High-speed rubber cup polishing can exacerbate tooth surface damage, especially when preexisting conditions such as early caries or cracks exist. This study aimed to quantify the extent of damage to sound teeth based on rotating rubber cup speed and assess the damage in relation to the tooth surface condition. Using a rubber cup, 36 sound teeth were polished at 100, 3000, and 10,000 rpm, and 24 teeth with early carious lesions and 24 cracked teeth were polished at 3000 and 10,000 rpm. Polishing was performed using a rubber cup and prophylaxis paste, applying an on–off method (3.0 N force for 3 s). Damage depth was quantified using a surface profilometer and examined using scanning electron microscopy. Polishing at 10,000 rpm caused significantly more damage to sound teeth than polishing at lower speeds (depth increase: 71.45 ± 15.12 µm at 100 rpm; 61.91 ± 17.82 µm at 3000 rpm; p < 0.001). Teeth with early carious lesions or cracks demonstrated more damage after polishing than sound teeth (p < 0.05). Therefore, the rotational speed of the rubber cup has a critical impact on the extent of enamel damage. Higher speeds can increase the damage depth in both sound and damaged tooth surfaces. Full article

To mitigate food insecurity and the low economic status of amaranth farmers in south-west Nigeria, it is imperative to evaluate the predominant commercial A. hybridus cultivars using key yield and nutrient components to identify promising lines with optimum yield and nutritional quality. The current study evaluated five cultivars of Amaranthus hybridus in south-west Nigeria farms using key morphological, biochemical, and seed-proximate component parameters. The results revealed significant differences in the cultivars’ growth and yield indices. The number of leaves ranged from 16.40 to 29.48 ($\stackrel{-}{\mathrm{x}}$ = 22.10) with plant height ($\stackrel{-}{\mathrm{x}}$ = 50.28 cm), while other leaf metrics varied at maturity. Days to 50% flowering ranged from 49 to 90 days. Seed proximate composition also varied significantly. Carbohydrate content ranged from 65.01–76.28%, protein content 6.57–12.42%, ash content 2.73–3.59%, total polyphenols 23.36–29.64 mg/100 g GAE, and total antioxidants 31.6–181.59 mg/100 g AAE. The Pearson correlation matrix and path analysis showed significant relationships among the yield components. The phenotypic variance of the yield components mainly stemmed from environmental factors, indicating their crucial role in the traits’ expression. Careful evaluation of the cultivars revealed that AM-1 and AM-3 had the best growth and yield attributes. Additionally, the two cultivars showed a significant degree of relatedness, suggesting a common ancestor. They have the potential to increase productivity, farmers’ profitability, and consumers’ nutrient gain compared to other cultivars. They are recommended for cultivation and can be further crossed in breeding programs to develop superior lines. Full article

Paving blocks are widely used in engineering construction for durable pavement surfaces characterized by their interlocking capability to enhance structural integrity. This study explores the potential use of char as a byproduct from coal pyrolysis and an alternative raw material to natural aggregates in developing paving blocks, aiming to reduce the associated environmental issues associated with the uncontrolled and excessive mining of natural resources. This study finds the paving blocks made from char to have the required engineering properties as mentioned by ASTM standard C936. Trass and trass-lime are added as supplementary cementitious materials (SCMs) to enhance the performance of char-based paving blocks. The incorporation of SCMs as a cement replacement also aims to reduce the carbon footprint arising from increased cement use. The compressive strength increased from 55.7 MPa to 65.71 MPa at 12.5% cement replacement with trass-lime. The water absorption is reduced to 4.63% from 4.95%. Beneficial effects towards freeze–thaw durability and abrasion resistance are also observed on trass-lime-incorporated paving blocks. This study signifies the remarkable potential use of coal-derived char and SCMs in developing light, high-strength, and durable paving blocks, showcasing their competitive engineering performance. These new char-based paving blocks will contribute towards a more sustainable construction environment and advance the current construction and engineering practices. Full article

The SYNERGIE study documented the effects on cardiometabolic risk (CMR) indices of a 1-year lifestyle intervention targeting physical activity (PA) and diet followed by a 2-year maintenance period in men with visceral obesity. Improvements in CMR markers and a decrease in low-attenuation muscle (LAM) area were observed after 1 year. Despite a rebound in visceral adipose tissue (VAT) during the maintenance period, insulin resistance (IR) improved. We tested the hypothesis that variations in cardiorespiratory fitness (CRF) and LAM could explain the long-term improvement in IR. A health (n = 88; mean age 49.0 ± 8.2 years) and fitness (n = 72) evaluation was performed at 0, 1, and 3 years. Participants were classified into two groups based on their CRF response over the maintenance period (worsening: CRF− vs. maintenance/improvement: CRF+). During the maintenance period, changes in the psoas and core LAM areas correlated with changes in IR (r = 0.27; p < 0.05 and r = 0.34; p < 0.005) and changes in CRF (r = −0.31; p < 0.01 and r = −0.30; p < 0.05). IR improved in the CRF+ group (p < 0.05) but remained stable in the CRF− group. Men in the CRF+ group regained half of the changes in VAT volume and LAM at the psoas and mid-thigh compared to the CRF− group (p < 0.05). These results support the importance of targeting VAT and CRF/PA for the long-term management of CMR in men with visceral obesity. Full article

The Indoor Environmental Quality (IEQ) combines thermal, visual, acoustic, and air-quality conditions in indoor environments and affects occupants’ health, well-being, and comfort. Performing continuous monitoring to assess IEQ is increasingly proving to be important, also due to the large amount of time that people spend in closed spaces. In the present study, the design, development, and metrological characterization of a low-cost multi-sensor device is presented. The device is part of a wider system, hereafter referred to as PROMET&O (PROactive Monitoring for indoor EnvironmenTal quality & cOmfort), that also includes a questionnaire for the collection of occupants’ feedback on comfort perception and a dashboard to show end users all monitored data. The PROMET&O multi-sensor monitors the quality conditions of indoor environments thanks to a set of low-cost sensors that measure air temperature, relative humidity, illuminance, sound pressure level, carbon monoxide, carbon dioxide, nitrogen dioxide, particulate matter, volatile organic compounds, and formaldehyde. The device architecture is described, and the design criteria related to measurement requirements are highlighted. Particular attention is paid to the calibration of the device to ensure the metrological traceability of the measurements. Calibration procedures, based on the comparison to reference standards and following commonly employed or ad hoc developed technical procedures, were defined and applied to the bare sensors of air temperature and relative humidity, carbon dioxide, illuminance, sound pressure level, particulate matter, and formaldehyde. The next calibration phase in the laboratory will be aimed at analyzing the mutual influences of the assembled multi-sensor hardware components and refining the calibration functions. Full article

Two summation theorems concerning the ${}_2{F}_1(1/2)$-series due to Gauss and Bailey will be examined by employing the “coefficient extraction method”. Forty infinite series concerning harmonic numbers and binomial/multinomial coefficients will be evaluated in closed form, including eight conjectured ones made by Z.-W. Sun. The presented comprehensive coverage for the harmonic series of convergence rate “$1/2$” may serve as a reference source for readers. Full article

Background: Photodynamic therapy (PDT) can be a promising alternative for patients with acne vulgaris. Our study aimed to evaluate the efficacy and safety of red light photodynamic therapy with BF-200 ALA gel in the treatment of different types of acne vulgaris. Methods: We performed a retrospective, observational study of a series of 22 cases. All patients were treated according to a mild PDT protocol. After a careful wash of the affected skin areas, BF-200 ALA gel was applied to the skin in a thin layer and incubated for 30 min, followed by illumination using narrow-spectrum red light (635 nm) at a dose of 4 J/cm². Most patients received one (36.4%), two (27.3%), or three (22.7%) PDT sessions. About a third of the patients received concomitant acne treatment with topical retinoids. Results: Patients of 25.1 ± 8.9 years suffering from papulopustular (45.5%), nodular (27.3%), and comedonal acne (27.3%) in the face were included. Irrespective of acne type or severity, 95.5% of patients had good or excellent responses to the treatment with PDT (≥60% lesion clearance). We found no association between concomitant acne medication and the favorable results achieved by PDT. Most patients reported no adverse events (72.7%), except for six patients who experienced erythema. The good efficacy results were maintained over a follow-up period of 12.5 ± 10.8 months. Conclusions: In this study, we show that PDT with BF-200 ALA gel and low light dose is an effective and long-lasting option for the treatment of different acne types. Full article

Citizen science is an effective tool that unites ordinary citizens and scientists for a common cause. In particular, this tool enables ordinary citizens to participate in research and increases the likelihood of generating new knowledge. It is seen as the democratization of science. It is mainly applied in developed countries, and citizens usually help obtain environmental data with emerging technologies. However, training citizens to obtain good-quality data is one of the most significant challenges. It is also important to involve citizens in other phases, such as data analysis, discussion, and knowledge generation. Citizen science can be a tool for integrating different groups in science to promote social inclusion, including environmental, agricultural, earth, and life sciences. Thus, citizen science can contribute to education, sustainability, and climate change mitigation. Full article

Wildland fire dispatchers play a key role in wildland fire management and response organization; however, to date, wildland fire studies have largely focused on the physical hazards and, to a lesser extent, mental health hazards of wildland firefighting operational personnel, and dispatcher studies have primarily focused on 911 and police dispatchers. Studies of other dispatchers have provided some limited insight into potential strains impacting this workforce, including work-related fatigue, burnout, and traumatic exposure. However, the specific job hazards that are faced by wildland fire dispatchers are poorly understood. In 2023, we conducted a cross-sectional survey of 510 wildland fire dispatchers with questions about their occupational health, general health, and well-being. We used validated screening instruments to measure the rates of anxiety, depression, PTSD, and suicidal thoughts and ideation. Here, we also present the results of mental health and trauma exposure questions that were asked as part of a larger survey. We found that demographic factors were significant indicators of anxiety, depression, and binge/restrictive eating. Our data indicate that rates of anxiety, depression, PTSD, and suicidal thoughts and ideation are significantly higher for both the wildland fire dispatching workforce and other emergency responder populations than those of the general United States population. Full article

Lost-wax glass casting, an esteemed yet technically demanding art form, traditionally relies on specialized, costly kiln equipment, presenting significant barriers to artists regarding equipment affordability, energy efficiency, and the technical mastery required for temperature control. Therefore, this study introduces an innovative approach by integrating a microwave kiln with standard household microwave ovens, thus facilitating the lost-wax glass casting process. This methodological adaptation allows artists to employ readily available home appliances for glass creation, significantly reducing the process’s cost and complexity. Our experimental investigations reveal that, by using a 500W household microwave oven for heating, the silicon carbide (SiC) in microwave kilns can efficiently absorb microwave energy, allowing the kilns to reach temperatures exceeding 700 °C, a critical threshold for casting glass softening. We further demonstrate that by adjusting the number of heating cycles, producing high-quality, three-dimensional(3D) glass artworks is feasible, even for large-scale projects. In addition, the microwave kiln can be used as an effective cooling tool to uniformly cool the formed casting glass. This study presents a possible alternative to conventional kiln technology and marks a paradigm shift in glassmaking, offering a more accessible and sustainable avenue for artists and practitioners. Full article

Background: In Nigeria, most children with tuberculosis (TB) present at primary health clinics where there are limited personnel skilled in collecting appropriate respiratory specimens from those who cannot produce sputum. KNCV Nigeria, in collaboration with the National Tuberculosis Control Program, implemented a modified simple, one-step (SOS), stool-based Xpert MTB/RIF method for diagnosis of TB in children who cannot expectorate sputum. We evaluated the impact of its implementation on childhood TB diagnosis. Method: A cross-sectional study was conducted across 14 selected states using secondary data of children presumed to have TB. Stool was collected from children presumed to have TB and processed using Xpert. Result: Out of 52,117 presumptive TB cases, 52% were male and 59.7% were under 5 years old. A total of 2440 (5%) cases were diagnosed with TB, and 2307 (95%) were placed on treatment. Annual TB notifications increased significantly after the introduction of the stool-based Xpert test when compared to those in the pre-implementation period. Increasing contributions from stool testing were observed throughout the implementation period, except in 2020 during the COVID-19 era. Overall, stool Xpert testing improved childhood TB notification in the studied states. Interventions aimed at awareness creation, capacity building, and active case finding improved the performance of the test. Full article

Chronic pain in the vulnerable phase of emerging adulthood is associated with severe life impairments. The current healthcare system has no suitable treatments for young people. A new multimodal inpatient and app-supported treatment for young people with chronic pain counteracts this. The study examines the effectiveness of this new treatment. Our mixed-methods design combined qualitative and quantitative evaluations. The sample comprised N = 44 patients (18–25 years) who took part in the new treatment. The quantitative data showed a reduced degree of pain severity, pain-related and emotional impairments, and an improved quality of life. The qualitative data showed that several components of the new treatment were particularly important to the young adults: individuality and taking the patient seriously, group therapy with peers, individual therapies (psychological, medical), life counselling, and sports. Results support the individual and objective success of a new inpatient pain treatment applied during emerging adulthood. Full article

Background: To achieve zero leprosy cases in Santa Cruz, Bolivia, we designed a community-based active detection and provision of single-dose rifampicin post-exposure prophylaxis (SDR-PEP) to household contacts with new leprosy patients. Methods: From July to August 2021, we assessed the current knowledge, attitude, and practices through structured interviews and focus group discussions with community representatives and health staff. This was followed by sensitization sessions, the training of health staff, and the reinforcement of referral mechanisms. Teams, including health staff and community volunteers, visited all new leprosy patients detected in 2021–2023 and household contacts. Results: Among 115 community representatives, knowledge about leprosy etiology was attributed to non-biological factors (74%); fear accounted for 77%, and access to care was perceived as weak (74%), but the outlook was improved by SDR-PEP (80%). Among the 217 health staff interviewed, the programmatic barriers identified were a lack of referral feedback (67%), limited supplies for diagnosis and prevention, and ineffective training (64%). We visited 70 new patients and 258 household contacts. The median age in household contacts was 25 years old; 49% were women, 98% were eligible for SDR-PEP, and all who were eligible accepted it. Those who were non-eligible included one tuberculosis patient and six newly detected leprosy patients (23‰). Conclusions: A community-based intervention was successful in Santa Cruz, Bolivia. Misbeliefs and a lack of knowledge were identified as barriers. Programmatic components should be reinforced for SDR-PEP extension. Full article

This article draws on case studies or ‘microhistories’ from the author’s own research to explore the ethical responsibility of family historians to represent the experiences of those whose lives have been ‘hidden from history’, and in particular the lives of one’s female ancestors, as a way of correcting the omissions and erasures of official histories. It also discusses the ethical dilemmas posed by the discovery that one’s ancestors were involved in activities that are now regarded as morally suspect, such as profiting from the ownership of slaves. Finally, the article debates ethical arguments about respecting the rights of the dead to privacy. Full article

The diversity of alcohol beverage microorganisms is of great significance for improving the brewing process and the quality of alcohol beverage products. During the process of making alcoholic beverages, a group of microorganisms, represented by yeast and lactic acid bacteria, conducts fermentation. These microorganisms have complex synergistic or competitive relationships, and the participation of different microorganisms has a major impact on the fermentation process and the flavor and aroma of the product. Strain selection is one of the key steps. Utilizing scientific breeding technology, the relationship between strains can be managed, the composition of the alcoholic beverage microbial community can be improved, and the quality and flavor of the alcoholic beverage products can be increased. Currently, research on the microbial diversity of alcohol beverages has received extensive attention. However, the selection technology for dominant bacteria in alcohol beverages has not yet been systematically summarized. To breed better-quality alcohol beverage strains and improve the quality and characteristics of wine, this paper introduces the microbial diversity characteristics of the world’s three major brewing alcohols: beer, wine, and yellow wine, as well as the breeding technologies of related strains. The application of culture selection technology in the study of microbial diversity of brewed wine was reviewed and analyzed. The strain selection technology and alcohol beverage process should be combined to explore the potential application of a diverse array of alcohol beverage strains, thereby boosting the quality and flavor of the alcohol beverage and driving the sustainable development of the alcoholic beverage industry. Full article

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive neoplasia, characterized by early metastasis, low diagnostic rates at early stages, resistance to drugs, and poor prognosis. There is an urgent need to better characterize this disease in order to identify efficient diagnostic/prognostic biomarkers. Since microRNAs (miRNAs) contribute to oncogenesis and metastasis formation in PDAC, they are considered potential candidates for fulfilling this task. In this work, the levels of two miRNA subsets (involved in chemoresistance or with oncogenic/tumor suppressing functions) were investigated in a panel of PDAC cell lines and liquid biopsies of a small cohort of patients. We used RT-qPCR and droplet digital PCR (ddPCR) to measure the amounts of cellular- and vesicle-associated, and circulating miRNAs. We found that both PDAC cell lines, also after gemcitabine treatment, and patients showed low amounts of cellular-and vesicle-associated miR-155-5p, compared to controls. Interestingly, we did not find any differences when we analyzed circulating miR-155-5p. Furthermore, vesicle-related miR-27a-3p increased in cancer patients compared to the controls, while circulating let-7a-5p, miR-221-3p, miR-23b-3p and miR-193a-3p presented as dysregulated in patients compared to healthy individuals. Our results highlight the potential clinical significance of these analyzed miRNAs as non-invasive diagnostic molecular tools to characterize PDAC. Full article

Carbon xerogel spheres co-doped with nitrogen and eco-graphene were synthesized using a typical solvothermal method. The results indicate that the incorporation of eco-graphene enhances the electrochemical properties, such as the current density (J_K) and the selectivity for the four transferred electrons (n). Additionally, nitrogen doping has a significant effect on the degradation efficiency, varying with the size of the carbon xerogel spheres, which could be attributed to the type of nitrogenous group doped in the carbon material. The degradation efficiency improved in the nanometric spheres (48.3% to 61.6%) but decreased in the micrometric-scale spheres (58.6% to 53.4%). This effect was attributed to the N-functional groups present in each sample, with N-CNS-5 exhibiting a higher percentage of graphitic nitrogen (35.7%) compared to N-CMS-5 (15.3%). These findings highlight the critical role of sphere size in determining the type of N-functional groups present in the sample. leading to enhanced degradation of pollutants as a result of the electro-Fenton process. Full article

Nanostructured lipid carriers (NLCs) have the potential to increase the bioavailability and reduce the side effects of docetaxel (DTX). However, only a small fraction of nanoparticles given intravenously can reach a solid tumor. In situ-forming gels combined with nanoparticles facilitate local administration and promote drug retention at the tumor site. Injectable hydrogels based on poloxamer 407 are excellent candidates for this hybrid nanoparticle–hydrogel system because of their thermoresponsive behavior and biocompatibility. Therefore, this work aimed to develop injectable poloxamer hydrogels containing NLCs for intratumoral delivery of DTX. To ensure sterility, the obtained hydrogels were autoclaved (121 °C for 15 min) after preparation. Then, the incorporation of NLCs into the poloxamer hydrogels and the impact of steam sterilization on the nanocomposite hydrogels were evaluated concerning sol–gel transition, injectability, and physicochemical stability. All formulations were extruded through the tested syringe–needle systems with acceptable force (2.2–13.4 N) and work (49.5–317.7 N·mm) of injection. Following steam sterilization, injection became easier in most cases, and the physicochemical properties of all hydrogels remained practically unchanged according to the spectroscopical and thermal analysis. The rheological evaluation revealed that the nanocomposite hydrogels were liquid at 25 °C and underwent rapid gelation at 37 °C. However, their sterilized counterparts gelled at 1–2 °C above body temperature, suggesting that the autoclaving conditions employed had rendered these nanocomposite hydrogels unsuitable for local drug delivery. Full article

In this study, we investigated the structural properties and digestibility of wheat starch treated with octenyl succinic anhydride (OSA). For the experiment, the samples were reacted with 2, 4, 6, 8, and 10% OSA (pH 8.5–9.0) for 2 h. A light micrograph showed that there was no difference in the morphology and Maltese cross between native and OSA-treated starch. The X-ray diffraction (XRD) patterns of the native and OSA-treated starches showed typical A-type diffraction. In addition, the Fourier transform infrared (FT-IR) spectrum showed a distinct carbonyl peak at approximately 1730 cm⁻¹, indicating the stretching vibration of the C=O bond of the ester group. The degree of substitution (DS) and content of resistant starch (RS) increased with increasing concentrations of treated OSA because of the increase in ester bonds. In particular, RS was thermostable compared to the RS content in uncooked and cooked starch. Blood glucose levels and response in vivo decreased as the OSA concentration increased. Treatment of wheat starch with 8% OSA concentration produced 35.6% heat-stable resistant starch. These results suggest that starch modified with OSA can be used to produce functional foods for diabetes. Full article

The cause(s) of missing inflectional morphology in obligatory contexts by adult speakers of second language (L2) English is subject to ongoing discussion. Whatever the specific theory, however, the apparent asymmetrical production of the morpheme ‘-s’ in the marking of number on plural nouns versus that on third person singular agreement has to be accounted for. This study adopts the theoretical approach put forward by the Prosodic Transfer Hypothesis, whereby the prosodic representation of inflectional morphology in the first language (L1) can, to some extent, account for differences in the suppliance of inflectional morphology in L2 English within and across L1s. It is in this context that the production of third person singular agreement, and, for contrastive purposes, number on plural nouns, by L1 Bengali speakers of L2 English, is are considered in relation to available prosodic representation in the L1, as well as against phonological processes attested in L1 acquisition. More specifically, covert contrasts. An inspection of spectrograms from instances of the omission of inflection by L1 Bengali speakers of L2 English at Beginner to Intermediate proficiency levels does not, however, indicate that learners are covertly supplying agreement on the third person singular (or plural number on nouns). This finding does not necessarily rule out the occurrence of covert contrasts in L2 production of inflectional morphology; alternative techniques may detect a systematic difference between bare verbs and non-audible (to the listener) inflection. Full article