The following prospective study has the aim of evaluating the efficiency of the F22 MAD (mandibular advancement device), a new oral device for the treatment of OSAS (Obstructive Sleep Apnea Syndrome) and snoring. Methods: AHI (apnea-hypopnea index), ODI (Oxygen Desaturation Index), snoring percentage, time spent in the supine position, and Epworth Sleepiness Scale score were evaluated in 19 patients with snoring, mild to moderate OSAS, or severe OSAS who declined CPAP (Continuous Positive Air Pressure) treatment, before and after the application of the F22 MAD. Results: The median value of AHI varied from 15.6 ± 10.7 to 5.7 ± 5.7; the median value of ODI varied from 13.4 ± 8.8 to 6.2 ± 5.2; the median value of the percentage of snoring varied from 30.7 ± 7 to 7.5 ± 10.8, except for the patient who has severe OSAS who increased their value. The value obtained by the self-completion of the ESS questionnaire (Epworth Sleepiness Scale) underwent a statistically significant variation, while clinically significant for 13\19 patients who obtained a reduction of the value >/= of 2 points. Conclusions: It is possible to conclude that the F22 MAD is effective in the treatment of patients with mild and moderate OSAS or simple snoring, reducing the polysomnographic outcomes with statistically and clinically significant results in terms of reduction of AHI, ODI and percentage of snoring. Full article

ABO incompatibility is not considered a contraindication for hematopoietic stem cell transplantation (HSCT). Approximately 30% of transplants from related donors and up to 50% of transplants from unrelated donors are ABO incompatible. Immuno-hematologic investigations allow to estimate donor/recipient ABO mismatch and anti-A/B isohemagglutinin (IHA) titration in the pre-HSCT phase. Immediate hemolysis or delayed complications (passenger lymphocyte syndrome and pure red cell aplasia) can occur post HSCT. Some preventive measures take into consideration either decision-making algorithms based on the recipient’s IHA titration or clinical protocols for the removal/reduction of IHAs through plasma exchange or immunoadsorption procedures. Product manipulation through red blood cell (RBC) and/or plasma depletion can also be taken into account. Currently, the best approach in the management of ABO-incompatible transplant is not defined in expert consensus documents or with solid evidence. In addition, the methods for IHA titration are not standardized. A transfusion strategy must consider both the donor’s and recipient’s blood group systems until the RBC engraftment catches on and ABO conversion (forward and reverse typing) is confirmed on two consecutive and independent samples. Therefore, ABO incompatibility in HSCT represents a demanding immuno-hematologic challenge and requires all necessary preventive measures, including the appropriate selection of ABO blood components for transfusion. Full article

The conditioned medium (CM) obtained from mesenchymal stromal cell (MSC) culture has excellent cell growth-promoting activity and is used for cosmetics and healthcare products. Unlike pharmaceuticals, strict efficacy verification is not legally required for these products. However, their efficacy must be substantiated as commercial products. We attempted to simplify CM production and to standardize the evaluation of the growth-promoting activity of CM. CM was obtained through the culturing of two lines of commercially available human adipose tissue-derived MSCs using MEMα with or without 10% fetal bovine serum (FBS) for 24 h. Non-CM control media were produced by the same protocol without MSCs. Growth-promoting activities of the CM were estimated by [³H]-thymidine pulse. CM were subjected to molecular weight fractionation with ultrafiltration using 10 k-, 30 k-, 50 k-, and 100 k-membranes. The FBS-free CMs showed 1.34- to 1.85-fold increases and FBS-containing CMs showed 1.45- to 1.67-fold increases in proliferation-promoting activity compared with non-CM controls, regardless of the source of the cell. The thymidine incorporation levels were approximately three times higher in FBS-containing CMs. Aged cells also showed 1.67- to 2.48-fold increases in the activity due to FBS-containing CM, but not to FBS-free CM. The CM activities were sustained even after 1 year at 4 °C. Molecular weight fractionation showed that the activity was recovered in the fraction above 100 k. Clear and stable cell-growth-promoting activity was confirmed with CMs of commercially available adipose tissue MSCs. The activity was detected in the fraction over 100 k. We propose here the importance of standardizing the production and evaluation of CMs to indicate their specific action. Full article

Mucosal healing (MH) is the main target in ulcerative colitis (UC) treatment. Even if MH lowers the risk of disease reactivation, some patients still relapse. Histologic activity (HA) beyond MH could explain these cases. This study aims to assess how many patients with MH have HA and which lesions are associated with relapse. We retrospectively enrolled UC patients showing MH, expressed as a Mayo Endoscopic Subscore (MES) of 0 and 1 upon colonoscopy. We reviewed the histological reports of biopsies evaluating the presence of typical lesions of UC and assessed the number of clinical relapses after 12 months. Among 100 enrolled patients, 2 showed no histological lesions. According to univariate analysis, patients with a higher number of histological lesions at the baseline had a higher risk of relapse (OR 1.25, p = 0.012), as well as patients with basal plasmacytosis (OR 4.33, p = 0.005), lamina propria eosinophils (OR 2.99, p = 0.047), and surface irregularity (OR 4.70, p = 0.010). However, in the multivariate analysis, only basal plasmacytosis (OR 2.98, p = 0.050) and surface irregularity (OR 4.50, p = 0.024) were confirmed as risk factors for disease reactivation. HA persists in a significant percentage of patients with MH. Despite the presence of MH, patients with basal plasmacytosis and surface irregularity have a higher risk of relapse. Full article

Sodium hyaluronate (HA) is a natural polysaccharide. This biopolymer occurs in many tissues of living organisms. The regenerating, nourishing, and moisturizing properties as well as the rheological properties of HA enable its application in the pharmaceutical industry as a carrier of medicinal substances. The aim of this work was to assess the release of naproxen sodium (Nap) in the presence of lidocaine hydrochloride (Lid) from the biopolymer-based hydrogels and to determine the respective kinetic parameters of this process. The possible interaction between the HA polysaccharide carrier and the selected drugs was also investigated. Three hydrogels containing Nap and Lid with different concentrations of the biopolymer were prepared. The release of Nap was studied by employing USP apparatus 5. The infrared study and differential scanning calorimetry analysis of physical mixtures and dried formulations were performed. The highest amount of Nap was released from the formulation with the lowest concentration of the biopolymer. The most representative kinetic model that described the dissolution of Nap was obtained through the Korsmeyer–Peppas equation. The release rate constants were in the range of 1.0 ± 0.1 × 10⁻² min⁻ⁿ–1.7 ± 0.1 × 10⁻² min⁻ⁿ. Lid did not influence the dissolution of Nap from the formulations tested; however, in the desiccated samples of assessed formulations, the interaction between the polysaccharide and both drugs was observed. Full article

Training an effective deep learning model to learn ocean processes involves careful choices of various hyperparameters. We leverage DeepHyper’s advanced search algorithms for multiobjective optimization, streamlining the development of neural networks tailored for ocean modeling. The focus is on optimizing Fourier neural operators (FNOs), a data-driven model capable of simulating complex ocean behaviors. Selecting the correct model and tuning the hyperparameters are challenging tasks, requiring much effort to ensure model accuracy. DeepHyper allows efficient exploration of hyperparameters associated with data preprocessing, FNO architecture-related hyperparameters, and various model training strategies. We aim to obtain an optimal set of hyperparameters leading to the most performant model. Moreover, on top of the commonly used mean squared error for model training, we propose adopting the negative anomaly correlation coefficient as the additional loss term to improve model performance and investigate the potential trade-off between the two terms. The numerical experiments show that the optimal set of hyperparameters enhanced model performance in single timestepping forecasting and greatly exceeded the baseline configuration in the autoregressive rollout for long-horizon forecasting up to 30 days. Utilizing DeepHyper, we demonstrate an approach to enhance the use of FNO in ocean dynamics forecasting, offering a scalable solution with improved precision. Full article

Urban regeneration is a sound, sustainable urban development strategy globally. In China, promoting urban regeneration has become the national sustainable urban strategy. Under the resource constraint, it is necessary to understand what benefits different types of urban regeneration projects can contribute to urban development. Much research has contributed to evaluating the benefits of urban regeneration on the project scale. The systematic investigation of their effects on surrounding economic vitality, especially the comparison between different types of projects, is relatively downplayed. This paper aims to evaluate and compare the effects of urban regeneration projects on surrounding economic vitality by calculating the change in housing prices. Chongqing is selected as the case city. Based on the housing transaction data from 2015 to 2021, a staggered difference-in-difference method is employed to capture the results. The finding shows that the overall effects are significantly negative, especially within a 400–800 m radius. Higher investment or better project location relates to stronger negative effects. Moreover, the differences in effects among the three types of urban regeneration projects are clearly revealed from diverse perspectives. It provides a valuable reference for policymakers and urban planners to make urban regeneration planning better by considering comprehensive benefits. Full article

Compared to steam reforming techniques, partial oxidation of methane (POM) is a promising technology to improve the efficiency of synthesizing syngas, which is a mixture of CO and H₂. In this study, partial oxidation of methane (POM) was used to create syngas, a combination of CO and H₂, using the SAPO-5-supported Ni catalysts. Using the wetness impregnation process, laboratory-synthesized Ni promoted with Sr, Ce, and Cu was used to modify the SAPO-5 support. The characterization results demonstrated that Ni is appropriate for the POM due to its crystalline structure, improved metal support contact, and increased thermal stability with Sr, Ce, and Cu promoters. During POM at 600 °C, the synthesized 5Ni+1Sr/SAPO-5 catalyst sustained stability for 240 min on stream. While keeping the reactants stoichiometric ratio of (CH₄:O₂ = 2:1), the addition of Sr promoter and active metal Ni to the SAPO-5 increased the CH₄ conversion from 41.13% to 49.11% and improved the H₂/CO ratio of 3.33. SAPO-5-supported 5Ni+1Sr catalysts have great potential for industrial catalysis owing to their unique combination of several oxides. This composition not only boosts the catalyst’s activity but also promotes favorable physiochemical properties, resulting in improved production of syngas. Syngas is a valuable intermediate in various industrial processes. Full article

Several medicinal herbal plants are extensively used as sources of bioactive compounds with beneficial effects on human health. This study assessed the procyanidin and polyphenol profiles together with the antioxidant potential of seven herbal medical matrices. To achieve this aim, procyanidin extraction from grape pomace was optimized and validated by monitoring monomeric-trimeric procyanidins. The proposed quantification method was applied to the seven medical herbs, and it proved to be a very efficient protocol for procyanidin-rich extracts analysis. In addition, the Paullinia cupana Kunth. seed was identified as a very rich source of procyanidins (about 5 mg/g dry matrix of each dimeric and about 3 mg/g dry matrix trimeric) with high antioxidant properties. The polyphenolic profile was assessed by HPLC-HESI-MS/MS analysis. The in vitro antioxidant activity was evaluated by DPPH assay to explore the antioxidant properties of the extracts, which were substantially higher in Peumus boldus Molina leaves extracts (935.23 ± 169 μmol of Trolox equivalent/g of dry weight) concerning the other matrices. Moreover, a high Pearson coefficient value was observed between the total flavonoid content (TFC) and DPPH in comparison with the total polyphenol content (TPC) and DPPH, indicating flavonoids as the principal bioactive with antioxidant activity in the extracts. Full article

Noncoding RNAs (ncRNAs) play key roles in the regulation of important pathways, including cellular growth, stress management, signaling, and biofilm formation. Sulfate-reducing bacteria (SRB) contribute to huge economic losses causing microbial-induced corrosion through biofilms on metal surfaces. To effectively combat the challenges posed by SRB, it is essential to understand their molecular mechanisms of biofilm formation. This study aimed to identify ncRNAs in the genome of a model SRB, Oleidesulfovibrio alaskensis G20 (OA G20). Three in silico approaches revealed genome-wide distribution of 37 ncRNAs excluding tRNAs in the OA G20. These ncRNAs belonged to 18 different Rfam families. This study identified riboswitches, sRNAs, RNP, and SRP. The analysis revealed that these ncRNAs could play key roles in the regulation of several pathways of biosynthesis and transport involved in biofilm formation by OA G20. Three sRNAs, Pseudomonas P10, Hammerhead type II, and sX4, which were found in OA G20, are rare and their roles have not been determined in SRB. These results suggest that applying various computational methods could enrich the results and lead to the discovery of additional novel ncRNAs, which could lead to understanding the “rules of life of OA G20” during biofilm formation. Full article

Human footsteps are a sustainable energy source that is derived from kinetic energy. As a result, in this study, piezoelectric sensors placed beneath floor tiles were excited by human footsteps to provide practical electrical energy. A simple rectifying circuit with a filter was used to capture electrical power. The floor tile is 455 mm in length and 405 mm in width. Two light-emitted diodes were lit up as the actual load by utilising electrical energy obtained from the kinetic energy generated by human footsteps. The greatest attainable power that could be extracted from the suggested floor tile was 249.6 milliwatts, with an approximate cost of $10.2. Full article

Uneven settlement of transmission tower foundations can result in catastrophic events, such as tower collapse and line failures, disrupting power transmission operations. To address the challenging repairs caused by uneven foundation settlement of transmission towers, we propose an adjustable foundation bolt (AFB). This paper provides a detailed theoretical analysis of the AFB’s stability and load-bearing capacity, including critical buckling force formulas and maximum normal stress expressions. Finite element simulations confirm the precision of our theoretical formulations. Additionally, we introduce a method using baffles to enhance its load-bearing capacity, analyzing the impact of different numbers of baffles through numerical simulations. The experimental results validate the effectiveness of baffles in enhancing structural load-bearing capacity. The device brings convenience and efficiency to the maintenance of transmission towers. Full article

As antibiotic resistance increasingly undermines traditional infection management strategies, there is a critical demand for innovative wound care solutions that address these emerging challenges. This study introduces a novel antibacterial wound dressing based on Cross-Linked Pullulan (Pul) and Polyhexamethylene Biguanide (PHMB) for enhanced wound management and infection control. The dressing’s adsorption rate reached 200% of its original weight within 30 min, exceeded 300% after 5 h, and exhibited significant non-Newtonian fluid properties. The dressings were able to release the loaded medication completely within 20 min; additionally, the dressing demonstrated significant antibacterial activity against a broad spectrum of bacteria. Significantly, the therapeutic effects of the Pul-PHMB/GP dressing were evaluated in a mouse model. Compared to untreated wounds, wounds treated with Pul-PHMB/GP exhibited a significant gelation process within 5 min post-treatment and showed a significant increase in wound healing rate within 12 days. This powder preparation overcomes the limitations associated with liquid and gel dressings, notably in storage and precise application, preventing the premature expansion or dissolution often caused by PHMB in high-humidity environments. The powder form can transform into a gel upon contact with wound exudate, ensuring accurate coverage of irregular wounds, such as those from burns or pressure sores, and offers excellent chemical and physical stability in a dry state, which facilitates storage and transport. This makes the dressing particularly suitable for emergency medical care and precision therapy, significantly improving the efficiency and adaptability of wound treatment and providing robust support for clinical treatments and emergency responses. Full article

Climate change-induced weather events, such as extreme temperatures, prolonged drought spells, or flooding, pose an enormous risk to crop productivity. Studies on the implications of multiple stresses may vary from those on a single stress. Usually, these stresses coincide, amplifying the extent of collateral damage and contributing to significant financial losses. The breadth of investigations focusing on the response of horticultural crops to a single abiotic stress is immense. However, the tolerance mechanisms of horticultural crops to multiple abiotic stresses remain poorly understood. In this review, we described the most prevalent types of abiotic stresses that occur simultaneously and discussed them in in-depth detail regarding the physiological and molecular responses of horticultural crops. In particular, we discussed the transcriptional, posttranscriptional, and metabolic responses of horticultural crops to multiple abiotic stresses. Strategies to breed multi-stress-resilient lines have been presented. Our manuscript presents an interesting amount of proposed knowledge that could be valuable in generating resilient genotypes for multiple stressors. Full article

Existing direct and inverse kinematic models of planar parallel robots assume that the robot’s active joints are all at the bases. However, this approach becomes excessively complex when modeling a planar parallel robot in which the active joints are within one single kinematic chain. To address this problem, our article unveils an alternative for a 3RRR symmetric planar robot modeling technique for the derivation of the robot workspace and the analysis of its direct and inverse kinematics. The workspace was defined using a system of inequalities, and the direct and inverse kinematics models were generated using vectorial analysis and an optimized geometrical approach, respectively. The resulting models are systematically presented and validated. Two final model renditions are delivered supplying a thorough equation analysis and an applicability discussion based on the importance of the robot’s mobile platform orientation. The advantages of this model are discussed in comparison to the traditional modeling approach: whereas conventional techniques require the solution of complex eighth-degree polynomials for the analysis of the active joint configuration of these robots, these models provide an efficient back-of-the-envelope analysis approach that requires the solution of a simple second-degree polynomial. Full article

This article presents the results of an experimental verification of three-phase Dy transformer dynamics under no-load conditions. This study is motivated by previous ferroresonance analyses where the occurrence of inrush currents has been observed. The measurements covered all available electrical quantities in a transient state (12 measured and 3 additionally computed waveforms) during the device’s start-up under no-load conditions, as well as in a long-term steady state. A detailed analytical analysis is carried out for the obtained comprehensive set of measurement results. As a result of the conducted research, the mathematical model of the pre-magnetized three-phase Dy transformer is modified. Particular attention is paid to the issue of residual magnetism of the transformer core and its consideration in further research. The original strategy for energizing a three-column three-phase Dy transformer with a suitable pre-magnetization of its columns and original control switching system with a given/set value of the initial phase in the supply voltage is put to the test. The evolution of the induced inrush phenomenon up to the quasi-steady state under given (forced) conditions is documented (currents, voltages and the dynamics of changes taking place in the core (hysteresis loops)). This article represents a continuation of ongoing work on the study of transient states (dynamics of transformer inrush currents). At present, the Dy three-phase transformer is analyzed because of the requirements of industrial operators. Full article

European hazelnut (Corylus avellana L.) cultivation has grown worldwide in recent years, even though the world’s production is still fulfilled by a few dozen cultivars well adapted to the local environments of their selection. After Turkey, Italy is the second largest producer of hazelnuts, and the province of Viterbo, in central Italy, is recognized as one of the most suitable districts for hazelnut cultivation. The production in this area relies almost entirely on local cultivar ‘Tonda Gentile Romana’, whereas cultivar ‘Nocchione’ is used as the main pollinizer. More recently, cultivar ‘Tonda di Giffoni’ has been introduced in new local plantations. Cultivation of many cultivars in different areas is of fundamental importance to test their adaptability to different environmental conditions, a need currently accentuated by ongoing climate change. With this aim, a European hazelnut collection field was established in 2000 in Caprarola municipality (Viterbo province), where plants of twelve hazelnut cultivars were observed over four growing seasons for their phenological, agronomic and nut traits. The cultivars studied, namely ‘Barcelona’, ‘Camponica’, ‘Ennis’, ‘Merveille de Bollwiller’, ‘Negret’, ‘Nocchione’, ‘Riccia di Talanico’, ‘San Giovanni’, ‘Tombul’, ‘Tonda di Giffoni’, ‘Tonda Gentile’ and ‘Tonda Gentile Romana’, showed a high diversity in their phenological behaviour, yield efficiency and nut and kernel traits. Cultivars ‘Negret’, ‘Tombul’ and ‘Tonda Gentile’, with poor yields over the years of research, do not seem suitable to be cultivated as main cultivars in the studied environment, contrary to ‘Camponica’ and ‘San Giovanni’, which produced abundantly, reaching a total of almost 30 and 25 kg plant^—1 of in–shell hazelnuts, respectively. Cultivars ‘Tonda Gentile Romana’ and ‘Nocchione’ confirmed their yield consistency, whereas ‘Ennis’, ‘Barcelona’ and ‘Tombul’ seem suitable to be introduced as pollinizers thanks to their male blooming overlapping with the female blooming of the main cultivar ‘Tonda Gentile Romana’. Cultivar ‘Tonda di Giffoni’ did not perform well in the studied environment, despite being recognized as one of the highest-yield cultivars. Full article

Chitosan, a versatile biopolymer derived from chitin, has garnered significant attention in various biomedical applications due to its unique properties, such as biocompatibility, biodegradability, and mucoadhesiveness. This review provides an overview of the diverse applications of chitosan and its derivatives in the antibacterial, anticancer, wound healing, and tissue engineering fields. In antibacterial applications, chitosan exhibits potent antimicrobial properties by disrupting microbial membranes and DNA, making it a promising natural preservative and agent against bacterial infections. Its role in cancer therapy involves the development of chitosan-based nanocarriers for targeted drug delivery, enhancing therapeutic efficacy while minimising side effects. Chitosan also plays a crucial role in wound healing by promoting cell proliferation, angiogenesis, and regulating inflammatory responses. Additionally, chitosan serves as a multifunctional scaffold in tissue engineering, facilitating the regeneration of diverse tissues such as cartilage, bone, and neural tissue by promoting cell adhesion and proliferation. The extensive range of applications for chitosan in pharmaceutical and biomedical sciences is not only highlighted by the comprehensive scope of this review, but it also establishes it as a fundamental component for forthcoming research in biomedicine. Full article

Soil–Vegetation–Atmosphere Transfer (SVAT) models are a promising avenue towards gaining a better insight into land surface interactions and Earth’s system dynamics. One such model developed for the academic and research community is the SimSphere SVAT model, a popular software toolkit employed for simulating interactions among the layers of vegetation, soil, and atmosphere on the land surface. The aim of the present review is two-fold: (1) to deliver a critical assessment of the model’s usage by the scientific and wider community over the last 15 years, and (2) to provide information on current software developments implemented in the model. From the review conducted herein, it is clearly evident that from the models’ inception to current day, SimSphere has received notable interest worldwide, and the dissemination of the model has continuously grown over the years. SimSphere has been used so far in several applications to study land surface interactions. The validation of the model performed worldwide has shown that it is able to produce realistic estimates of land surface parameters that have been validated, whereas detailed sensitivity analysis experiments conducted with the model have further confirmed its structure and architectural coherence. Furthermore, the recent inclusion of novel functionalities in the model, as outlined in the present review, has clearly resulted in improving its capabilities and in opening up new opportunities for its use by the wider community. SimSphere developments are also ongoing in different aspects, and its use as a toolkit towards advancing our understanding of land surface interactions from both educational and research points of view is anticipated to grow in the coming years. Full article

Overcoming the blood–brain barrier (BBB) remains a significant hurdle in effective drug delivery to the brain. While the BBB serves as a crucial protective barrier, it poses challenges in delivering therapeutic agents to their intended targets within the brain parenchyma. To enhance drug delivery for the treatment of neurological diseases, several delivery technologies to circumvent the BBB have been developed in the last few years. Among them, nanoparticles (NPs) are one of the most versatile and promising tools. Here, we summarize the characteristics of NPs that facilitate BBB penetration, including their size, shape, chemical composition, surface charge, and importantly, their conjugation with various biological or synthetic molecules such as glucose, transferrin, insulin, polyethylene glycol, peptides, and aptamers. Additionally, we discuss the coating of NPs with surfactants. A comprehensive overview of the common in vitro and in vivo models of the BBB for NP penetration studies is also provided. The discussion extends to discussing BBB impairment under pathological conditions and leveraging BBB alterations under pathological conditions to enhance drug delivery. Emphasizing the need for future studies to uncover the inherent therapeutic properties of NPs, the review advocates for their role beyond delivery systems and calls for efforts translating NPs to the clinic as therapeutics. Overall, NPs stand out as a highly promising therapeutic strategy for precise BBB targeting and drug delivery in neurological disorders. Full article

This study investigates codon usage bias within the chloroplast genomes of 18 Taraxacum species, focusing on the base composition and various metrics including GC content, Relative Synonymous Codon Usage (RSCU), Effective Number of Codons (ENc), and GC3s. Our analysis revealed a pronounced preference for A/T-ending codons across Taraxacum species, with GC content across the first, second, and third positions of the codons (GC1, GC2, GC3) and the average GC content consistently below 50%. A detailed examination using the RSCU metric identified 29 commonly preferred A/T-ending codons, indicating a strong codon usage bias towards these endings. Specifically, the codon for leucine (UUA) emerged as highly preferred, while the codon for serine (AGC) was least favored. Through the ENc–GC3s plot analysis, we explored the forces shaping this bias, finding evidence that both mutation pressure and natural selection significantly influence codon preference, with most coding sequences showing weak bias. The PR2 plot analysis further confirmed the role of these factors by demonstrating a higher frequency of T over A and C over G at the third codon position, pointing towards a mutation bias complemented by natural selection. Collectively, our findings highlight a consistent pattern of codon usage bias in the chloroplast genomes of Taraxacum species, influenced by a combination of mutation pressure, natural selection, and possibly other unidentified factors. Full article

This research investigates the potential of utilizing recycled concrete aggregate (RCA) and recycled sand (RS), derived from crushed concrete cubes, as sustainable alternatives in construction materials. The study comprehensively evaluates the properties of RCA and RS, focusing on workability, impact resistance, abrasion resistance, and compressive strength to determine their viability as substitute construction materials. A notable finding is RS’s enhanced fire and heat resistance when used as a fine aggregate in mortar blends, mixed with cement and Sinicon PP in a 3:1 ratio. The experimental analysis included thorough assessments of uniformity, durability, and curing time, alongside Scanning Electron Microscopy (SEM) for structural examination. Results show that RCA has an Aggregate Impact Value (AIV) of 5.76% and a Los Angeles Abrasion Value (LAA) of 21.78%, demonstrating excellent strength of the recycled aggregates. The mortar mix was also prepared using recycled sand, cement, and Sinicon PP, and its stability was confirmed through soundness tests, which resulted in a 0.53 mm expansion and a satisfactory consistency level of 44%. Ultrasonic pulse velocity (UPV) tests also indicated high-quality concrete formation using RCA and RS. SEM imaging corroborated this by revealing a bond between the cement paste and the aggregates. Incorporating RS and RCA in concrete mixtures impressively yielded a compressive strength of 26.22 N/mm² in M20-grade concrete. The study concludes that using RCA and RS waste materials in the construction sector underlines that sustainable practices can be integrated without compromising material quality. This approach aligns with sustainable development goals and fosters a more environmentally friendly construction industry. Full article