between microbiota and host cells. Furthermore, we delve into the functional implications of microbiome dysbiosis in disease states, emphasizing its role in shaping immune responses, metabolic processes, and neurological functions. Additionally, this review discusses emerging therapeutic strategies aimed at modulating the microbiome to restore host–microbe homeostasis and promote health. Microbiota fecal transplantation represents a groundbreaking therapeutic approach in the management of dysbiosis-related diseases, offering a promising avenue for restoring microbial balance within the gut ecosystem. This innovative therapy involves the transfer of fecal microbiota from a healthy donor to an individual suffering from dysbiosis, aiming to replenish beneficial microbial populations and mitigate pathological imbalances. By synthesizing findings from diverse fields, this review offers valuable insights into the complex relationship between the microbiome and the human body, highlighting avenues for future research and clinical interventions. Full article
(This article belongs to the Special Issue Gut Microbiota and Nutrition in Human Health)
Show Figures

Figure 1

19 pages, 2568 KiB  
Review
Advances in Endangered Plant Research: Ammopiptanthus’s Responses to Biotic and Abiotic Stressors
by Shuyao Wang, Shenghua Liang, Yahui Liu and Yingying Chen
Forests 2024, 15(5), 890; https://doi.org/10.3390/f15050890 (registering DOI) - 20 May 2024
Abstract
Ammopiptanthus, a unique evergreen broadleaf shrub endemic to the desert regions of Northwest China, exhibits a remarkable capacity for aeolian erosion control and dune stabilization. Attributed to its robust tolerance in terms of xerotolerance, halophytic adaptations, extreme thermotolerance, resistance to biotic and [...] Read more.
Ammopiptanthus, a unique evergreen broadleaf shrub endemic to the desert regions of Northwest China, exhibits a remarkable capacity for aeolian erosion control and dune stabilization. Attributed to its robust tolerance in terms of xerotolerance, halophytic adaptations, extreme thermotolerance, resistance to biotic and abiotic degradation and its defensive strategies against herbivory, Ammopiptanthus has emerged as an exemplary model organism for the study of plant resilience to diverse environmental stressors. Current research on Ammopiptanthus is scattered, lacking a systematic review, which poses a disadvantage for subsequent in-depth studies and the effective conservation of this endangered resource. In recent years, natural Ammopiptanthus communities have been severely disrupted, and the species’ natural range is rapidly shrinking. Here, this review summarizes the signaling pathways in the Ammopiptanthus response to biotic stress (especially the early signaling events), as well as the research advances in the resistance interactions between biotic and abiotic stresses. Then, the synergistic effects of multiple environmental pressures on Ammopiptanthus could be established, which may provide guidance for further studies on the resistance mechanism of Ammopiptanthus and be beneficial to its natural community protection and reconstruction. Full article
(This article belongs to the Special Issue Abiotic Stress in Tree Species)
Show Figures

Figure 1

19 pages, 15633 KiB  
Systematic Review
Dual-Task vs. Single-Task Gait Training to Improve Spatiotemporal Gait Parameters in People with Parkinson’s Disease: A Systematic Review and Meta-Analysis
by Elisabetta Sarasso, Marco Pietro Parente, Federica Agosta, Massimo Filippi and Davide Corbetta
Brain Sci. 2024, 14(5), 517; https://doi.org/10.3390/brainsci14050517 (registering DOI) - 20 May 2024
Abstract
Background: People with Parkinson’s disease (pwPD) present alterations of spatiotemporal gait parameters that impact walking ability. While preliminary studies suggested that dual-task gait training improves spatiotemporal gait parameters, it remains unclear whether dual-task gait training specifically improves dual-task gait performance compared to single-task [...] Read more.
Background: People with Parkinson’s disease (pwPD) present alterations of spatiotemporal gait parameters that impact walking ability. While preliminary studies suggested that dual-task gait training improves spatiotemporal gait parameters, it remains unclear whether dual-task gait training specifically improves dual-task gait performance compared to single-task gait training. The aim of this review is to assess the effect of dual-task training relative to single-task gait training on specific gait parameters during dual-task tests in pwPD. Methods: We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs), searching three electronic databases. Two reviewers independently selected RCTs, extracted data, and applied the Cochrane risk-of-bias tool for randomized trials (Version 2) and the GRADE framework for assessing the certainty of evidence. The primary outcomes were dual-task gait speed, stride length, and cadence. Secondary outcomes included dual-task costs on gait speed, balance confidence, and quality of life. Results: We included 14 RCTs (548 patients). Meta-analyses showed effects favoring dual-task training over single-task training in improving dual-task gait speed (standardized mean difference [SMD] = 0.48, 95% confidence interval [CI] = 0.20–0.77; 11 studies; low certainty evidence), stride length (mean difference [MD] = 0.09 m, 95% CI = 0.04–0.14; 4 studies; very low certainty evidence), and cadence (MD = 5.45 steps/min, 95% CI = 3.59–7.31; 5 studies; very low certainty evidence). We also found a significant effect of dual-task training over single-task training on dual-task cost and quality of life, but not on balance confidence. Conclusions: Our findings support the use of dual-task training relative to single-task training to improve dual-task spatiotemporal gait parameters in pwPD. Further studies are encouraged to better define the features of dual-task training and the clinical characteristics of pwPD to identify better responders. Full article
(This article belongs to the Special Issue Updates in Parkinson's Disease)
Show Figures

Figure 1

24 pages, 469 KiB  
Article
Time-Varying Function Matrix Projection Synchronization of Caputo Fractional-Order Uncertain Memristive Neural Networks with Multiple Delays via Mixed Open Loop Feedback Control and Impulsive Control
by Hongguang Fan, Yue Rao, Kaibo Shi and Hui Wen
Fractal Fract. 2024, 8(5), 301; https://doi.org/10.3390/fractalfract8050301 - 20 May 2024
Abstract
This paper shows solicitude for the generalized projective synchronization of Caputo fractional-order uncertain memristive neural networks (FOUMNNs) with multiple delays. By extending the constant scale factor to the time-varying function matrix, we establish an extraordinary synchronization mode called time-varying function matrix projection synchronization [...] Read more.
This paper shows solicitude for the generalized projective synchronization of Caputo fractional-order uncertain memristive neural networks (FOUMNNs) with multiple delays. By extending the constant scale factor to the time-varying function matrix, we establish an extraordinary synchronization mode called time-varying function matrix projection synchronization (TFMPS), which is a generalized version of traditional matrix projection synchronization, modified projection synchronization, complete synchronization, and anti-synchronization. To achieve the goal of TFMPS, we design a novel mixed controller including the open loop feedback control and impulsive control, which employs the state information in the time-delayed interval and the sampling information at the impulse instants. It has a prominent advantage that impulse intervals are not restricted by time delays. To establish the connection between the error system and the auxiliary system, a generalized fractional-order comparison theorem with time-varying coefficients and impulses is established. Applying the stability theory, the comparison theorem, and the Laplace transform, new synchronization criteria of FOUMNNs are acquired under the mixed impulsive control schemes, and the derived synchronization theorem and corollary can effectively expand the correlative synchronization achievements of fractional-order systems. Full article
Show Figures

Figure 1

Open Access Journals

Browse by Indexing Browse by Subject Selected Journals
Back to TopTop