Magnetization reduction roasting is an important method for the utilization of oolitic magnetite. In this study, the magnetization reduction behavior and kinetics of oolitic hematite in gas-based roasting were systematically investigated by X-ray photoelectron spectroscopy (XPS). The results revealed that under optimal roasting conditions of 650 °C, a roasting time of 60 min, and a CO concentration of 30%, the magnetization reduction rate of the roasted product reached 44.34%. Furthermore, the weak magnetic separation concentrate presented a TFe of 58.09% and a concentrate iron recovery of 94.3%. The results of the XPS spectrum indicated that the peak area ratio (Fe²⁺/Fe³⁺) gradually increased with an increase in roasting temperature, roasting time, and CO concentration, while over-reduction occurred when the roasting temperature exceeded 750 °C. The investigation of magnetization roasting kinetics for varying particle sizes demonstrated that the magnetization reduction process is controlled by chemical reaction, with a corresponding activation energy range of 42.96 kJ/mol to 63.29 kJ/mol, indicating the particle size has little effect on the magnetization reduction of oolitic hematite. Full article

Chronic myeloid leukemia (CML) is a hematopoietic stem cell disorder characterized by the presence of the Philadelphia chromosome, a product of the reciprocal translocation t(9;22)(q34;q11), in the BCR and ABL genes. These rearrangements in both genes lead to the formation of various fusion mRNA products, with preferential expression of b2a2, b3a2, and other BCR::ABL1 mRNA variants, combined with additional chromosomal abnormalities. Notably, the distribution and frequency of different mRNA variants vary in different populations. However, studies concerning this in Mexico are limited, and the results have been inconclusive. This study therefore aimed to determine the distribution of BCR::ABL1 mRNA variants in different clinical phases of CML and their effect on hematological parameters and patient survival. This study included 33 patients, whose demographic, clinical, and molecular data on BCR::ABL1 mRNA variants and hematological parameters were collected to identify potential associations. A total of 84.8% (n = 28) of patients had BCR::ABL1 translocation and increased platelet and basophil counts. The most frequent mRNA variant was b3a2 (64.3%), followed by b2a2 (28.6%) and e1a2 (3.6%). Concerning the clinical phases of CML, 75.8% (n = 25), 21.2% (n = 7), and 3% (n = 1) of patients were in the chronic, blast, and accelerated phases, respectively. Moreover, the b3a2 mRNA variant was more commonly identified in patients in the chronic phase. No correlation was observed between mRNA variant expression and patient survival. However, b2a2 was indicative of patients with longer survival as well as those treated with imatinib or nilotinib. Additionally, platelet count could be a marker of BCR::ABL1 translocation. Full article

The realization of a BRST cohomology of the 4D topological gauge-affine gravity is established in terms of a superconnection formalism. The identification of fields in the quantized theory occurs directly as is usual in terms of superconnection and its supercurvature components with the double covering of the general affine group $\overline{GA}(4,\mathbb{R})$. Then, by means of an appropriate decomposition of the metalinear double-covering group $\overline{SL}(5,\mathbb{R})$ with respect to the general linear double-covering group $\overline{GL}(4,\mathbb{R})$, one can easily obtain the enlargements of the fields while remaining consistent with the BRST algebra. This leads to the descent equations, allowing us to build the observables of the theory by means of the BRST algebra constructed using a $\overline{sa}(5,\mathbb{R})$ algebra-valued superconnection. In particular, we discuss the construction of topological invariants with torsion. Full article

Given the ever-changing world of technological advances, and due to the fact that business entities strive for efficiency and cost reduction, open innovation (OI) has become the focus of academic and scholarly discussions. Furthermore, to increase their competitiveness, small and medium enterprises (SMEs) have started implementing OI practices. This study aims to investigate the impact of SMEs’ internal organizational practices on OI and the impact of the latter on SMEs’ business performance. This quantitative study, which was based on gathering insights from SMEs, sought to answer two research questions related to the effects of organizational practices on the adoption and management of OI processes in SMEs and the role of OI in accelerating the business performance of SMEs. The findings revealed that not all SMEs’ internal organizational practices have a positive impact on both OI and SMEs’ business performance. This study is among the earliest studies in the UAE and GCC region to explore the impact of specific internal organizational practices on SME OI adoption and its business performance. The present study contributes theoretically and practically to OI literature and assists SME managers in evaluating their internal organizational practices’ suitability for OI adoption. Full article

Background: The periodization of physical exercise to optimize objectives is common in competitive sports. However, physical exercise programs for older adults only sometimes present periodization in their programming. Therefore, this article aims to research the results of applying the sports periodized method to older adults. Methods: A total of 137 participants over 60 years old performed a physical exercise program; 71 participated in a multi-component non-periodized program as the Control Group (CG), and 66 participated in a program periodized in blocks as the Experimental Group (EG). The block periodization program was oriented to the development of strength and was carried out in 86 sessions thrice weekly for eight months. Anthropometric assessments were made using weight, height, Body Mass Index, and electrical bioimpedance; and functional evaluations were made through standardized tests: Short Performance Physical Battery (SPPB), Timed Up & Go (TUG), handgrip, and a two-minute stair test. Results: After the intervention, the EG significantly improved TUG, weight, and BMI. On the other hand, the CG showed significant improvements in fat weight, BMI, and the 2 min stair test. The SPPB did not show changes after the intervention. Conclusion: The periodization of physical exercise for older adults does not significantly impact functional capacity in this population group. Full article

This paper reviews the dynamics of a single isotropic and homogeneous scalar field $\phi \left(t\right)$ in the context of cosmological models. A non-standard approach to the solution of the Einstein–Klein–Gordon equations is described which uses the scalar field as the evolution parameter for cosmic dynamics. General conclusions about the qualitative behaviour of the solutions can be drawn, and examples of how to obtain explicit solutions for some cosmological models of interest are given. For arbitrary potentials, analytical results can be obtained from the slow-roll approximation by using a series expansion for the Hubble parameter $H\left[\phi \right]$, from which a quantitative estimate for the number of e-folds of expansion is obtained. This approach is illustrated with the examples of quadratic potentials and hilltop models, with special consideration of Higgs-type potentials. The GUT-scale is shown to come out of such a model quite naturally. Finally, it is discussed how to find scalar potentials giving rise to a predetermined scalar-field behaviour and the associated evolution of the scale factor. Full article

In many (remote) rural areas of Europe and the world, rural communities are facing various challenges. One response is residents leaving their communities. However, there are also many empirical examples of residents staying, launching project initiatives, developing new solutions and experimenting with new practices. This is what we call social innovation. What experiences do actors have in these processes? Can we speak of empowerment? To what extent can such initiatives have an impact on community development? In this article, we explore these questions, for which there is little related empirical research. By applying a multi-sited individualising comparison to case studies in three European countries (Germany, Ireland and Portugal), we obtain empirical evidence of the following dimensions of empowerment that Avelino et al. outline conceptually: the achievement of autonomy, competence and relatedness and also impact, meaning and resilience. Often, however, it is not the individual actors for whom such effects can be reported. Rather, the social initiative as such or the local administration has acquired new skills and autonomy. Regarding community development, ‘pathways to impact’, such as infrastructure improvements and/or the creation of new employment opportunities and/or the influx of new residents, could be identified. However, this development often depended on both opportunity and the cooperation and goodwill of many stakeholders. Full article

Medical education acknowledges our need to teach our physicians about “social determinants of health” and “health care disparities”. However, educators often lack actionable training to address this need. We describe a faculty development activity, a health disparities journal club, using the jigsaw strategy with the intent of increasing awareness, encouraging self-directed learning, and inspiring future teaching of the subject to health professional learners. We completed six workshops at six individual hospitals, with 95 total attendees in medicine and numerous other health professions. Our evaluation asked trainees to: report the number of journal articles about health disparities they had read, excluding the assigned journal club articles, in the past 12 months, and to predict future plans for reading about health disparities. In total, 28.9% responded they had “never read” a prior article on health or healthcare disparities, while 54.2% responded “1–5 articles”. Many (60%) reported they would continue to investigate this topic. Our experience has demonstrated the utility and positive impact of a “flipped classroom” jigsaw method, showing it can be used successfully in Inter-Professional (IPE) Faculty Development to increase active exposure and discussion of the content. Additionally, this method promotes individual reflection and enhances continued collective engagement. Full article

This article attempts to answer the following question: why did the author of the apocryphon called 1 Apocryphal Apocalypse of John choose to efface himself and adopt John as his pseudonym? Why not Peter or Paul? This paper argues that the author of 1 Apocryphal Apocalypse of John intended to harness the audience attached to John, the seer of Revelation, by taking his name as a pseudonym. This paper sustains this claim by demonstrating that, in antiquity, each author had a specific pool of readers, often made out of friends and accolades of the author. Thus, authors’ names evoke an audience attached to them. When an author takes another person’s name to write under, he does so out of necessity, because he does not have an audience. But, when he takes another’s person name, he does so hoping to trick the audience of the impersonated into reading him. Based on this insight, this article concludes that the author of 1 Apocr. Apoc. John wanted the readers of canonical Revelation to engage with his work and that he achieved his purpose as evinced by the fact that the titles of both works share an uncanny resemblance, ranging from identical titles to similar wording. Since titles in antiquity were given to the works by their readers, the most logical explanation for canonical Revelation and 1 Apocr. Apoc. John having the same titles is that they both shared the same readers. Finally, this article argues that, in line with recent research on the use of pseudepigraphy in Jewish, Christian, and Roman contexts, the author of 1 Apocr. Apoc. John wanted to be read by CR’s readers because he wanted to expand, criticize, rework, and update CR’s eschatological discourse, exemplified by a close reading of how 1 Apocr. Apoc. John criticized, reworked, and updated CR’s presentation of the resurrection to bring it in harmony with late Christian reflection on the subject. Full article

Integrin α₄β₇+ T cells perpetuate tissue injury in chronic inflammatory diseases, yet their role in hepatic fibrosis progression remains poorly understood. Here, we report increased accumulation of α₄β₇+ T cells in the liver of people with cirrhosis relative to disease controls. Similarly, hepatic fibrosis in the established mouse model of CCl₄-induced liver fibrosis was associated with enrichment of intrahepatic α₄β₇+ CD4 and CD8 T cells. Monoclonal antibody (mAb)-mediated blockade of α₄β₇ or its ligand mucosal addressin cell adhesion molecule (MAdCAM)-1 attenuated hepatic inflammation and prevented fibrosis progression in CCl₄-treated mice. Improvement in liver fibrosis was associated with a significant decrease in the infiltration of α₄β₇+ CD4 and CD8 T cells, suggesting that α₄β₇/MAdCAM-1 axis regulates both CD4 and CD8 T cell recruitment to the fibrotic liver, and α₄β₇+ T cells promote hepatic fibrosis progression. Analysis of hepatic α₄β₇+ and α₄β₇- CD4 T cells revealed that α₄β₇+ CD4 T cells were enriched for markers of activation and proliferation, demonstrating an effector phenotype. The findings suggest that α₄β₇+ T cells play a critical role in promoting hepatic fibrosis progression, and mAb-mediated blockade of α₄β₇ or MAdCAM-1 represents a promising therapeutic strategy for slowing hepatic fibrosis progression in chronic liver diseases. Full article

Pancreatic cancer is one of the most aggressive, heterogeneous, and fatal types of human cancer; therefore, more effective therapeutic drugs are urgently needed. Human epidermal growth factor receptor 2 (HER2) overexpression and amplification have been identified as a cornerstone in this pathology. The aim of this review is to identify HER2 membrane overexpression in relation to pancreatic cancer pathways that can be used in order to develop a targeted therapy. After searching the keywords, 174 articles were found during a time span of 10 years, between 2013 and 2023, but only twelve scientific papers were qualified for this investigation. The new era of biomolecular research found a significant relationship between HER2 overexpression and pancreatic cancer cells in 25–30% of cases. The variables are dependent on tumor-derived cells, with differences in receptor overexpression between PDAC (pancreatic ductal adenocarcinoma), BTC (biliary tract cancer), ampullary carcinoma, and PNETs (pancreatic neuroendocrine tumors). HER2 overexpression is frequently encountered in human pancreatic carcinoma cell lines, and the ERBB family is one of the targets in the near future of therapy, with good results in phase I, II, and III studies evaluating downregulation and tumor downstaging, respectively. Full article

This study aimed to demonstrate the potential role of dual-energy CT in assessing bone mineral density (BMD) using hydroxyapatite–fat material pairing in postmenopausal women. A retrospective study was conducted on 51 postmenopausal female patients who underwent DXA and DECT examinations for other clinical reasons. DECT images were acquired with spectral imaging using a 256-slice system. These images were processed and visualized using a HAP–fat material pair. Statistical analysis was performed using the Bland–Altman method to assess the agreement between DXA and DECT HAP–fat measurements. Mean BMD, vertebral, and femoral T-scores were obtained. For vertebral analysis, the Bland–Altman plot showed an inverse correlation (R²: −0.042; RMSE: 0.690) between T-scores and DECT HAP–fat values for measurements from L1 to L4, while a good linear correlation (R²: 0.341; RMSE: 0.589) was found for measurements at the femoral neck. In conclusion, we demonstrate the enhanced importance of BMD calculation through DECT, finding a statistically significant correlation only at the femoral neck where BMD results do not seem to be influenced by the overlap of the measurements on cortical and trabecular bone. This outcome could be beneficial in the future by reducing radiation exposure for patients already undergoing follow-up for chronic conditions. Full article

Background: Aspergillus can cause fungal rhinosinusitis (FRS). We aimed to identify risk factors for sinonasal Aspergillus disease. Methods: Patients with a positive sinonasal mycological culture for Aspergillus species diagnosed in our hospital located in a continental climate were included in the 9-year retrospective study. Results: Of the 86 patients, 3 had invasive FRS (IFRS), 51 had fungal ball (FB) disease, and 32 had chronic rhinosinusitis with fungus (CFRS). In the IFRS group, all patients had a malignancy and were immunocompromised. Allergies, allergic rhinitis, asthma, nasal polyps, and the use of inhaled and nasal steroids were more common in the CFRS group, and IgE levels were greater than those in the FB and IRFS groups (p < 0.05). Conclusion: FB disease is a relatively symptom-free single-sinus disease among elderly individuals, and IFRS is dominant among immunocompromised patients. We discovered a third patient group, predominantly with nasal polyps, atopy, asthma, and elevated blood IgE and eosinophils, that did not fulfill the allergic FRS (AFRS) criteria. It is possible that a less fulminant category of underdiagnosed AFRS exists in cold climates. Treatment with local debridement is usually sufficient for FRS, apart from IFRS, and relapses are not common in cold climates. Full article

Immunoglobulin G-based monoclonal antibodies (mAbs) have been effective in treating various diseases, but their large molecular size can limit their penetration of tissue and efficacy in multifactorial diseases, necessitating the exploration of alternative forms. In this study, we constructed a phage display library comprising single-domain antibodies (sdAbs; or “VHHs”), known for their small size and remarkable stability, using a total of 1.6 × 10⁹ lymphocytes collected from 20 different alpacas, resulting in approximately 7.16 × 10¹⁰ colonies. To assess the quality of the constructed library, next-generation sequencing-based high-throughput profiling was performed, analyzing approximately 5.65 × 10⁶ full-length VHH sequences, revealing 92% uniqueness and confirming the library’s diverse composition. Systematic characterization of the library revealed multiple sdAbs with high affinity for three therapeutically relevant antigens. In conclusion, our alpaca sdAb phage display library provides a versatile resource for diagnostics and therapeutics. Furthermore, the library’s vast natural VHH antibody repertoire offers insights for generating humanized synthetic sdAb libraries, further advancing sdAb-based therapeutics. Full article

While FXR has shown promise in regulating bile acid synthesis and maintaining glucose and lipid homeostasis, undesired side effects have been observed in clinical trials. To address this issue, the development of intestinally restricted FXR modulators has gained attention as a new avenue for drug design with the potential for safer systematic effects. Our review examines all currently known intestinally restricted FXR ligands and provides insights into the steps taken to enhance intestinal selectivity. Full article

Unmanned aerial vehicles (UAVs) provide benefits through eco-friendliness, cost-effectiveness, and reduction of human risk. Deep reinforcement learning (DRL) is widely used for autonomous UAV navigation; however, current techniques often oversimplify the environment or impose movement restrictions. Additionally, most vision-based systems lack precise depth perception, while range finders provide a limited environmental overview, and LiDAR is energy-intensive. To address these challenges, this paper proposes VizNav, a modular DRL-based framework for autonomous UAV navigation in dynamic 3D environments without imposing conventional mobility constraints. VizNav incorporates the Twin Delayed Deep Deterministic Policy Gradient (TD3) algorithm with Prioritized Experience Replay and Importance Sampling (PER) to improve performance in continuous action spaces and mitigate overestimations. Additionally, VizNav employs depth map images (DMIs) to enhance visual navigation by accurately estimating objects’ depth information, thereby improving obstacle avoidance. Empirical results show that VizNav, by leveraging TD3, improves navigation, and the inclusion of PER and DMI further boosts performance. Furthermore, the deployment of VizNav across various experimental settings confirms its flexibility and adaptability. The framework’s architecture separates the agent’s learning from the training process, facilitating integration with various DRL algorithms, simulation environments, and reward functions. This modularity creates a potential to influence RL simulation in various autonomous navigation systems, including robotics control and autonomous vehicles. Full article

Due to the high mortality rate in Western countries, pancreatic cancer is considered one of the big killers, leaving patients and their families with little hope upon diagnosis. Although surgical and drug therapies are critical for cancer patients to improve life expectancy and alleviation of suffering, nutrition plays a key role in improving cancer treatment outcomes. This narrative review, conducted as part of the activities of the Italian Society of Human Nutrition (SINU) working group in oncology, focuses on the prevalence of vitamin malnutrition among pancreatic cancer patients. The results of the literature search show that pancreatic cancer patients are at a heightened risk of water-soluble vitamin deficiencies, particularly of vitamins B1, B3, and B6. Additionally, they also face an increased risk of deficiency of fat-soluble vitamins. Among these vitamins, the potential role of vitamin D in pancreatic cancer has garnered the most attention, with its plasma levels being identified as a significant factor in patient survival. Investigating vitamin nutritional status could provide valuable insights for incorporating nutritional approaches into the prevention and treatment of pancreatic cancer, thereby reducing the exacerbation of symptoms associated with the diagnosis. Full article

This paper works with functions defined in metric spaces and takes values in complete paranormed vector spaces or in Banach spaces, and proves some necessary and sufficient conditions for weak convergence of probability measures. Our main result is as follows: Let X be a complete paranormed vector space and $\Omega$ an arbitrary metric space, then a sequence $\left\{{\mu }_n\right\}$ of probability measures is weakly convergent to a probability measure $\mu$ if and only if $\underset{n\to \infty }{\lim }{\displaystyle {\int }_{\Omega }}g(s)d{\mu }_n={\displaystyle {\int }_{\Omega }}g(s)d\mu$ for every bounded continuous function g: Ω → X. A special case is as the following: if X is a Banach space, $\Omega$ an arbitrary metric space, then $\left\{{\mu }_n\right\}$ is weakly convergent to $\mu$ if and only if $\underset{n\to \infty }{\lim }{\displaystyle {\int }_{\Omega }}g(s)d{\mu }_n={\displaystyle {\int }_{\Omega }}g(s)d\mu$ for every bounded continuous function g: Ω → X. Our theorems and corollaries in the article modified or generalized some recent results regarding the convergence of sequences of measures. Full article

Prior research has suggested that resistance exercise may result in a temporary decrease in vascular function, as measured by flow-mediated dilation (FMD), among untrained young individuals. However, the immediate impact of combined elastic and weight resistance training on older adults remains insufficiently explored. We assessed vascular function before, after, and 30 min after acute exercise under three resistance conditions to evaluate whether a combination of weight and elastic resistance exercises has an acute effect on vascular function in older adults. Fourteen older adults (65.6 ± 2.9 years) executed three sets of 12 repetitions at 65% of one repetition maximum (1 RM) of the bench press (BP) exercise. Testing was performed on three separate days as follows: (1) barbell alone (BA); (2) barbell plus elastic bands (10% of 65% 1 RM) (BE10); and (3) barbell plus elastic bands (20% of 65% 1 RM) (BE20). A two-way (time × condition) repeated measures analysis of variance was employed to assess the time and condition effects on flow-mediated dilation (FMD) and pulse wave velocity (PWV). At 0 min post-exercise, FMD was significantly higher during BE10 than during BA (p < 0.05); however, at 30 min post-exercise, no significant difference (p ≥ 0.05) was observed between the three conditions. In each condition, FMD results did not differ significantly at different times (p ≥ 0.05). For FMD, the main effect of the condition (F[2,26] = 3.86, p = 0.034) and that of the time and condition (F[4,52] = 3.66, p = 0.011) were significant. For PWV, only the difference between the BA and BE10 conditions was significant at 0 min (p < 0.05). PWV increased from baseline in the BA condition (p < 0.05) but not significantly in the BE10 and BE20 conditions (p ≥ 0.05). Therefore, BA, BE10, and BE20 demonstrated various changes in vascular function. Long-term training intervention studies are needed to validate these findings. Full article

Neuroblastoma (NB) is the most commonly diagnosed extracranial solid tumor in children, accounting for 15% of all childhood cancer deaths. Although the 5-year survival rate of patients with a high-risk disease has increased in recent decades, NB remains a challenge in pediatric oncology, and the identification of novel potential therapeutic targets and agents is an urgent clinical need. The RNA-binding protein LIN28B has been identified as an oncogene in NB and is associated with a poor prognosis. Given that LIN28B acts by negatively regulating the biogenesis of the tumor suppressor let-7 miRNAs, we reasoned that selective interference with the LIN28B/let-7 miRNA interaction would increase let-7 miRNA levels, ultimately leading to reduced NB aggressiveness. Here, we selected (−)-epigallocatechin 3-gallate (EGCG) out of 4959 molecules screened as the molecule with the best inhibitory activity on LIN28B/let-7 miRNA interaction and showed that treatment with PLC/PLGA-PEG nanoparticles containing EGCG (EGCG-NPs) led to an increase in mature let-7 miRNAs and a consequent inhibition of NB cell growth. In addition, EGCG-NP pretreatment reduced the tumorigenic potential of NB cells in vivo. These experiments suggest that the LIN28B/let-7 miRNA axis is a good therapeutic target in NB and that EGCG, which can interfere with this interaction, deserves further preclinical evaluation. Full article

In practical applications, rapid prediction and optimization of heat transfer performance are essential for premixed methane impinging flame jets (PMIFJs). This study uses computational fluid dynamics (CFD) combined with a methane detailed chemical reaction mechanism (GRI–Mech 3.0) to study the equivalence ratio (Φ), Reynolds number (Re) of the mixture, and the normalized nozzle–to–plate distance (H/d) on the heat transfer performance of PMIFJs. Moreover, the Kriging model (KM) was used to construct a prediction model of PMIFJ heat transfer performance. A genetic algorithm (GA) was used to determine the maximum likelihood function (MLE) of the model parameters for constructing KM and identify the points with the maximum root mean square error (RMSE) as the new infilled points for surrogate–based optimization (SBO). Combining these methods to analyze the simulation results, the results show that the global heat transfer performance of PMIFJs is enhanced with the increase in Φ, the increase in Re, and the decrease in H/d. Sensitivity analysis points out that Re and Φ significantly affect enhanced heat transfer, while H/d has a relatively small effect. In addition, GA was also used to search for the optimal heat transfer performance, and the global heat transfer performance at specific conditions was significantly enhanced. This study deepens the understanding of the heat transfer mechanism of impinging flame jets and provides an efficient method framework for practical applications. Full article